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Tatiana Marlene Adasme Rocha

Coordinadora de Estudios

Universidad Chile

Santiago, Chile

Synaptic plasticity and Memory; Calcium Signals; Redox signaling; Calcium and Redox regulated Transcriptional Factors; Signal transduction in Aging

Biochemist, UNIVERSIDAD DE CHILE. Chile, 2004
Biochemist bachelor, UNIVERSIDAD DE CHILE. Chile, 2004
Doctor in Biochemistry, UNIVERSIDAD DE CHILE. Chile, 2009

Teacher and coordinator Part Time

Universidad de Artes, Ciencias y Comunicación (UNIACC)

Santiago, Chile

2014 - 2015
Physiology teacher Part Time

Universidad San Sebastian

Santiago, Chile

2009 - 2010
Physiology teacher Part Time

Universidad Autónoma

Santiago, Chile

2010 - 2010
Physiology teacher Full Time

Universidad Bernardo O´Higgins

Facultad de Ingeniería, Ciencias y Tecnología

Santiago, Chile

2017 - 2019
Physiology teacher Full Time

Universidad de Bernardo O´Higgins

Health

Santiago, Chile

2016 - 2020
Physiology teacher Part Time

UNIVERSIDAD DE VALPARAISO

Facultad de Medicina

Santiago, Chile

2006 - 2006
teacher for Intracellular Calcium signals course Part Time

UNIVERSIDAD DE CHILE

Facultad de Medicina

Santiago , Chile

2007 - 2008
Teacher for Biomedicine I and II (this course is lectured each 2 years) Part Time

UNIVERSIDAD DE CHILE

Facultad de Medicina

Santiago, Chile

2014 - 2020
Teacher and evaluator of Research Units Other

UNIVERSIDAD DE CHILE

Facultad de Medicina

Santiago, Chile

2012 - 2017
teacher Part Time

UNIVERSIDAD DE CHILE

Medicine

Santiago, Chile

2018 - 2019
Physiology teacher Full Time

Universidad Bernardo O´Higgins

Health

Santiago, Chile

2016 - 2020
laboratory teacher Part Time

UNIVERSIDAD DE CHILE

Medicine

Santiago, Chile

2019 - 2019
teacher Full Time

UNIVERSIDAD BERNARDO O'HIGGINS

Sciences of health

Santiago, Chile

2019 - 2020
teacher Full Time

UNIVERSIDAD BERNARDO O'HIGGINS

Health

santiago, Chile

2020 - 2020
Cellular and genetical Biology teacher Part Time

UNIVERSIDAD BERNARDO O'HIGGINS

Health

Santiago, Chile

2020 - 2020
profesora adjunta Part Time

UNIVERSIDAD DE CHILE

Facultad de Odontología

Santiago, Chile

2024 - A la fecha

Researcher, FONDAP/CEMC Fellowship Full Time

Universidad de Chile/Facultad de medicina/ Laboratorio de Señales de Calcio

Santiago, Chile

2009 - 2011
postdegree CONICYT fellowship Full Time

Universidad de Chile/Facultad de medicina/ Laboratorio de Señales de Calcio

Santiago, Chile

2006 - 2009
Member of professional team, FONDECYT 1050768 Part Time

Universidad de Chile/Facultad de Ciencias Químicas y Farmacéuticas/ Laboratorio de Transducción de señales moleculares de la célula

Santiago, Chile

2005 - 2006
member of Professional team proyecto FONDECYT 1050690 Part Time

Universidad de los Andes/ Laboratorio de Bioquímica y Fisiología celular

Santiago, Chile

2004 - 2005
undergraduate in professional thesis Full Time

Universidad de Chile/Facultad de Ciencias Químicas y Farmaceúticas/ Laboratorio de Transducción de señales

Santiago, Chile

2002 - 2004
student in laboratory Part Time

Universidad de Chile/Facultad de Ciencias/ Laboratorio de Bioquímica

Santiago, Chile

1999 - 2000
Investigadora CIBQA Full Time

Universidad Bernardo O´Higgins

Santiago, Chile

2016 - 2020
BNI researcher in collaboration Part Time

Universidad de Chile/Facultad de medicina/ Laboratorio de Señales de Calcio

Santiago, Chile

2014 - A la fecha
Adjunct Professor, Faculty of Medicine Part Time

Universidad de Chile

Santiago, Chile

2019 - 2019
advisory committee Other

ANID/FONDEQUIP

Santiago, Chile

2019 - A la fecha
Evaluadora Panel Instrumentos Bionalíticos Part Time

ANID/FONDEQUIP

Santiago, Chile

2018 - 2018
Coordinadora Clinica/Investigadora Part Time

Clinica Psiquiatrica/HCUCH

Santiago, Chile

2022 - 2024
Investigadora Part Time

CICA, Centro de Investigación Clinica Avanzada

Santiago, Chile

2020 - A la fecha
COORDINADORA DE ESTUDIOS Full Time

Hospital Clinico Universidad de CHILE

Santiago, Chile

2024 - A la fecha

Training of Young Investigators
1. Undergraduated Thesis: Italo Espinoza Fuenzalida; “The field electrical stimulation modulates the RyR2 expression in primary hippocampal neurons”; 2007-2010; Universidad de Chile; CHILE; Thesis for to be Biochemist. Function: co-director; director: Dra. María Angélica Carrasco. Laboratorio de Bioquímica Celular, Facultad de Medicina, Universidad de Chile.

2. Undergraduated Thesis: Karla Cataldo, Patricio Farías; Daniela Meza; “Efecto de la Astaxantina sobre la translocación del Factor Nuclear kappa B en hipocampo de ratas envejecidas y en células PC12”; Universidad de Valparaíso; CHILE; Thesis for to be Medical Technologist. Function: co-advisor; advisor: Dr. Pablo Munoz. Laboratory of Cellular and Molecular Plasticity, Facultad de Medicina, Universidad de Valparaíso.

3. Magister Thesis: Bábara Bruna Jara; “Involvement of the transcription factor Nrf2 in the increases of RyR2 expression induced of BDNF.”; 2015-2017; Universidad de Chile; CHILE; Master in Biochemistry Thesis. Function: co-director; Director: Dra. Andrea Paula-Lima. Laboratory of Celular and Molecular Biology, Faculty of Dentistry, Universidad de Chile.
- Professional trainee: Italo Espinoza Fuenzalida; “Detection of peroxide in hippocampal primary neurons stimulated electrically” Function: Chief professor. Laboratory of Celular Biochemistry, Faculty of Medicine, Universidad de Chile.

4. Magister Thesis: Marilyn Fonseca; “ Effects of beta-amyloid oligomers on Nrf2 nuclear translocation and expression of antioxidant enzymes in primary hippocampal neurons”; 2018 – in course; Universidad Bernardo O´Higgins; CHILE; Master in Chemical and Biological Sciences. Function: Advisor; co-advisor: Dra. Andrea Paula-Lima. Laboratory of Cellular and Molecular Biology, Faculty of Dentistry, Universidad de Chile.

Early scientific training for undergraduate and post degree students.

1. 2012-2019: 19 Undergraduate students, Medicine School (second year), Faculty of Medicine, Universidad de Chile. Function: Tutor. Laboratory of Calcium Signals, Faculty of Medicine, Universidad de Chile.
2. 2017-2017: 1 Postdegree student, Pharmacology program of PhD, Faculty of Chemical and Pharmaceutical Sciences, Universidad de Chile.
2. 2008-2017: 8 Undergraduate students, Biochemistry School (second year), Faculty of Chemical and Pharmaceutical Sciences, Universidad de Chile.
3. 2012: 1 Undergraduate student, Pharmacy and Chemistry School (4Th), Faculty of Chemical and Pharmaceutical Sciences, Universidad de Chile.

Committee member in Post degree Programs

- 2019-2020 - Member of the Master thesis evaluation committee. "Inhibition of ryanodine receptors prevents presynaptic changes induced by LTD" Tatiana Guncay, Master in Medical Sciences, Cellular and Molecular Biology, Universidad de Valparaíso.
- 2019- present – Member of Doctorate thesis evaluation committee. “Pannexin-1 regulates dendrite branching and dendritic spines formation in hippocampal neurons by modulating actin polymerization through Rho GTPases.” Carolina Flores, PhD in Sciences, Neurosciences.

1. Project for development of critical and scientific thinking in students of middle education at Instituto Miguel León Prado. October-December 2015 and 2018.

2. Internship at the Institute of Neurobiology of Magdeburg, Germany, Leibniz Institute for Neurobiology (LIN), preparation of joint research project with Dr. Rodrigo Herrera Molina, Co-leader of the group in the Department of Neurochemistry and Molecular Biology of LIN . August 29 - September 13, 2017.

3. Project for the development of critical and scientific thinking for students of middle education at Instituto Miguel León Prado. October-December 2018.

4. Project for development of critical and scientific thinking for pre-basic and middle education students at Instituto Miguel León Prado. October-December 2015.
5. EXPLORA CONICYT; guide professor, Universidad de Chile, Open house Cicle 2008.

6. EXPLORA CONICYT: Cientific Committee evaluator, second stage of selected works evaluation, 8th School Meeting of Science and technology, EXPLORA CONICYT, Región Metropolitana, Universidad Católica de Chile, October 2013.

Doctoral thesis fellowship AT-24080073

COMISION NACIONAL DE INVESTIGACION CIENTIFICA Y TECNOLOGICA

Chile, 2008

Fellowship for the performing of doctoral thesis (complement to D-21060628) from CONICYT (Comisión Nacional de Investigación Científica y Tecnológica), AT-24080073, Gobierno de Chile, (2008).
Doctoral Fellowship, CONICYT D-21060628

COMISION NACIONAL DE INVESTIGACION CIENTIFICA Y TECNOLOGICA

Chile, 2006

CONICYT (Comisión Nacional de Investigación Científica y Tecnológica) Doctoral fellowship, D-21060628, Gobierno de Chile (2006-2009).
Fellowship for Scientific Meeting assistance

UNIVERSIDAD DE CHILE

Chile, 2007

Fellowship from Universidad de Chile for present and participate to the Course entitled “Neurochemical & Cellular Mechanism of Neuronal Damage. Therapeutical approaches”, Marzo 22-25, Pucón, Chile, 2007.
Brazilian Academy of Sciencies 13rd TWAS-ROLAC

The World Academy of Science

Chile, 2013

Awarded with fellowship to travel and preset my research (poster session) in “13rd TWAS-ROLAC Young Scientists Conference ”. Río de Janeiro, 6-8 de Mayo, 2013.
Chilean Neuroscience society fellowship

Chilean Society of Neuroscience

Chile, 2013

Awarded for travel and present my postdegree research in the session of Young Neuriscientist meeting, " IX Annual Meeting of Chilean Neurosciente Society and VIII Meeting of Latinoamerican Biophysics. Valparaíso, 1-4 de Octubre, 2013, Chile.
FONDEQUIP Technical committee member

COMISION NACIONAL DE INVESTIGACION CIENTIFICA Y TECNOLOGICA

Chile, 2019

Member of national committee of Fund of scientific and technologic equipment from January 2019.
Member of Group III: Bioanalitical Instruments Evaluator

FONDEQUIP

Chile, 2018

Member of evaluation pannel.


Long-term potentiation and spatial memory training stimulate the hippocampal expression of RyR2 calcium release channels Valdes-Undurraga, Ismael; Lobos, Pedro; Sanchez-Robledo, Virginia; Arias-Cavieres, Alejandra; SanMartin, Carol D.; Barrientos, Genaro; More, Jamileth; Munoz, Pablo; Cristina Paula-Lima, Andrea; Hidalgo, Cecilia; Adasme, Tatiana Article ISI FRONTIERS IN CELLULAR NEUROSCIENCE (2023)
RyR-mediated Ca2+ release elicited by neuronal activity induces nuclear Ca2+ signals, CREB phosphorylation, and Npas4/RyR2 expression Lobos, Pedro; Cordova, Alex; Vega-Vasquez, Ignacio; Ramirez, Omar A.; Adasme, Tatiana; Toledo, Jorge; Cerda, Mauricio; Hartel, Steffen; Paula-Lima, Andrea; Hidalgo, Cecilia Article ISI PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2021)
Astaxanthin Counteracts Excitotoxicity and Reduces the Ensuing Increases in Calcium Levels and Mitochondrial Reactive Oxygen Species Generation Garcia, Francisca; Lobos, Pedro; Ponce, Alejandra; Cataldo, Karla; Meza, Daniela; Farias, Patricio; Estay, Carolina; Oyarzun-Ampuero, Felipe; Herrera-Molina, Rodrigo; Paula-Lima, Andrea; Ardiles, Alvaro O.; Hidalgo, Cecilia; Adasme, Tatiana; Munoz, Pablo Article ISI Marine Drugs (2020)
Calcium Release Mediated by Redox-Sensitive RyR2 Channels Has a Central Role in Hippocampal Structural Plasticity and Spatial Memory More, Jamileth Y.; Bruna, Barbara A.; Lobos, Pedro E.; Galaz, José L.; Figueroa, Paula L.; Namias, Silvia; Sánchez, Gina L.; Barrientos, Genaro C.; Valdés, José L.; Paula-Lima, Andrea C.; Hidalgo, Cecilia; Adasme, Tatiana Article ISI SCOPUS ANTIOXIDANTS & REDOX SIGNALING (2018)
The signaling pathways underlying BDNF-induced Nrf2 hippocampal nuclear translocation involve ROS, RyR-Mediated Ca2+ signals, ERK and PI3K Bruna, Barbara; Lobos, Pedro; Herrera-Molina, Rodrigo; Hidalgo, Cecilia; Paula-Lima, Andrea; Adasme ,Tatiana Article ISI SCOPUS BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2018)
Triclosan Impairs Hippocampal Synaptic Plasticity and Spatial Memory in Male Rats Arias-Cavieres, Alejandra; More, Jamileth; Miguel Vicente, Jose; Adasme ,Tatiana; Hidalgo, Jorge; Luis Valdes, Jose; Humeres, Alexis; Valdes-Undurraga, Ismael; Sanchez, Gina; Hidalgo, Cecilia; Barrientos, Genaro Article ISI SCOPUS FRONTIERS IN MOLECULAR NEUROSCIENCE (2018)
Aging Impairs Hippocampal-Dependent Recognition Memory and LTP and Prevents the Associated RyR Up-regulation Arias-Cavieres A.; Adasme T.; Sánchez G.; Muñoz P.; Hidalgo C. Article ISI SCOPUS FRONTIERS IN AGING NEUROSCIENCE (2017)
Development of an iron-selective antioxidant probe with protective effects on neuronal function Garcia-Beltran, O; Mena, NP; Aguirre, P; Barriga-Gonzalez, G; Galdamez, A; Nagles, E; Adasme, T; Hidalgo, C; Nunez, MT Article ISI SCOPUS PLOS ONE (2017)
RyR2-Mediated Ca2+ Release and Mitochondrial ROS Generation Partake in the Synaptic Dysfunction Caused by Amyloid beta Peptide Oligomers SanMartín, Carol D.; Veloso, Pablo; Adasme, Tatiana; Lobos, Pedro; Bruna, Barbara; Galaz, Jose; García, Alejandra; Hartel, Steffen; Hidalgo, Cecilia; Paula-Lima, Andrea C. Article ISI SCOPUS FRONTIERS IN MOLECULAR NEUROSCIENCE (2017)
Astaxanthin Protects Primary Hippocampal Neurons against Noxious Effects of A beta-Oligomers Lobos, P; Bruna, B.; Cordova A.; Barattini, P; Galaz J.L.; Adasme, T.; Hidalgo C.; Muñoz P; Paula-Lima, A Article ISI SCOPUS NEURAL PLASTICITY (2016)
Inhibitory ryanodine prevents ryanodine receptor-mediated Ca2+ release without affecting endoplasmic reticulum Ca2+ content in primary hippocampal neurons Adasme, T.; Paula Lima A.; Hidalgo C. Article ISI SCOPUS BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2015)
The Antioxidant N-Acetylcysteine Prevents the Mitochondrial Fragmentation Induced by Soluble Amyloid-beta Peptide Oligomers SanMartin C.D.; Adasme, T.; Hidalgo C.; Paula Lima A.C. Article ISI SCOPUS Neurodegenerative Diseases (2012)
Amyloid beta-Peptide Oligomers Stimulate RyR-Mediated Ca2+ Release Inducing Mitochondrial Fragmentation in Hippocampal Neurons and Prevent RyR-Mediated Dendritic Spine Remodeling Produced by BDNF Paula-Lima, AC; Adasme, T.; SanMartin, C.; Sebollela A.; hetz C.; Carrasco MA; Ferreira, ST; Hidalgo C. Article ISI SCOPUS Antioxidants and Redox Signaling (2011)
High-Frequency Field Stimulation of Primary Neurons Enhances Ryanodine Receptor-Mediated Ca2+ Release and Generates Hydrogen Peroxide, Which Jointly Stimulate NF-kappa B Activity Riquelme, D.; Alvarez A.; Leal, N; Adasme, T.; Espinoza, I; Valdes, JA; Troncoso, N.; Hartel, S; Hidalgo J.; Hidalgo C.; Carrasco MA Article ISI SCOPUS Antioxidants and Redox Signaling (2011)
Involvement of ryanodine receptors in neurotrophin-induced hippocampal synaptic plasticity and spatial memory formation Adasme, T.; Haeger, P; Paula Lima A.C.; Espinoza, I; Casas-Alarcon M.M.; Carrasco M.A.; Hidalgo C. Article ISI SCOPUS Proceedings of the National Academy of Sciences of the United States of America (2011)
Increased Hippocampal Expression of the Divalent Metal Transporter 1 (DMT1) mRNA Variants 1B and +IRE and DMT1 Protein After NMDA-Receptor Stimulation or Spatial Memory Training Haeger, P; Alvarez A.; Leal, N; Adasme, T.; Nunez, MT; Hidalgo C. Article ISI SCOPUS Neurotoxicity Research (2010)
Increased Hippocampal Expression of the Divalent Metal Transporter 1 (DMT1) mRNA Variants 1B and +IRE and DMT1 Protein After NMDA-Receptor Stimulation or Spatial Memory Training Haeger P.; Alvarez, A; Leal N.; Adasme, T; Nunez, MT; Hidalgo, C Article NEUROTOXICITY RESEARCH (2010)
The transcription factor MEF2C mediates cardiomyocyte hypertrophy induced by IGF-1 signaling Munoz, JP; Collao, A; Chiong M.; Maldonado, C; Adasme, T.; CARRASCO L.; Ocaranza, P; Bravo, R.; Gonzalez L.; Diaz-Araya, G; Hidalgo C.; Lavandero S. Article ISI SCOPUS BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2009)
The transcription factor MEF2C mediates cardiomyocyte hypertrophy induced by IGF-1 signaling. Muñoz, Juan Pablo; Collao, Andres; Chiong, Mario; Maldonado, Carola; Adasme, Tatiana; Carrasco, Loreto; Ocaranza, Paula; Bravo, Roberto; Gonzalez, Leticia; Díaz-Araya, Guillermo; Hidalgo, Cecilia; Lavandero, Sergio Article Biochemical and biophysical research communications (2009)
IGF-1 protects cardiac myocytes from hyperosmotic stress-induced apoptosis via CREB Maldonado, C; Cea, P; Adasme, T.; Collao, A; Diaz-Araya, G; Chiong M.; Lavandero S. Article ISI SCOPUS BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2005)
IGF-1 protects cardiac myocytes from hyperosmotic stress-induced apoptosis via CREB. Maldonado, C; Cea, P; Adasme, T; Collao, A; Díaz-Araya, G; Chiong, M; Lavandero, S. Article Biochemical Biophysical Research Communication (2005)


Ryanodine receptor-mediated calcium release stimulates gene expression in neurons Hidalgo C.; Adasme, T.; Haeger, P; Carrasco MA Abstract ISI FEBS JOURNAL (2008)


BDNF through RyR-mediated Ca2+ release and ROS signaling induces Nrf2 translocation in hippocampal neurons. Bruna, B; Lóbos, P; Galaz, J; Hidalgo, C; Paula-Lima, A; Adasme, Tatiana ConferencePoster (2017)
BDNF-induced hippocampal structural plasticity requires ROS-stimulated RyR2-mediated Ca2+ release. Lóbos, P; Bruna, B; Galaz, J; Figueroa, P; Namias, S; Sanchez-Robledo, V; Arias, A; Barrientos, G; Paula-Lima, A; Hidalgo, C; Adasme, T. ConferencePoster (2017)
Ryanodine receptor mediated calcium signals and ROS jointly mediate BDNF-induced Nrf2 nuclear translocation in primary hippocampal neurons. Adasme, T; Bruna, B; Galaz, J; Lóbos, P; Paula-Lima, A; Hidalgo, C ConferencePoster (2016)
“Anomalous Calcium/Redox signaling in rats exposed to amyloid b-oligomers: Function and behavioral correlates with early Alzheimer patients.” Paula-Lima, A; More, J; Hafelin, R; Barattini, P; SanMartin, C; Adasme, T; Valdés, J; Behrens, M; Brunetti, E; Maldonado, P; Hidalgo, C ConferencePoster (2016)
“Ca2+ and ROS participate in BDNF signaling: a novel role for Nrf2” Bruna, B; Lóbos, P; Galaz, J; Hidalgo, C; Paula-Lima, A; Adasme, T ConferencePoster (2016)
“Calcium signals evoked in dendrites of primary rat hippocampal neurons engage RyR2- mediated calcium reléase for propagation to the nucleus.” Cordova, J; Ramirez, O; Lóbos, P; Bruna, B; Galaz, J; Adasme, T; Cerda, M; Paula-Lima, A; Couve, A; Hartel, S; Hidalgo, C ConferencePoster (2016)
“RyR2-mediated Calcium release has a key role in hippocampal synaptic plasticity and memory processes and its defective in a rat model of Alzheimer disease.” Hidalgo, C; Adasme, T; More, J; Valdés, I; Arias-Cavieres, A; SanMartin, C; Casas, M; Barrientos, G; Valdés, J; Sánchez, G; Muñoz, P; Haeger, P; Paula-Lima, A ConferencePoster (2016)
BDNF increase RyR2 expression through Ca2+ and ROS signaling induced Nrf2 translocation in hippocampal neurons. Bruna, B; Galaz, J; Lóbos, P; Hidalgo, C; Paula-Lima, A; Adasme, T ConferencePoster (2015)
Neuronal structural plasticity and LTP induction require Ryanodine Receptor mediated Ca2+ release. Adasme, T; Bruna, B; Valdés, I; SanMartin, C; More, J; Namias, S; Riquelme, A; Barrientos, G; Muñoz, P; Sánchez, G; Paula-Lima, A; Hidalgo, C ConferencePoster (2015)


Trajectories and Predictors in the Clinical High Risk for Psychosis Population: Prediction Scientific Global Consortium (PRESCIENT) Gaspar, Pablo; Adasme, Tatiana; Castillo, Rolando; Mayol, Rocío; Corral, Sebastián; Zamorano, Francisco; Bruna, Alejandro; Contreras, Pamela Proyecto The laboratory of translational psychiatry leader and the Santiago team participate in this multicenter and longitudinal project, which is led by Barnaby Nelson, Ph.D., head of ultra-high risk for psychosis research at the Center for Youth Mental Health, Australia. (2020)
Una inmunoterapia efectiva para el tratamiento de la enfermedad de Alzheimer: ensayo pre-clínico Behrens, María Isabel; Lopez, Mercedes N.; Adasme ,Tatiana; Salazar, Flavio A.; GLEISNER, MA; Duran-Aniotz C.A.; Ponce, D; Salech, Felipe Proyecto (2020)
“Herramienta multimodal no invasiva para el diagnóstico diferencial entre depresión y enfermedad de ALZHEIMER inicial” Paula Lima, Andrea Cristina; Adasme ,Tatiana Proyecto (2020)
Unveiling how neuronal calcium signals reach the nucleus following synapse activation PCI (BMBF180051) Proyecto 2019-2022 Coinvestigador(a)
“Unveiling how neuronal calcium signals reach the nucleus following synapse activation” Hidalgo, Cecilia; Paula Lima, Andrea Cristina; Adasme ,Tatiana; Barrientos G.C.; Hidalgo J.; Sanches,G Proyecto (2019)
Hippocampal Ryanodine ReceptorsCalcium Release Channels Mediate Activity-Generated Postsynaptic Calcium Signals and their Propagation to the Nucleus FONDECYT (1170053) Proyecto 2017-2020 Coinvestigador(a)
“Hippocampal Ryanodine Receptors Calcium Release Channels Mediate Activity Generated Postsynaptic Calcium Signals and their Propagation to the Nucleus” Hidalgo, Cecilia; Adasme, Tatiana; Barrientos, Genaro; Hidalgo, Jorge Proyecto (2017)
“Calcium- and ROS-signaling, key cellular pathways underlying BDNF induced plasticity” FONDECYT (11140580) Proyecto 2014-2017 Inv. Responsable
“Calcium- and ROS-signaling, key cellular pathways underlying BDNF induces plasticity” Adasme, Tatiana Proyecto (2014)
“Participación de la liberación de calcio mediada por RyR en respuesta a BDNF en la activación de cascadas de señales que inducen la expresión de proteínas esenciales para la plasticidad sináptica y memoria espacial”. Adasme, Tatiana Proyecto (2012)
PARTICIPACION DE LA LIBERACION DE CALCIO MEDIADA POR RYR EN RESPUESTA A BDNF EN LA ACTIVACION DE CASCADAS DE SEÑALES QUE INDUCEN LA EXPRESION DE PROTEINAS ESENCIALES PARA LA PLASTICIDAD SINAPTICA Y MEMORIA ESPACIAL. FONDECYT (3120093) Proyecto 2011-2014 Inv. Responsable
Partial differential equations for 3D photon denoising, optical flow and adjacent active surface models for high throughput in vivo spinning disk microscopy Hartel, Stephen; Adasme, T. Proyecto (2009)
PARTIAL DIFFERENTIAL EQUATIONS FOR 3D PHOTON DENOISING, OPTICAL FLOW AND ADJACENT ACTIVE SURFACE MODELS FOR HIGH THROUGHPUT IN VIVO SPINNING DISK MICROSCOPY FONDECYT (1090246) Proyecto 2009-2012 Coinvestigador(a)
PARTIAL DIFFERENTIAL EQUATIONS FOR 3D PHOTON DENOISING, OPTICAL FLOW AND ADJACENT ACTIVE SURFACE MODELS FOR HIGH THROUGHPUT IN VIVO SPINNING DISK MICROSCOPY FONDECYT (1090246) Proyecto 2009-2012 Coinvestigador(a)
“Modulacion redox de reguladores transcripcionales en neuronas de hipocampo”. Carrasco, María Angélica; Adasme ,Tatiana Proyecto (2006)
MECANISMOS DE TRANSDUCCION DE SENALES DEL IGF-1=>REGULACION DIFERENCIAL DE FACTORES TRANSCRIPCIONALES ASOCIADOS A LOS PROCESOS DE HIPERTROFIA Y APOPTOSIS DEL CARDIOMIOCITO FONDECYT (1010246) Proyecto 2001-2004 Tesista


Contribution of Ca2+ Release Channels to Hippocampal Synaptic Plasticity and Spatial Memory: Potential Redox Modulation Paula-Lima, A.C., Adasme, T., Hidalgo, C. Review ISI SCOPUS ANTIOXIDANTS & REDOX SIGNALING (2014)

Tatiana Adasme

Coordinadora de Estudios

Oficina de Apoyo a la Investigación Clínica

Universidad Chile

Santiago, Chile

M. Cecilia Hidalgo

Professor

ICBM

Universidad de Chile

Santiago, Chile

Andrea Paula-Lima

Assistant Professor

Institute for research in Dental Sciences

Universidad de Chile

Santiago, Chile

Pedro Lobos

Posdoctoral Research

Universidad de Chile

Santiago, Chile

Barbara Bruna

Postdoctoral Researcher

Hospital Clinico universidad de Chile-Universidad de Chile

Santiago, Chile

PAOLA HAEGER

Associated professor

Ciencias Biomedicas

Universidad Catolica del Norte

COQUIMBO, Chile

Gina Sanchez

Profesor Asociado

ICBM

UNIVERSIDAD DE CHILE, FAC MEDICINA , ICBM

Santiago, Chile

Genaro Barrientos

Profesor Asistente

Fisiologia y Biofisica, ICBM

UNIVERSIDAD DE CHILE

Santiago, Chile

José Galaz

Estudiante de Posgrado

Instituto de Investigación en Ciencias Odontológicas

Universidad de Chile

Santiago, Chile

Jamileth More

Investigador

Neurologia

Hospital Clinico Universidad de Chile

Santiago, Chile

SERGIO LAVANDERO

Director

Advanced Center for Chronic Diseases (ACCDiS)

UNIVERSIDAD DE CHILE, FAC CIENCIAS QUÍMICAS Y FARMACÉUTICAS

Santiago, Chile

Carol San Martín

Profesora Asistente

Neurología y Neurocirugía

Universidad de Chile

Santiago, Chile

Marco Nuñez

Professor

Biology

Fac. Ciencias, Universidad de Chile

Santiago, Chile

jose valdes

Profesor Asociado

Neurociencia

UNIVERSIDAD DE CHILE

Santiago, Chile

Andrea Paula-Lima

Profesora Asociada

Instituto de Investigación en Ciencias Odontológicas

UNIVERSIDAD DE CHILE

Santiago, Chile

Italo Espinoza

Lab Manager

Centro de Biología Integrativa

Universidad Mayor de Chile

Santiago, Chile

Rodrigo Herrera

Group Leader (staff member)

Combinatorial NeuroImaging Core Facility

Leibniz Institute for Neurobiology

Magdeburg, Alemania

Steffen Härtel

Full Professor

Instituto de Ciencias Biomédicas

University of Chile

Santiago, Chile

Mario Chiong

Profesor

Departamento de Bioquímica y Biología Molecular

Universidad de Chile

Santiago, Chile

Juan Valdés

Head lab

Ciencias Biologicas

UNIVERSIDAD ANDRÉS BELLO

Santiago, Chile

Leticia Gonzalez

Profesional Apoyo a la Investigacion

Pontificia Universidad Católica de Chile

Santiago, Chile

Pablo Muñoz

Profesor titular

Patología y Fisiología

UNIVERSIDAD DE VALPARAÍSO

Valparaiso, Chile

Roberto Bravo

Assistant Professor

Institute of Nutrition and Food Technology (INTA), Universidad de Chile

Santiago, Chile

Felipe Oyarzún

Profesor Asociado

Ciencias y Tecnología Farmacéuticas

UNIVERSIDAD DE CHILE

Santiago, Chile

Denise Riquelme

Adjunct Professor

Biology

Universidad de Santiago

Santiago, Chile

Jorge Toledo

Investigador

Departamento de Anatomia y Biologia del Desarrollo

Universidad de Chile; Biomedical Neuroscience Institute (BNI)

Santiago, Chile

Omar Ramírez

Postdoc

UNIVERSITAT HEIDELBERG

Heidelberg, Alemania

ALEXIS HUMERES

DIRECTOR

MORFOFUNCIÓN

Universidad Diego Portales

SANTIAGO, Chile

Ignacio Vega

Asistente Técnico

ICBM

Universidad de Chile

Santiago, Chile

Tatiana Marlene Adasme Rocha

Líneas de Investigación

Educación

Biochemist, UNIVERSIDAD DE CHILE. Chile, 2004

Biochemist bachelor, UNIVERSIDAD DE CHILE. Chile, 2004

Doctor in Biochemistry, UNIVERSIDAD DE CHILE. Chile, 2009

Experiencia Académica

Teacher and coordinator Part Time

Physiology teacher Part Time

Physiology teacher Part Time

Physiology teacher Full Time

Physiology teacher Full Time

Physiology teacher Part Time

teacher for Intracellular Calcium signals course Part Time

Teacher for Biomedicine I and II (this course is lectured each 2 years) Part Time

Teacher and evaluator of Research Units Other

teacher Part Time

Physiology teacher Full Time

laboratory teacher Part Time

teacher Full Time

teacher Full Time

Cellular and genetical Biology teacher Part Time

profesora adjunta Part Time

Experiencia Profesional

Researcher, FONDAP/CEMC Fellowship Full Time

postdegree CONICYT fellowship Full Time

Member of professional team, FONDECYT 1050768 Part Time

member of Professional team proyecto FONDECYT 1050690 Part Time

undergraduate in professional thesis Full Time

student in laboratory Part Time

Investigadora CIBQA Full Time

BNI researcher in collaboration Part Time

Adjunct Professor, Faculty of Medicine Part Time

advisory committee Other

Evaluadora Panel Instrumentos Bionalíticos Part Time

Coordinadora Clinica/Investigadora Part Time

Investigadora Part Time

COORDINADORA DE ESTUDIOS Full Time

Formación de Capital Humano

Difusión y Transferencia

Premios y Distinciones

Doctoral thesis fellowship AT-24080073

Doctoral Fellowship, CONICYT D-21060628

Fellowship for Scientific Meeting assistance

Brazilian Academy of Sciencies 13rd TWAS-ROLAC

Chilean Neuroscience society fellowship

FONDEQUIP Technical committee member

Member of Group III: Bioanalitical Instruments Evaluator

Article (21)

Abstract (1)

ConferencePoster (9)

Proyecto (16)

Unveiling how neuronal calcium signals reach the nucleus following synapse activation

Hippocampal Ryanodine ReceptorsCalcium Release Channels Mediate Activity-Generated Postsynaptic Calcium Signals and their Propagation to the Nucleus

“Calcium- and ROS-signaling, key cellular pathways underlying BDNF induced plasticity”

PARTICIPACION DE LA LIBERACION DE CALCIO MEDIADA POR RYR EN RESPUESTA A BDNF EN LA ACTIVACION DE CASCADAS DE SEÑALES QUE INDUCEN LA EXPRESION DE PROTEINAS ESENCIALES PARA LA PLASTICIDAD SINAPTICA Y MEMORIA ESPACIAL.

PARTIAL DIFFERENTIAL EQUATIONS FOR 3D PHOTON DENOISING, OPTICAL FLOW AND ADJACENT ACTIVE SURFACE MODELS FOR HIGH THROUGHPUT IN VIVO SPINNING DISK MICROSCOPY

PARTIAL DIFFERENTIAL EQUATIONS FOR 3D PHOTON DENOISING, OPTICAL FLOW AND ADJACENT ACTIVE SURFACE MODELS FOR HIGH THROUGHPUT IN VIVO SPINNING DISK MICROSCOPY

MECANISMOS DE TRANSDUCCION DE SENALES DEL IGF-1=>REGULACION DIFERENCIAL DE FACTORES TRANSCRIPCIONALES ASOCIADOS A LOS PROCESOS DE HIPERTROFIA Y APOPTOSIS DEL CARDIOMIOCITO

Review (1)