Man

ramon rogelio latorre de la cruz

Profesor

Universidad de Valparaíso

5, Chile

Líneas de Investigación


Estructura y Función de los canales de iones; Reconstitución de canales de iones; Simulacion molecular; Proteinas de Membrana; Bioquimica Computacional; Bioinformática; Simulación Molecular; Nanobiotecnología

Experiencia Profesional

  •   Profesor Full Time

    Universidad de Chile

    Santiago, Chile

    1983 - 2000

Formación de Capital Humano


El Profesor ramon Latorre ha entrenado 30 doctores, 9 magister, 14 estudiantes de pregrado de diferentes carreras y 14 postdoctorantes


Difusión y Transferencia


El profesor Latorre junto con Claudio Bunster fundó el año 1983 el Centro Cientificode Santiago, con residenci luego en Valdivia
Creó el año 2008 Instituto Milenio Centro Interdisciplinario de Neurociencia de Valparaiso y a través de este Instituto y sus programas de outreach a diseminado la Ciencia y la Neurociencia en Chile.


Premios y Distinciones

  •   Elizabeth Cole Award

    Biophysical Society

    Estados Unidos, 1989

    Giver for: A significant advance in Biophysics which is accepted and used by others in the field

  •   John Simon Guggenheim Memorial Foundation Fellowship

    JOHN SIMON GUGGENHEIM MEMORIAL FOUNDATION

    Chile, 1990

    Granted through a proposal on Structure and function of Ion channels

  •   Third World Academy of Sciences Award in Biology

    THIRD WORLD ACADEMY OF SCIENCES

    Italia, 1991

    For Important Advances in the Field of Biophysics

  •   Miembro de la Academia de Ciencias de América Latina

    Academia de Ciencias de América Latina

    Venezuela, 1993

    Por su destacado papel en el campo de la biofísica y en la diseminación de la Ciemcia en América Latina

  •   Catédra Presidencial en Ciencias

    UNIVERSIDAD DE CHILE

    Chile, 1996

    Concurso competitivo. Proyecto: Estructura y Función de canales de potasio activados por calcio

  •   Medalla Rectorial

    UNIVERSIDAD DE CHILE

    Chile, 1996

    Por su papel en el desarrollo de la ciencia en la Universidad de Chile en particular y en Chile en general

  •   Fellow of the Third World Academy of Sciences

    THIRD WORLD ACADEMY OF SCIENCES

    Italia, 1997

    For his advances in the field of ion channels

  •   Corresponding Member of the Brazilian Academy of Sciences

    Academia de Ciencias de Brasil

    Brasil

    For his role of the development of Science in latin America

  •   Foreigh Associate of the National Academy of the United States of America

    NATIONAL ACADEMY OF SCIENCE

    Estados Unidos, 1999

    For his novel advances in the field of Biophysics

  •   Miembro de la Academia Chilena de Ciencias

    ACADEMIA CHILENA DE CIENCIAS

    Chile, 2002

    Por su papel en el desarrollo de la ciencia en Chile

  •   Robert F Kennedy Professor in Latin American Studies

    HARVARD UNIVERSITY

    Estados Unidos, 2003

    For his distinguish role in the development of science in Latin America

  •   Visiting Scholar

    UNIVERSITY OF CHICAGO

    Chile, 2007

    Given to distiguished scientists all over the world

  •   Premio México en Ciencia y Tecnología

    GOBIERNO DE MEXICO

    México, 2008

    Este premio otorgado a científicos de América Latina excepto México y España y Portuga fue concedido por el Presidente de méxico por la destacada carrera cientifica en el campo de la biofísca de canales de iones y su labor en la diseminación de la ciencia en América Latina

  •   Dr Honoris Causa

    UNIVERSIDAD DE LA REPUBLICA URUGUAY

    Uruguay, 2012

    Por sus contribuciones a la Ciencia y su papel de educado en América latina


 

Article (64)

A folding reaction at the C-terminal domain drives temperature sensing in TRPM8 channels
Dynamin-2 R465W mutation induces long range perturbation in highly ordered oligomeric structures
Loss-of-function BK channel mutation causes impaired mitochondria and progressive cerebellar ataxia
TRPV1-Estradiol Stereospecific Relationship Underlies Cell Survival in Oxidative Cell Death
Calcium-driven regulation of voltage-sensing domains in BK channels
The molecular nature of the 17 beta-Estradiol binding site in the voltage- and Ca2+-activated K+ (BK) channel beta 1 subunit
Zoledronic Acid Modulation of TRPV1 Channel Currents in Osteoblast Cell Line and Native Rat and Mouse Bone Marrow-Derived Osteoblasts: Cell Proliferation and Mineralization Effect
Demonstration of ion channel synthesis by isolated squid giant axon provides functional evidence for localized axonal membrane protein translation.
Determination of the Stoichiometry between α- and γ1 Subunits of the BK Channel Using LRET.
Gating charge displacement in a monomeric voltage-gated proton (Hv1) cannel
The syndromic deafness mutation G12R impairs fast and slow gating in Cx26 hemichannels
Thermally activated TRP channels=> molecular sensors for temperature detection.
Calcium binding and voltage gating in Cx46 hemichannels.
Molecular Determinants of BK Channel Functional Diversity and Functioning
The enduring legacy of the "constant-field equation" in membrane ion transport.
?1-subunit-induced structural rearrangements of the Ca2+- and voltage-activated K+ (BK) channel
Allosterism and Structure in Thermally Activated Transient Receptor Potential Channels.
Charged Residues at the First Transmembrane Region Contribute to the Voltage Dependence of the Slow Gate of Connexins.
Structure-Driven Pharmacology of Transient Receptor Potential Channel Vanilloid 1
Hydrophobic interaction between contiguous residues in the S6 transmembrane segment acts as a stimuli integration node in the BK channel
Mechanism of potassium ion uptake by the Na+/K+-ATPase
Molecular Determinants of Phosphatidylinositol 4,5-Bisphosphate (PI(4,5)P-2) Binding to Transient Receptor Potential V1 (TRPV1) Channels
Molecular mechanism underlying beta 1 regulation in voltage- and calcium-activated potassium (BK) channels
Voltage-gated proton (H(v)1) channels, a singular voltage sensing domain
Directionality of Temperature Activation in Mouse TRPA1 Ion Channel Can Be Inverted by Single-Point Mutations in Ankyrin Repeat Six
Gating of Thermally Activated Channels
Temperature and Voltage Coupling to Channel Opening in Transient Receptor Potential Melastatin 8 (TRPM8)
The Pore-Domain of TRPA1 Mediates the Inhibitory Effect of the Antagonist 6-Methyl-5-(2-(trifluoromethyl)phenyl)-1H-indazole
A BK (Slo1) channel journey from molecule to physiology
De novo expression of connexin hemichannels in denervated fast skeletal muscles leads to atrophy
Emerging Role of Calcium-Activated Potassium Channel in the Regulation of Cell Viability Following Potassium Ions Challenge in HEK293 Cells and Pharmacological Modulation
K+ Channels: Function-Structural Overview
Modulation of BK channel voltage gating by different auxiliary beta subunits
Splicing of the rSlo gene affects the molecular composition and drug response of Ca 2+-activated K + channels in skeletal muscle
Splicing of the rSlo Gene Affects the Molecular Composition and Drug Response of Ca2+-Activated K+ Channels in Skeletal Muscle
The first transmembrane domain (TM1) of beta 2-subunit binds to the transmembrane domain S1 of alpha-subunit in BK potassium channels
Energy landscape of the reactions governing the Na+ deeply occluded state of the Na+/K+-ATPase in the giant axon of the Humboldt squid
Thermo-TRP Channels: Biophysics of Polymodal Receptors
Allosteric interactions and the modular nature of the voltage- and Ca2+-activated (BK) channel
Cell volume and membrane stretch independently control K+ channel activity
TRANSPLANTABLE SITES CONFER TEMPERATURE AND PIP2 SENSITIVITY TO THERMO TRANSIENT RECEPTOR POTENTIAL (TRP) CHANNELS
Intrinsic electrostatic potential in the BK channel pore: Role in determining single channel conductance and block
Dissection of the components for PIP(2) activation and thermosensation in TRP channels
Thermo TRP channels as modular proteins with allosteric gating
A hot-sensing cold receptor: C-terminal domain determines thermosensation in transient receptor potential channels
Ciencia: unidad en la variedad
Structural determinants for functional coupling between the beta and alpha subunits in the Ca2+-activated K+ (BK) channel
Differential effects of beta 1 and beta 2 subunits on BK channel activity
S3b amino acid residues do not shuttle across the bilayer in voltage-dependent Shaker K+ channels
Clues to understanding cold sensation: Thermodynamics and electrophysiological analysis of the cold receptor TRPM8
Gain-of-function mutation in the KCNMB1 potassium channel subunit is associated with low prevalence of diastolic hypertension
Anion permeation in human CIC-4 channels
Molecular coupling between voltage sensor and pore opening in the Arabidopsis inward rectifier K+ channel KAT1
Structure and function of potassium channels in plants: some inferences about the molecular origin of inward rectification in KAT1 channels (Review)
Ca2+-activated K+ channel inhibition by reactive oxygen species
Counting channels: A tutorial guide on ion channel fluctuation analysis
New disguises for an old channel: MaxiK channel ?-subunits
New disguises for an old channel: MaxiK channel beta-subunits
A conducting state with properties of a slow inactivated state in a Shaker K+ channel mutant
Actin modifies Ca2+ block of epithelial Na+ channels in planar lipid bilayers
Periodic perturbations in Shaker K+ channel gating kinetics by deletions in the S3-S4 linker
Apical sorting of a voltage- and Ca2+-activated K+ channel alpha-subunit in Madin-Darby canine kidney cells is independent of N-glycosylation
Deletion of the S3-S4 linker in the Shaker potassium channel reveals two quenching groups near the outside of S4
Modulation of the Shaker K+ channel gating kinetics by the S3-S4 linker

Abstract (44)

Effects of the Accessory Subunit gamma 1 on the External Architecture of BK Channel
Proton Permeation in Ci-Hv1 Voltage-Gated Proton Channels occurs through a Proton Wire Involving Residues D160 and D222 and It is Modulated by N264
Rational discovery of new capsaicin analogues as TRPV1 activators
Residues Involved in Cx26 Hemichannels Voltage Dependent Gating
Temperature and Voltage Coupling to TRPM8 Channel Opening
The Molecular Determinants of PI(4,5)P-2 Binding to TRPV1 Channels
The Role of the Ion Dehydration Process in Low and High Conductance K Channels
Gating Currents of Monomeric Hv Channel Reveals a Permeation Pathway Coupled to the Voltage Activation
K+ Translocation by the Giant Axon of the Humboldt Squid Na+/K ATPase
Single-Point Mutations in Ankyrin Repeat Six Make Mouse TRPA1 Sensitive to Hot Temperatures
Single-Point Mutations in Ankyrin Repeat Six Make Mouse TRPA1 Sensitive to Warm Temperatures
Substitutions at F380 in S6 by Small Hydrophobic Amino Acids Makes the Opening Transition in BK Channels Rate Limiting
The Permeation Pathway Mechanism in Ciona Intestinalis Hv Channel
Bendroflumethiazide a potent opener of human BK channel : a new perspective for an old drug in the treatment of periodic paralysis
External Architecture of the Large-Conductance Ca2+ and Voltage-Activated K+ (BKCa) Revealed by a Spectroscopic Ruler
Voltage-Dependence in Thermo-Voltage Sensitive Channel TRPV1. A Delocalized Voltage Sensor?
Differential Effects of Beta Subunits on the Voltage Sensor of Ca2+ and Voltage-Activated K+ Channels
Energetics of the Reactions Controlling the Deeply Occluded State of the Na+/K+ Pump
The C Terminus is Responsible of the Thermo Sensitivity in TRPM8 Channels
A Molecular Model for the Bkca Channel and the Location of B1 in the B1/A Subunit Complex
beta-Subunit transmembrane domains are required for functional coupling with alpha-subunit in BK channel
Dissecting phosphatidylinositol 4,5-bisphosphate activation and thermosensation in TRP channels
Effects of Acetazolamide on alpha subunit of human BK channel expressed in HEK293 cells
External surface charge neutralization induces outward rectification on the calcium- and voltage-activated potassium channel BK
Determinant for temperature sensing in transient receptor potential channels
Biophysical characterization of the cold receptor CMR1
Exploring the Shaker K+ channel S3b segment using deletion mutants.
Lack of transmembrane movement of Shaker K+ channel S3b
Role of the electrostatic potential on the BK potassium channel conductance.
Displacement of S3 segment during activation of Shaker K+ channel with a short S3-S4 linker
Molecular basis of BK modulation by beta subunits and channel activation by estrogens.
The moving parts of the KAT1 K+ channel
Domains of beta subunit involved in modulation of MaxiK channel modulation
Effects of partial deletions of S3 segment in Shaker K+ channel activation kinetics
MaxiK channel activation by estradiol and tamoxifen: Role of the extracellular domain of the beta 1-subunit
Inhibition of a Ca2+-activated K(+)channel by H2O2
Kat1, a K+ channel from Arabidopsis thaliana, possesses an intrinsic voltage sensor.
Periodic perturbations in Shaker K+ channel gating kinectics by deletions in the S3-S4 linker.
A conducting slow inactivated Shaker channel?
Deletions in the S3-S4 linker modify Shaker K+ channel gating kinetics
Inhibition of Ca2+-dependent K+ channel currents by exposure to hydrogen peroxide
Localisation of ion binding sites and modulation by oestrogens in a Ca2+-dependent K+ (MaxiK) channel
Modulations of the Shaker K+ channel activation kinetics by the S3-S4 linker
The inward rectifier K+ channel, Kat1, from Arabidopsis thaliana possesses an intrinsic voltage sensor

BookSection (2)

Voltage-Dependent K+ Channels
Mutagenesis and Temperature-Sensitive Little Machines

BookWhole (3)

Methods for Investigating TRP Channel Gating
Biophysical and molecular features of thermosensitive TRP channels involved in sensory transduction
Signal transduction-dependent channels

ConferencePaper (2)

Allosteric interactions and the modular nature of the voltage- and Ca 2+-activated (BK) channel
Helical nature of the voltage sensor

EditorialMaterial (2)

Keeping you healthy: BK channel activation by omega-3 fatty acids
Perspectives on TRP Channel Structure and the TRPA1 Puzzle

Letter (1)

Save the lab in Montemar, Chile

Proyecto (10)

GATING, ARCHITECTURE AND MODULATION BY BETA AND GAMMA SUBUNITS OF THE CALCIUM AND VOLTAGE-ACTIVATED POTASSIUM (BK) CHANNEL
STUDY OF STRUCTURAL AND DYNAMIC PROPERTIES THAT GOVERN SELECTIVITY AND CONDUCTANCE OF K CHANNELS UNDER NON-EQUILIBRIUM CONDITIONS.
DETERMINATION OF THE ARCHITECTURE AND DYNAMICS OF THE VOLTAGE- AND CALCIUM-ACTIVATED (BK) CHANNEL USING LANTHANIDE RESONANCE ENERGY TRANSFER (LRET)
IONIC CONDUCTION IN K CHANNELS
BASES MOLECULARES DE LA SENSIBILIDAD TERMICA EN MAMIFEROS.
MECANISMOS ALOSTERICO EN LA ACTIVACION DEL CANAL TRPM8.
ASPECTOS MOLECULARES QUE GOBIERNAN LA CONDUCTANCIA DE LOS CANALES DE POTASIO.
MECANISMO MOLECULAR DEL ACOPLAMIENTO ENTRE UN CANAL DE K+ ACTIVADO POR CA2+ (BKca) Y SUS SUBUNIDADES MODULADORES B.
DETERMINANTES MOLECULARES QUE MEDIAN LA ACTIVACION DEL CANAL DE LA PLANTA ARABIDOPSIS THALIANA KAT1
COMPONENTES MOLECULARES QUE MEDIAN ENTRE LA UNION DE CALCIO Y LA APERTURA DE UN CANAL DE POTASIO ACTIVADO POR CALCIO

Review (8)

Pharmacological consequences of the coexpression of BK channel alpha and auxiliary beta subunits
Proton channel models Filling the gap between experimental data and the structural rationale
Voltage sensor of ion channels and enzymes
A Cool Channel in Cold Transduction
Acute and fulminant hepatitis induced by flutamide: Case series report and review of the literature
Structure-functional intimacies of transient receptor potential channels
A marriage of convenience: beta-subunits and voltage-dependent K+ channels
Large conductance Ca2+-activated K+ (BK) channel: Activation by Ca2+ and voltage
125
ramon latorre

Profesor

Instituto de Neurociencia

Universidad de Valparaíso

5, Chile

17
Fernando Gonzalez

Titular Professor

Facultad de Ciencias de la Vida

Universidad Andres Bello

Santiago, Chile

11
Patricio Orio

Profesor Titular

UNIVERSIDAD DE VALPARAÍSO

Valparaíso, Chile

10
Sebastian Brauchi

Associate Professor

Physiology

Universidad Austral de Chile

Valdivia, Chile

8
Patricio Rojas

Assistant Professor

Departamento de Biologia

UNIVERSIDAD DE SANTIAGO DE CHILE

Santiago, Chile

8
Daniel Aguayo

Assistant Professor

Molecular Biophysics & Bioinformatics Group

UNIVERSIDAD ANDRES BELLO

Santiago, Chile

8
Alan Neely

Pofesor

Instituto de Neurociencias

Universidad de Valparaíso

Valparaiso, Estados Unidos

6
Karen Castillo

Investigadora

Laboratorio de Sensores Moleculares, Centro Interdisciplinario de Neurociencia de Valparaíso (CINV), Facultad de Ciencias, Universidad de Valparaíso

Valparaiso, Chile

6
Wendy Gonzalez

Director of the Center for Bioinformatics, Simulations and Modeling (CBSM)

Bioinformática

CENTRO DE BIOINFORMÁTICA Y SIMULACIÓN MOLECULAR (CBSM)/ UNIVERSIDAD DE TALCA

Talca, Chile

5
Diego Cosmelli

Profesor Asociado y Sub-director de Investigación y Postgrado

Escuela de Psicología

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

Santiago, Chile

5
GUSTAVO CONTRERAS

Centro Interdisciplinario de Neurociencias de Valparaíso

Valparaiso, Chile

4
Francisco Morera

Assistant Professor

Pharmacology

UNIVERSIDAD AUSTRAL DE CHILE

Valdivia, Chile

4
Agustin Martinez

Profesor Titular

Instituto de Neurociencia

UNIVERSIDAD DE VALPARAÍSO, CENTRO INTERDISCIPLINARIO DE NEUROCIENCIAS DE VALPARAÍSO

Valparaíso, Chile

4
Cecilia Vergara

Profesor Asociado

Biología

DEPARTAMENTO BIOLOGIA, FACULTAD DE CIENCIAS, U. DE CHILE

Santiago, Chile

3
Juan Saez

Professor

Instituto de Neurociencias

Universidad de Valparaiso

Valparaíso, Chile

3
Ingrid Carvacho

Profesora Auxiliar/Directora de Investigación

Biología y Química

Universidad Católica del Maule

Talca, Chile

2
Horacio Poblete

Profesor Conferenciante

Universidad de Talca

Talca, Chile

2
Carolina Mascayano

Académico

Ciencias del Ambiente

UNIVERSIDAD DE SANTIAGO DE CHILE, FACULTAD DE QUÍMICA Y BIOLOGIA

santiago, Chile

2
Daniela De Giorgis

Estudiante de doctorado

Neurociencia

Universidad de Valparaíso

Valparaiso, Chile

2
David Naranjo

Profesor titular

Neurociencia

Universidad de Valparaíso

VALPARAISO, Chile

2
Pablo Olivero

Profesor Adjunto

Patologia y Fisiologia

Universidad de Valparaiso

Viña del Mar, Chile

1
ISAAC GARCÍA

Profesor Adjunto

Instituto de Neurociencias

Universidad de Valparaiso

Valparaiso, Chile

1
Luis Cea

Profesor programa teaching

Instituto de Ciencias Biomédicas

Universidad Autónoma de Chile

Santiago, Chile

1
Carlos Puebla

Assistant Professor

Universidad de O'Higgins

Santiago, Chile

1
Xavier Figueroa

Associate Professor

Departamento de Fisiologia

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

1
Ariela Vergara

Assistant Professor

Bioinformatics

UNIVERSIDAD DE TALCA

Talca, Chile

1
Tomas Perez-Acle

Full Professor

Computational Biology Lab

Fundación Ciencia para la Vida

Santiago, Chile

1
Carlos Puebla

Profesor Asistente

Universidad de O'Higgins

Rancagua, Chile

1
Luis González

Full Professor

School of Medicine

Universidad San Sebastián

Santiago, Chile

1
Matías Zúñiga

Postdoctorado

Centro de Bioinformática y Simulación Molecular

Universidad de Talca

TALCA, Chile

1
VANESSA MARABOLI

Ingeniera Bioinformática

Facultad de Ciencias de la Vida

Universidad Andrés Bello

Santiago, Chile