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Javiera Alejandra Cortés Ríos

Estudiante de Doctorado

Pontificia Universidad Católica de Chile

Santiago, Chile

Mis líneas de investigación incluyen modelamiento matemático de sistemas biológicos, bioquímica enzimática y biología redox para estudiar mecanismos de regulación y efectos de fármacos, con un enfoque computacional y aplicaciones traslacionales.

Química Farmacéutica, UNIVERSIDAD DE CHILE. Chile, 2018
Ciencias Farmacéuticas, UNIVERSIDAD DE CHILE. Chile, 2016
Ciencias de la Ingeniería, PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE. Chile, 2023

UB/GSK Postdoctoral Fellow Full Time

STATE UNIVERSITY OF NEY YORK AT BUFFALO

Buffalo, Estados Unidos

2023 - A la fecha
Postdoctoral Researcher Full Time

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

Institute for Biological and Medical Engineering

Santiago, Chile

2023 - 2023
Research Asistant Part Time

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

Institute for Biological and Medical Engineering

Chile

2018 - 2019
Research Asistant Part Time

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

Facultad de Química y de Farmacia

Chile

2018 - 2019
Graduate Student Intern Full Time

HARVARD UNIVERSITY

Boston, Estados Unidos

2022 - 2022
Postdoctoral Fellow Intern Full Time

GlaxoSmithKline

Cambridge, Estados Unidos

2024 - 2024

Químico Farmacéutico Part Time

Salcobrand

Chile

2018 - 2019

Quantitative Systems Pharmacology SIG Trainee Award

International Society of Pharmacometrics (ISoP)

Estados Unidos, 2024

Trainee award for the poster “Novel Computational Workflow for Selecting Virtual Patient Cohorts for In Silico Clinical Trials”.
3rd place Poster Award

ASPET 2021 Annual Meeting at Experimental Biology

Chile, 2021

3rd place Poster Award for the work entitled “Dosing Time Optimization of Enalapril and Propranolol through Inclusion of the Circadian Rhythm in Pharmacokinetic-Pharmacodynamic Modeling”, Division for Translational and Clinical Pharmacology
1st place Poster Award

UNIVERSIDAD DE CHILE

Chile, 2018

1st place Poster Award for the work entitled “Mathematical Modeling of the Circadian Rhythm of Blood Pressure in Humans”, Women in Science Meeting: Breaking Down Myths and Barriers, Universidad de Chile.


Dynamic modeling of cell cycle arrest through integrated single-cell and mathematical modelling approaches Cortés-Ríos, Javiera; Rodriguez-Fernandez, Maria; Sorger, Peter K.; Fröhlich, Fabian Article PMID: 40060624, PMCID: PMC11888159. WOSUID: MEDLINE:40060624 bioRxiv (2025)
COMPETITIVE OXIDATION OF ENZYMES OF THE PENTOSE PHOSPHATE PATHWAY, MEDIATED BY PEROXYL RADICALS, AFFECTS FUNCTIONALITY OF THE PATHWAY TO PRODUCE NADPH Sebastian Reyes, Juan; Cortés-Ríos, Javiera; Fuentes-Lemus, Eduardo; Rodriguez-Fernandez, Maria; Davies, Michael J.; Lopez-Alarcon, Camilo Article ISI FREE RADICAL BIOLOGY AND MEDICINE (2024)
Competitive oxidation of key pentose phosphate pathway enzymes modulates the fate of intermediates and NAPDH production Article ISI FREE RADICAL BIOLOGY AND MEDICINE (2024)
The competitive oxidation of key enzymes of the pentose phosphate pathway by peroxyl radicals modulates NADPH production Sebastian Reyes, Juan; Fuentes-Lemus, Eduardo; Cortés-Ríos, Javiera; Rodriguez, Maria; Davies, Michael; Lopez, Camilo Article ISI FREE RADICAL BIOLOGY AND MEDICINE (2023)
Understanding the dosing-time-dependent antihypertensive effect of valsartan and aspirin through mathematical modeling Article ISI FRONTIERS IN ENDOCRINOLOGY (2023)
Dosing time optimization of antihypertensive medications by including the circadian rhythm in pharmacokinetic-pharmacodynamic models Hermida, Ramon C. Article ISI PLOS COMPUTATIONAL BIOLOGY (2022)
Circadian Rhythm of Blood Pressure of Dipper and Non-dipper Patients With Essential Hypertension: A Mathematical Modeling Approach Article ISI Frontiers in Physiology (2021)
Dosing Time Optimization of Enalapril and Propranolol through Inclusion of the Circadian Rhythm in Pharmacokinetic-Pharmacodynamic Modeling Cortes, Javiera; Rodriguez, Maria Article ISI FASEB JOURNAL (2021)
Nitrofuran drugs beyond redox cycling: Evidence of Nitroreduction-independent cytotoxicity mechanism Article ISI TOXICOLOGY AND APPLIED PHARMACOLOGY (2020)
Optimization of physicochemical properties of novel multiple nanoemulsion for complex food matrices through iterative mathematical modelling Valdivia-Olivares R.Y. Article ISI SCOPUS (2020)
Protein quantification by bicinchoninic acid (BCA) assay follows complex kinetics and can be performed at short incubation times Aliaga, Margarita Article ISI ANALYTICAL BIOCHEMISTRY (2020)
Quantification of carbonate radical formation by the bicarbonate-dependent peroxidase activity of superoxide dismutase 1 using pyrogallol red bleaching David Figueroa, Juan; Dorta, Eva; Cortés-Ríos, Javiera; Faúndez, Mario; Contreras, David; Denicola, Ana; Alvarez, Beatriz Article ISI SCOPUS REDOX BIOLOGY (2019)
NADPH oxidase activity: Spectrophotometric determination of superoxide using pyrogallol red Cortés-Ríos, J; Campos-Bustamante M.P. Article ISI SCOPUS ANALYTICAL BIOCHEMISTRY (2017)


Use of pyrogallol red to assess carbonate anion radical formation from the bicarbonate-dependent peroxidase activity of superoxide dismutase 1 Figueroa-Alegria, JD Abstract ISI (2018)


Integrating mathematical modeling with multiplexed immunofluorescence data to predict drug-induced cell arrest Cortés-Ríos, Javiera; Rodriguez-Fernandez, Maria; Sorger, Peter K.; Fröhlich, Fabian ConferencePoster (2024)
Leveraging in silico clinical trials based on the Everest study to obtain mechanistic insights into determinants of functional cure with standard-of-care therapies in chronically infected HBV patients Cortés-Ríos, Javiera; Ren, Tianjing; Hanan, Nathan; Sher, Anna; Nader, Ahmed; Magee, Mindy; Jusko, William J.; Desikan, Rajat ConferencePoster (2024)
Novel computational workflow for selecting virtual patient cohorts for in silico clinical trials Cortés-Ríos, Javiera; Whittaker, Dominic G.; Nader, Ahmed; Sher, Anna; Jusko, William J.; Desikan, Rajat ConferencePoster (2024)
Design and optimization of nanosystems for drugs with poor biopharmaceutical properties through mathematical modeling Valdivia-Olivares, Rayen V.; Cortés-Ríos, Javiera; Álvarez-Figueroa, Maria J.; Rodriguez-Fernandez, Maria; González-Aramundiz, José V. ConferencePoster (2022)
Optimization of the dosing time of antihypertensive medication through pharmacokinetic-pharmacodynamic models Cortés-Ríos, Javiera; Hermida, Ramon; Rodriguez-Fernandez, Maria ConferencePoster (2022)
Using mathematical modeling to understand the time-dependent antihypertensive effect of aspirin Cortés-Ríos, Javiera; Rodriguez-Fernandez, Maria ConferencePoster (2022)
Understanding overflow metabolism in E. coli through the inclusion of enzymatic constraints Cortés-Ríos, Javiera; Leiva-Guerra, Ricardo; Acuña-Benavides, Cain; Rodriguez-Fernandez, Maria; Saa, Pedro ConferencePoster (2021)
Understanding the time-dependent antihypertensive effect of valsartan through mathematical modeling Cortés-Ríos, Javiera; Rodriguez-Fernandez, Maria ConferencePoster (2021)
NADPH oxidase activity: spectrophotometric determination of superoxide using pyrogallol red. Cortés-Ríos, Javiera; Torres, Maria J.; Campos-Bustamante, Maria P.; Romero-Parra, Javier; Letelier, Maria E.; Pessoa-Mahana, D.; Chung, H.; Faúndez, Mario ConferencePoster (2017)


Cyber-physical systems for personalized healthcare: a data-driven approach for improved management of diabetes and hypertension PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE Proyecto (2021)
Oxidative modifications induced by carbonate radical, nitrogen dioxide, and peroxyl radicals on two enzymes of the pentose phosphate pathway: consequences on NADPH release and reduced glutathione recycling Lopez, Camilo; PONTIFICIA UNIVERSIDAD CATOLICA DE VALPARAISO Proyecto (2018)
Understanding the Circadian Rhythms of Blood Pressure in Humans through Mathematical Modeling and Computational Tools FONDECYT (1181094) Proyecto 2018-2020 Personal técnico y/o de apoyo