Man

Xavier Horacio Figueroa Foessel

Associate Professor

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

Líneas de Investigación


Control Mechanisms of vasomotor tone, Intercellular communication in the wall of resistance arteries and arterioles, Regulation of nitric oxide signaling Regulation of blood flow distribution Control of arterial blood pressure

Educación

  •  Ciencias Fisiológicas, PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE. Chile, 2001

Experiencia Académica

  •   Research Associate Full Time

    University of Virginia

    Charlottesville, Estados Unidos

    2001 - 2006

Experiencia Profesional

  •   Research Associate Full Time

    University of Virginia

    Charlottesville, Estados Unidos

    2001 - 2006

Formación de Capital Humano


Undergraduate students:
Pablo S. Gaete. Los canales de K+ activados por calcio son esenciales para la producción de NO inducida por Acetilcolina (Calcium-activated K+ channels are essential for the acetylcholine-induced NO production). Student of Biology at School of Biological Sciences, Pontificia Universidad Católica de Chile, 2007.

Felipe Ortiz. Los canales de Na+ dependientes de voltaje participan en el mecanismo vasodilatador endotelial activado por acetilcolina (Voltage-dependent Na+ channels participate in the endothelial cell vasodilator mechanism activated by acetylcholine). Student of Biology at School of Biological Sciences, Pontificia Universidad Católica de Chile, 2007.

Mauricio A. Lillo. Participación de los canales formados por conexinas en la transmisión intercelular del óxido nítrico en la pared vascular (Participation of connexin-foormed channels in the intercellular transmission of nitric oxide in the vascular wall). Student of Biochemistry at School of Biological Sciences, Pontificia Universidad Católica de Chile, 2011.

Manuel Muñoz. Regulación del acoplamiento neurovascular por óxido nítrico (Regulation of neurovascular coupling by nitric oxide). Student of Biology at School of Biological Sciences, Pontificia Universidad Católica de Chile, 2013.

Ph.D Students:
Pablo S. Gaete. Disfunción microvascular inducida por la liberación de CGRP desde las aferencias sensoriales primarias (Microvascular dysfunction induced by CGRP release from primary sensory nerves). Ph.D. Program in Physiological Science, Pontificia Universidad Católica de Chile. Finished 2014.

Mauricio A. Lillo. Mecanismos de activación y coordinación longitudinal de las respuestas vasodilatadoras dependientes del endotelio en arterias de resistencia (Mechanisms of activation and longitudinal coordination of endothelium-dependent vasodilator responses in resistance arteries). Ph.D. Program in Physiological Science, Pontificia Universidad Católica de Chile. Finished 2017.
Thesis Work recognized as: “Award for excellence in Ph.D. Thesis Work 2017” in the area of “Biology and Health Sciences”, School of Doctoral Programs, Pontificia Universidad Católica de Chile.

Mariela Puebla. Control del acoplamiento neurovascular a través de la regulación de los hemicanales de conexinas o panexinas por la producción de óxido nítrico en los astrocitos (Neurovascular coupling control through connexin or pannexin regulation by nitric oxide production in astrocytes). Ph.D. Program in Physiological Science, Pontificia Universidad Católica de Chile. Finished 2018.

Pía Burboa. Mecanismos de activación de la entrada de calcio en la respuesta de hiperpermeabilidad en vénulas postcapilares (Mechanisms of Ca2+ influx activation in the response to hyperpermeability in postcapillary venules). Ph.D. Program in Physiological Science, Pontificia Universidad Católica de Chile. Finished 2020.

Victor Lazo. Mecanismos que participan en el desarrollo de la disfunción endotelial asociada a estrés oxidativo (Mechanisms that participate in the development of the endotelial dysfunction associated to oxidative stress). Ph.D. Program in Physiological Science, Pontificia Universidad Católica de Chile. In progress.

Manuel Francisco Muñoz Camus. Mecanismos glutamatérgicos de control y coordinación del tono vasomotor en arterias de resistencia cerebrales y periféricas (Glutamatergic mechanisms of control and coordination of vasomotor tone in cerebral and peripheric resistance arteries). Ph.D. Program in Physiological Science, P. Universidad Católica de Chile. Finished 2020.

Hilda Espinoza. Mecanismos de activación y coordinación de las señales de Ca2+ involucradas en la migración de las células endoteliales (Activation and coordination mechanisms of the Ca2+ signals involved in endothelial cell migration). Ph.D. Program in Physiological Science, P. Universidad Católica de Chile. Finished 2020.


Premios y Distinciones

  •   Ph.D. Program Scholarship

    PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

    Chile, 1996

    Scholarship provides by the P. Universidad Catolica de Chile for Tuition and maintenance to stay in the Ph.D. program

  •   Best Scientific Publication 1997 Award

    Santiago’s Medical Association

    Chile, 1997

    Award from the Santiago’s Medical Association to the Best Scientific Publication of the year 1997

  •   Ph.D. Scholarship

    CONICYT

    Chile, 1997

    Ph.D. Scholarship for Tuition and maintenance

  •   Merck Sharp & Dohme Young Investigator Award

    2001 Merck Sharp & Dohme at the XIV Scientific

    Chile, 2001

    Merck Sharp & Dohme Young Investigator Award at the XIV Scientific Meeting of The Inter-American Society of Hypertension, Santiago, Chile

  •   Hsueh-Hwa Wang Cardiovascular Section Travel Award

    APS Cardiovascular Section

    Estados Unidos, 2004

    Hsueh-Hwa Wang Cardiovascular Section Travel Award sponsored by the APS Cardiovascular Section at the Experimental Biology Meeting, Washington

  •   Best Scientific Work

    SOCIEDAD CHILENA DE CIENCIAS FISIOLOGICAS

    Chile, 2011

    Best scientific work at XXVI Reunión Anual Sociedad Chilena de Ciencias Fisiológicas.

  •   Mejor trabajo Científico International Gap Junction Conference

    International Gap Junction Conference

    Chile, 2014

    Mejor trabajo en formato Poster del International Gap Junction Conference 2014

  •   Mejor trabajo científico de la XXVI Reunión Anual de la Sociedad Chilena de Ciencias Fisiológicas

    SOCIEDAD CHILENA DE CIENCIAS FISIOLOGICAS

    Chile, 2011

    Mejor trabajo científico de la XXVI Reunión Anual de la Sociedad Chilena de Ciencias Fisiológicas


 

Article (29)

Editorial: Cell Communication in Vascular Biology
Novel Pannexin-1-Coupled Signaling Cascade Involved in the Control of Endothelial Cell Function and NO-Dependent Relaxation
Design, characterization and quantum chemical computations of a novel series of pyrazoles derivatives with potential anti-proinflammatory response
Function of P2X4 Receptors Is Directly Modulated by a 1:1 Stoichiometric Interaction With 5-HT(3)A Receptors
CGRP signalling inhibits NO production through pannexin-1 channel activation in endothelial cells
Critical contribution of Na+-Ca2+ exchanger to the Ca2+-mediated vasodilation activated in endothelial cells of resistance arteries
Pannexin channel and connexin hemichannel expression in vascular function and inflammation
Coordinated Endothelial Nitric Oxide Synthase Activation by Translocation and Phosphorylation Determines Flow-Induced Nitric Oxide Production in Resistance Vessels
De novo expression of connexin hemichannels in denervated fast skeletal muscles leads to atrophy
Diffusion of nitric oxide across cell membranes of the vascular wall requires specific connexin-based channels.
Lipopolysaccharide induces a fibrotic-like phenotype in endothelial cells
Ca2+-activated K+ channels of small and intermediate conductance control eNOS activation through NAD(P)H oxidase
Hemichannels in the Neurovascular Unit and White Matter Under Normal and Inflamed Conditions
NO production and eNOS phosphorylation induced by epinephrine through the activation of beta-adrenoceptors
Dissection of two Cx37-independent conducted vasodilator mechanisms by deletion of Cx40: electrotonic versus regenerative conduction
Are voltage-dependent ion channels involved in the endothelial cell control of vasomotor tone?
HISTAMINE REDUCES GAP JUNCTIONAL COMMUNICATION OF HUMAN TONSIL HIGH ENDOTHELIAL CELLS IN CULTURE
Central role of connexin40 in the propagation of electrically activated vasodilation in mouse cremasteric arterioles in vivo.
ACH-INDUCED ENDOTHELIAL NO SYNTHASE TRANSLOCATION, NO RELEASE AND VASODILATATION IN THE HAMSTER MICROCIRCULATION IN VIVO
Clonidine-induced nitric oxide-dependent vasorelaxation mediated by endothelial alpha(2)-adrenoceptor activation
In vivo assessment of microvascular nitric oxide production and its relation with blood flow
Stimulation of NO production and of eNOS phosphorylation in the microcirculation in vivo
Kinin B2 receptors mediate blockade of atrial natriuretic peptide natriuresis induced by glucose or feeding in fasted rats.
Rise in endothelium-derived NO after stimulation of rat perivascular sympathetic mesenteric nerves.
Croxatto's fifty-year pursuit: from pepsanurin to the discovery of a new kininogen-derived peptide (PU-D1).
Determination of nitric oxide production in the hamster cheek pouch microcirculation in vivo
La glucosa en conjunto con péptidos derivados de cininógenos podrían actuar desde el aparato digestivo como bloqueadores de la acción diurética-natriurética del ANP.
A peptide released by pepsin from kininogen domain 1 is a potent blocker of ANP-mediated diuresis-natriuresis in the rat.
A fragment of human kininogen containing bradykinin blunts the diuretic effect of atrial natriuretic Peptide

BookSection (2)

Connexin- and Pannexin-Mediated Vascular Signaling in Diabetes
Control and coordination of vasomotor tone in the microcirculation

Letter (1)

Are voltage-dependent ion channels involved in the endothelial cell control of vasomotor tone? - Reply

Proyecto (12)

Combining force spectroscopy and cellular omics reveals the molecular mechanism of crosstalking interaction between plasma membrane P2X4 and 5-HT3a receptors
PARACRINE EFFECT OF THE ENDOTHELIUM ON PROSTATE CANCER CELLS AND ITS ROLE DURING TUMOR PROGRESSION
CONTROL AND COORDINATION OF MICROVASCULAR VASOMOTOR TONE BY NITRIC OXIDE-DEPENDENT REGULATION OF CONNEXIN- AND PANNEXIN-FORMED GAP JUNCTION CHANNELS OR HEMICHANNELS
ROLE AND REGULATION OF HEMICHANNELS IN FUNCTIONAL RESPONSES OF INACTIVE, ACTIVE AND ACUTELY CACHEXIC ADULT SKELETAL MUSCLES.
COORDINATION OF MICROVASCULAR FUNCTION BY LONG DISTANCE ENDOTHELIAL CELL SIGNALING BASED ON CONNEXIN-MEDIATED COMMUNICATION AND VOLTAGE-DEPENDENT VASODILATOR MECHANISMS
Pro-inflammatory conditions increase the permeability of the cell membrane through pathways that offer new therapeutic targets for human diseases
MECANISMOS DE DISFUNCION ENDOTELIAL EN HIPERTENSION. RELACION FUNCIONAL ENTRE LA EXPRESION DEL CANAL DE SODIO EPITELIAL (ENAC) Y LA LOCALIZACION SUBCELULAR DE LA OXIDO NITRICO SINTASA ENDOTELIAL (ENOS).
Mecanismos endoteliales dependientes de voltaje para la propagación regenerativa de las respuestas vasodilatadoras
Participación de las arginasas en la disfunción endotelial característica de la hipertensión arterial
MECANISMOS DE SEÑALIZACION CELULAR PARA LA PROPAGACION DE LAS RESPUESTAS VASODILATADORAS.
Signaling and Transmission pathways for Conducted Vasodilation
PRODUCCION DE OXIDO NITRICO EN VASOS DE RESISTENCIA=> MECANISMOS DE TRANSDUCCION Y REGULACION CELULAR

Review (5)

Connexins and Pannexins in Vascular Function and Disease
Control of the neurovascular coupling by nitric oxide-dependent regulation of astrocytic Ca2+ signaling
Functional Role of Connexins and Pannexins in the Interaction Between Vascular and Nervous System
Gap Junctions in the Control of Vascular Function
Vascular gap junctions in hypertension
36
Xavier Figueroa

Associate Professor

Departamento de Fisiologia

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

8
Juan Saez

Professor

Instituto de Neurociencias

Universidad de Valparaiso

Valparaíso, Chile

3
Daniel Gonzalez

PROFESOR ASOCIADO

CIENCIAS BASICAS BIOMEDICAS

UNIVERSIDAD DE TALCA

Talca, Chile

2
Juan Orellana

Associate Professor

Departamento de Neurología

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

2
Alvaro Becerra

Profesor Asociado

Ciencias Químico y Biológicas

Universidad Bernardo O'Higgins

Santiago, Chile

1
Alvaro Elorza

ASSOCIATE PROFESSOR

INSTITUTE OF BIOMEDICAL SCIENCES

UNIVERSIDAD ANDRES BELLO

Santiago, Chile

1
Carlos Puebla

Profesor Asistente

Universidad de O'Higgins

Rancagua, Chile

1
Ricardo Fernandez

Profesor Asociado A

Salud

Universidad de Los Lagos

Osorno, Chile

1
Felipe Simon

Profesor Titular

Department of Biological Sciences

UNIVERSIDAD ANDRES BELLO FAC DE CS BIOLOGICAS, DPTO DE CS BIOLOGICAS

Santiago, Chile

1
Daniel Rojas

Profesor

Universidad Diego Portales

Santiago, Chile

1
Claudio Cabello

Full Professor

Ciencias Biologicas

UNIVERSIDAD ANDRES BELLO

Santiago, Chile

1
Luis Cea

Profesor programa teaching

Instituto de Ciencias Biomédicas

Universidad Autónoma de Chile

Santiago, Chile

1
César Echeverría

DIRECTOR DE INVESTIGACIÓN

Medicina

Universidad de Atacama

COPIAPO, Chile

1
ramon latorre

Profesor

Instituto de Neurociencia

Universidad de Valparaíso

5, Chile

1
Carlos Puebla

Assistant Professor

Universidad de O'Higgins

Santiago, Chile

1
Victor Cortes

Associate professor

Nutrition, Diabetes and Metabolism

Pontificia Universidad Católica de Chile

Santiago, Chile

1
Juan Pedemonte

Profesor Clinico Asistente

Anestesiologia

Pontificia Universidad Católica de Chile

Santiago, Chile

1
Nelson Barrera

Associate Professor

Physiology

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

Santiago, Chile

1
Ricardo Fernández

Associate Professor

Salud

Universidad de Los Lagos

Osorno, Chile