Man

Rodrigo Ricardo Alzamora Miranda

ASSISTANT PROFESSOR

UNIVERSIDAD DE CHILE

Santiago, Chile

Líneas de Investigación


Regulation of renal epithelial ion transport by protein kinases. Physiopathological mechanisms of arterial hypertension. Physiopathological mechanisms of chronic kidney disease.

Educación

  •  Biochemistry, Universidad de Chile. Chile, 2000
  •  Biochemist, Universidad de Chile. Chile, 2000
  •  Physiology, ROYAL COLLEGE OF SURGEONS IN IRELAND. Irlanda, 2007

Experiencia Académica

  •   ASSISTANT PROFESSOR Full Time

    Universidad de Chile

    MEDICINE

    Santiago, Chile

    2014 - A la fecha

  •   POSTDOCTORAL FELLOW Full Time

    UNIVERSIDAD DE CHILE

    MEDICINE

    Santiago, Chile

    2013 - 2014

  •   POSTDOCTORAL FELLOW Full Time

    UNIVERSITY OF PITTSBURGH

    MEDICINE

    Pittsburgh, Estados Unidos

    2007 - 2012

  •   POSTDOCTORAL FELLOW Full Time

    ROYAL COLLEGE OF SURGEONS IN IRELAND

    MEDICINE

    Dublin, Irlanda

    2006 - 2007

Experiencia Profesional

  •   RESEARCH ASSISTANT Full Time

    UNIVERSITY COLLEGE CORK

    Cork, Irlanda

    2000 - 2001

Formación de Capital Humano


SUPERVISION OF RESEARCH UNITS
2008 Summer medical student Miss Rula Kanj. “Role of AMPK in metabolic stress-induced ENaC inhibition in kidney cells”.
2007 Supervisor Transition Year Programme
2005 Summer student Miss Laura Brown. “An investigation into the localization of the binding sites of 17?-estradiol within the PKC-? isozyme”.
2002 Summer student Mr. Shane Harrington. “Rapid anti-secretory effect of 17?-estradiol on rat distal colon”.


Premios y Distinciones

  •   Sheppard Prize

    ROYAL COLLEGE OF SURGEONS IN IRELAND

    Irlanda, 2003

    Prize for best poster at the Royal College of Surgeons in Ireland Research Day

  •   Sheppard Prize

    ROYAL COLLEGE OF SURGEONS IN IRELAND

    Chile, 2006

    Best poster presentation at the Royal College of Surgeons in Ireland Research Day.

  •   Best Postgraduate Poster FASEB Summer Conference

    FASEB

    Estados Unidos, 2006

    Best Postgraduate Poster at the FASEB Summer Conference, Tucson AZ, USA

  •   Best Oral Communication DMMC

    DUBLIN MOLECULAR MEDICINE CENTRE

    Irlanda, 2006

    Best Oral Communication at the Dublin Molecular Medicine Centre Research Day


 

Article (25)

Mineralocorticoids modulate the expression of the-3 subunit of the Na+, K+-ATPase in the renal collecting duct
Aurora kinase A activates the vacuolar H + -ATPase (V-ATPase) in kidney carcinoma cells
Angiotensin-(1-9) reverses experimental hypertension and cardiovascular damage by inhibition of the angiotensin converting enzyme/Ang II axis
Spironolactone Decreases DOCA-Salt-Induced Organ Damage by Blocking the Activation of T Helper 17 and the Downregulation of Regulatory T Lymphocytes
AMP-activated protein kinase regulates the vacuolar H+-ATPase via direct phosphorylation of the A subunit (ATP6V1A) in the kidney
Resveratrol inhibits the epithelial sodium channel via phopshoinositides and AMP-activated protein kinase in kidney collecting duct cells.
Berberine Reduces cAMP-Induced Chloride Secretion in T84 Human Colonic Carcinoma Cells through Inhibition of Basolateral KCNQ1 Channels.
Estrogen inhibits chloride secretion caused by cholera and Escherichia coli enterotoxins in female rat distal colon.
Sexual dimorphism and oestrogen regulation of KCNE3 expression modulates the functional properties of KCNQ1 K+ channels
AMP-activated protein kinase inhibits KCNQ1 channels through regulation of the ubiquitin ligase Nedd4-2 in renal epithelial cells
PKA regulates vacuolar H+-ATPase localization and activity via direct phosphorylation of the a subunit in kidney cells.
Regulation of the creatine transporter by AMP-activated protein kinase in kidney epithelial cells.
SGLT1, a novel cardiac glucose transporter, mediates increased glucose uptake in PRKAG2 cardiomyopathy
Vacuolar H+-ATPase apical accumulation in kidney intercalated cells is regulated by PKA and AMP-activated protein kinase.
AMP-activated protein kinase inhibits alkaline pH- and PKA-induced apical vacuolar H+-ATPase accumulation in epididymal clear cells
Functional Regulation of the Epithelial Na+ Channel by I kappa B Kinase-beta Occurs via Phosphorylation of the Ubiquitin Ligase Nedd4-2
Genomic Priming of the Antisecretory Response to Estrogen in Rat Distal Colon throughout the Estrous Cycle
Direct binding and activation of protein kinase C isoforms by steroid hormones.
Rapid responses to aldosterone in the kidney and colon.
Direct binding and activation of protein kinase C isoforms by aldosterone and 17beta-estradiol.
Female gender-specific inhibition of KCNQ1 channels and chloride secretion by 17beta-estradiol in rat distal colonic crypts.
Nongenomic effect of aldosterone on Na+,K+-adenosine triphosphatase in arterial vessels
Non-genomic convergent and divergent signalling of rapid responses to aldosterone and estradiol in mammalian colon.
Rapid responses to steroid hormones: from frog skin to human colon. A homage to Hans Ussing.
Role of 11beta-hydroxysteroid dehydrogenase in nongenomic aldosterone effects in human arteries.

BookSection (1)

CFTR Regulation by Phosphorylation.

Proyecto (5)

Molecular determinants and physiological role of steroid hormone-induced PKC activation in distal colon.
Dietary chloride in the development of hypertension: a new player regulating intrarenal renin-angiotensin system and dendritic cell activity?
Regulation of Ion Channels by AMP-Activated Kinase in Kidney Cells
Regulation of renal tubular sodium reabsorption by AMP-activated protein kinase in angiotensin II-induced hypertension
Role in sodium homeostasis and hypertension of a novel molecular mechanism that mediates the action of aldosterone in target tissues: regulation of the beta-3 subunit of the sodium pump
31
Rodrigo Alzamora

ASSISTANT PROFESSOR

INSTITUTE OF BIOMEDICAL SCIENCES

UNIVERSIDAD DE CHILE

Santiago, Chile

4
Luis Michea

PROFESOR ASOCIADO

PROGRAMA FISIOLOGIA Y BIOFISICA

UNIVERSIDAD DE CHILE

Santiago, Chile

1
Luis Cid

Principal Research

Laboratorio Biología Molecular

CENTRO DE ESTUDIOS CIENTIFICOS CECs

Valdivia, Chile

1
Juan Peña

Director Medico

Servicios Veterinarios especializados VETCO

santiago, Chile

1
Pablo Díaz

Professional/Scientific advisor

Scientific Affairs

Instituto de Salud Públida de Chile

santiago, Chile

1
Cristián Amador

Profesor Asistente

Instituto de Ciencias Biomédicas

UNIVERSIDAD AUTONOMA DE CHILE

Santiago, Chile

1
Francisco Sepúlveda

Research

Laboratorio Biología Molecular

CENTRO DE ESTUDIOS CIENTÍFICOS (CECS)

Valdivia, Chile

1
Pablo León

Asistente de Investigación

Ciencias Biomedicas

Universidad de Chile

Santiago, Chile

1
Alexis Gonzalez

Adjunct Professor

Instituto de Química

Pontificia Universidad Católica de Valparaiso

Valparaíso, Chile

1
daniel hevia

Investigador PhD

Inmunologia

Universidad de Chile

santiago, Chile

1
Maria Ocaranza

Asociate Professor

Cardiovascular Diseases Division

Pontificia Universidad Catolica de Chile

Santiago, Chile

1
Alexis Kalergis

Full Professor

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE. FACULTAD DE CIENCIAS BIOLÓGICAS

Santiago, Chile

1
Fernando Figueroa

Director

Medicina

UNIVERSIDAD DE LOS ANDES

Santiago de Chile, Chile

1
Mario Chiong

Profesor

Departamento de Bioquímica y Biología Molecular

Universidad de Chile

Santiago, Chile

1
Pedro Ayala

Profesor investigador asistente

Departamento de Enfermedades Respiratorias

Pontificia Universidad Católica de Chile

Santiago, Chile

1
Viviana Bustos

Researcher

Universidad de Los Lagos

Valdivia, Chile