Man

Ana María Cárdenas Díaz

Professor

UNIVERSIDAD DE VALPARAÍSO

Valparaíso, Chile

Líneas de Investigación


Exocitosis, endocitosis, tráfico vesicular, miopatías, Síndrome de Down

Educación

  •  Químico Farmacéutico, UNIVERSIDAD DE CHILE. Chile, 1984
  •  Farmacologia, Universidad Complutense de Madrid. España, 1988

Experiencia Académica

  •   Professor Full Time

    UNIVERSIDAD DE VALPARAISO

    Ciencias

    Valparaíso, Chile

    1988 - A la fecha

  •   Post-doctor Full Time

    NATIONAL INSTITUTE OF HEALTH

    NIDDK

    Bethesda, Estados Unidos

    1992 - 1994

  •   Investigador Part Time

    Centro Interdisciplinario de Neurociencia de Valparaíso

    Chile

    2010 - A la fecha

  •   Tesista de Doctorado Full Time

    Universidad Autónoma de Madrid

    Medicina

    España

    1985 - 1988

Experiencia Profesional

  •   Professor Full Time

    Universidad de Valparaíso

    Chile

    1988 - A la fecha

Formación de Capital Humano


2019. Hugo Almarza Salazar. Alteraciones en el tráfico vesicular en líneas celulares de pacientes portadores de disferlinopatía. Magíster en Ciencias Biológicas, mención Neurociencia. Universidad de Valparaíso.
2019. Paz García Campos. Efecto de una dieta con N-acetil-cisteína sobre parámetros de estrés oxidativo y la progresión de disferlinopatía en modelo animal. Magíster en Ciencias Mención en Radicales Libres y Biomedicina. Universidad de Valparaíso.
2018. Fernando Hinostroza. Impact of dynamin-2 R465W mutation linked to centronuclear myopathy on dynamin interactions, helix dimer, and helix structure: a study using molecular dynamics simulations. Doctorado en Ciencias mención Neurociencias. Universidad de Valparaíso.
2017. Ximena Báez. Rol de disferlina en el remodelamiento de la F-actina cortical en células musculares; implicancia en modelos in vitro de disferlinopatias. Magíster en ciencias médicas, mención Biología celular y molecular. Universidad de Valparaíso.
2016. Jacqueline Vásquez Navarrete. Disfunción en la exocitosis de vesículas secretoras en un modelo celular del síndrome de Down. Magíster en Ciencias Biológicas, mención Neurociencia. Universidad de Valparaíso.
2016. María José Guerra. Rol de la Subunidad ? de los canales de Ca+2 voltaje dependientes en la expresión de los canales en células Cromafines de bovino. Magíster en Ciencias Biológicas, mención Neurociencia Universidad de Valparaíso.
2016. Irina Galli González. Desempeño de tareas de Memoria y de Respuesta emocional de mujeres jóvenes durante el ciclo menstrual. Magíster en Ciencias Biológicas, mención Neurociencia. Universidad de Valparaíso.
2013. Arlek González. Dynamin-2 regulates the late steps of exocytosis in adrenal chromaffin cells through a mechani9sm that involves actin polymerization. Doctorado en Ciencias mención Neurociencias. Universidad de Valparaíso.
2013. Natalia Barraza. Hiperfosforilación de proteína tau en líneas celulares de cerebro de ratón con trisomía 16, modelo celular del síndrome de Down . Magíster en Ciencias Biológicas, mención Neurociencia. Universidad de Valparaíso.
2013. Alfredo Cordero. Comorbilidad psiquátrica, rendimiento escolar en adolescentes con epilepsia. Magíster en Ciencias Biológicas, mención Neurociencia. Universidad de Valparaíso.


Premios y Distinciones

  •   Programa de Becas para estudiantes de Iberoamérica

    Instituto de Cooperación Iberoamericana

    Chile, 1985

    Beca para realizar estudios de doctorado en España

  •   Pew Latin American Fellows Program

    The Pew Charitable Trusts

    Estados Unidos, 1992

    The Pew Latin American Fellows Program in the Biomedical Sciences provides support for young scientists from Latin America to receive postdoctoral training in the United States.


 

Article (28)

Ca 2+ -Independent and Voltage-Dependent Exocytosis in Mouse Chromaffin Cells
N-Acetylcysteine Reduces Skeletal Muscles Oxidative Stress and Improves Grip Strength in Dysferlin-Deficient Bla/J Mice
Defects in G-Actin Incorporation Into Filaments in Myoblasts Derived From Dysferlinopathy Patients Are Restored by Dysferlin C2 Domains
The Ca 2+ Channel Subunit Ca V β2a-subunit Down-Regulates Voltage-Activated Ion Current Densities by Disrupting Actin-Dependent Traffic in Chromaffin Cells
RCAN1 Knockdown Reverts Defects in the Number of Calcium-Induced Exocytotic Events in a Cellular Model of Down Syndrome
Dynamin-2 mutations linked to Centronuclear Myopathy impair actin-dependent trafficking in muscle cells
Knockdown of Myo-Inositol Transporter SMIT1 Normalizes Cholinergic and Glutamatergic Function in an Immortalized Cell Line Established From the Cerebral Cortex of a Trisomy 16 Fetal Mouse, an Animal Model of Human Trisomy 21 (Down Syndrome)
Knockdown of Myo-Inositol Transporter SMIT1 Normalizes Cholinergic and Glutamatergic Function in an Immortalized Cell Line Established from the Cerebral Cortex of a Trisomy 16 Fetal Mouse, an Animal Model of Human Trisomy 21 (Down Syndrome).
The F-Actin Binding Protein Cortactin Regulates the Dynamics of the Exocytotic Fusion Pore through its SH3 Domain
Broadening The Imaging Phenotype of Dysferlinopathy at Different Disease Stages
Dysferlin Function in Skeletal Muscle: Possible Pathological Mechanisms and Therapeutical Targets in Dysferlinopathies
Overexpressed Down Syndrome Cell Adhesion Molecule (DSCAM) Deregulates P21-Activated Kinase (PAK) Activity in an In Vitro Neuronal Model of Down Syndrome: Consequences on Cell Process Formation and Extension
Sustained Exocytosis after Action Potential-like Stimulation at Low Frequencies in mouse Chromaffin Cells Depends on a Dynamin-Dependent Fast Endocytotic Process
The absence of dysferlin induces the expression of functional connexin-based hemichannels in human myotubes
Dynamin-2 in nervous system disorders
Dynamin-2 in nervous system disorders.
Pannexin 1 channels: new actors in the regulation of catecholamine release from adrenal chromaffin cells
Pannexin 1 Regulates Bidirectional Hippocampal Synaptic Plasticity in Adult Mice
Src kinases regulate de novo actin polymerization during exocytosis in neuroendocrine chromaffin cells
Src kinases regulate de novo actin polymerization during exocytosis in neuroendocrine chromaffin cells
Dynamin-2 Function and Dysfunction Along the Secretory Pathway.
Dynamin-2 Regulates Fusion Pore Expansion and Quantal Release through a Mechanism that Involves Actin Dynamics in Neuroendocrine Chromaffin Cells
Dynamin-2 Regulates Fusion Pore Expansion and Quantal Release through a Mechanism that Involves Actin Dynamics in Neuroendocrine Chromaffin Cells
Altered Voltage Dependent Calcium Currents in a Neuronal Cell Line Derived From the Cerebral Cortex of a Trisomy 16 Fetal Mouse, an Animal Model of Down Syndrome
Rapid endocytosis and vesicle recycling in neuroendocrine cells
The Association of Dynamin with Synaptophysin Regulates Quantal Size and Duration of Exocytotic Events in Chromaffin Cells
The Association of Dynamin with Synaptophysin Regulates Quantal Size and Duration of Exocytotic Events in Chromaffin Cells
Recent advances in chromaffin cell biology: Summing up the last international symposium on chromaffin cell biology

BookSection (1)

Hereditary Myopathies

Proyecto (15)

ROLE OF DYSFERLIN IN CYTOSKELETAL ACTIN REMODELING AND ITS IMPACT ON VESICLE TRAFFICKING AND MEMBRANE REPAIR IN MUSCULAR DYSTROPHY LINKED TO DYSFERLIN MUTATIONS.
Centro Interdisciplinario de Neurociencia de Valparaíso
ROLE OF OVEREXPRESSED DSCAM AND APP IN PAK KINASE DERREGULATION, AND THE CONSEQUENT NEURONAL DYSFUNCTION IN INVITRO MODELS OF DOWN SYNDROME=> A QUEST FOR CELLULAR THERAPEUTICAL TARGETS.
Molecular and cellular mechanisms of dysferlin-related muscular dystrophy=> From genetics to therapy.
Centro Interdisciplinario de Neurociencia de Valparaíso
CONTRIBUTION OF SRC KINASES, N-WASP AND CORTACTIN TO CORTICAL ACTIN REARRANGEMENT AND EXOCITOSIS DYNAMICS IN CHROMAFFIN CELLS.
REGULATION OF GAP JUNCTIONS, HEMICHANNELS, AND PANNEXIN CHANNELS AND THEIR EFFECTS ON CALCIUM-REGULATED EXOCYTOSIS IN NEUROENDOCRINE CELLS=> A ROLE IN SHORT TERM PLASTICITY
Molecular mechanisms of secretory granule membrane endocytosis in neuroendocrine cells=> functional importance of dynamin’s isoforms
ROLE OF DYRK1A AND DSCR1 OVEREXPRESSION IN GENETIC REGULATORY CIRCUITS AND CELLULAR DYSFUNCTION OF IMMORTALIZED NEURONAL CELLS DERIVED FROM THE TRISOMY 16 MOUSE, AN ANIMAL MODEL OF HUMAN DOWN SYNDROME=> POSSIBLE THERAPEUTIC TARGETS
MECANISMOS MOLECULARES QUE GOBIERNAN EL KISS-AND-RUN DINAMINA-DEPENDIENTE=> PARTICIPACION DE SINAPTOFISINA Y PROTEINAS CON DOMINIO SH3.
GENE DOSAGE EFFECTS IN CHOLINERGIC AND GLUTAMATERGIC DYSFUNCTION OF IMMORTALIZED NEURONAL CELLS DERIVED FROM THE TRISOMY 16 MOUSE, AN ANIMAL MODEL OF HUMAN DOWN SYNDROME
CAMBIOS EN LA EFICIENCIA SECRETORA DEBIDO A REDISTRIBUCION DE ZONAS SECRETORAS ACTIVAS Y CANALES CALCIO EN CELULAS CROMAFINES DIFERENCIADAS
CONTRIBUCION DE DIFERENTES SUBTIPOS DE CANALES DE CALCIO VOLTAJE-DEPENDIENTES A LA REGULACION GENICA EN CELULAS CROMAFINES BOVINAS=> VIAS DE TRASDUCCION DE SENALES IMPLICADAS
LINEAS CELULARES INMORTALES DERIVADAS DE SISTEMA NERVIOSO DEL RATON CON TRISOMIA 16, MODELO ANIMAL DE LA TRISOMIA 21 HUMANA=> POSIBLES MODELOS FISIOPATOLOGICOS
EFECTO A LARGO PLAZO DEL INCREMENTO DE CALCIO INTRACELULAR Y DE LA ACTIVACION DE LA PROTEINKINASA C SOBRE LA EXPRESION DE SNAP-25 Y LA LIBERACION DE NEUROTRANSMISOR.

Review (3)

How does the stimulus define exocytosis in adrenal chromaffin cells?
How the stimulus defines the dynamics of vesicle pool recruitment, fusion mode, and vesicle recycling in neuroendocrine cells
Role of Tau Protein in Neuronal Damage in Alzheimer's Disease and Down Syndrome
19
Ana Cárdenas

Professor

UNIVERSIDAD DE VALPARAÍSO

Valparaíso, Chile

5
Pablo Caviedes

Full professor

ICBM

PROGRAMA DE FARMACOLOGÍA MOLECULAR Y CLÍNICA, ICBM, FAC. DE MEDICINA, U. DE CHILE

Santiago, Chile

2
Alan Neely

Pofesor

Instituto de Neurociencias

Universidad de Valparaíso

Valparaiso, Estados Unidos

1
Jorge Bevilacqua

Profesor Titular

Neurología y Neurocirugía

UNIVERSIDAD DE CHILE, FACULTAD DE MEDICINA, ESCUELA DE MEDICINA

Santiago, Chile

1
Alvaro Ardiles

Assistant Professor

Medicine

Universidad de Valparaíso

Valparaiso, Chile

1
Ricardo Delgado

Profesor Adjunto

Biología

UNIVERSIDAD DE CHILE, FACULTAD DE CIENCIAS, DEPARTAMENTO DE BIOLOGIA

Santiago, Chile