Man

Genaro Christian Barrientos Briones

Profesor Asistente

UNIVERSIDAD DE CHILE

Santiago, Chile

Líneas de Investigación


Role of calcium in excitable cells; Secretion mechanisms during development; PHYSIOLOGY AND ENDOCRINOLOGY; INTRACELLULAR SIGNAL TRANSDUCTION; RAPID EFFECTS OF STEROID HORMONES; Señales mediadas por calcio en musculo; Biologia celular de muscuo; Electrofisiologia de celulas musculares

Educación

  •  Bilogia Celular Molecular y Neurociencia, UNIVERSIDAD DE CHILE. Chile, 2007
  •  Bioquímico, UNIVERSIDAD DE CHILE. Chile, 2000

Experiencia Académica

  •   Profesor Asistente Full Time

    UNIVERSIDAD DE CHILE

    Medicina

    Santiago, Chile

    2012 - A la fecha

Experiencia Profesional

  •   Postdoctoral Scholar Full Time

    University of California, Davis

    Davis, California, Estados Unidos

    2007 - 2010

  •   Postdoctoral Scholar Full Time

    University of California, Los Angeles

    Los ANgles, California, Estados Unidos

    2010 - 2011

Formación de Capital Humano


Codirector de la Tesis de Magister Magíster en Ciencias Médicas, mención en Biología Celular y Molecular de Tatiana Guncay. Titulo de la tesis: Inhibición de los receptores de ryanodina previene los cambios presinápticos en la depresión a largo plazo. 2020. Universidad de Valparaiso, Facultad de Medicina.

Codirector de la Tesis de MAGÍSTER EN FISIOPATOLOGÍA de Javiera Andrea Aguilera Miranda. Titulo de la tesis: Caracterización del inflamasoma NLRP3 en el músculo esquelético de ratones obesos insulinoresistentes. Facultad de Medicina, Universidad de Chile.



 

Article (31)

Long-term potentiation and spatial memory training stimulate the hippocampal expression of RyR2 calcium release channels
Activation of the NLRP3 Inflammasome Increases the IL-1β Level and Decreases GLUT4 Translocation in Skeletal Muscle during Insulin Resistance
Classic and Novel Sex Hormone Binding Globulin Effects on the Cardiovascular System in Men
NLRP3 Inflammasome: Potential Role in Obesity Related Low-Grade Inflammation and Insulin Resistance in Skeletal Muscle
Testosterone activates glucose metabolism through AMPK and androgen signaling in cardiomyocyte hypertrophy
Androgen-Regulated Cardiac Metabolism in Aging Men
The polyphenol ellagic acid exerts anti-inflammatory actions via disruption of store-operated calcium entry (SOCE) pathway activators and coupling mediators
Calcium Release Mediated by Redox-Sensitive RyR2 Channels Has a Central Role in Hippocampal Structural Plasticity and Spatial Memory
High-Fat-Diet-Induced Obesity Produces Spontaneous Ventricular Arrhythmias and Increases the Activity of Ryanodine Receptors in Mice
Mechanical stretch increases L-type calcium channel stability in cardiomyocytes through a polycystin-1/AKT-dependent mechanism
Role of ABCA1 on membrane cholesterol content, insulin-dependent Akt phosphorylation and glucose uptake in adult skeletal muscle fibers from mice
Ryanodine receptor-mediated calcium release has a key role in hippocampal LTD induction
Triclosan Impairs Hippocampal Synaptic Plasticity and Spatial Memory in Male Rats
Ca2+/Calmodulin-Dependent Protein Kinase II and Androgen Signaling Pathways Modulate MEF2 Activity in Testosterone-Induced Cardiac Myocyte Hypertrophy
Membrane Cholesterol in Skeletal Muscle=> A Novel Player in Excitation-Contraction Coupling and Insulin Resistance.
GSK-3β/NFAT Signaling Is Involved in Testosterone-Induced Cardiac Myocyte Hypertrophy.
GSK-3β/NFAT Signaling Is Involved in Testosterone-Induced Cardiac Myocyte Hypertrophy.
Cholesterol removal from adult skeletal muscle impairs excitation-contraction coupling and aging reduces caveolin-3 and alters the expression of other triadic proteins
Glucose-Dependent Insulin Secretion in Pancreatic beta-Cell Islets from Male Rats Requires Ca2+ Release via ROS-Stimulated Ryanodine Receptors
Gene dose influences cellular and calcium channel dysregulation in heterozygous and homozygous T4826I-RYR1 malignant hyperthermia-susceptible muscle.
Gene dose influences cellular and calcium channel dysregulation in heterozygous and homozygous T4826I-RYR1 malignant hyperthermia-susceptible muscle.
Triclosan impairs excitation-contraction coupling and Ca2+ dynamics in striated muscle.
Triclosan impairs excitation-contraction coupling and Ca2+ dynamics in striated muscle.
Basal Bioenergetic Abnormalities in Skeletal Muscle from Ryanodine Receptor Malignant Hyperthermia-susceptible R163C Knock-in Mice
Functional and Biochemical Properties of Ryanodine Receptor Type 1 Channels from Heterozygous R163C Malignant Hyperthermia-Susceptible Mice
Functional and biochemical properties of ryanodine receptor type 1 channels from heterozygous R163C malignant hyperthermia-susceptible mice.
The Na+/Ca2+ exchange inhibitor 2-(2-(4-(4-nitrobenzyloxy)phenyl)ethyl)isothiourea methanesulfonate (KB-R7943) also blocks ryanodine receptors type 1 (RyR1) and type 2 (RyR2) channels.
A transverse tubule NADPH oxidase activity stimulates calcium release from isolated triads via ryanodine receptor type 1 S-glutathionylation
Fast kinetics of calcium dissociation from calsequestrin
TNP-8N(3)-ADP photoinactivation of the phosphatase activity of FITC-modified SERCA
Annexin VI is attached to transverse-tubule membranes in isolated skeletal muscle triads

Abstract (3)

Role of RyR2-mediated calcium release in synaptic plasticity, learning and memory in control and AD-model rats
TNP-8N(3)-ADP photoinactivation and labelling of sarcoplasmic reticulum of skeletal muscle
Do adult skeletal muscle traverse tubules contain caveola?

Proyecto (9)

The NLRP3 Inflammasome in skeletal muscle: a novel link between cholesterol accumulation and the defective insulin-mediated glucose transport in insulin resistance
Hippocampal Ryanodine Receptors-Calcium Release Channels Mediate Activity-Generated Postsynaptic Calcium Signals and their Propagation to the Nucleus
Hippocampal Ryanodine Receptors-Calcium Release Channels Mediate Activity-Generated Postsynaptic Calcium Signals and their Propagation to the Nucleus
Red internacional para el estudio del transporte de glucosa y la exitabilidad celular del músculo esquelético en obesidad
ROLE OF RYANODINE RECEPTORS IN THE DEVELOPMENT OF CARDIAC HYPERTROPHY INDUCED BY A HIGH FAT DIET IN MICE
Role of Ryanodine receptors in the development of cardiac hypertrophy induced by a high fat diet in mice
Role of ryanodine receptors in the development on cardiac hypertrophy induced by a high fat diet in mice
PARTICIPATION OF CALCIUM- AND REDOX-INDUCED RYANODINE RECEPTOR-MEDIATED CALCIUM RELEASE IN SUSTAINED HIPPOCAMPAL LTP
ACTIVACION Y REGULACION DE LOS CANALES DE LIBERACION DE CALCIO-RECEPTORES DE RYANODINA DE MUSCULO Y NEURONAS
28
Genaro Barrientos

Profesor Asistente

Fisiologia y Biofisica, ICBM

UNIVERSIDAD DE CHILE

Santiago, Chile

9
Gina Sanchez

Profesor Asociado

ICBM

UNIVERSIDAD DE CHILE, FAC MEDICINA , ICBM

Santiago, Chile

8
M. Cecilia Hidalgo

Professor

ICBM

Universidad de Chile

Santiago, Chile

7
Paola Llanos

Profesor Asistente

Instituto de Investigacion en Ciencias Biomédicas

FACULTAD DE ODONTOLOGIA. UNIVERSIDAD DE CHILE

Santiago, Chile

3
Tatiana Adasme

Coordinadora de Estudios

Oficina de Apoyo a la Investigación Clínica

Universidad Chile

Santiago, Chile

3
Carla Basualto

Académico, Profesor Asociado

Departamento de Ciencias de la Salud

Universidad de Aysén

Coyhaique, Chile

3
Jamileth More

Investigador

Neurologia

Hospital Clinico Universidad de Chile

Santiago, Chile

3
Manuel Estrada

/Associate Professor / PI

Physiology and Biophysics

UNIVERSIDAD DE CHILE, FACULTAD DE MEDICINA, INSTITUTO DE CIENCIAS BIOMÉDICAS (ICBM), PROGRAMA DE FISIOLOGÍA Y BIOFÍSICA

Santiago, Chile

2
jose valdes

Profesor Asociado

Neurociencia

UNIVERSIDAD DE CHILE

Santiago, Chile

2
Paulina Donoso

Full Professor

Physiology and Biophysics

UNIVERSIDAD DE CHILE

Santiago, Chile

2
Jaime Riquelme

Assistant Professor

Química Farmacológica y Toxicológica

Universidad de Chile

Santiago, Chile

2
Zully Pedrozo

Associated Professor

Physiology and Biophysical

Universidad de Chile

SANTIAGO DE CHILE, Chile

2
Andrea Paula-Lima

Assistant Professor

Institute for research in Dental Sciences

Universidad de Chile

Santiago, Chile

2
Andrea Paula-Lima

Profesora Asociada

Instituto de Investigación en Ciencias Odontológicas

UNIVERSIDAD DE CHILE

Santiago, Chile

1
Barbara Bruna

Postdoctoral Researcher

Hospital Clinico universidad de Chile-Universidad de Chile

Santiago, Chile

1
José Galaz

Estudiante de Posgrado

Instituto de Investigación en Ciencias Odontológicas

Universidad de Chile

Santiago, Chile

1
Andrew Quest

Full Professor

Biologia Celular y Molecular

FACULTAD DE MEDICINA, UNIVERSIDAD DE CHILE

Santiago, Chile

1
ALEXIS HUMERES

DIRECTOR

MORFOFUNCIÓN

Universidad Diego Portales

SANTIAGO, Chile

1
Pedro Lobos

Posdoctoral Research

Universidad de Chile

Santiago, Chile

1
Patricio Silva

Investigador Principal FONDEF

Departamento de Biología Celular y Molecular

Universidad de Chile

Santiago, Chile