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Miguel Reyes Parada

Full Professor

UNIVERSIDAD DE SANTIAGO DE CHILE, FACULTAD DE CIENCIAS MÉDICAS, ESCUELA DE MEDICINA

Santiago, Chile

Medicinal Chemistry, Pharmacology, Neuropharmacology, Polypharmacology

Chemist and Pharmacist, UNIVERSIDAD DE CHILE. Chile, 1992
Biological Sciences, Universidad de la República Oriental de Uruguay. Uruguay, 1996

Full professor Full Time

UNIVERSIDAD DE SANTIAGO DE CHILE

Ciencias Médicas

Santiago, Chile

1998 - A la fecha

Full Professor Full Time

Universidad de Santiago de Chile

Santiago, Chile

1998 - A la fecha

- MSc. Thesis in Chemistry, University of Chile. “Synthesis, enantiomeric resolution and evaluation as MAO-inhibitors of 4-methylthio amphetamine and N-alkylated derivatives C. Hurtado-Guzmán. 2001.

- PhD. Thesis in Chemistry, University of Chile. “Synthesis of phenethylamine derivatives as potential MAO-inhibitors”. A. Gallardo-Godoy. 2003.

- PhD. Thesis in Chemistry, University of Santiago de Chile. Quantitative structure-activity relationships of phenethylamine derivatives as potential MAO-inhibitors. A. Fierro. 2007

- PhD. Thesis in Biotechnology, University of Santiago de Chile. “Similarities between the binding sites of monoamine oxidase and the serotonin transporter: a study using mathematical algorithms, molecular simulation and biological assays”. G. Núñez. 2015

- PhD. Thesis in Biotechnology, University of Santiago de Chile. “Determination of similarities between the active sites of monoaminergic proteins and nicotinic receptors: an approach for the rational design of polypharmacological drugs". P. Möller. 2017


Amphetamine Derivatives as Monoamine Oxidase Inhibitors. Reyes-Parada, Miguel. Iturriaga-Vasquez, Patricio. Cassels, Bruce K. Article FRONTIERS IN PHARMACOLOGY (2020)
Synthesis, in vitro evaluation and molecular docking of a new class of indolylpropyl benzamidopiperazines as dual AChE and SERT ligands for Alzheimer's disease. Rodríguez-Lavado, Julio. Gallardo-Garrido, Carlos. Mallea, Michael. Bustos, Victor. Osorio, Rodrigo. Hodar-Salazar, Martín. Chung, Hery. Araya-Maturana, Ramiro. Lorca, Marcos. Pessoa-Mahana, C. David. Mella-Raipan, Jaime. Saitz, Claudio. Jaque, Pablo. Rey Article WOS EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2020)
3D-PP: A Tool for Discovering Conserved Three-Dimensional Protein Patterns ValdÃ©s-JimÃ©nez A.; Larriba-Pey J.-L.; NÃºÃ±ez-Vivanco G.; Reyes-Parada M. Article ISI SCOPUS INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)
Discovery of Novel TASK-3 Channel Blockers Using a Pharmacophore-Based Virtual Screening Ramirez, David; Concha, Guierdy; Arevalo, Barbara; Prent-Penaloza, Luis; Zuniga, Leandro; Kiper, Aytug K.; Rinne, Susanne; Reyes-Parada, Miguel; Decher, Niels; Gonzalez, Wendy; Caballero, Julio Article ISI SCOPUS INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)
Facts and hypotheses about the programming of neuroplastic deficits by prenatal malnutrition. Barra, R.; Morgan, C.; Sáez-Briones, P.; Reyes-Parada, M.; Burgos, H.; Morales, B.; Hernández, A. Article ISI NUTRITION REVIEWS (2019)
Minimal Structural Changes Determine Full and Partial Nicotinic Receptor Agonist Activity for Nicotine Analogues Gonzalez-Gutierrez J.P.; Hodar M.; Viscarra F.; Paillali P.; Guerra-DÃaz N.; Pessoa-Mahana H.; HernÃ¡ndez-Morantes J.J.; PÃ©rez-SÃ¡nchez H.; BermÃºdez I.; Reyes-Parada M.; Iturriaga-VÃ¡squez P. Article ISI SCOPUS MOLECULES (2019)
Synthesis of Novel Nicotinic Ligands with Multimodal Action: Targeting Acetylcholine alpha 4 beta 2, Dopamine and Serotonin Transporters GonzÃ¡lez-GutiÃ©rrez J.P.; Pessoa-Mahana H.A.; Iturriaga-VÃ¡squez P.E.; Reyes-Parada M.I.; Guerra-DÃaz N.E.; Hodar-Salazar M.; Viscarra F.; Paillali P.; NÃºÃ±ez-Vivanco G.; Lorca-Carvajal M.A.; Mella-RaipÃ¡n J.; ZÃºÃ±iga M.C. Article ISI SCOPUS MOLECULES (2019)
Theoretical and Experimental Approaches Aimed at Drug Design Targeting Neurodegenerative Diseases Morales-Navarro, Samuel; Prent-Penaloza, Luis; Rodriguez Nunez, Yeray A.; Sanchez-Aros, Laura; Forero-Doria, Oscar; Gonzalez, Wendy; Campilllo, Nuria E.; Reyes-Parada, Miguel; Martinez, Ana; Ramirez, David Article ISI SCOPUS PROCESSES (2019)
UFR2709, a Nicotinic Acetylcholine Receptor Antagonist, Decreases Ethanol Intake in Alcohol-Preferring Rats Quiroz G.; Sotomayor-ZÃ¡rate R.; GonzÃ¡lez-Gutierrez J.P.; Vizcarra F.; Moraga F.; Bermudez I.; Reyes-Parada M.; Quintanilla M.E.; Lagos D.; Rivera-Meza M.; Iturriaga-VÃ¡squez P. Article ISI SCOPUS FRONTIERS IN PHARMACOLOGY (2019)
Vasopressin in the lateral septum decreases conditioned place preference to amphetamine and nucleus accumbens dopamine release GÃ¡rate-PÃ©rez M.F.; MÃ©ndez A.; Bahamondes C.; Sanhueza C.; GuzmÃ¡n F.; Reyes-Parada M.; Sotomayor-ZÃ¡rate R.; Renard G.M. Article ISI SCOPUS ADDICTION BIOLOGY (2019)
3D similarities between the binding sites of monoaminergic target proteins Nunez-Vivanco, Gabriel; Fierro, Angelica; Moya, Pablo; Iturriaga-Vasquez, Patricio; Reyes-Parada, Miguel Article ISI SCOPUS PLOS ONE (2018)
Neonatal programming with testosterone propionate reduces dopamine transporter expression in nucleus accumbens and methylphenidate-induced locomotor activity in adult female rats Dib, Tatiana; Martinez-Pinto, Jonathan; Reyes-Parada, Miguel; Torres, Gonzalo E.; Sotomayor-Zarate, Ramon Article ISI SCOPUS BEHAVIOURAL BRAIN RESEARCH (2018)
Characterization of a Novel Drosophila SERT Mutant: Insights on the Contribution of the Serotonin Neural System to Behaviors Hidalgo, Sergio; Molina-Mateo, Daniela; Escobedo, Pía; Zarate, Rafaella V; Fritz, Elsa; Fierro, Angélica; Pérez, Edwin G.; Iturriaga-Vasquez, Patricio; Reyes-Parada, Miguel; Varas, Rodrigo; Fuenzalida-Uribe, Nicolás; Campusano, Jorge M. Article ISI SCOPUS ACS Chemical Neuroscience (2017)
Synthesis and Docking of Novel 3-Indolylpropyl Derivatives as New Polypharmacological Agents Displaying Affinity for 5-HT1AR/SERT Pessoa-Mahana, Hernán; Silva-Matus, Paul; Pessoa-Mahana, C. David; Chung, Hery; Iturriaga-Vásquez, Patricio; Quiroz, Gabriel; Möller-Acuña, Patricia; Zapata-Torres, Gerald; Saitz-Barría, Claudio; Araya-Maturana, Ramiro; Reyes-Parada, Miguel Article ISI SCOPUS ARCHIV DER PHARMAZIE (2017)
Geomfinder: A multi-feature identifier of similar three-dimensional protein patterns: A ligand-independent approach Núñez-Vivanco G.; Valdés-Jiménez A.; BESOAIN, F; Reyes-Parada M. Article ISI SCOPUS Journal of Cheminformatics (2016)
Geomfinder: a multi-feature identifier of similar three-dimensional protein patterns: a ligand-independent approach. Núñez-Vivanco, Gabriel; Valdés-Jiménez, Alejandro; Besoaín-Pino, Felipe; Reyes-Parada, Miguel Article Journal of Cheminformatics (2016)
The development of novel polypharmacological agents targeting the multiple binding sites of nicotinic acetylcholine receptors Reyes-Parada, Miguel; Iturriaga-Vasquez, Patricio Article ISI SCOPUS EXPERT OPINION ON DRUG DISCOVERY (2016)
The development of novel polypharmacological agents targeting the multiple binding sites of nicotinic acetylcholine receptors. Reyes-Parada, Miguel; Iturriaga-Vasquez Patricio Article Expert Opinion on Drug Discovery (2016)
Multiple binding sites in the nicotinic acetylcholine receptors: An opportunity for polypharmacolgy. Iturriaga-Vásquez Patricio; Alzate-Morales Jans; Bermudez Isabel; Varas Rodrigo; Reyes-Parada Miguel Article PHARMACOLOGICAL RESEARCH (2015)
Similarities between the Binding Sites of SB-206553 at Serotonin Type 2 and Alpha7 Acetylcholine Nicotinic Receptors: Rationale for Its Polypharmacological Profile Moller-Acuna, P; Contreras-Riquelme, JS; Rojas-Fuentes, C; Nunez-Vivanco, G; Alzate-Morales, J; Iturriaga-Vasquez, P; Arias, HR; Reyes-Parada, M Article PLoS ONE (2015)
Similarities between the Binding Sites of SB-206553 at Serotonin Type 2 and Alpha7 Acetylcholine Nicotinic Receptors: Rationale for Its Polypharmacological Profile Moller-Acuna, P; Contreras-Riquelme, JS; Rojas-Fuentes, C; Nunez-Vivanco, G; Alzate-Morales, J; Iturriaga-Vasquez, P; Arias, HR; Reyes-Parada, M Article ISI SCOPUS PLOS ONE (2015)
Synthesis, Biological Evaluation, and Molecular Simulation of Chalcones and Aurones as Selective MAO-B Inhibitors Morales-Camilo, N; Salas, CO; Sanhueza C.; Espinosa-Bustos, C; Sepulveda-Boza, S; Reyes-Parada, M; Gonzalez-Nilo, F; Caroli-Rezende, M; Fierro, A. Article ISI SCOPUS Chemical Biology & Drug Design (2015)
Synthesis, Biological Evaluation, and Molecular Simulation of Chalcones and Aurones as Selective MAO-B Inhibitors Morales-Camilo, N; Salas CO.; Sanhueza C.; Espinosa-Bustos, C; Sepulveda-Boza, S; Reyes-Parada, M; Gonzalez-Nilo, F; Caroli-Rezende, M; Fierro A. Article Chemical Biology and Drug Design (2015)
Improving Amphetamine Therapeutic Selectivity: N,N-dimethyl-MTA has Dopaminergic Effects and does not Produce Aortic Contraction Sotomayor-Zárate R, Jara P, Araos P, Vinet R, Quiroz G, Renard GM, Espinosa P, Hurtado-Guzmán C, Moya PR, Iturriaga-Vásquez P, Gysling K, Reyes-Parada M. Article ISI SCOPUS Basic & clinical pharmacology & toxicology (2014)
Improving Amphetamine Therapeutic Selectivity: N,N-dimethyl-MTA has Dopaminergic Effects and does not Produce Aortic Contraction Sotomayor-Zárate R, Jara P, Araos P, Vinet R, Quiroz G, Renard GM, Espinosa P, Hurtado-Guzmán C, Moya PR, Iturriaga-Vásquez P, Gysling K, Reyes-Parada M. Article Basic and Clinical Pharmacology and Toxicology (2014)
Synthesis, docking and pharmacological evaluation of novel homo- and hetero-bis 3-piperazinylpropylindole derivatives at SERT and 5-HT1A receptor Pessoa-Mahana H.; Gonzalez-Lira, C; Fierro A.; Zapata-Torres, G; Pessoa-Mahana, CD; Ortiz-Severin, J; Iturriaga-Vasquez, P; Reyes-Parada, M; Silva-Matus, P; Saitz-Barria, C; Araya-Maturana, R Article BIOORGANIC & MEDICINAL CHEMISTRY (2013)
Synthesis, docking and pharmacological evaluation of novel homo- and hetero-bis 3-piperazinylpropylindole derivatives at SERT and 5-HT1A receptor Pessoa-Mahana H.; Gonzalez-Lira, C; Fierro, A.; Zapata-Torres, G; Pessoa-Mahana, CD; Ortiz-Severin, J; Iturriaga-Vasquez, P; Reyes-Parada, M; Silva-Matus, P; Saitz-Barria, C; Araya-Maturana, R Article ISI SCOPUS Bioorganic and Medicinal Chemistry (2013)
4-Methylthioamphetamine Increases Dopamine in the Rat Striatum and has Rewarding Effects In Vivo Sotomayor-Zarate, R; Quiroz, G; Araya K.A.; Abarca, J; Ibanez M.R.; Montecinos, A; Guajardo, C.; Nuñez G.; Fierro, A.; Moya, P.R.; Iturriaga-Vasquez, P; Gomez-Molina C.; Gysling, K; Reyes-Parada, M Article ISI SCOPUS Basic & clinical pharmacology & toxicology (2012)
4-Methylthioamphetamine Increases Dopamine in the Rat Striatum and has Rewarding Effects In Vivo Sotomayor-Zarate, R; Quiroz, G; Araya K.A.; Abarca J.; Ibanez M.R.; Montecinos A.; Guajardo C.; Nuñez G.; Fierro A.; Moya P.R.; Iturriaga-Vasquez, P; Gomez-Molina C.; Gysling K.; Reyes-Parada, M Article BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY (2012)
Acutely applied MDMA enhances long-term potentiation in rat hippocampus involving D1/D5 and 5-HT2 receptors through a polysynaptic mechanism Rozas C.; Loyola S; Ugarte, G.; Zeise M.L.; Reyes-Parada, M; Pancetti F.; Rojas P.; Morales, B Article ISI SCOPUS EUROPEAN NEUROPSYCHOPHARMACOLOGY (2012)
Acutely applied MDMA enhances long-term potentiation in rat hippocampus involving D1/D5 and 5-HT2 receptors through a polysynaptic mechanism Rozas C; Loyola S; Ugarte G.; Zeise, M.L.; Reyes-Parada, M; Pancetti, F; Rojas P.; Morales B Article EUROPEAN NEUROPSYCHOPHARMACOLOGY (2012)
Synthesis, 5-hydroxytryptamine 1A receptor affinity and docking studies of 3-[3-(4-aryl-1-piperazinyl)-propyl]-1H-indole derivatives Pessoa-Mahana, H; NÃºÃ±ez C.U.; Araya-Maturana, R; BarrÃa C.S.; Zapata-Torres G; Pessoa-Mahana C.D.; Iturriaga-Vasquez, P.; Mella-RaipÃ¡n J.; Reyes-Parada M.; Celis-Barros, C Article SCOPUS Chemical and Pharmaceutical Bulletin (2012)
Synthesis, 5-Hydroxytryptamine(1A) Receptor Affinity and Docking Studies of 3-[3-(4-Aryl-1-piperazinyl)-propyl]-1H-Indole Derivatives Pessoa-Mahana H.; Nunez, CU; Araya-Maturana, R; Barria, CS; Zapata-Torres, G; Pessoa-Mahana, CD; Iturriaga-Vasquez, P; Mella-Raipan J.; Reyes-Parada, M; Celis-Barros, C Article ISI CHEMICAL PHARMACEUTICAL BULLETIN (2012)
Synthesis, 5-Hydroxytryptamine(1A) Receptor Affinity and Docking Studies of 3-[3-(4-Aryl-1-piperazinyl)-propyl]-1H-Indole Derivatives Pessoa-Mahana H.; Nunez, CU; Araya-Maturana, R; Barria, CS; Zapata-Torres, G; Pessoa-Mahana, CD; Iturriaga-Vasquez, P; Mella-Raipan J.; Reyes-Parada, M; Celis-Barros, C Article CHEMICAL & PHARMACEUTICAL BULLETIN (2012)
Hacia nuevos modelos de enseñanza- aprendizaje en ciencias de la salud Article Educacion Medica (2011)
Implementación y evaluación de una metodología de autoaprendizaje dirigido, para estudiantes de dos carreras de ciencias de la salud. R. Herrera R., H. Herrera R., M. Arancibia M., C. Massardo D., D. González Z., E. Rugiero P., M. Reyes-Parada. Article Revista de Educacion en Ciencias de la Salud (2011)
Polyphosphate synthesis as a target for novel antibiotics Chávez F.P.; Reyes-Parada, M; Jerez, C.A.; Lagos, C. F.; Guiliani N. Article Current Enzyme Inhibition (2011)
Polyphosphate synthesis as a target for novel antibiotics. F.P. Chávez, C.A. Lagos, M. Reyes-Parada, N. Guiliani, C.A. Jerez. Article Current Enzyme Inhibition (2011)
2-Arylthiomorpholine derivatives as potent and selective monoamine oxidase B inhibitors Luhr, S; Vilches-Herrera, M; Fierro, A.; Ramsay, RR; Edmondson, DE; Reyes-Parada, M; Cassels, BK; Iturriaga-Vasquez, P Article ISI SCOPUS Bioorganic and Medicinal Chemistry (2010)
2-Arylthiomorpholine derivatives as potent and selective monoamine oxidase B inhibitors. Lühr, Susan; Vilches-Herrera, Marcelo; Fierro, Angélica; Ramsay, Rona R; Edmondson, Dale E; Reyes-Parada, Miguel; Cassels, Bruce K; Iturriaga-Vásquez, Patricio Article Bioorganic & medicinal chemistry (2010)
MDMA ("ecstasy") impairs learning in the Morris Water Maze and reduces hippocampal LTP in young rats Arias-Cavieres, A; Rozas C.; Reyes-Parada, M; Barrera, N; Pancetti F.; Loyola S; Lorca RA; Zeise, ML; Morales, B Article ISI SCOPUS Neuroscience Letters (2010)
MDMA ("ecstasy") impairs learning in the Morris Water Maze and reduces hippocampal LTP in young rats. Arias-Cavieres A, Rozas C, Reyes-Parada M, Barrera N, Pancetti F, Loyola S, Lorca RA, Zeise ML, Morales B. Article Neuroscience Letters (2010)
Naphthylisopropylamine and N-benzylamphetamine derivatives as monoamine oxidase inhibitors Vilches-Herrera, M; Miranda-Sepulveda, J; Rebolledo-Fuentes, M; Fierro, A.; Luhr, S; Iturriaga-Vasquez, P; Cassels, BK; Reyes-Parada, M Article ISI SCOPUS BIOORGANIC & MEDICINAL CHEMISTRY (2009)
Naphthylisopropylamine and N-benzylamphetamine derivatives as monoamine oxidase inhibitors. Vilches-Herrera M, Miranda-Sepúlveda J, Rebolledo-Fuentes M, Fierro A, Lühr S, Iturriaga-Vasquez P, Cassels BK, Reyes-Parada M Article Bioorganic and Medicinal Chemistry (2009)
N,N-dimethyl-thioamphetamine and methyl-thioamphetamine, two non-neurotoxic substrates of 5-HT transporters, have scant in vitro efficacy for the induction of transporter-mediated 5-HT release and currents Gobbi, M; Funicello, M; Gerstbrein, K; Holy, M; Moya, PR; Sotomayor, R; FORRAY, MI; Gysling, K; Paluzzi, S; Bonanno G.; Reyes-Parada, M; Sitte, HH; Mennini, T Article ISI SCOPUS JOURNAL OF NEUROCHEMISTRY (2008)
N,N-dimethyl-thioamphetamine and methyl-thioamphetamine, two non-neurotoxic substrates of 5-HT transporters, have scant in vitro efficacy for the induction of transporter-mediated 5-HT release and currents. Gobbi, Marco; Funicello, Marcella; Gerstbrein, Klaus; Holy, Marion; Moya, Pablo R; Sotomayor, Ramón; Forray, María Inés; Gysling, Katia; Paluzzi, Silvio; Bonanno, Giambattista; Reyes-Parada, Miguel; Sitte, Harald H; Mennini, Tiziana Article Journal of neurochemistry (2008)
Prenatal to Early Postnatal Nicotine Exposure Impairs Central Chemoreception and Modifies Breathing Pattern in Mouse Neonates: A Probable Link to Sudden Infant Death Syndrome Eugenín J.; Otarola, M; Bravo, E.; Coddou, C.; Cerpa, V; Reyes-Parada, M; Llona I.; von Bernhardi R. Article ISI SCOPUS JOURNAL OF NEUROSCIENCE (2008)
Prenatal to early postnatal nicotine exposure impairs central chemoreception and modifies breathing pattern in mouse neonates: a probable link to sudden infant death syndrome. Eugenín, Jaime; Otárola, Marcelo; Bravo, Eduardo; Coddou, Claudio; Cerpa, Verónica; Reyes-Parada, Miguel; Llona, Isabel; von Bernhardi, Rommy Article The Journal of neuroscience : the official journal of the Society for Neuroscience (2008)
Functional selectivity of hallucinogenic phenethylamine and phenylisopropylamine derivatives at human 5-hydroxytryptamine (5-HT)(2A) and 5-HT2C receptors Moya, PR; Berg, KA; Gutierrez-Hernandez, MA; Saez-Briones, P; Reyes-Parada, M; Cassels, BK; Clarke, WP Article ISI SCOPUS JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2007)
Functional selectivity of hallucinogenic phenethylamine and phenylisopropylamine derivatives at human 5-hydroxytryptamine (5-HT)2A and 5-HT2C receptors. Moya, Pablo R; Berg, Kelly A; Gutiérrez-Hernandez, Manuel A; Sáez-Briones, Patricio; Reyes-Parada, Miguel; Cassels, Bruce K; Clarke, William P Article The Journal of pharmacology and experimental therapeutics (2007)
Human and rat monoamine oxidase-A are differentially inhibited by (S)-4-alkylthioamphetamine derivatives: Insights from molecular modeling studies Fierro, A.; Osorio-Olivares, M; Cassels, BK; Edmondson, DE; Sepulveda-Boza, S; Reyes-Parada, M Article ISI SCOPUS BIOORGANIC & MEDICINAL CHEMISTRY (2007)
Human and rat monoamine oxidase-A are differentially inhibited by (S)-4-alkylthioamphetamine derivatives: insights from molecular modeling studies. Fierro, Angélica; Osorio-Olivares, Mauricio; Cassels, Bruce K; Edmondson, Dale E; Sepúlveda-Boza, Silvia; Reyes-Parada, Miguel Article Bioorganic & medicinal chemistry (2007)
Changes in antioxidant capacity of Tannat red wines during early maturation Echeverry, C; Ferreira M.; Reyes-Parada, M; Abin-Carriquiry, JA; Blasina, F; Gonzalez-Neves, G; Dajas, F Article ISI SCOPUS JOURNAL OF FOOD ENGINEERING (2005)
Heteroarylisopropylamines as MAO inhibitors Vallejos G.; Fierro, A.; Rezende, MC; Sepulveda-Boza, S; Reyes-Parada, M Article ISI SCOPUS BIOORGANIC & MEDICINAL CHEMISTRY (2005)
Heteroarylisopropylamines as MAO inhibitors. Vallejos, Gabriel; Fierro, Angélica; Rezende, Marcos Caroli; Sepúlveda-Boza, Silvia; Reyes-Parada, Miguel Article Bioorganic & medicinal chemistry (2005)
Monoamine Oxidase Inhibition In the Light of New Structural Data M. Reyes-Parada; A. Fierro; P. Iturriaga-Vásquez; B. K. Cassels Article ISI Current Enzyme Inhibition (2005)
Sulfur-substituted alpha-alkyl phenethylamines as selective and reversible MAO-A inhibitors: Biological activities, CoMFA analysis, and active site modeling Gallardo-Godoy, A; Fierro, A.; McLean, TH; Castillo M.; Cassels, BK; Reyes-Parada, M; Nichols, DE Article ISI SCOPUS JOURNAL OF MEDICINAL CHEMISTRY (2005)
Sulfur-substituted alpha-alkyl phenethylamines as selective and reversible MAO-A inhibitors: biological activities, CoMFA analysis, and active site modeling. Gallardo-Godoy, Alejandra; Fierro, Angélica; McLean, Thomas H; Castillo, Mariano; Cassels, Bruce K; Reyes-Parada, Miguel; Nichols, David E Article Journal of medicinal chemistry (2005)
"Delayed early morning turn ""ON"" in response to a single dose of levodopa in advanced Parkinson's disease: Pharmacokinetics should be considered [1]" Chana, P; Kuntsmann, C; Reyes-Parada, M; Saez-Briones, P Article JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY (2004)
Delayed early morning turn "ON" in response to a single dose of levodopa in advanced Parkinson's disease: pharmacokinetics should be considered. Chaná, P; Kuntsmann, C; Reyes-Parada, M; Sáez-Briones, P Article Journal of neurology, neurosurgery, and psychiatry (2004)
[Pharmacokinetic comparison of Sinemet and Grifoparkin (levodopa/carbidopa 250/25 mg) in Parkinson s disease: a single dose study]. Chaná, Pedro; Fierro, Angélica; Reyes-Parada, Miguel; Sáez-Briones, Patricio Article Revista mÃ©dica de Chile (2003)
Monoamine oxidase inhibitory properties of optical isomers and N-substituted derivatives of 4-methylthioamphetamine Hurtado-Guzman, C; Fierro, A.; Iturriaga-Vasquez, P; Sepulveda-Boza, S; Cassels, BK; Reyes-Parada, M Article ISI SCOPUS JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY (2003)
Monoamine oxidase inhibitory properties of optical isomers and N-substituted derivatives of 4-methylthioamphetamine. Hurtado-Guzmán, Claudio; Fierro, Angelica; Iturriaga-Vásquez, Patricio; Sepúlveda-Boza, Silvia; Cassels, Bruce K; Reyes-Parada, Miguel Article Journal of enzyme inhibition and medicinal chemistry (2003)
Pharmacokinetic comparison of Sinemet (R) and Grifoparkin (R) (levodopa/carbidopa) in Parkinson's disease: a single dose study Chana, P; Fierro, A.; Reyes-Parada, M; Saez-Briones, P Article ISI REVISTA MEDICA DE CHILE (2003)
Pharmacokinetic comparison of Sinemet® and Grifoparkin® (levodopa/carbidopa) in Parkinson's disease: A single dose study Comparación farmacocinética de Sinemet® y Grifoparkin® (levodopa/carbidopa 250/25 mg) en pacientes con enfermedad de Parkinson avanzada: Un estudio con dosis única Chana C. P.; Fierro H. A.; Reyes-Parada, M; Saez-Briones, P Article REVISTA MEDICA DE CHILE (2003)
p-Methylthioamphetamine and 1-(m-chlorophenyl)piperazine, two non-neurotoxic 5-HT releasers in vivo, differ from neurotoxic amphetamine derivatives in their mode of action at 5-HT nerve endings in vitro Gobbi, M; Moia M.; Pirona, L; Ceglia, I; Reyes-Parada, M; Scorza, C; Mennini, T Article ISI JOURNAL OF NEUROCHEMISTRY (2002)
p-Methylthioamphetamine and 1-(m-chlorophenyl)piperazine, two non-neurotoxic 5-HT releasers in vivo, differ from neurotoxic amphetamine derivatives in their mode of action at 5-HT nerve endings in vitro. Gobbi, M; Moia, M; Pirona, L; Ceglia, I; Reyes-Parada, M; Scorza, C; Mennini, T Article Journal of neurochemistry (2002)
Heterogeneous catalysts in the preparation of 2-aryl-1,3-dinitropropanes from ?-nitrostyrenes or benzaldehydes Fierro, A.; Rezende M.C.; Sepulveda-Boza, S; Reyes-Parada, M; Cassels, B.K. Article SCOPUS JOURNAL OF CHEMICAL RESEARCH-S (2001)
Heterogeneous catalysts in the preparation of 2-aryl-1,3-dinitropropanes from beta-nitrostyrenes or benzaldehydes Fierro, A.; Rezende, MC; Sepulveda-Boza, S; Reyes-Parada, M; Cassels, BK Article ISI JOURNAL OF CHEMICAL RESEARCH-S (2001)
ALEPH-2, a suspected anxiolytic and putative hallucinogenic phenylisopropylamine derivative, is a 5-HT(2a) and 5-HT(2c) receptor agonist Acua-Castillo C.; Huidobro-Toro J.Pablo; Scorza, C; Reyes-Parada, M; Cassels, B.K. Article SCOPUS LIFE SCIENCES (2000)
ALEPH-2, a suspected anxiolytic and putative hallucinogenic phenylisopropylamine derivative, is a 5-HT2a and 5-HT2c receptor agonist Acuna-Castillo, C; Scorza, C; Reyes-Parada, M; Cassels, BK; Huidobro-Toro, JP Article ISI LIFE SCIENCES (2000)
ALEPH-2, a suspected anxiolytic and putative hallucinogenic phenylisopropylamine derivative, is a 5-HT2a and 5-HT2c receptor agonist. Acuña-Castillo, C; Scorza, C; Reyes-Parada, M; Cassels, B K; Huidobro-Toro, J P Article Life sciences (2000)
Dopaminergic pharmacology and antioxidant properties of pukateine, a natural product lead for the design of agents increasing dopamine neurotransmission Dajas-Bailador F.A.; bonilla, c; Dajas, F; Asencio M.; Cassels, B.K.; Scorza, M.C.; Echeverry, C; Reyes-Parada, M; Silveira, R.; Protais, P; Russell G. Article General Pharmacology: The Vascular System (1999)
Dopaminergic pharmacology and antioxidant properties of pukateine, a natural product lead for the design of agents increasing dopamine neurotransmission. Dajas-Bailador, F A; Asencio, M; Bonilla, C; Scorza, M C; Echeverry, C; Reyes-Parada, M; Silveira, R; Protais, P; Russell, G; Cassels, B K; Dajas, F Article General pharmacology (1999)
Effects of 5-HT-releasing agents on the extracellullar hippocampal 5-HT of rats. Implications for the development of novel antidepressants with a short onset of action Scorza, C; Silveira, R.; Nichols D.E.; Reyes-Parada, M Article NEUROPHARMACOLOGY (1999)
Effects of 5-HT-releasing agents on the extracellullar hippocampal 5-HT of rats. Implications for the development of novel antidepressants with a short onset of action. Scorza, C; Silveira, R; Nichols, D E; Reyes-Parada, M Article Neuropharmacology (1999)
Effects of the D3 preferring dopamine agonist pramipexole on sleep and waking, locomotor activity and striatal dopamine release in rats Lagos, Patricia; Scorza, Cecilia; Monti, Jaime M; Jantos, Héctor; Reyes Parada, Miguel; Silveira, Rodolfo; Ponzoni, Ana Article EUROPEAN NEUROPSYCHOPHARMACOLOGY (1998)
Effects of the D3 preferring dopamine agonist pramipexole on sleep and waking, locomotor activity and striatal dopamine release in rats. Lagos, P; Scorza, C; Monti, J M; Jantos, H; Reyes-Parada, M; Silveira, R; Ponzoni, A Article European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology (1998)
Aggressive behavior and jamming avoidance response in the weakly electric fish Gymnotus carapo: Effects of 3,4-methylenedioxymethamphetamine (MDMA) Capurro, A.; Reyes-Parada, M; Olazabal, D; Perrone, R.; Silveira, R.; Macadar, O. Article Comparative Biochemistry and Physiology Part A: Physiology (1997)
Monoamine oxidase inhibitory properties of some methoxylated and alkylthio amphetamine derivatives. Structure-activity relationships Scorza, M.C.; Carrau C.; Silveira, R.; Reyes-Parada, M; Zapata-Torres, G; Cassels, B.K. Article BIOCHEMICAL PHARMACOLOGY (1997)
Monoamine oxidase inhibitory properties of some methoxylated and alkylthio amphetamine derivatives: structure-activity relationships. Scorza, M C; Carrau, C; Silveira, R; Zapata-Torres, G; Cassels, B K; Reyes-Parada, M Article Biochemical pharmacology (1997)
(+/-)-1-(2,5-Dimethoxy-4-ethylthiophenyl)-2-aminopropane (ALEPH-2), a novel putative anxiolytic agent lacking affinity for benzodiazepine sites and serotonin-1A receptors. Reyes-Parada, M; Scorza, C; Romero, V; Silveira, R; Medina, J H; Andrus, D; Nichols, D E; Cassels, B K Article Naunyn-Schmiedeberg's archives of pharmacology (1996)
(±)-1-(2,5-dimethoxy-4-ethylthiophenyl)-2-aminopropane (ALEPH-2), a novel putative anxiolytic agent lacking affinity for benzodiazepine sites and serotonin-1A receptors Reyes-Parada, M; Scorza, C; Romero, V; Silveira, R.; Medina, J.H.; Andrus D.; Nichols D.E.; Cassels, B.K. Article NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY (1996)
Behavioral effects of the putative anxiolytic (+/-)-1-(2,5-dimethoxy-4-ethylthiophenyl)-2-aminopropane (ALEPH-2) in rats and mice. Scorza, M C; Reyes-Parada, M; Silveira, R; Viola, H; Medina, J H; Viana, M B; Zangrossi, H; Graeff, F G Article Pharmacology, biochemistry, and behavior (1996)
Behavioral effects of the putative anxiolytic (±)-1-(2,5-dimethoxy-4-ethylthiophenyl)-2-aminopropane (ALEPH-2) in rats and mice Scorza, M.C.; Reyes-Parada, M; Silveira, R.; Viola, H.; Medina, J.H.; Viana, M.B.; Zangrossi, H.; Graeff, F.G. Article Pharmacology Biochemistry and Behavior (1996)
Sleep and waking in 5,7-DHT-lesioned or (-)-pindolol-pretreated rats after administration of buspirone, ipsapirone, or gepirone. Monti, J M; Jantos, H; Silveira, R; Reyes-Parada, M; Scorza, C Article Pharmacology, biochemistry, and behavior (1995)
Sleep and waking in 5,7-DHT-lesioned or (−)-pindolol-pretreated rats after administration of buspirone, ipsapirone, or gepirone Monti, Jaime M; Jantos, Héctor; Silveira, Rodolfo; Reyes Parada, Miguel; Scorza, Cecilia Article Pharmacology Biochemistry and Behavior (1995)
4-Dimethylaminophenethylamine, a sensitive, specific, electrochemically detectable monoamine oxidase-B substrate Reyes Parada, Miguel; Scorza, Ma.Cecilia; Silveira, Rodolfo; Dajas, Federico; Cassels, Bruce K. Article LIFE SCIENCES (1994)
4-Dimethylaminophenethylamine, a sensitive, specific, electrochemically detectable monoamine oxidase-B substrate. Reyes-Parada, M; Scorza, M C; Silveira, R; Dajas, F; Cassels, B K Article Life sciences (1994)
Depletion of brain serotonin by 5,7-DHT: effects on the 8-OH-DPAT-induced changes of sleep and waking in the rat Monti, Jaime M; Jantos, Héctor; Silveira, Rodolfo; Reyes Parada, Miguel; Scorza, Cecilia; Prunell, Giselle Article PSYCHOPHARMACOLOGY (1994)
Depletion of brain serotonin by 5,7-DHT: effects on the 8-OH-DPAT-induced changes of sleep and waking in the rat. Monti, J M; Jantos, H; Silveira, R; Reyes-Parada, M; Scorza, C; Prunell, G Article Psychopharmacology (1994)
Monoamine oxidase inhibitory effects of some 4-aminophenethylamine derivatives Reyes Parada, Miguel; Scorza, Ma.Cecilia; Silveira, Rodolfo; Dajas, Federico; Costa, Gustavo; Tipton, keith F.; Cassels, Bruce K. Article BIOCHEMICAL PHARMACOLOGY (1994)
Monoamine oxidase inhibitory effects of some 4-aminophenethylamine derivatives. Reyes-Parada, M; Scorza, M C; Silveira, R; Dajas, F; Costa, G; Tipton, K F; Cassels, B K Article Biochemical pharmacology (1994)
Serotonergic control of electric organ discharge in Gymnotus carapo. Role of 5-HT2A/2c receptor subtypes Capurro, A.; Reyes-Parada, M; Ardanaz, J.L.; Silveira, R.; Macadar, O. Article Comparative Biochemistry and Physiology Part A: Physiology (1994)
Preliminary voltametric data for the oxidation of 4-methylaminophenethylamine derivatives in buffer and in aprotic solvents Rojas, E; Norambuena E.; OLEA A., C; REYES P., M; Cassels B Article SCIELO BOLETIN DE LA SOCIEDAD CHILENA DE QUIMICA (1993)
CRYSTAL STRUCTURE OF (E)-1-(4-DIMETHYLAMINOPHENYL)-2-NITROPROPENE Brito, Ivan; Manriquez, Victor; REYES P., MIGUEL; CASSELS N., BRUCE; LOPEZ R., MATIAS. Article SCIELO BOLETIN DE LA SOCIEDAD CHILENA DE QUIMICA (1991)


Crystal structure of potassium antimony hexathiodiphosphate, KSbP2S6 MAHN, A; Navarro G.; Zapata, G Abstract ISI ZEITSCHRIFT FUR KRISTALLOGRAPHIE-NEW CRYSTAL STRUCTURES (2005)


Similarities between the binding sites of monoamine oxidase (MAO) from different species. Is zebrafish a useful model for the discovery of novel MAO inhibitors? A. Fierro; A. Montecinos; C. Gómez-Molina; G Núñez; M. Aldeco; D. E. Edmondson; M. Vilches-Herrera; S. Lühr; P. Iturriaga-Vásquez; M. Reyes-Parada; G. R. Baptista BookSection (2013)


Delayed early morning turn ON'' in response to a single dose of levodopa in advanced Parkinson's disease: pharmacokinetics should be considered" Chana, P; Kuntsmann, C; Reyes-Parada, M; Saez-Briones, P EditorialMaterial ISI JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY (2004)


Multisteric drugs: Design of polypharmacological agents that simultaneously interact with monoaminergic proteins and nicotinic receptors, based on similarities between their multiple binding sites Miguel Reyes-Parada; Hernan Pessoa-Mahana Proyecto (2017)
Multisteric drugs=> Design of polypharmacological agents that simultaneously interact with monoaminergic proteins and nicotinic receptors, based on similarities between their multiple binding sites FONDECYT (1170662) Proyecto 2017-2020 Inv. Principal
Synthesis of Novel Indole Derivatives Targeting=> Serotonergic (SERT inhibition /5-HT4 Agonist Activity), Cholinergic (Acetylcholinesterase Inhibition) and β-Amyloid Deposition, in the Search of Multifunctional Agents in Alzheimer´s Disease FONDECYT (1170654) Proyecto 2017-2020 Coinvestigador(a)
“Synthesis of Novel Indole Derivatives Targeting: Serotonergic (SERT inhibition /5 HT4 Agonist Activity), Cholinergic (Acetylcholinesterase Inhibition) and β-Amyloid Deposition, in the Search of Multifunctional Agents in Alzheimer´s Disease Hernan Pessoa-Mahana; Miguel Reyes-Parada Proyecto (2017)
Designing chemical poly-bullets for nicotinic acetylcholine receptors and monoamine transporters (SERT, NET and DAT). A poly- pharmacology approach to understand the nicotine addiction and withdrawal syndrome mediated by multiple receptor targets. Patricio Iturriaga-Vasquez; Miguel Reyes-Parada Proyecto (2015)
DESIGNING CHEMICAL POLY-BULLETS FOR NICOTINIC ACETYLCHOLINE RECEPTORS AND MONOAMINE TRANSPORTERS (SERT, NET AND DAT). A POLY-PHARMACOLOGY APPROACH TO UNDERSTAND THE NICOTINE ADDICTION AND WITHDRAWAL SYNDROME MEDIATED BY MULTIPLE RECEPT FONDECYT (1150615) Proyecto 2015-2019 Coinvestigador(a)
A synthetic approach towards novel series of 3-(3-(1-piperazinyl)propyl-1h-indole derivatives as monoaminergic multi-target agents. Docking studies and pharmacological evaluation at SERT, D2 and MAO-A receptors Hernan Pessioa-Mahana; Miguel Reyes-Parada Proyecto (2013)
A synthetic approach towards novel series of 3-(3-(1-piperazinyl)propyl-1h-indole derivatives as monoaminergic multi-target agents. Docking studies and pharmacological evaluation at SERT, D2 and MAO-A receptors FONDECYT (1130347) Proyecto 2013-2016 Coinvestigador(a)
Fishing for complements: Design of compounds that simultaneously interact with monoaminergic proteins and nicotinic receptors, based on similarities between their ligand binding sites Miguel Reyes-Parada; Patricio Iturriaga-Vasquez Proyecto (2013)
Fishing for complements=> Design of compounds that simultaneously interact with monoaminergic proteins and nicotinic receptors, based on similarities between their ligand binding sites” FONDECYT (1130185) Proyecto 2013-2016 Inv. Responsable
Design, Synthesis and Pharmacological Evaluation of Dual Nicotinic Agonist and MAO-B Inhibitors Activity for Regulation of Dopamine Level in the Brain FONDECYT (1100542) Proyecto 2010-2013 Coinvestigador(a)
Design, Synthesis and Pharmacological Evaluation of Dual Nicotinic Agonist and MAO-B Inhibitors Activity for Regulation of Dopamine Level in the Brain. Patricio Iturriaga-Vasquez; Miguel Reyes-Parada Proyecto (2010)
A Rational Synthetic Approach to 3-Indolealkyl(Aryl)Piperazine Derivatives as New Hetero and Homobivalent Ligands With Potential Serotonergic Activity FONDECYT (1090169) Proyecto 2009-2012 Coinvestigador(a)
A Rational Synthetic Approach to 3-Indolealkyl(Aryl)Piperazine Derivatives as New Hetero and Homobivalent Ligands With Potential Serotonergic Activity Hernan Pessoa-Mahana; Miguel Reyes-Parada Proyecto (2009)
The Monoaminergic "Receptophore". Similarities Among the Active Sites of Monoaminergic Target Proteins, Based on their Crystal Structures: Implications for the Development of Selective and Non-Selective Ligands Miguel Reyes-Parada; Patricio Iturriaga-Vasquez Proyecto (2009)
The Monoaminergic "Receptophore". Similarities Among the Active Sites of Monoaminergic Target Proteins, Based on their Crystal Structures=> Implications for the Development of Selective and Non-Selective Ligands. FONDECYT (1090037) Proyecto 2009-2012 Inv. Responsable
Monoamine Oxidase Inhibitors. Binding Mode, Rational Design, Synthesis and Pharmacological Evaluation Based on the Enzymes Crystal Structures Miguel Reyes-Parada; Patricio Iturriaga-Vasquez Proyecto (2006)
Monoamine Oxidase Inhibitors. Binding Mode, Rational Design, Synthesis and Pharmacological Evaluation Based on the Enzymes Crystal Structures FONDECYT (1060199) Proyecto 2006-2008 Inv. Responsable
Phenethylamine as probes for exploring the MAO active site FONDECYT (1000776) Proyecto 2000-2003 Coinvestigador(a)


Facts and hypotheses about the programming of neuroplastic deficits by prenatal malnutrition Barra, R; Morgan, C; Saez-Briones, P; Reyes-Parada, M; Burgos, H; Morales, B; Hernandez, A Review ISI SCOPUS NUTRITION REVIEWS (2019)
Multiple binding sites in the nicotinic acetylcholine receptors: An opportunity for polypharmacolgy Iturriaga-Vasquez, P; Alzate-Morales, J; Bermudez I.; Varas, R.; Reyes-Parada, M Review ISI SCOPUS Pharmacological Research (2015)

Miguel Reyes

Full Professor

Facultad de Ciencias Médicas

UNIVERSIDAD DE SANTIAGO DE CHILE, FACULTAD DE CIENCIAS MÉDICAS, ESCUELA DE MEDICINA

Santiago, Chile

Angelica Fierro

Associate

Chemistry

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

Ramón Sotomayor

Full Professor

Institute of Physiology

UNIVERSIDAD DE VALPARAÍSO, FACULTAD DE CIENCIAS, DEPARTAMENTO DE FISIOLOGÍA

Valparaíso, Chile

Bruce Cassels

Profesor Titular

Departamento de Química

UNIVERSIDAD DE CHILE, FACULTAD DE CIENCIAS, DEPARTAMENTO DE QUÍMICA

Santiago, Chile

Patricio Iturriaga

Profesor Asociado A

Ciencias Quimicas y Recursos Naturales

UNIVERSIDAD DE LA FRONTERA

Temuco, Chile

Gabriel Nuñez

Jefe de Carrera, Ingeniería Civil Informática

Ciencias Naturales y Tecnología

Universidad de Aysén

Coyhaique, Chile

Pablo Moya

Full Professor

Instituto de Fisiología

Universidad de Valparaiso

Valparaiso, Chile

Gabriel Quiroz

Gerald Zapata

Profesor Asociado

Química Inorgánica y Analítica

Universidad de Chile

Santiago, Chile

Katia Gysling

Professor

Cellular and Molecular Biology

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

Ramiro Araya

Profesor Titular

Universidad de Talca

SantiaTalcago, Chile

Juan González

Pedro Chana Cuevas

Profesor Titular

Facultad de Ciencias Medicas

Universidad de Santiago

Santiago, Chile

Franco Viscarra

JAIME MELLA

PROFESOR ADJUNTO

INSTITUTO DE QUIMICA Y BIOQUIMICA

UNIVERSIDAD DE VALPARAISO

VALPARAISO, Chile

Sebastián Loyola

Académico adjunto

Ciencias de la Salud

Universidad Católica Silva Henriquez

Santiago, Chile

Susan Lühr

Profesor Asistente

Química

Universidad de Chile

Santiago, Chile

Rommy von Bernhardi

Full Professor

Neurology

DEPT. NEUROLOGY, FAC. MEDICINE PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

David Ramirez

Profesor Asistente

Facultad de Ciencias Biológicas

Universidad de Concepción

Concepcion, Chile

Bernardo Morales

Profesor titular

Biologia

Universidad de Santiago de Chile

Santiago, Chile

Paul Silva

Profesor

Química Orgánica y Fisicoquímica

Universidad de Chile

Santiago, Chile

Floria Pancetti

Director de Departamento

Ciencias Biomédicas

UNIVERSIDAD CATOLICA DEL NORTE

Coquimbo, Chile

HERNAN PESSOA

Profesor Asociado

Química Orgánica y Fisicoquímica

UNIVERSIDAD DE CHILE

SANTIAGO, Chile

Cecilia Rojas

Asistente de investigación

Virologia Molecular y Celular

Universidad de Chile

Santiago, Chile

Julio Caballero

Full Professor

Departamento de Bioinformática

Universidad de Talca

Talca, Chile

Jonathan Martínez

Profesor ayudante

UNIVERSIDAD DE VALPARAISO

Valparasiso, Chile

Leandro Zuñiga

Profesor Asociado

Medicine

Universidad de Talca

Talca, Chile

EDWIN PÉREZ

Profesor Asociado

Departamento de Química Orgánica

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

Santiago, Chile

Héctor Burgos

DOCENTE E INVESTIGADOR

FACULTAD DE CIENCIAS

Universidad Mayor, Chile

SANTIAGO, Chile

Cristian Salas

Associate professor

Organic Chemistry

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

Santiago, Chile

Claudio Acuña

Profesosr Asociado

Biología

UNIVERSIDAD DE SANTIAGO DE CHILE

Santiago, Chile

Jorge Campusano

Associate Professor

Cell & Molecular Biology

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

Rafaella Zárate

Investigadora Postdoctoral

Instituto Antofagasta

Universidad de Antofagasta

Antofagasta, Chile

Claudio Coddou

Profesor Asociado

Departamento de Ciencias Biomédicas

Universidad Católica del Norte

Coquimbo, Chile

Georgina Renard

Assistant professor

School of Medicine

Universidad de Santiago de Chile

Santiago, Chile

Maria Forray

PROFESOR ASOCIADO

FARMACIA

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

SANTIAGO, Chile

Rodrigo Varas

Profesor Asociado

Universidad Autónoma de Chile

Talca, Chile

Eduardo Bravo

University of Iowa

Iowa City, Estados Unidos

Ana Martinez

Research Professor

Centro Investigaciones Biológicas (CIB)

Consejo Superior de Investigaciones Científicas (CSIC)

Madrid, Chile

Macarena Gárate

Asistente de investigación

Centro de Investigación Biomédica Aplicada (CIBAP)

Universidad de Santiago de Chile

Santiago, Chile

CLAUDIO SAITZ

Associate Prof.

Organic and Phisycal Chemistry

UNIVERSIDAD DE CHILE-FAC. CS. QUIMICAS Y FARMACEUTICAS

Santiago, Chile

rafael barra

Academico investigador

Escuela de Medicina

universidad de santiago de Chile

Santiago de Chile, Chile

Patricio Rojas

Assistant Professor

Departamento de Biologia

UNIVERSIDAD DE SANTIAGO DE CHILE

Santiago, Chile

Marc Zeise

UNIVERSIDAD DE SANTIAGO DE CHILE

Santiago, Chile

Gonzalo Ugarte

Asistente de Investigación

Biología

UNIVERSIDAD DE SANTIAGO DE CHILE

Santiago, Chile

Nelson Barrera

Associate Professor

Physiology

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

Santiago, Chile

Carlos Pessoa

Profesor Titular

Departamento de Farmacia

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

Wendy Gonzalez

Director of the Center for Bioinformatics, Simulations and Modeling (CBSM)

Bioinformática

CENTRO DE BIOINFORMÁTICA Y SIMULACIÓN MOLECULAR (CBSM)/ UNIVERSIDAD DE TALCA

Talca, Chile

Bárbara Arévalo

Investigador

Investigación

Centro de Estudios de Alimentos Procesados

Talca, Chile

Felipe Moraga

Profesor a Contrata

Departamento de Ciencias Químicas y Recursos Naturales

Universidad de La Frontera

Temuco, Chile

Fanny Guzman

Investigador Senior

Núcleo de Biotecnología Curauma

Pontificia Universidad Católica de Valparaiso

Valparaiso, Chile

Oscar Forero

Investigador

Instituto de Química de Recursos Naturales

Universidad de Talca

Talca, Chile

Samuel Morales

Académico Conferenciante

Universidad de Talca

Talca, Chile

Claudio Coddou

Profesor Asociado

Ciencias Biomédicas

Universidad Católica del Norte

Coquimbo, Chile

Jaime Eugenin

Full Professor

Biology

Universidad de Santiago de Chile

Santiago, Chile

Gabriel Vallejos

Académico

UNIVERSIDAD ASUTRAL DE CHILE

Valdivia, Chile

ANTONIO GALDAMEZ

ASSOCIATE PROFESSOR

CHEMISTRY

DEPARTAMENTO DE QUÍMICA, FACULTAD DE CIENCIA, UNIVERSIDAD DE CHILE

SANTIAGO, Chile

Pablo Moya

Docente de apoyo

Kinesiología

Universidad de

Santiago, Chile

Miguel Reyes Parada

Líneas de Investigación

Educación

Chemist and Pharmacist, UNIVERSIDAD DE CHILE. Chile, 1992

Biological Sciences, Universidad de la República Oriental de Uruguay. Uruguay, 1996

Experiencia Académica

Full professor Full Time

Experiencia Profesional

Full Professor Full Time

Formación de Capital Humano

Article (96)

Abstract (1)

BookSection (1)

EditorialMaterial (1)

Proyecto (19)

Multisteric drugs=> Design of polypharmacological agents that simultaneously interact with monoaminergic proteins and nicotinic receptors, based on similarities between their multiple binding sites

Synthesis of Novel Indole Derivatives Targeting=> Serotonergic (SERT inhibition /5-HT4 Agonist Activity), Cholinergic (Acetylcholinesterase Inhibition) and &#946;-Amyloid Deposition, in the Search of Multifunctional Agents in Alzheimer´s Disease

DESIGNING CHEMICAL POLY-BULLETS FOR NICOTINIC ACETYLCHOLINE RECEPTORS AND MONOAMINE TRANSPORTERS (SERT, NET AND DAT). A POLY-PHARMACOLOGY APPROACH TO UNDERSTAND THE NICOTINE ADDICTION AND WITHDRAWAL SYNDROME MEDIATED BY MULTIPLE RECEPT

A synthetic approach towards novel series of 3-(3-(1-piperazinyl)propyl-1h-indole derivatives as monoaminergic multi-target agents. Docking studies and pharmacological evaluation at SERT, D2 and MAO-A receptors

Fishing for complements=> Design of compounds that simultaneously interact with monoaminergic proteins and nicotinic receptors, based on similarities between their ligand binding sites”

Design, Synthesis and Pharmacological Evaluation of Dual Nicotinic Agonist and MAO-B Inhibitors Activity for Regulation of Dopamine Level in the Brain

A Rational Synthetic Approach to 3-Indolealkyl(Aryl)Piperazine Derivatives as New Hetero and Homobivalent Ligands With Potential Serotonergic Activity

The Monoaminergic "Receptophore". Similarities Among the Active Sites of Monoaminergic Target Proteins, Based on their Crystal Structures=> Implications for the Development of Selective and Non-Selective Ligands.

Monoamine Oxidase Inhibitors. Binding Mode, Rational Design, Synthesis and Pharmacological Evaluation Based on the Enzymes Crystal Structures

Phenethylamine as probes for exploring the MAO active site

Review (2)

Synthesis of Novel Indole Derivatives Targeting=> Serotonergic (SERT inhibition /5-HT4 Agonist Activity), Cholinergic (Acetylcholinesterase Inhibition) and β-Amyloid Deposition, in the Search of Multifunctional Agents in Alzheimer´s Disease