Man

Carlos David Pessoa Mahana

Profesor Titular

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

Líneas de Investigación


Desarrollo de Moduladores Sintéticos Benzimidazólicos del Sistema Endocannabinoide. Química Medicinal de Cannabinoides. Síntesis de heterociclos bioactivos. Sistema Serotoninérgico.

Educación

  •  Organic Synthesis, PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE. Chile, 1998

Experiencia Académica

  •   PROFESOR TITULAR Full Time

    PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

    FACULTAD DE QUÍMICA Y DE FARMACIA

    SANTIAGO, Chile

    1994 - A la fecha

Experiencia Profesional

  •   PROFESOR TITULAR Full Time

    PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

    Santiago, Chile

    1994 - A la fecha

Formación de Capital Humano


A la fecha he doctorado a:
Dr.Jaime Mella
Profesor Adjunto
Laboratorio de Química Medicinal y Orgánica
Instituto de Química y Bioquímica
Facultad de Ciencias
Universidad de Valparaíso

Dr.Javier Romero
Profesor Asistente
Departamento de Química Orgánica y Físicoquímica
Facultad de Ciencias Químicas y Farmacéuticas
Universidad de Chile

Dr. Christian Espinosa
Profesor Asistente
Departamento de Farmacia
Facultad de Química y de Farmacia
Pontificia Universidad Católica de Chile

Por dar su examen final durante junio 2020 está Rossy Escobar, Directora de la Carrera de Química y Farmacia de la Universidad Autónoma, sede Talca.
A la vez he dirigido numerosas tesis de licenciatura desde 1998 a la fecha.
Desde el punto de vista de clases presenciales, he dictado el curso de postgrado de Fármaco-Química para la carrera de Química y Farmacia desde 1994 a la fecha. Además dicto un curso optativo en nuestro programa de Doctorado en Química, llamado "Química Medicinal".


Difusión y Transferencia


He participado en diversos eventos de difusión que incluyen: congreso nacional de estudiantes de Química y farmacia, Workshop de Química, charlas.



 

Article (59)

New Pyridone-Based Derivatives as Cannabinoid Receptor Type 2 Agonists
Nitrofuran drugs beyond redox cycling: Evidence of Nitroreduction-independent cytotoxicity mechanism
Synthesis, Docking, 3-D-Qsar, and Biological Assays of Novel Indole Derivatives Targeting Serotonin Transporter, Dopamine D2 Receptor, and Mao-A Enzyme: In the Pursuit for Potential Multitarget Directed Ligands
Synthesis, in vitro evaluation and molecular docking of a new class of indolylpropyl benzamidopiperazines as dual AChE and SERT ligands for Alzheimer's disease
Synthesis, in vitro evaluation and molecular docking of a new class of indolylpropyl benzamidopiperazines as dual AChE and SERT ligands for Alzheimer’s disease
Cannabidiol binding and negative allosteric modulation at the cannabinoid type 1 receptor in the presence of delta-9-tetrahydrocannabinol: An In Silico study
Three-Dimensional Quantitative Structure-Activity Relationships (3D-QSAR) on a Series of Piperazine-Carboxamides Fatty Acid Amide Hydrolase (FAAH) Inhibitors as a Useful Tool for the Design of New Cannabinoid Ligands
Synthesis and biological evaluation of potential acetylcholinesterase inhibitors based on a benzoxazine core
2D-QSAR and 3D-QSAR/CoMSIA Studies on a Series of (R)-2-((2-(1H-Indol-2-yl)ethyl)amino)-1-Phenylethan-1-ol with Human beta(3)-Adrenergic Activity
Combined CoMFA and CoMSIA 3D-QSAR study of benzimidazole and benzothiophene derivatives with selective affinity for the CB2 cannabinoid receptor
Effect of alpha lipoic acid on leukotriene A(4) hydrolase
NADPH oxidase activity: Spectrophotometric determination of superoxide using pyrogallol red
Synthesis and Docking of Novel 3-Indolylpropyl Derivatives as New Polypharmacological Agents Displaying Affinity for 5-HT1AR/SERT
Extended N-Arylsulfonylindoles as 5-HT6 Receptor Antagonists: Design, Synthesis & Biological Evaluation
Synthesis, binding assays, cytotoxic activity and docking studies of benzimidazole and benzothiophene derivatives with selective affinity for the CB2 cannabinoid receptor
Design, Synthesis, Biological Evaluation and Binding Mode Modeling of Benzimidazole Derivatives Targeting the Cannabinoid Receptor Type 1
3D-QSAR/CoMFA-Based Structure-Affinity/Selectivity Relationships of Aminoalkylindoles in the Cannabinoid CB1 and CB2 Receptors
3D-QSAR/CoMFA-based structure-affinity/selectivity relationships of aminoalkylindoles in the cannabinoid CB1 and CB2 receptors.
3D-QSAR/CoMFA-based structure-affinity/selectivity relationships of aminoalkylindoles in the cannabinoid CB1 and CB2 receptors.
Synthesis and Biological Screening of Novel Indolalkyl Arenes Targeting the Serotonine Transporter
Synthesis and biological screening of novel indolalkyl arenes targeting the serotonine transporter.
Design, Synthesis, Binding and Docking-Based 3D-QSAR Studies of 2-Pyridylbenzimidazoles-A New Family of High Affinity CB1 Cannabinoid Ligands
Synthesis, docking and pharmacological evaluation of novel homo- and hetero-bis 3-piperazinylpropylindole derivatives at SERT and 5-HT1A receptor
Synthesis, docking and pharmacological evaluation of novel homo- and hetero-bis 3-piperazinylpropylindole derivatives at SERT and 5-HT1A receptor.
Biological activities and correlations tendency of electrochemical properties of some indolizino[1,2-b]quinoline derivatives.
Synthesis, 5-Hydroxytriptamine 1A Receptor Affinity and Docking Studies of 3-[3-(4-Aryl-1-piperazinyl)-propyl]-1H- Indole Derivatives
Synthesis, Docking Studies and Biological Evaluation of Benzo[b]thiophen-2-yl-3-(4-arylpiperazin-1-yl)-propan-1-one Derivatives on 5-HT1A Serotonin Receptors
Evaluation of the Membrane Permeability (PAMPA and Skin) of Benzimidazoles with Potential Cannabinoid Activity and their Relation with the Biopharmaceutics Classification System (BCS)
Interaction of 5-aminosalicylic acid with nitrous acid: formation of the diazonium derivative and nitric oxide release
SYNTHESIS OF 1-BENZYL-3-[4-(ARYL-1-PIPERAZINYL) CARBONYL]-1H-INDOLES. NOVEL LIGANDS WITH POTENTIAL D4 DOPAMINERGIC ACTIVITY
Synthesis, characterization, and electrochemical studies of new 5-and 6-nitro N-acyl-1H-indazoles
Antioxidant Capacity of Pure Compounds and Complex Mixtures Evaluated by the ORAC-Pyrogallol Red Assay in the Presence of Triton X-100 Micelles
Synthesis of a novel series of 4-arylpiperazinyl derivatives linked to a 2-(pyridin-3-yl)-1H-benzimidazole as new Delavirdine analogues.
Microwave-assisted synthesis and regioisomeric structural elucidation of novel benzimidazo[1,2d][1,4]benzodiazepinone derivatives
SCAVENGING ACTIVITY OF DICLOFENAC. INTERACTION WITH ABTS RADICAL CATION AND PEROXYL RADICALS
Solvent-free microwave-promoted Michael addition of aza-nucleophiles to benzo[b]thiophen-2-yl-2-propenone
Synthesis of conformationally restricted n-{4-[4-(4,7-dimethoxy-benzo[b]thiophene–2–carbonyl)-1-piperazinyl]phenyl}-arylcarboxamides. Potential ligands with 5-ht1a binding affinity.
Biological evaluation of novel 6-arylbenzimidazo [1,2-c]quinazoline derivatives as inhibitors of LPS-induced TNF-alpha secretion
Computational modeling study of functional microdomains in cannabinoid receptor type 1
Docking and QSAR studies for the bisphenylbenzimidazole family of non-nucleoside inhibitors of HIV-1 reverse transcriptase
Influence of Lipophilia and of the Vehicle Used in the Transdermal Absorption of Novel Benzimidazole Compounds with Possible Anti-HIV Activity.
Synthesis of a novel series of 4-arylpiperazinyl derivatives linked to a 2-(pyridin-3-yl)-1H-benzimidazole as new Delavirdine analogues
1-benzoyl-2-(2-nitrophenyl)-1H-benzimidazole derivatives: A novel approach to the development of new HIV-1 reverse transcriptase inhibitors
Synthesis of 2-benzothienyl carbonyl 4-arylpiperazines as novel delavirdine analogs
Synthesis of benzo[b]thiophene carboxamides connected to 4-arylpiperazines through a benzylic spacer: Potential Ligands with 5-HT1A binding affinity
Studies on quinones. Part 41: Synthesis and cytotoxicity of isoquinoline-containing polycyclic quinones
A facile approach for new dibenzo [b,f][1,5] diazocinones
Role of CB1 receptorsand Gi/o protein activation in the modulation of synaptosomal Na+,K+-ATPase activity by WIN55,212-2 and d 9-THC
Solvent-free synthesis of 6-arylbenzimidazo[1,2-c]quinazolines under microwave irradiation
Synthesis of 4-arylpiperazine derivatives of moclobemide: Potential antidepressants with a dual mode of action
A Synthethic Overview of New Molecules with 5-HT1a Binding Affinities
Synthesis and Antiprootozoal Activity of Naphtofuranquinones and Naphtothiophenequinones containing a Fused Thiazole Ring
Studies on quinones. Part 36. Synthesis and trypanocidal activity of 2-alkoxycarbonylbenzo[b]thiophene-4,7-quinones
Studies on Quinones. Part.35. “Access to Antiprotozoal Active Euryfurylquinones and Hydroquinones
Studies on quinones. Part 34: The reaction of styrene with activated 1,4-benzoquinones: access to potential antiprotozoal pyranobenzoquinones
Regiospecific Michael Reaction of (+)-Euryfuran with activated 1,4- Benzoquinones
Estudios sobre quinonas. Parte 29. Reacciones inusuales de quinonas con enaminas.
Reaction of Spiroanthracenones with DDQ: a One-pot Synthesis of Benz[a]anthraquinones
Comparative determination of photodegradation kinetics of quinolones

Proyecto (7)

SYNTHESIS OF NOVEL INDOLE DERIVATIVES TARGETING: SEROTONERGIC (SERT INHIBITION /5-HT4 AGONIST ACTIVITY), CHOLINERGIC (ACETYLCHOLINESTERASE INHIBITION) AND BETA-AMYLOID DEPOSITION, IN THE SEARCH OF MULTIFUNCTIONAL AGENTS IN ALZHEIMER´S DISE
Synthesis, binding mode prediction, biological evaluation and SAR analysis of benzoimidazole-based modulators of the endocannabinoid system
A Synthetic approach towards novel series of 3-(3-(1-piperazinyl)propyl-1H-indole derivatives as monoaminergic multi-target agents. Docking studies and pharmacological evaluation at sert, D2, and Mao-A Receptors
Synthesis and structure-activity relationships studies of novel CB1 receptor ligands
A rational synthetic approach to 3-indolealkyl(aryl)piperazine derivatives as new hetero and homobivalent ligands with potential serotonergic activity
Búsqueda de nuevos inhibidores no nucleosídicos de la enzima transcriptasa reversa de HIV-1: Síntesis y evaluación biológica de nuevos derivados benzoimidazólicos
Estudio de síntesis de derivados 2-benzotienil- y ((4-arilpiperazinil))-azoalquil benzo[b]tiofenos y de analogos triciclícos semirigidizados de benzotieno (2,3-d) azepinas. Una propuesta sintética orientada a la búsqueda de de ligandos serotoninérgicos de mecanismo dual
23
Carlos Pessoa

Profesor Titular

Departamento de Farmacia

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

7
JAIME MELLA

PROFESOR ADJUNTO

INSTITUTO DE QUIMICA Y BIOQUIMICA

UNIVERSIDAD DE VALPARAISO

VALPARAISO, Chile

6
Javier Romero

Profesor Asistente

Departamento de Química Orgánica y Fisicoquímica

Universidad de Chile

Santiago, Chile

2
Ricardo Tapia

Full Professor

Organic Chemistry

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

2
Carlos Gallardo

Director Médico

Laboratorio Ximena Polanco

Santiago, Chile

2
Angelica Fierro

Associate

Chemistry

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

2
María José Torres

Docente

Farmacia

Pontificia Universidad Católica de Chile

Santiago, Chile

2
HERNAN PESSOA

Profesor Asociado

Química Orgánica y Fisicoquímica

UNIVERSIDAD DE CHILE

SANTIAGO, Chile

2
Patricio Iturriaga

Profesor Asociado A

Ciencias Quimicas y Recursos Naturales

UNIVERSIDAD DE LA FRONTERA

Temuco, Chile

1
Paul Silva

Profesor

Química Orgánica y Fisicoquímica

Universidad de Chile

Santiago, Chile

1
Eduardo Gallardo

Tesista de doctorado

Química farmacológica y toxicológica

Universidad de Chile

Santiago, Chile

1
Jorge Soto

Profesor Asistente

Departamento de Ciencias Quimicas

Universidad Andrés Bello

Viña del Mar, Chile

1
Maria Zúñiga

Proffesor

Química Inorgánica y Analitica

Universidad de Chile

Santiago, Chile

1
Rossy Escobar

Directora de Carrera

Facultad de Ciencias de la Salud

Universidad Autónoma de Chile

Talca, Chile

1
Claudio Méndez

Investigador en Estudios Clínicos

Farmacia

Clínica Santa María

Santiago, Chile

1
Marcelo Kogan

Academico

Quimica Farmacologica y Toxicologica

UNIVERSIDAD DE CHILE, FACULTAD DE CIENCIAS QUÍMICAS Y FARMACÉUTICAS

Santiago, Chile

1
CLAUDIO SAITZ

Associate Prof.

Organic and Phisycal Chemistry

UNIVERSIDAD DE CHILE-FAC. CS. QUIMICAS Y FARMACEUTICAS

Santiago, Chile

1
Mario Faúndez

Profesor Asistente

Farmacia

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

1
Marco Mellado

Investigador

Pontificia Universidad Católica de Valparaíso

Valparaíso, Chile

1
Mauricio Cuellar

UNIVERSIDAD DE VALPARAÍSO

Valparaíso, Chile

1
Miguel Reyes

Full Professor

Facultad de Ciencias Médicas

UNIVERSIDAD DE SANTIAGO DE CHILE, FACULTAD DE CIENCIAS MÉDICAS, ESCUELA DE MEDICINA

Santiago, Chile

1
Gerald Zapata

DEPARTAMENTO DE QUÍMICA INORGÁNICA Y ANALÍTICA FACULTAD DE CIENCIAS QUÍMICAS Y FARMACÉUTICAS UNIVERSIDAD DE CHILE

Santiago, Chile

1
Gonzalo Cabrera

Academic

Cell and Molecular Biology

FACULTAD DE MEDICINA, UNIVERSIDAD DE CHILE

Santiago, Chile

1
Cesar Morales

Associate Professor

Universidad Bernardo O'Higgins

Santiago, Chile

1
ANA ZÁRATE

investigadora

Químca-Física

Pontificia Universidad Católica de Chile

Santiago, Chile

1
Christopher Cerda

Profesor

Universidad Bernardo O'Higgins

Santiago, Chile

1
CHRISTIAN ESPINOSA

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

SANTIAGO, Chile

1
Javiera Cortés

Estudiante de Doctorado

Instituto de Ingeniería Biológica y Médica

Pontificia Universidad Católica de Chile

Santiago, Chile

1
Carlos Lagos

Profesor Asociado

FACULTAD DE MEDICINA Y CIENCIA

UNIVERSIDAD SAN SEBASTIÁN

SANTIAGO, Chile