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José Luis Valdés Guerrero

Profesor Asociado

UNIVERSIDAD DE CHILE

Santiago, Chile

APRENDIZAJE y MEMORIA; ALERTA Y MOTIVACION; SISTEMAS NEUROMODULADORES;

Ciencias Biomedicas, UNIVERSIDAD DE CHILE. Chile, 2005
Biologia, PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE. Chile, 1999

Profesor Asistente Full Time

UNIVERSIDAD DE CHILE

Medicina

Santiago, Chile

2009 - 2017
Profesor Asociado Full Time

UNIVERSIDAD DE CHILE

Medicina

Santiago, Chile

2017 - A la fecha

Postdoctorado Full Time

Pontificia UNiversidad Catolica de Chile

Santiago, Chile

2005 - 2006
Postdoctorado Full Time

University of Arizona

Tucosn, Estados Unidos

2007 - 2008
Profesor Asociado Full Time

Universidad de Chile

Santiago, Chile

2009 - A la fecha

Magister en Neurociencias (Universidad de Chile)
Mabel Barceló (2005); Felipe Faundez (2024); Francisca Verdugo (2024);Morin Henríquez (2024); Luis Antilao (2023); Camila Ramirez (2022); Hector Espinoza (2022); Nicole Abarca (2022); Norton Contreras (2021); Benjamin Carrasco (2020); Jessica Sanchez (2018); Rodrigo Cisneros (2017); Stephanie Cortez (2017); Javier Silva (2017); Marcos Domic (2017); Gonzalo Bustamante (2016); Mauricio Toro (2015); Jamileth More (2015); Noemí Grinspun (2013); Juan Pablo Osorio (2012).

Magister en Bioquimica (Universidad de Chile
Juan Galindo. Graduado (April del 2016).

Doctorado en Ciencias Biomédicas (Universidad de Chile)
Javier Rios (co-advisor, 2023); Miguel Concha (Co-advisor, 2019); Yerko Fuentealba (2018); Noemi Grinspun (2017); Ingrid Buller (2017).

Doctorado en Ciencias Medicas (Universidad de Chile)
NIcole Rogers Graduada (10 de enero, 2019)

Doctorado en Neurociencias (PUCCH)
Maria Alexandra Garcia (2022).

Postdoc
Marcos Contreras (2010-2012)
Margarita Borquez (2017-2018)
Alexandra Garcia (2022-2023)


Aging Favors Calcium Activation of Ryanodine Receptor Channels from Brain Cortices and Hippocampi and Hinders Learning and Memory in Male Rats More, Jamileth; Finkelstein, Jose Pablo; Valdes, Jose Luis; Hidalgo, Cecilia; Bull, Ricardo Article ISI INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2025)
Cortico-Hippocampal Oscillations Are Associated With the Developmental Onset of Hippocampal-Dependent Memory Garcia-Perez, Maria A.; Tiznado, Vicente Article ISI FRONTIERS IN NEUROSCIENCE (2022)
Females of the four-eyed frog,<i> Pleurodema</i><i> thaul</i> (Anura, Leptodactylidae), respond behaviourally to conspecific male scent Labra, Antonieta Article ISI HERPETOZOA (2021)
Alzheimer's Disease-Like Pathology Triggered by Porphyromonas gingivalis in Wild Type Rats Is Serotype Dependent Jimenez-Union, Matias; Villalobos-Orchard, Francisca; Munoz-Manriquez, Constanza; Monasterio, Gustavo; Vernal, Rolando Article ISI FRONTIERS IN IMMUNOLOGY (2020)
Differential navigational strategies during spatial learning in a new modified version of the Oasis maze Sanchez, Cristian Article ISI SCOPUS Behavioural Brain Research (2020)
Intranasal Administration of Mesenchymal Stem Cell Secretome Reduces Hippocampal Oxidative Stress, Neuroinflammation and Cell Death, Improving the Behavioral Outcome Following Perinatal Asphyxia Farfan, Nancy; Carril, Jaime; Redel, Martina; Zamorano, Marta; Araya, Maureen; Monzon, Estephania; Alvarado, Raul; Contreras, Norton; Israel, Yedy Article ISI INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)
c-Fos expression in the ascending arousal system induced by physical exercise in rats: Implication for memory performance Grinspun N.; Fuentealba Y. Article ISI SCOPUS BRAIN RESEARCH (2019)
Effort Displayed During Appetitive Phase of Feeding Behavior Requires Infralimbic Cortex Activity and Histamine H1 Receptor Signaling Riveros M.E.; ValdÃ©s J.L. Article ISI SCOPUS FRONTIERS IN NEUROSCIENCE (2019)
Timing Is of the Essence: Improvement in Perception During Active Sensing Concha-Miranda, Miguel; Rios, Javier; Bu, Joaquin; Maldonado, Pedro. E. Article ISI SCOPUS Frontiers in Behavioral Neuroscience (2019)
Calcium Release Mediated by Redox-Sensitive RyR2 Channels Has a Central Role in Hippocampal Structural Plasticity and Spatial Memory More, Jamileth Y.; Lobos, Pedro E.; Galaz, José L.; Figueroa, Paula L.; Namias, Silvia Article ISI SCOPUS ANTIOXIDANTS & REDOX SIGNALING (2018)
Long-lasting, reversible and non-neurotoxic inactivation of hippocampus activity induced by neosaxitoxin Torrealba, F.; Valdes, J. L. Article ISI SCOPUS JOURNAL OF NEUROSCIENCE METHODS (2018)
N-Acetylcysteine Prevents the Spatial Memory Deficits and the Redox-Dependent RyR2 Decrease Displayed by an Alzheimer's Disease Rat Model More, Jamileth; Galusso, Nadia; Montecinos, Luis; Pablo Finkelstein, Jose; Bull, Ricardo; Luis Valdes, Jose Article ISI FRONTIERS IN AGING NEUROSCIENCE (2018)
Triclosan Impairs Hippocampal Synaptic Plasticity and Spatial Memory in Male Rats Arias-Cavieres, Alejandra; Miguel Vicente, Jose; Adasme ,Tatiana; Hidalgo, Jorge; Humeres, Alexis; Valdes-Undurraga, Ismael; Barrientos, Genaro Article ISI SCOPUS Frontiers in Molecular Neuroscience (2018)
Asynchronous ripple oscillations between left and right hippocampi during slow-wave sleep Article ISI SCOPUS PloS one (2017)
Local Klotho enhances neuronal progenitor proliferation in the adult hippocampus Salech Felipe Couve A.; Andaur, Gabriela; Ponce, Daniela; Valdes, Jose L; Beherens, Maria I.; Couve, Andrés Article ISI J Gerontol A Biol Sci Med Sci. (2017)
Targeting Sentinel Proteins and Extrasynaptic Glutamate Receptors=> a Therapeutic Strategy for Preventing the Effects Elicited by Perinatal Asphyxia? Herrera-Marschitz, M; Perez-Lobos, R; Lespay-Rebolledo, C; Tapia-Bustos, A; Casanova-Ortiz, E; Morales, P; Valdes, JL; Bustamante, D; Cassels, BK Article NEUROTOXICITY RESEARCH (2017)
Effect of perinatal asphyxia on tuberomammillary nucleus neuronal density and object recognition memory=> A possible role for histamine? Flores-Balter, Gabriela; Cordova-Jadue, Hector; Chiti-Morales, Alessandra; Lespay Caroline, Espina-Marchant Pablo; Falcon Romina, Grinspun; Noemi, Sanchez Jessica; Bustamante, Diego; Morales, Paola; Herrera-Marschitz, Mario Article BEHAVIOURAL BRAIN RESEARCH (2016)
Regulation of Memory Formation by the Transcription Factor XBP1 Martínez, Gabriela; Vidal, Rene; Mardones, Pablo; Serrano, Felipe; Ardiles, Alvaro; Wirth, Craigh; Valdés, Pamela; Thielen, Peter; Schneider, Bernard; Kerr, Bredford; Valdés, Jose Luis; Palacios, Adrian; Inestrosa, Nibaldo; Glimcher, Laurie; Hetz, Claudio. Article Cell Reports (2016)
The Histaminergic Tuberomamillary Nucleus Is Involved in Appetite for Sex, Water and Amphetamine Contreras, Marco; Riveros, Maria; Quispe, Maricel; Sánchez, Cristian; Perdomo, Guayec; Torrealba, Fernando; Valdés, Jose Luis. Article PLoS One (2016)
Lack of phonotactic preferences of female frogs and its consequences for signal evolution. Velásquez, Nelson A; Valdés, Jose Luis; Vásquez, Rodrigo A; Penna, Mario Article Behavioural processes (2015)
Off-Line Reactivation of Experience-Dependent Neuronal Firing Patterns in the Rat Ventral Tegmental Area. Valdes, Jose L; McNaughton, Bruce L; Fellous, Jean-Marc Article Journal of neurophysiology (2015)
Further Studies on the Hypothesis of PARP-1 Inhibition as a Strategy for Lessening the Long-Term Effects Produced by Perinatal Asphyxia: Effects of Nicotinamide and Theophylline on PARP-1 Activity in Brain and Peripheral Tissue Allende-Castro C.; Espina-Marchant, P; Bustamante D.; Rojas-Mancilla, E; Neira, T; Esmar D.; Valdes, J. L.; Morales P.; Herrera-Marschitz, M Article ISI SCOPUS Neurotoxicity Research (2012)
Histamine and motivation. Torrealba, Fernando; Riveros, Maria E; Contreras, Marco; Valdes, Jose L Article Frontiers in systems neuroscience (2012)
The histaminergic tuberomammillary nucleus is critical for motivated arousal. Valdés, José Luis; Sánchez, Cristián; Riveros, María Eugenia; Blandina, Patrizio; Contreras, Marco; Farías, Paula; Torrealba, Fernando Article The European journal of neuroscience (2010)
The parietal association cortex of the rat. Torrealba, Fernando; Valdés, José Luis Article Biological research (2008)
The infralimbic cortical area commands the behavioral and vegetative arousal during appetitive behavior in the rat. Valdés, José Luis; Maldonado, Pedro; Recabarren, Mónica; Fuentes, Rómulo; Torrealba, Fernando Article The European journal of neuroscience (2006)
Arousal and differential Fos expression in histaminergic neurons of the ascending arousal system during a feeding-related motivated behaviour. Valdés, J L; Farías, P; Ocampo-Garcés, A; Cortés, N; Serón-Ferré, M; Torrealba, F Article The European journal of neuroscience (2005)
Differential effects of infralimbic cortical lesions on temperature and locomotor activity responses to feeding in rats. Recabarren, M P; Valdés, J L; Farías, P; Serón-Ferré, M; Torrealba, F Article Neuroscience (2005)
Specific activation of histaminergic neurons during daily feeding anticipatory behavior in rats. Meynard, Margarita M; Valdés, José Luis; Recabarren, Mónica; Serón-Ferré, María; Torrealba, Fernando Article Behavioural brain research (2005)


Molecular, cellular and behavioural effects produced by perinatal asphyxia: protection by poly(ADP-ribose) polymerase 1 (PARP-1) inhibition Neira, T; Esmar D.; Rivera B.; Valdes, JL; Hermoso, M BookSection (2014)


Mesenchymal stem cell-derived secretome: A multitarget intervention to reduce long-term disabilities induced by in utero opioid exposure Ezquer, Eduardo Fernando Proyecto (2024)
Apoyo a la formación de Redes Internacionales entre centros de Investigación Proyecto (2019)
Mesenchymal stem cells-secretome provides protection in neonatal hypoxia-reoxygenation. Mechanisms and translational studies Proyecto (2019)
Test de navegación virtual detecta de forma rápida y precisa el deterioro cognitivo inicial en personas mayores Proyecto (2019)
The precise timing of motor modulations as a mechanism for active sensing in the visual system Proyecto (2019)
Biomedical Neuroscience Institute couve, a Proyecto (2011)
Center for Neuroscience of Memory, (CENEM), Proyecto (2010)
High order perception of needs and emotions Torrealba, Fernando Proyecto (2010)
Role of hippocampal histaminergic activity during acquisition and consolidation of memory Valdes, Jose L Proyecto (2009)
Defective Calcium/Redox signaling and anomalous elctrical brain activity in rats injected with amyloid beta oligomers: Functional and behavioural correlates with alzheimer's patients Paula-Lima, A; Maldonado,P; Hidalgo, MC Proyecto (0)


Targeting Sentinel Proteins and Extrasynaptic Glutamate Receptors: a Therapeutic Strategy for Preventing the Effects Elicited by Perinatal Asphyxia? Review ISI NEUROTOXICITY RESEARCH (2018)