Man

Ricardo Mauricio Cabrera Paucar

Assitant Pofessor

UNIVERSIDAD DE CHILE

Santiago, Chile

Líneas de Investigación


Origin of Life, Structure and evolution of enzymes; metabolic fluxes in bacteria

Educación

  •  Structural Biology, Metabolism, UNIVERSIDAD DE CHILE. Chile, 2004

Experiencia Académica

  •   Profesor Asistente Full Time

    UNIVERSIDAD DE CHILE

    Ciencias

    Santiago, Chile

    2010 - A la fecha

Experiencia Profesional

  •   Assitant Professor Full Time

    Universidad de Chile

    Santiago, Chile

    2010 - A la fecha


 

Article (33)

Oxidation of chlortetracycline and its isomers by Botrytis aclada laccase in the absence of mediators: pH dependence and identification of transformation products by LC-MS

de Fatima, Nadia Gavilan; Barriga, Andres; Caceres, Juan Carlos; Pinto, Ernani; Cabrera, Ricardo

Article ISI
BIODEGRADATION  (2023)

Engineering an acetoacetyl-CoA reductase from Cupriavidus necator toward NADH preference under physiological conditions

Pijman, Yared O.; Cabrera, Ricardo

Article ISI
Scientific Reports  (2022)

An NADH preferring acetoacetyl-CoA reductase is engaged in poly-3-hydroxybutyrate accumulation in Escherichia coli

Olavarria, Karel; Carnet, Alexandre; van Renselaar, Joachim; Quakkelaar, Caspar; Cabrera, Ricardo; da Silva, Leonor Guedes; Smids, Aron L.; Andres Villalobos, Pablo; van Loosdrecht, Mark C. M.; Wahl, S. Aljoscha

Article ISI
JOURNAL OF BIOTECHNOLOGY  (2021)

Comparative characterization of the hemocyanin-derived phenol oxidase activity from spiders inhabiting different thermal habitats

Caceres, Juan Carlos; Barriga, Andres; Cabrera, Ricardo; Veloso, Claudio

Article ISI
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY B-BIOCHEMISTRY & MOLECULAR BIOLOGY  (2021)

Crystal structure of the 6-phosphogluconate dehydrogenase from Gluconobacter oxydans reveals tetrameric 6PGDHs as the crucial intermediate in the evolution of structure and cofactor preference in the 6PGHD family

Maturana, Pablo; Fuentealba, Matias; Roversi, Pietro; Cabrera, Ricardo

Article
Wellcome Open Research  (2021)

Deletion and Randomization of Structurally Variable Regions in B. subtilis Lipase A (BSLA) Alter Its Stability and Hydrolytic Performance Against Long Chain Fatty Acid Esters

Concha, Christopher; Cabrera, Ricardo; Dhoke, Gaurao V.

Article ISI SCOPUS
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES  (2020)

Functional characterisation and in silico modelling of MdPSY2 variants and MdPSY5 phytoene synthases from Malus domestica

Godoy, Francisca; Caceres, Juan Carlos; Cabrera, Ricardo

Article ISI
JOURNAL OF PLANT PHYSIOLOGY  (2020)

Fluorescence enzymatic assay for bacterial polyphosphate kinase 1 (PPK1) as a platform for screening antivirulence molecules

Lagos, Carlos F; Cabrera, Ricardo

Article ISI
INFECTION AND DRUG RESISTANCE  (2019)

Studying the phosphoryl transfer mechanism of the E. coli phosphofructokinase-2=> from X-ray structure to Quantum Mechanics/Molecular Mechanics simulations

Murillo-López, Juliana; Zinovjev, Kirill; Pereira, Humberto; Caniuguir, Andrés; Garratt, Richard; Babul, Jorge; Recabarren, Rodrigo; Alzate-Morales, Jans; Caballero, Julio; Tuñón, Iñaki; Cabrera, Ricardo

Article
CHEMICAL SCIENCE  (2019)

Surfaces based on amino acid functionalized polyelectrolyte films towards active surfaces for enzyme immobilization

VILLALOBOS, VALERIA; Queneau, Yves; Silva Danna, Caroline; Pavez, Jorge.; Cabrera, Ricardo; Tamayo, Laura; Urzua, Marcela D.

Article ISI SCOPUS
MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS  (2019)

Cold tolerance mechanisms of two arthropods from the Andean Range of Central Chile=> Agathemera crassa (Insecta=> Agathemeridae) and Euathlus condorito (Arachnida=> Theraphosidae)

Cubillos, Claudio; Cáceres, Juan Carlos; Villablanca, Cristopher; Villarreal, Pablo; Baeza, Marcelo; Cabrera, Ricardo; Graether, Steffen P; Veloso, Claudio

Article
Journal of Thermal Biology  (2018)

Inorganic Polyphosphate, Exopolyphosphatase, and Pho84-Like transporters may be Involved in copper resistance in Metallosphaera sedula DSM 5348T

Rivero, Matias; Torres-Paris, Constanza; Muñoz, Rodrigo; Cabrera, Ricardo; Navarro, C.A.; Jerez, Carlos

Article
Archaea  (2018)

Understanding the impact of the cofactor swapping of isocitrate dehydrogenase over the growth phenotype of Escherichia coli on acetate by using constraint-based modeling

Armingol, Erick; Tobar, Eduardo; Cabrera, Ricardo

Article
PLOS ONE  (2018)

Datasets for transcriptomics, q-proteomics and phenotype microarrays of polyphosphate metabolism mutants from Escherichia coli.

Varas, Macarena; Valdivieso, Camilo; Mauriaca, Cecilia; Ortíz-Severín, Javiera; Paradela, Alberto; Poblete-Castro, Ignacio; Cabrera, Ricardo; Chávez, Francisco P

Article
Data in brief  (2017)

Multi-level evaluation of Escherichia coli polyphosphate related mutants using global transcriptomic, proteomic and phenomic analyses

Varas, Macarena; Valdivieso, Camilo; Mauriaca, Cecilia; Ortíz-Severín, Javiera; Paradela, Alberto; Poblete-Castro, Ignacio; Cabrera, Ricardo; Chávez, Francisco P

Article
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS  (2017)

Determinants of Cofactor Specificity for the Glucose-6-Phosphate Dehydrogenase from Escherichia coli: Simulation, Kinetics and Evolutionary Studies

fuentealba, m; Munoz, R.; Maturana P.; Krapp, A; Cabrera, R

Article ISI SCOPUS
PLOS ONE  (2016)

Dictyostelium discoideum as a surrogate host-microbe model for antivirulence screening in Pseudomonas aeruginosa PAO1

Bravo-Toncio, C; Álvarez JA; Campos F; Ortíz-Severín J; Varas M; Cabrera R; Lagos CF; Chávez FP

Article
INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS  (2016)

Polyol specificity of recombinant Arabidopsis thaliana sorbitol dehydrogenase studied by enzyme kinetics and in silico modeling

Caceres J.C.; fuentealba, m; Munoz, R.; Stange, C.; Cabrera, R; Handford, M.

Article ISI SCOPUS
FRONTIERS IN PLANT SCIENCE  (2015)

Metabolic impact of an NADH-producing glucose-6-phosphate dehydrogenase in Escherichia coli

Olavarria, K; De Ingeniis, J; Zielinski, DC; fuentealba, m; Munoz, R.; McCloskey, D; Feist, AM; Cabrera, R

Article ISI SCOPUS
MICROBIOLOGY-SGM  (2014)

A Ribokinase Family Conserved Monovalent Cation Binding Site Enhances the MgATP-induced Inhibition in E . coli Phosphofructokinase-2

Baez, Mauricio; Cabrera, Ricardo; Pereira, Humberto M; Blanco, Alejandro; Villalobos, Pablo; Ramírez-Sarmiento, César A; Caniuguir, Andrés; Guixé, Victoria; Garratt, Richard C; Babul, Jorge

Article
BIOPHYSICAL JOURNAL  (2013)

Sorbitol dehydrogenase is a cytosolic protein required for sorbitol metabolism in Arabidopsis thaliana

Aguayo, MF; Ampuero, D.; Mandujano, P,; Parada R.; Munoz, R.; Gallart, M; Altabella, T; Cabrera, R; Stange, C.; Handford, M.

Article ISI SCOPUS
Plant Science  (2013)

Modeling the Interfacial Interactions between CrtS and CrtR from Xanthophyllomyces dendrorhous, a P450 System Involved in Astaxanthin Production

Alcaíno J.; fuentealba, m; Cabrera, R; Baeza, M.; Cifuentes, V

Article ISI SCOPUS
Journal of Agricultural and Food Chemistry  (2012)

The cofactor preference of glucose-6-phosphate dehydrogenase from Escherichia coli- modeling the physiological production of reduced cofactors

Olavarria, K; Valdes, D.; Cabrera, R

Article ISI SCOPUS
FEBS Journal  (2012)

The Crystal Complex of Phosphofructokinase-2 of Escherichia coli with Fructose-6-phosphate KINETIC AND STRUCTURAL ANALYSIS OF THE ALLOSTERIC ATP INHIBITION

Cabrera, R; Baez, M; Babul, J.

Article ISI SCOPUS
Journal of Biological Chemistry  (2011)

Ribokinase family evolution and the role of conserved residues at the active site of the PfkB subfamily representative, Pfk-2 from Escherichia coli

Cabrera, R; Babul, J.; Guixe, V

Article ISI SCOPUS
Archives of Biochemistry and Biophysics  (2010)

Crystallographic Structure of Phosphofructokinase-2 from Escherichia coli in Complex with Two ATP Molecules. Implications for Substrate Inhibition

Cabrera, R; Ambrosio, ALB; Garratt, RC; Guixe, V; Babul, J.

Article ISI SCOPUS
JOURNAL OF MOLECULAR BIOLOGY  (2008)

Unfolding pathway of the dimeric and tetrameric forms of phosphofructokinase-2 from Escherichia coli

Baez, M; Cabrera, R; Guixe, V; Babul, J.

Article ISI SCOPUS
BIOCHEMISTRY  (2007)

Crystallization and preliminary crystallographic analysis of the tetrameric form of phosphofructokinase-2 from Escherichia coli, a member of the ribokinase family

Cabrera, R; Caniuguir, A; Ambrosio, ALB; Guixe, V; Garratt, RC; Babul, J.

Article ISI SCOPUS
ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY AND CRYSTALLIZATION COMMUNICATIONS  (2006)

Evidence for a catalytic Mg2+ ion and effect of phosphate on the activity of Escherichia coli phosphofructokinase-2: Regulatory properties of a ribokinase family member

Parducci, RE; Cabrera, R; Baez, M; Guixe, V

Article ISI SCOPUS
BIOCHEMISTRY  (2006)

Role of Cys-295 on subunit interactions and allosteric regulation of phosphofructokinase-2 from Escherichia coli

Caniuguir, A; Cabrera, R; Baez, M; Vásquez CC; Babul, J.; Guixe, V

Article ISI SCOPUS
FEBS LETTERS  (2005)

Undergraduate teaching of evolution in chile: more than natural selection

Ahumada P.; astorga, g; Bull-Herenu, K; Cabrera, R; caputo, L; Carmona, C.; Cortes N.; Cortez, S; Dorador, C.; Fredes, F; et al.

Article ISI SCIELO SCOPUS
Revista chilena de historia natural  (2005)

Domain motions and quaternary packing of phosphofructokinase-2 from Escherichia coli studied by small angle X-ray scattering and homology modeling

Cabrera, R; Fischer, H; Trapani, S; Craievich, AF; Garratt, RC; Guixe, V; Babul, J.

Article ISI SCOPUS
JOURNAL OF BIOLOGICAL CHEMISTRY  (2003)

Ligand-dependent structural changes and limited proteolysis of Escherichia coli phosphofructokinase-2

Cabrera, R; Guixe, V; Alfaro, J; Babul, J.

Article ISI SCOPUS
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS  (2002)

Abstract (6)

Atomic Force Microscopy Imaging Reveals Structural and Mechanical Properties of Dissociated Hemocyanins by Temperature

Navarrete C.; Villar, J; Aguilar, Y; Cabrera, R; Barrera, NP

Abstract ISI
BIOPHYSICAL JOURNAL  (2014)

Role of the conserved N187 residue of E-coli Pfk-2 in catalysis and allosteric regulation

Guixe, V; Caniuguir, A; Cabrera, R

Abstract ISI
FEBS JOURNAL  (2007)

Thermal unfolding of the dimeric wild-type and a monomeric mutant phosphofructokinase-2 from E-coli

Babul, J.; Baez, M; Cabrera, R

Abstract ISI
FEBS JOURNAL  (2007)

Dimer-tetramer transition and the allosteric regulation of phosphofructokinase-2 from E-coli

Baez, M; Caniuguir, A; Cabrera, R; Babul, J.

Abstract ISI
FEBS JOURNAL  (2005)

On the catalytic role of conserved active site residues D256 and E190 of Escherichia coli Phosphofructokinase-2, a member of the ribokinase family

Cabrera, R; Parducci, R; Guixe, V

Abstract ISI
FEBS JOURNAL  (2005)

Allosteric control of the oligomerization of phosphofructokinase-2 from E-coli.

Guixe, V; Cabrera, R; Baez, M; Babul, J.

Abstract ISI
FASEB JOURNAL  (2002)

Proyecto (12)

Prebiotic oxidation of Glyceraldehyde(3P) catalyzed by W/Mo: the evolutionary origin of an energy-conserving metabolic pathway



Proyecto
 (2022)

A novel deletion/randomization protein engineering strategy and its validation through improvement of B. subtilis lipase A for applied biocatalysis

FONDECYT (1170219)

Proyecto
2017-2019
Coinvestigador(a)

Desarrollo, producción y caracterización de anticuerpo recombinante humano contra MIC-A con potencial terapéutico para el tratamiento de cáncer gástrico

FONDEF (ID16I10027)

Proyecto
2016-2017
Investigador(a)

Growth bioenergetics and electricity generation at high reducing power in Escherichia coli=> Testing the NADH-NADPH dichotomy

UNIVERSIDAD DE CHILE - FAC. CIENCIAS (Fondos PAIFAC 2016 - Ricardo Cabrera)

Proyecto
2016-2016
Inv. Principal

Rewiring supply-demand of reduced power in E. coli=> consequences in growth and bioelectricity

UNIVERSIDAD DE CHILE - VID (VID Ricardo Cabrera)

Proyecto
2016-2016
Inv. Principal

Ingeniería metabólica en plantas, levaduras y bacterias

UNIVERSIDAD DE CHILE (U-REDES)

Proyecto
2013-2013
Inv. Principal

EQUIPO DE CRISTALIZACION HIGH-TROUGHPUT DE PROTEINAS

FONDEQUIP (EQM120208)

Proyecto
2012-2013
Investigador(a)

REDUCING POWER PRODUCTION IN E. COLI=> A ROLE FOR SPECIFICITY TO NICOTINAMIDE DINUCLEOTIDES OF CENTRAL DEHYDROGENASES

FONDECYT (1121170)

Proyecto
2012-2016
Inv. Responsable

INTEGRACION DE LA BIOLOGIA ESTRUCTURAL AL DESARROLLO DE LA BIONANOTECNOLOGIA

PIA (ACT1107)

Proyecto
2011-2015
Investigador(a)

A COMPREHENSIVE MODEL FOR THE MECHANISM OF ALLOSTERIC REGULATION OF E. COLI PHOSPHOFRUCTOKINASE-2. INTEGRATION OF KINETIC, STRUCTURAL, DYNAMIC AND MECHANIC ASPECTS.

FONDECYT (1090336)

Proyecto
2009-2013
Coinvestigador(a)

METABOLIC EFFECTS OF AN ENGINEERED GLUCOSE-6-P DEHYDROGENASE WITH REVERSED NADP-NAD COFACTOR SPECIFICITY

FONDECYT (11080290)

Proyecto
2008-2011
Inv. Responsable

Distribución de flujos y balance de cofactores en el metabolismo del acetato de E. coli

UNIVERSIDAD DE CHILE (DI I2 06/02-2)

Proyecto
2006-2008
Inv. Responsable

1
Marcelo Baeza

Profesor Titular

Ciencias Ecologicas

Universidad de Chile

Santiago, Chile

1
Víctor Cifuentes

Prof. Titular

Departamento de Ciencias Ecológicas

FACULTAD DE CIENCIAS, UNIVERSIDAD DE CHILE.

Santiago, Chile

1
Marcela Urzúa

Associate Professor

Chemistry

UNIVERSIDAD DE CHILE

Santiago, Chile

1
Sergio Álvarez

Profesor Asistente

Bioquímica y Biología Molecular

UNIVERSIDAD DE CHILE. FACULTAD DE CIENCIAS QUÍMICAS Y FARMACÉUTICAS

Santiago, Chile

1
Francisco Chávez

Profesor Asistente

Departamento de Biología

Universidad de Chile

Santiago, Chile

2
Claudia Stange

Titular Professor

Department of Biology

UNIVERSIDAD DE CHILE

Santiago, Chile

11
Jorge Babul

UNIVERSIDAD DE CHILE

Santiago, Chile

11
Victoria Guixé

Titular Profesor

Biology

UNIVERSIDAD DE CHILE

Santiago, Chile

32
Ricardo Cabrera

Assitant Pofessor

Biology

UNIVERSIDAD DE CHILE

Santiago, Chile

2
Michael Handford

Full Professor

UNIVERSIDAD DE CHILE, FACULTAD DE CIENCIAS, DEPARTAMENTO DE BIOLOGÍA

Santiago, Chile

1
JORGE PAVEZ

Professor

Materials Chemistry

UNIVERSIDAD DE SANTIAGO DE CHILE

Santiago, Chile

1
Pablo Henny

Profesor Asociado

Anatomía Normal

Pontificia Universidad Católica de Chile

Santiago, Chile

1
Pablo Razeto

Researcher

CENTRO NACIONAL DEL MEDIO AMBIENTE

Santiago, Chile

1
Nelson Velásquez

Auxiliary Professor

Biology and Chemistry

Catholic University of the Maule

Talca, Chile

1
Jennifer Alcaíno

Profesor Asociado

Ciencias Ecológicas

UNIVERSIDAD DE CHILE - FACULTAD DE CIENCIAS

Santiago, Chile

7
Mauricio Baez

Assistant Professor

Bioquímica y Biología Molecular

UNIVERSIDAD DE CHILE

Santiago, Chile

1
Nelson Barrera

Associate Professor

Physiology

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

Santiago, Chile

1
Claudia Bernal

Academica

Departamento de Química

Universidad de La Serena

La Serena, Chile

1
luciano caputo

Assistant professor

Institute of Marine and Limnology Science

UNIVERSIDAD AUSTRAL DE CHILE

Valdivia, Chile

1
Mauricio Fuentealba

Profesor Adjunto

Pontificia Universidad Católica de Valparaíso

Valparaíso, Chile

1
Cristina Dorador

PROFESSOR

Biotechnology

UNIVERSIDAD DE ANTOFAGASTA

ANTOFAGASTA, Chile

1
Alexander Vargas

Profesor Asociado

Biología

Universidad de Chile

Santiago, Chile

1
Tomás Ossandón

Associate Professor

Medical School, Department of Psychiatry

Pontificia Universidad Católica de Chile

Santiago, Chile

1
Carlos Lagos

Profesor Asociado

FACULTAD DE MEDICINA Y CIENCIA

UNIVERSIDAD SAN SEBASTIÁN

SANTIAGO, Chile

1
David Rubilar

Curator

Museo Nacional de Historia Natural

Santiago, Chile

1
Pablo Maturana

Estudiante de Doctorado

Departamento de Biología

Universidad de Chile

Santiago, Chile

1
Ronny Martinez

Profesor Asociado

Ingenieria en Alimentos

UNIVERSIDAD DE LA SERENA

La Serena, Chile

1
Laura Tamayo

PROFESOR ASISTENTE

DEPARTAMENTO DE QUÍMICA

UNIVERSIDAD DE CHILE

SANTIAGO, Chile

1
Jaime Martinez

Investigador

Instituto de Investigaciones Agropecuarias, INIA - La Cruz

La Cruz, Chile

1
Marcelo Baeza

1
Maria Godoy

Jefa de Proyectos Internacionales

Universidad Andrés Bello

Santiago, Chile

1
CHRISTOPHER CONCHA

Investigador

Acuicultura

Universidad Católica del Norte

Coquimbo, Chile

1
Pablo Villalobos

Investigador postdoctoral

Biología

Universidad de Chile

Santiago, Chile

1
Valeria Villalobos

Profesor asistente

Universidad Autónoma de Chile

Santiago, Chile

1
Caroline Silva

Profesor Asistente

Instituto de Materiales y Procesos Termomecánicos

Universidad Austral de Chile

Valdivia, Chile

1
Carlos Salas

Gerente de Innovación y Desarrollo

Vivero del Maipo Ltda.

San José de Maipo, Chile