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HELMUTH ALBERTO SANCHEZ RIQUELME

INVESTIGADOR ADJUNTO

CENTRO INTERDISCIPLINARIO DE NEUROCIENCIAS DE VALPARAISO

VALPARAISO, Chile

FISIOLOGIA; NEUROCIENCIAS; BIOFISICA

DOCTORADO en CIENCIAS BIOLOGICAS, PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE. Chile, 2008
LICENCIATURA en CS.BIOLOGICAS, PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE. Chile, 2000

INVESTIGADOR ASOCIADO Full Time

ALBERT EINSTEIN COLLEGE OF MEDICINE

AECOM, School of Medicine

Nueva York, Estados Unidos

2015 - 2016

POSTDOCTORADO Full Time

ALBERT EINSTEIN COLLEGE OF MEDICINE

Nueva York, Estados Unidos

2008 - 2015

Experience in the following techniques:
Cell culture management ( Contreras et al. 2002, Sanchez et al., 2009, Sanchez et al., 2010, Abbott et al., 2023, Waisblutt et al., 2023).
Electrophysiology, TVEC and single whole-cell records (Sanchez et al., 2009, Sanchez et al., 2010, Rubinos et al., 2012, Sanchez et al., 2013, 2014, 2016).
Immunotransference (Contreras et al, 2002, Sanchez et al., 2009, 2013)
Immunofluorescence (Eugenin et al., 2007, Sanchez et al., 2009, Sanchez and Verselis, 2014)

https://cinv.uv.cl/members/helmuth-sanchez/

10.51445/sja.auditio.vol6.2022.0082


Expression of KID syndromic mutation Cx26S17F produces hyperactive hemichannels in supporting cells of the organ of Corti Abbott, Ana C.; Garcia, Isaac E.; Villanelo, Felipe; Flores-Munoz, Carolina; Ceriani, Ricardo; Maripillan, Jaime; Novoa-Molina, Joel; Figueroa-Cares, Cindel; Perez-Acle, Tomas; Saez, Juan C.; Sanchez, Helmuth A.; Martinez, Agustin D. Article ISI FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2023)
MATE1 expression in the cochlea and its potential involvement in cisplatin cellular uptake and ototoxicity Waissbluth, Sofia; Martinez, Agustin D.; Figueroa-Cares, Cindel; Sanchez, Helmuth A.; Maass, Juan C. Article ISI ACTA OTO-LARYNGOLOGICA (2023)
Supporting Cells and Their Potential Roles in Cisplatin-Induced Ototoxicity Waissbluth, Sofia; Maass, Juan Cristobal; Sanchez, Helmuth A.; Martinez, Agustin D. Article ISI FRONTIERS IN NEUROSCIENCE (2022)
An Update on Connexin Gap Junction and Hemichannels in Diabetic Retinopathy Gonzalez-Casanova, Jorge; Schmachtenberg, Oliver; Martinez, Agustin D.; Sanchez, Helmuth A.; Harcha, Paloma A.; Rojas-Gomez, Diana Article ISI INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)
Restraint of Human Skin Fibroblast Motility, Migration, and Cell Surface Actin Dynamics, by Pannexin 1 and P2X7 Receptor Signaling Flores-Munoz, Carolina; Maripillan, Jaime; Vasquez-Navarrete, Jacqueline; Novoa-Molina, Joel; Ceriani, Ricardo; Sanchez, Helmuth A.; Abbott, Ana C.; Weinstein-Oppenheimer, Caroline; Brown, Donald I.; Cardenas, Ana Maria; Garcia, Isaac E.; Martinez, Agustin D. Article ISI INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)
Syndromic deafness mutations at Asn 14 differentially alter the open stability of Cx26 hemichannels Sanchez, Helmuth A.; Slavi, Nefeli; Srinivas, Miduturu; Verselis, Vytas K. Article ISI JOURNAL OF GENERAL PHYSIOLOGY (2016)
Aberrant Cx26 hemichannels and keratitis-ichthyosis-deafness syndrome: insights into syndromic hearing loss Sanchez, Helmuth A.; Verselis, Vytas K. Article ISI FRONTIERS IN CELLULAR NEUROSCIENCE (2014)
Altered Inhibition of Cx26 Hemichannels by pH and Zn2+ in the A40V Mutation Associated with Keratitis-Ichthyosis-Deafness Syndrome Sanchez, Helmuth A.; Bienkowski, Rick; Slavi, Nefeli; Srinivas, Miduturu; Verselis, Vytas K. Article ISI JOURNAL OF BIOLOGICAL CHEMISTRY (2014)
The D50N mutation and syndromic deafness: Altered Cx26 hemichannel properties caused by effects on the pore and intersubunit interactions Sanchez, Helmuth A.; Villone, Krista; Srinivas, Miduturu; Verselis, Vytas K. Article ISI JOURNAL OF GENERAL PHYSIOLOGY (2013)
Mechanism of inhibition of connexin channels by the quinine derivative N-benzylquininium Rubinos, Clio; Sanchez, Helmuth A.; Verselis, Vytas K.; Srinivas, Miduturu Article ISI JOURNAL OF GENERAL PHYSIOLOGY (2012)
Regulation of Intercellular Calcium Signaling Through Calcium Interactions with Connexin-Based Channels Orellana J.A.; Schalper K.A.; Figueroa, V.; SANCHEZ, H.A.; Sáez, J.C. Article ISI SCOPUS GLIAL CELLS IN HEALTH AND DISEASE OF THE CNS (2012)
Hemichannels in the Neurovascular Unit and White Matter Under Normal and Inflamed Conditions Orellana, JA; Figueroa, XF; Sanchez HA; Contreras-Duarte, S; Velarde, V; Sáez JC Article ISI SCOPUS CNS and Neurological Disorders - Drug Targets (2011)
Connexin 43 hemichannels mediate the Ca2+ influx induced by extracellular alkalinization Schalper, KA; Sanchez HA; Lee, SC; Altenberg, GA; Nathanson, MH; Sáez JC Article ISI SCOPUS American Journal of Physiology - Cell Physiology (2010)
Differentially altered Ca(2+) regulation and Ca(2+) permeability in Cx26 hemichannels formed by the A40V and G45E mutations that cause keratitis ichthyosis deafness syndrome Sanchez, Helmuth A.; Mese, Guelistan; Srinivas, Miduturu; White, Thomas W.; Verselis, Vytas K. Article ISI JOURNAL OF GENERAL PHYSIOLOGY (2010)
Metabolic inhibition increases activity of connexin-32 hemichannels permeable to Ca2+ in transfected HeLa cells Sanchez HA; Orellana, JA; Verselis, VK; Sáez JC Article ISI SCOPUS AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY (2009)
Inflammatory conditions induce gap junctional communication between rat Kupffer cells both in vivo and in vitro Eugenin, EA; González HE; Sanchez, HA; Branes, MC; Saez JC Article CELLULAR IMMUNOLOGY (2007)
Inflammatory conditions induce gap junctional communication between rat Kupffer cells both in vivo and in vitro Eugenin, EA; González HE; Sanchez HA; Branes, MC; Sáez JC Article ISI SCOPUS CELLULAR IMMUNOLOGY (2007)
Role of connexin-based gap junction channels and hemichannels in ischemia-induced cell death in nervous tissue Contreras, JE; Sanchez HA; Véliz LP; Bukauskas, FF; BENNETT, MVL; Sáez JC Article ISI BRAIN RESEARCH REVIEWS (2004)
Role of connexin-based gap junction channels and hemichannels in ischemia-induced cell death in nervous tissue Contreras, JE; Sanchez, HA; Veliz, LP; Bukauskas, FF; Bennett, MVL; Saez JC Article Brain Research Reviews (2004)
Metabolic inhibition induces opening of unapposed connexin 43 gap junction hemichannels and reduces gap junctional communication in cortical astrocytes in culture Contreras, JE; Sanchez HA; Eugenin, EA; Speidel, D; Theis, M; Willecke K.; Bukauskas, FF; BENNETT, MVL; Sáez JC Article ISI PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2002)
Metabolic inhibition induces opening of unapposed connexin 43 gap junction hemichannels and reduces gap junctional communication in cortical astrocytes in culture Contreras, JE; Sanchez, HA; Eugenin, EA; Speidel, D; Theis, M; Willecke, K; Bukauskas, FF; Bennett, MVL; Saez JC Article PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2002)


IDENTIFICATION OF CONGENITAL DEAFNESS MUTATIONS IN CHILE SANCHEZ, H.A. Proyecto (2018)


Redox-mediated regulation of connexin proteins; focus on nitric oxide Garcia, IE; Sanchez, HA; Martinez, AD; Retamal, MA Review ISI SCOPUS BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES (2018)