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Alexis Antonio Gonzalez Parra

Adjunct Professor

Pontificia Universidad Católica de Valparaiso

Valparaíso, Chile

Líneas de Investigación


Mechanisms of collecting duct renin regulation and interactions with prorenin receptor. Intrarenal renin angiotensin system in kidney disease and hypertension

Educación

  •  Physiology, PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE. Chile, 2008
  •  Biological Sciences, PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE. Chile, 2007
  •  Biology, PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE. Chile, 2001

Experiencia Académica

  •   Adjunct Professor Full Time

    PONTIFICIA UNIVERSIDAD CATOLICA DE VALPARAISO

    Sciences

    Valparaíso, Chile

    2012 - A la fecha

Experiencia Profesional

  •   Postdoctoral Full Time

    Tulane University

    New Orleans, Estados Unidos

    2009 - 2012

Formación de Capital Humano


Undergraduate Thesis:

1. Regulation of collecting duct renin by vasopressin. Flavia Cifuentes, Bioquímico PUCV 2012-2015
2. Effect of the activation of the prorenin receptor on profibrotic markers and reactive oxygen species. Leonardo Zamora, Bioquímico PUCV 2014-2015
3. Effect of a high potassium diet on the expression of intrarrenal renin angiotensin system in hypertensive rats Matías Gallardo, Bioquímico PUCV 2015-2015, Co-tutoring Dr. Carlos P Vio, Pontificia Universidad Católica de Chile
4. Angiotensin II stimulated renin expression in collecting duct cells via PKC and calcium. Cristobal Ibaceta, Bioquímico PUCV 2014-2015
5. Role of the E prostanoid receptors in the regulation of collecting duct renin” Nicolas Salinas, Bioquímico PUCV 2015-2017
6. Angiotensin II and vasiopressin in the modulation of renin expression in the collecting duct. Alex González, Bioquímico PUCV 2015-2017.
7. Expression of the intra-renal renin angiotensin system in obstructive uropathy. Steffany Figueroa. Bioquímico PUCV 2016 (on-going), Co-tutoring Dr. Cristian Amador Universidad Autonoma de Chile
8. Expression of the ntra-renal renin angiotensin system in renal ischemya - reperfussion. Steffany Duque Bioquímico PUCV 2017 (on-going), Co-tutoring Dr. Cristian Amador Universidad Autonoma de Chile

PhD Thesis:

1. Arsenic and antimony as toxic elements for collecting duct cells (PhD in Chemical sciences, PUCV, On-going)


Difusión y Transferencia


International meetings (last three years):

1. Leonardo Zamora, Cristobal Ibaceta Flavia Cifuentes, Alexis A. Gonzalez. (Pro)renin receptor increases profibrotic gene expression via reactive oxygen species in rat renal inner medullary collecting duct cells. 1st Panamerican Congress of Physiological Sciences, Iguassu Falls Brazil, August 2-6, 2014.

2. Alexis A. Gonzalez, Flavia Cifuentes, Leonardo Zamora, Cristobal Ibaceta, Minolfa C Prieto. Vasopressin receptor 2 (V2R) increases renin expression in mouse cortical collecting duct cells. 1st Panamerican Congress of Physiological Sciences, Iguassu Falls Brazil, August 2-6, 2014.

3. Alexis A. Gonzalez, Liu Liu, Flavia Cifuentes, L. Gabriel Navar, Minolfa C Prieto. Regulation of renin expression in collecting duct cells. III international symposium of the renin angiotensin system (RAS): understanding systemic and tissue RAS. August 8th- 9th- 10th, 2014 at the Hotel/UNIFESP, São Paulo, SP, Brazil. (Invited speaker).

4. Leonardo Zamora, Cristobal Ibaceta Flavia Cifuentes, Alexis A. Gonzalez. Activación del receptor de (pro)renina aumenta la expresión de genes profibroticos vía formación de especies reactivas de oxígeno en cultivos primarios renales de células epiteliales de túbulo colector medular. XVII Congreso Sociedad Latinoamericana de Nefrología e Hipertensión (SLANH), Casa Piedra Santiago, 19 al 23 de agosto 2014.

5. Alexis A. Gonzalez, Flavia Cifuentes, Leonardo Zamora, Cristobal Ibaceta, Minolfa C Prieto. Estimulación del receptor v2 de vasopresina aumenta los niveles de renina en células de túbulo colector renal. XVII Congreso Sociedad Latinoamericana de Nefrología e Hipertensión (SLANH), Casa Piedra Santiago, 19 al 23 de agosto 2014.

6. Alexis A. Gonzalez, Flavia Cifuentes, Leonardo Zamora, Cristobal Ibaceta, Minolfa C Prieto. Vasopressin receptor 2 (V2R) increases renin expression in mouse cortical collecting duct cells. Council of High Blood Pressure Research 2014, September 9-12, San Francisco, CA, USA.

7. Alexis A. Gonzalez, Liu Liu, Lucienne S. Lara, Camille RT Bourgeois, Cristobal Ibaceta-Gonzalez, Dale M. Seth, Minolfa C. Prieto. Angiotensin II regulates renin expression in collecting duct cells through PKC/cAMP/PKA/CREB pathway. Southern Regional Meeting, February 26 - 28, 2015, New Orleans, LA, USA

8. Alexis A. Gonzalez, Flavia Cifuentes, Leonardo Zamora, Cristobal Ibaceta, Minolfa C Prieto. Vasopressin receptor 2 (V2R) increases renin expression in mouse cortical collecting duct cells. Experimental BIology 2015, March 27 – April 1, Boston, MA, USA.

9. Alexis A. Gonzalez, Intrarenal renin-angiotensin-system in hypertension: is the collecting duct renin contributing to sodium reabsorption? 1st PanAmerican Symposium at EB-2015, April 1, Boston, MA, USA. (Invited speaker).

10. Catherina A Cuevas, Alexis A Gonzalez, Nivaldo C Inestrosa, Carlos P Vio, Minolfa C Prieto. (pro) Renin Receptor Stimulates the Expression of Fibrotic Genes in Mouse Collecting Ducts Cells via Wnt/?-catenin Signaling, Independently of Angiotensin II. Experimental BIology 2015, March 27 – April 1, Boston, MA, USA.

11. V. Reverte Ribo, V.R. Gogulamudi, A.A. Gonzalez, C.B. Rosales, M.R. Gallaty, A. Castillo, A. Ichiara, L.G. Navar, M.C. Prieto. Deletion of the Prorenin Receptor in the Collecting Duct Impairs Renal Function and Attenuates Blood Pressure in Chronic Angiotensin II-Infused Mice. Experimental Biology 2016, April 2-6 San Diego USA.

12. A.A. Gonzalez, V. Reverte-Ribo, A. Katsurada, C.B. Rosales, M. Galatty, M. McLellan, O. Gentile, L.C. Veiras, D.M. Seth, A. Ichihara, A.A. Mc Donough, M. Mamenko, O.M. Pochynyuk, L.G. Navar, M.C. Prieto. Lack of the Prorenin Receptor in the Collecting Duct Blunts the ENaC Responses to Chronic Angiotensin II. Experimental Biology 2016, April 2-6 San Diego USA.

13. Alexis A. Gonzalez. Hormonal Regulation of collecting duct-derived renin. IV INTERNATIONAL SYMPOSIUM OF THE RENIN ANGIOTENSIN SYSTEM (RAS): From cell biology to novel physiological paradigms and the latest advances in therapeutics” and Meeting of Brazilian Society of Hypertension. July 19-23 2016, São Paulo, Brasil. (Invited speaker).

14. Alexis A Gonzalez, Cristian Reyes-Martinez, Leonardo Zamora, Minolfa C Prieto. Prorenin Receptor Activation Increases Profibrotic Markers and Fibroblast-like Phenotype Through MAPK-dependent ROS Formation In Mouse Renal Collecting Duct Cells. Council of the American Heart Association, sept 13-16 2016, Orlando Florida.

Diffusion talks in schools and Universities:

1. Chemistry in action “Reforestando el Belloto del Norte (Beilschmiedia Miersii) en la comuna de Quilpué”. Quilpué, Chile

2. Explora: “Que es la hipertensión arterial?” Liceo Matilde Brandau de Ross A-25 de Valparaíso, octubre de 2015, Valparaíso, Chile.

3. Explora: “Que es la hipertensión” Liceo Bicentenario de Viña del Mar en octubre de 2014, Valparaíso, Chile.

4. Samsung – PUCV “soluciones para el futuro” 2014, Valparaíso, Chile.

5. “What we have learned about renin and the (pro)renin receptor in the collecting duct” Seminars at the Department of Physiology, Tulane Medical Center, New Orleans USA. November 11, 2013.

6. "Renin, (Pro)renin Receptor and Cyclooxygenase-2: a dynamic trio in the renal medulla for blood pressure regulation?" Seminars at the Department of Physiology, Tulane Medical Center, New Orleans USA. February 23, 2015.

7. Explora: “Que es la hipertensión arterial?” Colegio Guardiamarina Riquelme October 3, 2016, Valparaíso, Chile.


Premios y Distinciones

  •   “Southern Society for Clinical Investigation (SSCI) Trainee Research Award”

    Southern Section-American Federation for Medical Research (SAFMR)

    Estados Unidos, 2011

    Given for the best work in basic research

  •   Young investigator award

    Council of High Blood Pressure Research

    Chile, 2012

    Given by the Council on Kidney in Cardiovascular Disease, Council of High Blood Pressure Research, Washington, DC, Estados Unidos to recognize the Young Investigator research.

  •   “Premio Investigador Joven”

    sociedades de Nefrología, Hipertensión y Transplante,

    Chile, 2012

    Given to the best basic work research in kidney and recognizing young investigator

  •   “American Heart Association (AHA) International Mentoring Travel Grant”

    American Heart Association

    Estados Unidos, 2013

    Mentoring travel grant, to have the opportunity to talk and share new findings with previous mentors.

  •   “SAFMR/SSCI Junior Faculty Research Travel Award”

    Southern Section-American Federation for Medical Research (SAFMR) and the Southern Society for Clinical Investigation (SSCI)

    Chile, 2015

    Given to the young reseachers out of EEUU recognizing as Faculties.

  •   “Early Career Physiologist Award”

    American Physiological Society

    Chile, 2015

    Given to the early career investigator from US and around the world.

  •   Mejor trabajo científico

    Sociedad Chilena de Hipertensión Arterial

    Chile, 2016

    mejor trabajo ciencia basica area hipertensión

  •   Mejor trabajo científico

    Sociedad Chilena de Nefrología

    Chile, 2016

    Mejor trabajo ciencia básica

  •   Interamerican Society of Hypertension- Best Basic Research

    Interamerican Society of Hypertension

    Argentina, 2017

    IASH-SAHA joint Meeting, Mendoza Argentina

  •   “Travel Award” American Physiological Society PANAMERICAN CONGRESS OF PHYSIOLOGY, La Havana, Cuba.

    American Physiological Society (PANAM)

    Cuba, 2019

    Travel Award Panamerican Congress Physiology without borders

  •   “Paul Dudley White International Shoolar American Heart Association (AHA)” Hypertension research, New Orleans 2019.

    American Heart Association

    Estados Unidos, 2019

    “Paul Dudley White International Shoolar American Heart Association (AHA)” Hypertension research, New Orleans 2019.


 

Article (44)

alpha-Ketoglutarate Upregulates Collecting Duct (Pro)renin Receptor Expression, Tubular Angiotensin II Formation, and Na+ Reabsorption During High Glucose Conditions
Association of Cardiotoxicity With Doxorubicin and Trastuzumab: A Double-Edged Sword in Chemotherapy
High glucose induces trafficking of prorenin receptor and stimulates profibrotic factors in the collecting duct
The evolving complexity of the collecting duct renin-angiotensin system in hypertension
Antimony(III) induces fibroblast-like phenotype, profibrotic factors and reactive oxygen species in mouse renal cells
Augmented transcripts of kidney injury markers and renin angiotensin system in urine samples of overweight young adults
Low Nitric Oxide Bioavailability Increases Renin Production in the Collecting Duct
MicroRNAs and obesity-induced endothelial dysfunction: key paradigms in molecular therapy
(Pro) renin Receptor-Dependent Induction of Profibrotic Factors Is Mediated by COX-2/EP4/NOX-4/Smad Pathway in Collecting Duct Cells
Potassium Intake Prevents the Induction of the Renin-Angiotensin System and Increases Medullary ACE2 and COX-2 in the Kidneys of Angiotensin II-Dependent Hypertensive Rats
Upregulation of Cortical Renin and Downregulation of Medullary (Pro)Renin Receptor in Unilateral Ureteral Obstruction
Myeloid CD11c(+) Antigen-Presenting Cells Ablation Prevents Hypertension in Response to Angiotensin II Plus High-Salt Diet
The prorenin receptor in the cardiovascular system and beyond
(Pro)renin receptor activation increases profibrotic markers and fibroblast-like phenotype through MAPK-dependent ROS formation in mouse renal collecting duct cells
Collecting duct prorenin receptor knockout reduces renal function, increases sodium excretion, and mitigates renal responses in ANG II-induced hypertensive mice
Mineralocorticoids modulate the expression of the-3 subunit of the Na+, K+-ATPase in the renal collecting duct
PGE2 upregulates renin through E-prostanoid receptor 1 via PKC/cAMP/CREB pathway in M-1 cells
Prostaglandin E2 Induces Prorenin-Dependent Activation of (Pro)renin Receptor and Upregulation of Cyclooxygenase-2 in Collecting Duct Cells.
Role of Collecting Duct Renin in the Pathogenesis of Hypertension
IMPLEMENTATION OF AN ANALYTICAL METHOD FOR THE DETERMINATION OF INORGANIC ARSENIC SPECIES IN OCCUPATIONALLY EXPOSED HUMAN URINE SAMPLES AND ITS TOXIC EFFECTS ON EPITHELIAL CELLS OF RENAL COLLECTING TUBULE
Vasopressin/V2 receptor stimulates renin synthesis in the collecting duct
Angiotensin II increases fibronectin and collagen I through the beta-catenin-dependent signaling in mouse collecting duct cells
Renin and the (pro)renin receptor in the renal collecting duct: Role in the pathogenesis of hypertension.
Angiotensin II increases the expression of (pro)renin receptor during low-salt conditions
Angiotensin II-Independent Upregulation of Cyclooxygenase-2 by Activation of the (Pro) Renin Receptor in Rat Renal Inner Medullary Cells
Evolving concepts on regulation and function of renin in distal nephron.
Cyclooxygenase-2 and hypoxia-regulated proteins are modulated by basic fibroblast growth factor in acute renal failure
The complex interplay between cyclooxygenase-2 and angiotensin II in regulating kidney function.
The sodium-activated sodium channel is expressed in the rat kidney thick ascending limb and collecting duct cells and is upregulated during high salt intake.
Vasopressin controls stanniocalcin-1 gene expression in rat and mouse kidney.
Angiotensin II Stimulates Renin in Inner Medullary Collecting Duct Cells via Protein Kinase C and Independent of Epithelial Sodium Channel and Mineralocorticoid Receptor Activity
Increased renin excretion is associated with augmented urinary angiotensin II levels in chronic angiotensin II-infused hypertensive rats.
Soluble form of the (pro)renin receptor is augmented in the collecting duct and urine of chronic angiotensin II-dependent hypertensive rats.
E Prostanoid-1 receptor regulates renal medullary ?ENaC in rats infused with angiotensin II
A Polymorphic GT Short Tandem Repeat Affecting ?-ENaC mRNA Expression Is Associated With Low Renin Essential Hypertension
Effect of ischemic acute renal damage on the expression of COX-2 and oxidative stress-related elements in rat kidney
bFGF induces an earlier expression of nephrogenic proteins after ischemic acute renal failure
Biochemical and genetic characterization of 11 beta- hydroxysteroid dehydrogenase type 2 in low-renin essential hypertensives
Congenital lipoid adrenal hyperplasia caused by a novel splicing mutation in the gene for the steroidogenic acute regulatory protein.
NOVEL INTRONIC MUTATION OF MEN1 GENE CAUSING FAMILIAL ISOLATED PRIMARY HYPERPARATHYROIDISM
ALDOSTERONISMO PRIMARIO E HIPERTENSION ARTERIAL
Primary aldosteronism and hypertensive disease
Two homozygous mutations in the 11 beta-hydroxysteroid dehydrogenase type 2 gene in a case of apparent mineralocorticoid excess
11 beta-hydroxysteroid dehydrogenase activity in patients with hypertension and low plasma renin activity

Abstract (2)

The activation of the(Pro)renin receptor (PRR) stimulates fibrotic factors expression independent of b-catenin signaling pathway in collecting duct cells
Vasopressin Type 2 Receptor (V2R) Activation Increases Renin Expression in Mouse Renal Collecting Duct Cells through cAMP/PKA/CREB Pathway

BookWhole (1)

Vasopressin actions in the kidney renin angiotensin system and its role in hypertension and renal disease

Proyecto (3)

Development of bio-analytical methods for the evaluation and visualization of the distribution and chemical reactivity of As and Sb species in renal cell systems through molecular and atomic fluorescence
Role of alpha-ketoglutarate and (pro)renin receptor in intra-renal angiotensin II formation, Na+ reabsorption and blood pressure in diabetic disease
Use of STEAM education in high education

Review (2)

Targeting Autophagy in Obesity-Associated Heart Disease
Roles of collecting duct renin and (pro)renin receptor in hypertension: Mini review
51
Alexis Gonzalez

Adjunct Professor

Instituto de Química

Pontificia Universidad Católica de Valparaiso

Valparaíso, Chile

8
Carlos Fardella

Profesor Titular

Endocrinología

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

7
Carlos Vio

Profesor

Fisiologia

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

6
Carlos Cespedes

Tecnologo Medico

Fisiologia

P. Universidad Católica de Chile

Santiago, Chile

4
Cristian Carvajal

Associate Professor

Endocrinologia

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

3
lorena mosso

profesor asociado

endocrinologia

Pontificia Universidad Catolica de Chile

santiago, Chile

2
Pilar Cárdenas

Asistente de investigación Fisiología y Bioquímica renal

Instituto de Química

Pontificia Universidad Católica de Valparaíso

Valparaiso, Chile

2
Luis Michea

PROFESOR ASOCIADO

PROGRAMA FISIOLOGIA Y BIOFISICA

UNIVERSIDAD DE CHILE

Santiago, Chile

2
Nibaldo Inestrosa

Full Professor

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

2
Leonardo Zamora

Estudiante de Doctorado en Biotecnología

Química

Universidad Técnica Federico Santa María

Valparaíso, Chile

2
Patricio Araos

Postdoctoral Researcher

Fisiología

Universidad Autónoma de Chile

Santiago, Chile

2
Waldo Quiroz

Profesor Adjunto

Pontificia Universidad Católica de Valparaíso

Valparaíso, Chile

2
Cristián Amador

Profesor Asistente

Instituto de Ciencias Biomédicas

UNIVERSIDAD AUTONOMA DE CHILE

Santiago, Chile

1
Ricardo Henriquez

Jefe de Carrera; Docente asistente

Kinesiología

Universidad Santo Tomas

Viña del Mar, Chile

1
Ioram Jacubovsky

Médico Cirujano

Servicio de Cirugía

Hospital Dr. Sótero Del Río

Santiago, Chile

1
Carolina Prado

Investigador Joven

Fundacion Ciencia y Vida

Santiago, Chile

1
Mauricio Lozano

Asistente de Investigación

Centro de Investigación e Innovación Biomédica

Universidad de Los Andes

Santiago, Chile

1
José Erpel

SUBDIRECTOR DE ESCUELA

SALUD

DUOC UC

SANTIAGO, Chile

1
Rodrigo Alzamora

ASSISTANT PROFESSOR

INSTITUTE OF BIOMEDICAL SCIENCES

UNIVERSIDAD DE CHILE

Santiago, Chile

1
Rodrigo Pacheco

Associate Investigator; Head of the Laboratory of Neuroimmunology

Fundación Ciencia para la Vida

Santiago, Chile

1
daniel hevia

Investigador PhD

Inmunologia

Universidad de Chile

santiago, Chile

1
Alvaro Huete

Jefe Departamento

Radiologia

Pontificia Universidad Católica de Chile

Santiago, Chile

1
Pablo Díaz

Professional/Scientific advisor

Scientific Affairs

Instituto de Salud Públida de Chile

santiago, Chile

1
Tomas Perez-Acle

Full Professor

Computational Biology Lab

Fundación Ciencia para la Vida

Santiago, Chile

1
Fernando Avila

Graduate Researcher / PhD Student

Cirugía y Cancer

Imperial College London

London, Reino Unido

1
Carlos Irarrazabal

Full Professor

Fisiología

Universidad de Los Andes

Santiago, Chile

1
Alexis Kalergis

Full Professor

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE. FACULTAD DE CIENCIAS BIOLÓGICAS

Santiago, Chile

1
Pablo León

Asistente de Investigación

Ciencias Biomedicas

Universidad de Chile

Santiago, Chile

1
Nicole Roldán

Estudiante Doctorado Ciencias mención Químico

Laboratorio de Química Biológica

PONTIFICIA UNIVERSIDAD CATOLICA VALPARAÍSO

Valparaíso, Chile