
Daniel Rodrigo Aguayo Villegas
Assistant Professor
UNIVERSIDAD ANDRES BELLO
Santiago, Chile
• Molecular Biophysics (main interest). • Bioinformatics • Computer vision • Health Sciences.
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Biochemistry, Universidad Andrés Bello . Chile, 2006
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Biochemistry, Universidad Andrés Bello. Chile, 2009
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Biochemist, Universidad Andrés Bello. Chile, 2009
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Applied Science, Universidad de Talca. Chile, 2012
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Bioinformatic Engineering Career Development Committee Full Time
Universidad Andrés Bello
De Ciencias Biológicas
Santiago, Chile
2012 - A la fecha
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Academic board Member Full Time
Universidad Andrés Bello
De Ciencias Biológicas
Santiago, Chile
2013 - A la fecha
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Instructor Full Time
Universidad Andrés Bello
de Ciencias Biológicas
Santiago, Chile
2012 - 2013
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Principal Investigator Full Time
Universidad Andrés Bello
de Ciencias Biológicas
Santiago, Chile
2014 - A la fecha
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Academic Board Member Full Time
UNIVERSIDAD ANDRES BELLO
Ciencias de la Vida
Chile
2018 - A la fecha
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Academic Secretary. Full Time
UNIVERSIDAD ANDRES BELLO
Life Science
Chile
2020 - A la fecha
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Young Researcher Full Time
Universidad de Talca
Talca, Chile
2009 - 2011
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Young Researcher Full Time
Universidad de Valparaíso
Valparaíso, Chile
2013 - A la fecha
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Principal Investigator Full Time
Universidad Andrés Bello
Santiago, Chile
2014 - A la fecha
PostDoctorate Advisoring
2019-23 Romina Sepulveda, Prebiotic membranes Simulations.
2020 Luis Pinuer, Computer Vision for AgroIndustry.
Ph.D.
2021- Advisor. Felipe Gómez. Bionformatics and Systems Biology Program. Universidad Andrés Bello.
2016- Co-Advisor: Ana Inostroza. Molecular Bioscience Program. Universidad Andrés Bello.
Master
• 2017-2018 Advisor Simón Correa, Biochemistry Master. Universidad Andrés Bello.
• 2018- Advisor Belén Navarro, Biochemistry Master. Universidad Andrés Bello.
• 2017- Advisor Mackarenna Alarcón, Biochemistry Master. Universidad Andrés Bello.
• 2015-2016 Advisor Javier Salazar, Biochemistry Master. Universidad Andrés Bello. (Honored as Best Thesis by the Chilean Biochemistry Student Council)
• 2014-2016 Principal Advisor Jaime Huerta Acuña, Biochemistry Master. Universidad Andrés Bello.
Undergraduate
• 2018 Institutional Advisor. Consuelo Bello. Bioinformatics Engineer. Universidad Andrés Bello.
• 2018 – Advisor Felipe Rojas. Biotechnological Engineer. Universidad Andrés Bello.
• 2017 Advisor Simón Correa, Biochemistry. Universidad Andrés Bello.
• 2016- Advisor Belén Navarro, Biochemistry. Universidad Andrés Bello.
• 2016- Advisor Mackarenna Alarcón, Biochemistry. Universidad Andrés Bello.
• 2013 Advisor Jaime Huerta Acuña, Biochemistry. Universidad Andrés Bello.
• 2013 Advisor Javier Salazar, Biochemistry. Universidad Andrés Bello.
• 2011. Co-Advisor Luis Felipe Monsalves Otarola. Inserción De Drogas En Dendrímeros De Pamam: Análisis De Las Energías De Interacción. Escuela Ing. En Bioinformatica. Universidad de Talca.
• 2011. Co-Advisor Paz Tapia Ramirez.Estudio De Las Propiedades Estructurales Del Proceso De Hinchado Y Deshinchado Del Dendrímero Pamam G4. Escuela Ing. En Bioinformatica. Universidad de Talca.
Trainees
• 2018. Javier Salas. Programming for Computational Biology methods trainee, Bioinformatic Engineer. Universidad Andrés Bello.
• 2018. Juan Pablo Rojas. Programming for Computational Biology methods trainee, Bioinformatic Engineer. Universidad Andrés Bello.
• 2014. Cristobal Aravena. Bioinformatics applied to Biology problems trainee, Biochemistry School. Universidad Andrés Bello.
• 2017-2018. Felipe Becerra Gomez. Computational Biology methods trainee, Bioinformatic Engineer. Universidad Andrés Bello.
• 2017. Consuelo Bello. Computational Biology methods trainee, Bioinformatic Engineer. Universidad Andrés Bello.
• 2016. Melissa Alegría. Advanced Structural Bioinformatics Methods. Biophysics and Computational Biology Ph. D. Program. Universidad de Valparaiso.
• 2014-2018. Baltazar Zepeda. Digital Imaging for Fruit ripening detection. Trainee, Biochemistry Master. Universidad Andrés Bello. (Principal Advisor Reinaldo Campos Ph.D. Chair Vegetal Biotechnology Center, UNAB)
• 2015. Adriana Miranda, Consuelo Bello. Molecular Biology methods trainee, Bioinformatic Engineer.. Universidad Andrés Bello.
• 2015. Consuelo Bello. Molecular Biology methods trainee, Bioinformatic Engineer.. Universidad Andrés Bello.
• 2014. Mackarenna Alarcón, Belén Navarro. Bioinformatics applied to Biology problems trainee, Biochemistry Master. Universidad Andrés Bello.
• 2014. Belén Navarro. Experimental Biochemistry trainee, Biochemistry Master. Universidad Andrés Bello.
• 2015. Simón Correa Martelli. Data Mining Applied to Binge Eating Disorders, Biochemistry Master. Universidad Andrés Bello.
• 2015. Simón Correa Martelli. Molecular dynamics trainee, Biochemistry Master. Universidad Andrés Bello.
• 2014. Enzo Viera Fica. Deployment of Bioinformatics databases. Escuela Ing. En Bioinformatica. Universidad de Talca.
• 2013. Javier Salazar. Experimental Biochemistry trainee, Biochemistry Master. Universidad Andrés Bello.
• 2013. Alejandro Vallejos. Experimental Biochemistry trainee, Biochemistry Master. Universidad Andrés Bello.
• 2013. Lorena Cerda. Theoretical Biophysics. , Biochemistry Master. Universidad Andrés Bello.
International, Courses and Meeting Organizers
Workshop “Combining Cryo-Electron Microscopy & Biomolecular Simulations Discoveries Through a Computer Microscope” (4 days, January 2014)
Campus Quintay, Center for Bionformatics & Integrative Biology. Universidad Andrés Bello
Professors: Christophe Chipot, PhD.Illinois University at Urbana-Champaign. JC Gumbart, PhD. Georgia Institute of Technology Arne Möller, PhD. Aarhus Universit
Organizers: PhD. Daniel Aguayo,PhD, Fdo Danilo González-Nilo.
Advanced course in free energy calculation: practice and theory (December 2008) Center for Bioinformatics and Molecular Simulation,
Universidad de Talca (Talca, Chile)
Professor: Christophe Chipot, PhD (Universitè Henri Poincarè, France)
Organizers: PhD. Daniel Aguayo,PhD, Fdo Danilo González-Nilo.
Implementation, visualization and analysis of molecular dynamics simulations (December 2008)
Center for Bioinformatics and Molecular Simulation, Universidad de Talca (Talca, Chile)
Professor: Marcos Sotomayor, PhD (Harvard University, USA)
Organizers: PhD. Daniel Aguayo,PhD, Fdo Danilo González-Nilo.
Molecular dynamics simulations (December 2007)
Center for Bioinformatics and Molecular Simulation, Universidad de Talca (Talca, Chile)
Professor: Chris Chipot, PhD (Christophe Chipot, PhD (Universitè Henri Poincarè, France)
Organizers: PhD. Daniel Aguayo,PhD, Fdo Danilo González-Nilo.
International
• The 5th Latin American Conference on Networked and Electronic Media. 2013 Chairman: Bioinformatics. Universidad Andrés Bello.
• Workshop : Applied Computational Biophysics 2013 Invitado.
Invited Instructor (5 days) Facultad de Ciencias Exactas, Fisicoquímicas y Naturales Departamento de Biología Molecular. Universidad Nacional De Río Cuarto
• Workshop Molecular Simulations ICAP 2012.
Bogotá. Colombia. Invited Instructor 35 hrs.
Universidad Nacional de los Andes. Bogotá. Colombia.
• Workshop “Acercando la bionforma?tica a los colegios 2011
Bionformatics for Elementary Students. 150 hrs.
Centro de Bionformática y simulación molecular. Universidad de Talca.
Liceo Marta Donoso. Talca.
• Bioinformática Estructural como herramienta Biotecnológica 2011
Escuela de Ingenieri?a en Biotecnología Vegetal, Campus Los Angeles.
Universidad de Concepción.
• VI Escuela de Invierno de Análisis Estocástico y Aplicaciones. "Desafíos Matemáticos en Simulación Molecular de Proteínas y de nanopartículas". 2010
Instituto de Sistemas Complejos de Valparaíso
Universidad de Valparaíso.
Courses y training
• Workshop “Integration of Drug Discovery and Drug Delivery: D4”. 2017. Dr. Serge Mignani,. Center for Bioinformatics and Integrative Biology, Universidad Andrés Bello.
• Workshop. “Beyond Kds: New computational and experimental methods to address challenges in drug discovery”. 2017 Dr. Chris Chipot, Dr. Chad A. Brautigam. Center for Bioinformatics and Integrative Biology, Universidad Andrés Bello.
• Workshop “Combining Cryo-Electron Microscopy & Biomolecular Simulations Discoveries Through a Computer Microscope” (4 days, January 2014)
Campus Quintay, Center for Bionformatics & Integrative Biology. Andrés Bello University.
Professors: Christophe Chipot, PhD.Illinois University at Urbana-Champaign. JC Gumbart, PhD. Georgia Institute of Technology Arne Möller, PhD. Aarhus Universit
Organizers: Daniel Aguayo,PhD; Fdo Danilo González-Nilo, PhD.
• Protein Structures and Functions: A Molecular and Biotechnological Vision (January 2011) Universidad de Concepción (Concepción, Chile)
Professors: Richard Garrat, PhD (Universidad Sao Paulo, Brazil); Roberto Sánchez, PhD (Mount Sinai Medical Center, USA); José Martínez, PhD (Universidad de Concepción,
Chile); and Marta Bunster, PhD (Universidad de Concepción, Chile).
• Plant Biophysics (January 2010)
Universidad de Talca (Talca, Chile)
Professor: Ingo Dréyer, PhD (Postdam University, Germany).
• Protein Energies and Dynamics through Molecular Simulations (January 2010)
Universidad de Concepción (Concepción, Chile)
Profesor: Jordi Villá, PhD (Spain).
• Advanced course in free energy calculation: practice and theory (December 2008)
Center for Bioinformatics and Molecular Simulation, Universidad de Talca (Talca, Chile)
Professor: Christophe Chipot, PhD (Universitè Henri Poincarè, France).
• Implementation, visualization and analysis of molecular dynamics simulations (December 2008)
Center for Bioinformatics and Molecular Simulation, Universidad de Talca (Talca, Chile)
Professor: Marcos Sotomayor, PhD (Harvard University, USA).
• Molecular dynamics simulations (December 2007)
Center for Bioinformatics and Molecular Simulation, Universidad de Talca (Talca, Chile)
Professor: Chris Chipot, PhD (Christophe Chipot, PhD (Universitè Henri Poincarè, France).
International Meetings
• External Architecture of the Large-Conductance Ca2+ and Voltage-Activated K+ (BKCa) Revealed by a Spectroscopic Ruler. JP Castillo, JE Sanchez-Rodriguez, HC Hyde, C Zalezer, D Aguayo. Biophysical Journal 104, 367.
• Insights into the Ion Permeation Process of High and Low Conductance K-Channels using Non-Equilibrium Molecular Dynamics.FD Gonzalez-Nilo, R Sepulveda, D Naranjo, D Aguayo, I Araya, I Varas, Biophysical Journal 106 (2), 539a .2014.
• Substitutions at F380 in S6 by Small Hydrophobic Amino Acids Makes the Opening Transition in BK Channels Rate Limiting. W Carrasquel-Ursulaez, GF Contreras, R Sepúlveda, D Aguayo, Biophysical Journal 106 (2), 437a.
• Molecular Dynamics Simulatiosn of Current’-Voltage in BK and Shaker K Channels. Sepulveda R, Marquez V. Aguayo D. Arya I, Gonzalez-Nilo.XII PABMB CONGRESS. Puerto Varas
• Insights into the role of Pro475 in yhe ion permeation process of Shaker K-Channel using non-equilibrium molecular dynamics. Sepulveda R, Aguayo D. Arya I, Gonzalez-Nilo.XII PABMB CONGRESS. Puerto Varas.
• Understanding the conductance of shaker potassium channel using non-equilibrium molecular dynamics. Sepúlveda R.V.1; Márquez, V; Aguayo, D Naranjo, D; Gonzalez- Nilo, F.D.. Sao Pablo School of advance science.
• Structural characterization of soft nanobiomaterials at the single particle level by high throughput / high contrast (low voltage) electron microscopy. Daniel V. Aguayo, Hegaly Mendoza-Vilches, Fernando D. Gonzalez-Nilo, Luis E. Dettin, Jose R. Casas-Finet, Mark A. Schenerman, Eugene Paransky and Raúl E. Cachau
• pH dependence of conformational changes of PAMAM using a single site and outer shell titration coordinate models. Daniel R. Aguayo, Paz V.Tapia, Raúl E. Cachau and Fernando D. Gonzalez-Nilo.
• Sociedad Iberoamericana de Bioinformática (SoIBio) September 26-28, 2010, Gran Hotel Termas de Chillan, Chile Nano-carriers design to transport drugs through generation of internal cavities. L. Monsalve, C. Sandoval, D. Aguayo, R. Cachau, F. Gonzalez-Nilo.
• Biophysical Meeting 2010. A molecular model for the BKCa channel and the location of b1 in the b1/a subunit complex Zaelzer C., Hyde C., Aguayo D, Vergara A., Poblete H., Sandtner W., Gonzalez-Nilo F., Bezanilla F. and Latorre R. Biophysical Journal Volume 98, Issue 3, Supplement 1, January 2010, Pages 127a-128a
• I Nanoestructures summer School. Escuela de Nanoestructuras. Universidad Técnica Federíco Santa María. Valparaíso, Chile. 12 al 15 de Junio 2010. Estudio estructural del proceso de captura de drogas dependiente del pH en el dendrímero PAMAM G4.
• 5th annual RIB (Red Iberoamericana de Bioinformática) conference. Nanoinformatics: Dendrimer-Drug Interaction Energy. Ávila, F., González-Nilo, F, Caballero, J., Aguayo, D.. Oct. 15-17, 2008. Pontificia Universidad Catolica de Chile, Santiago, Chile.
• VI Workshop of molecular of computational chemistry and molecular spectroscopy. Octubre 21-24, 2008. Study Of The Interaction Between Progesterone And ?- Cyclodextrin By Steered Molecular Dynamics. J. Caballero, D. Aguayo, F. D. González- Nilo, C. Zamora and C. Yañez
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1st Place. Feria Científica Nacional Juvenil
Academia Chilena de Ciencias
Chile, 1993
Award to the 1st. place.
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Honours Feria Científica Nacional Juvenil
Academia Chilena de Ciencias
Chile, 1994
Honours Feria Científica Nacional Juvenil.
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1st Place Feria Científica Nacional Juvenil
Academia Chilena de Ciencias
Chile, 1995
Award to the 1st. place.
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Best Thesis in Microbiology
Universidad Andrés Bello
Chile, 2008
Biochemistry School.
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Doctoral Scholarship
Universidad de Talca
Chile, 2012
Scholarship.
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Financial Aid for International Travel
Universidad de Talca
Chile, 2010
Financiamiento de viaje al extranjero.
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Biological Science Alumni
Universidad Andrés Bello
Chile, 2016
Best student to date.
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Know-hub Ignition Program
UCRiverside-KnowHub
Chile, 2020
programa dirigido a investigadores, estudiantes de pre y posgrado y emprendedores. El objetivo de este programa es identificar equipos con alto potencial emprendedor, apoyando la concepción de una propuesta de valor, la validación y el escalamiento de su producto o servicio. De esta manera, Know Hub Ignition busca apoyar la formación y maduración de emprendimientos de base tecnológica para promover la innovación en Chile mediante la transferencia de resultados de investigación para el beneficio de la sociedad.
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Innovation and Arts Outstanding research
UNIVERSIDAD ANDRES BELLO
Chile
Award ” from Vice-rectory of Academic affairs, Universidad Andres Bello. for Covid2019 initiative and other innovations
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Innovation and Arts Outstanding research
UNIVERSIDAD ANDRES BELLO
Chile, 2020
Innovation and Arts Outstanding research.
Tecnología de Nanoburbujas para sistema de control de polvo expulsado por tronaduras |
"AgroIA: Innovación basada en visión computacional y Deep-Learning para el sector productor de uva de mesa y vino. Diseño, desarrollo y aplicación de un sistema autónomo de predicción de rendimiento |
Evaluación de mecanismos de resistencia presente en microorganismos que prosperan en ambientes naturales con Arsénico: caso del género Exiguobacterium en el Salar del Huasco” |
Role of the Lipopolysaccharide core oligosaccharide structure on the Lipopolysaccharide layer thermotropic phase behavior and its relation to the AMP antimicrobial activit |
THEORETICAL AND EXPERIMENTAL IDENTIFICATION OF NOVEL CHEMICAL COMPOUNDS TARGETING THE LIPOPOLYSACCHARIDE (LPS) OF CLINICALLY RELEVANT BACTERIAL PATHOGENS |
Desarrollo de una vacuna frente a VIH=> Estudio de los cambios en la biología de células dendríticas humanas tras interacción con distintos sistemas de liberación de péptidos de VIH (VIHVACD) |
“Development of a vaccine against HIV: study of changes in the biology of human dendritic cells after interaction with different HIV peptide delivery system.” |
“Microcalorimetry Platform for thermodynamic characterization of Biological binding processes” |
“Theoretical And Experimental Identification Of Novel Chemical Compounds Targeting The Lipopolysaccharide (Lps) Of Clinically Relevant Bacterial Pathogens” |
Plataforma de microcalorimetría de Titulación Isotérmica para caracterización termodinámica de procesos de reconocimiento molecular en sistemas Biológicos y químicos |
Combined theoretical and experimental investigation of the structural role of antimicrobial peptides on the destabilization of lipopolysaccharide regions of the bacterial outer membrane |
Study of structural and dinamic propierties that govern selectivity and conductance of K channels under non equilibrium conditions |
“Combined theoretical and experimental investigation of the structural role of antimicrobial peptides on the destabilization of lipopolysaccharide regions of the bacterial outer membrane”. |
Instituto Milenio Centro Interdisciplinario De Neurociencia De Valparaiso |
“Study of structural and dynamic properties that govern selectivity and conductance of K channels under non equilibrium conditions”. |
HORMONAL REGULATION DURING RIPENING IN THE CHILEAN STRAWBERRY FRUIT=> A DEEPER VIEW INSIGHT THE MOLECULAR EVENTS |
ESTUDIO ELECTROQUIMICO DE FARMACOS ESTEROIDALES=> INTERACCION CON CICLODEXTRINAS EN SOLUCION E INMOVILIZADAS SOBRE UN ELECTRODO |
International Cooperative Action on Grid Computing and Nano-Bio-Medical Informatics between the European Union, Latin America and the Western Balkans. ACTION-Grid. |
“Role of the Lipopolysaccharide core oligosaccharide structure on the Lipopolysaccharide layer thermotropic phase behavior and its relation to the AMP antimicrobial activity” |

Daniel Aguayo
Assistant Professor
Molecular Biophysics & Bioinformatics Group
UNIVERSIDAD ANDRES BELLO
Santiago, Chile

Fernando Gonzalez
Titular Professor
Facultad de Ciencias de la Vida
Universidad Andres Bello
Santiago, Chile

Claudia Saavedra
Full Professor
Departmento de Ciencias de la Vida
UNIVERSIDAD ANDRÉS BELLO
Santiago, Chile

Romina Sepúlveda
Profesor Investigador
Facultad de Ciencias Biológicas
Universidad Andrés Bello
Santiago, Chile

IVAN CALDERON
Associate Professor / Principal Investigator/ Master in Biotechnology & Life Sciences Director
Biological Sciences
UNIVERSIDAD ANDRÉS BELLO
SANTIAGO, Chile

Roberto Luraschi
Asistente de investigación
Departamento de biología
Universidad de Santiago de Chile
Santiago, Chile

FRANCISCO REMONSELLEZ
Professor
Ingenieria Química
UNIVERSIDAD CATÓLICA DEL NORTE
Antofagasta, Chile

Melissa Alegría
Académico Asociado
Facultad de Ingeniería y Negocios
Universidad de Las Américas
Santiago, Chile

Leda Guzman
Profesor Adjunto
Instituto de Química
Pontificia Universidad Católica de Valparaíso
Valparaíso, Chile

Paula Solar
Directora de Investigación y Posgrado
Dirección de Investigación y Posgrado
Universidad SEK
Santiago, Chile

Bárbara Fuentes
Acádemcia, Investigadora, Jefe de Carrera
Departamento de Ingeniería Química
UNIVERSIDAD CATÓLICA DEL NORTE
Antofagasta, Chile

EVA BUSTAMANTE
JEFE DE COORDINACION CIENTIFICA
INVESTIGACION Y DOCENCIA
FUNDACION ARTURO LOPEZ PEREZ
Santiago, Chile

Nicolas Pacheco
PROFESOR ADJUNTO
CIENCIAS BIOLOGICAS
Universidad Andrés Bello
Santiago centro, Chile

VANESSA MARABOLI
Ingeniera Bioinformática
Facultad de Ciencias de la Vida
Universidad Andrés Bello
Santiago, Chile