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Paulina Donoso Laurent

Full Professor

UNIVERSIDAD DE CHILE

Santiago, Chile

Líneas de Investigación


Cardiovascular physiology, cell calcium regulation, cardiac regulatory mechanism of hypertrophy, redox regulation

Educación

  •  Physiology, FACULTAD DE MEDICINA. Chile, 1988
  •  Biochemist, UNIVERSIDAD DE CHILE. Chile, 1974

Experiencia Académica

  •   Full Professor Full Time

    UNIVERSIDAD DE CHILE

    Medicine

    Santiago, Chile

    1974 - A la fecha

Experiencia Profesional

  •   Full professor Full Time

    Facultad de Medicina. Universidad de Chile

    Santiago, Chile

    1974 - A la fecha

Formación de Capital Humano


2018 Isidora Mujica. Master thesis supervisor: "Efecto de la obesidad producida por una dieta alta en grasa sobre el balance redox celular"

2017 Felipe Araneda Rios. Master thesis supervisor: "Arritmogénesis en ratones alimentados con dieta rica en ácidos grasos saturados"

2016 Pablo Romero Romano. Master thesis supervisor: "Rol de la policistina I en el daño inducido por Isquemia y reperfusión en el corazón"

2016 Yildy Priscilla Utreras Mendoza. PhD thesis supervisor: " Identificación de la vía de señalización asociada al desarrollo de hipertrofia cardiaca en ratones C57BL/6J alimentados con dieta alta en grasa "

2014 Javier Pezoa Muñoz. Master thesis supervisor: "Degradación de RyR2 en corazones de rata sometidos a isquemia-reperfusión: rol de las calpaínas y el proteasoma"



 

Article (8)

Inhibition of chymotrypsin-like activity of the proteasome by ixazomib prevents mitochondrial dysfunction during myocardial ischemia

Sanchez, Gina; Chalmers, Stefanie; Ahumada, Xavier; Montecinos, Luis; Olmedo, Ivonne; Eisner, Veronica; Riveros, Ana; Kogan, Marcelo J.; Lavandero, Sergio; Pedrozo, Zully; Donoso, Paulina

Article ISI
PLOS ONE  (2020)

Inhibition of the proteasome preserves Mitofusin-2 and mitochondrial integrity, protecting cardiomyocytes during ischemia-reperfusion injury

Olmedo I.; Pino G.; Riquelme, J. A.; Aranguiz P.; Díaz M.C.; López-Crisosto C.; Lavandero S.; Donoso P.; Pedrozo Z.; Sánchez G.

Article ISI SCOPUS
Biochimica et Biophysica Acta - Molecular Basis of Disease  (2020)

High-Fat-Diet-Induced Obesity Produces Spontaneous Ventricular Arrhythmias and Increases the Activity of Ryanodine Receptors in Mice

Sanchez, G; Araneda, F; Pena, JP; Finkelstein, JP; Riquelme, JA; Montecinos, L; Barrientos, G; Llanos, P; Pedrozo, Z; Said, M; Bull, R; Donoso, P

Article ISI SCOPUS
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES  (2018)

Mechanical stretch increases L-type calcium channel stability in cardiomyocytes through a polycystin-1/AKT-dependent mechanism

Cordova-Casanova, A; Olmedo, I; Riquelme, JA; Barrientos, G; Sanchez, G; Gillette, TG; Lavandero, S; Chiong, M; Donoso, P; pedrozo, Z

Article ISI SCOPUS
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH  (2018)

Activation of Chymotrypsin-Like Activity of the Proteasome during Ischemia Induces Myocardial Dysfunction and Death

Sanchez, Gina; Berrios, Daniela; Olmedo, Ivonne; Pezoa, Javier=> Riquelme; Jaime, Montecinos; L, Pedrozo; Zully, Donoso

Article
PLoS One  (2016)

Reversible redox modifications of ryanodine receptor ameliorate ventricular arrhythmias in the ischemic-reperfused heart

Becerra, R; Roman, B; Di Carlo, MN; Mariangelo, JI; Salas, M; Sánchez, G; donoso, P; Schinella, GR; Vittone, L; Wehrens, XH; Mundina-Weilenmann, C; Said, M

Article ISI SCOPUS
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY  (2016)

Exercise Preconditioning of Myocardial Infarct Size in Dogs Is Triggered by Calcium

Parra, VM; Macho P; Sánchez G; Donoso P.; Domenech RJ

Article ISI SCOPUS
Journal of Cardiovascular Pharmacology  (2015)

Stimulation of NOX2 in isolated hearts reversibly sensitizes RYR2 channels to activation by cytoplasmic calcium

Donoso, Paulina; Finkelstein, Jose Pablo; Montecinos, Luis; Said, Matilde; Sánchez, Gina; Vittone, Leticia; Bull, Ricardo

Article
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY  (2014)

BookWhole (1)

Posttranslational modifications of cardiac ryanodine receptors/calcium release channels by reactive oxygen species and reactive nitrogen species

Donoso P.; Hidalgo C.; Sánchez G

BookWhole SCOPUS
Systems Biology of Free Radicals and Antioxidants  (2014)

Proyecto (4)

The role of Polycystin-1 in the development of heart failure. T-tubule system regulation and c-MyC dependent BIN-1 expression

Pedrozo, Zully; Donoso, Paulina; Sanchez, Gina

Proyecto
 (2018)

. Role of ryanodine receptors in the development of cardiac hypertrophy induced by a high fat diet in mice

Donoso, Paulina; Sanchez, Gina; Bull, Ricardo; Pedrozo, Zully; Barrientos, Genaro

Proyecto
 (2016)

Effect of proteasome inhibition on the content of mitofusins 1 and 2 and the preservation of mitochondrial function following cardiac ischemia-reperfusion

Sanchez, Gina; Donoso, Paulina

Proyecto
 (2013)

Dynamic changes of cardiac ryanodine receptors during ischemia reperfusion and its relevance to the design of cardioprotective measures

Donoso, Paulina; Sánchez Vergara, Gina

Proyecto
 (2011)

11
Paulina Donoso

Full Professor

Physiology and Biophysics

UNIVERSIDAD DE CHILE

Santiago, Chile

7
Gina Sanchez

Profesor Asociado

ICBM

UNIVERSIDAD DE CHILE, FAC MEDICINA , ICBM

Santiago, Chile

4
Zully Pedrozo

Associated Professor

Physiology and Biophysical

Universidad de Chile

SANTIAGO DE CHILE, Chile

3
Jaime Riquelme

Assistant Professor

Química Farmacológica y Toxicológica

Universidad de Chile

Santiago, Chile

2
SERGIO LAVANDERO

Director

Advanced Center for Chronic Diseases (ACCDiS)

UNIVERSIDAD DE CHILE, FAC CIENCIAS QUÍMICAS Y FARMACÉUTICAS

Santiago, Chile

2
Ivonne Olmedo

Assistant Profesor

Programa de Fisiopatología

Universidad de Chile

Santiago, Chile

2
Genaro Barrientos

Profesor Asistente

Fisiologia y Biofisica, ICBM

UNIVERSIDAD DE CHILE

Santiago, Chile

1
Veronica Eisner

Associate Professor

Cellular and Molecular Biology

Pontificia Universidad Católica de Chile

Santiago, Chile

1
Paola Llanos

Profesor Asistente

Instituto de Investigacion en Ciencias Biomédicas

FACULTAD DE ODONTOLOGIA. UNIVERSIDAD DE CHILE

Santiago, Chile

1
Marcelo Kogan

Academico

Quimica Farmacologica y Toxicologica

UNIVERSIDAD DE CHILE, FACULTAD DE CIENCIAS QUÍMICAS Y FARMACÉUTICAS

Santiago, Chile

1
M. Cecilia Hidalgo

Professor

ICBM

Universidad de Chile

Santiago, Chile

1
Victor Parra

Médico titular

ICBM, Facultad de Medicina

Instituto Nacional del Tórax y Universidad de Chile

Santiago, Chile

1
Magda Díaz