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Camilo Ignacio López Alarcón

prof. Asociado

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

Líneas de Investigación


Radicales Libres, Proteínas, Péptidos, antioxidantes

Educación

  •  Química, UNIVERSIDAD DE CHILE. Chile, 2004

Experiencia Académica

  •   prof. Asociado Full Time

    PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

    Química

    Santiago, Chile

    2005 - 2018

  •   Profesor Titular Full Time

    PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

    Chile

    2018 - A la fecha

Formación de Capital Humano


DOCTORATE SUPERVISOR
2013
Dr. Andrea Arenas, thesis: Evaluation of the oxidative damage induced by hydrosoluble peroxyl radicals on proteins of the ocular globe.
Doctorate in Chemistry, Pontificia Universidad Católica de Chile

2014
Dr. Elías Atala, thesis: Interaction of phenols and polyphenols with reactive species in acidic medium: a competitive kinetic study.
Doctorate in Chemistry, Pontificia Universidad Católica de Chile

2014
Dr. Julie Benavides, thesis: Interaction of hypochlorous acid and monochloramine with omeprazole, tetracycline and polyphenols.
Doctorate in Chemistry, Pontificia Universidad Católica de Chile

2015
Dr. Jael Reyes, thesis: Reaction of phenols towards nitrous acida: nitric oxide generation and possible role of nitrogen dioxide.
Doctorate in Chemistry, Pontificia Universidad Católica de Chile

Current PhD students
2015
Eduardo Fuentes: Oxidative processes of bovine milk proteins induced by peroxyl radicals: potential protective role of polyphenols.
Doctorate in Chemistry, Pontificia Universidad Católica de Chile

2014
Elizabeth Escobar: Role of aromatic amino-acids on the crosslinking and fragmentation processes of peptides and proteins mediated by alkyl and peroxyl radicals. Doctorate in Chemistry, Pontificia Universidad Católica de Chile

2017
Limberg Jaldin. Doctorate in Chemistry, Pontificia Universidad Católica de Chile

POSTDOCTORATE ADVISOR

Dra. Eva Dorta (FONDECYT nº 3140307).
Study of the oxidative damage on myofibrillar proteins mediated by hydrosoluble peroxyl radicals: tole of polyphenols obtained from peel and seed of mango (Mangifera Indica L.) as potential antioxidant compounds Pontificia Universidad Católica de Chile

UNDERGRADUATE SUPERVISOR

2008
Carolina Rojo Vergara (Co-director): Interaction of diclofenac with peroxyl radicals, influence on its passage through the skin.
Pharmacist, Pontificia Universidad Católica de Chile
Ivonne Martin Caruti (Director): Development and application of a new method to evaluate the antioxidant capacity of phenols and polyphenols.
Pharmacist, Pontificia Universidad Católica de Chile
Paula Torres Olivares (Director): Application of a new ORAC assay to evaluate ascorbic acid in human plasma.
Pharmacist, Pontificia Universidad Católica de Chile
Evelyn Mura Martínez (Director): Application of a new ORAC method to evaluate the antioxidant capacity of wines.
Pharmacist, Pontificia Universidad Católica de Chile
Felipe Duffe Pino (Director): Study of the interaction of antioxidants with a stable free radical in biodegradable polymeric micelles.
Pharmacist, Pontificia Universidad Católica de Chile
Paula Galleguillos Bustamante (Director): Application of a new ORAC method to evaluate ascorbic acid in human urine.
Pharmacist, Pontificia Universidad Católica de Chile

2009
Valeria Inostroza Guichonet (Director): Use of asthaxantin and Carotene to evaluate the antioxidant activity of oils throughout a new ORAC assay.
Pharmacist, Pontificia Universidad Católica de Chile

2011
Daniela Vásquez Mera (Director): Trapping of free radicals derived from amino acids using pre-fluorescent probes.
Pharmacist, Pontificia Universidad Católica de Chile
Fabiola Betancourt Lagos (Director): Pyrogallol red and 5-aminosalicilic acid: possible target molecules for a new ORAC assay towards nitrite in acidic medium.
Pharmacist, Pontificia Universidad Católica de Chile
Franco Colonelli Jeria (Director): Effect of linoleic acid in the antioxidant activity of nitroxides in neutral micelles.
Pharmacist, Pontificia Universidad Católica de Chile
Elisa Montupil Vega (Director): Spectroscopic and chromatographic study of the reaction between pyrogallol red and nitrous acid.
Pharmacist, Pontificia Universidad Católica de Chile
Max Romero Garate (Director): Effect of the compartmentalized medium on the ORAC-PGR index.
Pharmacist, Pontificia Universidad Católica de Chile

2012
Constanza Cortes Atuán (Co-director): A new method to estimate the antioxidant capacity of vegetable extracts based on the interaction of pyranine with nitrous acid. Pharmacist, Pontificia Universidad Católica de Chile
Daniel Fuentes Aravena (Director): Interaction of flavonoids with peroxyl radicals, kinetic behavior and antioxidant capacity.
Pharmacist, Pontificia Universidad Católica de Chile
César Segovia Miranda (Co-director): Nanoparticles: Interaction with free radicals.
Pharmacist, Pontificia Universidad Católica de Chile

2013
Verónica Tapia Zúñiga (Director): Interaction of pyrogallol red with superoxide. Evaluation of the antioxidant capacity of human plasma.
Pharmacist, Pontificia Universidad Católica de Chile
María Jesús Troncoso (Director): Use of the polyvinilpolipirrolidone (PVPP) for evaluating the total content of phenols in complex mixtures throughout the Folin-Ciocalteu assay. Pharmacist, Pontificia Universidad Católica de Chile
Rocío Ortíz Mercado (Director): Effect of hydrosoluble peroxyl radicals on the enzymatic activity of ?-glucosidases.
Pharmacist, Pontificia Universidad Católica de Chile
Sergio Lobato Gutiérrez (Director): Antioxidant activity of chilean red wines: application of the ORAC (Oxygen Radical Absorbance Capacity) methodology. Pharmacist, Pontificia Universidad Católica de Chile
Nelson Piro Mesina (Director): Interaction of gallic acid and esters with hypochlorite and n-chlorobutilamine: influence of a compartmentalized system. Pharmacist, Pontificia Universidad Católica de Chile
María Fernanda Morán (Co-director): Analysis of the antioxidant activity of propolis produced in the VI region, Chile.
Pharmacist, Pontificia Universidad Católica de Chile
Denisse Ovalle Jimenez (Patrocinante): Formation and implementation of a repository to the regulatory department of GlaxoSmithKline.
Pharmacist, Pontificia Universidad Católica de Chile

2014
Isaac Jara Pezoa (Co-director): Determination of the phenolic composition of propolis from VI region, Chile and their capacity to generate nitric oxide.
Pharmacist, Pontificia Universidad Católica de Chile
Claudio Villagra Soto (Co-director): Influence of cholesterol in the peroxidation of lipid vesicles containing pyrogallol red.
Pharmacist, Pontificia Universidad Católica de Chile
Romina Díaz Mosquera (Patrocinante): Study of the correlation between satisfaction of the medical consultation and the adherence to the therapy in patients with arterial hypertension. Pharmacist, Pontificia Universidad Católica de Chile
Eduardo Fuentes Lemus (Director): Consumption of tryptophan free and included in Consumo de triptófano libre e incluido en peptides mediated by peroxyl radicals: a kinetic study. Pharmacist, Pontificia Universidad Católica de Chile


Difusión y Transferencia


CONFERENCES

Nov-2015 Society for Redox Biology and Medicine’s Annual Meeting, Boston, USA. A kinetic study of the free, peptide-included and protein-included tryptophan oxidation. E. Fuentes-Lemus, E. Dorta, M.L. Abasq, H. Speisky, E. Silva, E. Lissi, C. López-Alarcón.*

Sept-2014 Meeting of the Society Free Radical Research International (SFRR-E 2014). Paris, France. A kinetic study of tryptophan consumption mediated by peroxyl radicals: effect of its inclusion in di and tri-peptides.E. Fuentes, E. Lissi, C. López-Alarcón.*

Sept-2014 Meeting of the Society Free Radical Research International (SFRR-E 2014). Paris, France. Role of alkoxyl radicals on the fluorescein-based ORAC (Oxygen Radical Absorbance Capacity) assay. E. Dorta, E. Atala, A. Aspée, H. Speisky, E. Lissi, C. López-Alarcón.*

Oct-2013 VIII Meeting of the Society Free Radical Biology and Medicine-South American Group. A pyrogallol red-based ORAC (Oxygen Radical Absorbance Capacity) assay to evaluate antioxidant capacity of phenols in acidic medium. E. Atala, A. Aspee, H. Speisky, E. Lissi, C. López-Alarcón.

Sep.- 2012 16th biennial meeting for the Society for Free Radical Research International. Imperial College of London, UK. Bleaching of the Pyrogallol Red dye induced by superoxide anion radical: Application to study redox cycling reactions of nitrocompounds. C. López-Alarcón, H. Speisky, M. Aliaga, E. Lissi, M. Rojas, M. Faúndez.

Oct.-2011 5th International Conference on Polyphenols and Health (ICPH). Sitges, Barcelona, Spain. Interaction of pyrogallol red with hypoclorite and nitrous acid: evaluation of the antioxidant activity of pure polyphenols and their complex mixtures. C. López-Alarcón, F. Pérez-Cruz, C. Olea-Azar, E. Atala, P. Bohle, E. Lissi.

Dec.-2010 First Symposium of Free Radicals and Antioxidants. Valparaíso, Chile. In vitro evaluation of antioxidant capacity: a critical analysis. C. López-Alarcón.

Jul.-2009 Organic Free Radicals. Ottawa, Canada. Antioxidant reactivity toward nitroxides anchored in human serum albumin. A. Aspée, A. Orrego, E. Alarcón, C. López-Alarcón, H. Poblete, D. Gonzalez-Nilo.

Nov.-2008 IX Encontro Latino-Americano de Fotoquímica e Fotobiología (ELAFOT 2008). Cubatão/Santos, SP, Brazil. Determination of rate constant reactions of hydroxycinnamic acids with pyranine derived radicals by laser flash photolysis. Alexis Aspée, Luca Maretti, Gabriela Velasquez, J.C. Scaiano, Camilo López-Alarcón.

Jul.-2008 19th IUPAC Conference on Physical Organic Chemistry. Santiago de Compostela, Spain. Kinetic Study of the generation of superoxide radicals during the reaction between Cu(I)-glutathione and molecular oxygen. Margarita Aliaga, Catalina Carrasco-Pozo, Francesca Burgos, Camilo López-Alarcón, Hernán Speisky.

Oct.-2007 9th Latin American Conference on Physical Organic Chemistry. Córdoba, Argentina. Repair process in free radical reactions. E. Lissi, A. Aspée, C. Aliaga, C. López-Alarcón.

Oct.-2007 9th Latin American Conference on Physical Organic Chemistry. Córdoba, Argentina. Influence of the target molecule on the oxygen radical absorbance capacity (ORAC) index. C. López-Alarcón, I. Martin, E. Lissi.

Sep.-2007 V Meeting of Society of Free Radical Biology Medicine – South American Group. V International Conference on Peroxynitrite and Reactive Nitrogen Species. Montevideo, Uruguay. ORAC-Pyrogallol red: Evaluation of polyphenols reactivity and ascorbic acid determination in fruit extracts. C. López-Alarcón, E. Atala, H. Speisky, E. Lissi.

Jan.-2006 XXVI Congress of the Chilean Chemical Society. Concepción, Chile. “Kinetic study of the secondary reactivity of flavonoids and related polyphenols”. C. López-Alarcón, E. Lissi.

Jan.-2006 XXVI Congress of the Chilean Chemical Society. Concepción, Chile. “A novel and simple ORAC methodology based on the interaction of pyrogallol red with peroxyl radicals”. C. López-Alarcón, E. Lissi.

Sept.-2004 55 th ISE Meeting. Thessaloniki, Greece. “Electro-oxidation of 1,4-dihydropyridines and its reactivity with alkylperoxyl radicals”. L.J. Núñez-Vergara., C. López-Alarcón, J.A. Squella.

Feb.-2004 XVI Congress of the Iberoamerican Electrochemical Society (SIBAE). San José, Costa Rica. "Electro-oxidation of 1,4-dihydropyridines in aqueous medium”. C. López-Alarcón, L.J. Núñez-Vergara, J.A. Squella.

Sept.- 2003 54 th ISE Meeting. Sao Pedro, Brazil. “Voltammetric oxidation of Hantzsch 1,4-dihydropyridines in protic and aprotic media: relevance of the substitution on N position”. J. A. Squella , C. López-Alarcón, L.J. Núñez-Vergara.

Sept.-2002 XV Congress of the Iberoamerican Electrochemical Society (SIBAE). Évora, Portugal. "electrochemical oxidation of new 1,4-dihydropyridines: a GC-MS study ". L.J. Núñez-Vergara, C. López-Alarcón, C. Camargo, J.A. Squella.

Nov.-2001 XXIV Congress of the Chilean Chemical Society. Temuco, Chile. “Electro-oxidation of 1,4-DHP-4-sustituides in acetronitrile". L.J. Núñez-Vergara, C. López-Alarcón, P. Navarrete, A.M. Atria, J.A. Squella.

May.-2000 XIV Congress of the Iberoamerican Electrochemical Society (SIBAE). Oaxaca, México. “A voltammetric method to study 1,4-dihydropyridine degradation”. C. López-Alarcón, L.J. Núñez-Vergara, J.A. Squella.

Jul.-1998 XXIII Latinoamerican Congress of Chemistry. Río Grande, Puerto Rico. Lomefloxacin: voltammetric behaviour and electroanalytical applications”, A. Álvarez-Lueje, C. López, L.J. Núñez-Vergara, J.A. Squella.

ORAL PRESENTATIONS

-“Invited speaker” National Meeting & Exposition of the American Chemical Society. Boston, fall-2010.
-Conference at University of Rennes 1, Rennes, France. October, 2014.
-Conference at University of Rennes 1, Rennes, France. June, 2017.
-Conference at University of Greifswald, Germany. June, 2017.
-14th Latino American Conference on Physical Organic Chemistry (CLAFQO-14), May 2017, Concon, Chile.


Premios y Distinciones

  •   Recognition to the research trajectory (FONDECYT)

    FONDECYT

    Chile, 2012

    Reconocimiento a la trayectoria en Investigación Fondecyt


 

Article (103)

M. jannaschii FtsZ, a key protein in bacterial cell division, is inactivated by peroxyl radical-mediated methionine oxidation
Oxidation of lysozyme induced by peroxyl radicals involves amino acid modifications, loss of activity, and formation of specific crosslinks
Azocompounds as generators of defined radical species: Contributions and challenges for free radical research
Formation and characterization of crosslinks, including Tyr-Trp species, on one electron oxidation of free Tyr and Trp residues by carbonate radical anion
Free radicals derived from ?-radiolysis of water and AAPH thermolysis mediate oxidative crosslinking of eGFP involving Tyr-Tyr and Tyr-Cys bonds: the fluorescence of the protein is conserved only towards peroxyl radicals
Photo-induced protein oxidation: mechanisms, consequences and medical applications
Photo-oxidation of lysozyme triggered by riboflavin is O2-dependent, occurs via mixed type 1 and type 2 pathways, and results in inactivation, site-specific damage and intra- and inter-molecular crosslinks
Protein quantification by bicinchoninic acid (BCA) assay follows complex kinetics and can be performed at short incubation times
Binding of rose bengal to lysozyme modulates photooxidation and cross-linking reactions involving tyrosine and tryptophan
Immobilization of Andean berry (Vaccinium meridionale) polyphenols on nanocellulose isolated from banana residues: A natural food additive with antioxidant properties
Oxidation of myofibrillar proteins induced by peroxyl radicals: Role of oxidizable amino acids
Quantification of carbonate radical formation by the bicarbonate-dependent peroxidase activity of superoxide dismutase 1 using pyrogallol red bleaching
Riboflavin-induced Type 1 photo-oxidation of tryptophan using a high intensity 365 nm light emitting diode
Aggregation of alpha- and beta- caseins induced by peroxyl radicals involves secondary reactions of carbonyl compounds as well as di-tyrosine and di-tryptophan formation
alpha- and beta-casein aggregation induced by riboflavin-sensitized photo-oxidation occurs via di-tyrosine cross-links and is oxygen concentration dependent
Atypical antioxidant activity of non-phenolic amino-coumarins
Evaluation of the antioxidant capacity of food samples=> a chemical examination of the oxygen radical absorbance capacity assay
Superoxide radicals react with peptide-derived tryptophan radicals with very high rate constants to give hydroperoxides as major products
Controversial alkoxyl and peroxyl radical scavenging activity of the tryptophan metabolite 3-hydroxy-anthranilic acid
Cytoprotective Mechanisms Mediated by Polyphenols from Chilean Native Berries against Free Radical-Induced Damage on AGS Cells
Formation and detection of oxidant-generated tryptophan dimers in peptides and proteins
Kinetics of the Anaerobic Reaction of para-Substituted Phenols with Nitrogen Dioxide
Oxidative stabilization of palm olein with isoespintanol (2-isopropyl-3,6-dimethoxy-5-methylphenol) isolated from Oxandra cf xylopioides
Peroxyl radical- and photo-oxidation of glucose 6-phosphate dehydrogenase generates cross-links and functional changes via oxidation of tyrosine and tryptophan residues
Reaction Kinetics of Phenolic Antioxidants toward Photoinduced Pyranine Free Radicals in Biological Models
Reaction of tetracycline with biologically relevant chloramines
The peroxyl radical-induced oxidation of Escherichia coli FtsZ and its single tryptophan mutant (Y222W) modifies specific side-chains, generates protein cross-links and affects biological function
Use of the Oxygen Radical Absorbance Capacity (ORAC) Assay to Predict the Capacity of Mango (Mangifera indica L.) By-Products to Inhibit Meat Protein Oxidation
Comparison of different techniques for the preservation and extraction of phlorotannins in the kelp Lessonia spicata (Phaeophyceae): assays of DPPH, ORAC-PGR, and ORAC-FL as testing methods
Oxidation of free, peptide and protein tryptophan residues mediated by AAPH-derived free radicals: Role of alkoxyl and peroxyl radicals
Redox-implications associated with the formation of complexes between copper ions and reduced or oxidized glutathione
International Regulations of Propolis Quality: Required Assays do not Necessarily Reflect their Polyphenolic-Related In Vitro Activities
Kinetics of the Reaction of Pyrogallol Red, a Polyphenolic Dye, with Nitrous Acid: Role of center dot NO and center dot NO2
Monitoring peroxides generation during model wine fermentation by FOX-1 assay
The ORAC (oxygen radical absorbance capacity) index does not reflect the capacity of antioxidants to trap peroxyl radicals
A Polyvinylpolypyrrolidone (PVPP)-Assisted Folin-Ciocalteu Assay to Assess Total Phenol Content of Commercial Beverages
Effects of Aging on the Antioxidant Capacity of Red Wines
Influence of the growing region, quality classification and harvest year on the ORAC (Oxygen Radical Absorbance Capacity) index of Chilean Cabernet Sauvignon red wines
Reactions of p-Substituted Phenols with Nitrous Acid in Aqueous Solution
Anti-Peroxyl Radical Quality and Antibacterial Properties of Rooibos Infusions and Their Pure Glycosylated Polyphenolic Constituents
Antioxidant capacity of phenolic compounds in acidic medium: A pyrogallol red-based ORAC (oxygen radical absorbance capacity) assay
Chemical Modification of Lysozyme, Glucose 6-Phosphate Dehydrogenase, and Bovine Eye Lens Proteins Induced by Peroxyl Radicals: Role of Oxidizable Amino Acid Residues
Cu(II)-disulfide complexes display simultaneous superoxide dismutase- and catalase-like activities
EVALUATION OF THE TOTAL AMOUNT OF PHENOL GROUPS IN COMPLEX MIXTURES BY FOLIN'S AND ORAC-FLUORESCEIN METHODOLOGIES
Mechanism of Pyrogallol Red Oxidation Induced by Free Radicals and Reactive Oxidant Species. A Kinetic and Spectroelectrochemistry Study
Selected hydroxycoumarins as antioxidants in cells: physicochemical and reactive oxygen species scavenging studies
Use of Pyrogallol Red and Pyranine as Probes to Evaluate Antioxidant Capacities towards Hypochlorite
Application of a microplate-based orac-pyrogallol red assay for the estimation of antioxidant capacity: First action 2012.03
First Web-Based Database on Total Phenolics and Oxygen Radical Absorbance Capacity (ORAC) of Fruits Produced and Consumed within the South Andes Region of South America
Inhibition of mitochondrial complex I by various non-steroidal anti-inflammatory drugs and its protection by quercetin via a coenzyme Q-like action
KINETIC AND STOICHIOMETRIC EVALUATION OF FREE RADICALS SCAVENGERS ACTIVITIES BASED ON DIPHENYL-PICRYL HYDRAZYYL (DPPH) CONSUMPTION
Redox-changes associated with the glutathione-dependent ability of the Cu(II)-GSSG complex to generate superoxide
Analytical Parameters of the Microplate-Based ORAC-Pyrogallol Red Assay
Electrochemical and Spectroscopic Study of Pyranine Fluorescent Probe: Role of Intermediates in Pyranine Oxidation
Interaction of 5-aminosalicylic acid with nitrous acid: formation of the diazonium derivative and nitric oxide release
Oxidative Damage of Lysozyme and Human Serum Albumin and Their Mixtures. A Comparison of Photosensitized and Peroxyl Radical Promoted Processes
Pyrogallol red oxidation induced by superoxide radicals: Application to evaluate redox cycling of nitro compounds
Reaction of Diphenylpicrylhydrazyl (DPPH) with Antioxidants in Presence of Poly(epsilon-caprolactone)/Poly(N-vinyl-2-pyrrolidone) Block Copolymer Nanoaggregates
Role of Superoxide Anions in the Redox Changes Affecting the Physiologically Occurring Cu(I)-Glutathione Complex
Superoxide-dependent reduction of free Fe3+ and release of Fe2+ from ferritin by the physiologically-occurring Cu(I)-glutathione complex
Time-dependence of Ferric Reducing Antioxidant Power (FRAP) index in Chilean apples and berries
USE OF THE ORAC-PYROGALLOL RED/ORAC-FLUORESCEIN RATIO TO ASSESS THE QUALITY OF ANTIOXIDANTS IN CHILEAN WINES
Antioxidant Capacity of Pure Compounds and Complex Mixtures Evaluated by the ORAC-Pyrogallol Red Assay in the Presence of Triton X-100 Micelles
Influence of the target molecule on the ORAC index
Photophysical characterization of atorvastatin (Lipitor (R)) ortho-hydroxy metabolite: role of hydroxyl group on the drug photochemistry
Redox-active complexes formed during the interaction between glutathione and mercury and/or copper ions
The Cu(I)-glutathione complex: factors affecting its formation and capacity to generate reactive oxygen species
Antioxidant reactivity toward nitroxide probes anchored into human serum albumin. A new model for studying antioxidant repairing capacity of protein radicals
Ascorbic acid contribution to ORAC values in berry extracts: An evaluation by the ORAC-pyrogallol red methodology
Generation of superoxide radicals by copper-glutathione complexes: Redox-consequences associated with their interaction with reduced glutathione
Influence of the Target Molecule on the Oxygen Radical Absorbance Capacity Index: A Comparison Between Alizarin Red- and Fluorescein-Based Methodologies
OXYGEN RADICAL ANTIOXIDANT CAPACITY (ORAC) VALUES OF HERBAL TEAS OBTAINED EMPLOYING DIFFERENT METHODOLOGIES CAN PROVIDE COMPLEMENTARY DATA
RELEVANCE OF SECONDARY PROCESSES IN ORAC VALUES OBTAINED EMPLOYING PYROGALLOL RED AS TARGET MOLECULE
SCAVENGING ACTIVITY OF DICLOFENAC. INTERACTION WITH ABTS RADICAL CATION AND PEROXYL RADICALS
Transdermal penetration of diclofenac in the presence of AAPH-derived peroxyl radicals
ANTIOXIDANT ACTIVITY IN SOUTHERN BRAZIL HYPERICUM SPECIES
ANTIOXIDANT ACTIVITYIN SOUTHERN BRAZIL HYPERICUM SPECIES
Antioxidant capacity of herbal infusions and tea extracts: A comparison of ORAC-fluorescein and ORAC-pyrogallol red methodologies
Antioxidant capacity of human blood plasma and human urine: Simultaneous evaluation of the ORAC index and ascorbic acid concentration employing pyrogallol red as probe
Cu(I)-glutathione complex: A potential source of superoxide radicals generation
ANTIOXIDANT ACTIVITY OF FLAVONOIDS ISOLATED FROM HYPERICUM TERNUM
Antioxidant effect of 5-amino salicylic acid on copper-mediated LDL oxidation
Antioxidant reactivity evaluated by competitive kinetics: Influence of the target molecule concentration
Competitive kinetics in free radical reactions of cinnamic acid derivatives. Influence of phenoxyl radicals reactions
Generation, spectroscopic characterization by EPR, and decay of a pyranine-derived radical
Nitroaryl-1,4-dihydropyridines as antioxidants against rat liver microsomes oxidation induced by iron/ascorbate, Nitrofurantoin and naphthalene
A novel and simple ORAC methodology based on the interaction of Pyrogallol Red with peroxyl radicals
Antioxidant screening of medicinal herbal teas
Free radical scavenging capacity of hydroxycinnamic acids and related compounds
In vitro interaction between homocysteine and copper ions: Potential redox implications
Reactivity of hydroxynaphthalenes towards peroxyl radicals
Interaction and reactivity of urocanic acid towards peroxyl radicals
Interaction of pyrogallol red with peroxyl radicals. A basis for a simple methodology for the evaluation of antioxidant capabilities
Reaction of 5-aminosalicylic acid with peroxyl radicals: Protection and recovery by ascorbic acid and amino acids
1,4-Dihydropyridines: Reactivity of nitrosoaryl and nitroaryl derivatives with alkylperoxyl radicals and ABTS radical cation
Reactivity of 1,4-dihydropyridines toward SIN-1-derived peroxynitrite
Spectroelectrochemical study on the electrooxidation in aqueous medium of some 1,4-dihydropyridines: Effects of substitution in 1-position and 4-position
Structural effects on the reactivity 1,4-dihydropyridines with alkylperoxyl radicals and ABTS radical cation
Electrochemical and EPR characterization of 1,4-dihydropyridines. Reactivity towards alkyl radicals
Reactivity of 1,4-dihydropyridines toward alkyl, alkylperoxyl radicals, and ABTS radical cation
Voltammetric oxidation of Hantzsch 1,4-dihydropyridines in protic and aprotic media: relevance of the substitution on N position
Gas chromatography/mass spectrometric study of non-commercial C-4-substituted 1,4-dihydropyridines and their oxidized derivatives
Voltammetric behavior and analytical applications of lomefloxacin, an antibacterial fluorquinolone

Abstract (2)

Consumption of peptide-included and free tryptophan induced by peroxyl radicals: A kinetic study
Protective Effect of Synthetic Hydroxycoumarin Derivatives on Bovine Aortic Endothelial Cells Against Oxidative Stress Induced by 3-Morpholinosydnonimine and Hydrogen Peroxide

BookSection (1)

Generation of Superoxide by the Interaction between Mercury Ions and Endogenous Thiols

BookWhole (1)

Assessment of the antioxidant capacity of green teas: A critical review

ConferencePaper (1)

Reaction of diphenylpicrylhydrazyl (DPPH) with antioxidants in presence of poly(?-caprolactone)/poly(N-vinyl-2-pyrrolidone) block copolymer nanoaggregates

Proyecto (11)

Oxidative modifications induced by carbonate radical, nitrogen dioxide, and peroxyl radicals on two enzymes of the pentose phosphate pathway: consequences on NADPH release and reduced glutathione recycling
PHOTOINDUCED FREE RADICALS AND EXCITED TRIPLET STATES FORMATION IN ORGANIZED BIOLOGICAL MIMETIC SYSTEMS.
ROLE OF TRYTOPHAN RESIDUES IN THE AGGREGATION AND FRAGMENTATION OF PEPTIDES AND PROTEINS INDUCED BY PEROXYL AND CARBON-CENTERED RADICALS
Adquisición de un equipo UHPLC-MS/MS para fortalecer la investigación interdisciplinaria en Ciencias Químicas y Farmacéuticas en la Facultad de Química de la Pontificia Universidad Católica de Chile.
ESTUDIO DEL DAÑO OXIDATIVO SOBRE PROTEÍNAS MIOFIBRILARES MEDIADO POR RADICALES PEROXILO HIDROSOLUBLES=> ROL DE POLIFENOLES OBTENIDOS DE PIEL Y SEMILLA DE MANGO (MANGIFERA INDICA L.) COMO POTENCIALES COMPUESTOS ANTIOXIDANTES
REACTIVITY OF ANTIOXIDANTS TOWARD NITROXIDES AND PHOTOINDUCED FREE RADICALS IN COMPARTMENTALIZED SYSTEMS.
EXTENDING THE USE OF PYROGALLOL RED AS PROBE IN METHODOLOGIES AIMED TO ESTIMATE THE SCAVENGING ACTIVITY OF BEVERAGES AND FOODS TOWARDS NITRITE, HYPOCHLOROUS ACID, CHLORAMINES AND PEROXYL RADICALS.
NITROXIDES PREFLUORESCENT PROBLES ON THE FREE RADICAL MONITORING IN PROTEINS, MONOLAYERS AND CELLS
DESARROLLO Y APLICACION DE NUEVOS METODOS PARA EVALUAR CAPACIDAD ANTIOXIDANTE EN MEDIO ACUOSO, MEDIO ORGANICO Y MICELAS.
ESTUDIO CINETICO DE LA REACTIVIDAD SECUNDARIA DE FLAVONOIDES, FENOLES Y POLIFENOLES RELACIONADOS
SINTESIS Y CARACTERIZACION ELECTROQUIMICA DE 1.4-DIHIDROPIRIDINAS-4-SUSTITUIDAS.

Review (2)

The role of protein-derived free radicals as intermediaries of oxidative processes
Evaluating the antioxidant capacity of natural products: A review on chemical and cellular-based assays
125
Camilo López

prof. Asociado

Química Física

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

31
Hernan Speisky

PROFESOR TITULAR

UNIVERSITY OF CHILE

SANTIAGO, Chile

27
ALEXIS ASPEE

Profesor Titular

Ciencias del Ambiente

UNIVERSIDAD DE SANTIAGO DE CHILE

Santiago, Chile

13
claudio olea

Full Professor

Inorganica y Analitica

UNIVERSIDAD DE CHILE

Santiago, Chile

12
Margarita Aliaga

Associate Professor

Química Física

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

11
Raquel Bridi

Profesor Asistente

Departamento de Farmacia

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

10
Juan Squella

Académico

Química Orgánica y Físico Química

UNIVERSIDAD DE CHILE, FACULTAD DE CIENCIAS QUÍMICAS Y FARMACÉUTICAS

Santiago, Chile

7
Elias Atala

Project Manager

Naturex- Chile botanics division

Santiago, Chile

6
Eduardo Pino

Acádemico

Ciencias del Ambiente

UNIVERSIDAD DE SANTIAGO DE CHILE

Santiago, Chile

3
Maria Soledad Ureta

UNIVERSIDAD DE SANTIAGO DE CHILE

Santiago, Chile

3
EVA DORTA

Investigador Asociado

Química-Física

Pontificia Universidad Católica de Chile

Santiago, Chile

3
Pablo Barrías

Profesor por hora

Ciencias del Ambiente

Universidad de Santiago de Chile

Santiago, Chile

3
Germán Barriga

Asociado

Quimica

Universidad Metropolitana de Ciencias de la Educación

Ñuñoa, Chile

3
Alvaro Cañete

Profesor-investigador

instituto de ciencias químicas aplicadas

Universidad Autónoma de Chile

Santiago, Chile

3
María Rubio

ACADEMICO

CIENCIAS DEL AMBIENTE

UNIVERSIDAD DE SANTIAGO DE CHILE

Santiago, Chile

3
Fernanda Perez

Investigadora senior principal

Síntesis orgánica

Ientropia SPA

Santiago, Chile

2
Carolina Aliaga

Profesora Titular

Ciencias de Ambiente

UNIVERSIDAD DE SANTIAGO DE CHILE

Santiago, Chile

2
Felipe Avila

Profesor Asistente

UNIVERSIDAD DE TALCA

Talca, Chile

2
Maria Alejandra Orrego

Asistente de Investigación

Química de los Materiales

Universidad de Santiago de Chile

Santiago, Chile

2
Angel Leiva

Full Professor

Physical Chemistry

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

2
Roberto Ebensperger

Associate Professor

Pharmacy

Pontificia Universidad Católica de Chile

Santiago, Chile

2
JAIME MELLA

PROFESOR ADJUNTO

INSTITUTO DE QUIMICA Y BIOQUIMICA

UNIVERSIDAD DE VALPARAISO

VALPARAISO, Chile

2
Javiera Cortés

Estudiante de Doctorado

Instituto de Ingeniería Biológica y Médica

Pontificia Universidad Católica de Chile

Santiago, Chile

2
Ana Edwards

Full Professor

Chemistry

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

2
Maria Alvarez

Profesor Asociado

Farmacia

Pontificia Universidad Catolica de Chile

Santiago, Chile

2
MONICA ANTILEN

Profesor Asociado

quimica Inorganica

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

1
Gloria Montenegro

Profesor Titular

Departamento Ciencias Vegetales

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

1
Ady Giordano

Profesor Asistente

Química

Pontificia Universidad Católica de Chile

Santiago, Chile

1
Edgardo Cruces

Investigador

Vicerrectoría de Investigación y Postgrado

Universidad de Atacama

Copiapo, Chile

1
Iván Gómez

Profesor Titular

Instituto de Ciencias Marinas y Limnológicas

UNIVERSIDAD AUSTRAL DE CHIE

Valdivia, Chile

1
Edmundo Bordeu

Professor

Fruticultura y Enología

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

1
Rodrigo Montecinos

Profesor Asistente

Química-Física

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

1
Gerald Zapata

DEPARTAMENTO DE QUÍMICA INORGÁNICA Y ANALÍTICA FACULTAD DE CIENCIAS QUÍMICAS Y FARMACÉUTICAS UNIVERSIDAD DE CHILE

Santiago, Chile

1
Fernando Gonzalez

Titular Professor

Facultad de Ciencias de la Vida

Universidad Andres Bello

Santiago, Chile

1
Alfredo Molina

Profesor Asistente

Instituto de Investigación en Ciencias Odontológicas

Universidad de Chile

santiago, Chile

1
Ricardo Tapia

Full Professor

Organic Chemistry

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

1
Horacio Poblete

Profesor Conferenciante

Universidad de Talca

Talca, Chile

1
GLORIA CARDENAS

Full Professor

Department of Environmental Science

UNIVERSIDAD DE SANTIAGO DE CHILE

Santiago, Chile

1
Marcelo Kogan

Academico

Quimica Farmacologica y Toxicologica

UNIVERSIDAD DE CHILE, FACULTAD DE CIENCIAS QUÍMICAS Y FARMACÉUTICAS

Santiago, Chile

1
Claudia Mardones

Académica

Departamento Análisis Instrumental

UNIVERSIDAD DE CONCEPCIÓN

Concepción, Chile

1
Carola Vergara

Profesor Asociado

Departamento de Análisis Instrumental

Universidad de Concepción

Concepcion, Chile

1
Mario Faúndez

Profesor Asistente

Farmacia

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

1
David David

Full professor

Analitycal and Inorganic Chemistry

UNIVERSIDAD DE CONCEPCION

Concepción, Chile

1
Denis Fuentealba

PROFESOR ASOCIADO

QUIMICA FISICA

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

1
Daniela Andrade

academico

Universidad Austral de Chile

puerto montt , Chile

1
Francisco Mura

Investigador postdoctoral

Química y Biología

Universidad de Santiago de Chile

Santiago, Chile

1
Víctor Castro

Profesor Asistente

Departamento de Biología

UNIVERSIDAD DE CHILE

Ñuñoa, Chile

1
Angelica Fierro

Associate

Chemistry

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

1
ANA ZÁRATE

investigadora

Químca-Física

Pontificia Universidad Católica de Chile

Santiago, Chile

1
Marco Soto

Profesor Asociado

Química Física

Pontificia Universidad Católica de Chile

Santiago, Chile

1
CAROLINA JULLIAN

Profesor Asociado

Quimica Organica y Fisicoquimica

UNIVERSIDAD DE CHILE

SANTIAGO, Chile

1
Edgar Pastene

Profesor

Ciencias Básias

Universidad del Bío-Bío

Chillán, Chile

1
Alejandra Herrera

Estudiante de Doctorado

UNIVERSIDAD DE BARCELONA

1
Ricardo Zamora

Postdoctoral Researcher

Institute for Bioengineering of Catalonia (IBEC)

Barcelona, España

1
María Rodríguez

Profesora Asociada

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

Santiago, Chile

1
Francisco Valenzuela

Farmacovigilancia de vacunas

ISP

Santiago, Chile

1
Claudia Yáñez

académico

Química Orgánica y Físico Química

Universidad de Chile

Santiago, Chile

1
Benjamí­n Diethelm

Ayudante de Investigación

Genética Molecular y Microbiología

Pontificia Universidad Católica de Chile

Santiago, Chile