![Man](/images/man.jpg?1721682157)
Miguel Reyes Parada
Full Professor
UNIVERSIDAD DE SANTIAGO DE CHILE, FACULTAD DE CIENCIAS MÉDICAS, ESCUELA DE MEDICINA
Santiago, Chile
Medicinal Chemistry, Pharmacology, Neuropharmacology, Polypharmacology
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Chemist and Pharmacist, UNIVERSIDAD DE CHILE. Chile, 1992
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Biological Sciences, Universidad de la República Oriental de Uruguay. Uruguay, 1996
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Full professor Full Time
UNIVERSIDAD DE SANTIAGO DE CHILE
Ciencias Médicas
Santiago, Chile
1998 - A la fecha
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Full Professor Full Time
Universidad de Santiago de Chile
Santiago, Chile
1998 - A la fecha
- MSc. Thesis in Chemistry, University of Chile. “Synthesis, enantiomeric resolution and evaluation as MAO-inhibitors of 4-methylthio amphetamine and N-alkylated derivatives C. Hurtado-Guzmán. 2001.
- PhD. Thesis in Chemistry, University of Chile. “Synthesis of phenethylamine derivatives as potential MAO-inhibitors”. A. Gallardo-Godoy. 2003.
- PhD. Thesis in Chemistry, University of Santiago de Chile. Quantitative structure-activity relationships of phenethylamine derivatives as potential MAO-inhibitors. A. Fierro. 2007
- PhD. Thesis in Biotechnology, University of Santiago de Chile. “Similarities between the binding sites of monoamine oxidase and the serotonin transporter: a study using mathematical algorithms, molecular simulation and biological assays”. G. Núñez. 2015
- PhD. Thesis in Biotechnology, University of Santiago de Chile. “Determination of similarities between the active sites of monoaminergic proteins and nicotinic receptors: an approach for the rational design of polypharmacological drugs". P. Möller. 2017
Crystal structure of potassium antimony hexathiodiphosphate, KSbP2S6 |
Similarities between the binding sites of monoamine oxidase (MAO) from different species. Is zebrafish a useful model for the discovery of novel MAO inhibitors? |
Delayed early morning turn ON'' in response to a single dose of levodopa in advanced Parkinson's disease: pharmacokinetics should be considered" |
Multisteric drugs: Design of polypharmacological agents that simultaneously interact with monoaminergic proteins and nicotinic receptors, based on similarities between their multiple binding sites |
Multisteric drugs=> Design of polypharmacological agents that simultaneously interact with monoaminergic proteins and nicotinic receptors, based on similarities between their multiple binding sites |
Synthesis of Novel Indole Derivatives Targeting=> Serotonergic (SERT inhibition /5-HT4 Agonist Activity), Cholinergic (Acetylcholinesterase Inhibition) and β-Amyloid Deposition, in the Search of Multifunctional Agents in Alzheimer´s Disease |
“Synthesis of Novel Indole Derivatives Targeting: Serotonergic (SERT inhibition /5 HT4 Agonist Activity), Cholinergic (Acetylcholinesterase Inhibition) and β-Amyloid Deposition, in the Search of Multifunctional Agents in Alzheimer´s Disease |
Designing chemical poly-bullets for nicotinic acetylcholine receptors and monoamine transporters (SERT, NET and DAT). A poly- pharmacology approach to understand the nicotine addiction and withdrawal syndrome mediated by multiple receptor targets. |
DESIGNING CHEMICAL POLY-BULLETS FOR NICOTINIC ACETYLCHOLINE RECEPTORS AND MONOAMINE TRANSPORTERS (SERT, NET AND DAT). A POLY-PHARMACOLOGY APPROACH TO UNDERSTAND THE NICOTINE ADDICTION AND WITHDRAWAL SYNDROME MEDIATED BY MULTIPLE RECEPT |
A synthetic approach towards novel series of 3-(3-(1-piperazinyl)propyl-1h-indole derivatives as monoaminergic multi-target agents. Docking studies and pharmacological evaluation at SERT, D2 and MAO-A receptors |
A synthetic approach towards novel series of 3-(3-(1-piperazinyl)propyl-1h-indole derivatives as monoaminergic multi-target agents. Docking studies and pharmacological evaluation at SERT, D2 and MAO-A receptors |
Fishing for complements: Design of compounds that simultaneously interact with monoaminergic proteins and nicotinic receptors, based on similarities between their ligand binding sites |
Fishing for complements=> Design of compounds that simultaneously interact with monoaminergic proteins and nicotinic receptors, based on similarities between their ligand binding sites” |
Design, Synthesis and Pharmacological Evaluation of Dual Nicotinic Agonist and MAO-B Inhibitors Activity for Regulation of Dopamine Level in the Brain |
Design, Synthesis and Pharmacological Evaluation of Dual Nicotinic Agonist and MAO-B Inhibitors Activity for Regulation of Dopamine Level in the Brain. |
A Rational Synthetic Approach to 3-Indolealkyl(Aryl)Piperazine Derivatives as New Hetero and Homobivalent Ligands With Potential Serotonergic Activity |
A Rational Synthetic Approach to 3-Indolealkyl(Aryl)Piperazine Derivatives as New Hetero and Homobivalent Ligands With Potential Serotonergic Activity |
The Monoaminergic "Receptophore". Similarities Among the Active Sites of Monoaminergic Target Proteins, Based on their Crystal Structures: Implications for the Development of Selective and Non-Selective Ligands |
The Monoaminergic "Receptophore". Similarities Among the Active Sites of Monoaminergic Target Proteins, Based on their Crystal Structures=> Implications for the Development of Selective and Non-Selective Ligands. |
Monoamine Oxidase Inhibitors. Binding Mode, Rational Design, Synthesis and Pharmacological Evaluation Based on the Enzymes Crystal Structures |
Monoamine Oxidase Inhibitors. Binding Mode, Rational Design, Synthesis and Pharmacological Evaluation Based on the Enzymes Crystal Structures |
Phenethylamine as probes for exploring the MAO active site |
Facts and hypotheses about the programming of neuroplastic deficits by prenatal malnutrition |
Multiple binding sites in the nicotinic acetylcholine receptors: An opportunity for polypharmacolgy |
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Miguel Reyes
Full Professor
Facultad de Ciencias Médicas
UNIVERSIDAD DE SANTIAGO DE CHILE, FACULTAD DE CIENCIAS MÉDICAS, ESCUELA DE MEDICINA
Santiago, Chile
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Ramón Sotomayor
Full Professor
Institute of Physiology
UNIVERSIDAD DE VALPARAÍSO, FACULTAD DE CIENCIAS, DEPARTAMENTO DE FISIOLOGÍA
Valparaíso, Chile
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Bruce Cassels
Profesor Titular
Departamento de Química
UNIVERSIDAD DE CHILE, FACULTAD DE CIENCIAS, DEPARTAMENTO DE QUÍMICA
Santiago, Chile
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Patricio Iturriaga
Profesor Asociado A
Ciencias Quimicas y Recursos Naturales
UNIVERSIDAD DE LA FRONTERA
Temuco, Chile
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Gabriel Nuñez
Jefe de Carrera, Ingeniería Civil Informática
Ciencias Naturales y Tecnología
Universidad de Aysén
Coyhaique, Chile
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Katia Gysling
Professor
Cellular and Molecular Biology
PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE
Santiago, Chile
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Pedro Chana Cuevas
Profesor Titular
Facultad de Ciencias Medicas
Universidad de Santiago
Santiago, Chile
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Floria Pancetti
Director de Departamento
Ciencias Biomédicas
UNIVERSIDAD CATOLICA DEL NORTE
Coquimbo, Chile
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HERNAN PESSOA
Profesor Asociado
Química Orgánica y Fisicoquímica
UNIVERSIDAD DE CHILE
SANTIAGO, Chile
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JAIME MELLA
PROFESOR ADJUNTO
INSTITUTO DE QUIMICA Y BIOQUIMICA
UNIVERSIDAD DE VALPARAISO
VALPARAISO, Chile
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Sebastián Loyola
Académico Investigador
Ciencias de la Salud
Universidad Católica Silva Henriquez
Santiago, Chile
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David Ramirez
Profesor Asistente
Facultad de Ciencias Biológicas
Universidad de Concepción
Concepcion, Chile
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Rommy von Bernhardi
Full Professor
Neurology
DEPT. NEUROLOGY, FAC. MEDICINE PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE
Santiago, Chile
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Cecilia Rojas
Asistente de investigación
Virologia Molecular y Celular
Universidad de Chile
Santiago, Chile
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Rafaella Zárate
Investigadora Postdoctoral
Instituto Antofagasta
Universidad de Antofagasta
Antofagasta, Chile
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EDWIN PÉREZ
Profesor Asociado
Departamento de Química Orgánica
PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE
Santiago, Chile
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Cristian Salas
Associate professor
Organic Chemistry
PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE
Santiago, Chile
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Jorge Campusano
Associate Professor
Cell & Molecular Biology
PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE
Santiago, Chile
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Georgina Renard
Assistant professor
School of Medicine
Universidad de Santiago de Chile
Santiago, Chile
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Claudio Coddou
Profesor Asociado
Departamento de Ciencias Biomédicas
Universidad Católica del Norte
Coquimbo, Chile
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Ana Martinez
Research Professor
Centro Investigaciones Biológicas (CIB)
Consejo Superior de Investigaciones Científicas (CSIC)
Madrid, Chile
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Macarena Gárate
Asistente de investigación
Centro de Investigación Biomédica Aplicada (CIBAP)
Universidad de Santiago de Chile
Santiago, Chile
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rafael barra
Academico investigador
Escuela de Medicina
universidad de santiago de Chile
Santiago de Chile, Chile
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CLAUDIO SAITZ
Associate Prof.
Organic and Phisycal Chemistry
UNIVERSIDAD DE CHILE-FAC. CS. QUIMICAS Y FARMACEUTICAS
Santiago, Chile
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Carlos Pessoa
Profesor Titular
Departamento de Farmacia
PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE
Santiago, Chile
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Patricio Rojas
Assistant Professor
Departamento de Biologia
UNIVERSIDAD DE SANTIAGO DE CHILE
Santiago, Chile
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Nelson Barrera
Associate Professor
Physiology
PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE
Santiago, Chile
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Wendy Gonzalez
Director of the Center for Bioinformatics, Simulations and Modeling (CBSM)
Bioinformática
CENTRO DE BIOINFORMÁTICA Y SIMULACIÓN MOLECULAR (CBSM)/ UNIVERSIDAD DE TALCA
Talca, Chile
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Felipe Moraga
Profesor a Contrata
Departamento de Ciencias Químicas y Recursos Naturales
Universidad de La Frontera
Temuco, Chile
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Fanny Guzman
Investigador Senior
Núcleo de Biotecnología Curauma
Pontificia Universidad Católica de Valparaiso
Valparaiso, Chile
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Oscar Forero
Investigador
Instituto de Química de Recursos Naturales
Universidad de Talca
Talca, Chile
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ANTONIO GALDAMEZ
ASSOCIATE PROFESSOR
CHEMISTRY
DEPARTAMENTO DE QUÍMICA, FACULTAD DE CIENCIA, UNIVERSIDAD DE CHILE
SANTIAGO, Chile