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Cristian Andres Carvajal Maldonado

Associate Professor

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

Líneas de Investigación


Genetic, epigenetic and molecular factors involved in endocrine hypertension; Primary aldosteronism; Non-Classic apparent mineralocorticoid excess; Extracellular vesicles and endocrine hypertension.

Educación

  •  Master in Biochemistry, PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE. Chile, 2007
  •  Doctor in Medical Sciences, PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE. Chile, 2013
  •  Biochemistry graduate, PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE. Chile, 1998
  •  Biochemist, PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE. Chile, 2000

Experiencia Académica

  •   Visiting Internship Full Time

    UNIVERSITY OF MISSISSIPPI

    Medicine

    Mississippi, Estados Unidos

    2005 - 2005

  •   Visiting Professor Full Time

    UNIVERSITA DEGLI STUDI DI VERONA

    Medicine

    Verona, Italia

    2012 - 2012

  •   Associate Professor Full Time

    PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

    Medicine

    Santiago, Chile

    2018 - A la fecha

  •   Instructor/PhD Full Time

    PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

    Medicine

    Santiago, Chile

    2008 - 2014

  •   Investigator/MS Full Time

    PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

    Medicine

    Santiago, Chile

    2003 - 2008

  •   Visiting Professor Other

    UNIVERSITY OF QUEENSLAND

    Medicine

    Brisbane, Australia

    2017 - 2017

  •   Visiting Professor Full Time

    MONASH UNIVERSITY

    Hudson Medical Research Institute

    Melbourne, AUSTRALIA, Chile

    2019 - 2019

  •   Assistant Professor Full Time

    PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

    Medicine

    Santiago, Chile

    2014 - 2018

Experiencia Profesional

  •   Assistant Professor Full Time

    Pontificia Universidad Catolica de Chile

    Santiago, Chile

    2014 - 2018

  •   Associate Professor Full Time

    Pontificia Universidad Católica de Chile

    Santiago, Chile

    2018 - A la fecha

  •   Director (Basic Sciences Branch) Full Time

    Centre of Endocrinology Translational (CETREN-UC)

    Santiago, Chile

    2019 - A la fecha

  •   Head Full Time

    Laboratory of Endocrinology UC

    Santiago, Chile

    2015 - A la fecha

Formación de Capital Humano


Number of undergraduate students: 12
Number of graduate students – Master: 2
Number of graduate students – Ph.D.: 3
Number of postdoctorates: 1

DIRECTOR/SUPERVISOR UNDERGRADUATE THESIS
1. 2020-2021. Jorge Perez-Lopez. “Uso de la tecnología de “Nanotracking Analysis (NTA)” en el estudio y caracterización de vesículas extracelulares para la sospecha, seguimiento y diagnóstico de hiperaldosteronismo primario”. Tesis de Bioquimica. Pontifica Universidad Catolica de Chile. Santiago, Chile.
2. 2020. Maria Gabriela Ugarte. “Primary aldosteronism”. Pregrado Medicina UANDES. Unidad Extramural. Pontifica Universidad Catolica de Chile. Santiago, Chile.
3. 2018-2019. Valentina Pastén. "Hipertensión endocrina y embarazo". Tesis de Bioquimica. Pontifica Universidad Catolica de Chile. Santiago, Chile.
4. 2020. Francisco Muñoz MD. Beca de subespecialidad de Endocrinologia Facultad de Medicina UC. Unidad de Biologia Molecular. Pontifica Universidad Catolica de Chile. Santiago, Chile.
5. 2020. Thomas Uslar MD. Beca de subespecialidad de Endocrinologia Facultad de Medicina UC. Unidad de Biologia Molecular. Pontifica Universidad Catolica de Chile. Santiago, Chile.
6. 2020. Maria Jose Riquelme MD. Beca de subespecialidad de Endocrinologia Facultad de Medicina UC. Unidad de Biologia Molecular. Pontifica Universidad Catolica de Chile. Santiago, Chile.
7. 2020. Raiza Garcia MD. Beca de subespecialidad de Endocrinologia Facultad de Medicina UC. Unidad de Biologia Molecular. Pontifica Universidad Catolica de Chile. Santiago, Chile.
8. 2020. Stefano Machiavello MD. Beca de subespecialidad de Endocrinologia Facultad de Medicina UC. Unidad de Biologia Molecular. Pontifica Universidad Catolica de Chile. Santiago, Chile.
9. 2020. Daniela Mellado. “Tecnología asociada a la identificación del componente inflamatorio y biomarcadores tempranos al Hiperaldosteronismo primario (HAP)”. Tesis de Bioquimica & Unidad Extramural. Pontifica Universidad Catolica de Chile - PUCV. Santiago, Chile.
10. 2018-2019. Helena Vogler. "Desarrollo de una tecnología de marcación fluorescente de lipidos y proteínas de nanovesículas utiles en la identificacion de exosomas". Unidad Extramural Biologia. Pontifica Universidad Catolica de Chile. Santiago, Chile.
11. 2015-2016. Paula Villarzú Zuleta. “Estudio del biomarcador temprano NGAL en hipertensos esenciales”. Tesis de Quimica y Farmacia. Pontifica Universidad Catolica de Chile & Universidad San Sebastian. Santiago, Chile.
12. 2013-2014. Biochemistry, PUC. Mr. Agustin Benitez Sierra. Tesis de pregrado para optar al título de
Bioquímico (PUC). “Implementación y validación de un método para la Medición simultanea de cortisol y cortisona en suero por cromatografía liquida con espectrometría de masas en tándem (LC-MS/MS).
13. 2011-2012. Biochemistry USACH-PUC. Ms. Alejandra Tapia Castillo. Tesis de pregrado para optar al título de Bioquímico (USACH). “Papel de la GTPasa pequeña RAC1 en la etiopatogenia de la hipertensión arterial”
14. 2010-2011. Biologist PUCV-PUC. Mr. Cristobal Fuentes Zuñiga. Tesis de pregrado para optar al título de Biólogo (PUCV). “Rol de los esteroides sexuales en la regulación de la enzima quimérica (CYP11B1/B2) y su relación con el hiperaldosteronismo familiar tipo 1”

DIRECTOR/SUPERVISOR GRADUATE THESIS (LEADING TO A PH.D)
1. 2016-2020. Eric Barros MD. “Renal exosomes and their role in primary aldosteronism: an in vitro and in vivo approach”. Director de Tesis de Doctorado (Ciencias Medicas). Pontifica Universidad Catolica de Chile, Santiago, Chile.
2. 2018. PhDc Domenica de Santis. “Nanovesicles and microelements”. Colaboracion internacional en Tesis de Doctorado (Ciencias Medicas) con UNIVERSITY OF Verona (Italia) & Pontificia Universidad Catolica de Chile (Chile).
3. 2014-2017. Alejandra Tapia Castillo. “Regulación de la enzima 11b-Hidroxiesteroide deshidrogenasa tipo 2 (11bHSD2) por miRNA y su asociación con hipertensión arterial”. Director de Tesis de Doctorado (Ciencias Medicas). Pontifica Universidad Catolica de Chile & Universidad del Desarrollo (Dr Gabriela Repetto), Santiago, Chile.

DIRECTOR/SUPERVISOR POSTDOCTORATE
1. 2020-2022. Alejandra Tapia Castillo. CONICYT/ANID POSTDOCTORADO 3200646. “Exosomes and exosomal miRNAs as potential early biomarkers in mineralocorticoid arterial hypertension. Pontificia Universidad Catolica de Chile. Santiago, Chile.


Difusión y Transferencia


SCIENTIFIC COMMITIES and SCIENTIFIC SOCIETIES MEMBERSHIP.
1. Sociedad Chilena de Endocrinologia y Diabetes (SOCHED)
2. Endocrine Society (ENDO)
3. American Heart Association (AHA)
4. American society of Nephrology (ASN)
5. International society for extracellular vesicles (ISEV)
6. International society of Endocrinology (ISE)

BOOK CHAPTERS
1. 2021. Cristian Carvajal*, Alejandra Tapia & Carlos Fardella. Chapter “Apparent Mineralocorticoid excess”. Editor Massimiliano Caprio, Fabio Fernandes-Rosa. In Book “Endocrinology. Hydro Saline Metabolism: Epidemiology, Genetics, Pathophysiology, Diagnosis and Treatment" Editorial Springer Nature Switzerland AG, 2021.
2. 2018. Cristian Carvajal* & Jose Luis Santos. Conceptos básicos de Genetica y Epigenetica. Editor Eugenio Arteaga. In Book “Endocrinologia Clinica" Segunda version 2018. SBN: 978-956-220-402-6Editorial: MEDITERRANEOEdicion/Año: 2018Nº de páginas: 492
3. 2018. Cristian Carvajal & Carlos Fardella. Hiperaldosteronismo Primario. Editor Eugenio Arteaga. In Book “Endocrinologia Clinica" Segunda version 2018. SBN: 978-956-220-402-6 Editorial: MEDITERRANEOEdicion/Año: 2018Nº de páginas: 492
4. 2017. Simonetta Friso*, Cristian Carvajal*, Carlos Fardella, Oliviero Olivieri. Ch.7: “Epigenetics and arterial hypertension: evidence and perspectives”. Editor Jeffrey Laurence. In Book “Translating Epigenetics to the Clinic “, Ed Elsevier. Pages 159–184,January 2017. (*equal contribution). ISBN 978-0-12-800802-7
5. 2016. Cristian Carvajal, Cecilia Mellado. Cap. 31 Genetica y Biologia Molecular, p496-526. Editor Eugenio Arteaga. In Book “Endocrinología Ginecológica”. 2016. ISBN: 978-956-220-381-4.

PATENTS APLICATIONS
1. PCT 2015-00124 (3179285) 16 de enero 2015. “Nuevos inhibidores de la enzima 11beta-hidroxisteroide deshidrogenasa tipo 1”

MEETING PRESENTATIONS:
2016
: Cristian A. Carvajal, Jaime Lizama-González, Tapia-Castillo A, Virginia Iturrieta, Carolina Valdivia, Carlos F. Lagos,René Baudrand, Carmen Campino,Andrea Vecchiola,Carlos E. Fardella. Serum Lipocalin-2/NGAL as potential biomarker of mineralocorticoid activity in subjects with decreased 11BHSD2 activity. ALDOSTERONE CONFERENCE, Boston 2016

2016
: Cristian A. Carvajal, Tapia-Castillo A, Virginia Iturrieta, Carolina Valdivia, Carlos F. Lagos, René Baudrand,Carmen Campino, Andrea Vecchiola,Carlos E. Fardella1, Serum Lipocalin-2/NGAL as potential biomarker of mineralocorticoid activity in subjects with decreased 11BHSD2 activity . ENDO, BOSTON 2016

2016
: Alejandra TapiaCastillo,Virginia Iturrieta,Fidel Allende,CarmenCampino, Alejandro MartínezAguayo,Hernan Garcia,Doris Muñoz,Maria Paulina Rojas, Andrea Vecchiola,Gabriela Repetto,Rene Baudrand,Carlos E, Fardella,and Cristian A Carvajal. Mir488 and Mir615 Identified in Urinary Exosome As Potential Modulators of HSD11B2 Expression. ENDO, BOSTON 2016

2016
: Alejandro Martínez-Aguayo*1, Carmen Campino1, Rene Baudrand1, Cristian A Carvajal1, Hernan Garcia1, Marlene Aglony2, Rodrigo Bancalari1, Lorena Garcia3, Carolina A Loureiro2, Andrea Vecchiola1, Alejandra Tapia1, Carolina P Valdivia1, Cristobal A Fuentes1, Carlos F Lagos1, Sandra Solari1, Fidel Allende1, Alexis Kalergis2 and Carlos E Fardella1. Higher Mineralocorticoid and Vascular Remodeling B

2016
: Fidel Allende*1, Sandra Solari1, Cristian A Carvajal1, Carmen Campino1, Carolina P Valdivia1, Alejandro Martinez2, Alejandra Tapia1, Andrea Vecchiola1, Carlos F Lagos1, Agustin Benitez3, Hernan Garcia1, Rene Baudrand1, Maria Paulina Rojas1, Patricio E Silva1, Doris Muñoz1, Cristobal A Fuentes1, Rodrigo Bancalari1 and Carlos E Fardella1. Serum Versus Urinary Cortisol/Cortisone Ratio Measured By LC-

2016
: Carlos F. Lagos,1,2 Andrea Vecchiola,1,2 Cristobal A. Fuentes,1 Carmen Campino1,2, Cristian A. Carvajal,1,2 Rene Baudrand1 and Carlos E. Fardella1,2. Identification Of Novel Non-Steroidal Mineralocorticoid Receptor Modulators Through Structure-Based Approaches. Aldosterone Conference 2016.

2016
: Cristian A. Carvajal1,3, Paula Villarzú-Zuleta1,2, Jaime Lizama-González1, Tapia-Castillo A1, Virginia Iturrieta1, Carolina Valdivia1, Carlos F. Lagos1,2, René Baudrand1, Carmen Campino1,3, Andrea Vecchiola1,3, Carlos E. Fardella1,3. Serum Lipocalin-2/NGAL as potential biomarker of mineralocorticoid activity in subjects with decreased 11BHSD2 activity. Aldosterone Conference 2016.

2016
: Tapia-castilo -, Alejandra ., Lizama Jaime., Valdivia Carolina ., Ortiz David., Campino Carmen., Allende Fidel., Solari Sandra., García Hernan., Martínez-Aguayo, Alejandro., Vecchiola, Andrea., Repetto, Gabriela., Baudrand, René., Fardella, Carlos.,Carvajal, Cristian. “Un alto consumo de sal afecta la expresión de MicroRNA asociado a la expresión de HSD11B2 en población pediátrica. II Congreso Ch

2016
: Carvajal CA, Tapia-Castillo A. SERUM CORTISONE AND CORTISOL/CORTISONE RATIO AS TOOL TO IDENTIFY SUBJECTS WITH SEVERE AND PARTIAL 11BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 2 DEFICIENCIES. ACT CONGRESO KOREA 2016 26th Meeting of the International Society of Hypertension (Hypertension Seoul 2016) 24-29 September 2016 in Seoul, Korea. Travel award.

2016
: David Ortiz Canales(1), Eric Barros Lamus(1), Alejandra Tapia Castillo(1), Carolina Valdivia Cristián Carvajal Maldonado(1). EVALUACIÓN IN VITRO DE LA ACTIVIDAD MINERALOCORTICOIDEA MEDIADA POR miRNA PRESENTES EN EXOSOMAS DE CÉLULAS EPITELIALES POLARIZADAS. CONGRESO SOCHED 2016 SERENA.

2016
: Alejandra Tapia Castillo(1), Carolina Valdivia Pizarro(2), Carlos Fardella Bello(2), Cristian Carvajal et al. UNA ALTA INGESTA DE SODIO SE ASOCIA A MAYOR EXPRESIÓN DE MICRORNA BLANCOS DE LA 11?HSD2 EN SUJETOS PEDIÁTRICOS. CONGRESO SOCHED 2016 SERENA.

2016
: Carmen Campino (1,5); Alejandro Martinez-Aguayo (2); Rene Baudrand (2); Cristian Carvajal Carlos Fardella (1,5). ADRENAL DYSREGULATION IN CHILDREN WHO WERE BORN EXTREMELY PREMATURE: A PILOT STUDY. ECE Alemania 2016

2017
: Cristian Carvajal. Conferencia "Hipertensión arterial de origen mineralocorticoide”. ciclo de seminarios 2017 de nuestro ICBM. Instituto de Ciencias Biomédicas, Universidad Autónoma de Chile, Julio, 2017

2017
: Campino, Carolina Valdivia, Andrea Vecchiola, Carlos Lagos, Carlos E. Fardella, Cristian A. Carvajal Eric Barros, Jaime Lizama, Fidel Allende, Sandra Solari, Hernán García, Alejandro Martínez-Aguayo, Gabriela Repetto, Marlene Aglony, Rene Baudrand, Carlos F Salomon Alejandra Tapia Castillo A high sodium diet is associated with increased miRNA-1205 detected in urinary exosomes of pediatrics subjec

2017
: Cristian A Carvajal, Alejandra Tapia-Castillo, David Ortiz, Carolina P Valdivia and Carlos E Fardella Alejandra Tapia Castillo "Free NGAL and NGAL-MMP9 Complex As Potential Biomarkers of Partial Deficiencies of Enzyme 11?-Hydroxysteroid Dehydrogenase Type 2 (11?HSD2)" Endo Meeting 2017 April- 1-4 Orlando EEUU

2017
: BARROS, E, CARVAJAL CA ET AL. Polarized epithelial cells release exosomes loaded with miRNAs capable of interacting with HSD11B2 and MR genes European Congress of Endocrinology 2017 (ECE) May-20-23 Lisbon Portugal

2017
: "POLIMORFISMO RS6810951 EN GEN DEL RECEPTOR DE MINERALOCORTICOIDES NR3C2 SE ASOCIA A MAYOR HIPERTENSIÓN ARTERIAL EN POBLACIÓN PEDIÁTRICA CHILENA " XXVII Congreso Chileno de Endocrinología y Diabetes Nov 9-12 Puerto Varas Chile

2017
: ESTUDIO IN VITRO EN CÉLULAS DEL TÚBULO PROXIMAL RENAL PARA IDENTIFICAR EL ROL DE ALDOSTERONA EN LA LIBERACIÓN Y CARGO DE EXOSOMAS XXVII Congreso Chileno de Endocrinología y Diabetes Nov 9-12 Puerto Varas Chile

2017
: SUJETOS CON DEFICIENCIA PARCIAL DE ENZIMA 11?HSD2 PRESENTAN MENOR CONCENTRACIÓN Y TAMAÑO DE EXOSOMAS URINARIOS XXVII Congreso Chileno de Endocrinología y Diabetes Nov 9-12 Puerto Varas Chile

2017
: Cristian Carvajal. "Hipertensión arterial de origen mineralocorticoide”. ciclo de seminarios 2017 Instituto de Ciencias Biomédicas, Universidad Autónoma de Chile jul-17 Santiago Chile

2017
: (Key Speaker) Cristian Carvajal . Mineralocorticoid Endocrine hypertension Congreso de Quimica Clinica 2017 sept-17 Santiago Chile

2017
: Cristian Carvajal. Mineralocorticoid Endocrine hypertension UQCCR Scientist Meeting oct-17 Brisbane Australia

2017
: (Key Speaker) Cristian Carvajal. Mineralocorticoid Endocrine hypertension Hudson-MRI Scientist Meeting nov-17 Melbourne Australia

2017
: Eric Barros, David Ortiz, Jose Vicente Gonzalez, Carlos Salomón, Cristian Carvajal et al. Polarized epithelial cells release exosomes loaded with miRNAs capable of interacting with HSD11B2 and MR genes. 19th ECE 2017.

2017
: Alejandra Tapia-Castillo, Carlos Salomón, Cristian Carvajal et al. A high sodium diet is associated with increased miRNA-1205 detected in urinary exosomes of pediatrics subjects: Potential epigenetic link of HSD11B2 and salt. 42th Aldosterone Conference 2017.

2017
: Cristian Carvajal. 32534 - Free NGAL and NGAL-MMP9 Complex As Potential Biomarkers of Partial Deficiencies of Enzyme 11?-Hydroxysteroid Dehydrogenase Type 2 (11?HSD2). ENDO 2017, April 1-4 in Orlando, Florida.

2018
: (Key Speaker) Cristian Carvajal - Hipertensión arterial endocrina y exosomas. www.imii.cl Workshop Immunología & Inmunoterapia. PUC, Santiago, Chile. (invitado) 05-11-18 Santiago Chile

2018
: (Key Speaker) Invited Cristian Carvajal Mineralocorticoid AHT and exosomes. http://csbiol.udec.cl/curso-internacional-de-postgrado-extracellular-vesicles-and-exosomes-symposium-focusing-on-pregnancy-and-cancer/ Extacellular vesicles and exosomes symposium. Concepción, Chile. (invitado) 08-10-18 Santiago Chile

2018
: Estudio de transcriptómica de mirna y proteómica en exosomas urinarios de sujetos con exceso aparente de mineralocorticoides no clásico (AME-NC). XXIX Congreso SOCHED, Coquimbo, Chile. 09-11-18 Santiago Chile

2018
: NUEVA VARIANTE PATOGENICA HETEROCIGOTA C XXIX Congreso SOCHED, Coquimbo, Chile.09-11-18 Santiago Chile

2018
: Urinary exosomes as potential early biomarkers for mineralocorticoid-dependent hypertension ENDO 2018 17-03-18 Chicago USA

2018
: Renal tubular exosomes modulate extracellular levels of ATP in a nephron-segment specific fashion . Second annual meeting of the Netherlands Society for Extracellular Vesicles (NLSEV) 09-11-18 Amsterdam UMC AMC, Collegezaal 4 The Netherlands

2018
: (Key Speaker) Invited Cristian Carvajal. Hipertensión arterial endocrina IV congreso chileno de Hipertension arterial 16-08-18 Santiago Chile

2019
: Aldosterone to-Renin Ratio predicts cardiometabolic disorders in subjects without classic primary aldosteronism. https://www.endocrine.org/endo-2019 Endocrine Society March 23-26, 2019 New Orleans, LA USA

2019
: Differential miRNA-Transcriptomic and Proteomic Profile in Urinary Exosomes of Subjects with "Nonclassic" Apparent Mineralocorticoid Excess Syndrome https://www.endocrine.org/endo-2019 Endocrine Society March 23-26, 2019 New Orleans, LA USA

2019
: Transcriptomic and proteomic studies in urinary exosomes of subjects with mineralocorticoid arterial hypertension http://www.aldosterone.org Intertational Aldosterone Conference March 21-22, 2019 New Orleans, LA USA

2019
: A novel compound heterozygous pathogenic variant (R213C/R337C) in the HSD11B2 gene as cause of apparent mineralocorticoids excess http://www.aldosterone.org Intertational Aldosterone Conference March 21-22, 2019 New Orleans, LA USA

2019
: International Oral Presentation Registered Barros E., Carvajal C, Eric Barros, Arntz O, van de Loo F., Hoenderop J., Bindels R., Rigalli J.P. https://www.asemv.org/meetings/annual-meeting/ ASEMV American society for Exosomes and Microvesicles October 6-10, 2019 California USA

2019
: Análisis transcriptómico de sujetos con exceso aparente de mineralocorticoide no clásico identifica los miR-192-5p como potenciales biomarcadores asociados a este fenotipo https://hipertension.cl/congreso-2019/ V Congreso Chileno de Hipertensión Arterial August 22 al 24, 2019 Santiago CHILE

2019
: Alejandra Tapia Castillo2, Andrea Vecchiola2, Carlos Fardella2, Cristian Carvajal2 Eric Barros2, Morag Young1, MIR-192-5P, MIR-204-5P Y LET-7I-5P COMO POTENCIALES BIOMARCADORES DEL FENOTIPO DE EXCESO APARENTE DE MINERALOCORTICOIDE NO CLÁSICO (NC-AME). www.soched.cl XXX Congreso Chileno de Endocrinología y Diabetes 2019. Viña del Mar, Chile. 19-22 Nov 2019 Santiago CHILE

2019
: National conference INVITED Cristian Carvajal Hipertensión arterial endocrina y vesículas extracelulares. www.soched.cl XXX Congreso Chileno de Endocrinología y Diabetes 2019. Viña del Mar, Chile. 19-22 Nov 2019 Santiago CHILE

2020
: Nacional Conferencia Invitado Cristian Carvajal Hipertensión arterial endocrina y vesículas extracelulares XXX congreso SOCHED http://soched.cl/web/2020/07/06/7646/ 15-may Virtual Chile

2020
: Cristian Carvajal Eric Barros Lamus3, Juan Pablo Rigalli1, JoostHoenderop1, René Bindels2, Andrea Vecchiola Cardenas3, Alejandra Tapia Castillo3, Carlos Fardella Bello4, Cristian Carvajal2 Alejandra Tapia "PERFIL PROTEÓMICO DE EXOSOMAS URINARIOS IDENTIFICA A ORM1 COMO POTENCIAL BIOMARCADOR DEL HIPERALDOSTERONISMO PRIMARIO." XXX congreso SOCHED http://soched.cl/web/2020/07/06/7646/ 15-may Virtual C

2020
: Nacional Comunicación Oral Inscrito Cristian Carvajal Alejandra Tapia Castillo2 , Eric Barros2 , Andrea Vecchiola2 , Morag Young1 , Carlos Fardella2 , Cristian Carvajal2 Alejandra Tapia MIR-192-5P, MIR-204-5P Y LET-7I-5P COMO POTENCIALES BIOMARCADORES DEL FENOTIPO DE EXCESO APARENTE DE MINERALOCORTICOIDE NO CLÁSICO (NC-AME). XXX congreso SOCHED http://soched.cl/web/2020/07/06/7646/ 15-may Virtual

2020
: Nacional Comunicación Oral Inscrito Carlos Fardella Andrea Vecchiola Cardenas2, SumieKato Cardemil1, Francisca Liberona Núñez1, Alejandra Tapia Castillo2, Cristián Carvajal Maldonado4, Cristina Goens Guzmán3, Carlos Fardella Bello4 Alejandra Tapia ROL DE LA DIFERENCIACIÓN Y LA ALDOSTERONA EN LA LIBERACIÓN Y CARGO DE EXOSOMAS EN CÉLULAS ADIPOSAS HUMANAS. XXX congreso SOCHED http://soched.cl/web/20

2020
: Internacional Poster Inscrito Carlos Fardella Andrea Vecchiola, PhD1, Sumie Kato, Bq1, Francisca Liberona, Bq1, Alejandra Tapia-Castillo, PHD2, Cristian A. Carvajal, PhD1, Maria Cristina Goens, Dra, MD1, Mauricio A. Cuello, Dr, MD1, Carlos E. Fardella, Dr, MD1. Alejandra Tapia Role of Adipocyte Hyperplasia and Hypertrophy in the Release and Charge of Exosomes in Human Fat Cells. ENDO 2020 doi: 10

2020
: Nacional Comunicación Oral Inscrito Cristian Carvajal Maria Gabriela Ugarte Solari1, Alejandra Tapia Castillo1, Jorge Pérez López1, Andrea Vecchiola Cardenas1, Carlos Fardella Bello1, Cristián Carvajal Maldonado1 Alejandra Tapia LIPOCALINAS ORM1 Y LCN2 ESTáN ELEVADOS EN SUJETOS CON SOSPECHA DE HIPERALDOSTERONISMO PRIMARIO” XXXI congreso SOCHED http://soched.cl/web/invitacion-2/ 04-11-20 Virtual

2020
: Nacional Comunicación Oral Inscrito Cristian Carvajal Alejandra Tapia Castillo1, Cristián Carvajal Maldonado1, Andrea Vecchiola Cardenas1, Carlos Fardella Bello1 Alejandra Tapia PERFIL METABOLÓMICO DE SUJETOS CON SINDROME DE EXCESO APARENTE DE MINERALOCORTICOIDES NO CLÁSICO: UNA NUEVA FORMA DE HIPERTENSIÓN ARTERIAL SUBDIAGNOSTICADA XXXI congreso SOCHED http://soched.cl/web/invitacion-2/ 04-11-20

2020
: Nacional Comunicación Oral Inscrito Carlos Fardella Andrea Vecchiola Cárdenas1, Alejandra Tapia Castillo4, René Baudrand Biggs2, Alexis Kalergis Parra3, Cristián Carvajal Maldonado4, Carlos Fardella Bello4 Alejandra Tapia ASOCIACION ENTRE ADIPOQUINAS Y LOS COMPONENTES DEL SINDROME METABOLICO.” XXXI congreso SOCHED http://soched.cl/web/invitacion-2/ 04-11-20 Virtual Chile


Premios y Distinciones

  •   Minisabbatical Programe UC

    PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

    Chile, 2017

    2017 Minisabbatical Programe. University of Queensland, Brisbane, Australia. Granted by Pontificia Universidad Catolica de Chile

  •   Collaborative Grant

    UNIVERSITY OF QUEENSLAND

    Chile, 2017

    2017 Universidad del Desarrollo & University of Queensland. Collaborative Grant. Co-I. “Urinary exosomal miRNA profile in pediatrics subjects with partial deficiency of 11BHSD2 enzyme

  •   Best work of the 27th SOCHED meeting

    SOCIEDAD CHILENA DE ENDOCRINOLOGIA Y METABOLISMO

    Chile, 2016

    2016 Best work of the 27th SOCHED meeting. Awarded by Sociedad Chilena de Endocrinologia y Diabetes.

  •   Travel Award to 26th Scientific Meeting of the ISH

    International society of Hypertension

    Chile, 2016

    2016 Travel Award to 26th Scientific Meeting of the ISH. Awarded by International society of Hypertension.

  •   Excellence in doctoral thesis award. Best PhD thesis.

    PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

    Chile, 2014

    2014 Excellence in doctoral thesis award. Best PhD thesis. Awarded by Pontificia Universidad Católica de Chile

  •   Research Grant SOCHED

    SOCIEDAD CHILENA DE ENDOCRINOLOGIA Y METABOLISMO

    Chile, 2012

    2012-2013 Sociedad Chilena de Endocrinologia y Diabetes 2012-04 Grant (PI). “Human Epigenetics”.

  •   Board President. Presidente Mesa en el Curso SOCHED “Tejido adiposo como órgano endocrino: Desde las ciencias fundamentales a la clínica”,

    SOCIEDAD CHILENA DE ENDOCRINOLOGIA Y METABOLISMO

    Chile, 2013

    2013. Board President. Presidente Mesa en el Curso SOCHED “Tejido adiposo como órgano endocrino: Desde las ciencias fundamentales a la clínica”, 23 y 24 de agosto 2013. Centro de Eventos Club Manquehue, Santiago.

  •   Lecture. Conferencia SOCHED 2013 “Genoma y Endocrinología”. XXIV Congreso Chileno de Endocrinologia y Diabetes

    PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

    Chile, 2013

    2013. Lecture. Conferencia SOCHED 2013 “Genoma y Endocrinología”. XXIV Congreso Chileno de Endocrinologia y Diabetes. Viña del Mar-Chile, 7-10 de Noviembre, 2013.

  •   2013. Board President. Presidente Mesa congreso SOCHED 2013

    SOCIEDAD CHILENA DE ENDOCRINOLOGIA Y METABOLISMO

    Chile, 2013

    2013. Board President. Presidente Mesa congreso SOCHED 2013. XXIV Congreso Chileno de Endocrinologia y Diabetes. Viña del Mar-Chile, 7-10 de Noviembre, 2013.

  •   Presidential Abstract Award. 95th The Endocrine Society 2013.

    The Endocrine Society

    Estados Unidos, 2013

    2013. Presidential Abstract Award. 95th The Endocrine Society 2013. Carvajal CA et al. CpG methylation in 11beta-hydroxysteroid dehydrogenase type2 promoter is increased in adult essential hypertensives.

  •   Grant 2019 SOCHED

    SOCIEDAD CHILENA DE ENDOCRINOLOGIA Y METABOLISMO

    Chile, 2019

    Grant award

  •   2020 AWARD BEST TRASLATIONAL MEETING ABSTRACT al Mejor Trabajo Traslacional XXXI Congreso SOCHED.

    SOCIEDAD CHILENA DE ENDOCRINOLOGIA Y METABOLISMO

    Chile, 2020

    2020 AWARD BEST TRASLATIONAL MEETING ABSTRACT al Mejor Trabajo Traslacional XXXI Congreso SOCHED. "Lipocalinas ORM1 y LCN2 están elevados en sujetos con sospecha de hiperaldosteronismo primario". Sociedad Chilena de Endocrinologia y Diabetes Nov 2020.

  •   2019 GRANTED Concurso Proyectos de Investigación SOCHED 2019. Proyecto 2019-09.

    SOCIEDAD CHILENA DE ENDOCRINOLOGIA Y METABOLISMO

    Chile, 2019

    2019 GRANTED Concurso Proyectos de Investigación SOCHED 2019. Proyecto 2019-09. "Hiperaldosteronismo primario e inflamación: nuevos biomarcadores"

  •   2019 AWARD BEST MEETING ABSTRACT. XXX SOCHED.

    SOCIEDAD CHILENA DE ENDOCRINOLOGIA Y METABOLISMO

    Chile, 2019

    2019 AWARD BEST MEETING ABSTRACT. XXX SOCHED. “Perfil proteómico de exosomas urinarios identifica a ORM1 como potencial biomarcador del hiperaldosteronismo primario“, Sociedad Chilena de Endocrinologia y Diabetes Nov 2019.

  •   2019 AWARD BEST MEETING ABSTRACT. XXX SOCHED.

    SOCIEDAD CHILENA DE ENDOCRINOLOGIA Y METABOLISMO

    Chile, 2019

    2019 AWARD BEST MEETING ABSTRACT. XXX SOCHED. “mir-192-5p, mir-204-5p y let-7i-5p como potenciales biomarcadores del fenotipo de exceso aparente de mineralocorticoide no clásico”, Sociedad Chilena de Endocrinologia y Diabetes Nov 2019.

  •   2018 SHORT INTERNSHIP ABROAD (Pasantia Breve en Extranjero) by VRI-PUC

    PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

    Chile, 2018

    2018 SHORT INTERNSHIP ABROAD (Pasantia Breve en Extranjero) by VRI-PUC. HUDSON MRI-Monash University, Melbourne, Australia. Julio-2019.

  •   2018 OUTSTANDIG ABSTRACT AWARD. ENDOCRINE SOCIETY MEETING

    ENDOCRINE SOCIETY (USA)

    Estados Unidos, 2018

    2018 OUTSTANDIG ABSTRACT AWARD. ENDOCRINE SOCIETY MEETING, SAN FRANCISCO USA.

  •   2017 MINISABBATICAL PROGRAM.

    PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

    Chile, 2017

    2017 MINISABBATICAL PROGRAM. University of Queensland, Brisbane, Australia. Granted by Facultad de Medicina, Pontificia Universidad Catolica de Chile.

  •   2017 AWARD BEST MEETING ABSTRACT. III Meeting Chileno de Hipertensión Arterial.

    SOCIEDAD CHILENA DE HIPERTENSION

    Chile, 2017

    2017 AWARD BEST MEETING ABSTRACT. III Meeting Chileno de Hipertensión Arterial. “Exosomas urinarios como potenciales biomarcadores temprano de HTA Mineralocorticoide”. Alejandra Tapia Castillo, Carlos Fardella, Carlos Salomon, Cristian Carvajal et al. Santiago, 2017.

  •   2016 BEST PUBLISHED ARTICLE IN ENDOCRINOLOGY 2015-2016 (CHILE).

    SOCIEDAD CHILENA DE ENDOCRINOLOGIA Y METABOLISMO

    Chile, 2016

    2016 BEST PUBLISHED ARTICLE IN ENDOCRINOLOGY 2015-2016 (CHILE). The Expression of RAC1 and Mineralcorticoid Pathway-Dependent Genes Are Associated With Different Responses to Salt Intake American Journal of Hypertension 2015 June, 28 (6): 722-728 Alejandra Tapia-Castillo, Cristian A. Carvajal, Carlos E. Fardella. Et al. SOCHED 2016. Santiago, 2016.

  •   2016 PRESIDENTIAL POSTER AWARD - ENDO SOCIETY MEETING

    THE ENDOCRINE SOCIETY

    Chile, 2016

    2016 PRESIDENTIAL POSTER AWARD. Mir-488 and Mir-615 Identified in Urinary Exosome As Potential modulators of HSD11B2 Expression. Alejandra Tapia-Castillo, Carlos E Fardella and Cristian A Carvajal et al. ENDO 2016.


 

Article (69)

Clinical and molecular characterization of Chilean patients with X-linked hypophosphatemia.
Comparing Approaches to Normalize, Quantify, and Characterize Urinary Extracellular Vesicles.
Extracellular vesicles regulate purinergic signaling and epithelial sodium channel expression in renal collecting duct cells.
Proteomic Profile of Urinary Extracellular Vesicles Identifies AGP1 as a Potential Biomarker of Primary Aldosteronism
Classic and Nonclassic Apparent Mineralocorticoid Excess Syndrome
Detection of a novel severe mutation affecting the CYP21A2 gene in a Chilean male with salt wasting congenital adrenal hyperplasia
Urinary sodium-to-potassium ratio and plasma renin and aldosterone concentrations in normotensive children
Downregulation of exosomal miR-192-5p and miR-204-5p in subjects with nonclassic apparent mineralocorticoid excess
The Aldosterone/Renin Ratio Predicts Cardiometabolic Disorders in Subjects Without Classic Primary Aldosteronism
Clinical, Biochemical, and Genetic Characteristics of "Nonclassic" Apparent Mineralocorticoid Excess Syndrome
Depressive symptoms are associated with higher morning plasma cortisol in primary care subjects.
Serum Cortisol and Cortisone as Potential Biomarkers of Partial 11 beta-Hydroxysteroid Dehydrogenase Type 2 Deficiency
Sodium Intake Is associated With Endothelial Damage Biomarkers and Metabolic Dysregulation
Epigenetics and Arterial Hypertension: Evidences and Perspectives
Hypertensive Patients That Respond to Aldosterone Antagonists May Have a Nonclassical 11 beta-HSD2 Deficiency
Urinary Exosomes and Their Cargo: Potential Biomarkers for Mineralocorticoid Arterial Hypertension?
Citosine-Adenine-Repeat Microsatellite of 11 beta-hydroxysteroid dehydrogenase 2 Gene in Hypertensive Children
Cortisol/cortisone ratio and matrix metalloproteinase-9 activity are associated with pediatric primary hypertension
Usefulness and Pitfalls in Sodium Intake Estimation: Comparison of Dietary Assessment and Urinary Excretion in Chilean Children and Adults
Epigenetics and arterial hypertension: the challenge of emerging evidence
Metabolic syndrome and its components are strongly associated with an inflammatory state and insulin resistance in the pediatric population
The Expression of RAC1 and Mineralocorticoid Pathway-Dependent Genes are Associated With Different Responses to Salt Intake
HEPATIC STEATOSIS AS DIABETES TYPE 2 PREDICTOR
High sodium intake is associated with increased glucocorticoid production, insulin resistance and metabolic syndrome
Identification of novel 11 beta-HSD1 inhibitors by combined ligand- and structure-based virtual screening
LC-MS/MS Method for the Simultaneous Determination of Free Urinary Steroids
Polymorphisms in the RAC1 Gene Are Associated With Hypertension Risk Factors in a Chilean Pediatric Population
Age-Related Changes in 11 beta-Hydroxysteroid Dehydrogenase Type 2 Activity in Normotensive Subjects
Different effects of progesterone and estradiol on chimeric and wild type aldosterone synthase in vitro
Positive association between aldosterone-renin ratio and carotid intima-media thickness in hypertensive children
The estimation of visceral adipose tissue with a body composition monitor predicts the metabolic syndrome
11 beta-Hydroxysteroid Dehydrogenase Type 2 Polymorphisms and Activity in a Chilean Essential Hypertensive and Normotensive Cohort
A New Presentation of the Chimeric CYP11B1/CYP11B2 Gene With Low Prevalence of Primary Aldosteronism and Atypical Gene Segregation Pattern
Angiotensin-converting enzyme insertion/deletion polymorphism is associated with severe hypoxemia in pediatric ARDS
Birth weight is inversely associated with blood pressure and serum aldosterone and cortisol levels in children
Overexpression of 11 beta-hydroxysteroid dehydrogenase type 1 in visceral adipose tissue and portal hypercortisolism in non-alcoholic fatty liver disease
A de novo unequal cross-over mutation between CYP11B1 and CYP11B2 genes causes familial hyperaldosteronism type I
Frequency of Familial Hyperaldosteronism Type 1 in a Hypertensive Pediatric Population Clinical and Biochemical Presentation
Increased urinary glucocorticoid metabolites are associated with metabolic syndrome, hypoadiponectinemia, insulin resistance and beta cell dysfunction
Overexpression of hepatic 5 alpha-reductase and 11 beta-hydroxysteroid dehydrogenase type 1 in visceral adipose tissue is associated with hyperinsulinemia in morbidly obese patients
11 beta-hydroxysteroid dehydrogenase type-2 and type-1 (11 beta-HSD2 and 11 beta-HSD1) and 5 beta-reductase activities in the pathogenia of essential hypertension
Aldosterone Promotes Autoimmune Damage by Enhancing Th17-Mediated Immunity
Aldosterone, Plasma Renin Activity, and Aldosterone/Renin Ratio in a Normotensive Healthy Pediatric Population
Increased levels of oxidative stress, subclinical inflammation, and myocardial fibrosis markers in primary aldosteronism patients
Overexpression of 11 beta-Hydroxysteroid Dehydrogenase Type 1 in Hepatic and Visceral Adipose Tissue is Associated with Metabolic Disorders in Morbidly Obese Patients
11 beta-Hydroxysteroid Dehydrogenase Type 1 is Overexpressed in Subcutaneous Adipose Tissue of Morbidly Obese Patients
Primary aldosteronism can alter peripheral levels of transforming growth factor beta and tumor necrosis factor alpha
A novel adrenocorticotropin receptor mutation alters its structure and function, causing familial glucocorticoid deficiency
Marcadores de inflamación endotelial subclínica en una familia con hiperaldosteronismo familiar tipo I por mutación de novo
Microribonucleic acid-21 increases aldosterone secretion and proliferation in H295R human adrenocortical cells
Possible pathogenetic role of 11 beta-hydroxysteroid dehydrogenase type 1 (11 beta HSD1) gene polymorphisms in arterial hypertension
Regiones polimórficas del gen 11ß-hidroxiesteroide deshidrogenasa tipo 1 (11ßHSD1) en hipertensión arterial esencial: Posible rol etiopatogénico
Subclinical endothelial inflammation markers in a family with type I familial hyperaldosteronism caused by a de novo mutation
A polymorphic GT short tandem repeat affecting beta-ENaC mRHA expression is associated with low renin essential hypertension
A possible association between primary aldosteronism and a lower beta-cell function
Refractory depression in a patient with peripheral resistance to thyroid hormone (RTH) and the effect of triiodothyronine treatment
Urinary free cortisol is not a biochemical marker of hypertension
New splicing mutation of MEN1 gene affecting the translocation of menin to the nucleous
Asociación de la región microsatélite AGAT del gen receptor de mineralocorticoides con los niveles de actividad renina en hipertensos esenciales
Biochemical and genetic characterization of 11 beta- hydroxysteroid dehydrogenase type 2 in low-renin essential hypertensives
Microsatellite marker AGAT of the mineralocorticoid receptor gene is associated with plasma renin activity in patients with essential hypertension
Congenital lipoid adrenal hyperplasia caused by a novel splicing mutation in the gene for the steroidogenic acute regulatory protein
Free urinary cortisol is elevated in patients with low-renin essential hypertension
Novel intronic mutation of MEN1 gene causing familial isolated primary hyperparathyroidism
Primary aldosteronism and hypertensive disease
Two homozygous mutations in the 11 beta-hydroxysteroid dehydrogenase type 2 gene in a case of apparent mineralocorticoid excess
Two homozygous mutations in the 11?-hydroxysteroid dehydrogenase type 2 gene in a case of apparent mineralocorticoid excess
11 beta-hydroxysteroid dehydrogenase activity in patients with hypertension and low plasma renin activity
Endothelial cell oxidative stress and signal transduction

Abstract (16)

Leptin Is Associated with Serum Aldosterone in Paediatric Subjects, Independently of Body Mass Index, Blood Pressure and Plasma Renin Activity
A Novel Polymorphism in 11 beta-Hydroxysteroid Dehydrogenase Type 2 Gene (HSD11B2) Is Associated with High Urinary Excretion of Tetrahydro-11-Deoxycortisol (THS) in Essential Hypertensive Patients.
A Novel Unequal Cross-Over Mutation between CYP11B1 and CYP11B2 Genes Causes Familial Hyperaldosteronism Type I.
Aldosterone, Plasma Renin Activity and Aldosterone-Renin Ratio in Normotensive Pediatric Population as Screening for Primary Aldosteronism
Central Obesity and the Metabolic Syndrome Are Associated with Portal and Not Systemic Hypercortisolism Supported by the Raise of Urinary Corticosteroid Metabolites
Determination of Aldosterone-to-Renin Ratio in Normotensive Pediatric Population To Be Used as Screening of Primary Hiperaldosteronism.
Primary Familial Hyperaldosteronism Type 1 in Hypertensive Children: Prevalence, Clinical and Biochemical Characteristics
Primary Familial Hyperaldosteronism Type 1 in Hypertensive Children: Prevalence, Clinical and Biochemical Characteristics.
Sleep Disordered Breathing in Children with Ambulatory Blood Pressure Monitoring and Renin Angiotensin System Evaluation
Visceral Hypercortisolism Observed in Central Obesity and Metabolic Syndrome Is Associated with Insulin Resistance and Beta Cell Dysfunction.
COMPARISION OF EXTRAVASCULAR LUNG WATER MEASURED BY TRANSPULMONARY THERMODILUTION AND GRAVIMETRY IN AN ANIMAL MODEL OF ARDS.
CORRELATION OF CARDIAC OUTPUT MEASURED BY TRANSPULMONARY THERMODILUTION AND PULSE CONTOUR ANALYSIS IN A EXPERIMENTAL ARDS MODEL.
MicroRNA-21 Increases Aldosterone Secretion and Proliferation in H295R Human Adrenocortical Cells
Familial hyperaldosteronism type 1: Variation of phenotype expression in the same family
Novel compound heterozygous mutation of the ACTH receptor gene (MC2R) in a familiar glucocorticoid deficiency
NO-mediated OxyHb oxidation is inhibited in vitro by polyphenolic compounds using S-nitroso-homocysteine as a NO donor

BookSection (1)

Ch.7: “Epigenetics and arterial hypertension: evidences and perspectives”.

Letter (2)

Pregnancy normalized familial hyperaldosteronism type I: a novel role for progesterone?
A possible association between primary aldosteronism and a lower beta-cell function - Reply

Proyecto (15)

ADRENAL DYSREGULATION IN CHILDREN BORN EXTREMELY PRETERM=> THE ROLE OF INCREASED MINERALOCORTICOID RECEPTOR ACTIVATION ON BLOOD PRESSURE AND VASCULAR DAMAGE
Aldosterone dysregulation in metabolic syndrome, obesity and inflammation=> clinical and in vitro studies
NOVEL BIOCHEMICAL AND EPIGENETIC STUDIES IN 11BETA-HYDROXYSTEROID DEHYDROGENASE 2 GENE AS A TARGET FOR ENDOCRINE HYPERTENSION.
REGULACIÓN DE LA ENZIMA 11B-HIDROXIESTEROIDE DESHIDROGENASA TIPO 2 (11BHSD2) POR MIRNA Y SU ASOCIACIÓN CON HIPERTENSIÓN ARTERIAL
Nuevos fármacos para el tratamiento de la hipertensión y el síndrome metabólico.
Desarrollo de fármacos para la Hipertensión y Síndrome Metabólico
Instituto Milenio de Inmunología e Inmunoterapia
SALT INTAKE IN ESSENTIAL HYPERTENSION=> STUDIES OF NEW BIOCHEMICAL AND GENETIC MECHANISMS TO IDENTIFY ITS ETIOLOGY
IMPACTO DE LA METILACIÓN DEL PROMOTOR DEL GEN HSD11B2 EN LA GENESIS DE HIPERTENSIÓN ARTERIAL HUMANA Y SU UTILIDAD COMO MARCADOR EPIGENÉTICO
PRIMARY ALDOSTERONISM AND HSD11B2 ENZYME ACTIVITY DEFECTS IN PEDIATRIC POPULATION AND ITS IMPACT ON THE GENERATION OF ENDOTHELIAL INJURY, OXIDATIVE STRESS AND ARTERIAL HYPERTENSION.
NUEVO TEST DIAGNÓSTICO MOLECULAR PARA IDENTIFICAR CAUSAS DE HIPERTENSIÓN ARTERIAL ESENCIAL CON Y SIN SÍNDROME METABÓLICO
EVALUACIÓN CLÍNICO-MOLECULAR DEL ROL DE LA 11beta-HIDROXIESTEROIDE DESHIDROGENASA TIPO 1 (11beta-HSD1) HEPÁTICA Y DE TEJIDO GRASO EN EL DESARROLLO DE SÍNDROME METABÓLICO E INSULINORRESISTENCIA EN OBESOS MÓRBIDOS
EVALUACION CLINICO-MOLECULAR DEL ROL DE LAS DESHIDROGENASAS TIPO 1 Y 2 (11ßHSD1 y 11ßHSD2) EN LA GENESIS DE LA HIPERTENSION ARTERIAL HIPORRENNEMICA.
Evaluación Clínico Molecular del rol de los receptores de glucocorticoides y mineralocorticoides en la génesis de la hipertensión hiporreninemica
Caracterización Clínico-Molecular de la Hipertensión Arterial Hiporreninémica no mediada por Aldosterona

Review (5)

Aldosterone Production and Signaling Dysregulation in Obesity
Primary Aldosteronism and its Impact on the Generation of Arterial Hypertension, Endothelial Injury and Oxidative Stress
Hiperaldosteronismo primario
Primary aldosteronism
Microsatellite marker AGAT of the mineralocorticoid receptor gene is associated with plasma renin activity in patients with essential hypertension [Asociación de la region microsatélite AG at del gen receptor de mineralocorticoidescon los niveles de actividad renina en hipertensos esenciales]
92
Cristian Carvajal

Associate Professor

Endocrinologia

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

63
Carlos Fardella

Profesor Titular

Endocrinología

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

20
Rene Baudrand

Profesor Asociado

Endocrinología

Pontificia Universidad Católica de Chile

Santiago, Chile

15
ALEJANDRA TAPIA

Investigador

Endocrinología

Pontificia Universidad Católica de Chile

Santiago, Chile

13
lorena mosso

profesor asociado

endocrinologia

Pontificia Universidad Catolica de Chile

santiago, Chile

12
Gareth Owen

Profesor Titular

Fisiologia

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

11
Andrea Vecchiola

Profesor Asistente

Endocrinologia

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

10
Carlos Lagos

Profesor Asociado

FACULTAD DE MEDICINA Y CIENCIA

UNIVERSIDAD SAN SEBASTIÁN

SANTIAGO, Chile

9
Alexis Kalergis

Full Professor

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE. FACULTAD DE CIENCIAS BIOLÓGICAS

Santiago, Chile

9
Alejandro Martinez

Profesor Asociado

Pediatría

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago de Chile, Chile

9
Fidel Allende

Quimico

Laboratorios Clinicos

Pontificia Universidad Católica de Chile

Santiago, Chile

9
Lillian Bolte

Medico Staff

Pediatria

Hospital Roberto del Río

Santiago, Chile

8
Carolina Loureiro

Instructor Adjunto

Pediatria

Pontificia Universidad Católica de Chile

Santiago, Chile

8
Sandra Solari

Profesor Asociado

Departamento Laboratorios Clinicos - Facultad de Medicina - PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

7
Oslando Padilla

Estadístico

Salud Pública

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

6
Alex Escalona

Assistant Professor

Cirugía Digestiva

Pontificia Universidad Catolica de Chile

Santiago, Chile

5
Javiera Sateler

Profesor instructor

Ciencias Clínicas

Universidad Católica del Maule

Talca, Chile

5
jose dominguez

Profesor Asistente

Endocrinologia

Pontificia Universidad Catolica de Chile

Santiago, Chile

5
Arnoldo Riquelme

Director UDA Ciencias de la Salud (Carreras de Nutrición y dietética, Fonoaudiología y Kinesiología)

Gastroenterología

Pontificia Universidad Católica de Chile

Santiago, Chile

5
MARCO ARRESE

FULL PROFESSOR

GASTROENTEROLOGY

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

5
Margarita Pizarro

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

4
Alexis Gonzalez

Adjunct Professor

Instituto de Química

Pontificia Universidad Católica de Valparaiso

Valparaíso, Chile

4
Paola Krall

Profesor Auxiliar

Universidad Austral de Chile

Valdivia, Chile

4
Javiera Cornejo

Academica

Medicina Preventiva

FAVET, Universidad de Chile

Santiago, Chile

3
Arnoldo Riquelme

Profesor titular

Gastroenterología

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE, DEPARTAMENTO DE GASTROENTEROLOGÍA

Santiago, Chile

3
Rosemarie Mellado

Jefe de carrera / Académica

Farmacia

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

3
Eugenia Ortiz

Instructor

Medicina Interna

UNIVERSIDAD DE LA FRONTERA. FACULTAD DE MEDICINA

Temuco, Chile

3
Pablo Cruces

MEDICO RESIDENTE

PEDIATRIA

HOSPITAL EL CARMEN DE MAIPU

SANTIAGO, Chile

3
Gonzalo Valdivia

Division Head, Full Professor

Medical School

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

Santiago, Chile

3
Cesar Carvajal

Socio

ACQ

Santiago, Chile

3
Pamela Trejo

Endocrinologist

Internal Medicine

Clinica Alemana Santiago

Santiago, Chile

3
Pablo González

Associate Professor

Molecular Genetics and MIcrobiology

Pontificia Universidad Católica de Chile

Santiago, Chile

3
Tomas Perez-Acle

Full Professor

Computational Biology Lab

Fundación Ciencia para la Vida

Santiago, Chile

2
Luis Michea

PROFESOR ASOCIADO

PROGRAMA FISIOLOGIA Y BIOFISICA

UNIVERSIDAD DE CHILE

Santiago, Chile

2
Claudia Riedel

Full Professor

Life Sciences

Universidad Andres Bello

Santiago, Chile

2
Betty San Martin

Directora

Ciencias Clínicas

UNIVERSIDAD DE CHILE, FAC. CIENCIAS VETERINARIAS Y PECUARIAS

Santiago, Chile

2
ERICK RIQUELME

ASSISTANT PROFESSOR

CENTER FOR INTEGRATIVE BIOLOGY

UNIVERSIDAD MAYOR

SANTIAGO, Chile

2
Sergio Lavandero

Director

Advanced Center for Chronic Diseases (ACCDiS)

UNIVERSIDAD DE CHILE, FAC CIENCIAS QUÍMICAS Y FARMACÉUTICAS

Santiago, Chile

2
Lorena Garcia

Assistant Professor

Bioquimica y Biologia Molecular

UNIVERSIDAD DE CHILE

Santiago, Chile

2
Franco Diaz

Residente

Pediatría

Hospital El Carmen de Maipú

Santiago, Chile

1
Trinidad Montero

postdoctorate

Medicine

Pontificia Universidad Católica de Chile

Santiago, Chile

1
Roberto Candia

Profesor Asistente

Gastroenterologia

Pontificia Universidad Catolica de Chile

Santiago, Chile

1
Juan Tichauer

Bioquímico

Medicina intensiva

Pontificia Universidad Católica de Chile

Santiago, Chile

1
María Rojas

Jefa de Departamento

Medicina Familiar

Pontificia Universidad Católica de Chile

Santiago, Chile

1
Helena Poggi

Coordinadora de Investiagción

División de Pediatría

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

1
Alvaro Huete

Jefe Departamento

Radiologia

Pontificia Universidad Católica de Chile

Santiago, Chile

1
Jorge Jalil

FULL PROFESSOR

ENFS CARDIOVASCULARES

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE, ESCUELA DE MEDICINA

Santiago, Chile

1
Macarena Jiménez

Residente

Endocrinología

Pontificia Universidad Católica de Chile

Santiago, Chile

1
Pia Villarroel

Docente investigador

UNIVERSIDAD MAYOR

Santiago, Chile

1
Paul Vöhringer

Profesor Asociado

Psyquiatría

CLINICA PSIQUIÁTRICA UNIVERSITARIA

Santiago, Chile

1
Benjamín Erranz

Investigador-Docente

Instituto de Ciencias e Innovación en Medicina

Universidad del Desarrollo

Santiago, Chile

1
Fernando Figueroa

Director

Medicina

UNIVERSIDAD DE LOS ANDES

Santiago de Chile, Chile

1
Cristián Amador

Profesor Asistente

Instituto de Ciencias Biomédicas

UNIVERSIDAD AUTONOMA DE CHILE

Santiago, Chile

1
Fernando Avila

Graduate Researcher / PhD Student

Cirugía y Cancer

Imperial College London

London, Reino Unido

1
Maria Ocaranza

Asociate Professor

Cardiovascular Diseases Division

Pontificia Universidad Catolica de Chile

Santiago, Chile

1
Rodrigo Muñoz

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

1
Mariana Cifuentes

Professor

Instituto de Nutricion y Tecnologia de los Alimentos

INTA UNIVERSIDAD DE CHILE

Santiago, Chile

1
Maria Mericq

Profesor Titular

IDIMI

Universidad de Chile

Santiago, Chile

1
Maria Repetto

Profesor Titular

Center for Genetics and Genomics

FACULTAD DE MEDICINA CLINICA ALEMANA-UNIVERSIDAD DEL DESARROLLO

Santiago, Chile

1
Héctor Venegas

Profesor Titular asociado al Centro

Universidad Diego Portales

Santiago, Chile

1
María Rodríguez

Profesora Asistente

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

Santiago, Chile

1
Jose Garrido

Investigador Asociado

UNIVERSIDAD DE CONCEPCION

Concepción, Chile