Man

Jorge Babul Cattan

UNIVERSIDAD DE CHILE

Santiago, Chile

Líneas de Investigación


Protein structure, folding and stability; Structure and allosteric regulation of phosphofructokinase-2 from E. coli; Structural and kinetic characterization of enzymes of the ribokinase superfamily; Biophysics of Protein Folding; Single-molecule studies of the Folding of the Knotted Proteins.; Evolutives studies of the ribokinase superfamily; Folding and allosteric regulation of Pfk-2 from E. coli


 

Article (25)

Characterization of hydroxymethylpyrimidine phosphate kinase from mesophilic and thermophilic bacteria and structural insights into their differential thermal stability
Intrinsically Disordered Regions of the DNA-Binding Domain of Human FoxP1 Facilitate Domain Swapping
Studying the phosphoryl transfer mechanism of the phosphofructokinase-2=> from X-ray structure to quantum mechanics/molecular mechanics simulations.
The protonation state of an evolutionarily conserved histidine modulates domainswapping stability of FoxP1
New visible and selective DNA staining method in gels with tetrazolium salts.
Unusual dimerization of a BcCsp mutant leads to reduced conformational dynamics.
Three-Dimensional Domain Swapping Changes the Folding Mechanism of the Forkhead Domain of FoxP1
Role of monovalent and divalent metal cations in human ribokinase catalysis and regulation
The Folding Unit of Phosphofructokinase-2 as Defined by the Biophysical Properties of a Monomeric Mutant
A Ribokinase Family Conserved Monovalent Cation Binding Site Enhances the MgATP-induced Inhibition in E. coli Phosphofructokinase-2
Observation of Solvent Penetration during Cold Denaturation of E. coli Phosphofructokinase-2
Expanded Monomeric Intermediate upon Cold and Heat Unfolding of Phosphofructokinase-2 from Escherichia coli
Divalent metal cation requirements of phosphofructokinase-2 from E. coli. Evidence for a high affinity binding site for Mn2+
Folding kinetic pathway of phosphofructokinase-2 from Escherichia coli: A homodimeric enzyme with a complex domain organization
The Crystal Complex of Phosphofructokinase-2 of Escherichia coli with Fructose-6-phosphate KINETIC AND STRUCTURAL ANALYSIS OF THE ALLOSTERIC ATP INHIBITION
Ribokinase family evolution and the role of conserved residues at the active site of the PfkB subfamily representative, Pfk-2 from Escherichia coli
Reversible unfolding of dimeric phosphofructokinase-2 from Escherichia coli reveals a dominant role of inter-subunit contacts for stability
Crystallographic Structure of Phosphofructokinase-2 from Escherichia coli in Complex with Two ATP Molecules. Implications for Substrate Inhibition
Uncoupling the MgATP-induced inhibition and aggregation of Escherichia coli phosphofructokinase-2 by C-terminal mutations
Unfolding pathway of the dimeric and tetrameric forms of phosphofructokinase-2 from Escherichia coli
Crystallization and preliminary crystallographic analysis of the tetrameric form of phosphofructokinase-2 from Escherichia coli, a member of the ribokinase family
Role of Cys-295 on subunit interactions and allosteric regulation of phosphofructokinase-2 from Escherichia coli
Domain motions and quaternary packing of phosphofructokinase-2 from Escherichia coli studied by small angle X-ray scattering and homology modeling
Structural and functional roles of Cys-238 and Cys-295 in Escherichia coli phosphofructokinase-2
Ligand-dependent structural changes and limited proteolysis of Escherichia coli phosphofructokinase-2

Abstract (9)

Domain swapping of the DNA-binding domain of human FoxP1 is facilitated by its low folding stability
Allosteric communication between subunits of the dimeric phosphofructokinase-2 of E. coli analyzed by hybrid enzymes and molecular simulations
Dimer-tetramer conversion induced by MgATP is coupled with the binding of K plus to phosphofructokinase-2 of E. coli: implications for the allosteric regulation by the nucleotide
Direct Observation Of Solvent Penetration During Cold Denaturation Of Pfk-2 By Amide Hydrogen/Deuterium (H/H-2) Exchange Mass Spectrometry
Structural and kinetic basis for the enhanced allosteric ATP inhibition induced by monovalent cations in phosphofructokinase-2 from E. coli
Thermal unfolding of the dimeric wild-type and a monomeric mutant phosphofructokinase-2 from E-coli
Dimer-tetramer transition and the allosteric regulation of phosphofructokinase-2 from E-coli
Reversible unfolding of dimeric phosphofructokinase-2 from E. coli
Allosteric control of the oligomerization of phosphofructokinase-2 from E-coli.

Proyecto (15)

Biophysical and evolutionary assessment of the emergence of domain swapping within the Fox family of transcription factors
FOLDING OF PROTEINS ASSISTED BY DNA BINDING=> ROLE OF ELECTROSTATIC INTERACTIONS IN THE DOMAIN SWAPPING MECHANISM OF THE FOXP AND CSP FAMILIES
EVOLUTION OF RIBOKINASE SUPERFAMILY ENZYMES=> STRUCTURE-FUNCTION RELATIONSHIPS THAT DETERMINE SUBSTRATE SPECIFICITY, METAL ASSISTED MECHANISM AND PROTEIN STABILITY.
A COMPREHENSIVE MODEL FOR THE MECHANISM OF ALLOSTERIC REGULATION OF E. COLI PHOSPHOFRUCTOKINASE-2. INTEGRATION OF KINETIC, STRUCTURAL, DYNAMIC AND MECHANIC ASPECTS.
FILOGENIA, MECANISMO CATALITICO Y ESPECIFICIDAD DE SUSTRATO EN ENZIMAS DE LA SUPERFAMILIA RIBOQUINASA. IMPLICACIONES PARA LA EVOLUCION DE LA SUPERFAMILIA.
FORMACION E INTERCONVERSION DE ESTRUCTURAS CUATERNARIAS DE ENZIMAS=> IMPORTANCIA DE LAS INTERFACES DE Pfk-2 DE E. COLI PARA LA ESTABILIDAD, LA ACTIVIDAD CATALITICA Y LA REGULACION ALOSTERICA.
ANALISIS ESTRUCTURAL Y FUNCIONAL DE LOS SITIOS DE UNION DE LIGANDOS Y CONTROL ALOSTERICO DE LA OLIGOMERIZACION DE FOSFOFRUCTOQUINASA-2 DE E.COLI.
ASOCIACION DE SUBUNIDADES EN ENZIMAS OLIGOMERICAS. REGULACION ALOSTERICA DE FOSFOFRUCTOQUINASA-2 DE E. COLI
BASES ESTRUCTURALES DE LA REGULACION DE LA ACTIVIDAD DE LA FOSFOFRUCTOQUINASA-2 DE ESCHERICHIA COLI
MUTANTES DE ESCHERICHIA COLI CON FOSFOFRUCTOQUINASAS QUE DIFIEREN EN SUS PROPIEDADES REGULADAS. ESTUDIOS METABOLICOS Y ESTRUCTURALES
REGULACION IN VIVO DE LA GLICOLISIS Y GLUCONEOGENESIS EN CEPAS SILVESTRE Y MUTANTES DE ESCHERICHIA COLI
USO DE MUTANTES DE E. COLI PARA CONOCER LAS RELACIONES ENTRE EL FLUJO METABOLICO IN VIVO Y LAS PROPIEDADES IN VITRO DE LA FOSFOFRUCTOQUINASA Y LA FRUCTOSA-BISFOSFATASA.
SIGNIFICADO FISIOLOGICO DE LOS MECANISMOS DE REGULACION DE LAS ACTIVIDADES DE FOSFOFRUCTOQUINASA Y FRUCTOSA BISFOSFATASA.
MUTANTES BACTERIANAS EN EL ESTUDIO DE LOS MECANISMOS REGULATORIOS DE FOSFOFRUCTOQUINASA U FRUCTOSA BISFOFATASA.
PAPEL FISIOLOGICO DE LAS ISOENZIMAS.
31
Jorge Babul

UNIVERSIDAD DE CHILE

Santiago, Chile

19
Mauricio Baez

Assistant Professor

Bioquímica y Biología Molecular

UNIVERSIDAD DE CHILE

Santiago, Chile

16
Victoria Guixé

Titular Profesor

Biology

UNIVERSIDAD DE CHILE

Santiago, Chile

12
Ricardo Cabrera

Assitant Pofessor

Biology

UNIVERSIDAD DE CHILE

Santiago, Chile

7
CESAR RAMIREZ

Assistant Professor

Institute for Biological and Medical Engineering

Pontificia Universidad Catolica de Chile

Santiago, Chile

4
Christian Wilson

Associate professor

Bioquimica y Biologia Molecular

Universidad de Chile

Santiago, Chile

3
Exequiel Medina

Researcher

BIología

Universidad de Chile

Santiago, Chile

1
Jaime Rivas

Assistant Professor

Facultad de Ciencias

Universidad Mayor

Santiago, Chile

1
Diego Quiroga

Investigation assistant at Biochemistry Lab (Chem and Pharm Sciences Fac, Dr. Christian AM Wilson)

Universidad de Chile

Santiago, Chile

1
Javiera Reyes

Alumno Doctorado

Ingeniería

Pontificia Universidad Católica de Chile

Santiago, Chile

1
Jans Alzate

Associate Professor

Departamento de Bioinformática

UNIVERSIDAD DE TALCA

Talca, Chile

1
Gabriel Vallejos

Investigador postdoctoral

Departamento de Biología

Universidad de Chile

Santiago, Chile

1
Ricardo Zamora

Postdoctoral Research

Institute for Bioengineering of Catalonia (IBEC)

Barcelona, España

1
Víctor Castro

Profesor Asistente

Departamento de Biología

UNIVERSIDAD DE CHILE

Ñuñoa, Chile