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Raquel Clara Quatrini Nyqvist

Research Associate

Fundación Ciencia & Vida

Santiago, Chile

Líneas de Investigación


Microbiology of Acidic Biomes; Population and Community Genomics; Ecophysiology of Extremophiles; Mineral Processing Biotechnologies

Educación

  •  Microbiología, UNIVERSIDAD DE CHILE. Chile, 2004
  •  Biology, Universidad Nacional del Comahue. Argentina, 1998

Experiencia Académica

  •   Research Associate Full Time

    Fundación Ciencia & Vida

    -

    Santiago, Chile

    2007 - A la fecha

  •   Postdoctoral Researcher Full Time

    Fundación Ciencia & Vida

    -

    Santiago, Chile

    2004 - 2007

Experiencia Profesional

  •   Research Associate Full Time

    Fundación Ciencia & Vida

    Santiago, Chile

    2004 - A la fecha

  •   Faculty Comitee, PhD programm in Biotechnology, Part Time

    Universidad Andres Bello

    Santiago, Chile

    2014 - 2019

  •   Faculty Comitee, PhD Programm in Molecular Biosciences Part Time

    Universidad Andres Bello

    Santiago, Chile

    2010 - 2014

  •   Study Group Member Other

    Fondecyt

    Santiago, Chile

    2011 - 2013

  •   Study Group Director Other

    Fondecyt

    Santiago, Chile

    2013 - 2014

  •   Profesor Part Time

    Universidad San Sebastián

    Santiago, Chile

    2019 - A la fecha

Formación de Capital Humano


Thesis direction:

* Francisco Luciano Issotta Contardo. Estudio eco-evolutivo de comunidades extremófilas inherentes al gradiente ambiental de un sistema hídrico acídico de origen volcánico en el Norte de Patagonia. Doctorado en Biotecnología, Universidad Nacional Andrés Bello. In progress, Septiembre 2017 –to date.

* Ana Rosa Moya Beltrán. Caracterización del pangenoma de los Acidithiobacillus: contribución del complemento génico esencial y accesorio a la diversificación y evolución del taxón. Doctorado en Biotecnología, Universidad Nacional Andrés Bello. Completeted, 2020.

* Paulo Cesar Covarrubias Pizarro. Tipificación y caracterización genómica y morfológica de virus microbianos presentes en econichos de biolixiviación. Doctorado en Biociencias Moleculares, Universidad Andrés Bello. Completed, 2019.

* Rodrigo Andrés Flores Ríos. Caracterización del sistema TRA de Acidithiobacillus ferrooxidans ATCC 23270 y su papel en la transferencia conjugativa del ICEAfe1. Doctorado en Microbiología, Universidad de Santiago de Chile. Completed, 2018.

* Juan Pablo Cárdenas Astudillo. Estudio genómico-comparativo de la respuesta a estrés oxidativo en microorganismos acidófilos: modelos de función, regulación y evolución. Doctorado en Biotecnología, Universidad Andrés Bello. Completed, 2015.

* Mauricio Arenas. Estudio de las propiedades estructurales del regulador transcripcional FUR de Acidithiobacillus ferrooxidans. Doctorado en Biotecnología, Universidad Nacional Andrés Bello. Completed, 2014.

* Lillian Acuña. Caracterización del Sistema de Inmunidad CRISPR/Cas en Acidithiobacillus caldus. Doctorado en Ciencias Biomédicas, Universidad Andrés Bello. Completed, 2013.

- Masters Thesis:

* Stefano Bueno Rossoni. Caracterización del vesículas secretorias de bacterias del género Acidithiobacillus. Magíster en Biotecnología, Universidad Nacional Andrés Bello. Completed, 2020.

* Cesar Manuel Valenzuela Alegría. Caracterización del plasmidoma de bacterias del género Acidithiobacillus. Magíster en Biotecnología, Universidad Nacional Andrés Bello. Completed, 2020.

* Karina Cordero Fernández. Análisis transcriptómico en un modelo de agregación de la proteína TDP-43. Magíster en Biotecnología, Universidad Nacional Andrés Bello. Completed, 2020. Co-tutor.

* Victor Andrés Alegría Mera. Papel del regulador transcripcional Saci1223 sobre la expresión de genes asociados a procesos de producción y conversión de energía en la arquea termoacidófila Sulfolobus acidocaldarius durante la formación de biopelículas. Magíster en Biotecnología, Universidad Nacional Andrés Bello. Completed, 2017. Co-tutor.

* Cristian Silva Fernandez. Mecanismos de inmunidad adquirida en Acidithiobacilli. Magíster en Biotecnología, Universidad Nacional Andrés Bello. Completed, 2011.

* Cristopher Andrés Oporto Alarcón. Estudio de métricas para clustering en redes de asociación funcional de proteínas para genomas microbianos. Magíster en Ingeniería Civil Informática, Universidad de Santago de Chile. Completed, 2009.

- Undergraduate Thesis:

* Abraham Isaac Zapata Araya. Análisis de la diversidad viral asociada a comunidades microbianas extremófilas hidrotermales del complejo volcánico Copahue usando estrategias metagenómicas. Pregrado en Bioquímica, Universidad San Sebastián. Agosto 2020 - to date.

* Ivette Natalia Olave Orellana. Estudio de cepas acidófilas mesotermófilas tipo Acidithiobacillus caldus aisladas del sistema geotermal acídico Copahue-Caviahue y su tolerancia a iones cloruro. Ingeniería en Biotecnología, Universidad Mayor. Completed, 2019.

* Yazna Tapia Cisternas. Estudio de los mecanismos de resistencia a cadmio en el genero Acidithiobacillus y propuesta de diseño de vector plasmidial potencialmente útil en la construcción de biosensores de cadmio aplicables a la minería. Ingeniería Civil en Biotecnología, Universidad San Sebastián. Completed, 2018.

* Rodolfo Alfredo Gomez Salinas. Contribución del complemento génico flexible al fitness biologico y la competitividad de bacterias del linaje 3 del genero Acidithiobacillus. Ingeniería Civil en Biotecnología, Universidad San Sebastián. Completed, 2018.

* Fernanda Sazo Pradenas. Análisis de la diversidad genómica a nivel intra-específico de bacteria acidófila y principal modelo en biominería, Acidithiobacillus ferrooxidans. Ingeniería en Biotecnología, Universidad Tecnológica Metropolitana. Frozen.
* María Ignacia von Unger. Estudio de los elementos integrativos conjugativos tipo 2 presentes en distintas cepas de Acidithiobacillus caldus, y su contribución a la formación de biopeliculas, desde una perspectiva transcripcional. Ingeniería en Biotecnología, Universidad Andrés Bello. Completed, 2016.

* María Isabel Yanquepe. Desarrollo de un pipeline integrativo para la identificación de elementos genéticos móviles en genomas microbianos. Ingeniería en Bioinformática, Universidad de Talca. Completed, September 2014.

* Francisco Luciano Issotta Contardo. Benchmarking de los métodos vigentes de asignación taxonómica y ensamblado de secuencias cortas utilizando metagenomas microbianos y virales sintéticos. Ingeniería en Bioinformática, Universidad de Talca. Completed, 2014.

* Ana Rosa Moya Beltrán. Análisis comparativo de metagenomas microbianos de ecosistemas acídicos y exploración del potencial metabólico común y diferencial. Ingeniería en Bioinformática, Universidad de Talca. Completed, 2014.

* Alfredo Hernán Monsalve Bustos. Análisis ecofisiológico del pangenoma de bacterias de biolixiviación del género Sulfobacillus spp. Pregrado en Ingeniería en Biotecnología, Universidad de Santiago de Chile. Completed, 2013.

* Pablo Tapia Salinas. Identificación y caracterización de un profago presente en el genoma de Acidithiobacillus caldus ATCC 51756. Pregrado en Bioquímica, Pontifícia Universidad Católica de Valparaíso. Completed, 2012

* Juan José Haristoy Lagos. Análisis genómico y funcional de plasmidos cripticos presentes en el genoma de Acidithiobacillus caldus ATCC 51756. Pregrado en Bioquímica, Pontifícia Universidad Católica de Chile. Completed, 2012

* David Loyola. Determinación de cambios en el perfil transcripcional de Escherichia coli expuesta a telurito/cefotaxima utilizando microarreglos de DNA. Pregrado en Ingeniería en Bioinformática, Universidad de Talca. October 2011. Co-advisor.

* Pamela Nieto Pacheco. La unión Fur:DNA in vivo y el efecto de su regulación transcripcional en Acidithiobacillus ferrooxidans. Pregrado en Bioquímica, Universidad de Chile. Completed, 2009. Co-advisor.

* Jorge Herrera. Unión de grupo hemo al regulador Fur de Acidithiobacillus ferrooxidans. Pregrado en Bioquímica, Universidad Católica de Chile. Completed, 2007. Co-advisor.

Teaching:

Doctorate Training:
- Programable nucleases and genome editing Class, Biotecnología: Aplicaciones y oportunidades de Negocio en Chile y el Mundo Course (BIO 511), PhD. Program in Biotechnology, Universidad Nacional Andrés Bello. Guest lecturer
- Transcriptomics Class, Bioinformatics and Genome Biology Course (BIO 502) course, PhD. Program in Biotechnology, Universidad Nacional Andrés Bello. Guest lecturer

Undergraduate Training:
- Molecular Microbiology (BIOQ1046), Undergraduate Program in Biochemistry, Universidad San Sebastián. Responsible.
- Introduction to transcriptomics Class, Genetic Engineering and Biotechnology Course (BIT 230), Undergraduate Program in Biomedical Sciences, Universidad Nacional Andrés Bello . Guest lecturer
- Metabolic Reconstruction Class, Biotechnology of enzymes and metabolic pathways Course, Undergraduate Program in Biotechnology, Universidad de Chile. Guest lecturer


Difusión y Transferencia


2020 October-to date.
Microalucinante, TV capsules.
Animated series for school children produced by Pablo Rosenblatt, to be broadcasted during 2021. Production stage.
Funding: ANID ICM NCN17_093; Fondecyt 1181251

2020 May
Campo de géiseres El Tatio, el laboratorio geotérmico más alto del mundo para conocer virus.
Brief interview by Lorenzo Palma, Ciencia en Chile, on the scientific activities taking place under the context of
Fondecyt project 1190998.
Available at: https://www.cienciaenchile.cl/campo-de-geiseres-el-tatio-el-laboratorio-geotermico-mas-alto-delmundo-
para-conocer-virus/

2018 July
Participant in the Exploradores: del átomo al cosmos, TV capsules.
Brief interview on the scientific activities of the Microbial Ecophysiology Lab. Produced by Pablo Rosenblatt to be broadcasted by TVN´s Canal 24 Horas during the 2nd semester of 2018.

2018 January
Scientific advisor in the ongoing production of “LocosLab”.
Animated series for school children produced by DinoGorila (www.dinogorila.com) on diverse contingent scientific topics, including the revolutionary genomic edition tool, CRISPR/Cas9.

2016 August
Participant in the Ciencia para Todos, TV capsules.
Brief interview on the scientific activities of the Microbial Ecophysiology Lab. Produced by Pablo Rosenblatt and broadcasted by TVN´s Canal 24 Horas during the 1st semester of 2017. Available at: https://www.youtube.com/watch?v=XfC6LlQTrWo&feature=youtu.be

2014 September
Scientific advisor in the production of Píldoras Científicas “Ursi y Magnogeek, Exploradores de Otro Mundo”, Temporada 2.
Six aimed videos for school-aged children were developed by Fundación Ciencia & Vida and Imago Productions as part of a series about microbial extremophiles and earth sciences.
These videos were sponsored by Explora Conicyt and the Consejo Nacional de Televisión (CNTV) and are publicly available at Novasur.
www.novasur.cl/videos/el-inicio-del-viaje
www.novasur.cl/videos/avalancha
www.novasur.cl/videos/sofocante-aventura
www.novasur.cl/videos/congeladamente-vivos
www.novasur.cl/videos/profusas-profundidades
www.novasur.cl/videos/perdidos-por-accidente
Author: Ulisse-Luz C
Creator: Rosemblat-Bono I
Science advisors: Quatrini R; Herve Allamand F
Funding: EPA20036


Premios y Distinciones

  •   Scholarship for undergraduate training

    Universidad Nacional del Comahue

    Argentina, 1996

    Scholarship for undergraduate training in Biology at the C.R.U.B, Universidad Nacional del Comahue.

  •   Fellowship for postgraduate technical and scientific training

    Science and Technology Fellowship

    Chile, 1998

    Science and Technology Fellowship for postgraduate technical and scientific training at the Instituto Nacional de Parasitología Mario Fatala Chabén (ANLIS). Buenos Aires, Argentina.

  •   Scholarship for postgraduate training

    UNIVERSIDAD DE CHILE

    Chile, 1999

    German Academic Exchange Service (DAAD) scholarship to achieve the University Degree of Doctor in Microbiology. Faculty of Sciences, Universidad de Chile. Santiago, Chile.

  •   Fellowship for technical training

    Sydney Kimmel Cancer Center

    Estados Unidos, 2004

    Antorchas-American Society for Microbiology (ASM) Fellowship for technical training in microarray technology. Sydney Kimmel Cancer Center. San Diego, California.

  •   Best Incorporation Presentation -SoMiCh 2006

    Sociedad Chilena de Microbiología

    Chile, 2006

    Award to the best Incorporation Presentation to become member of the Chilean Microbiology Society. XVIII Congreso Latinoamericano de Microbiología, Pucón, Chile.

  •   Fellowship for technical training

    European Molecular Biology Organization

    Brasil, 2007

    European Molecular Biology Organization (EMBO) Fellowship for technical training in Comparative Genomics. Rio de Janeiro, Brasil.

  •   Best poster award - IBS 2007

    International Biohydrometallurgy Symposium 2007

    Alemania, 2007

    Award to the best poster at the 17th International Biohydrometallurgy Symposium - IBS 2007. Frankfurt, Germany.

  •   Best poster award

    International Biohydrometallurgy Symposium - IBS 2009

    Argentina, 2009

    Award to the best poster at the 18th International Biohydrometallurgy Symposium - IBS 2009. Bariloche, Argentina.

  •   Honorary mention poster award

    International Biohydrometallurgy Symposium - IBS 2011

    China, 2011

    Award poster honorary mention at the 19th International Biohydrometallurgy Simposium - IBS 2011. Changsha, China.


 

Article (63)

The Flexible Genome of Acidophilic Prokaryotes
Acidiferrimicrobium australe gen. nov., sp. nov., an acidophilic and obligately heterotrophic, member of the Actinobacteria that catalyses dissimilatory oxido-reduction of iron isolated from metal-rich acidic water in Chile
Acidithiobacillus ferrianus sp. nov.: an ancestral extremely acidophilic and facultatively anaerobic chemolithoautotroph
Acidophile microbiology in space and time
JMJD1B, a novel player in histone H3 and H4 processing to ensure genome stability
Acidithiobacillus ferrooxidans
Acidithiobacillus sulfuriphilus sp. nov.: an extremely acidophilic sulfur-oxidizing chemolithotroph isolated from a neutral pH environment
Domestication of Local Microbial Consortia for Efficient Recovery of Gold Through Top-Down Selection in Airlift Bioreactors
Nucleotide Second Messenger-Based Signaling in Extreme Acidophiles of the Acidithiobacillus Species Complex: Partition Between the Core and Variable Gene Complements
The Type IV Secretion System of ICEAfe1: Formation of a Conjugative Pilus in Acidithiobacillus ferrooxidans
A DNA segment encoding the anticodon stem/loop of tRNA determines the specific recombination of integrative-conjugative elements in Acidithiobacillus species
Insights into the biology of acidophilic members of the Acidiferrobacteraceae family derived from comparative genomic analyses
Microbiomes in extremely acidic environments: functionalities and interactions that allow survival and growth of prokaryotes at low pH
Occurrence, integrity and functionality of AcaML1-like viruses infecting extreme acidophiles of the Acidithiobacillus species complex
16S rRNA and Multilocus Phylogenetic Analysis of the Iron Oxidizing Acidophiles of the Acidiferrobacteraceae Family
Are there Viruses in Industrial Bioleaching Econiches?
Comparative Genomics Analysis of a New Exiguobacterium Strain from Salar de Huasco Reveals a Repertoire of Stress-Related Genes and Arsenic Resistance
Draft genome sequence of Acidithiobacillus thiooxidans CLST isolated from the acidic hypersaline Gorbea salt flat in northern Chile
Draft genome sequence of the type strain of the sulfur-oxidizing acidophile, Acidithiobacillus albertensis (DSM 14366)
Genetic Basis of Metal Resistance in Acidiphilium sp. DSM 27270 (Yenapatur)
Metagenome-Derived Draft Genome Sequence of Acidithiobacillus ferrooxidans RV1 from an Abandoned Gold Tailing in Neuquén, Argentina
Molecular Systematics of the Genus Acidithiobacillus: Insights into the Phylogenetic Structure and Diversification of the Taxon
Mutantelec: An In Silico Mutation Simulation Platform for Comparative Electrostatic Potential Profiling of Proteins
Type IV Secretion Systems Diversity in the Acidithiobacillus Genus
Aerobic Lineage of the Oxidative Stress Response Protein Rubrerythrin Emerged in an Ancient Microaerobic, (Hyper)Thermophilic Environment
Detection, identification and typing of Acidithiobacillus species and strains: a review
Draft genome sequence of chloride-tolerant Leptospirillum ferriphilum Sp-Cl from industrial bioleaching operations in northern Chile
Genomic and metagenomic challenges and opportunities for bioleaching: a mini-review
AFAL: a web service for profiling amino acids surrounding ligands in proteins
Draft Genome Sequence of the Iron-Oxidizing, Acidophilic, and Halotolerant "Thiobacillus prosperus" Type Strain DSM 5130
Draft Genome Sequence of the Nominated Type Strain of "Ferrovum myxofaciens," an Acidophilic, Iron-Oxidizing Betaproteobacterium.
Genetic variability of psychrotolerant Acidithiobacillus ferrivorans revealed by (meta)genomic analysis
Multi Locus Sequence Typing scheme for Acidithiobacillus caldus strain evaluation and differentiation
Analysis of gene expression in response to copper stress in Acidithiobacillus ferrooxidans strain D2, isolated from a copper bioleaching operation.
Architecture and Gene Repertoire of the Flexible Genome of the Extreme Acidophile Acidithiobacillus caldus
DNA, Cell Wall and General Oxidative Damage Underlie the Tellurite/Cefotaxime Synergistic Effect in Escherichia coli
Temporal dynamics of genes involved in metabolic pathways of C and N of L. ferriphilum, in the industrial bioleaching process of Escondida mine, Chile.
Comparative genomics of the oxidative stress response in bioleaching microorganisms
Complete Genome Sequence of Temperate Bacteriophage AcaML1 from the Extreme Acidophile Acidithiobacillus caldus ATCC 51756
ICEAfe1, an Actively Excising Genetic Element from the Biomining Bacterium Acidithiobacillus ferrooxidans
Thiol/Disulfide System Plays a Crucial Role in Redox Protection in the Acidophilic Iron-Oxidizing Bacterium Leptospirillum ferriphilum
Draft Genome Sequence of the Extremely Acidophilic Biomining Bacterium Acidithiobacillus thiooxidans ATCC 19377 Provides Insights into the Evolution of the Acidithiobacillus Genus
Comparative genomics begins to unravel the ecophysiology of bioleaching
A 300 kpb genome segment, including a complete set of tRNA genes, is dispensable for Acidithiobacillus ferrooxidans
Comparative genomics begins to unravel the ecophysiology of bioleaching.
Draft Genome Sequence of the Extremely Acidophilic Bacterium Acidithiobacillus caldus ATCC 51756 Reveals Metabolic Versatility in the Genus Acidithiobacillus
Extending the models for iron and sulfur oxidation in the extreme Acidophile Acidithiobacillus ferrooxidans
Predicted CO/CO2 fixation in Ferroplasma spp. via a novel chimaeric pathway.
Regulation of expression of the PetI operon involved in iron oxidation in the biomining bacterium Acidithiobacillus ferrooxidans.
Selection and evaluation of reference genes for improved interrogation of microbial transcriptomes: case study with the extremophile Acidithiobacillus ferrooxidans
Acidithiobacillus ferrooxidans metabolism: from genome sequence to industrial applications.
Comparative genome analysis of Acidithiobacillus ferrooxidans, A. thiooxidans and A. caldus: Insights into their metabolism and ecophysiology
Iron homeostasis strategies in acidophilic iron oxidizers: Studies in Acidithiobacillus and Leptospirillum
Microbial iron management mechanisms in extremely acidic environments: comparative genomics evidence for diversity and versatility
Bioinformatic prediction and experimental verification of Fur-regulated genes in the extreme acidophile Acidithiobacillus ferrooxidans
Insights into the metabolism and ecophysiology of three acidithiobacilli by comparative genome analysis.
Iron homeostasis strategies in acidophilic iron oxidizers: Comparative genomic analyses
Insights into the iron and sulfur energetic metabolism of Acidithiobacillus ferrooxidans by microarray transcriptome profiling
Microarray and bioinformatic analyses suggest models for carbon metabolism in the autotroph Acidithiobacillus ferrooxidans
Genomic insights into the iron uptake mechanisms of the biomining microorganism Acidithiobacillus ferrooxidans
The ferric iron uptake regulator (Fur) from the extreme acidophile Acidithiobacillus ferrooxidans
Aspects of the predicted physiology of Acidithiobacillus ferrooxidans deduced from an analysis of its partial genome sequence
Variación morfológica y dieta en dos poblaciones de Liolaemus elongatus Koslowsky, 1896 (Iguania: Tropiduridae) del noroeste patagónico

BookSection (4)

Acidophile Microbiology in Space and Time.
Progress in Acidophile Genomics.
The Flexible Genome of Acidophilic Prokaryotes.
The Use of Bioinformatics and Genome Biology to Advance Our Understanding of Bioleaching Microorganisms

BookWhole (2)

Acidophiles: Life in Extremely Acidic Environments.
Integration of Scientific and Industrial Knowledge on Biohydrometallurgy.

ConferencePaper (4)

Analysis of gene expression in response to copper stress in Acidithiobacillus ferrooxidans strain D2, isolated from a copper bioleaching operation
Temporal dynamics of genes involved in metabolic pathways of C and N of L. ferriphilum, in the industrial bioleaching process of Escondida mine, Chile
Predicted CO/CO(2) fixation in Ferroplasma spp. via a novel chimaeric pathway
Insights into the metabolism and ecophysiology of three acidithiobacilli by comparative genome analysis

ConferencePoster (59)

A pan-chromosome view of iron-oxidizing Acidithiobacillus species.
Antimicrobial resistance and persistence determinants in revised linages of the human gut commensal Faecalibacterium prausnitzii.
Benchmarking of taxonomy assignment methods for metagenomic analysis using acidic microbiomes as test case.
Caracterización de vesículas de membrana en bacterias acidófilas del género Acidithiobacillus.
Evaluación de perfil taxonómico y funcional de consorcios autótrofos y heterótrofos arsénico-tolerantes recuperados de Salto del Agrio (Neuquén, Argentina).
Expanding and exploring the catalogued diversity of Acidithiobacillia class acidophiles from novel niches.
Genomic and physiologic characterization of new mixotrophic arsenic oxidizing Ancylobacter isolated from high Andean sediments near Tacora volcano.
Integrative Conjugative Elements of the ICE.2 Family contribute to genetic plasticity in the Class Acidithiobacillia.
Novel configurations of Type IV CRISPR-Cas system emerging from the Acidithiobacillus species complex as a study model.
Reconstrucción, identificación y comparación de elementos genéticos móviles episomales e integrativos del complejo específico Acidithiobacillus.
Rio Agrio, microdiversidad de Acidithiobacillusa través de un gradiente natural de acidez extrema.
Río Agrio: microbial diversity across an extreme environmental gradient.
Vesiculation is a common phenomenon in extreme acidophilic bioleaching bacteria of the Acidithiobacillus genus.
A polyphasic and genomic evaluation of Acidithiobacillus thiooxidans strain diversity uncovers cryptic lineages.
Análisis de la microdiversidad de poblaciones de Acidithiobacillus a lo largo de un gradiente natural de acidéz extrema.
Análisis metagenómico de un consorcio arsénico-tolerante dominado por Acidithiobacillus spp. recuperado del Rio Agrio (Neuquén, Argentina).
Benchmarking of taxonomy assignment methods for metagenomic analysis using acidic microbiomes as test case.
Biofilm formation in Acidiferrobacter murciensis SPIII/3 : a bioinformatics and epifluorescence microscopy study.
Caracterización del Pangenoma de los acidithiobacilli: aspectos diferenciales entre sublinajes de bacterias hierro oxidantes.
Estudio de la diversidad de plasmidios del complejo específico Acidithiobacillus.
Re-evaluation of the Acidithiobacillus species complex based on genomic analysis.
Señalización mediante segundos mensajeros nucleotídicos en la clase bacteriana Acidithiobacillia.
The Acidithiobacilli, genomics and evolution of the taxon.
Variabilidad genética del sistema flagelar y sus implicancias en el fenotipo mótil de bacterias biolixiviantes del género Acidithiobacillus.
16S rRNA and multilocus phylogenetic analysis of the iron oxidizing acidophiles of the Acidiferrobacteraceae family.
Emerging insights into the type IV CRISPR/Cas systems from genomic analyses in the Acidithiobacillus species complex.
Genetic basis of metal resistance in Acidiphilium sp. DSM 27270 (Yenapatur).
Genome analysis of species of the new bioleaching acidophilic bacterial genus Acidiferrobacter.
Mapping Acidithiobacillus populations with high resolution onto a natural environmental gradient.
Metagenome-derived draft genome sequence of Acidithiobacillus ferrooxidans RV1 from an abandoned gold tailing in Neuquén,
Molecular systematics of the genus Acidithiobacillus: insights into the phylogenetic structure and diversification of the taxon.
Phylogenomic-based species delimitation within the genus Acidithiobacillus.
Transcriptomic analysis by RNA-Seq in a TDP-43 aggregation model.
Type IV secretion systems diversity in the Acidithiobacillus genus.
Type IV secretion systems in Integrative Conjugative Elements of the genus Acidithiobacillus.
¿Are there viruses in industrial bioleaching econiches?.
Functional evaluation of proteins involved in metabolism and transduction of c-di-GMP coded in the integrative conjugative element ICEAcaTY.2 of Acidithiobacillus caldus.
Genetic traits associated with distribution of prophages in acidophilic genomes.
Microdiversity of Acidithiobacillus populations recovered from an abandoned tailing in the gold mining district of Andacóllo (Neuquén, Argentina).
Temporal profiling of the microbial community from the lime-treated abandoned mine tailing “Relave Viejo” in Neuquén, Argentina.
C-di-GMP control modules confined within mobile elements: the case of ICEAcaTY.2.
Comparative Analyses of Metagenomes from Acid Mine Drainages.
Genomic taxonomy of the Acidithiobacilli.
Targeted metagenomic analysis of Mynydd Parys Acid Mine Drainage microbial communities.
The Integrative and Conjugative Element ICEAcaTY.2 and its contribution to adhesion and biofilm development.
A Next Generation Multilocus Sequence Typing Scheme for Acidithiobacillus species.
Análisis comparativo de los sistemas CRISPR-Cas presentes en Elementos Conjugativos Integrativos tipo 2 en bacterias del género Acidithiobacillus.
Benchmarking available methods for prediction of Mobile Genetic Elements in complete genomes.
Benchmarking of binning methods using a conceptual metagenome.
Bioinformatic analysis of the incidence of lysogeny in acidophilic genomes and metagenomes.
c-di-GMP pathway modules in the flexible genome of the Acidithiobacilli.
Caracterización del T4SS presente en el ICEAfe1, un elemento genético móvil de la bacteria acidófila Acidithiobacillus ferrooxidans.
Characterization of a T4SS from ICEAfe1, a mobile genetic element from the acidophilic bacterium Acidithiobacillus ferrooxidans.
Comparative analysis of metagenomes from Extremely acidic environments using a phylogenetic approach.
Comprehensive Characterization of the Pangenome of Acidithiobacillus caldus.
Functional analysis of the recombination module from ICEAfe1, a mobile genetic element from the acidophilic bacterium Acidithiobacillus ferrooxidans.
Multi Locus Sequence Typing-based characterization of the intraspecific variability of sulfur oxidizing Acidithiobacilli.
Possible mechanisms of salt stress response in the halotolerant bacterial strain Exiguobacterium sp. SH31 isolated from Salar de Huasco.
The c-di-GMP signal transduction network of bacterial acidophiles.

Proyecto (27)

Análisis metagenómico de la diversidad microbiana y de la adaptación a metales en el área geotermal Caviahue-Copahue. Aplicaciones en biominería y en biorremediación.
Study of the function of histone-like proteins in the regulation of gene expression of mobile genetic element encoded-genes in acidophilic bioleaching bacteria. (Postdoctorate sponsor of Simón Beard Borquez)
Implementación de un método de control selectivo de la viabilidad de microorganismos relevantes en biominería.
Análisis de las poblaciones microbianas del botadero San Francisco de la mina Los Bronces e implementación de un programa de monitoreo.
Análisis de poblaciones microbianas en ripios y soluciones industriales de biolixiviación.
Detección de virus microbianos en soluciones industriales de biolixiviación.
Evaluación de la participación de componentes de la vía del Cdi- GMP que forman parte de elementos genéticos móviles en la formación de biopelículas de Acidithiobacillus.(Postdoctorate sponsor of Matías Castro)
Aislamiento y caracterización de microorganismos hierro-azufre oxidantes desde operaciones mineras para el diseño y preparación de consorcios biolixiviantes.
Desarrollo y validación de una estrategia de etiquetado genómico para el monitoreo especie-específico de poblaciones microbianas de biolixiviación.
Desarrollo y validación de una estrategia de etiquetado genómico para el monitoreo especie-específico de poblaciones microbianas de biolixiviación. (Postdoctorate sponsor of Lillian Acuña)
The role of the core and flexible genomes of Acidithiobacillus species in differentiation and niche adaptation.
Comparative genomic, metagenomic and bioinformatic approaches to generating fundamental and applied knowledge for bioleaching and other acidic econiches.
Development of an integrative pipeline for mobile genetic elements prediction in metagenomes. (Postdoctorate sponsor of Francisco Ossandon)
Molecular biodiversity studies of heap bioleaching systems using high resolution Multi Locus Sequence Typing.
Population structure analysis of microbial consortia driving bioleaching using genetic markers and high resolution typification strategies. (Postdoctorate sponsor of Harold Nuñez)
Role of regulatory RNAs in the response of acidophilic, bioleaching microorganisms to environmental challenges.
Virus population dynamics and acquired virus resistance in bioleaching microbial communities.
Whole Genome Sequencing, annotation and metabolic reconstruction of Sulfobacillus thermosulfidooxidans CBAR13.
Development of dedicated DNA arrays for screening of industrial transcriptomes.
Genomic and Bioinformatic Approaches to Discover and Apply Biological Knowledge to Improve Copper Bioleaching.
Comparative genomic modeling of the metabolism of microbial biomining consortia.
Iron homeostasis strategies in acidophilic iron oxidizers: comparative genomic analyses and experimental validations in Acidithiobacillus ferrooxidans.
Global protein-DNA binding site analysis in Acidithiobacillus ferrooxidans: a microarray based genomic mapping of protein binding sites for the iron responsive transcriptional regulator Fur.
El Tatio geysers field as a model system to study virus-host interactions and local adaptations.
International Cooperation: Comparative genomic modeling of the metabolism of microbial biomining consortia.
Millennium  Nucleus in  the  Biology  of  Intestinal  Microbiota
Understanding genomic diversity of the Acidithiobacillus complex in the context of evolutionary ecology.

Review (3)

Endogenous and Foreign Nucleoid-Associated Proteins of Bacteria: Occurrence, Interactions and Effects on Mobile Genetic Elements and Host's Biology
Lessons from the genomes of extremely acidophilic bacteria and archaea with special emphasis on bioleaching microorganisms
Acidithiobacillus ferrooxidans metabolism: from genome sequence to industrial applications
161
Raquel Quatrini

Research Associate

Fundación Ciencia & Vida

Santiago, Chile

35
David Holmes

Head, Laboratory of Bioinformatics and Genome Biology

Center for Bioinformatics and Genome Biology

FUNDACION CIENCIA & VIDA

Santiago, Chile

16
Paulo Covarrubias

Profesional

Genética Molecular

Instituto de Salud Pública

Santiago, Chile

14
Juan Cardenas

Assistant Professor

Universidad Mayor de Chile

Santiago, Chile

12
Jorge Valdes

I

CENTRO DE GENOMICA Y BIOINFORMATICA

UNIVERSIDAD MAYOR

Santiago, Chile

5
Inti Pedroso

Profesor Asistente

Facultad de Ciencias

Universidad Mayor

Santiago, Chile

4
Harold Nuñez

PostDoc

FUNDACIÓN CIENCIA PARA LA VIDA

Santiago, Chile

4
Pedro Galleguillos

Investigador Titular

Minería

CICITEM

Antofagasta, Chile

4
Claudia Lefimil

Profesor Asistente

Instituto de Investigación en Ciencias odontológicas

UNIVERSIDAD DE CHILE

Santiago, Chile

4
RODRIGO FLORES

Investigador

Biología Celular y Molecular

Universidad de Chile

Macul, Chile

3
Héctor Osorio

Postdoctorado

Departamento Genética Molecular y Microbiología

Pontificia Universidad Católica de Chile

Santiago, Chile

3
LILLIAN ACUÑA

INVESTIGADOR POST-DOCTORAL FONDECYT

Laboratorio de Genética y Patógenesis Bacteriana

Universidad Andrés Bello

SANTIAGO, Chile

3
Cecilia Demergasso

Directora

Vicerrectoría de Investigación y Desarrollo Tecnológico

UNIVERSIDAD CATÓLICA DEL NORTE

Antofagasta, Chile

3
Francisco Moya

Postdoctoral Associate

Medicina

MICROB-R

Santiago, Chile

3
Omar Orellana

Profesor Titular

Programa de Biología Celular y Molecular

FACULTAD DE MEDICINA, UNIVERSIDAD DE CHILE

Santiago, Chile

3
Gloria Levican

Académica Profesora Titular

Departamento de Biología

UNIVERSIDAD DE SANTIAGO DE CHILE

Santiago, Chile

3
Matías Castro

Investigador

Ingeniería y Tecnología

Universidad San Sebastián

Concepción, Chile

3
Mauricio Acosta

Investigador

Universidad Católica del Norte

Antofagasta, Chile

2
Mauricio Arenas

Profesor Asistente

Bioinformática

UNIVERSIDAD DE TALCA

talca, Chile

2
Pablo Valenzuela

Founder and Scientific Director

Fundación Ciencia & Vida

Santiago, Chile

1
Sebastian Valenzuela

Director de Area Veterinaria

Area Veterinaria

Fundación Ciencia para la Vida

Santiago, Chile

1
Jose Reyes

Académico Jornada Completa

Bioinformática

UNIVERSIDAD DE TALCA

Talca, Chile

1
José Pérez

Associate Professor

Biologia

Universidad Andres Bello

Santiago, Chile

1
Mario Vera

Profesor Asistente

Instituto de Ingeniería Biológica y Medica

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

Santiago, Chile

1
Marlén Barreto

Profesor asociado

UNIVERSIDAD AUTONOMA DE CHILE

Santiago de Chile, Chile

1
Nicolas Guiliani

Profesor Titular

Biología

UNIVERSIDAD DE CHILE

Santiago, Chile

1
Camila Salazar

Investigador

Biomédico

Universidad de Antofagasta

Antofagasta, Chile

1
Claudia Muñoz

Investigador

Biología

Universidad de Santiago de Chile

Santiago, Chile

1
Roberto Molina

Investigador Científico

Biología

Centro de Estudios Científicos

Valdivia, Chile

1
Coral Pardo

Investigador postdoctoral

Universidad Andrés Bello

Santiago, Chile

1
Andres Castillo

Investigador

Laboratorio Biomédico

Instituto de Salud Pública

Santiago, Chile

1
Claudia Saavedra

Full Professor

Departmento de Ciencias de la Vida

UNIVERSIDAD ANDRÉS BELLO

Santiago, Chile

1
FRANCISCO REMONSELLEZ

Professor

Ingenieria Química

UNIVERSIDAD CATÓLICA DEL NORTE

Antofagasta, Chile

1
Braulio Valdebenito

.

.

.

TALCA, Chile

1
Mario Tello

Académico

Biología

Universidad de Santiago de Chile

Santiago, Chile

1
Pedro Galleguillos

Investigador

Centro de Investigación Científico y Tecnológico para la Minería

Antofagasta, Chile

1
Alex Schwarz

PROFESOR ASOCIADO

INGENIERIA CIVIL

UNIVERSIDAD DE CONCEPCIÓN

Concepción, Chile

1
Sabrina Marín

Investigadora

Centro de Biotecnología CBAR

Universidad Católica del Norte

Antofagasta, Chile

1
Eduardo Castro

Associate Professor

Center for Bioinformatics and Integrative Biology

UNIVERSIDAD ANDRES BELLO

Santiago, Chile

1
Ivan Nancucheo

Docente Investigador

Universidad San Sebastián

Concepción, Chile

1
Lorena Escudero

Investigador

Medio ambiente

CICITEM

Antofagasta, Chile

1
Claudia Ibacache

Academic

Universidad de Valparaíso

Valparaíso, Chile

1
Alejandro Dinamarca

Investigador

Escuela de Nutrición y Dietética

CENTRO DE MICRO-BIOINNOVACIÓN UNIVERSIDAD DE VALPARAÍSO

Valparaíso, Chile

1
Claudio Vasquez

Full Professor

Biology Department

UNIVERSIDAD DE SANTIAGO DE CHILE

Santago, Chile

1
Juan Castro

Post-Doctorante

Universidad Católica del Norte

Antofagasta, Chile

1
Maria Loyola

Principal Investigator

Fundación Ciencia & Vida

Santiago, Chile

1
Renato Chavez

Full Professor

Biology

UNIVERSIDAD DE SANTIAGO DE CHILE

Santiago, Chile

1
Claudia Pareja

Postdoc

Departamento de Hematología-Oncología

Pontificia Universidad Católica de Chile

Santiago, Chile

1
Gonzalo Riadi

Assistant Professor

Bioinformatics

Universidad de Talca

Talca, Chile

1
Pablo Aguilar

PostDoc researcher

Instituto Antofagasta

Universidad de Antofagasta

Antofagasta, Chile

1
Susan Bueno

Profesor Asociado

Genética Molecular y Microbiología

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

Santiago, Chile