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Leandro Javier Carreño Marquez

Profesor Asistente

Universidad de Chile

Santiago, Chile

Líneas de Investigación


Líneas de investigación: - Modulacion de la respuesta inmune por glycolipidos - Celulas natural killer T - Inflamacion Disciplina Principal: Inmunología

Educación

  •  Bioquimico, PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE. Chile, 2006
  •  Licenciado en Bioquimica, PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE. Chile, 2004
  •  Doctorado en Ciencias Biologicas Mencion Genetica Molecular y Microbiologia, PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE. Chile, 2010
  •  Magister en Ciencias Biologicas, PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE. Chile, 2007

Experiencia Académica

  •   Tesista de Pregrado Full Time

    PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

    Santiago , Chile

    2004 - 2006

  •   Tesista de Doctorado Full Time

    PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

    Santiago , Chile

    2006 - 2010

  •   Profesor Asistente Full Time

    UNIVERSIDAD DE CHILE

    Facultad de Medicina

    Santiago, Chile

    2011 - A la fecha

  •   Postdoctorado Full Time

    ALBERT EINSTEIN COLLEGE OF MEDICINE

    New York, Estados Unidos

    2012 - 2016

Experiencia Profesional

  •   Especialista de Aplicaciones Full Time

    BD Bioscience Chile

    Santiago , Chile

    2005 - 2005

  •   Investigador Full Time

    Consorcio Biotecnología de Biomedicina Molecular S.A.

    Santiago , Chile

    2010 - 2011

Premios y Distinciones

  •   Premio Padre Hurtado

    PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

    Chile, 2000

    Beca para estudios gratuitos por excelente rendimiento escolar y en las pruebas de selección universitarias

  •   Premio a la Mejor Tesis

    Asociación Nacional de Estudiantes de Bioquímica

    Chile, 2005

    Premio a la mejor presentacion en el congreso de la ANEB 2005

  •   Premio a la Mejor Tesis de Pregrado

    Sociedad de Biología Celular de Chile

    Chile, 2006

    Premio a la Mejor Tesis de Pregrado o Magister 2006

  •   Beca Conicyt de Doctorado

    COMISION NACIONAL DE INVESTIGACION CIENTIFICA Y TECNOLOGICA

    Chile, 2006

    Beca de Doctorado

  •   Medalla Hermann Niemayer

    Sociedad de Bioquímica y Biología Molecular de Chile

    Chile, 2010

    Medalla para el mejor estudiante de Doctorado de las áreas de la Bioquímica y Biología Molecular


 

Article (36)

Contribution of NKT cells to the immune response and pathogenesis triggered by respiratory viruses
Genomic characterization of the non-O1/non-O139 Vibrio cholerae strain that caused a gastroenteritis outbreak in Santiago, Chile, 2018
Ten years of molecular epidemiology surveillance of Listeria monocytogenes in Chile 2008–2017.
Association Between Plasma Antibody Responses and Risk for Cryptococcus-Associated Immune Reconstitution Inflammatory Syndrome
Antibody and B Cell Subset Perturbations in Human Immunodeficiency Virus-Uninfected Patients With Cryptococcosis
Dual Modifications of alpha-Galactosylceramide Synergize to Promote Activation of Human Invariant Natural Killer T Cells and Stimulate Anti-tumor Immunity
Dual Modifications of alpha-Galactosylceramide Synergize to Promote Activation of Human Invariant Natural Killer T Cells and Stimulate Anti-tumor Immunity (vol 25, pg 571, 2018)
Enhanced control of Mycobacterium tuberculosis extrapulmonary dissemination in mice by an arabinomannan-protein conjugate vaccine
Enhanced control of Mycobacterium tuberculosis extrapulmonary dissemination in mice by an arabinomannan-protein conjugate vaccine.
Topical nitric oxide releasing nanoparticles are effective in a murine model of dermal Trichophyton rubrum dermatophytosis
Modulation of antigen processing by haem-oxygenase 1. Implications on inflammation and tolerance
Suppression of autophagy and antigen presentation by Mycobacterium tuberculosis PE_PGRS47
Synthetic glycolipid activators of natural killer T cells as immunotherapeutic agents
The Type of Growth Medium Affects the Presence of a Mycobacterial Capsule and Is Associated With Differences in Protective Efficacy of BCG Vaccination Against Mycobacterium tuberculosis
A Single Subset of Dendritic Cells Controls the Cytokine Bias of Natural Killer T Cell Responses to Diverse Glycolipid Antigens
Direct incorporation of the NKT-cell activator alpha-galactosylceramide into a recombinant Listeria monocytogenes improves breast cancer vaccine efficacy
Improving Mycobacterium bovis Bacillus Calmette-Guerin as a Vaccine Delivery Vector for Viral Antigens by Incorporation of Glycolipid Activators of NKT Cells
Mycobacterial Membrane Vesicles Administered Systemically in Mice Induce a Protective Immune Response to Surface Compartments of Mycobacterium tuberculosis
Carbon monoxide decreases endosome-lysosome fusion and inhibits soluble antigen presentation by dendritic cells to T cells
Carbon monoxide exposure improves immune function in lupus-prone mice
Gestational Hypothyroidism Increases the Severity of Experimental Autoimmune Encephalomyelitis in Adult Offspring
Human CD1d knock-in mouse model demonstrates potent antitumor potential of human CD1d-restricted invariant natural killer T cells
Haem oxygenase 1 expression is altered in monocytes from patients with systemic lupus erythematosus
Hypothyroidism in the Adult Rat Causes Incremental Changes in Brain-Derived Neurotrophic Factor, Neuronal and Astrocyte Apoptosis, Gliosis, and Deterioration of Postsynaptic Density
Contribution of dendritic cell/T cell interactions to triggering and maintaining autoimmunity
Induction of Tolerogenic Dendritic Cells by NF-kappa B Blockade and Fc gamma Receptor Modulation
Modulation of the dendritic cell-T-cell synapse to promote pathogen immunity and prevent autoimmunity
Salmonella pathogenicity island 1 differentially modulates bacterial entry to dendritic and non-phagocytic cells.
T-cell antagonism by short half-life pMHC ligands can be mediated by an efficient trapping of T-cell polarization toward the APC
Disease activity in systemic lupus erythematosus is associated with an altered expression of low-affinity Fc gamma receptors and costimulatory molecules on dendritic cells
The duration of TCR/pMHC interactions regulates CTL effector function and tumor-killing capacity
Respiratory syncytial virus impairs T cell activation by preventing synapse assembly with dendritic cells
The capacity of Salmonella to survive inside dendritic cells and prevent antigen presentation to T cells is host specific
The half-life of the T-cell receptor/peptide-major histocompatibility complex interaction can modulate T-cell activation in response to bacterial challenge
Virulent Salmonella enterica serovar typhimurium evades adaptive immunity by preventing dendritic cells from activating T cells
T cell receptor binding kinetics required for T cell activation depend on the density of cognate ligand on the antigen-presenting cell

Abstract (1)

A novel form of T cell antagonism by trapping of immunological synapse

Editorial (1)

Targeting Innate Immune Cells for Immunotherapy

Proyecto (13)

Immune response and gastric damage transition from child to adult in symptomatic Helicobacter pylori infected individuals: dynamic and host/pathogen/microbiota determinants
Papel de la inmunoglobulina g (igg) en la inmunidad de mucosa contra escherichia coli enterohemorrágica en el modelo ratón
Elaboración y caracterización de liposomas anti-inflamatorios como herramienta para tratar alergias
Elaboración y caracterización de liposomas anti-inflamatorios como herramienta para tratar alergias
Elaboration of liposomes targeting type-I and type-II natural killer T cells to enhance antibody production
Targeting type-I and type-II natural killer T cells to enhance effector and memory B cell responses
Instituto Milenio en Inmunología e Inmunoterapia
Instituto Milenio en Inmunología e Inmunoterapia
Modulation of T cells responses by activation of type I and type II Natural killer T cells using a partially humanized mouse model
Modulation of T cells responses by activation of type I and type II Natural killer T cells using a partially humanized mouse model
Non conventional antigen presenting cells modulate the activity of iNKT cells, CD4 T cells and regulatory T cells during allergy
IDENTIFICATION OF THE MECHANISMS USED BY THE RESPIRATORY SYNCYTIAL VIRUS (RSV) TO INTERFERE WITH THE FUNCTION OF DENDRITIC CELLS AND IMPAIR T CELL IMMUNITY IN THE HOST
MATERNAL HYPOTHYROXINEMIA INCREASES THE SUSCEPTIBILITY TO DEVELOP INFLAMMATORY DEMYELINATION IN THE OFFSPRING.

Review (13)

New Insights on the Role of Lipid Metabolism in the Metabolic Reprogramming of Macrophages
Assessing the Importance of Domestic Vaccine Manufacturing Centers: An Overview of Immunization Programs, Vaccine Manufacture, and Distribution
Innate immune cells for immunotherapy of autoimmune and cancer disorders
Activation mechanisms of invariant natural killer T cells (INKTs) [Mecanismos de ativação das células T assassinas naturais invariantes (INKT)] [Mecanismos de activación de las células T asesinas naturales invariantes (INKT)]
Current efforts and future prospects in the development of live mycobacteria as vaccines
Optimizing NKT cell ligands as vaccine adjuvants
Modulation of Tumor Immunity by Soluble and Membrane-Bound Molecules at the Immunological Synapse
Understanding respiratory syncytial virus infection to improve treatment and immunity
Respiratory syncytial virus infection and immunity
Local cytokine response upon respiratory syncytial virus infection
Virulence Mechanisms Displayed by Salmonella to Impair Dendritic Cell Function
Modulation of immunological synapse by membrane-bound and soluble ligands
Modulation of T cell function by TCR/pMHC binding kinetics
55
Leandro Carreño

Profesor Asistente

Instituto de Ciencias Biomédicas

Universidad de Chile

Santiago, Chile

24
Susan Bueno

Profesor Asociado

Genética Molecular y Microbiología

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

Santiago, Chile

19
Alexis Kalergis

Full Professor

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE. FACULTAD DE CIENCIAS BIOLÓGICAS

Santiago, Chile

17
Pablo González

Associate Professor

Molecular Genetics and MIcrobiology

Pontificia Universidad Católica de Chile

Santiago, Chile

14
Claudia Riedel

Full Professor

Life Sciences

Universidad Andres Bello

Santiago, Chile

3
Carolina Llanos

Associate Professor

Pontificia Universidad Católica de Chile

Santiago, Chile

3
David Montero

Investigador Postdoctoral

Programa Disciplinario de Inmunología. Facultad de Medicina.

Universidad de Chile

Santiago, Chile

3
roberto vidal

Head of Pathogenic Escherichia coli Laboratory

Director Microbiology and Mycology Program

UNIVERSIDAD DE CHILE

Santiago, Chile

3
Carolina Llanos

Profesor Asociado

Inmunología Clínica y Reumatología

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

Santiago, Chile

2
ERICK RIQUELME

ASSISTANT PROFESSOR

ENFERMEDADES RESPIRATORIAS

Pontificia Universidad Católica de Chile

SANTIAGO, Chile

1
Maria Opazo

Profesor honorarios

Ciencias Biologicas

UNIVERSIDAD ANDRES BELLO

Santiago, Chile

1
Esteban Aliaga

Profesor

Kinesiología

Universidad Católica el Maule

Talca, Chile

1
Eduardo Leiva

Profesor Asistente

Departamento de Ingeniería Hidráulica y Ambiental/ Departamento de Química Inorgánica

Pontificia Universidad Católica de Chile, Facultad de Química, Escuela de Ingeniería

Santiago, Chile

1
Carolina Prado

Investigador Joven

Fundacion Ciencia y Vida

Santiago, Chile

1
Felipe Court

Full Professor and Director

Center for Integrative Biology

Universidad Mayor

Huechuraba, Chile

1
Rodrigo Pacheco

Associate Investigator; Head of the Laboratory of Neuroimmunology

Fundación Ciencia para la Vida

Santiago, Chile

1
Claudio Figueroa

Profesor Asistente

Ciencias Biológicas y Quimicas

Universidad San Sebastian

Santiago, Chile

1
Margarita Lay

PROFESOR ASISTENTE

BIOTECNOLOGÍA

UNIVERSIDAD DE ANTOFAGASTA

ANTOFAGASTA, Chile

1
Emma Rey

Professor/Researcher

Instituto de Ciencias e Innovación en Medicina (ICIM)

Universidad del Desarrollo

Santiago, Chile

1
David Naranjo

Profesor titular

Neurociencia

Universidad de Valparaíso

VALPARAISO, Chile

1
Nayaret Chamorro

Investigadora

Centro de Biologia Integrativa

Biome Therapeutics/Universidad Mayor

Santiago, Chile

1
Alfredo Criollo

Assistant professor

Research Institute in Dental Sciences

Facultad de Odontología, Universidad de Chile

Santiago, Chile

1
Guido Mora

Académico/Investigador

Facultad Ciencias de la Salud

Universidad SEK

Santiago, Chile

1
Felipe Tapia

Líder de grupo

Bioprocess Engineering

Max Planck Institute for Dynamics of Complex Technical Systems

Magdeburg, Alemania