Man

Paulo César Covarrubias Pizarro

Profesional

Instituto de Salud Pública

Santiago, Chile

Líneas de Investigación


Bioquímico y Doctor en Biociencias Moleculares, con más de 15 años de experiencia en investigación y desarrollo, especializado en microbiología, biología molecular y tecnologías de secuenciación masiva.

Educación

  •  Biociencias Moleculares, UNIVERSIDAD ANDRES BELLO. Chile, 2019
  •  Bioquímico, UNIVERSIDAD DE SANTIAGO DE CHILE. Chile, 2008

Experiencia Profesional

  •   Technical Lead Full Time

    uBiome

    Santiago, Chile

    2017 - 2019

  •   Ayudante de Investigación Full Time

    Fundación Ciencia & Vida

    Santiago, Chile

    2007 - 2012

  •   Investigador Full Time

    Instituto de Salud pública

    Santiago, Chile

    2020 - A la fecha


 

Article (21)

Cross-species and mammal-to-mammal transmission of clade 2.3.4.4b highly pathogenic avian influenza A/H5N1 with PB2 adaptations

Pardo-Roa, Catalina; Nelson, Martha I.; Ariyama, Naomi; Aguayo, Carolina; Almonacid, Leonardo I.; Gonzalez-Reiche, Ana S.; Munoz, Gabriela; Ulloa, Mauricio; Avila, Claudia; Navarro, Carlos; et al.

Article ISI
NATURE COMMUNICATIONS  (2025)

The first reported case of human infection with H5N1 avian Influenza A virus in Chile

Castillo, Andres; Fasce, Rodrigo; Andrade, Winston; Covarrubias, Paulo; Hueche, Andrea; Campano, Constanza; Araya, Maykol; Bustos, Patricia

Article ISI
JOURNAL OF TRAVEL MEDICINE  (2023)

A novel sequencing-based vaginal health assay combining self-sampling, HPV detection and genotyping, STI detection, and vaginal microbiome analysis

Bustamante, Juan P.; Addae, Kwasi; Alegria-Mera, Victor; Bravo, Cristian; Bravo, Denisse; Carson, Glenn A.; Caughey, Adam; Gass, Graham; Gupta, Sarah L.; Harman, Kira; et al.

Article ISI
PLOS ONE  (2019)

Insights into the biology of acidophilic members of the Acidiferrobacteraceae family derived from comparative genomic analyses

Bellenberg, Soeren; Sand, Wolfgang; Vera, Mario

Article ISI SCOPUS
RESEARCH IN MICROBIOLOGY  (2018)

Occurrence, integrity and functionality of AcaML1-like viruses infecting extreme acidophiles of the Acidithiobacillus species complex

Moya-Flores, Francisco; Tapia, Pablo S.; Spinelli, Silvia

Article ISI SCOPUS
RESEARCH IN MICROBIOLOGY  (2018)

16S rRNA and Multilocus Phylogenetic Analysis of the Iron Oxidizing Acidophiles of the Acidiferrobacteraceae Family

Issotta, Francisco; Bellenberg, Sören; Thyssen, Christian; Mena, Cristóbal; Vera Véliz, Mario

Article SCOPUS
Solid State Phenomena  (2017)

Are there Viruses in Industrial Bioleaching Econiches?



Article SCOPUS
Solid State Phenomena  (2017)

Draft genome sequence of the type strain of the sulfur-oxidizing acidophile, Acidithiobacillus albertensis (DSM 14366)



Article ISI SCOPUS
Standards in Genomic Sciences  (2017)

Genetic Basis of Metal Resistance in Acidiphilium sp. DSM 27270 (Yenapatur)

Issotta, Francisco

Article SCOPUS
Solid State Phenomena  (2017)

Metagenome-Derived Draft Genome Sequence of Acidithiobacillus ferrooxidans RV1 from an Abandoned Gold Tailing in Neuquén, Argentina

Ulloa, Ricardo; Issotta, Francisco; Donati, Edgardo R.; Giaveno, Alejandra

Article SCOPUS
Solid State Phenomena  (2017)

Molecular Systematics of the Genus Acidithiobacillus: Insights into the Phylogenetic Structure and Diversification of the Taxon

Issotta, Francisco; Atavales, Joaquín; Johnson, D. Barrie

Article SCOPUS
Frontiers in Microbiology  (2017)

Type IV Secretion Systems Diversity in the Acidithiobacillus Genus

Flores-Ríos, Rodrigo

Article SCOPUS
Solid State Phenomena  (2017)

Detection, identification and typing of Acidithiobacillus species and strains: a review

Atavales, J

Article ISI SCOPUS
RESEARCH IN MICROBIOLOGY  (2016)

Draft genome sequence of chloride-tolerant Leptospirillum ferriphilum Sp-Cl from industrial bioleaching operations in northern Chile

Issotta, Francisco; Moya-Beltran, Ana; Davis-Belmar, Carol; Rautenbach, George; Acosta, Mauricio; Contador, Yasna

Article ISI SCOPUS
STANDARDS IN GENOMIC SCIENCES  (2016)

Draft genome sequence of the nominated type strain of "Ferrovum myxofaciens,"" an acidophilic, iron-oxidizing betaproteobacterium"



Article SCOPUS
Genome Announcements  (2014)

Architecture and Gene Repertoire of the Flexible Genome of the Extreme Acidophile Acidithiobacillus caldus

Acuña LG; Covarrubias PC; Haristoy JJ; Flores R.; Núñez H; Riadi G.; Shmaryahu, A; Valdés J.; Dopson, M; Rawlings DE; et al.

Article ISI SCOPUS
PLOS ONE  (2013)

Comparative genomics of the oxidative stress response in bioleaching microorganisms

Cardenas J.P.; Moya, F; Covarrubias P; Shmaryahu, A; Levicán G; Quatrini, R

Article ISI SCOPUS
Hydrometallurgy  (2012)

Complete Genome Sequence of Temperate Bacteriophage AcaML1 from the Extreme Acidophile Acidithiobacillus caldus ATCC 51756

Tapia, P; Flores F M.; Covarrubias, P. C.; Quatrini, R

Article ISI SCOPUS
Journal of Virology  (2012)

ICEAfe1, an Actively Excising Genetic Element from the Biomining Bacterium Acidithiobacillus ferrooxidans

Bustamante, P; Covarrubias PC; Levicán G; Katz, A; Tapia, P; Holmes D; Quatrini, R; Orellana O.

Article ISI SCOPUS
Journal of Molecular Microbiology and Biotechnology  (2012)

The Escherichia coli BtuE Protein Functions as a Resistance Determinant against Reactive Oxygen Species

Covarrubias PC; Sandoval, JM; Perez-Donoso, JM; Imlay, JA; Vásquez CC

Article ISI SCOPUS
PLOS ONE  (2011)

Selection and evaluation of reference genes for improved interrogation of microbial transcriptomes: case study with the extremophile Acidithiobacillus ferrooxidans

Nieto, PA; Covarrubias PC; Jedlicki, E; Holmes, DS; Quatrini, R

Article ISI SCOPUS
BMC MOLECULAR BIOLOGY  (2009)

ConferencePaper (1)

Predicted CO/CO(2) fixation in Ferroplasma spp. via a novel chimaeric pathway

Martínez V; Covarrubias P; Holmes, DS; Quatrini, R

ConferencePaper ISI
BIOHYDROMETALLURY: FROM THE SINGLE CELL TO THE ENVIRONMENT  (2009)

Patent (4)

Method and system for characterization for female reproductive system-related conditions associated with microorganisms

APTE ZACHARY?[US]; BIK ELISABETH?[US]; BIRD SARA W?[US]; LEON LUIS E?[CL]; NIETO PAMELA A?[CL]; ALEGRIA-MERA VICTOR?[CL]; BRAVO CRISTIAN?[CL]; CARDENAS JUAN P?[CL]; COVARRUBIAS PAULO?[CL]; GUPTA SARAH L?[US]; HARMAN KIRA?[US]; JIMENEZ JUAN?[CL]; MELIS-ARC

Patent
 

Method and system for library preparation with unique molecular identifiers.

Apte Z; Richman J; Almonacid D; Jimenez J; Ortiz R; Morales E; Covarrubias PC; Olivares E; Ordenes N Leon L.

Patent
 

Normalization for sequencing libraries.

Apte Z; Richman J Almonacid D; Morales E; Ortiz R; Ordenes N; Jimenez J; Bravo C; Scioscia N; Olivares E; Leon L; Covarrubias PC; Sepulveda F; Melis F (

Patent
 

Therapeutic & diagnostics compositions targeting toll-like receptors and methods thereof.

Apte Z; Richman J; Almonacid D; Alegria M; Marquez V; Morales E; Ortiz R; Torres J; Covarrubias PC; Gimpel J; Araya I.

Patent
 

Proyecto (2)

Desarrollo y validación de una estrategia de etiquetado genómico para el monitoreo de poblaciones bacterianas de biolixiviación

FONDEF (CA13I10162)

Proyecto
2014-2015
Tesista

Virus population dynamics and acquired virus resistance in bioleaching microbial communities

FONDECYT (1100887)

Proyecto
2010-2013
Tesista

1
José Pérez

Associate Professor

Biologia

Universidad Andres Bello

Santiago, Chile

1
Cecilia Demergasso

Directora

Centro de Biotecnología "Profesor Alberto Ruiz"

UNIVERSIDAD CATÓLICA DEL NORTE

Antofagasta, Chile

9
David Holmes

Head, Laboratory of Bioinformatics and Genome Biology

Center for Bioinformatics and Genome Biology

FUNDACION CIENCIA & VIDA

Santiago, Chile

1
Denisse Bravo

Profesora Titular

Odontología

Universidad Andrés Bello

Santiago, Chile

1
Claudio Vasquez

Full Professor

Biology Department

UNIVERSIDAD DE SANTIAGO DE CHILE

Santago, Chile

1
Omar Orellana

Profesor Titular

Programa de Biología Celular y Molecular

FACULTAD DE MEDICINA, UNIVERSIDAD DE CHILE

Santiago, Chile

2
Gloria Levican

Académica Profesora Titular

Departamento de Biología

UNIVERSIDAD DE SANTIAGO DE CHILE

Santiago, Chile

1
Felipe Arenas

Profesor Asociado

Biología

UNIVERSIDAD SANTIAGO DE CHILE

Santiago, Chile

3
Harold Nuñez

PostDoc

FUNDACIÓN CIENCIA PARA LA VIDA

Santiago, Chile

1
Katia Soto

Académica

Universidad de Chile

Santiago, Chile

1
Jorge Valdes

PROFESOR ASOCIADO

CENTRO DE BIOINFORMÁTICA Y BIOLOGÍA INTEGRATIVA

Universidad Andrés Bello

Santiago, Chile

1
Paula Bustamante

docente-investigador

Instituto de Ciencias Biomédicas

Universidad Autónoma de Chile

Santiago, Chile

1
Pedro Galleguillos

Investigador Titular

Minería

CICITEM

Antofagasta, Chile

1
Luis Leon

Head of Bioinformatics and Computational Biology

Technology

PhageLab

Santiago, Chile

1
Sabrina Marin

Profesor(a) Adjunto(a)

Centro de Biotecnología CBAR

Universidad Católica del Norte

Antofagasta, Chile

1
Mario Vera

Profesor Asociado

Instituto de Ingeniería Biológica y Medica

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

Santiago, Chile

1
Juan Jiménez

Investigador I+D Senior

Multiplex SpA

Santiago, Chile

1
CRISTIAN BRAVO

Profesional

Laboratorio Biomédico

Instituto Salud Publica

Santiago, Chile

17
Raquel Quatrini

Research Associate

Fundación Ciencia & Vida

Santiago, Chile

3
LILLIAN ACUÑA

INVESTIGADOR POST-DOCTORAL FONDECYT

Laboratorio de Genética y Patógenesis Bacteriana

Universidad Andrés Bello

SANTIAGO, Chile

1
Catalina Pardo

Profesor Asistente

Dpto. de Salud del Niño y Adolescente

Pontificia Universidad Católica de Chile

Region Metropolitana, Chile

9
Ana Moya

Profesor Asistente

Departamento de Informática y Computación

Universidad Tecnológica Metropolitana

Ñuñoa, Chile

1
Juan Ugalde

Assistant Professor

Facultad de Ciencias de la Vida

Universidad Andrés Bello

Santiago, Chile

7
Juan Cardenas

Assistant Professor

Centro de Genómica y Bioinformatica

Universidad Mayor

Santiago, Chile

1
Andres Castillo

Investigador

Laboratorio Biomédico

Instituto de Salud Pública

Santiago, Chile

26
Paulo Covarrubias

Profesional

Biomédico

Instituto de Salud Pública

Santiago, Chile

3
Francisco Moya

Postdoctoral Associate

Medicina

MICROB-R

Santiago, Chile

1
Rodrigo Fasce

Jefe Subdepto. Enfermedades Virales

Biomédico

Instituto de Salud Pública

Santiago, Chile

2
RODRIGO FLORES

Investigador

Biología Celular y Molecular

Universidad de Chile

Macul, Chile

2
Patricio Martinez

Director Biominería

Centro de Biotecnología de Sistemas

UNAB

Santiago, Chile

1
Gonzalo Riadi

Assistant Professor

Bioinformatics

Universidad de Talca

Talca, Chile

9
Francisco Issotta

Investigador Postoctoral

Genética Molecular y Microbiología

Pontificia Universidad Católica de Chile

Santiago, Chile