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Ivanny Carolina Marchant Ramirez

Directora Unidad de Estudios Clínicos

ESCUELA DE MEDICINA UNIVERSIDAD DE VALPARAISO

Valparaiso, Chile

Human physiology underlying human pharmacokinetics and pharmacodynamics. Cardiovascular disease; Clinical pharmacology; Pathophysiology of arterial hypertension and cardiovascular risk. Translational applied strategies.

Farmacología clínica, UNIVERSITE CLAUDE BERNARD LYON I. Francia, 2009
Médico-cirujano, UNIVERSIDAD DE VALPARAISO. Chile, 2001
Farmacología clínica, UNIVERSIDAD COMPLUTENSE DE MADRID. España, 2005

Profesor titular Full Time

UNIVERSIDAD DE VALPARAISO

Medicina

Valparaíso, Chile

2003 - A la fecha

Médico Servicio Medicina interna Part Time

Hospital de Quilpué

Quilpué, Chile

2002 - 2002
médico general Other

Sociedad profesional de urgencia cardiológica EMECAR

Viña del Mar, Chile

2002 - 2003

Charcot

MINISTERIO ASUNTOS EXTERIORES Y COOPERACION

Francia, 2005

De excelencia en el dominio médico


Diabetes, periodontitis, and cardiovascular disease: towards equity in diabetes care Seron, Constanza; Olivero, Pablo; Flores, Nicolas; Cruzat, Benjamin; Ahumada, Francisca; Gueyffier, F.; Marchant, Ivanny Article ISI SCOPUS Frontiers in Public Health (2023)
HER2 classification in breast cancer cells: A new explainable machine learning application for immunohistochemistry Cordova, Claudio; Munoz, Roberto; Olivares, Rodrigo; Minonzio, Jean-Gabriel; Lozano, Carlo; Gonzalez, Paulina; Marchant, Ivanny; Gonzalez-Arriagada, Wilfredo; Olivero, Pablo Article ISI ONCOLOGY LETTERS (2023)
Estrogen, Cognitive Performance, and Functional Imaging Studies: What Are We Missing About Neuroprotection? Marchant, Ivanny Carolina; Chabert, Steren; Martinez-Pinto, Jonathan; Sotomayor-Zarate, Ramon; Ramirez-Barrantes, Ricardo; Acevedo, Lilian; Cordova, Claudio; Olivero, Pablo Article ISI FRONTIERS IN CELLULAR NEUROSCIENCE (2022)
Optogenetic control of cancer cell survival in ChR2-transfected HeLa cells Cordova, Claudio; Lozano, Carlo; Rodriguez, Belen; Marchant, Ivanny; Zuniga, Rodrigo; Ochova, Paola; Olivero, Pablo; Gonzalez-Arriagada, Wilfredo Alejandro Article ISI INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY (2021)
TRPV1-Estradiol Stereospecific Relationship Underlies Cell Survival in Oxidative Cell Death Ramirez-Barrantes, Ricardo; Carvajal-Zamorano, Karina; Rodriguez, Belen; Cordova, Claudio; Lozano, Carlo; Simon, Felipe; Diaz, Paula; Munoz, Pablo; Marchant, Ivanny; Latorre, Ramon; Castillo, Karen; Olivero, Pablo Article ISI FRONTIERS IN PHYSIOLOGY (2020)
Intracellular aggregated TRPV1 is associated with lower survival in breast cancer patients Lozano, Carlo; Cordova,Claudio; Marchant, Ivanny; Zuniga, Rodrigo; Ochova, Paola; Ramirez-Barrantes, Ricardo; Alejandro Gonzalez-Arriagada, Wilfredo; Rodriguez, Belen; Olivero, Pablo Article WOS-ESCI BREAST CANCER-TARGETS AND THERAPY (2018)
Proteostasis and Mitochondrial Role on Psychiatric and Neurodegenerative Disorders: Current Perspectives Olivero, Pablo; Lozano, Carlo; Sotomayor-Zarate, Ramon; Meza-Concha, Nicolas; Arancibia, Marcelo; Cordova,Claudio; Gonzalez-Arriagada, Wilfredo; Ramirez-Barrantes, Ricardo; Marchant, Ivanny Article ISI SCOPUS NEURAL PLASTICITY (2018)
Transient Receptor Potential Vanilloid 1 Expression Mediates Capsaicin-Induced Cell Death Ramirez-Barrantes, Ricardo; Cordova,Claudio; Gatica, Sebastian; Rodriguez, Belen; Lozano, Carlo; Marchant, Ivanny; Echeverria, Cesar; Simon, Felipe; Olivero, Pablo Article ISI SCOPUS FRONTIERS IN PHYSIOLOGY (2018)
A sudden death risk score specifically for hypertension: based on 25648 individual patient data from six randomized controlled trials Le, HH; Subtil, F; Cerou, M; Marchant, I; Al-Gobari, M; Fall, M; Mimouni, Y; Kassai, B; Lindholm, L; Thijs, L; Gueyffier, F Article ISI SCOPUS Journal of Hypertension (2017)
[OP.1D.08] SYNERGETIC PREVENTION OF SUDDEN DEATH BY ACEI, STATIN AND GLIFLOZIN IN TYPE 2 DIABETES: A SIMULATION STUDY Le, Hai Ha; Marchant, Ivanny; Boissel, Jean-Pierre; Nony, Patrice; Kassaï, Behrouz; Cornu, Catherine; Gueyffier, Francois Article Journal of Hypertension, Supplement (2016)
Impact of Aldosterone Antagonists on Sudden Cardiac Death Prevention in Heart Failure and Post-Myocardial Infarction Patients: A Systematic Review and Meta-Analysis of Randomized Controlled Trials Le, HH; El-Khatib, C; Mombled, M; Guitarian, F; Al-Gobari, M; Fall, M; Janiaud, P; Marchant I.; Cucherat, M; Bejan-Angoulvant, T; Gueyffier, F. Article ISI SCOPUS PLOS ONE (2016)
Perspectives of TRPV1 Function on the Neurogenesis and Neural Plasticity. Ramírez-Barrantes R, Cordova C, Poblete H, Muñoz P, Marchant I, Wianny F, Olivero P Article Neural Plasticity (2016)
TRPV1 may increase the effectiveness of estrogen therapy on neuroprotection and neuroregeneration Ramírez-Barrantes, Ricardo; Marchant, Ivanny; Olivero, Pablo Article Neural Regeneration Research (2016)
High Risk versus Proportional Benefit: Modelling Equitable Strategies in Cardiovascular Prevention Marchant I.; Boissel, JP; Nony, P; Gueyffier, F. Article ISI SCOPUS PLOS ONE (2015)
Biomarqueur, critère intermédiaire et critère de substitution. Gueyffier F, Marchant I Article La Lettre du Pharmacologue (2014)
Comparison of an effect-model-law-based method versus traditional clinical practice guidelines for optimal treatment decision-making: application to statin treatment in the French population Kahoul, R; Gueyffier, F.; Amsallem, E; Haugh, M; Marchant I.; Boissel, FH; Boissel, JP Article ISI SCOPUS JOURNAL OF THE ROYAL SOCIETY INTERFACE (2014)
Comparison of an effect-model-law-based method versus traditional clinical practice guidelines for optimal treatment decision-making: application to statin treatment in the French population. Kahoul R, Gueyffier F, Amsallem E, Haugh M, Marchant I, Boissel FH, Boissel JP Article Journal of The Royal Society Interface (2014)
Improving risk prediction performance for a better guidelines application Marchant I, Bejan-Angoulvant T, Le HH, Gueyffier F. Article Journal of Hypertension (2014)
The missed HDL-cholesterol objective, or the failure of CETP inhibitors. Gueyffier F, Marchant I, Henin E, Hourcade-Potelleret F. Article La Lettre du Pharmacologue (2014)
Modeling the impact of cardiovascular prevention strategies: toward better information for public health decisions Gueyffier I, Marchant I, Carlberg B Article J Hypertens (2012)
Virtual Patients and Sensitivity Analysis of the Guyton Model of Blood Pressure Regulation: Towards Individualized Models of Whole-Body Physiology Moss, R; Grosse T.; Marchant I.; Lassau N.; Gueyffier, F.; Thomas S.R. Article ISI SCOPUS PLoS Computational Biology (2012)
Virtual patients and sensitivity analysis of the Guyton model of blood pressure regulation: towards individualized models of whole-body physiology. Moss R, Grosse T, Marchant I, Lassau N, Gueyffier F, Thomas SR Article PLoS Comput Biol (2012)
The Global Risk Approach should be better applied in French Hypertensive Patients: A Comparison between Simulation and Observation Studies Marchant I, Nony P, Cucherat M, Boissel JP, Thomas SR, Bejan-Angoulvant T, Laugerotte A, Kahoul R, Gueyffier F Article PLoS One (2011)
The Global Risk Approach Should Be Better Applied in French Hypertensive Patients: A Comparison between Simulation and Observation Studies Marchant I.; Nony, P; Cucherat, M; Boissel, JP; Thomas, SR; Bejan-Angoulvant, T; Laugerotte A.; Kahoul, R; Gueyffier, F. Article ISI SCOPUS PLOS ONE (2011)
Administration of neurotoxic doses of MDMA reduces sensitivity to ethanol and increases GAT-1 immunoreactivity in mice striatum Izco M, Gutierrez-Lopez MD, Marchant I, O'Shea E, Colado MI Article Psychopharmacology (2010)
Administration of neurotoxic doses of MDMA reduces sensitivity to ethanol and increases GAT-1 immunoreactivity in mice striatum Izco M.; Gutierrez-Lopez M.D.; Marchant I.; O'Shea E.; Colado M.I. Article SCOPUS Psychopharmacology (2010)
Blood pressure lowering in the oldest old: a step toward abandoning arbitrary blood pressure targets Gueyffier F, Perez MI, Wright JM, Marchant I, Musini VM, Bejan-Angoulvant T Article J Hypertens (2010)
SCORE should be preferred to Framingham to predict cardiovascular death in French population Marchant I, Boissel JP, Kassai B, Bejan T, Massol J, Vidal C, Amsallem E, Naudin F, Galan P, Czernichow S, Nony P, Gueyffier F Article Eur J Cardiovasc Prev Rehabil (2009)
"Mice with decreased cerebral dopamine function following a neurotoxic dose of MDMA (3,4-methylenedioxymethamphetamine, "ecstasy") exhibit increased ethanol consumption and preference" Izco M.; Marchant I.; Escobedo I.; Peraile I.; O'Shea E.; Colado M.I.; Delgado M.; Higuera-Matas A.; Olias O.; Ambrosio E. Article SCOPUS JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2007)


US cholesterol guidelines do not fit French population Gafsi, J; Marchant I.; Gueyffier, F. Abstract ISI FUNDAMENTAL CLINICAL PHARMACOLOGY (2018)
DOES DIABETES REALLY HARM WOMEN MORE THAN MEN? ANALYSES FROM 30560 INDIVIDUAL PATIENT DATA Le, H; Subtil, F; Cerou, M; Marchant I.; Lindholm, L; Thijs, L; Gueyffier, F. Abstract ISI (2017)
PUBLIC HEALTH IMPACT OF CARDIOVASCULAR TREATMENTS IN PRIMARY PREVENTION: A SIMULATION STUDY ON A VIRTUAL REALISTIC POPULATION Fall, M; Le, H; Marchant I.; Gueyffier, F. Abstract ISI (2017)
VALIDATION OF FRAMINGHAM AND SCORE IN 30560 PATIENTS WITH HYPERTENSION Le, H; Marchant I.; Subtil, F; Boissel, J; Gueyffier, F. Abstract ISI (2017)
Virtual realistic population: a new tool to illustrate the impact of both drug combination & risk - based patient selection strategies Le, HH; Marchant I.; Boissel, JP; Nony, P; Kassai, B; Cornu, C; Gueyffier, F. Abstract ISI FUNDAMENTAL CLINICAL PHARMACOLOGY (2015)
TOWARDS EQUITABLE STRATEGIES FOR HYPERTENSION MANAGEMENT IN CARDIOVASCULAR PREVENTION Marchant I.; Gueyffier, F. Abstract ISI Basic & clinical pharmacology & toxicology (2011)


Improving risk prediction performance for a better guidelines application Marchant I.; Bejan-Angoulvant, T; Le, HH; Gueyffier, F. EditorialMaterial ISI SCOPUS JOURNAL OF HYPERTENSION (2014)
Modeling the impact of cardiovascular prevention strategies: toward better information for public health decisions Gueyffier, F.; Marchant I.; Carlberg B. EditorialMaterial ISI SCOPUS Journal of Hypertension (2012)


Blood pressure lowering in the oldest old: a step toward abandoning arbitrary blood pressure targets Gueyffier, F.; Perez, MI; Wright, JM; Marchant I.; Musini, VM; Bejan-Angoulvant, T Letter ISI SCOPUS Journal of Hypertension (2011)


Desarrollo de una plataforma interdisciplinaria para la innovación en salud=> un referente internacional en el desarrollo de medicina de precisión. MINEDUC Convenio de Desempeño Apoyo a la Innovación en Educación Superior PMI (UVA1402) Proyecto 2015-2018 Investigador(a)
Biomarkers and cell replacement therapy at early Parkinson's disease=> from human electrophysiology to cell grafting in a non-human primate model PCI (C12S02) Proyecto 2012-2015 Coinvestigador(a)
Evaluation of the exposure to mining environmental liabilities on neighboring villages through determination of heavy metals and arsenic speciation on drinking water and top soil FONIS (SA11I2265) Proyecto 2011-2013 Coinvestigador(a)
Optimising cardiovascular prevention strategies in the Chilean population from their predicted public health impact FONDECYT (11110399) Proyecto 2011-2014 Inv. Responsable
Building the public health Impact Model for Blood pressure lowering drugs => from gene to pOpulation- BIMBO Agence Nationale de la Recherche - ANR France (SYSCOMM 002) Proyecto 2008-2012 Investigador(a)


Perspectives of TRPV1 Function on the Neurogenesis and Neural Plasticity Ramirez-Barrantes, R; Cordova, C; Poblete, H.; Muñoz P; Marchant I.; Wianny, F; Olivero P. Review ISI SCOPUS NEURAL PLASTICITY (2016)
TRPV1 may increase the effectiveness of estrogen therapy on neuroprotection and neuroregeneration Ramirez-Barrantes, R ; Marchant, I; Olivero, P Review ISI SCOPUS NEURAL REGENERATION RESEARCH (2016)