Captura_de_pantalla_2021-03-08_a_la(s)_13.24.41.png_thumb90

Pablo César Muñoz Carvajal

UNIVERSIDAD DE VALPARAÍSO

Valparaíso, Chile

Líneas de Investigación


Synaptic plasticity; Aging; Redox signaling

Educación

  •  Doctor en ciencias, UNIVERSIDAD DE CHILE. Chile, 2007
  •  Bioquímico, UNIVERSIDAD DE SANTIAGO DE CHILE. Chile, 2000

 

Article (32)

Lack of Pannexin 1 Alters Synaptic GluN2 Subunit Composition and Spatial Reversal Learning in Mice
Ryanodine receptor-mediated calcium release has a key role in hippocampal LTD induction
Aging Impairs Hippocampal- Dependent Recognition Memory and LTP and Prevents the Associated RyR Up-regulation
Astaxanthin protects primary hippocampal neurons against noxious effects of ABeta-oligomers
Astaxanthin protects primary hippocampal neurons against noxious effects of A ?-oligomers
Connecting Synaptic Activity with Plasticity-Related Gene Expression: From Molecular Mechanisms to Neurological Disorders.
Inhibition of DNA Methylation Impairs Synaptic Plasticity during an Early Time Window in Rats.
Perspectives of TRPV1 function on the neurogenesis and neural plasticity.
Synaptic impairment in layer 1 of the prefrontal cortex induced by repeated stress during adolescence is reversed in adulthood
Effects of chronic stress in adolescence on learned fear, anxiety, and synaptic transmission in the rat prelimbic cortex
Effects of chronic stress in adolescence on learned fear, anxiety, and synaptic transmission in the rat prelimbic cortex.
Pannexin 1 Regulates Bidirectional Hippocampal Synaptic Plasticity in Adult Mice,
Prenatal Stress Caused by Movement Restriction Induces Changes in the Appendicular Osseous Development of CF-1 Mice Progeny.
Iron deficiency on neuronal function
Iron deficiency on neuronal function.
Iron Mediates N-Methyl-D-aspartate Receptor-dependent Stimulation of Calcium-induced Pathways and hippocampal synaptic plasticity.
Iron- mediated redox modulation in neural plasticity.
Prenatal stress caused by movement restriction induces changes in the appendicular osseous development of CF-1 mice progeny [El Estrés Prenatal Causado por Restricción de Movimiento Induce Cambios en el Desarrollo Óseo Apendicular de la Progenie de Ratones CF-1]
Recent rodent models for Alzheimer's disease: clinical implications and basic research.
Iron Mediates N-Methyl-D-aspartate Receptor-dependent Stimulation of Calcium-induced Pathways and Hippocampal Synaptic Plasticity
Role of DNA methylation during recognition memory in hippocampus and perirhinal cortex in rats.
Impaired cognition, sensorimotor gating, and hippocampal long-term depression in mice lacking the prostaglandin E2 EP2 receptor.
Impaired cognition, sensorimotor gating, and hippocampal long-term depression in mice lacking the prostaglandin E2 EP2 receptor
Potential adaptative function for altered long- term potentiation mechanism in aging hippocampus.
Potential adaptive function for altered long-term potentiation mechanisms in aging hippocampus
A role for reactive oxygen/nitrogen species and iron on neuronal synaptic plasticity
Calcium release by ryanodine receptors mediates hydrogen peroxide-induced activation of ERK and CREB phosphorylation in N2a cells and hippocampal neurons
Calcium release by ryanodine receptors mediates hydrogen peroxide-induced activation of ERK and CREB phosphorylation in N2a cells and hippocampal neurons.
Effect of iron on the activation of the MAPK/ERK pathway in PC12 neuroblastoma cells
Effect of iron on the activation of the MAPK/ERK pathway in PC12 neuroblastoma cells.
Iron and glutathione at the crossroad of redox metabolism in neurons
Iron and glutathione at the crossroad of redox metabolism in neurons.

Abstract (3)

A role for iron, calcium and reactive oxygen species on hippocampal synaptic plasticity
Physiology and pathology of iron in neuronal function
Calcium release mediated by redox activation of ryanodine receptors induces CREB and ERK phosphorylation in N2a cells and hippocampal neurons

Editorial (1)

Connecting synaptic activity with plasticity-related gene expression: From molecular mechanisms to neurological disorders

Proyecto (16)

Center for Biomedical Research (CIB)
Unveiling how neuronal calcium signals reach the nucleus following synapse activation
Efecto de la terapia led transcraneana (TLTC) aplicada sobre las capacidades coginitivas en ratón modelo de la enfermedad Alzheimer.
HIPPOCAMPAL RYANODINE RECEPTORS-CALCIUM RELEASE CHANNELS MEDIATE ACTIVITY-GENERATED POSTSYNAPTIC CALCIUM SIGNALS AND THEIR PROPAGATION TO THE NUCLEUS
“Desarrollo de una plataforma interdisciplinaria para la innovación en salud=> referente internacional en el desarrollo de medicina de precision”.
The high ROS content of aged rats alters RyR-mediated calcium-signaling, impairing hippocampal synaptic plasticity and spatial memory
Mechanism of plasma membrane permeabilization induced by syndromic deafness mutations of Cx26
Obtención de astaxantina como agente anti-envejecimiento cerebral, a partir del descarte de la centolla
Nanopartícula de quitosano contenedora de un quelante de hierro como agente neuroprotector
Formulación de nanofibras de quitosano contenedoras de compuestos antioxidantes para su potencial uso en neuroprotección
Iniciativa Científica Milenio (ICM) IC09-022-P. Instituto Milenio “Centro Interdisciplinario de Neurociencia de Valparaíso
Creación de Centros Regionales de Desarrollo Científico y Tecnológico
Diseño, producción y evaluación de Jugos de Uvas con propiedades funcionales que contribuyan a la promoción de la salud de la población
Senile Degeneration in the Brain of Octogon Degus
Estado oxidativo neuronal regula la metilación del DNA en promotores de genes importantes para la plasticidad sináptica, la memoria y la enfermedad de Alzheimer
Synaptic Plasticity and aging

Review (3)

Perspectives of TRPV1 Function on the Neurogenesis and Neural Plasticity
Recent rodent models for Alzheimer's disease: clinical implications and basic research
A role for reactive oxygen/nitrogen species and iron on neuronal synaptic plasticity
18
Pablo Muñoz

UNIVERSIDAD DE VALPARAÍSO

Valparaíso, Chile

8
M. Cecilia Hidalgo

Professor

ICBM

Universidad de Chile

Santiago, Chile

5
Marco Nuñez

Professor

Biology

Fac. Ciencias, Universidad de Chile

Santiago, Chile

3
Pabla Aguirre

Asistente de investigación

Biología

Universidad de Chile

Santiago, Chile

2
Gina Sanchez

Profesor Asociado

ICBM

UNIVERSIDAD DE CHILE, FAC MEDICINA , ICBM

Santiago, Chile

2
Ulrike Kemmerling

Full Professor

ICBM

Facultad de Medicina, Universidad de Chile

Santiago, Chile

2
ALEXIS HUMERES

DIRECTOR

MORFOFUNCIÓN

Universidad Diego Portales

SANTIAGO, Chile

1
Tatiana Adasme

Associate Researcher

Centro de Investigación Clínica Avanzada (CICA)

Universidad Chile

Santiago, Chile

1
Agustin Martinez

Profesor Titular

Instituto de Neurociencia

UNIVERSIDAD DE VALPARAÍSO, CENTRO INTERDISCIPLINARIO DE NEUROCIENCIAS DE VALPARAÍSO

Valparaíso, Chile

1
Nibaldo Inestrosa

Full Professor

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

1
Gonzalo Terreros

Assistant Professor

Instituto de Ciencias de la Salud

Universidad de O'Higgins

Rancagua, Chile

1
Horacio Poblete

Profesor Conferenciante

Universidad de Talca

Talca, Chile

1
Barbara Bruna

Asistente de Investigación

Hospital Clinico universidad de Chile-Universidad de Chile

Santiago, Chile

1
Pablo Moya

Full Professor

Physiology

Universidad de Valparaiso

Valparaiso, Chile

1
Alvaro Ardiles

Assistant Professor

Medicine

Universidad de Valparaíso

Valparaiso, Chile

1
Pablo Olivero

Profesor Adjunto

Patologia y Fisiologia

Universidad de Valparaiso

Viña del Mar, Chile

1
Ivanny Marchant

ESCUELA DE MEDICINA UNIVERSIDAD DE VALPARAISO

Valparaiso, Chile

1
gabriela zavala

Investigador post-doctoral

Cells for Cells

Universidad de los Andes

Santiago, Chile

1
Alexies Dagnino

Full Professor

Physiology

UNIVERSIDAD DE VALPARAÍSO

Valparaíso, Chile

1
José Galaz

Estudiante de Posgrado

Instituto de Investigación en Ciencias Odontológicas

Universidad de Chile

Santiago, Chile

1
Claudio Cordova

Investigador asistente

Medicina

Universidad de Valparaíso

Valparaíso, Chile

1
Andrea Paula-Lima

Assistant Professor

Institute for research in Dental Sciences

Universidad de Chile

Santiago, Chile

1
Maria Aylwin

Associate Professor

Universidad de Talca

Talca, Chile

1
Ricardo Ramírez

Coordinador académico

Universidad Andrés Bello

Viña del Mar, Chile

1
Karen Castillo

Investigadora

Laboratorio de Sensores Moleculares, Centro Interdisciplinario de Neurociencia de Valparaíso (CINV), Facultad de Ciencias, Universidad de Valparaíso

Valparaiso, Chile