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Nicolás Alberto Villagra Marín

Profesor Asistente

UNIVERSIDAD ANDRES BELLO

Santiago, Chile

Genetic basis of bacterial resistance to antibiotics; Search for natural compounds with antimicrobial activity; Clinical microbiology; Pathogenesis in Salmonella Genetic Molecular in bacteria

Microbiología, Universidad Andrés Bello. Chile, 2014

Profesor Asistente Full Time

UNIVERSIDAD ANDRES BELLO

Medicina

Santiago, Chile

2015 - A la fecha

Profesor Asistente Full Time

Universidad Andrés Bello

Santiago, Chile

2015 - A la fecha

Tutor de 1 estudiante de Magister, Ingeniería en Biotecnología, UNAB
Co-tutor de 1 estudiante de Magister, Ingeniería en Biotecnología, UNAB
Co-tutor de 2 estudiantes de Magister en Bioquímica, UNAB
Tutor, 15 estudiantes de Unidad de Investigación, Tecnología Médica, UNAB

Investigador Principal proyecto FONDEF IDeA Ca12I10110, 2013-2014

ASM International Fellowships for Latin American and the Caribbean

American Society Microbiology

Estados Unidos, 2012

to perform research at the CNRS. Centre de Génétique Moléculaire. Département Expression des Gènes. Paris. Francia.


Inactivation of Glutamine Synthetase-Coding Gene glnA Increases Susceptibility to Quinolones Through Increasing Outer Membrane Protein F in Salmonella enterica Serovar Typhi Mora A.Y.; Saavedra, C. P.; Villagra N.A.; Mora, G. C.; Hidalgo, A. A. Article ISI SCOPUS FRONTIERS IN MICROBIOLOGY (2020)
Cysteine auxotrophy drives reduced susceptibility to quinolones and paraquat by inducing the expression of efflux-pump systems and detoxifying enzymes in S. Typhimurium Villagra NA, Valenzuela LM, Mora AY, Millanao AR, Saavedra CP, Mora GC, Hidalgo AA. Article ISI SCOPUS BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2019)
Global phylogeography and ancient evolution of the widespread human gut virus crAssphage Vega A.A.; Norman H.M.; Ohaeri M.; Levi K.; Dinsdale E.A.; Cinek O.; McNair K.; Barr J.J.; Bibby K.; Brouns S.J.J.; et al. Article ISI SCOPUS NATURE MICROBIOLOGY (2019)
The efflux pump inhibitor phenylalanine-arginine beta-naphthylamide (PA beta N) increases resistance to carbapenems in Chilean clinical isolates of KPC-producing Klebsiella pneumoniae Lima C.A.; Villagra, N Article ISI SCOPUS JOURNAL OF GLOBAL ANTIMICROBIAL RESISTANCE (2018)
Xylose Improves Antibiotic Activity of Chloramphenicol and Tetracycline against and in a Murine Model of Skin Infection. Hidalgo, Alejandro A; Arias, Ángel J; Fuentes, Juan A; García, Patricia; Mora, Guido C; Villagra, Nicolás A Article The Canadian journal of infectious diseases & medical microbiology = Journal canadien des maladies infectieuses et de la microbiologie medicale (2018)
[Prevalence of Bartonella henselae in blood donors and risk of blood transmission in Chile]. Núñez, M Antonieta; Contreras, Karla; Depix, M Soledad; Geoffroy, Enrique; Villagra, Nicolás; Mellado, Sandra; Salinas, Ana M Article Revista chilena de infectologia => organo oficial de la Sociedad Chilena de Infectologia (2017)
A conditionally lethal mutant of Salmonella Typhimurium induces a protective response in mice Hidalgo, AA; Jerez, SA; Fuentes, JA; Mora, GC Article ISI SCOPUS BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2016)
Expression of IroN, the salmochelin siderophore receptor, requires mRNA activation by RyhB small RNA homologues Balbontín R.; Villagra, N; Pardos de la Gándara M.; Mora, G; Bossi L. Article ISI SCOPUS MOLECULAR MICROBIOLOGY (2016)
Lose to win: marT pseudogenization in Salmonella enterica serovar Typhi contributed to the surV-dependent survival to H2O2, and inside human macrophage-like cells Article INFECTION GENETICS AND EVOLUTION (2016)
SPI-9 of Salmonella enterica serovar Typhi is constituted by an operon positively regulated by RpoS and contributes to adherence to epithelial cells in culture Article ISI SCOPUS MICROBIOLOGY-SGM (2016)
Pseudogenization of sopA and sopE2 is functionally linked and contributes to virulence of Salmonella enterica serovar Typhi. Valenzuela, L M; Hidalgo, A A; Rodríguez, L; Urrutia, I M; Ortega, A P; Villagra, N A; Paredes-Sabja, D; Calderón, I L; Gil, F; Saavedra, C P; Mora, G C; Fuentes, J A Article Infection, genetics and evolution => journal of molecular epidemiology and evolutionary genetics in infectious diseases (2015)
stg fimbrial operon from S. Typhi STH2370 contributes to association and cell disruption of epithelial and macrophage-like cells Berrocal, L; Fuentes, JA; Trombert, AN; Jofre, MR; Mora, GC Article ISI SCOPUS Biological Research (2015)
RpoS integrates CRP, Fis, and PhoP signaling pathways to control Salmonella Typhi hlyE expression Jofre, MR; Rodriguez, LM; Hidalgo, AA; Mora, GC; Fuentes, JA Article ISI SCOPUS BMC MICROBIOLOGY (2014)
Porin alterations present in non-carbapenemase-producing Enterobacteriaceae with high and intermediate levels of carbapenem resistance in Chile Wozniak A.; Villagra N.A.; Undabarrena, A.; Gallardo, N.; Keller, N; Moraga M.Á.; Mora, G. C.; Garcia, P. Article ISI SCOPUS Journal of Medical Microbiology (2012)
Synthesis of CdTe QDs/single-walled aluminosilicate nanotubes hybrid compound and their antimicrobial activity on bacteria Geraldo D.A.; Arancibia-Miranda, N; Villagra N.A.; Mora, G. C.; Arratia-Perez, R Article ISI SCOPUS Journal of Nanoparticle Research (2012)
The carbon source influences the efflux pump-mediated antimicrobial resistance in clinically important Gram-negative bacteria Villagra N.A.; Fuentes, J. A.; Hidalgo, A. A.; Garcia, P.; Mora, G. C. Article ISI SCOPUS Journal of Antimicrobial Chemotherapy (2012)
Modified Intracellular-Associated Phenotypes in a Recombinant Salmonella Typhi Expressing S. Typhimurium SPI-3 Sequences Retamal, P; Castillo-Ruiz, M; Morgado, J; Mora, GC Article ISI SCOPUS PLOS ONE (2010)
RpoS- and Crp-dependent transcriptional control of Salmonella Typhi taiA and hlyE genes: role of environmental conditions Fuentes, JA; Jofre, MR; Mora, GC Article ISI SCOPUS RESEARCH IN MICROBIOLOGY (2009)
SmvA and not AcrB, is the major efflux pump for acriflavine and related compounds in Salmonella enterica serovar Typhimurium Nicolás A. Villagra, Alejandro Hidalgo, Carlos Santiviago, and Guido C Mora. Article JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY (2008)
The Salmonella Typhi hlyE gene plays a role in invasion of cultured epithelial cells and its functional transfer to S. Typhimurium promotes deep organ infection in mice Fuentes, JA; Villagra, N; Castillo-Ruiz, M; Mora, GC Article ISI SCOPUS RESEARCH IN MICROBIOLOGY (2008)
The cotranscribed Salmonella enterica sv. Typhi tsx and impX genes encode opposing nucleoside-specific import and export proteins Bucarey, SA; Fuentes, JA; Mora, GC Article ISI SCOPUS GENETICS (2006)
The Salmonella enterica serovar Typhi tsx gene, encoding a nucleoside-specific porin, is essential for prototrophic growth in the absence of nucleosides Bucarey, SA; Martinic, MP; Trombert, AN; Santiviago, CA; Maulen, NP; Youderian, P; Mora, GC Article ISI SCOPUS INFECTION AND IMMUNITY (2005)


LOSS OF KEY FUNCTIONS DRIVES SALMONELLA TYPHI ADAPTIVE PATHOGENESIS TO HUMANS FONDECYT (1151393) Proyecto 2015-2019 Coinvestigador(a)
Diseño de una formulación para uso farmacéutico efectiva contra bacterias multirresistentes de importancia médica FONDECYT (CA12I10110) Proyecto 2011-2012 Inv. Responsable
IDENTIFICATION AND ANALYSIS OF PSEUDOGENES INVOLVED IN THE EVOLUTIONARY ADAPTATION OF SALMONELLA TYPHI TO THE HUMAN HOST FONDECYT (1110120) Proyecto 2011-2015 Tesista