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Margarita Kam-lem Lay Remolcoi

PROFESOR ASISTENTE

UNIVERSIDAD DE ANTOFAGASTA

ANTOFAGASTA, Chile

Estudio de mecanismos moleculares de la respuesta inmune y la patogénesis después de infecciones con el Virus Respiratorio Sincicial, el Metapneumovirus humano y los Norovirus humanos; desarrollo de vacunas y productos biotecnológicos biomédicos.

BIOLOGICAL SCIENCES , PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE. Chile, 1994
BIOLOGY, WASHINGTON UNIVERSITY IN ST. LOUIS. Estados Unidos, 2002
MOLECULAR VIROLOGY AND MICROBIOLOGY, BAYLOR COLLEGE OF MEDICINE. Estados Unidos, 2011

PROFESIONAL DE LABORATORIO Full Time

UNIVERSIDAD DE CHILE

MEDICINA

SANTIAGO, Chile

1995 - 1996
RESERACH ASSISTANT Full Time

WASHINGTON UNIVERSITY IN ST. LOUIS

BIOLOGICAL SCIENCES

ST LOUIS, Estados Unidos

1997 - 2000
RESEARCH ASSISTANT Full Time

WASHINGTON UNIVERSITY IN ST. LOUIS

MEDICINE

ST LOUIS, Estados Unidos

2000 - 2003
POSTDOCTORADO Full Time

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

CIENCIAS BIOLÓGICAS

SANTIAGO, Chile

2011 - 2015
PROFESOR ASISTENTE Full Time

UNIVERSIDAD DE ANTOFAGASTA

CIENCIAS DEL MAR Y RECURSOS BIOLÓGICOS

ANTOFAGASTA, Chile

2016 - A la fecha

PROFESOR ASISTENTE Full Time

UNIVERSIDAD DE ANTOFAGASTA

ANTOFAGASTA, Chile

2016 - A la fecha

Thesis Students:
Undergraduate:
- Macarena Juárez, Medical Technology, Universidad de Antofagasta
- Bayron Bruna, Medical Technology, Universidad de Antofagasta
- Aura Jiménez, Medical Technology, Universidad de Antofagasta
- Marisela Ledezma, Medical Technology, Universidad de Antofagasta
- Brian Parra, Biotechnology, Universidad de Antofagasta.
Postgraduate:
- Andrea Avellanada, Program Master of Biomedical Sciences, Universidad de Antofagasta

Participation in Invited Seminars and Meetings
1. June 24-25, 2013: Institute Millennium of Immunology and Immunotherapy Annual
Meeting. Santiago, Chile.
2. November 21, 2013: Spring Symposium of Immunology, Pontificia Universidad
Católica de Chile. Santiago, Chile.
3. August 1, 2014: II Cycle of Seminars of the Center of Genomic and Bioinformatics
at the Universidad Mayor, Campus Huechuraba, Santiago, Chile.
4. August 20, 2014: Institute Millennium of Immunology and Immunotherapy Annual
Meeting. Santiago, Chile.
5. June 1-2, 2015: RSV Vaccine Workshop, National Institutes of Health, Bethesda,
Maryland, USA.
6. April 20, 2016: Seminar at the Department of Molecular Virology and Microbiology,
Baylor College of Medicine, Houston, Texas, USA.
7. October 09-13, 2016: 6th International Calicivirus Conference, Savannah, Georgia,
USA.
8. May 15?17, 2017: Workshop “FOCIS Goes South: Advances in Translacional and
Clinical Immunology”, Pontificia Universidad Católica de Chile. Santiago, Chile.
9. August 1-5, 2017: XXXIV National Congress of students of biochemistry and
related careers of 2017, Universidad de Antofagasta, Antofagasta, Chile.
10. November 14-17, 2017: XXXIX Chilean Congress of Microbiology, La Serena,
Chile.
11. December 1, 2017: II Simposio de Tendencias en Ciencias Farmacéuticas: "Cómo
convivir con virus y bacteria, los desafíos del siglo XXI, Universidad Católica del Norte, Antofagasta

MARGARITA LAY

BILL AND MELINDA GATES FOUNDATION

Estados Unidos, 2015

Young Investigator award recipient of IMMUNOCOLOMBIA 2015, 11th Congress of the Latin American Association of the Bill and Melinda Gates Foundation in Immunology (ALAI) and 10th Colombian Congress of Allergy, Asthma and Immunology (ACCAI). Medellin, October 13-16, 2015
MARGARITA LAY

American Society for Virology

Estados Unidos, 2009

Student travel award recipient of the AAI to attend the American Society for Virology 28th annual meeting at the University of British Columbia, Vancouver, BC, Canada, July 11-15th. 2009


Modulation of Host Immunity by Human Respiratory Syncytial Virus Virulence Factors: A Synergic Inhibition of Both Innate and Adaptive Immunity Canedo-Marroquín, Gisela; Acevedo-Acevedo, Orlando; Rey-Jurado, Emma; Saavedra, Juan M.; Lay, Margarita K.; Bueno, Susan M.; Riedel, Claudia A.; Kalergis, Alexis M. Article ISI SCOPUS FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY (2017)
Aberrant T cell immunity triggered by human Respiratory Syncytial Virus and Human Metapneumovirus infection. González AE; Lay MK; Jara EL; Espinoza JA; Gómez RS; Soto J; Rivera CA; Abarca K; Bueno SM; Riedel CA; Kalergis AM Article Virulence (2016)
New insights on the viral and host factors contributing to the airway pathogenesis caused by the respiratory syncytial virus. Lay, Margarita K; Bueno, Susan M; Gálvez, Nicolás; Riedel, Claudia A; Kalergis, Alexis M Article Critical reviews in microbiology (2016)
Replication of human norovirus RNA in mammalian cells reveals a lack of interferon response Qu, Lin; Murakami Kosuke; Broughman James R; Lay Margarita K; Guix, Susana; Tenge Victoria R; Atmar Robert L; Estes, Mary K Article JOURNAL OF VIROLOGY (2016)
Elevated IL-3 and IL-12p40 levels in the lower airway of infants with RSV-induced bronchiolitis correlate with recurrent wheezing. Bertrand, Pablo; Lay, Margarita K; Piedimonte, Giovanni; Brockmann, Pablo E; Palavecino, Christian E; Hernández, Jury; León, Miguel A; Kalergis, Alexis M; Bueno, Susan M Article Cytokine (2015)
Human metapneumovirus infection activates the TSLP pathway that drives excessive pulmonary inflammation and viral replication in mice. Lay, Margarita K; Céspedes, Pablo F; Palavecino, Christian E; León, Miguel A; Díaz, Rodrigo A; Salazar, Francisco J; Méndez, Gonzalo P; Bueno, Susan M; Kalergis, Alexis M Article European journal of immunology (2015)
Inflammatory damage on respiratory and nervous systems due to hRSV infection. Bohmwald, Karen; Espinoza, Janyra A; Becerra, Daniela; Rivera, Katherine; Lay, Margarita K; Bueno, Susan M; Riedel, Claudia A; Kalergis, Alexis M Article Current opinion in immunology (2015)
Understanding Lung Immunopathology Caused by the Human Metapneumovirus: Implications for Rational Vaccine Design. Palavecino, Christian E; Cespedes, Pablo F; Lay, Margarita K; Riedel, Claudia A; Kalergis, Alexis M; Bueno, Susan M Article Critical reviews in immunology (2015)
Advances in understanding respiratory syncytial virus infection in airway epithelial cells and consequential effects on the immune response. Lay, Margarita K; González, Pablo A; León, Miguel A; Céspedes, Pablo F; Bueno, Susan M; Riedel, Claudia A; Kalergis, Alexis M Article Microbes and infection / Institut Pasteur (2013)
Lack of norovirus replication and histo-blood group antigen expression in 3-dimensional intestinal epithelial cells. Herbst-Kralovetz, Melissa M; Radtke, Andrea L; Lay, Margarita K; Hjelm, Brooke E; Bolick, Alice N; Sarker, Shameema S; Atmar, Robert L; Kingsley, David H; Arntzen, Charles J; Estes, Mary K; Nickerson, Cheryl A Article Emerging infectious diseases (2013)
Norwalk virus does not replicate in human macrophages or dendritic cells derived from the peripheral blood of susceptible humans. Lay, Margarita K; Atmar, Robert L; Guix, Susana; Bharadwaj, Uddalak; He, Hong; Neill, Frederick H; Sastry, K Jagannadha; Yao, Qizhi; Estes, Mary K Article Virology (2010)
Presence of wild-type and attenuated Salmonella enterica strains in brain tissues following inoculation of mice by different routes. Bollen, Wendy S; Gunn, Bronwyn M; Mo, Hua; Lay, Margarita K; Curtiss, Roy Article Infection and immunity (2008)
STAT1-dependent innate immunity to a Norwalk-like virus. Karst, Stephanie M; Wobus, Christiane E; Lay, Margarita; Davidson, John; Virgin, Herbert W Article Science (New York, N.Y.) (2003)
Heme Oxygenase-1 modulates Human Respiratory Syncytial Virus replication and lung pathogenesis during infection Espinoza, Janyra; León, Miguel; Céspedes, Pablo; Gómez, Roberto; Canedo-Marroquín, Gisela; Riquelme, Sebastían; Salazar-Echegarai, Francisco; Lay, Margarita; González, Pablo; Anegon, Ignacio; Riedel, Claudia; Bueno, Susan; Kalergis, Alexis. Article JOURNAL OF IMMUNOLOGY (0)


Human metapneumovirus infection induces expression of thymic stromal lymphopoetin and IL-33 in airway epithelial cells in vitro and lung infiltration of OX40L+DCs in vivo Lay M.; Cespedes P; Palavecino C.; Leon, M; Bueno, S; Kalergis, A Abstract ISI JOURNAL OF IMMUNOLOGY (2013)


Use of antibodies or neutralizing molecules against TSLP, OX40L and CD177, as a treatment to ameliorate the disease in patients infected with human Metapneumovirus LAY, MARGARITA Patent
Use of Molecular Biomarkers of IL-3, IL-33, IL-12p40 and TSLP to characterize the severity of respiratory infections for Respiratory Syncytial Virus and human Metapneumovirus LAY, MARGARITA Patent


CREACIÓN DEL ATACAMA DESERT VACCINE LABORATORY PARA DESARROLLAR VACUNAS EN ANTOFAGASTA LAY, MARGARITA; KALERGIS, ALEXIS Proyecto http://www.mercurioantofagasta.cl/impresa/2018/06/13/papel/ (2018)
Design of a Center for Manufacturing of Vaccines and Antibodies for Diagnostic and Therapy in the Metropolitan Region of Chile KALERGIS, ALEXIS; LAY, MARGARITA Proyecto http://inmunizacion.biologia.uc.cl/es/quienes-somos (2014)
Vaccine against Respiratory Syncytial Virus KALERGIS, ALEXIS; LAY, MARGARITA Proyecto (2013)
Estudio De La Respuesta Inmune Moduladas Por Celulas Epiteliales Humanas Hacia El Virus Respiratorio Sincicial Y El Metapneumovirus Humano LAY, MARGARITA; KALERGIS, ALEXIS Proyecto (2012)


Assessing the Importance of Domestic Vaccine Manufacturing Centers: An Overview of Immunization Programs, Vaccine Manufacture, and Distribution Rey-Jurado, E; Tapia, F; Munoz-Durango, N; Lay, MK; Carreno, LJ; Riedel, CA; Bueno, SM; Genzel, Y; Kalergis, AM Review ISI SCOPUS FRONTIERS IN IMMUNOLOGY (2018)