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María Rodríguez Fernández

Profesora Asociada

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

Santiago, Chile

Líneas de Investigación


Modelamiento Matemático; Biología de Sistemas; Fisiología Cuantitativa; Monitoreo Fisiológico

Educación

  •  Ingeniería Química, UNIVERSIDAD DE SANTIAGO DE COMPOSTELA. España, 2001
  •  PhD Ingeniería Química, UNIVERSIDAD DE VIGO. España, 2007

Experiencia Académica

  •   Profesora Asistente Full Time

    PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

    Ingeniería, Medicina y Ciencias Biológicas

    Santiago, Chile

    2016 - 2021

  •   Profesora Asociada Full Time

    PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

    Ingeniería, Medicina y Ciencias Biológicas

    Santiago, Chile

    2021 - A la fecha

Experiencia Profesional

  •   Principal Scientist Full Time

    Pfizer Inc

    La Jolla, Estados Unidos

    2014 - 2015

  •   Assistant Project Scientist Full Time

    University of California Santa Barbara (UCSB)

    Santa Barbara, Estados Unidos

    2012 - 2014

  •   Research Associate Full Time

    Imperial College London

    London, Reino Unido

    2006 - 2007

Formación de Capital Humano


MENTORING EXPERIENCE
2020-present: M.Sc. Thesis advisor for Diego de la Vega, UC.
2020-present: PhD. Thesis advisor for Rayen Valdivia, UC.
2020-present: PhD. Thesis advisor for Carlos Valle, UC.
2019-present: PhD. Thesis advisor for Javiera Cortés, UC.
2019-present PhD. Thesis advisor for Martín Miranda, UC.
2019-present: PhD. Thesis advisor for Gabriela Vargas, UC.
2019-present: M.Sc. Thesis advisor for Axel Sepúlveda, UC.
2018-2019: M.Sc. Thesis advisor for Alexis Suárez Pinto, Research topic: "Predicting chronotype from non-invasive physiological signals", UC
2017-2019: M.Sc. Thesis advisor for Maria Emilia Fresard Petit, Research topic: "Multiobjective optimization of Machine Learning models for personalized prediction of survival and thrombosis in patients with ovarian cancer", UC

THESIS COMMITTEES
Aug 2016: M.Sc. Thesis committee: Francisco Saitua, “Dynamic Genome-Scale Metabolic Modeling of the Yeast Pichia Pastoris”, Advisor: Eduardo Agosín, UC.
Jan 2017: M.Sc. Thesis committee: Rodrigo González, “Detection, Estimation and Prediction of Ingests for Predictive Control of Artificial Pancreas Systems in Patients with T1DM”, Advisor: Aldo Cipriano, UC.
Feb 2017: M.Sc. Thesis committee: Kritsye Leiva, “Kinetic Modeling for the Optimization of ?eta-Ionone Production in S. Cerevisiae”, Advisor: Eduardo Agosín, UC.
June 2017: PhD. Thesis committee: Pierre Chelle, “Towards a Patient-Specific Definition of the Antihemophilic Factor Target Rate from Thrombin Generation: Contribution of Experimental Approaches and Dynamic Models of the Coagulation Cascade”, Advisor: Michel Cournil, Ecole des Mines de Saint-Etienne, France.
October 2017 PhD. Thesis committee: Henry Humberto León Ariza, “Development of a mathematical model to establish the physiological relationship between inflammation and the autonomic nervous system”, Advisor: Daniel Alfonso Botero Rosas, Universidad de La Sabana, Colombia.
October 2017 M.Sc. Thesis committee: Francisco Matías Pinto Chávez, “Construcción de un modelo dinámico basado en interacciones metabólicas entre especies del microbioma intestinal”, Advisor: Daniel Garrido Cortés, UC.
May 2020 PhD. Thesis committee: Rodrigo Santibáñez. “Development of rule-based models for regulatory mechanisms of gene expression and bacterial metabolism”, Advisor: Daniel Garrido Cortés, UC.


Difusión y Transferencia


2017-Teaching "Physiological Monitoring in the IoT Era" in the Diploma "Internet of Things and the Industry 4.0", Pontificia Universidad Católica de Chile, Santiago, Chile (UC).

Journal reviewer: Bioinformatics, Bioprocess and Biosystems Engineering, BMC Systems Biology, Cells, Communications in Nonlinear Science and Numerical Simulation, Computers & Chemical Engineering, IEEE/ACM Transactions on Computational Biology and Bioinformatics, IET Systems Biology, Industrial & Engineering Chemistry Research, Reliability Engineering & System Safety, PLoS Computational Biology, Statistics and Computing, Water Research, Physical Biology, Journal of Biological Rhythms.

CONICYT reviewer for FONDEF, FONDECYT and FONDEQUIP grants.

Jan 2019-Dec 2020: Member of the “Engineering 2” Fondecyt study group.
Jan 2021-Present: Director of the “Engineering 2” Fondecyt study group.


Premios y Distinciones

  •   Extraordinary doctorate award

    UNIVERSIDAD DE VIGO

    España, 2007

    “Premio extraordinario de doctorado” (top prize for doctoral dissertations in the Spanish universities)

  •   Premio de Reconocimiento a la Excelencia Docente

    PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

    Chile, 2021

    El Premio de Reconocimiento a la Excelencia Docente es una iniciativa que reconoce y valora a integrantes del cuerpo académicos de la UC, que realizan un trabajo docente de excelencia, cumpliendo con la misión de la universidad de formar profesionales de calidad. El Premio busca destacar a quienes realizan una docencia de excelencia destacándose en el logro de todos los Principios Orientadores para una Docencia de Calidad UC.


 

Article (35)

Alternative language paradigms for functional magnetic resonance imaging as presurgical tools for inducing crossed cerebro-cerebellar language activations in brain tumor patients
A case-control study of a combination of single nucleotide polymorphisms and clinical parameters to predict clinically relevant toxicity associated with fluoropyrimidine and platinum-based chemotherapy in gastric cancer
Circadian Phase Prediction From Non-Intrusive and Ambulatory Physiological Data
Circadian Rhythm of Blood Pressure of Dipper and Non-dipper Patients With Essential Hypertension: A Mathematical Modeling Approach
Comparison of a tonometric with an oscillometric blood pressure monitoring device over 24 hours of ambulatory use
Emotion Recognition from ECG Signals Using Wavelet Scattering and Machine Learning
Identification of Statin's Action in a Small Cohort of Patients with Major Depression
Multi-Objective Optimization for Personalized Prediction of Venous Thromboembolism in Ovarian Cancer Patients
Optimization of physicochemical properties of novel multiple nanoemulsion for complex food matrices through iterative mathematical modelling
Protein quantification by bicinchoninic acid (BCA) assay follows complex kinetics and can be performed at short incubation times
Spikes and Nets (S&N): A New Fast, Parallel Computing, Point Process Software for Multineuronal Discharge and Connectivity Analysis
Urinary sodium-to-potassium ratio and plasma renin and aldosterone concentrations in normotensive children: implications for the interpretation of results
Acute Cardiovascular Responses to a Session of Bikram Yoga: A Pilot Uncontrolled Trial
Chilean Gastric Cancer Task Force A study protocol to obtain a clinical and molecular classification of a cohort of gastric cancer patients
Editor's Highlight: Differential Effects of Exposure to Single Versus a Mixture of Endocrine-Disrupting Chemicals on Steroidogenesis Pathway in Mouse Testes
Modeling the inflammatory response in the hypothalamus ensuing heat stroke: Iterative cycle of model calibration, identifiability analysis, experimental design and data collection
Systems biology approach to understanding post-traumatic stress disorder
Dynamics of an Interactive Network Composed of a Bacterial Two-Component System, a Transporter and K+ as Mediator
Quantity and accessibility for specific targeting of receptors in tumours
The hypothalamic-pituitary-adrenal-leptin axis and metabolic health: a systems approach to resilience, robustness and control
Attenuated thermoregulatory, metabolic, and liver acute phase protein response to heat stroke in TNF receptor knockout mice
Modeling the Intra- and Extracellular Cytokine Signaling Pathway under Heat Stroke in the Liver
Simultaneous model discrimination and parameter estimation in dynamic models of cellular systems
A Detailed Modular Analysis of Heat-Shock Protein Dynamics under Acute and Chronic Stress and Its Implication in Anxiety Disorders
Modeling Cortisol Dynamics in the Neuro-endocrine Axis Distinguishes Normal, Depression, and Post-traumatic Stress Disorder (PTSD) in Humans
Novel global sensitivity analysis methodology accounting for the crucial role of the distribution of input parameters: application to systems biology models
Detailed kinetic model describing new oligosaccharides synthesis using different beta-galactosidases
SensSB: a software toolbox for the development and sensitivity analysis of systems biology models
Vulnerabilities in the Tau Network and the Role of Ultrasensitive Points in Tau Pathophysiology
Monte Carlo evaluation of derivative-based global sensitivity measures
Identifiability and robust parameter estimation in food process modeling: Application to a drying model
Optimal design of dynamic experiments for improved estimation of kinetic parameters of thermal degradation
Scatter search for chemical and bio-process optimization
A hybrid approach for efficient and robust parameter estimation in biochemical pathways
Novel metaheuristic for parameter estimation in nonlinear dynamic biological systems

BookSection (2)

Optimal Experiment Design, Multimodality
Systems Biology

ConferencePaper (4)

Institute for Biological and Medical Engineering: From Molecules to Organisms with an Engineering Perspective
Unraveling the Cognitive Mechanism of Brain Self-Regulation Learning through Dynamic Mathematical Modeling
A personalized medicine approach to subtype identification in obesity: are circadian leptin-cortisol interactions a vulnerability factor?
Distinguishing normal, depressive and PTSD cortisol dynamics in humans through mathematical modelling

Proyecto (12)

Cyber-physical systems for personalized healthcare: a data-driven approach for improved management of diabetes and hypertension
Millennium Institute for Intelligent Healthcare Engineering
A Multi-Variable IoT-Ready Artificial Pancreas for Type 1 Diabetes Control
Lipophilic statins inhibit the exosome-mediated and obesity-induced cancer progression: the relevance of reestablishing natural killer cell immune surveillance to delay recurrence and improve future therapeutic outcomes in high-grade serous ovarian cancer
Vigilancia activa en cáncer de próstata: efectividad de la firma de cuatro ARNs largos no codificantes como marcador tisular de pronóstico tumoral
Neural Mechanisms of Brain Self-regulation with Brain-Machine Interfaces and Application to Addiction
Understanding the Circadian Rhythms of Blood Pressure in Humans through Mathematical Modeling and Computational Tools
Modeling the Intra and Extracellular Cytokine Signaling Pathway under Heat Stroke
SysMo-KOSMOBAC=> Ion and solute homeostasis in enteric bacteria=> an integrated view generated from the interface of modelling and biological experimentation
Application of global sensitivity analysis for complexity reduction, parameter estimation and time series forecasting
Nuevos métodos para la modelización y diseño de procesos térmicos emergentes en tecnología de alimentos=> modelización (MODISTER)
Conservación de alimentos=> nuevas metodologías y herramientas avanzadas para su simulación, optimización y control (CALISO)
46
María Rodríguez

Profesora Asociada

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

Santiago, Chile

3
Javiera Cortés

Estudiante de Doctorado

Instituto de Ingeniería Biológica y Médica

Pontificia Universidad Católica de Chile

Santiago, Chile

2
Gareth Owen

Profesor Titular

Fisiologia

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

1
María Maturana

Bioquimico

Pontificia Universidad Católica de Chile

Santiago, Chile

1
Camilo López

prof. Asociado

Química Física

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

1
Margarita Aliaga

Associate Professor

Química Física

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

1
Antonio Eblen

Profesor carga completa

Facultad de Medicina

Universidad Diego Portales

Santiago, Chile

1
RICARDO MORENO

Profesor Titular

Fisiología

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE, FACULTAD DE CIENCIAS BIOLÓGICAS, DEPTO. DE FISIOLOGÍA

Santiago, Chile

1
FERNANDO CROVARI

Jefe Departamento

Cirugía Digestiva

Pontificia Universidad Católica de Chile

Santiago, Chile

1
Cesar Sanchez

Profesor asistente

Hematologia-oncologia

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

santiago, Chile

1
José González

Profesor asistente

Facultad de Química

Pontificia Universidad Católica de Chile

Santiago, Chile

1
Rayen Valdivia

Estudiante de doctorado

Instituto de ingeniería biológica y médica

Pontificia Universidad Católica de Chile

santiago, Chile

1
Felipe Núñez

Associate Professor

Electrical Engineering

Pontificia Universidad Catolica de Chile

Santiago, Chile

1
Miguel Cordova

Estudiando de Doctorado

Departamento de Posgrado

Universidad de Chile

Santiago, Chile

1
Rene Baudrand

Profesor Asociado

Endocrinología

Pontificia Universidad Católica de Chile

Santiago, Chile

1
Fidel Allende

Quimico

Laboratorios Clinicos

Pontificia Universidad Católica de Chile

Santiago, Chile

1
Sandra Solari

Profesor Asociado

Departamento Laboratorios Clinicos - Facultad de Medicina - PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

1
Cristian Carvajal

Associate Professor

Endocrinologia

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

1
Helena Poggi

Coordinadora de Investiagción

División de Pediatría

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

1
Francisco Acevedo

Medico Oncologo

Hemato Oncologia

Pontificia Universidad Católica de Chile

Santiago, Chile

1
Carolina Mendez

Assistant Professor

Health Sciences

Pontificia Universidad Católica de Chile

Santiago, Chile

1
Ricardo Armisen

Associate Professor

Centro de Genética y Genómica

Universidad del Desarrollo

Santiago, Chile

1
Marcelo Garrido

Director

CENTRO DEL CÁNCER, PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

1
Manuel Espinoza

Profesor Asociado

Salud Pública

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

Santiago, Chile

1
Ignacio Retamal

Docente

Universidad de Los Andes

Santiago, Chile