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ramon rogelio latorre de la cruz

Profesor

Universidad de Valparaíso

5, Chile

Estructura y FunciÃ³n de los canales de iones; ReconstituciÃ³n de canales de iones; Simulacion molecular; Proteinas de Membrana; Bioquimica Computacional; BioinformÃ¡tica; SimulaciÃ³n Molecular; NanobiotecnologÃa

Profesor Full Time

Universidad de Chile

Santiago, Chile

1983 - 2000

El Profesor ramon Latorre ha entrenado 30 doctores, 9 magister, 14 estudiantes de pregrado de diferentes carreras y 14 postdoctorantes

El profesor Latorre junto con Claudio Bunster fundó el año 1983 el Centro Cientificode Santiago, con residenci luego en Valdivia
Creó el año 2008 Instituto Milenio Centro Interdisciplinario de Neurociencia de Valparaiso y a través de este Instituto y sus programas de outreach a diseminado la Ciencia y la Neurociencia en Chile.

Elizabeth Cole Award

Biophysical Society

Estados Unidos, 1989

Giver for: A significant advance in Biophysics which is accepted and used by others in the field
John Simon Guggenheim Memorial Foundation Fellowship

JOHN SIMON GUGGENHEIM MEMORIAL FOUNDATION

Chile, 1990

Granted through a proposal on Structure and function of Ion channels
Third World Academy of Sciences Award in Biology

THIRD WORLD ACADEMY OF SCIENCES

Italia, 1991

For Important Advances in the Field of Biophysics
Miembro de la Academia de Ciencias de América Latina

Academia de Ciencias de América Latina

Venezuela, 1993

Por su destacado papel en el campo de la biofísica y en la diseminación de la Ciemcia en América Latina
Catédra Presidencial en Ciencias

UNIVERSIDAD DE CHILE

Chile, 1996

Concurso competitivo. Proyecto: Estructura y Función de canales de potasio activados por calcio
Medalla Rectorial

UNIVERSIDAD DE CHILE

Chile, 1996

Por su papel en el desarrollo de la ciencia en la Universidad de Chile en particular y en Chile en general
Fellow of the Third World Academy of Sciences

THIRD WORLD ACADEMY OF SCIENCES

Italia, 1997

For his advances in the field of ion channels
Corresponding Member of the Brazilian Academy of Sciences

Academia de Ciencias de Brasil

Brasil

For his role of the development of Science in latin America
Foreigh Associate of the National Academy of the United States of America

NATIONAL ACADEMY OF SCIENCE

Estados Unidos, 1999

For his novel advances in the field of Biophysics
Miembro de la Academia Chilena de Ciencias

ACADEMIA CHILENA DE CIENCIAS

Chile, 2002

Por su papel en el desarrollo de la ciencia en Chile
Robert F Kennedy Professor in Latin American Studies

HARVARD UNIVERSITY

Estados Unidos, 2003

For his distinguish role in the development of science in Latin America
Visiting Scholar

UNIVERSITY OF CHICAGO

Chile, 2007

Given to distiguished scientists all over the world
Premio México en Ciencia y Tecnología

GOBIERNO DE MEXICO

México, 2008

Este premio otorgado a científicos de América Latina excepto México y España y Portuga fue concedido por el Presidente de méxico por la destacada carrera cientifica en el campo de la biofísca de canales de iones y su labor en la diseminación de la ciencia en América Latina
Dr Honoris Causa

UNIVERSIDAD DE LA REPUBLICA URUGUAY

Uruguay, 2012

Por sus contribuciones a la Ciencia y su papel de educado en América latina


A folding reaction at the C-terminal domain drives temperature sensing in TRPM8 channels Raddatz, Natalia Article ISI PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2020)
Dynamin-2 R465W mutation induces long range perturbation in highly ordered oligomeric structures Neely, Alan; Marabol, Vanessa; Rojas, Maximiliano Article ISI Scientific Reports (2020)
Loss-of-function BK channel mutation causes impaired mitochondria and progressive cerebellar ataxia Staisch J.; Hain T.; Petrossian N. Article ISI SCOPUS PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2020)
TRPV1-Estradiol Stereospecific Relationship Underlies Cell Survival in Oxidative Cell Death Lozano, Carlo; Diaz, Paula; Marchant, Ivanny; Olivero, Pablo Article ISI FRONTIERS IN PHYSIOLOGY (2020)
Calcium-driven regulation of voltage-sensing domains in BK channels Castillo,Karen; Alvarez, Osvaldo; Latorre, Ramon Article ISI SCOPUS ELIFE (2019)
The molecular nature of the 17 beta-Estradiol binding site in the voltage- and Ca2+-activated K+ (BK) channel beta 1 subunit SepÃºlveda R.V.; Lorenzo-Ceballos Y. Article ISI SCOPUS Scientific Reports (2019)
Zoledronic Acid Modulation of TRPV1 Channel Currents in Osteoblast Cell Line and Native Rat and Mouse Bone Marrow-Derived Osteoblasts: Cell Proliferation and Mineralization Effect Scala, R; Maqoud, F; Angelelli, M; Perrone, MG; Scilimati, A; Tricarico, D Article ISI SCOPUS CANCERS (2019)
Demonstration of ion channel synthesis by isolated squid giant axon provides functional evidence for localized axonal membrane protein translation. Mathur, Chhavi; Johnson, Kory R; Tong, Brian A; Miranda, Pablo; Srikumar, Deepa; Basilio, Daniel; Latorre, Ramon; Bezanilla, Francisco; Holmgren, Miguel Article Scientific reports (2018)
Determination of the Stoichiometry between Î±- and Î³1 Subunits of the BK Channel Using LRET. Carrasquel-Ursulaez, Willy; Alvarez, Osvaldo; Bezanilla, Francisco; Latorre, Ramon Article Biophysical journal (2018)
Gating charge displacement in a monomeric voltage-gated proton (Hv1) cannel Carmona, E; Larsson, HP; Neely, A; Alvarez, O; Latorre, R*; and Gonzalez, C. Article PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2018)
The syndromic deafness mutation G12R impairs fast and slow gating in Cx26 hemichannels Garcia, Isaac E; Contreras, Gustavo F.; Pupo, Amaury; Alvarez, Osvaldo; Latorre, Ramon; Martinez, Agustin D. Article ISI SCOPUS JOURNAL OF GENERAL PHYSIOLOGY (2018)
Thermally activated TRP channels=> molecular sensors for temperature detection. Castillo, Karen; Diaz-Franulic, Ignacio; Canan, Jonathan; Gonzalez-Nilo, Fernando; Latorre, Ramon Article Physical biology (2018)
Calcium binding and voltage gating in Cx46 hemichannels. Pinto, B.I; Pupo, A; Garcia, I.; Martínez, A; Latorre, R; . and Gonzalez, C Article SCIENTIFIC REPORTS (2017)
Molecular Determinants of BK Channel Functional Diversity and Functioning Latorre, Ramon; Castillo, Karen; Carrasquel-Ursulaez, Willy; Sepulveda, Romina V.; Gonzalez-Nilo, Fernando; González, Carlos; Alvarez, Osvaldo Article Physiological Reviews (2017)
The enduring legacy of the "constant-field equation" in membrane ion transport. Alvarez, Osvaldo; Latorre, Ramon Article The Journal of general physiology (2017)
Allosterism and Structure in Thermally Activated Transient Receptor Potential Channels. Diaz-Franulic, Ignacio; Poblete, Horacio; Miño-Galaz, Germán; González, Carlos; Latorre, Ramón Article Annual review of biophysics (2016)
beta 1-subunit-induced structural rearrangements of the Ca2+- and voltage-activated K+ (BK) channel Aguayo, D; Sepúlveda R.V.; Luk L.Y.P.; Kent S.B.H.; Gonzalez-Nilo, F. D.; Bezanilla, F; Latorre R. Article ISI SCOPUS PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2016)
Charged Residues at the First Transmembrane Region Contribute to the Voltage Dependence of the Slow Gate of Connexins. Pinto, Bernardo I; García, Isaac E; Pupo, Amaury; Retamal, Mauricio A; Martínez, Agustín D; Latorre, Ramón; González, Carlos Article The Journal of biological chemistry (2016)
Structure-Driven Pharmacology of Transient Receptor Potential Channel Vanilloid 1 Caceres-Molina, J.; Sepulveda, R. V. Article ISI SCOPUS Molecular Pharmacology (2016)
Hydrophobic interaction between contiguous residues in the S6 transmembrane segment acts as a stimuli integration node in the BK channel Carrasquel-Ursulaez, W; Contreras G.F.; Sepúlveda R.V.; Aguayo, D; Gonzalez-Nilo, F; Gonzalez, C.; Latorre R. Article ISI SCOPUS JOURNAL OF GENERAL PHYSIOLOGY (2015)
Mechanism of potassium ion uptake by the Na+/K+-ATPase Castillo JP; Rui, H; Basilio D.; Das A.; Roux, B; Latorre R.; Bezanilla, F; Holmgren M. Article ISI SCOPUS Nature Communications (2015)
Molecular Determinants of Phosphatidylinositol 4,5-Bisphosphate (PI(4,5)P-2) Binding to Transient Receptor Potential V1 (TRPV1) Channels Poblete, H.; Oyarzun, I; Olivero P.; Comer, J.; Zúñiga M; Sepúlveda R.V.; Baez-Nieto, D; Gonzalez-Nilo, F; Latorre R. Article ISI SCOPUS JOURNAL OF BIOLOGICAL CHEMISTRY (2015)
Molecular mechanism underlying beta 1 regulation in voltage- and calcium-activated potassium (BK) channels Castillo, K; Pupo, A; Torres, YP; Neely A.; Gonzalez, C.; Latorre R. Article ISI SCOPUS Proceedings of the National Academy of Sciences of the United States of America (2015)
Voltage-gated proton (H(v)1) channels, a singular voltage sensing domain Castillo,Karen; Pupo, Amaury; Baez-Nieto, David; Contreras, Gustavo F.; Morera, Francisco J.; Neely, Alan; Latorre, Ramon; Gonzalez, Carlos Article ISI SCOPUS FEBS Letters (2015)
Directionality of Temperature Activation in Mouse TRPA1 Ion Channel Can Be Inverted by Single-Point Mutations in Ankyrin Repeat Six Jabba S; Goyal, R; Sosa-Pagan, JO; Moldenhauer, H; Wu J.; Kalmeta B; Bandell M; Latorre R.; Patapoutian A; Grandl J Article ISI SCOPUS NEURON (2014)
Gating of Thermally Activated Channels Baez, D; Raddatz, N; Ferreira, G; Gonzalez, C.; Latorre R. Article SCOPUS Current Topics in Membranes (2014)
Temperature and Voltage Coupling to Channel Opening in Transient Receptor Potential Melastatin 8 (TRPM8) Raddatz, N; Gonzalez, C.; Alvarez, O; Latorre R. Article ISI SCOPUS JOURNAL OF BIOLOGICAL CHEMISTRY (2014)
The Pore-Domain of TRPA1 Mediates the Inhibitory Effect of the Antagonist 6-Methyl-5-(2-(trifluoromethyl)phenyl)-1H-indazole Moldenhauer, H; Latorre R.; Grandl J Article ISI SCOPUS PLOS ONE (2014)
A BK (Slo1) channel journey from molecule to physiology Castillo, K; Enrique, N; Carrasquel-Ursulaez, W; Castillo JP; Milesi, V; Neely A.; Alvarez, O; Ferreira, G; Gonzalez, C.; Latorre R. Article ISI SCOPUS Channels (2013)
De novo expression of connexin hemichannels in denervated fast skeletal muscles leads to atrophy Cisterna, BA; Puebla, C; Frank, M; Figueroa, XF; Cardozo C.; Willecke K.; Latorre R. Article ISI SCOPUS Proceedings of the National Academy of Sciences of the United States of America (2013)
Emerging Role of Calcium-Activated Potassium Channel in the Regulation of Cell Viability Following Potassium Ions Challenge in HEK293 Cells and Pharmacological Modulation Tricarico, D; Mele A; Calzolaro, S; Cannone, G; Camerino, GM; Dinardo, MM; Latorre R.; Camerino, DC Article ISI SCOPUS PLOS ONE (2013)
K+ Channels: Function-Structural Overview Gonzalez, C.; Baez-Nieto, D; Valencia I.; Oyarzun, I; Rojas P.; Naranjo, D; Latorre R. Article ISI SCOPUS Comprehensive Physiology (2012)
Modulation of BK channel voltage gating by different auxiliary beta subunits Contreras G.F.; Neely A.; Alvarez, O; Gonzalez, C.; Latorre R. Article ISI SCOPUS PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2012)
Splicing of the rSlo gene affects the molecular composition and drug response of Ca 2+-activated K + channels in skeletal muscle Camerino, G; Mele A; Conte Camerino D.; Tricarico, D; Latorre R. Article PLOS ONE (2012)
Splicing of the rSlo Gene Affects the Molecular Composition and Drug Response of Ca2+-Activated K+ Channels in Skeletal Muscle Camerino, G; Mele A; Latorre R.; Conte Camerino D.; Tricarico, D Article ISI SCOPUS PLOS ONE (2012)
The first transmembrane domain (TM1) of beta 2-subunit binds to the transmembrane domain S1 of alpha-subunit in BK potassium channels Morera F.J.; Alioua A.; Kundu P.; Salazar M.; Gonzalez, C.; Martinez A.D.; Stefani E.; Toro, L.; Latorre R. Article ISI SCOPUS FEBS Letters (2012)
Energy landscape of the reactions governing the Na+ deeply occluded state of the Na+/K+-ATPase in the giant axon of the Humboldt squid Castillo JP; De Giorgis, D; Basilio D.; Gadsby, DC; Rosenthal, JJC; Latorre R.; Holmgren M.; Bezanilla, F Article ISI SCOPUS Proceedings of the National Academy of Sciences of the United States of America (2011)
Thermo-TRP Channels: Biophysics of Polymodal Receptors Baez-Nieto, D; Castillo JP; Dragicevic C.; Alvarez, O; Latorre R. Article ISI SCOPUS Advances in Experimental Medicine and Biology (2011)
Allosteric interactions and the modular nature of the voltage- and Ca2+-activated (BK) channel Latorre R.; Zaelzer, C Article ISI SCOPUS Journal of Physiology (2010)
Cell volume and membrane stretch independently control K+ channel activity Hammami, S; Willumsen, NJ; Olsen, HL; Latorre R.; Klaerke, DA Article ISI SCOPUS JOURNAL OF PHYSIOLOGY-LONDON (2009)
TRANSPLANTABLE SITES CONFER TEMPERATURE AND PIP2 SENSITIVITY TO THERMO TRANSIENT RECEPTOR POTENTIAL (TRP) CHANNELS Latorre R. Article JOURNAL OF PHYSIOLOGICAL SCIENCES (2009)
Intrinsic electrostatic potential in the BK channel pore: Role in determining single channel conductance and block Carvacho I.; Gonzalez, W; Torres, YP; Brauchi, S.; Alvarez, O; Gonzalez-Nilo, FD; Latorre R. Article ISI JOURNAL OF GENERAL PHYSIOLOGY (2008)
Dissection of the components for PIP(2) activation and thermosensation in TRP channels Brauchi, S.; Orta, G; Mascayano, C; Salazar M.; Raddatz, N; Urbina, H; Rosenmann, E; Gonzalez-Nilo, F; Latorre R. Article ISI SCOPUS PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)
Thermo TRP channels as modular proteins with allosteric gating Latorre R.; Brauchi, S.; Orta, G; Zaelzer, C; Vargas G. Article ISI SCOPUS CELL CALCIUM (2007)
A hot-sensing cold receptor: C-terminal domain determines thermosensation in transient receptor potential channels Brauchi, S.; Orta, G; Salazar M.; Rosenmann, E; Latorre R. Article ISI SCOPUS JOURNAL OF NEUROSCIENCE (2006)
Ciencia: unidad en la variedad Latorre, Ramon; Moreno, María Elena Article SCIELO Atenea (Concepciï¿½n) (2006)
Structural determinants for functional coupling between the beta and alpha subunits in the Ca2+-activated K+ (BK) channel Orio, P; Torres Y.; Rojas P.; Carvacho I.; Garcia, ML; Toro, L.; Valverde, MA; Latorre R. Article ISI SCOPUS JOURNAL OF GENERAL PHYSIOLOGY (2006)
Differential effects of beta 1 and beta 2 subunits on BK channel activity Orio, P; Latorre R. Article ISI JOURNAL OF GENERAL PHYSIOLOGY (2005)
S3b amino acid residues do not shuttle across the bilayer in voltage-dependent Shaker K+ channels Gonzalez, C.; Rosenmann, E; Alvarez, O; Latorre R. Article ISI SCOPUS PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)
Clues to understanding cold sensation: Thermodynamics and electrophysiological analysis of the cold receptor TRPM8 Brauchi, S.; Orio, P; Latorre R. Article ISI SCOPUS PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2004)
Gain-of-function mutation in the KCNMB1 potassium channel subunit is associated with low prevalence of diastolic hypertension Fernandez-Fernandez, JM; Tomàs M.; Vazquez, E; Orio, P; Latorre R.; Senti, M; Marrugat, J; Valverde, MA Article ISI SCOPUS JOURNAL OF CLINICAL INVESTIGATION (2004)
Anion permeation in human CIC-4 channels Hebeisen, S; Heidtmann, H; Cosmelli, D; Gonzalez, C.; Poser, B; Latorre R.; Alvarez, O; Fahlke, C Article ISI BIOPHYSICAL JOURNAL (2003)
Molecular coupling between voltage sensor and pore opening in the Arabidopsis inward rectifier K+ channel KAT1 Latorre R.; Olcese, R; Basso, C; Gonzalez, C.; Muñoz F; Cosmellli, D; Alvarez, O Article ISI JOURNAL OF GENERAL PHYSIOLOGY (2003)
Structure and function of potassium channels in plants: some inferences about the molecular origin of inward rectification in KAT1 channels (Review) Ramon, L; Muñoz F; Gonzalez, C.; Cosmelli, D Article ISI MOLECULAR MEMBRANE BIOLOGY (2003)
Ca2+-activated K+ channel inhibition by reactive oxygen species Soto, MA; Gonzalez, C.; Lissi E.; Vergara C.; Latorre R. Article ISI AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY (2002)
Counting channels: A tutorial guide on ion channel fluctuation analysis Alvarez, O; Gonzalez, C.; Latorre R. Article ISI ADVANCES IN PHYSIOLOGY EDUCATION (2002)
New disguises for an old channel: MaxiK channel ?-subunits Orio, P; Rojas P.; Ferreira, G; Latorre R. Article SCOPUS NEWS IN PHYSIOLOGICAL SCIENCES (2002)
New disguises for an old channel: MaxiK channel beta-subunits Orio, P; Rojas P.; Ferreira, G; Latorre R. Article ISI NEWS IN PHYSIOLOGICAL SCIENCES (2002)
A conducting state with properties of a slow inactivated state in a Shaker K+ channel mutant Olcese, R; Sigg D.; Latorre R.; Bezanilla, F; Stefani E. Article ISI SCOPUS JOURNAL OF GENERAL PHYSIOLOGY (2001)
Actin modifies Ca2+ block of epithelial Na+ channels in planar lipid bilayers Berdiev, BK; Latorre R.; Benos, DJ; Ismailov, II Article ISI SCOPUS BIOPHYSICAL JOURNAL (2001)
Periodic perturbations in Shaker K+ channel gating kinetics by deletions in the S3-S4 linker Gonzalez, C.; Rosenman, E; Bezanilla, F; Alvarez, O; Latorre R. Article ISI PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2001)
Apical sorting of a voltage- and Ca2+-activated K+ channel alpha-subunit in Madin-Darby canine kidney cells is independent of N-glycosylation Bravo-Zehnder, M; Orio, P; Norambuena, A.; Wallner, M.; Meera, P; Toro, L.; Latorre R.; González A Article ISI SCOPUS PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2000)
Deletion of the S3-S4 linker in the Shaker potassium channel reveals two quenching groups near the outside of S4 Sorensen, JB; Cha, A; Latorre R.; Rosenman, E; Bezanilla, F Article ISI SCOPUS JOURNAL OF GENERAL PHYSIOLOGY (2000)
Modulation of the Shaker K+ channel gating kinetics by the S3-S4 linker Gonzalez, C.; Rosenman, E; Bezanilla, F; Alvarez, O; Latorre R. Article ISI JOURNAL OF GENERAL PHYSIOLOGY (2000)


Effects of the Accessory Subunit gamma 1 on the External Architecture of BK Channel Carrasquel-Ursulaez, W; Castillo JP; Lorenzo, Y; sepulveda, r; Aguayo, D; Bezanilla, F; Gonzalez-Nilo, FD; Latorre R. Abstract ISI BIOPHYSICAL JOURNAL (2015)
Proton Permeation in Ci-Hv1 Voltage-Gated Proton Channels occurs through a Proton Wire Involving Residues D160 and D222 and It is Modulated by N264 Pupo, A; Baez-Nieto, D; Otárola E.; Yanez, O.; Vergara-Jaque, A; Gonzalez, W; Castillo, K; Contreras, G.; Larsson, HP; Latorre R.; et al. Abstract ISI BIOPHYSICAL JOURNAL (2015)
Rational discovery of new capsaicin analogues as TRPV1 activators Caceres J.; sepulveda, r; Navas C.; Latorre R.; Gonzalez-Nilo, F Abstract ISI BMC BIOINFORMATICS (2015)
Residues Involved in Cx26 Hemichannels Voltage Dependent Gating Pinto, BI; Baez-Nieto, D; Pupo, A; Martínez, A.; Latorre R.; Gonzalez, C. Abstract ISI BIOPHYSICAL JOURNAL (2015)
Temperature and Voltage Coupling to TRPM8 Channel Opening Raddatz, N; Castillo JP; Gonzalez, C.; Alvarez, O; Latorre R. Abstract ISI BIOPHYSICAL JOURNAL (2015)
The Molecular Determinants of PI(4,5)P-2 Binding to TRPV1 Channels Poblete, H.; Oyarzun, I; Olivero P.; Comer, J.; Zúñiga M; sepulveda, r; Baez-Nieto, D; Gonzalez, C.; Gonzalez-Nilo, F; Latorre R. Abstract ISI BIOPHYSICAL JOURNAL (2015)
The Role of the Ion Dehydration Process in Low and High Conductance K Channels Bravo-Moraga, F; Diaz-Franulic, I; Aguayo, D; Naranjo, D; Latorre R.; Gonzalez-Nilo, FD Abstract ISI BIOPHYSICAL JOURNAL (2015)
Gating Currents of Monomeric Hv Channel Reveals a Permeation Pathway Coupled to the Voltage Activation Baez-Nieto, D; Otárola E.; Contreras, G.; Larsson P.; Latorre R.; Gonzalez, C. Abstract ISI BIOPHYSICAL JOURNAL (2014)
K+ Translocation by the Giant Axon of the Humboldt Squid Na+/K ATPase Castillo JP; Basilio D.; Latorre R.; Bezanilla, F; Holmgren M. Abstract ISI BIOPHYSICAL JOURNAL (2014)
Single-Point Mutations in Ankyrin Repeat Six Make Mouse TRPA1 Sensitive to Hot Temperatures Jabba, SV; Goyal, R; Moldenhauer, H; Kalmeta B; Bandell M; Latorre R.; Patapoutian A; Grandl J Abstract ISI BIOPHYSICAL JOURNAL (2014)
Single-Point Mutations in Ankyrin Repeat Six Make Mouse TRPA1 Sensitive to Warm Temperatures Jabba S; Goyal, R; Sosa-Pagan, JO; Moldenhauer, H; Wu J.; Kalmeta B; Bandell M; Latorre R.; Patapoutian A; Grandl J Abstract ISI JOURNAL OF GENERAL PHYSIOLOGY (2014)
Substitutions at F380 in S6 by Small Hydrophobic Amino Acids Makes the Opening Transition in BK Channels Rate Limiting Carrasquel-Ursulaez, W; sepulveda, r; Aguayo, D; Gonzalez-Nilo, FD; Gonzalez, C.; Latorre R. Abstract ISI BIOPHYSICAL JOURNAL (2014)
The Permeation Pathway Mechanism in Ciona Intestinalis Hv Channel Otárola E.; Baez-Nieto, DE; Contreras, G.; Yanez, O.; Castillo, K; Larsson P.; Latorre R.; Gonzalez, C. Abstract ISI BIOPHYSICAL JOURNAL (2014)
Bendroflumethiazide a potent opener of human BK channel : a new perspective for an old drug in the treatment of periodic paralysis Cannone, G; Calzolaro, S; Mele A; Camerino, GM; Dinardo, MM; Latorre R.; Conte, DC; Tricarico, D Abstract ISI FASEB JOURNAL (2013)
External Architecture of the Large-Conductance Ca2+ and Voltage-Activated K+ (BKCa) Revealed by a Spectroscopic Ruler Castillo JP; Sanchez-Rodriguez, JE; Hyde, HC; Zalezer, C; Aguayo, D; Kent, S; Gonzalez-Nilo, F; Bezanilla, F; Latorre R. Abstract ISI BIOPHYSICAL JOURNAL (2013)
Voltage-Dependence in Thermo-Voltage Sensitive Channel TRPV1. A Delocalized Voltage Sensor? Baez-Nieto, D; Alvarez, O; Brauchi, S.; Gonzalez, C.; Latorre R. Abstract ISI BIOPHYSICAL JOURNAL (2013)
Differential Effects of Beta Subunits on the Voltage Sensor of Ca2+ and Voltage-Activated K+ Channels Neely A.; Alvarez, O; Gonzalez, C.; Latorre R. Abstract ISI BIOPHYSICAL JOURNAL (2012)
Energetics of the Reactions Controlling the Deeply Occluded State of the Na+/K+ Pump Castillo JP; De Giorgis, D; Basilio D.; Gadsby, DC; Rosenthal, JJC; Latorre R.; Holmgren M.; Bezanilla, F Abstract ISI BIOPHYSICAL JOURNAL (2012)
The C Terminus is Responsible of the Thermo Sensitivity in TRPM8 Channels Raddatz, N; Baez-Nieto, D; Rosenmann, E; Neely A.; Gonzalez, C.; Alvarez, O; Latorre R. Abstract ISI BIOPHYSICAL JOURNAL (2012)
A Molecular Model for the Bkca Channel and the Location of B1 in the B1/A Subunit Complex Zaelzer, CA; Hyde, C.; Vergara A.; Poblete, H.; Aguayo, D; Sandtner, W; Gonzalez-Nilo, FD; Bezanilla, F; Latorre R. Abstract ISI BIOPHYSICAL JOURNAL (2010)
beta-Subunit transmembrane domains are required for functional coupling with alpha-subunit in BK channel Torres Y.; Raddatz, N; Rosenmann, E; Latorre R. Abstract ISI BIOPHYSICAL JOURNAL (2007)
Dissecting phosphatidylinositol 4,5-bisphosphate activation and thermosensation in TRP channels Orta, G; Salazar M.; Gonzalez, W; Mascayano, C; Raddatz, N; Rosenmann, E; Gonzalez-Nilo, F; Brauchi, S.; Latorre R. Abstract ISI BIOPHYSICAL JOURNAL (2007)
Effects of Acetazolamide on alpha subunit of human BK channel expressed in HEK293 cells Tricarico, D; Mele A; Latorre R.; Torres Y.; Camerino, DC Abstract ISI BIOPHYSICAL JOURNAL (2007)
External surface charge neutralization induces outward rectification on the calcium- and voltage-activated potassium channel BK Carvacho I.; Gonzalez, W; Orio, P; Brauchi, S.; Alvarez, O; Gonzalez-Nilo, FD; Latorre R. Abstract ISI BIOPHYSICAL JOURNAL (2007)
Determinant for temperature sensing in transient receptor potential channels Latorre R.; Rosenmann, E; Salazar M.; Brauchi, S. Abstract ISI PLACENTA (2006)
Biophysical characterization of the cold receptor CMR1 Brauchi, S.; Orio, P; Latorre R. Abstract ISI BIOPHYSICAL JOURNAL (2005)
Exploring the Shaker K+ channel S3b segment using deletion mutants. Gonzalez, C.; Rosenmann, E; Brauchi, S.; Gonzalez, W; Alvarez, O; González D; Latorre R. Abstract ISI BIOPHYSICAL JOURNAL (2005)
Lack of transmembrane movement of Shaker K+ channel S3b Gonzalez, C.; Rosenmann, E; Alvarez, O; Latorre R. Abstract ISI BIOPHYSICAL JOURNAL (2005)
Role of the electrostatic potential on the BK potassium channel conductance. Gonzalez-Nilo, FD; Gonzalez, W; Brauchi, S.; Orio, P; Carvacho I.; Rosenmann, E; Zaelzer, C; Latorre R. Abstract ISI BIOPHYSICAL JOURNAL (2005)
Displacement of S3 segment during activation of Shaker K+ channel with a short S3-S4 linker Gonzalez, CL; Morera, F; Muñoz F; Rosenmann, E; Alvarez, O; Latorre R. Abstract ISI BIOPHYSICAL JOURNAL (2004)
Molecular basis of BK modulation by beta subunits and channel activation by estrogens. Rojas P.; Orio, P; Carvacho I.; Torres Y.; Brauchi, S.; Garcia, ML; Toro, L.; Valverde, MA; Latorre R. Abstract ISI BIOPHYSICAL JOURNAL (2003)
The moving parts of the KAT1 K+ channel Muñoz F; Gonzalez, C.; Cosmelli, D; Alvarez, O; Latorre R. Abstract ISI BIOPHYSICAL JOURNAL (2003)
Domains of beta subunit involved in modulation of MaxiK channel modulation Rojas P.; Orio, P; Toro, L.; Garcia, ML; Latorre R. Abstract ISI BIOPHYSICAL JOURNAL (2002)
Effects of partial deletions of S3 segment in Shaker K+ channel activation kinetics Gonzalez, CL; Gonzalo, FDR; Rosenmann, EA; Bezanilla, F; Alvarez, OA; Latorre R. Abstract ISI BIOPHYSICAL JOURNAL (2002)
MaxiK channel activation by estradiol and tamoxifen: Role of the extracellular domain of the beta 1-subunit Orio, P; Rojas P.; Toro, L.; Latorre R. Abstract ISI BIOPHYSICAL JOURNAL (2002)
Inhibition of a Ca2+-activated K(+)channel by H2O2 Vergara C.; Soto M.; Gonzalez, C.; Lissi E.; Latorre R. Abstract ISI BIOPHYSICAL JOURNAL (2001)
Kat1, a K+ channel from Arabidopsis thaliana, possesses an intrinsic voltage sensor. Latorre R.; Basso, C; Gonzalez, C.; Alvarez, O; Cosmelli, D Abstract ISI BIOPHYSICAL JOURNAL (2001)
Periodic perturbations in Shaker K+ channel gating kinectics by deletions in the S3-S4 linker. Gonzalez, C.; Rosenmann, E; Bezanilla, F; Alvarez, O; Latorre R. Abstract ISI BIOPHYSICAL JOURNAL (2001)
A conducting slow inactivated Shaker channel? Olcese, R; Sigg, DM; Latorre R.; Stefani E.; Bezanilla, F Abstract ISI BIOPHYSICAL JOURNAL (2000)
Deletions in the S3-S4 linker modify Shaker K+ channel gating kinetics Gonzalez, C.; Rosenmann, E; Bezanilla, F; Alvarez, O; Latorre R. Abstract ISI JOURNAL OF PHYSIOLOGY-LONDON (2000)
Inhibition of Ca2+-dependent K+ channel currents by exposure to hydrogen peroxide Soto, MA; Gonzalez, C.; Lissi E.; Vergara C.; Latorre R. Abstract ISI JOURNAL OF PHYSIOLOGY-LONDON (2000)
Localisation of ion binding sites and modulation by oestrogens in a Ca2+-dependent K+ (MaxiK) channel Latorre R.; Vergara C.; Alvarez, O; Valverde, M Abstract ISI JOURNAL OF PHYSIOLOGY-LONDON (2000)
Modulations of the Shaker K+ channel activation kinetics by the S3-S4 linker Gonzalez, CL; Rosenmann, EA; Bezanilla, F; Alvarez, OA; Latorre R. Abstract ISI BIOPHYSICAL JOURNAL (2000)
The inward rectifier K+ channel, Kat1, from Arabidopsis thaliana possesses an intrinsic voltage sensor Cosmelli, D; Rosenmann, E; Basso, C; Alvarez, O; Latorre R. Abstract ISI JOURNAL OF PHYSIOLOGY-LONDON (2000)


Voltage-Dependent K+ Channels Latorre R.; Morera F.J.; Zaelzer, C; Lennarz, W.J.; Lane, D. BookSection (2013)
Mutagenesis and Temperature-Sensitive Little Machines Pertusa, M.; Moldenhauer, H; Brauchi, S.; Latorre R.; Madrid R.; Orio, P; Rajnikant Mishra BookSection (2012)


Methods for Investigating TRP Channel Gating BookWhole ISI SCOPUS NEISSERIA MENINGITIDIS (2019)
Biophysical and molecular features of thermosensitive TRP channels involved in sensory transduction Ferreira, G; Raddatz, N; Lorenzo, Y; Gonzalez, C.; Latorre R. BookWhole SCOPUS TRP Channels in Sensory Transduction (2015)
Signal transduction-dependent channels Latorre R.; Gonzalez, C.; Rojas P. BookWhole SCOPUS Neuroscience in the 21st Century: From Basic to Clinical (2013)


Allosteric interactions and the modular nature of the voltage- and Ca 2+-activated (BK) channel Latorre R.; Morera F.J.; Zaelzer, C ConferencePaper Journal of Physiology (2010)
Helical nature of the voltage sensor Alvarez, O; Rosenmann, E; Bezanilla, F; Gonzalez, C.; Latorre R. ConferencePaper ISI PUMPS, TRANSPORTERS, AND ION CHANNELS: STUDIES ON THEIR STRUCTURE, FUNCTION, AND CELL BIOLOGY (2005)


Keeping you healthy: BK channel activation by omega-3 fatty acids Latorre R.; Contreras, G. EditorialMaterial ISI SCOPUS Journal of General Physiology (2013)
Perspectives on TRP Channel Structure and the TRPA1 Puzzle Latorre R. EditorialMaterial ISI SCOPUS Journal of General Physiology (2009)


Save the lab in Montemar, Chile Borges R.; Viveros, OH; Latorre R. Letter ISI SCIENCE (2006)


GATING, ARCHITECTURE AND MODULATION BY BETA AND GAMMA SUBUNITS OF THE CALCIUM AND VOLTAGE-ACTIVATED POTASSIUM (BK) CHANNEL FONDECYT (1150273) Proyecto 2015-2019 Inv. Responsable
STUDY OF STRUCTURAL AND DYNAMIC PROPERTIES THAT GOVERN SELECTIVITY AND CONDUCTANCE OF K CHANNELS UNDER NON-EQUILIBRIUM CONDITIONS. FONDECYT (1131003) Proyecto 2013-2016 Coinvestigador(a)
DETERMINATION OF THE ARCHITECTURE AND DYNAMICS OF THE VOLTAGE- AND CALCIUM-ACTIVATED (BK) CHANNEL USING LANTHANIDE RESONANCE ENERGY TRANSFER (LRET) FONDECYT (1110430) Proyecto 2011-2015 Inv. Responsable
IONIC CONDUCTION IN K CHANNELS FONDECYT (1090493) Proyecto 2009-2012 Coinvestigador(a)
BASES MOLECULARES DE LA SENSIBILIDAD TERMICA EN MAMIFEROS. FONDECYT (1070049) Proyecto 2007-2011 Inv. Responsable
MECANISMOS ALOSTERICO EN LA ACTIVACION DEL CANAL TRPM8. FONDECYT (3060003) Proyecto 2006-2007 Inv. Patrocinante
ASPECTOS MOLECULARES QUE GOBIERNAN LA CONDUCTANCIA DE LOS CANALES DE POTASIO. FONDECYT (1040254) Proyecto 2004-2007 Coinvestigador(a)
MECANISMO MOLECULAR DEL ACOPLAMIENTO ENTRE UN CANAL DE K+ ACTIVADO POR CA2+ (BKca) Y SUS SUBUNIDADES MODULADORES B. FONDECYT (1030830) Proyecto 2003-2007 Inv. Responsable
DETERMINANTES MOLECULARES QUE MEDIAN LA ACTIVACION DEL CANAL DE LA PLANTA ARABIDOPSIS THALIANA KAT1 FONDECYT (1000890) Proyecto 2000-2003 Inv. Responsable
COMPONENTES MOLECULARES QUE MEDIAN ENTRE LA UNION DE CALCIO Y LA APERTURA DE UN CANAL DE POTASIO ACTIVADO POR CALCIO FONDECYT (1970739) Proyecto 1997-2000 Inv. Responsable


Pharmacological consequences of the coexpression of BK channel alpha and auxiliary beta subunits Torres, YP; Granados, ST; Latorre R. Review ISI SCOPUS FRONTIERS IN PHYSIOLOGY (2014)
Proton channel models Filling the gap between experimental data and the structural rationale Pupo, A; Baez-Nieto, D; Martínez, A.; Latorre R.; Gonzalez, C. Review ISI SCOPUS CHANNELS (2014)
Voltage sensor of ion channels and enzymes Contreras G.F.; Peyser A.; Larsson P.; Neely A.; Latorre R. Review SCOPUS Biophysical Reviews (2012)
A Cool Channel in Cold Transduction Latorre R.; Brauchi, S.; Madrid R.; Orio, P Review ISI SCOPUS Physiology (2011)
Acute and fulminant hepatitis induced by flutamide: Case series report and review of the literature Brahm, J; Brahm M.; Segovia R.; Latorre R.; Zapata, R; Poniachik, J; Buckel, E; Contreras, L. Review ISI SCOPUS Annals of Hepatology (2011)
Structure-functional intimacies of transient receptor potential channels Latorre R.; Zaelzer, C; Brauchi, S. Review ISI QUARTERLY REVIEWS OF BIOPHYSICS (2009)
A marriage of convenience: beta-subunits and voltage-dependent K+ channels Torres, YP; Carvacho I.; Latorre R. Review ISI JOURNAL OF BIOLOGICAL CHEMISTRY (2007)
Large conductance Ca2+-activated K+ (BK) channel: Activation by Ca2+ and voltage Latorre R.; Brauchi, S. Review ISI SCIELO BIOLOGICAL RESEARCH (2006)

Cecilia Vergara

Profesor Asociado

Biología

DEPARTAMENTO BIOLOGIA, FACULTAD DE CIENCIAS, U. DE CHILE

Santiago, Chile

Xavier Figueroa

Associate Professor

Departamento de Fisiologia

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

Felipe Simon

Profesor Titular

Department of Biological Sciences

UNIVERSIDAD ANDRES BELLO FAC DE CS BIOLOGICAS, DPTO DE CS BIOLOGICAS

Santiago, Chile

Marco Soto

Profesor Asociado

Química Física

Pontificia Universidad Católica de Chile

Santiago, Chile

125

ramon latorre

Profesor

Instituto de Neurociencia

Universidad de Valparaíso

5, Chile

Pablo Olivero

Profesor Adjunto

Patologia y Fisiologia

Universidad de Valparaiso

Valparaíso, Chile

Agustin Martinez

Profesor Titular

Instituto de Neurociencia

UNIVERSIDAD DE VALPARAÍSO, CENTRO INTERDISCIPLINARIO DE NEUROCIENCIAS DE VALPARAÍSO

Valparaíso, Chile

Carolina Mascayano

Académico

Ciencias del Ambiente

UNIVERSIDAD DE SANTIAGO DE CHILE, FACULTAD DE QUÍMICA Y BIOLOGIA

santiago, Chile

Luis González

Full Professor

School of Medicine

Universidad San Sebastián

Santiago, Chile

Diego Cosmelli

Profesor Asociado y Sub-director de Investigación y Postgrado

Escuela de Psicología

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

Santiago, Chile

Karen Castillo

Académica Investigadora

,Centro de Investigación de Estudios Avanzados del Maule (CIEAM)

Universidad Catolica del Maule

Talca, Chile

Ivanny Marchant

Directora Unidad de Estudios Clínicos

ESCUELA DE MEDICINA UNIVERSIDAD DE VALPARAISO

Valparaiso, Chile

Wendy Gonzalez

Director of the Center for Bioinformatics, Simulations and Modeling (CBSM)

Bioinformática

CENTRO DE BIOINFORMÁTICA Y SIMULACIÓN MOLECULAR (CBSM)/ UNIVERSIDAD DE TALCA

Talca, Chile

Ana Cárdenas

Professor

UNIVERSIDAD DE VALPARAÍSO

Valparaíso, Chile

Luis Cea

Profesor programa teaching

Instituto de Ciencias Biomédicas

Universidad Autónoma de Chile

Santiago, Chile

David Naranjo

Profesor titular

Neurociencia

Universidad de Valparaíso

VALPARAISO, Chile

Patricio Rojas

Assistant Professor

Departamento de Biologia

UNIVERSIDAD DE SANTIAGO DE CHILE

Santiago, Chile

Patricio Orio

Profesor Titular

UNIVERSIDAD DE VALPARAÍSO

Valparaíso, Chile

Fernando Gonzalez

Titular Professor

Facultad de Ciencias de la Vida

Universidad Andres Bello

Santiago, Chile

Carlos Puebla

Assistant Professor

Universidad de O'Higgins

Santiago, Chile

Francisco Morera

Assistant Professor

Pontificia Universidad Católica de Chile

Santiago, Chile

Daniel Aguayo

Associate Professor

ITISB

UNIVERSIDAD ANDRES BELLO

Viña del Mar, Chile

Juan Saez

Professor

Instituto de Neurociencias

Universidad de Valparaiso

Valparaíso, Chile

Sebastian Brauchi

Associate Professor

Physiology

Universidad Austral de Chile

Valdivia, Chile

Tomas Perez-Acle

Full Professor

Computational Biology Lab

Fundación Ciencia para la Vida

Santiago, Chile

Universidad Andrés Bello

Santiago, Chile

Ariela Vergara

Associate Professor

Bioinformatics

UNIVERSIDAD DE TALCA

Talca, Chile

ISAAC GARCÍA

Profesor Adjunto

Instituto de Neurociencias

Universidad de Valparaiso

Valparaiso, Chile

Horacio Poblete

Profesor Conferenciante

Universidad de Talca

Talca, Chile

Carlos Puebla

Profesor Asistente

Universidad de O'Higgins

Rancagua, Chile

Alan Neely

Pofesor

Instituto de Neurociencias

Universidad de Valparaíso

Valparaiso, Chile

Constantino Dragicevic

Claudio Cordova

Investigador asistente

Medicina

Universidad de Valparaíso

Valparaíso, Chile

Matías Zúñiga

Postdoctorado

Centro de Bioinformática y Simulación Molecular

Universidad de Talca

TALCA, Chile

VANESSA MARABOLI

Gestora de Proyectos

Vicerrectoría de Investigación y Doctorado

Universidad Andrés Bello

Santiago, Chile

Ingrid Carvacho

Assistant Professor

Medicina Traslacional

Universidad Católica del Maule

Talca, Chile

Magdalena Brahm

Geriatra

Instituto Nacional del Cáncer Dr. Caupolicán Pardo Correa

Santiago , Chile

Daniela De Giorgis

Estudiante de doctorado

Neurociencia

Universidad de Valparaíso

Valparaiso, Chile

Juan Castillo

lecturer

physics department

Universidad de Santiago de Chile

santiago, Chile

Romina Sepúlveda

Profesor Investigador

Facultad de Ciencias Biológicas

Universidad Andrés Bello

Santiago, Chile

ramon rogelio latorre de la cruz

Líneas de Investigación

Experiencia Profesional

Profesor Full Time

Formación de Capital Humano

Difusión y Transferencia

Premios y Distinciones

Elizabeth Cole Award

John Simon Guggenheim Memorial Foundation Fellowship

Third World Academy of Sciences Award in Biology

Miembro de la Academia de Ciencias de América Latina

Catédra Presidencial en Ciencias

Medalla Rectorial

Fellow of the Third World Academy of Sciences

Corresponding Member of the Brazilian Academy of Sciences

Foreigh Associate of the National Academy of the United States of America

Miembro de la Academia Chilena de Ciencias

Robert F Kennedy Professor in Latin American Studies

Visiting Scholar

Premio México en Ciencia y Tecnología

Dr Honoris Causa

Article (64)

Abstract (44)

BookSection (2)

BookWhole (3)

ConferencePaper (2)

EditorialMaterial (2)

Letter (1)

Proyecto (10)

GATING, ARCHITECTURE AND MODULATION BY BETA AND GAMMA SUBUNITS OF THE CALCIUM AND VOLTAGE-ACTIVATED POTASSIUM (BK) CHANNEL

STUDY OF STRUCTURAL AND DYNAMIC PROPERTIES THAT GOVERN SELECTIVITY AND CONDUCTANCE OF K CHANNELS UNDER NON-EQUILIBRIUM CONDITIONS.

DETERMINATION OF THE ARCHITECTURE AND DYNAMICS OF THE VOLTAGE- AND CALCIUM-ACTIVATED (BK) CHANNEL USING LANTHANIDE RESONANCE ENERGY TRANSFER (LRET)