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Jorge Babul Cattan

UNIVERSIDAD DE CHILE

Santiago, Chile

Protein structure, folding and stability; Structure and allosteric regulation of phosphofructokinase-2 from E. coli; Structural and kinetic characterization of enzymes of the ribokinase superfamily; Biophysics of Protein Folding; Single-molecule studies of the Folding of the Knotted Proteins.; Evolutives studies of the ribokinase superfamily; Folding and allosteric regulation of Pfk-2 from E. coli


Characterization of hydroxymethylpyrimidine phosphate kinase from mesophilic and thermophilic bacteria and structural insights into their differential thermal stability Cea, Pablo A.; Araya, Gissela; Vallejos, Gabriel; Recabarren, Rodrigo; Alzate-Morales, Jans; Babul, Jorge; Guixe, Victoria; Castro-Fernandez, Victor Article ISI ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS (2020)
Intrinsically Disordered Regions of the DNA-Binding Domain of Human FoxP1 Facilitate Domain Swapping Medina, E., Villalobos, P., Hamilton, G.L., Komives, E.A., Sanabria, H., Ramírez-Sarmiento, C.A., Babul, JelExequielMedina1PabloVillalobos1George L.Hamilton2Elizabeth A.Komives3HugoSanabria2César A.Ramírez-Sarmiento45JorgeBabul1 Article Jornal o Molecular Biology (2020)
Studying the phosphoryl transfer mechanism of the phosphofructokinase-2=> from X-ray structure to quantum mechanics/molecular mechanics simulations. Murillo-López, Juliana; Zinovjev, Kirill; Pereira, Humberto; Caniuguir, Andres; Garratt, Richard; Babul, Jorge; Recabarren, Rodrigo; Alzate-Morales, Jans; Caballero, Julio; Tuñón, Iñaki; Cabrera, Ricardo Article Chemical science (2019)
The protonation state of an evolutionarily conserved histidine modulates domainswapping stability of FoxP1 Medina, Exequiel; Villalobos, Pablo; Conuecar, Ricardo; Ramirez-Sarmiento, Cesar A.; Babul, Jorge Article ISI SCOPUS Scientific Reports (2019)
New visible and selective DNA staining method in gels with tetrazolium salts. Paredes, Aaron J; Naranjo-Palma, Tatiana; Alfaro-Valdés, Hilda M; Barriga, Andrés; Babul, Jorge; Wilson, Christian A M Article Analytical biochemistry (2017)
Unusual dimerization of a BcCsp mutant leads to reduced conformational dynamics. Carvajal, Alonso I; Vallejos, Gabriel; Komives, Elizabeth A; Castro-Fernández, Víctor; Leonardo, Diego A; Garratt, Richard C; Ramírez-Sarmiento, César A; Babul, Jorge Article The FEBS journal (2017)
Three-Dimensional Domain Swapping Changes the Folding Mechanism of the Forkhead Domain of FoxP1 medina, e; Cordova, C; Villalobos, P.; Reyes, J; Komives E.A.; Ramírez-Sarmiento C.A.; Babul, J. Article ISI SCOPUS Biophysical Journal (2016)
Role of monovalent and divalent metal cations in human ribokinase catalysis and regulation Quiroga-Roger, D; Babul, J.; Guixe, V Article ISI SCOPUS BioMetals (2015)
The Folding Unit of Phosphofructokinase-2 as Defined by the Biophysical Properties of a Monomeric Mutant Ramirez-Sarmiento, CA; Baez, M; Zamora, RA; Balasubramaniam, D; Babul, J.; Komives, EA; Guixe, V Article ISI SCOPUS Biophysical Journal (2015)
A Ribokinase Family Conserved Monovalent Cation Binding Site Enhances the MgATP-induced Inhibition in E. coli Phosphofructokinase-2 Baez, M; Cabrera, R; Pereira, HM; Blanco A.; Villalobos, P.; Ramirez-Sarmiento, CA; Caniuguir, A; Guixe, V; Garratt, RC; Babul, J. Article ISI SCOPUS BIOPHYSICAL JOURNAL (2013)
Observation of Solvent Penetration during Cold Denaturation of E. coli Phosphofructokinase-2 Ramirez-Sarmiento, CA; Baez, M; Wilson, CAM; Babul, J.; Komives, EA; Guixe, V Article ISI SCOPUS BIOPHYSICAL JOURNAL (2013)
Expanded Monomeric Intermediate upon Cold and Heat Unfolding of Phosphofructokinase-2 from Escherichia coli Baez, M; Wilson, C.A.M.; Ramirez-Sarmiento, C.A.; Guixe, V; Babul, J. Article ISI SCOPUS BIOPHYSICAL JOURNAL (2012)
Divalent metal cation requirements of phosphofructokinase-2 from E. coli. Evidence for a high affinity binding site for Mn2+ Rivas-Pardo, JA; Caniuguir, A; Wilson, CAM; Babul, J.; Guixe, V Article ISI SCOPUS Archives of Biochemistry and Biophysics (2011)
Folding kinetic pathway of phosphofructokinase-2 from Escherichia coli: A homodimeric enzyme with a complex domain organization Baez, M; Wilson, CAM; Babul, J. Article ISI SCOPUS FEBS Letters (2011)
The Crystal Complex of Phosphofructokinase-2 of Escherichia coli with Fructose-6-phosphate KINETIC AND STRUCTURAL ANALYSIS OF THE ALLOSTERIC ATP INHIBITION Cabrera, R; Baez, M; Caniuguir A.S.; Babul, J.; Pereira H.M.; Garratt R.C. Article ISI SCOPUS Journal of Biological Chemistry (2011)
Ribokinase family evolution and the role of conserved residues at the active site of the PfkB subfamily representative, Pfk-2 from Escherichia coli Cabrera, R; Babul, J.; Guixe, V Article ISI SCOPUS Archives of Biochemistry and Biophysics (2010)
Reversible unfolding of dimeric phosphofructokinase-2 from Escherichia coli reveals a dominant role of inter-subunit contacts for stability Baez, M; Babul, J. Article ISI SCOPUS FEBS LETTERS (2009)
Crystallographic Structure of Phosphofructokinase-2 from Escherichia coli in Complex with Two ATP Molecules. Implications for Substrate Inhibition Cabrera, R; Ambrosio, ALB; Garratt, RC; Guixe, V; Babul, J. Article ISI SCOPUS JOURNAL OF MOLECULAR BIOLOGY (2008)
Uncoupling the MgATP-induced inhibition and aggregation of Escherichia coli phosphofructokinase-2 by C-terminal mutations Baez, M; Merino F.; astorga, g; Babul, J. Article ISI SCOPUS FEBS LETTERS (2008)
Unfolding pathway of the dimeric and tetrameric forms of phosphofructokinase-2 from Escherichia coli Baez, M; Cabrera, R; Guixe, V; Babul, J. Article ISI SCOPUS BIOCHEMISTRY (2007)
Crystallization and preliminary crystallographic analysis of the tetrameric form of phosphofructokinase-2 from Escherichia coli, a member of the ribokinase family Cabrera, R; Caniuguir, A; Ambrosio, ALB; Guixe, V; Garratt, RC; Babul, J. Article ISI SCOPUS ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY AND CRYSTALLIZATION COMMUNICATIONS (2006)
Role of Cys-295 on subunit interactions and allosteric regulation of phosphofructokinase-2 from Escherichia coli Caniuguir, A; Cabrera, R; Baez, M; Vásquez CC; Babul, J.; Guixe, V Article ISI SCOPUS FEBS LETTERS (2005)
Domain motions and quaternary packing of phosphofructokinase-2 from Escherichia coli studied by small angle X-ray scattering and homology modeling Cabrera, R; Fischer, H; Trapani, S; Craievich, AF; Garratt, RC; Guixe, V; Babul, J. Article ISI SCOPUS JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
Structural and functional roles of Cys-238 and Cys-295 in Escherichia coli phosphofructokinase-2 Baez, M; Rodriguez, PH; Babul, J.; Guixe, V Article ISI SCOPUS BIOCHEMICAL JOURNAL (2003)
Ligand-dependent structural changes and limited proteolysis of Escherichia coli phosphofructokinase-2 Cabrera, R; Guixe, V; Alfaro, J; Rodriguez, PH; Babul, J. Article ISI SCOPUS ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS (2002)


Domain swapping of the DNA-binding domain of human FoxP1 is facilitated by its low folding stability medina, e; Valenzuela SL; Cordova, C; Ramirez-Sarmiento, CA; Babul, J. Abstract ISI PROTEIN SCIENCE (2015)
Allosteric communication between subunits of the dimeric phosphofructokinase-2 of E. coli analyzed by hybrid enzymes and molecular simulations Villalobos, P.; Soto, F.; Baez, M; Babul, J. Abstract ISI FEBS JOURNAL (2012)
Dimer-tetramer conversion induced by MgATP is coupled with the binding of K plus to phosphofructokinase-2 of E. coli: implications for the allosteric regulation by the nucleotide Babul, J.; Vallejos G.; Peña D.; Baez, M Abstract ISI PROTEIN SCIENCE (2012)
Direct Observation Of Solvent Penetration During Cold Denaturation Of Pfk-2 By Amide Hydrogen/Deuterium (H/H-2) Exchange Mass Spectrometry Ramirez-Sarmiento, C; Baez, M; Babul, J.; Komives, E; Guixe, V Abstract ISI PROTEIN SCIENCE (2012)
Structural and kinetic basis for the enhanced allosteric ATP inhibition induced by monovalent cations in phosphofructokinase-2 from E. coli Baez, M; Caniuguir, A; Pereira, HM; Garratt, RC; Babul, J. Abstract ISI FEBS JOURNAL (2011)
Thermal unfolding of the dimeric wild-type and a monomeric mutant phosphofructokinase-2 from E-coli Babul, J.; Baez, M; Cabrera, R Abstract ISI FEBS JOURNAL (2007)
Dimer-tetramer transition and the allosteric regulation of phosphofructokinase-2 from E-coli Baez, M; Caniuguir, A; Cabrera, R; Babul, J. Abstract ISI FEBS JOURNAL (2005)
Reversible unfolding of dimeric phosphofructokinase-2 from E. coli Babul, J.; Baez, M; Guixe, V Abstract ISI FASEB JOURNAL (2004)
Allosteric control of the oligomerization of phosphofructokinase-2 from E-coli. Guixe, V; Cabrera, R; Baez, M; Babul, J. Abstract ISI FASEB JOURNAL (2002)


Biophysical and evolutionary assessment of the emergence of domain swapping within the Fox family of transcription factors FONDECYT (1170701) Proyecto 2017-2021 Inv. Responsable
FOLDING OF PROTEINS ASSISTED BY DNA BINDING=> ROLE OF ELECTROSTATIC INTERACTIONS IN THE DOMAIN SWAPPING MECHANISM OF THE FOXP AND CSP FAMILIES FONDECYT (1130510) Proyecto 2013-2017 Inv. Responsable
EVOLUTION OF RIBOKINASE SUPERFAMILY ENZYMES=> STRUCTURE-FUNCTION RELATIONSHIPS THAT DETERMINE SUBSTRATE SPECIFICITY, METAL ASSISTED MECHANISM AND PROTEIN STABILITY. FONDECYT (1110137) Proyecto 2011-2015 Coinvestigador(a)
A COMPREHENSIVE MODEL FOR THE MECHANISM OF ALLOSTERIC REGULATION OF E. COLI PHOSPHOFRUCTOKINASE-2. INTEGRATION OF KINETIC, STRUCTURAL, DYNAMIC AND MECHANIC ASPECTS. FONDECYT (1090336) Proyecto 2009-2013 Inv. Responsable
FILOGENIA, MECANISMO CATALITICO Y ESPECIFICIDAD DE SUSTRATO EN ENZIMAS DE LA SUPERFAMILIA RIBOQUINASA. IMPLICACIONES PARA LA EVOLUCION DE LA SUPERFAMILIA. FONDECYT (1070111) Proyecto 2007-2011 Coinvestigador(a)
FORMACION E INTERCONVERSION DE ESTRUCTURAS CUATERNARIAS DE ENZIMAS=> IMPORTANCIA DE LAS INTERFACES DE Pfk-2 DE E. COLI PARA LA ESTABILIDAD, LA ACTIVIDAD CATALITICA Y LA REGULACION ALOSTERICA. FONDECYT (1050818) Proyecto 2005-2009 Inv. Responsable
ANALISIS ESTRUCTURAL Y FUNCIONAL DE LOS SITIOS DE UNION DE LIGANDOS Y CONTROL ALOSTERICO DE LA OLIGOMERIZACION DE FOSFOFRUCTOQUINASA-2 DE E.COLI. FONDECYT (1040892) Proyecto 2004-2007 Coinvestigador(a)
ASOCIACION DE SUBUNIDADES EN ENZIMAS OLIGOMERICAS. REGULACION ALOSTERICA DE FOSFOFRUCTOQUINASA-2 DE E. COLI FONDECYT (1010645) Proyecto 2001-2005 Inv. Responsable
BASES ESTRUCTURALES DE LA REGULACION DE LA ACTIVIDAD DE LA FOSFOFRUCTOQUINASA-2 DE ESCHERICHIA COLI FONDECYT (1981091) Proyecto 1998-2001 Inv. Responsable
MUTANTES DE ESCHERICHIA COLI CON FOSFOFRUCTOQUINASAS QUE DIFIEREN EN SUS PROPIEDADES REGULADAS. ESTUDIOS METABOLICOS Y ESTRUCTURALES FONDECYT (1950297) Proyecto 1995-1998 Inv. Responsable
REGULACION IN VIVO DE LA GLICOLISIS Y GLUCONEOGENESIS EN CEPAS SILVESTRE Y MUTANTES DE ESCHERICHIA COLI FONDECYT (1921136) Proyecto 1992-1995 Inv. Responsable
USO DE MUTANTES DE E. COLI PARA CONOCER LAS RELACIONES ENTRE EL FLUJO METABOLICO IN VIVO Y LAS PROPIEDADES IN VITRO DE LA FOSFOFRUCTOQUINASA Y LA FRUCTOSA-BISFOSFATASA. FONDECYT (1891120) Proyecto 1989-1992 Inv. Responsable
SIGNIFICADO FISIOLOGICO DE LOS MECANISMOS DE REGULACION DE LAS ACTIVIDADES DE FOSFOFRUCTOQUINASA Y FRUCTOSA BISFOSFATASA. FONDECYT (1870482) Proyecto 1987-1988 Inv. Responsable
MUTANTES BACTERIANAS EN EL ESTUDIO DE LOS MECANISMOS REGULATORIOS DE FOSFOFRUCTOQUINASA U FRUCTOSA BISFOFATASA. FONDECYT (1841134) Proyecto 1984-1985 Inv. Responsable
PAPEL FISIOLOGICO DE LAS ISOENZIMAS. FONDECYT (1820255) Proyecto 1982-1983 Coinvestigador(a)

Jorge Babul

UNIVERSIDAD DE CHILE

Santiago, Chile

Victoria Guixé

Titular Profesor

Biology

UNIVERSIDAD DE CHILE

Santiago, Chile

Mauricio Baez

Assistant Professor

Bioquímica y Biología Molecular

UNIVERSIDAD DE CHILE

Santiago, Chile

Ricardo Cabrera

Assitant Pofessor

Biology

UNIVERSIDAD DE CHILE

Santiago, Chile

CESAR RAMIREZ

Assistant Professor

Institute for Biological and Medical Engineering

Pontificia Universidad Catolica de Chile

Santiago, Chile

Christian Wilson

Associate professor

Bioquimica y Biologia Molecular

Universidad de Chile

Santiago, Chile

Exequiel Medina

Researcher

BIología

Universidad de Chile

Santiago, Chile

Jaime Rivas

Assistant Professor

Facultad de Ciencias

Universidad Mayor

Santiago, Chile

Diego Quiroga

Investigation assistant at Biochemistry Lab (Chem and Pharm Sciences Fac, Dr. Christian AM Wilson)

Universidad de Chile

Santiago, Chile

Javiera Reyes

Alumno Doctorado

Ingeniería

Pontificia Universidad Católica de Chile

Santiago, Chile

Jans Alzate

Associate Professor

Departamento de Bioinformática

UNIVERSIDAD DE TALCA

Talca, Chile

Gabriel Vallejos

Investigador postdoctoral

Departamento de Biología

Universidad de Chile

Santiago, Chile

Ricardo Zamora

Researcher Assistant

Universidad de Talca

Talca, Chile

Víctor Castro

Profesor Asistente

Departamento de Biología

UNIVERSIDAD DE CHILE

Ñuñoa, Chile

Jorge Babul Cattan

Líneas de Investigación

Article (25)

Abstract (9)

Proyecto (15)

Biophysical and evolutionary assessment of the emergence of domain swapping within the Fox family of transcription factors

FOLDING OF PROTEINS ASSISTED BY DNA BINDING=> ROLE OF ELECTROSTATIC INTERACTIONS IN THE DOMAIN SWAPPING MECHANISM OF THE FOXP AND CSP FAMILIES

EVOLUTION OF RIBOKINASE SUPERFAMILY ENZYMES=> STRUCTURE-FUNCTION RELATIONSHIPS THAT DETERMINE SUBSTRATE SPECIFICITY, METAL ASSISTED MECHANISM AND PROTEIN STABILITY.

A COMPREHENSIVE MODEL FOR THE MECHANISM OF ALLOSTERIC REGULATION OF E. COLI PHOSPHOFRUCTOKINASE-2. INTEGRATION OF KINETIC, STRUCTURAL, DYNAMIC AND MECHANIC ASPECTS.

FILOGENIA, MECANISMO CATALITICO Y ESPECIFICIDAD DE SUSTRATO EN ENZIMAS DE LA SUPERFAMILIA RIBOQUINASA. IMPLICACIONES PARA LA EVOLUCION DE LA SUPERFAMILIA.

FORMACION E INTERCONVERSION DE ESTRUCTURAS CUATERNARIAS DE ENZIMAS=> IMPORTANCIA DE LAS INTERFACES DE Pfk-2 DE E. COLI PARA LA ESTABILIDAD, LA ACTIVIDAD CATALITICA Y LA REGULACION ALOSTERICA.

ANALISIS ESTRUCTURAL Y FUNCIONAL DE LOS SITIOS DE UNION DE LIGANDOS Y CONTROL ALOSTERICO DE LA OLIGOMERIZACION DE FOSFOFRUCTOQUINASA-2 DE E.COLI.

ASOCIACION DE SUBUNIDADES EN ENZIMAS OLIGOMERICAS. REGULACION ALOSTERICA DE FOSFOFRUCTOQUINASA-2 DE E. COLI

BASES ESTRUCTURALES DE LA REGULACION DE LA ACTIVIDAD DE LA FOSFOFRUCTOQUINASA-2 DE ESCHERICHIA COLI

MUTANTES DE ESCHERICHIA COLI CON FOSFOFRUCTOQUINASAS QUE DIFIEREN EN SUS PROPIEDADES REGULADAS. ESTUDIOS METABOLICOS Y ESTRUCTURALES

REGULACION IN VIVO DE LA GLICOLISIS Y GLUCONEOGENESIS EN CEPAS SILVESTRE Y MUTANTES DE ESCHERICHIA COLI

USO DE MUTANTES DE E. COLI PARA CONOCER LAS RELACIONES ENTRE EL FLUJO METABOLICO IN VIVO Y LAS PROPIEDADES IN VITRO DE LA FOSFOFRUCTOQUINASA Y LA FRUCTOSA-BISFOSFATASA.

SIGNIFICADO FISIOLOGICO DE LOS MECANISMOS DE REGULACION DE LAS ACTIVIDADES DE FOSFOFRUCTOQUINASA Y FRUCTOSA BISFOSFATASA.

MUTANTES BACTERIANAS EN EL ESTUDIO DE LOS MECANISMOS REGULATORIOS DE FOSFOFRUCTOQUINASA U FRUCTOSA BISFOFATASA.

PAPEL FISIOLOGICO DE LAS ISOENZIMAS.