Man

Guido Carlos Mora Longa

Académico/Investigador

Universidad SEK

Santiago, Chile

Líneas de Investigación


Educación

  •  Molecular Biology, UNIVERSITY OF WISCONSIN-MADISON. Estados Unidos, 1971
  •  Licenciado en Bioquímica y Bioquímico, UNIVERSIDAD DE CHILE. Chile, 1965

Experiencia Profesional

  •   Director Carrera Medicina Full Time

    Universidad Andres Bello

    Santiago, Chile

    2014 - 2019

Premios y Distinciones

  •   PREMIO

    ORGANIZACION PANAMERICA DE LA SALUD

    Chile, 1986

    Mejor trabajo científico presentado en el X Congreso de la Asociación Chilena de Microbiología,


 

Article (36)

Inactivation of Glutamine Synthetase-Coding Gene glnA Increases Susceptibility to Quinolones Through Increasing Outer Membrane Protein F in Salmonella enterica Serovar Typhi

Millanao A.R.; Mora A.Y.; Saavedra, C. P.; Villagra N.A.; Mora, G. C.; Hidalgo, A. A.

Article ISI SCOPUS
FRONTIERS IN MICROBIOLOGY  (2020)

Cysteine auxotrophy drives reduced susceptibility to quinolones and paraquat by inducing the expression of efflux-pump systems and detoxifying enzymes in S. Typhimurium

Villagra NA, Valenzuela LM, Mora AY, Millanao AR, Saavedra CP, Mora GC, Hidalgo AA.

Article ISI SCOPUS
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS  (2019)

Xylose Improves Antibiotic Activity of Chloramphenicol and Tetracycline against K. pneumoniae and A. baumannii in a Murine Model of Skin Infection

Hidalgo, Alejandro A.; Arias, Angel J.; Fuentes, Juan A; Garcia, Patricia; Mora, Guido C.; Villagra, Nicolas A.

Article ISI SCOPUS
CANADIAN JOURNAL OF INFECTIOUS DISEASES & MEDICAL MICROBIOLOGY  (2018)

Expression of IroN, the salmochelin siderophore receptor, requires mRNA activation by RyhB small RNA homologues

Balbontín R.; Villagra, N; Pardos de la Gándara M.; Mora, G; Figueroa-Bossi N.; Bossi L.

Article ISI SCOPUS
Molecular Microbiology  (2016)

Lose to win: marT pseudogenization in Salmonella enterica serovar Typhi contributed to the surV-dependent survival to H2O2, and inside human macrophage-like cells

Ortega, Allison P.; Villagra, Nicolás A.; Urrutia, Ítalo M.; Valenzuela, Luis M.; Talamilla-Espinoza, A.; Hidalgo, Alejandro A.; Rodas, Paula I.; Gil, Fernando; Calderón, Iván L.; Paredes-Sabja, Daniel; Mora, Guido C.; Fuentes, Juan A.

Article ISI SCOPUS
INFECTION GENETICS AND EVOLUTION  (2016)

SPI-9 of Salmonella enterica serovar Typhi is constituted by an operon positively regulated by RpoS and contributes to adherence to epithelial cells in culture

Velásquez, Juan Carlos; Hidalgo, Alejandro A.; Villagra, Nicolás A.; Santiviago, Carlos A.; Mora, Guido C.; Fuentes, Juan A.

Article ISI SCOPUS
MICROBIOLOGY-SGM  (2016)

Theoretical and experimental characterization of a novel pyridine benzimidazole: Suitability for fluorescence staining in cells and antimicrobial properties

Carreno, A.; Gacitua, M; Fuentes, J. A.; Páez-Hernández D.; Araneda, C; Chavez, I; Soto-Arriaza, M; ManrÍquez J.M.; Polanco, R.; Mora, G. C.; Otero, C.; Swords W.B.; Arratia-Perez, R

Article ISI SCOPUS
New Journal of Chemistry  (2016)

Pseudogenization of sopA and sopE2 is functionally linked and contributes to virulence of Salmonella enterica serovar Typhi

Valenzuela, LM; Hidalgo, AA; Rodríguez L.; urrutia im; Ortega, AP; villagra NA; Paredes Sabja D; Calderon, IL; Gil, F; Saavedra, CP; Mora, GC; Fuentes, JA.

Article ISI SCOPUS
INFECTION GENETICS AND EVOLUTION  (2015)

Spectral, theoretical characterization and antifungal properties of two phenol derivative Schiff bases with an intramolecular hydrogen bond

Carreno, A.; Gacitua, M; Paez-Hernandez, D; Polanco, R.; Preite, M; Fuentes, JA.; Mora, GC; Chavez, I; Arratia-Perez, R

Article ISI SCOPUS
New Journal of Chemistry  (2015)

stg fimbrial operon from S. Typhi STH2370 contributes to association and cell disruption of epithelial and macrophage-like cells

Berrocal, L; Fuentes, JA.; Trombert, AN; Jofre, MR; villagra NA; Valenzuela, LM; Mora, GC

Article ISI SCOPUS
Biological Research  (2015)

Draft Genome Sequence of Salmonella enterica Serovar Typhi Strain STH2370

Valenzuela C.; Ugalde, J. A.; Mora, G. C.; Álvarez S.; Contreras I.; Santiviago, C. A.

Article SCOPUS
Genome Announcements  (2014)

RpoS integrates CRP, Fis, and PhoP signaling pathways to control Salmonella Typhi hlyE expression

Jofre, MR; Rodriguez, LM; villagra NA; Hidalgo, AA; Mora, GC; Fuentes, JA.

Article ISI SCOPUS
BMC MICROBIOLOGY  (2014)

Salmonella Typhi shdA: Pseudogene or allelic variant?

urrutia im; Fuentes, JA.; Valenzuela, LM; Ortega, AP; Hidalgo, AA; Mora, GC

Article ISI SCOPUS
INFECTION GENETICS AND EVOLUTION  (2014)

Porin alterations present in non-carbapenemase-producing Enterobacteriaceae with high and intermediate levels of carbapenem resistance in Chile

Wozniak A.; Villagra N.A.; Undabarrena, A.; Gallardo N.; Keller, N; Moraga M.Á.; Román J.C.; Mora, G. C.; Garcia P.

Article ISI SCOPUS
Journal of Medical Microbiology  (2012)

Synthesis of CdTe QDs/single-walled aluminosilicate nanotubes hybrid compound and their antimicrobial activity on bacteria

Geraldo D.A.; Arancibia-Miranda, N; Villagra N.A.; Mora, G. C.; Arratia-Perez, R

Article ISI SCOPUS
Journal of Nanoparticle Research  (2012)

The carbon source influences the efflux pump-mediated antimicrobial resistance in clinically important Gram-negative bacteria

Villagra N.A.; Fuentes, J. A.; Jofre M.R.; Hidalgo, A. A.; Garcia P.; Mora, G. C.

Article ISI SCOPUS
Journal of Antimicrobial Chemotherapy  (2012)

A holin remnant protein encoded by STY1365 is involved in envelope stability of Salmonella enterica serovar Typhi

Rodas, PI; Trombert, AN; Mora, GC

Article ISI SCOPUS
FEMS Microbiology Letters  (2011)

Response regulator ArcA of Salmonella enterica serovar Typhimurium downregulates expression of OmpD, a porin facilitating uptake of hydrogen peroxide

Calderon I.L.; Morales E. ; Caro N.J.; Chahuan C.A.; Collao B; Gil, F; Villarreal J.M.; IPINZA, F.; Mora, G. C.; Saavedra, C. P.

Article ISI SCOPUS
RESEARCH IN MICROBIOLOGY  (2011)

Modified Intracellular-Associated Phenotypes in a Recombinant Salmonella Typhi Expressing S. Typhimurium SPI-3 Sequences

Retamal P.; Castillo-Ruiz, M; villagra NA; Morgado, J; Mora, GC

Article ISI SCOPUS
PLOS ONE  (2010)

S. Typhimurium sseJ gene decreases the S. Typhi cytotoxicity toward cultured epithelial cells

Trombert, AN; Berrocal, L; Fuentes, JA.; Mora, GC

Article ISI SCOPUS
BMC Microbiology  (2010)

Salmonella enterica serovar Typhi has a 4.1 kb genetic island inserted within the sapABCDF operon that causes loss of resistance to the antimicrobial peptide protamine

Rodas, PI; Contreras, I; Mora, GC

Article ISI SCOPUS
Journal of Antimicrobial Chemotherapy  (2010)

Characterization of MgtC, a Virulence Factor of Salmonella enterica Serovar Typhi

Retamal P.; Castillo-Ruiz, M; Mora, GC

Article ISI SCOPUS
PLOS ONE  (2009)

RpoS- and Crp-dependent transcriptional control of Salmonella Typhi taiA and hlyE genes: role of environmental conditions

Fuentes, JA.; Jofre, MR; villagra NA; Mora, GC

Article ISI SCOPUS
RESEARCH IN MICROBIOLOGY  (2009)

SmvA, and not AcrB, is the major efflux pump for acriflavine and related compounds in Salmonella enterica serovar Typhimurium

villagra NA; Hidalgo, AA; Santiviago, CA; Saavedra, CP; Mora, GC

Article ISI SCOPUS
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY  (2008)

The capacity of Salmonella to survive inside dendritic cells and prevent antigen presentation to T cells is host specific

Bueno, SM; Gonzalez PA; Carreno, LJ; Tobar, JA; Mora, GC; Pereda, CJ; SALAZAR ONFRAY F; Kalergis, AM

Article ISI SCOPUS
IMMUNOLOGY  (2008)

The Salmonella Typhi hlyE gene plays a role in invasion of cultured epithelial cells and its functional transfer to S. Typhimurium promotes deep organ infection in mice

Fuentes, JA.; Villagra, N; Castillo-Ruiz, M; Mora, GC

Article ISI SCOPUS
RESEARCH IN MICROBIOLOGY  (2008)

The ompW (porin) gene mediates methyl viologen (paraquat) efflux in Salmonella enterica serovar Typhimurium

Gil, F; IPINZA, F.; Fuentes, J; Pumeron, P; Villarreal, JM; Aspée A.; Mora, GC; Vásquez CC; SAAVEDRA, C

Article ISI SCOPUS
RESEARCH IN MICROBIOLOGY  (2007)

The cotranscribed Salmonella enterica sv. Typhi tsx and impX genes encode opposing nucleoside-specific import and export proteins

Bucarey, SA; villagra NA; Fuentes, JA.; Mora, GC

Article ISI SCOPUS
GENETICS  (2006)

Genetic analysis of antibiotic-resistance determinants in multidrug-resistant Shigella strains isolated from Chilean children

Toro, CS; Farfan, M; Contreras, I; Flores, O; Navarro, N; Mora, GC; PRADO, V

Article ISI SCOPUS
EPIDEMIOLOGY AND INFECTION  (2005)

The Salmonella enterica serovar Typhi tsx gene, encoding a nucleoside-specific porin, is essential for prototrophic growth in the absence of nucleosides

Bucarey, SA; villagra NA; Martinic, MP; Trombert, AN; Santiviago, CA; Maulen, NP; Youderian, P; Mora, GC

Article ISI SCOPUS
INFECTION AND IMMUNITY  (2005)

Insertions of mini-Tn10 transposon T-POP in Salmonella enterica sv. typhi

Hidalgo, AA; Trombert, AN; Castro-Alonso, JC; Santiviago, CA; Tesser, BR; Youderian, P; Mora, GC

Article ISI SCOPUS
GENETICS  (2004)

Precise Excision of the Large Pathogenicity Island, SPI7, in Salmonella enterica Serovar Typhi

Bueno, S. M.; Santiviago, C. A.; Murillo A.A.; Fuentes, J. A.; Trombert, A. N.; Rodas P.I.; Mora, G. C.; Youderian, P

Article SCOPUS
JOURNAL OF BACTERIOLOGY  (2004)

Global regulation of the Salmonella enterica serovar Typhimurium major porin, OmpD

Santiviago, CA; Toro, CS; Hidalgo, AA; Youderian, P; Mora, GC

Article ISI SCOPUS
JOURNAL OF BACTERIOLOGY  (2003)

Prophage contribution to bacterial population dynamics

Bossi L.; Fuentes, JA.; Mora, G; Figueroa-Bossi, N

Article ISI SCOPUS
JOURNAL OF BACTERIOLOGY  (2003)

The Salmonella enterica sv. Typhimurium smvA, yddG and ompD (porin) genes are required for the efficient efflux of methyl viologen

Santiviago, CA; Fuentes, JA.; Bueno, SM; Trombert, AN; Hildago, AA; Socias, LT; Youderian, P; Mora, GC

Article ISI SCOPUS
MOLECULAR MICROBIOLOGY  (2002)

A chromosomal region surrounding the ompD porin gene marks a genetic difference between Salmonella typhi and the majority of Salmonella serovars

Santiviago, CA; Toro, CS; Bucarey, SA; Mora, GC

Article ISI
MICROBIOLOGY-SGM  (2001)

BookSection (1)

Unnecessary baggage

Maloy G; Mora G

BookSection
 (2012)

Proyecto (6)

Loss of key functions drive Salmonella Typhi adaptive pathogenesis to humans

Guido C Mora

Proyecto
 (2015)

Formulación de un Compuesto Farmacéutico efectivo contra Bacterias Multirresistente de Importancia Médica

Guido Mora

Proyecto
 (2012)

Identification and analysis of pseudogenes involved in the evolutionary adaptation of Salmonella Typhi to the human host

Guido Mora

Proyecto
 (2011)

Salmonella enterica serovar Typhi, patógeno específico y crónico del ser humano: Caracterización de mecanismos moleculares de su patogenicidad

Guido Mora

Proyecto
 (2006)

Participación de las proteínas de membrana externa OmpD y OmpW de Salmonella enterica serovar Typhimurium en la expulsión de sustancias toxicas desde la célula

Guido Mora

Proyecto
 (2005)

Genómica funcional en Salmonella Typhi: Evaluación del rol de regiones cromosomales serovar-específicas en patogenicidad y especificidad de hospedero

Mora, Guido

Proyecto
 (2002)

43
Guido Mora

Académico/Investigador

Facultad Ciencias de la Salud

Universidad SEK

Santiago, Chile

18
Juan Fuentes

Académico

Ciencias Biológicas

Universidad Andrés Bello

Santiago, Chile

14
Nicolás Villagra

Profesor Asistente

Tecnología Médica

UNIVERSIDAD ANDRES BELLO

Santiago, Chile

10
Alejandro Hidalgo

Associate Professor

Escuela de Química y Farmacia

Universidad Andres Bello

Santiago, Chile

6
Claudia Saavedra

Full Professor

Departmento de Ciencias de la Vida

UNIVERSIDAD ANDRÉS BELLO

Santiago, Chile

4
Matías Jofré

Académico

Universidad Finis Terrae

Santiago, Chile

3
Ítalo Urrutia

Profesor Asistente

Universidad Autónoma de Chile

Santiago, Chile

3
Fernando Gil

Associate Professor

Biological Sciences

UNIVERSIDAD ANDRES BELLO

Santiago, Chile

3
Liliana Berrocal

Académico

UNIVERSIDAD FINIS TERRAE

Santiago, Chile

3
Mario Castillo

Coordinador área Microbiología e Inmunología

Ciencias Químicas y Biológicas

Universidad Bernardo O'Higgins

Santiago, Chile

3
Ramiro Arratia

DIRECTOR DOCTORADO

CIENCIAS QUIMICAS

UNIVERSIDAD ANDRES BELLO

Santiago, Chile

3
Susan Bueno

Profesor Asociado

Genética Molecular y Microbiología

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

Santiago, Chile

3
IVAN CALDERON

Associate Professor / Principal Investigator/ Master in Biotechnology & Life Sciences Director

Biological Sciences

UNIVERSIDAD ANDRÉS BELLO

SANTIAGO, Chile

3
SERGIO BUCAREY

Profesor Asociado

Departamento de Ciencias Biológicas Animales

UNIVERSIDAD DE CHILE, FACULTAD DE CIENCIAS VETERINARIAS Y PECUARIAS

Santiago, Chile

3
Patricia García

Jefe de Laboratorio de Microbiologia

Escuela de Medicina

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE, LABORATORIO DE MICROBIOLOGÍA

Santiago, Chile

2
Alexander Carreño

Profesor asistente

Doctorado en Fisico Química Molecular

Universidad Andrés Bello

Santiago, Chile

2
Patricio Retamal

Profesor Asistente

Medicina Preventiva Animal

FACULTAD DE CIENCIAS VETERINARIAS Y PECUARIAS, UNIVERSIDAD DE CHILE

Santiago, Chile

2
Alexander Carreño

Profesor asistente

Center of Applied Nanoscience

UNIVERSIDAD ANDRES BELLO

Santiago, Chile

2
Daniel Paredes

Associate Professor

Department of Biological Sciences

Universidad Andrés Bello

Santiago, Chile

2
Manuel Gacitúa

Profesor asistente

Departamento de Química de los Materiales

Universidad de Santiago de Chile

Santiago, Chile

1
Marcelo Preite

Associate Professor

Organic Chemistry

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

1
Rubén Polanco

Associate Professor

Biological Sciences

UNIVERSIDAD ANDRÉS BELLO (UNAB)

SANTIAGO, Chile

1
Leandro Carreño

Profesor Asistente

Instituto de Ciencias Biomédicas

Universidad de Chile

Santiago, Chile

1
EDUARDO HUGO MORALES SIERRA 

1
Pablo González

Associate Professor

Molecular Genetics and MIcrobiology

Pontificia Universidad Católica de Chile

Santiago, Chile

1
Aniela Wozniak

Coordinador de Investigación

Dept Laboratorios Clínicos

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

1
Maria Otero

Profesor Asociado

UNIVERSIDAD ANDRES BELLO

Santiago, Chile

1
Nicolás Arancibia

Profesor Asistente

Universidad de Santiago

Santiago, Chile

1
Alexis Kalergis

Full Professor

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE. FACULTAD DE CIENCIAS BIOLÓGICAS

Santiago, Chile

1
Annette Trombert

Directora de Escuela

Biotecnología

UNIVERSIDAD MAYOR, INSTITUTO DE BIOTECNOLOGÍA, CENTRO DE GENÓMICA Y BIOINFORMÁTICA

Santiago, Chile

1
Dayán Páez

Profesor Asociado

Facultad de Ciencias Exactas

Universidad Andrés Bello

Santiago, Chile

1
Nelson Caro

Director de Centro

Centro de Investigación Austral Biotech

Universidad Santo Tomás

Santiago, Chile

1
Juan Castro

Researcher

Universidad de Chile

Santiago, Chile

1
Marco Soto

Profesor Asociado

Química Física

Pontificia Universidad Católica de Chile

Santiago, Chile

1
Niurka Navarro

Gerente

Innovación y Desarrollo

Nutri-Omics SpA

Samtiago, Chile

1
ALEXIS ASPEE

Profesor Titular

Ciencias del Ambiente

UNIVERSIDAD DE SANTIAGO DE CHILE

Santiago, Chile

1
Mauricio Farfán

Profesor Asociado

Departamento de Pediatria y Cirugia Infantil, Hospital Dr. Luis Calvo Mackenna, Facultad de Medicina, Universidad de Chile

Universidad de Chile

Providencia, Chile