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Andres Alonso Herrada Hidalgo

Principal Investigator

Universidad Autónoma de Chile

Talca, Chile

Innate immune regulation in homeostatic and inflammatory conditions; dendritic cell/innate immune cell interaction and their effect over function; Innate immune dysfunction and their consequences in autoimmunity

Bioquimico, PONTIFICIA UNIVERSIDAD CATOLICA DE VALPARAISO. Chile, 2007
Doctor en Ciencias Biologicas Mencion Genetica Molecular y Microbiologia, PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE. Chile, 2011
Magister en Ciencias Biológicas, PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE. Chile, 2008

Postdoctoral fellow Full Time

St Jude Children´s Research Hospital

Memphis, Estados Unidos

2013 - 2017
Profesor asistente Full Time

Universidad Autónoma de Chile

Facultad de Ciencias de la Salud

Talca, Chile

2017 - A la fecha
Miembro del claustro académico del Doctorado en Ciencias Biomédicas Full Time

UNIVERSIDAD AUTONOMA DE CHILE

Talca, Chile

2018 - A la fecha
Miembro del claustro académico del Doctorado en Ciencias Biomédicas Other

UNIVERSIDAD DE TALCA

Talca, Chile

2023 - A la fecha

Postdoctoral training

Fundacion Ciencia y Vida

Chile

2011 - 2012
Postdoctoral Fellow Full Time

St Jude Chidren´s research Hospital

Estados Unidos

2012 - 2017


Palbociclib-Induced Cellular Senescence Is Modulated by the mTOR Complex 1 and Autophagy Rebolledo-Mira, Danitza; Herrada, Andres A. Article ISI INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2023)
Lymph Leakage Promotes Immunosuppression by Enhancing Anti-Inflammatory Macrophage Polarization Herrada, Andres A.; Riadi, Gonzalo; Escobedo, Noelia Article ISI FRONTIERS IN IMMUNOLOGY (2022)
The meningeal lymphatic vasculature in neuroinflammation Jose Herrada, Maria; Herrada, Andres A.; Escobedo, Noelia Article ISI FASEB JOURNAL (2022)
Adipose tissue macrophages as a therapeutic target in obesity-associated diseases Herrada, Andres A.; Liu, Chaohong; Escobedo, Noelia Article ISI OBESITY REVIEWS (2021)
Reduced Naïve T Cell Numbers Correlate with Increased Low-Grade Systemic Inflammation During Ageing and Can be Modulated by Physical Activity Leandra Norambuena-Mardones; Vicente Rojas-Ramos; Javiera C Moraga; Escobedo, Noelia; Herrada, AA Article SCIELO International Journal of Morphology (2021)
SARS-CoV-2 infection causes immunodeficiency in recovered patients by downregulating CD19 expression in B cells via enhancing B-cell metabolism Jing, Yukai; Luo, Li; Zhou, Peng; Xu, Zhiping; Herrada, Andres A.; Park, Chan-Sik; Kubo, Masato; Mei, Heng; Hu, Yu; Lee, Pamela Pui-Wah; et al. Article ISI SIGNAL TRANSDUCTION AND TARGETED THERAPY (2021)
DOCK2 couples with LEF-1 to regulate B cell metabolism and memory response Yang, Lu; Wang, Wenjie; Ying, Wenjing; Lin Li; Chang, Jiang; Kang, Danqing; Jiang, Panpan; Liu, Ju; Chen, Qiuyue; Herrada, Andres A.; et al. Article ISI BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2020)
Development of New Serum Biomarkers for Early Lymphedema Detection Herrada, Andres A.; Mejias, Camila; Lazo-Amador, Rodrigo; Olate-Briones, Alexandra; Lara, Danitza; Escobedo, Noelia Article ISI LYMPHATIC RESEARCH AND BIOLOGY (2019)
Innate Immune Cells' Contribution to Systemic Lupus Erythematosus Herrada, Andres A.; Escobedo, Noelia; Iruretagoyena, Mirentxu; Valenzuela, Rodrigo A.; Burgos, Paula, I; Llanos, Carolina Article ISI SCOPUS FRONTIERS IN IMMUNOLOGY (2019)
Innate Immune Cells' Contribution to Systemic Lupus Erythematosus. Herrada, Andrés A; Escobedo, Noelia; Iruretagoyena, Mirentxu; Valenzuela, Rodrigo A; Burgos, Paula I; Cuitino, Loreto; Llanos, Carolina Article Frontiers in immunology (2019)
Metabolic heterogeneity underlies reciprocal fates of T17 cell stemness and plasticity. Karmaus, Peer W F; Chen, Xiang; Lim, Seon Ah; Herrada, Andrés A; Nguyen, Thanh-Long M; Xu, Beisi; Dhungana, Yogesh; Rankin, Sherri; Chen, Wenan; Rosencrance, Celeste; Yang, Kai; Fan, Yiping; Cheng, Yong; Easton, John; Neale, Geoffrey; Vogel, Peter; Chi, Hongbo Article Nature (2019)
TASK-3 Gene Knockdown Dampens Invasion and Migration and Promotes Apoptosis in KATO III and MKN-45 Human Gastric Adenocarcinoma Cell Lines Cikutovic-Molina, Rocio; Herrada, Andres A.; Brown, Nelson Article ISI SCOPUS INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)
A filamentous bacteriophage targeted to carcinoembryonic antigen induces tumor regression in mouse models of colorectal cancer. Murgas, Paola; Bustamante, Nicolás; Araya, Nicole; Cruz-Gómez, Sebastián; Durán, Eduardo; Gaete, Diana; Oyarce, César; López, Ernesto; Herrada, Andrés Alonso; Ferreira, Nicolás; Pieringer, Hans; Lladser, Alvaro Article Cancer immunology, immunotherapy => CII (2018)
Critical roles of mTORC1 signaling and metabolic reprogramming for M-CSF-mediated myelopoiesis. Karmaus, Peer W F; Herrada, Andrés A; Guy, Cliff; Neale, Geoffrey; Dhungana, Yogesh; Long, Lingyun; Vogel, Peter; Avila, Julian; Clish, Clary B; Chi, Hongbo Article The Journal of experimental medicine (2017)
Disease Prevention=> An Opportunity to Expand Edible Plant-Based Vaccines? Concha C, Cañas R; Macuer J, Torres MJ; Herrada AA, Jamett F Article Vaccines (Basel) (2017)
Disease Prevention=> An Opportunity to Expand Edible Plant-Based Vaccines? Concha, Christopher; Cañas, Raúl; Macuer, Johan; Torres, María José; Herrada, Andrés A; Jamett, Fabiola; Ibáñez, Cristian Article Vaccines (2017)
Spironolactone Decreases DOCA-Salt-Induced Organ Damage by Blocking the Activation of T Helper 17 and the Downregulation of Regulatory T Lymphocytes Amador, Cristian A; Barrientos, Victor; Peña, Juan; Herrada, Andres A.; Gonzalez, Magdalena; Valdes, Solange; Carrasco, Loreto; Alzamora, Rodrigo; Figueroa, Fernando; Kalergis, Alexis M; et al. Article ISI SCOPUS HYPERTENSION (2014)
Spironolactone Decreases DOCA-Salt-Induced Organ Damage by Blocking the Activation of T Helper 17 and the Downregulation of Regulatory T Lymphocytes Amador, Cristian A.; Barrientos, Victor; Pena, Juan; Herrada, Andres A.; Gonzalez, Magdalena; Valdes, Solange; Carrasco, Loreto; Alzamora, Rodrigo; Figueroa, Fernando; Kalergis, Alexis M.; Michea, Luis Article Hypertension (2014)
Haem oxygenase 1 expression is altered in monocytes from patients with systemic lupus erythematosus Llanos, C.; Carreño L.J.; Henriquez, C; Gutiérrez M.A.; Anegon, I; Kalergis, A.M. Article ISI SCOPUS Immunology (2012)
Haem oxygenase 1 expression is altered in monocytes from patients with systemic lupus erythematosus Herrada A.A.; Llanos, C; Mackern-Oberti J.P.; Carreno L.J.; Henriquez, C; Gómez R.S.; Gutierrez M.A.; Anegon, I; Jacobelli S.H.; Kalergis A. M. Article Immunology (2012)
Harnessing DNA-induced immune responses for improving cancer vaccines. Herrada, Andrés A; Rojas-Colonelli, Nicole; González-Figueroa, Paula; Roco, Jonathan; Oyarce, César; Ligtenberg, Maarten A; Lladser, Alvaro Article Human vaccines & immunotherapeutics (2012)
Stimulation of Dopamine Receptor D5 Expressed on Dendritic Cells Potentiates Th17-Mediated Immunity Prado C; Contreras, F; GONZALEZ, H; Díaz P; Elgueta, D; Barrientos M.; Lladser, A; Bernales S.; Pacheco R. Article ISI SCOPUS JOURNAL OF IMMUNOLOGY (2012)
Stimulation of dopamine receptor D5 expressed on dendritic cells potentiates Th17-mediated immunity. Prado, Carolina; Contreras, Francisco; González, Hugo; Díaz, Pablo; Elgueta, Daniela; Barrientos, Magaly; Herrada, Andrés A; Lladser, Álvaro; Bernales, Sebastián; Pacheco, Rodrigo Article Journal of immunology (Baltimore, Md. : 1950) (2012)
Aldosterone as a modulator of immunity. Implications in the organ damage Herrada AA, Campino C; Amador C.A, Michea L.F; Fardella C.E, and Kalergis. A.M Article The Journal of Hypertension (2011)
Aldosterone Promotes Autoimmune Damage by Enhancing Th17-Mediated Immunity Herrada, AA; Contreras, FJ; Marini, NP; Amador, CA; Gonzalez, PA; Cortes, CM; Riedel, CA; Carvajal, CA; Figueroa F; Michea, LF; Fardella CE; Kalergis, AM Article JOURNAL OF IMMUNOLOGY (2010)
Modulation of nuclear factor-kappa B activity can influence the susceptibility to systemic lupus erythematosus Kalergis, AM; Iruretagoyena, MI; Barrientos MJ; Gonzalez, PA; Herrada, AA; Leiva, ED; Gutierrez MA; Riedel, CA; Bueno, SM; Jacobelli, SH Article Immunology (2009)
Primary aldosteronism can alter peripheral levels of transforming growth factor beta and tumor necrosis factor alpha Carvajal, CA; Herrada, AA; Castillo, CR; Contreras, FJ; Stehr, CB; Mosso, LM; Kalergis, AM; Fardella CE Article JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION (2009)
Primary aldosteronism can alter peripheral levels of transforming growth factor beta and tumor necrosis factor alpha. Carvajal, C A; Herrada, A A; Castillo, C R; Contreras, F J; Stehr, C B; Mosso, L M; Kalergis, A M; Fardella, C E Article Journal of endocrinological investigation (2009)
Immune complex-induced enhancement of bacterial antigen presentation requires Fc gamma Receptor III expression on dendritic cells Herrada, AA; Contreras, FJ; Tobar, JA; Pacheco R.; Kalergis, AM Article Proceedings of the National Academy of Sciences of the United States of America (2007)
Immune complex-induced enhancement of bacterial antigen presentation requires Fcgamma receptor III expression on dendritic cells. Herrada, Andrés A; Contreras, Francisco J; Tobar, Jaime A; Pacheco, Rodrigo; Kalergis, Alexis M Article Proceedings of the National Academy of Sciences of the United States of America (2007)
Molecular mechanisms used by Salmonella to interfere with Dendritic Cell function Bueno S, Herrada AA and Kalergis A.M. Article INMUNOLOGIA (2005)


Heme oxygenase-1 expression were decreased in monocytes from Systemic Lupus Erithematosus patients Mackern, J; Llanos, C.; Herrada, A; Leandro, C; Gomez, R; Anegon, I; Jacobelli, S.; Kalergis, A Abstract ISI JOURNAL OF IMMUNOLOGY (2012)


Estudio intervencional, aleatorizado, controlado y simple ciego para evaluar efectividad de Yerba Mate como nutracéutico complementario a tratamiento de primera línea en pacientes con EMRR en el control inflamatorio clínico y subclínico de la enfermedad Escobedo N; Lorna Galleguillos Goiry; Herrada, AA; PRADO, CAROLINA ELIZABETH Proyecto (2023)
Role of meningeal lymphatic endothelial cell-secreted Reelin in the modulation of meningeal macrophage polarization and neuroinflammation during sialidosis Noelia Escobedo Proyecto (2023)
Role of lysosomal sialidase Neu1 in meningeal lymphatic vasculature dysfunction and neuroinflammation Escobedo N; Herrada, AA Proyecto (2020)
Evaluación de poblaciones de linfocitos T vírgenes y citoquinas proinflamatorias en sangre de poblaciones de adultos mayores autovalentes o dependientes de la Región del Maule Universidad Autónoma de Chile (UA-EN2018-20) Proyecto 2019-2020 Inv. Principal
Role of lymphatic vasculature in the development of brain and kidney damage during Systemic Lupus Erythematosus Herrada, AA Proyecto (2019)
Role of Lymphatic Vasculature in the development of Multiple Sclerosis National Multiple Sclerosis Society (PP-1805-30965) Proyecto 2018-2019 Inv. Responsable
Validación de biomarcadores para la generación de un test de detección temprana de linfedema primario y secundario Universidad Autónoma de Chile (UA17-04) Proyecto 2018-2019 Coinvestigador(a)
International collaboration Chile-Mayo Clinic for genetic evaluation of naive T cells from chilean and american SLE patients and controls PCI (REDI170651) Proyecto 2017-2019 Inv. Responsable
The MKP-1/p38 axis=> coordinating innate and adaptive immunity National National Institute of Health (R01NS064599) Proyecto 2015-2017 Postdoctorado
Role of NRP-1 expressed on Tregs in the Onset and Development of Diabetes PEW (PEW-FELLOW2013) Proyecto 2013-2015 Inv. Principal
Modulation of dendritic cell function by HO-1 and MR=> implications on autoimmune and cardiovascular disease PFCHA (AT24100215) Proyecto 2009-2010 Inv. Responsable
Estudio de la expression y regulación diferencial de los receptores Fcgamma activadores e inhibidores en la célula dendrítica en lupus erimatoso sistémico=> impacto en la activación de linfocitos autorreactivos FONDECYT (1085281) Proyecto 2008-2011 Tesista
Millennium institute of Immunology and Immunotherapy Ministerio de economía, fomento y turismo (P09-016-F) Proyecto 2007-2010 Tesista
MODULATION OF DENDRITIC CELL FUNCTION BY HO-1 AND MR=> IMPLICATIONS ON AUTOIMMUNE AND CARDIOVASCULAR DISEASE PFCHA (21070429) Proyecto 2007-2010 Inv. Responsable
Novel Therapeutic and Prophylactic Strategies to Control Mucosal Infections by South American bacterial strains European union (INCO-2006-CT-032296) Proyecto 2006-2008 Tesista
Estudio de las interacciones moleculares necesarias para la sinapsis inmunológica entre la célula dendrítica y el linfocito Y=> implicaciones en la inmunidad anti-bacteriana FONDECYT (1030557) Proyecto 2005-2008 Tesista
Generacion de una vacuna recombinante contra el virus respiratorio sincicial FONDEF (D04I1075) Proyecto 2005-2007 Tesista


The role of regulatory T cells and follicular T helper cells in HBV infection Lin, Nengqi; Byazrova, Maria G.; Herrada, Andres A.; Benlagha, Kamel; Lee, Pamela; Guan, Fei; Lei, Jiahui; Yan, Youqing; Filatov, Alexander Review ISI FRONTIERS IN IMMUNOLOGY (2023)
The regulation of DOCK family proteins on T and B cells Chen, Yuanyuan; Yin, Wei; Han, Hong; Li, Jianrong; Herrada, Andres A. Review ISI JOURNAL OF LEUKOCYTE BIOLOGY (2021)
The role of ubiquitinase in B cell development and function Zhang, Tong; Sun, Jianxuan; Cheng, Jiali; Li, Jingwen; Herrada, Andres A.; Gu, Heng; Song, Hongmei Review ISI JOURNAL OF LEUKOCYTE BIOLOGY (2021)
Molecular mechanisms used by Salmonella to interfere with dendritic cell function Bueno, S. M.; Kalergis, A.M. Review SCOPUS Inmunologia (2005)

Alvaro Lladser

Professor, Principal Investigator

FUNDACIÓN CIENCIA PARA LA VIDA

Santiago, Chile

Armando Rojas

Profesor Titular, Director de Laboratorio Investigaciones Biomédicas

Ciencias Preclínicas

FACULTAD DE MEDICINA, UNIVERSIDAD CATOLICA DEL MAULE

Talca, Chile

Fernando Figueroa

Director

Medicina

UNIVERSIDAD DE LOS ANDES

Santiago de Chile, Chile

Alexis Kalergis

Full Professor

Microbiología

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE. FACULTAD DE CIENCIAS BIOLÓGICAS

Santiago, Chile

Susan Bueno

Profesor Asociado

Genética Molecular y Microbiología

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

Santiago, Chile

Leandro Carreño

Profesor Asistente

Instituto de Ciencias Biomédicas

Universidad de Chile

Santiago, Chile

Rodrigo Pacheco

Associate Investigator; Head of the Laboratory of Neuroimmunology

Fundación Ciencia para la Vida

Santiago, Chile

Sebastian Bernales

Founder

Merken Biotech

Santiago, Chile

Wendy Gonzalez

Director of the Center for Bioinformatics, Simulations and Modeling (CBSM)

Bioinformática

CENTRO DE BIOINFORMÁTICA Y SIMULACIÓN MOLECULAR (CBSM)/ UNIVERSIDAD DE TALCA

Talca, Chile

Nelson Brown

Associate Professor

University of Talca

Talca, Chile

Carolina Llanos

Associate Professor

Pontificia Universidad Católica de Chile

Santiago, Chile

Luis Michea

PROFESOR ASOCIADO

PROGRAMA FISIOLOGIA Y BIOFISICA

UNIVERSIDAD DE CHILE

Santiago, Chile

Rodrigo Alzamora

ASSISTANT PROFESSOR

INSTITUTE OF BIOMEDICAL SCIENCES

UNIVERSIDAD DE CHILE

Santiago, Chile

Leandro Zuñiga

Profesor Asociado

Medicine

Universidad de Talca

Talca, Chile

Patricia Diaz

Academic

University of Connecticut Health Center

Farmington, CT, Estados Unidos

Carolina Prado

Investigador Joven

Fundacion Ciencia y Vida

Santiago, Chile

Cristián Amador

Profesor Asistente

Universidad San Sebastián

Santiago, Chile

Pablo Díaz

Professional/Scientific advisor

Scientific Affairs

Instituto de Salud Públida de Chile

santiago, Chile

Rodrigo Valenzuela

Postdoctorado

Oftalmología

Universidad de Chile

Santiago, Chile

Loreto Cuitiño

Investigador Asociado

Oftalmología

Hospital Clínico Universidad de Chile

229788866, Chile

Andres Herrada

Principal Investigator

Instituto de Ciencias Biomédicas

Universidad Autónoma de Chile

Talca, Chile

Noelia Escobedo

Profesor Asistente

Facultad de Ciencias de la Salud

Universidad Autónoma de Chile

Talca, Chile

Francisco Contreras

Investigador en área de Investigación y Desarrollo de productos biológicos

Centrovet Ltda.

Santiago, Chile

Juan Peña

Director Medico

Servicios Veterinarios especializados VETCO

santiago, Chile

Alexandra Olate

Mirentxu Iruretagoyena

Jefe Seccion Inmunologia

Laboratorio Clinico

Clinica Alemana de Santiago

Santiago, Chile

Emilia Escalona

Investigador postdoctoral

Universidad Autónoma de Chile

Talca , Chile

Gonzalo Riadi

Assistant Professor

Bioinformatics

Universidad de Talca

Talca, Chile

HUGO GONZALEZ

Associate Professor

Fundación Ciencia y Vida

Santiago, Chile

Angel Cayo

ACADÉMICO INVESTIGADOR

MEDICINA TRASLACIONAL

Universidad Católica del Maule

TALCA, Chile

Andres Alonso Herrada Hidalgo

Líneas de Investigación

Educación

Bioquimico, PONTIFICIA UNIVERSIDAD CATOLICA DE VALPARAISO. Chile, 2007

Doctor en Ciencias Biologicas Mencion Genetica Molecular y Microbiologia, PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE. Chile, 2011

Magister en Ciencias Biológicas, PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE. Chile, 2008

Experiencia Académica

Postdoctoral fellow Full Time

Profesor asistente Full Time

Miembro del claustro académico del Doctorado en Ciencias Biomédicas Full Time

Miembro del claustro académico del Doctorado en Ciencias Biomédicas Other

Experiencia Profesional

Postdoctoral training

Postdoctoral Fellow Full Time

Article (31)

Abstract (1)

Proyecto (17)

Evaluación de poblaciones de linfocitos T vírgenes y citoquinas proinflamatorias en sangre de poblaciones de adultos mayores autovalentes o dependientes de la Región del Maule

Role of Lymphatic Vasculature in the development of Multiple Sclerosis

Validación de biomarcadores para la generación de un test de detección temprana de linfedema primario y secundario

International collaboration Chile-Mayo Clinic for genetic evaluation of naive T cells from chilean and american SLE patients and controls

The MKP-1/p38 axis=> coordinating innate and adaptive immunity National

Role of NRP-1 expressed on Tregs in the Onset and Development of Diabetes

Modulation of dendritic cell function by HO-1 and MR=> implications on autoimmune and cardiovascular disease

Estudio de la expression y regulación diferencial de los receptores Fcgamma activadores e inhibidores en la célula dendrítica en lupus erimatoso sistémico=> impacto en la activación de linfocitos autorreactivos

Millennium institute of Immunology and Immunotherapy

MODULATION OF DENDRITIC CELL FUNCTION BY HO-1 AND MR=> IMPLICATIONS ON AUTOIMMUNE AND CARDIOVASCULAR DISEASE

Novel Therapeutic and Prophylactic Strategies to Control Mucosal Infections by South American bacterial strains

Estudio de las interacciones moleculares necesarias para la sinapsis inmunológica entre la célula dendrítica y el linfocito Y=> implicaciones en la inmunidad anti-bacteriana

Generacion de una vacuna recombinante contra el virus respiratorio sincicial

Review (4)