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Nelson Patricio Barrera Rojas

Associate Professor

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

Santiago, Chile

Membrane Protein structure and function, Membrane Protein Structure by Atomic Force Microscopy, Membrane Protein Structure by Mass Spectrometry, Signal transduction of membrane proteins, Receptor Cross-talk, Single-molecule events, Nanophysiology

Biochemistry, PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE. Chile, 1997
Biochemistry, PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE. Chile, 1999
Biological Sciences with major in Physiology, PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE. Chile, 2004

Assistant Professor Full Time

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

Biological Sciences

Santiago, Chile

2009 - 2018
Visiting Professor Other

UNIVERSITY OF OXFORD

Oxford, Reino Unido

2011 - 2011
Research Associate Other

UNIVERSITY OF CAMBRIDGE

Cambridge, Reino Unido

2004 - 2007
Research Associate Other

UNIVERSITY OF CAMBRIDGE

Cambridge, Reino Unido

2007 - 2009
Associate Professor Full Time

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

Biological Sciences

Chile

2018 - A la fecha

Assistant Professor Full Time

Pontificia Universidad Católica de Chile

Santiago, Chile

2009 - 2018
Associate Professor Full Time

Pontificia Universidad Católica de Chile

Santiago, Chile

2018 - A la fecha

Undergraduate and Master Thesis (in Progress)

José Cordero, BSc in Biochemistry, Title ‘AFM applications on cellular and molecular biomechanics’. Pontificia Universidad Católica de Chile. Since September 2017.

Graciela Bravo, BSc in Biochemistry, Title ‘Effect of magnetic nanorods on cellular morphology’. Pontificia Universidad Católica de Chile. Since August 2017. (co-tutor)

Christian Fuentes, Mac in Physics, Title 'Studies of P2X4 receptor dynamics upon agonist activation by High-Speed Atomic Force Microscopy and Molecular Dynamics simulations'. Pontificia Universidad Católica de Chile. Since August 2017.

Thesis (Finished)

Gabriel Olguín, BSc in Bioinformatics, Title ‘Molecular dynamics simulations on IgG1 adsorption onto kaolinite surface’. Universidad de Talca. October 2017.

Camila Cárdenas, BSc in Biochemistry, Title ‘Characterization of the interaction between P2X2 receptor and alpha-[2-Azidoetil]-ATP via AFM and patch-clamp'. Pontificia Universidad Católica de Chile. March 2016.

Eduardo Santander, BSc in Biochemistry and Pharmacy, Title ‘AFM application on adsorption of membrane proteins'. Pontificia Universidad Católica de Chile. March 2015.

PhD Thesis in Progress

Nicole Morales, PhD(c) in Biological Sciences, major Physiology, Title ‘Biomechanical characterization of the NET-endothelium interaction’. Pontificia Universidad Católica de Chile. Since July 2016.

Paola Soto, PhD(c) in Biological Sciences, major Physiology, Title ‘AFM determination of the crosstalk between 5HT3A and P2X2 receptors'. Pontificia Universidad Católica de Chile. Since September 2014.

Post-Doctoral Supervision

Pamela Naulin, Title ‘Molecular architecture of heteromeric Cx26/Cx30 hemichannels’. From November 2015 until November 2018, FONDECYT Postdoctoral (Sponsor Dr. Nelson Barrera)

Pablo Gaete, Title ‘Molecular regulation of the pannexin-1 in endothelial cells’. From November 2015 until November 2018, FONDECYT Postdoctoral (Sponsor Dr. Nelson Barrera)

Karla Droguett, Title ‘Biomechanical properties of the respiratory epithelium induced by pro-immflamatory processes'. Since November 2014 until November 2017, FONDECYT Postdoctoral (Sponsor Dr. Nelson Barrera)

Gean Carlos Arteaga, Title ‘Synthesis of P2X2 receptor ligands for single molecule force spectroscopy measurements’. Since January 2014 until December 2014, PUC Interdisciplinary Postdoctoral (Co-Sponsor Dr. Nelson Barrera)

Andrea Gómez, Title ‘Structural analysis of the LHC complex’. Since November 2013 until November 2016, FONDECYT Postdoctoral (Sponsor Dr. Nelson Barrera)

Outstanding Contribution Award

UNIVERSITY OF CAMBRIDGE

Reino Unido, 2008

Work on Mass spectrometry of membrane proteins at the laboratory of Carol Robinson
Isaac Newton Institute Award

ISAAC NEWTON INSTITUTE

Reino Unido, 2007

Participación en workshop ‘Effective Computational Methods for Highly Oscillatory Problems: The Interplay between Mathematical Theory and Applications


Crosstalking interactions between P2X4 and 5-HT3A receptors Chang-Halabi, Yuan; Sarabia, Xander; Villalobos, Daniela; Barrera, Nelson P. Article ISI NEUROPHARMACOLOGY (2023)
Fractional Factorial Design to Evaluate the Synthesis and Electrochemical Transfer Parameters of h-BN Coatings Figueroa, Helen; Barrera, Nelson P. Article ISI NANOMATERIALS (2023)
Nanoscale Dynamics of Streptococcal Adhesion to AGE-Modified Collagen Tiozzo-Lyon, P.; Robles, A. I.; Barrera, N. P. Article ISI JOURNAL OF DENTAL RESEARCH (2023)
Drug-dependent inhibition of nucleotide hydrolysis in the heterodimeric ABC multidrug transporter PatAB from <i>Streptococcus pneumoniae</i> Guffick, Charlotte; Hsieh, Pei-Yu; Ali, Anam; Shi, Wilma; Howard, Julie; Chinthapalli, Dinesh K.; Kong, Alex C.; Salaa, Ihsene; Crouch, Lucy, I; Ansbro, Megan R.; et al. Article ISI FEBS JOURNAL (2022)
How far are we from predicting multi-drug interactions during treatment for COVID-19 infection? Santibanez, Javier; Retamal, Jaime; Barrera, Nelson P. Article ISI BRITISH JOURNAL OF PHARMACOLOGY (2022)
Nanomechanical and Molecular Characterization of Aging in Dentinal Collagen Leiva-Sabadini, C.; Barrera, N. P. Article ISI JOURNAL OF DENTAL RESEARCH (2022)
Ultrastructural characterisation of young and aged dental enamel by atomic force microscopy Barrera, Nelson P. Article ISI JOURNAL OF MICROSCOPY (2022)
Antibacterial Effect of Honey-Derived Exosomes Containing Antimicrobial Peptides Against Oral Streptococci Barrera, Nelson P. Article ISI INTERNATIONAL JOURNAL OF NANOMEDICINE (2021)
Initial adhesion suppression of biofilm-forming and copper-tolerant bacterium Variovorax sp. on laser microtextured copper surfaces Caro-Lara, Luis; Ramos-Moore, Esteban; Vargas, Ignacio T; Walczak, Magdalena; Barrera, Nelson P.; Pizarro, Gonzalo Article ISI COLLOIDS AND SURFACES B-BIOINTERFACES (2021)
Modulatory Effect of Glycated Collagen on Oral Streptococcal Nanoadhesion Naulin, P. A.; Barrera, N. P. Article ISI JOURNAL OF DENTAL RESEARCH (2021)
Activation of P2X4 receptors induces an increase in the area of the extracellular region and a decrease in receptor mobility Bergler, Frederik; Navarrete, Camilo; Supple, Jack; Barrera, Nelson P.; Edwardson, John Michael Article ISI FEBS LETTERS (2020)
Function of P2X4 Receptors Is Directly Modulated by a 1:1 Stoichiometric Interaction With 5-HT(3)A Receptors Barrera Nelson, Patricio Article ISI FRONTIERS IN CELLULAR NEUROSCIENCE (2020)
Live endothelial cells on plasma-nitrided and oxidized titanium: An approach for evaluating biocompatibility Barrera, Nelson P. Article ISI Materials Science and Engineering: C (2020)
Polydisperse molecular architecture of connexin 26/30 heteromeric hemichannels revealed by atomic force microscopy imaging Schmidt, Carla; Barrera, Nelson P. Article ISI JOURNAL OF BIOLOGICAL CHEMISTRY (2020)
Type I collagen hydrogels as a delivery matrix for royal jelly derived extracellular vesicles Ramirez, Orlando J.; Alvarez, Simon; Barrera, Nelson P.; Aguayo, Sebastian Article ISI DRUG DELIVERY (2020)
Inhibition of Wild Enterobacter cloacae Biofilm Formation by Nanostructured Graphene- and Hexagonal Boron Nitride-Coated Surfaces Zurob, Elsie; Gentil, Dana; Gerber, Ulrike; Naulin, Pamela; Gomez, Andrea; Lascano, Sheila; Rodrigues da Cunha, Thiago Henrique; Ramirez, Cristian; Barrera, Nelson; Wilkens, Marcela Article ISI SCOPUS NANOMATERIALS (2019)
Nanoscale Mobility of the Apo State and TARP Stoichiometry Dictate the Gating Behavior of Alternatively Spliced AMPA Receptors Dawe, G. Brent; Kadir, Md. Fahim; Venskutonyt?, Raminta; Perozzo, Amanda M.; Yan, Yuhao; Alexander, Ryan P.D.; Navarrete, Camilo; Santander, Eduardo A.; Arsenault, Marika; Aurousseau, Mark R.P.; et al. Article ISI SCOPUS NEURON (2019)
Structural characterization of the saxitoxin-targeting APTSTX1 aptamer using optical tweezers and molecular dynamics simulations Alfaro, Karol; Montenegro, Felipe; Barrera, Nelson P.; Maze, J. R.; Wilson, Christian A. M.; Conejeros, Pablo; Dague, Etienne Article SCOPUS PLOS ONE (2019)
An autocrine ATP release mechanism regulates basal ciliary activity in airway epithelium Droguett, Karla; Fuentes, Christian Article ISI SCOPUS JOURNAL OF PHYSIOLOGY-LONDON (2017)
Combining Mass Spectrometry and X-Ray Crystallography for Analyzing Native-Like Membrane Protein Lipid Complexes Montenegro, Felipe A.; Cantero, Jorge R. Article ISI SCOPUS FRONTIERS IN PHYSIOLOGY (2017)
Modified Electrodes with Polymers Based on Aniline and Thiophene: Characterization and Possible Use as a Sensor Shultz, S Article ISI SCOPUS INTERNATIONAL JOURNAL OF ELECTROCHEMICAL SCIENCE (2017)
P2X4 Receptor in Silico and Electrophysiological Approaches Reveal Insights of Ivermectin and Zinc Allosteric Modulation Godoy, Francisca; Barrera, Nelson P. Article ISI SCOPUS FRONTIERS IN PHARMACOLOGY (2017)
Study of the Ultrastructure of Eucalyptus globulus Wood Substrates Subjected to Auto-Hydrolysis and Diluted Acid Hydrolysis Pre-treatments and Its Influence on Enzymatic Hydrolysis Arévalo, Cristian; Naulin, Pamela A.; Peña-Farfal, Carlos; del P. Castillo, Rosario Article ISI SCOPUS BIOENERGY RESEARCH (2017)
Low physiological levels of prostaglandins E-2 and F-2 improve human sperm functions Rios M.; Carreno, DV; Oses, C; Barrera, N; Kerr, B.; Villalón M. Article ISI SCOPUS REPRODUCTION FERTILITY AND DEVELOPMENT (2016)
Structural model of FeoB, the iron transporter from Pseudomonas aeruginosa, predicts a cysteine lined, GTP-gated pore Seyedmohammad, S.; Fuentealba, N. A.; Marriott, R. A. J.; Goetze, T. A.; Edwardson, J. M.; Barrera, N. P.; Venter, H. Article SCOPUS Bioscience Reports (2016)
Toward atomic force microscopy and mass spectrometry to visualize and identify lipid rafts in plasmodesmata Naulin, PA; Alveal, NA; Barrera, NP Article ISI SCOPUS FRONTIERS IN PLANT SCIENCE (2014)
alpha-Amino-3-hydroxy-5-methyl-4-isoxazole Propionic Acid (AMPA) and N-Methyl-D-aspartate (NMDA) Receptors Adopt Different Subunit Arrangements Balasuriya, D; Goetze, TA; Barrera, NP; Stewart, AP; Suzuki Y.; Edwardson, JM Article ISI SCOPUS Journal of Biological Chemistry (2013)
Mass Spectrometry-From Peripheral Proteins to Membrane Motors Morgner, N; Montenegro, F; Barrera, N. P. Article ISI SCOPUS Journal of Molecular Biology (2012)
Evidence for the Assembly of a Bacterial Tripartite Multidrug Pump with a Stoichiometry of 3:6:3 Janganan, TK; Bavro, VN; Zhang, L; Matak-Vinkovic D.; Barrera, NP; Venien-Bryan C.; Robinson, CV; Borges-Walmsley, MI; Walmsley, AR Article ISI SCOPUS Journal of Biological Chemistry (2011)
Imaging the spatial orientation of subunits within membrane receptors by atomic force microscopy. Carnally S.M.; Edwardson, J. M.; Barrera, N. P. Article SCOPUS METHODS IN MOLECULAR BIOLOGY (CLIFTON, N.J.) (2011)
Mass Spectrometry of Intact V-Type ATPases Reveals Bound Lipids and the Effects of Nucleotide Binding Zhou, M.; Morgner, N; Barrera, NP; Politis, A; Isaacson, SC; Matak-Vinkovic D.; Murata, T; Bernal, RA; Stock, D; Robinson, CV Article ISI SCOPUS Science (2011)
Opening of the Outer Membrane Protein Channel in Tripartite Efflux Pumps Is Induced by Interaction with the Membrane Fusion Partner Janganan, TK; Zhang, L; Bavro, VN; Barrera, NP; Burton, MF; Steel, PG; Robinson, CV; Walmsley, AR Article ISI JOURNAL OF BIOLOGICAL CHEMISTRY (2011)
Ion Mobility Mass Spectrometry of Two Tetrameric Membrane Protein Complexes Reveals Compact Structures and Differences in Stability and Packing Wang, SC; Politis, A; Di Bartolo, N; Bavro, VN; Tucker, SJ; Booth, PJ; Barrera, NP; Robinson, CV Article ISI SCOPUS Journal of the American Chemical Society (2010)
MDMA ("ecstasy") impairs learning in the Morris Water Maze and reduces hippocampal LTP in young rats Arias-Cavieres, A; Rozas C.; Reyes-Parada, M; Barrera, N; Pancetti F.; Loyola S; Lorca RA; Morales, B Article ISI SCOPUS Neuroscience Letters (2010)
Separating and visualisiing protein assemblies by means of preparative mass spectrometry and microscopy Benesch, JLP; Ruotolo, BT; Simmons, DA; Barrera, NP; Morgner, N; Wang, LC; Helen, R; Robinson, CV Article ISI JOURNAL OF STRUCTURAL BIOLOGY (2010)
A Multidrug ABC Transporter with a Taste for Salt Velamakanni, Saroj; Lau, Calvin H. F.; Gutmann, Daniel A. P.; Venter, Henrietta; Seeger, Markus A.; Woebking, Barbara; Matak-Vinkovic, Dijana; Balakrishnan, Lekshmy; Yao, Yao; U, Edmond C. Y.; et al. Article PLOS ONE (2009)
MacB ABC Transporter Is a Dimer Whose ATPase Activity and Macrolide-binding Capacity Are Regulated by the Membrane Fusion Protein MacA Lin, H. T.; Bavro, V. N.; Frankish, H. M.; Velamakanni, S.; van Veen, H. W.; Robinson, C. V.; Borges-Walmsley, M. I.; Walmsley, A. R. Article JOURNAL OF BIOLOGICAL CHEMISTRY (2009)
Mass spectrometry of membrane transporters reveals subunit stoichiometry and interactions Isaacson, Shoshanna C; Zhou, Min; Bavro, Vassiliy N; Welch, Alex; Schaedler, Theresia A; Miguel, Ricardo Núñez; Korkhov, Vladimir M; Venter, Henrietta; Walmsley, Adrian R; Tate, Christopher G Article NATURE METHODS (2009)
Atomic Force Microscopy Reveals the Stoichiometry and Subunit Arrangement of the 4 3 GABAA Receptor Barrera, N. P.; Edwardson, J. M. Article ISI Molecular Pharmacology (2008)
Automated analysis of the architecture of receptors, imaged by atomic force microscopy Ge, Haifang; Henderson, Robert M.; Fitzgerald, William J.; Edwardson, J. Michael Article Micron (2008)
Determination of the architecture of ionotropic receptors using AFM imaging Henderson, Robert M.; Edwardson, J. Michael Article PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY (2008)
Direct visualization of the trimeric structure of the ASIC1a channel, using AFM imaging Carnally, Stewart M.; Dev, Harveer S.; Stewart, Andrew P.; Van Bemmelen, Miguel X.; Schild, Laurent; Henderson, Robert M.; Edwardson, J.Michael Article Biochemical and Biophysical Research Communications (2008)
Micelles Protect Membrane Complexes from Solution to Vacuum Booth, P. J.; Robinson, C. V. Article SCIENCE (2008)
Providing unique insight into cell biology via atomic force microscopy Victor Shahin; Nelson P. Barrera Article Int. Rev. Cytol. (2008)
The subunit arrangement and assembly of ionotropic receptors Edwardson, J. Michael Article Trends in Neurosciences (2008)
AFM imaging reveals the tetrameric structure of the TRPC1 channel Shaifta, Yasin; McFadzean, Ian; Ward, Jeremy P.T.; Henderson, Robert M.; Edwardson, J. Michael Article Biochemical and Biophysical Research Communications (2007)
ATP and adenosine trigger the interaction of plasma membrane IP3 receptors with protein kinase A in oviductal ciliated cells Barrera, NP; Morales, B; Villalón M. Article ISI SCOPUS BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2007)
The Stoichiometry of P2X2/6 Receptor Heteromers Depends on Relative Subunit Expression Levels Henderson, Robert M.; Murrell-Lagnado, Ruth D.; Edwardson, J. Michael Article BIOPHYSICAL JOURNAL (2007)
An Uncharged Region within the N-Terminus of the P2X6 Receptor Inhibits Its Assembly and Exit from the Endoplasmic Reticulum Ormond, Susan J.; Qureshi, Omar S.; Henderson, Robert M.; Edwardson, J. Michael; Murrell-Lagnado, Ruth D. Article Web of Science, Scopus Molecular Pharmacology (2006)
Class of skew-distributions: Theory and applications in biology Barrera, NP; Galea M.; Torres, S.; Villalón M. Article ISI SCOPUS STATISTICS (2006)
Atomic Force Microscopy Imaging Demonstrates that P2X2 Receptors Are Trimers but That P2X6 Receptor Subunits Do Not Oligomerize Barrera, N. P.; Ormond, S. J.; Murrell-Lagnado, R. D.; Edwardson, J. M. Article ISI JOURNAL OF BIOLOGICAL CHEMISTRY (2005)
Atomic force microscopy reveals the stoichiometry and subunit arrangement of 5-HT3 receptors Herbert, P.; Henderson, R. M.; Martin, I. L. Article PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)
Plasma and intracellular membrane inositol 1,4,5-trisphosphate receptors mediate the Ca2+ increase associated with the ATP-induced increase in ciliary beat frequency Barrera, NP; Morales, B; Villalón M. Article ISI SCOPUS AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY (2004)
Prediction of synergism on frequency of responses in the attojoule range Barrera, NP; Torres, S.; Morales, B; Villalón M. Article ISI SCOPUS PHYSICAL CHEMISTRY CHEMICAL PHYSICS (2004)
Platelet activating factor increases ciliary activity in the hamster oviduct through epithelial production of prostaglandin E-2 Hermoso, M; Barrera, N; Morales, B; Pérez S.; Villalón M. Article ISI PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY (2001)
Platelet activating factor increases ciliary activity in the hamster oviduct through epithelial production of prostaglandin E2 Hermoso, M; Barrera, N; Morales, B; Villalón M.; Pérez S. Article SCOPUS PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY (2001)
Functional cross talk after activation of P2 and P1 receptors in oviductal ciliated cells Morales, B; Barrera, N; Uribe, P; Mora, C.; Villalón M. Article ISI SCOPUS AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY (2000)


Regulation of Pannexin-1 Channel Gating by Nitric Oxide and Camp Signaling Gaete, PS; Lillo, MA; Barrera, NP; Contreras, JE Abstract ISI BIOPHYSICAL JOURNAL (2019)
Combined in silico plus electrophysiological studies identify molecular determinants of ivermectin and zinc P2X4R allosterism Latapiat, V; Barrera, N Abstract ISI (2018)
Atomic Force Microscopy Imaging Reveals Structural and Mechanical Properties of Dissociated Hemocyanins by Temperature Navarrete C.; Villar, J; Aguilar, Y; Cabrera, R; Barrera, NP Abstract ISI BIOPHYSICAL JOURNAL (2014)
Basal ciliary activity depends on ATP release in respiratory epithelium of mouse trachea Droguett, K; Barrera, N Abstract ISI ACTA PHYSIOLOGICA (2014)
Structural analysis of the P2X4 receptor reveals insights of the mechanism of allosteric regulation by alfaxolone Huidobro-Toro, JP; Alveal N.; Navarrete C.; Barrera, N Abstract ISI PURINERGIC SIGNALLING (2014)
Structural Studies of Heteromeric Connexin26/30 Hemichannels via Atomic Force Microscopy Imaging Naulin, PA; Liu Y.; Harris, AL; Contreras, JE; Barrera, NP Abstract ISI BIOPHYSICAL JOURNAL (2014)
Combined Mass Spectrometry and Molecular Dynamics to Study Membrane Protein Stability in Gas Phase Montenegro, F; BARRERA, M; Alveal N.; Cantero J.; Brugues, G; Barrera, NP Abstract ISI BIOPHYSICAL JOURNAL (2013)
Single Molecule Cross-Talk Transferred from a Molecular Event to an Organ Function Barrera, NP Abstract ISI BIOPHYSICAL JOURNAL (2012)
A physical chemistry theory of synergism on ciliated cell motility Barrera, N; Morales, B; Villalón M. Abstract ISI BIOPHYSICAL JOURNAL (2002)
Synergism on ciliary activity induced by ATP and adenosine depends on a reciprocal modulation of their transduction pathways Morales, B; Barrera, N; Villalón M. Abstract ISI BIOPHYSICAL JOURNAL (2002)
Arachidonic acid is a mediator of the increase on ciliary activity induced by PAF in hamster oviductal epithelium. Barrera, N Abstract ISI BIOLOGY OF REPRODUCTION (2001)
Transduction mechanisms associated with activation of P-1 and P-2 purinoceptors in oviductal ciliated cells: functional cross-talk between both pathways Barrera, N; Morales, B Abstract ISI JOURNAL OF PHYSIOLOGY-LONDON (2000)


Providing Unique Insight into Cell Biology via Atomic Force Microscopy Shahin, Victor; Jeon, Kwang W. BookSection (2008)
Reciprocal Synergism at Early Stages of Transduction Pathways Allows Efficient Cell Signalling Yanson, Bruce R. BookSection (2007)


Correlative High-Speed BioAFM to reveal combined nanomechanical properties and quantitative imaging from single molecule to biological tissues Barrera, Nelson P. Proyecto (2023)
Desarrollo de una plataforma fármaco-proteómica para evaluar potenciales interacciones farmacológicas y su impacto clínico en pacientes trasplantados hepáticos en tratamiento multidroga Barrera, Nelson P. Proyecto (2023)
Combining force spectroscopy and cellular omics reveals the molecular mechanism of crosstalking interaction between plasma membrane P2X4 and 5-HT3a receptors Barrera, Nelson P. Proyecto (2021)
New understanding of the endothelium-dependent control of vascular function by the emergence of voltage-dependent Na+ channels in endothelial cell signaling Barrera, Nelson P. Proyecto (2021)
Centro de Espectrometria de masas de alta resolución en omics y complejos intactos Proyecto (2017)
Aplicación de Espectrometría de Masas de Alta Resolución para potenciar estudios interdisciplinarios de proteómica, biología estructural y biomedicina=> desde péptidos hasta complejos supramoleculares intactos FONDEQUIP (EQM150102) Proyecto 2016-2017 Inv. Responsable
Desarrollo de un metodo integrado de medicion de las propiedades biomecanicas de celulas vivas y biomateriales=> una nueva aproximacion para evaluar biocompatibilidad FONDEF (ID15I10475) Proyecto 2016-2018 Director(a)
CONTROL AND COORDINATION OF MICROVASCULAR VASOMOTOR TONE BY NITRIC OXIDE-DEPENDENT REGULATION OF CONNEXIN- AND PANNEXIN-FORMED GAP JUNCTION CHANNELS OR HEMICHANNELS FONDECYT (1150530) Proyecto 2015-2019 Coinvestigador(a)
Determinación de la arquitectura molecular y funcional de los hemicanales de conexinas heteromericas Cx26/Cx30 FONDECYT (3160568) Proyecto 2015-2018 Inv. Patrocinante
High-Speed Analysis of Cross-Talk between Neurotransmitter-Gated Channels PCI (20140080) Proyecto 2015-2017 Inv. Responsable
Regulacion molecular de las dinamicas de apertura del canal formado por Panexina-1 en la celula endotelial=> La respuesta gatillada por CGRP FONDECYT (3160348) Proyecto 2015-2018 Inv. Patrocinante
PROCESOS PRO-INFLAMATORIOS MODIFICAN LAS PROPIEDADES BIOMECÃ�NICAS CELULARES QUE REGULAN EL TRANSPORTE MUCOCILIAR EN EL EPITELIO RESPIRATORIO FONDECYT (3150652) Proyecto 2014-2017 Inv. Patrocinante
ANALISIS ESTRUCTURAL DEL COMPLEJO MODIFICADOR DE CROMATINA LHC MEDIANTE ESPECTROMETRIA DE MASA Y MICROSCOPIA DE FUERZA ATOMICA. FONDECYT (3140475) Proyecto 2013-2016 Inv. Patrocinante
Nano-devices for high precision measurements in biology and nano structured materials for biomedicine PIA (ACT-1108) Proyecto 2012-2015 Investigador(a)
Single molecule pharmacology of P2X receptors by atomic force microscopy FONDECYT (1120169) Proyecto 2012-2016 Inv. Responsable
The Membrane Protein Structural Biology Millennium Nucleus ICM (P10-035F) Proyecto 2011-2014 Director(a)
Role of detergent micelles on the stoichiometry of intact membrane proteins in the gas phase FONDECYT (1100515) Proyecto 2010-2012 Inv. Responsable
Dynamic multiprotein complexes-insights from mass spectrometry The Wellcome Trust (088150/Z/09/Z) Proyecto 2009-2014 Inv. Principal


Vas deferens neuro-effector junction: From kymographic tracings to structural biology principles Navarrete, LC; Barrera, NP; Huidobro-Toro, JP Review ISI SCOPUS AUTONOMIC NEUROSCIENCE-BASIC & CLINICAL (2014)
The role of lipids in defining membrane protein interactions: insights from mass spectrometry Barrera, NP; Zhou, M.; Robinson, CV Review ISI SCOPUS Trends in Cell Biology (2013)
Advances in the Mass Spectrometry of Membrane Proteins: From Individual Proteins to Intact Complexes Barrera, NP; Robinson, CV Review ISI SCOPUS Annual Review of Biochemistry (2011)
Principles: Mechanisms and modeling of synergism in cellular responses Barrera, NP; Morales, B; Torres, S.; Villalón M. Review ISI SCOPUS TRENDS IN PHARMACOLOGICAL SCIENCES (2005)

CARLOS PEÑA

PROFESOR

INSTITUTO DE CIENCIAS QUIMICAS APLICADAS

Universidad Autónoma de Chile

TEMUCO, Chile

Marcela Hermoso

Full Professor

School of Medicine

UNIVERSIDAD DE CHILE

Santiago, Chile

Xavier Figueroa

Associate Professor

Departamento de Fisiologia

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

Ricardo Cabrera

Assitant Pofessor

Biology

UNIVERSIDAD DE CHILE

Santiago, Chile

Floria Pancetti

Director de Departamento

Ciencias Biomédicas

UNIVERSIDAD CATOLICA DEL NORTE

Coquimbo, Chile

Miguel Reyes

Full Professor

Facultad de Ciencias Médicas

UNIVERSIDAD DE SANTIAGO DE CHILE, FACULTAD DE CIENCIAS MÉDICAS, ESCUELA DE MEDICINA

Santiago, Chile

Bernardo Morales

Profesor titular

Biologia

Universidad de Santiago de Chile

Santiago, Chile

Carolina Parra

Academic

Mechanical Engineering

UNIVERSIDAD TECNICA FEDERICO SANTA MARIA

Valparaíso, Chile

Valeria del Campo

Académica Asociada

Física

UNIVERSIDAD TÉCNICA FEDERICO SANTA MARÍA

Valparaiso, Chile

Ignacio Vargas

Profesor Asociado

Departamento de Ingeniería Hidráulica y Ambiental

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

Magdalena Walczak

Associate Professor

Mechanical and Metallurgical Engineering

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE, ESCUELA DE INGENIERÍA

Santiago, Chile

Ricardo Henriquez

Professor

Physics

UNIVERSIDAD TECNICA FEDERICO SANTA MARIA

Valparaiso, Chile

Cristian Ramírez

Profesor Asociado

Chemical and Environmental Engineering Department

UNIVERSIDAD TECNICA FEDERICO SANTA MARIA

Valparaiso, Chile

Marcela Wilkens

Profesor Asociado

Biología

UNIVERSIDAD DE SANTIAGO DE CHILE

Santiago, Chile

Nelson Barrera

Associate Professor

Physiology

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

Santiago, Chile

Christian Wilson

Associate professor

Bioquimica y Biologia Molecular

Universidad de Chile

Santiago, Chile

Sheila Lascano

Profesor Auxiliar

Ingeniería Mecánica

UNIVERSIDAD TECNICA FEDERICO SANTA MARIA

Santiago de Chile, Chile

Jaime Retamal

Profesor Asociado

Medicina Intensiva

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

Santiago, Chile

Nathalie Casanova

profesor asociado

artes liberales

Universidad Adolfo Ibañez

Santiago, Chile

Bruna Benso

Profesora Asistente

Facultad de Medicina

Pontificia Universidad Católica de Chile

Santiago, Chile

Maria Godoy

Jefa de Proyectos Internacionales

Universidad Andrés Bello

Santiago, Chile

Pablo Conejeros

Profesor Adjunto

Universidad de Valparaiso

Valparaiso, Chile

Francisco Montero

Investigador Responsable, pryecto FOndecyt postdoctorado 3180683

Química

Universidad Austral de Chile

Valdivia, Chile

María Vera

Académico

Medicina Intensiva

Pontificia Universidad Catolica de Chile

Santiago, Chile

Juan Pablo Garcia Huidobro

Full Professor

Biology

Universidad de Santiago de Chile

Santiago, Chile

Mariana Rios

Investigador

Facultad de Ciencias Biológicas

pontificia Universidad Católica de Chile

Santiago, Chile

Juan Araya

Instructor

Análisis Instrumental

Universidad de Concepción

Concepción, Chile

Eduardo Troncoso

Técnico

Centro de Biotecnología

Universidad de Concepción

Concepción, Chile

Sebastián Aguayo

Assistant Professor

Dentistry

Pontificia Universidad Católica de Chile

Santiago, Chile

Andres Ramirez

Profesor Asosiado

Facultad de Ingenieria y Ciencia

Universidad de La Frontera

Temuco, Chile

María Vargas

Postdoctoral

Departamento de Química

Laboratorio de Microbiología Molecular y Biotecnología Ambiental

Valparaíso, Chile

Christina Schuh

Associate Professor

Centre for Regenerative Medicine

Universidad del Desarrollo

Santiago, Chile

PAOLA SOTO

Investigadora Laboratorio Fisiología Integrativa y Molecular

Facultad de Medicina

Universidad de Los Andes

Santiago, Chile

Sebastián Loyola

Académico Investigador

Ciencias de la Salud

Universidad Católica Silva Henriquez

Santiago, Chile

simon alvarez

Asistente de investigación

Facultad de Medicina

Universidad del Desarrollo

Santiago, Chile

Luis Caro

Encargado Ambiental

Instituto Antártico Chileno

PUNTA ARENAS, Chile

Nelson Patricio Barrera Rojas

Líneas de Investigación

Educación

Biochemistry, PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE. Chile, 1997

Biochemistry, PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE. Chile, 1999

Biological Sciences with major in Physiology, PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE. Chile, 2004

Experiencia Académica

Assistant Professor Full Time

Visiting Professor Other

Research Associate Other

Research Associate Other

Associate Professor Full Time

Experiencia Profesional

Assistant Professor Full Time

Associate Professor Full Time

Formación de Capital Humano

Premios y Distinciones

Outstanding Contribution Award

Isaac Newton Institute Award

Article (57)

Abstract (12)

BookSection (2)

Proyecto (18)

Aplicación de Espectrometría de Masas de Alta Resolución para potenciar estudios interdisciplinarios de proteómica, biología estructural y biomedicina=> desde péptidos hasta complejos supramoleculares intactos

Desarrollo de un metodo integrado de medicion de las propiedades biomecanicas de celulas vivas y biomateriales=> una nueva aproximacion para evaluar biocompatibilidad

CONTROL AND COORDINATION OF MICROVASCULAR VASOMOTOR TONE BY NITRIC OXIDE-DEPENDENT REGULATION OF CONNEXIN- AND PANNEXIN-FORMED GAP JUNCTION CHANNELS OR HEMICHANNELS

Determinación de la arquitectura molecular y funcional de los hemicanales de conexinas heteromericas Cx26/Cx30

High-Speed Analysis of Cross-Talk between Neurotransmitter-Gated Channels

Regulacion molecular de las dinamicas de apertura del canal formado por Panexina-1 en la celula endotelial=> La respuesta gatillada por CGRP

PROCESOS PRO-INFLAMATORIOS MODIFICAN LAS PROPIEDADES BIOMECÃ�NICAS CELULARES QUE REGULAN EL TRANSPORTE MUCOCILIAR EN EL EPITELIO RESPIRATORIO

ANALISIS ESTRUCTURAL DEL COMPLEJO MODIFICADOR DE CROMATINA LHC MEDIANTE ESPECTROMETRIA DE MASA Y MICROSCOPIA DE FUERZA ATOMICA.

Nano-devices for high precision measurements in biology and nano structured materials for biomedicine

Single molecule pharmacology of P2X receptors by atomic force microscopy

The Membrane Protein Structural Biology Millennium Nucleus

Role of detergent micelles on the stoichiometry of intact membrane proteins in the gas phase

Dynamic multiprotein complexes-insights from mass spectrometry

Review (4)