Man

Ivonne Odette Olmedo Alegria

Assistant Profesor

Universidad de Chile

Santiago, Chile

Líneas de Investigación


My laboratory focuses in cardiac pathophysiology; we are studing the mitochondrial function and dynamic in cardiac hypertrophy induced by fructose (in vivo and in vitro models)

Educación

  •  Pharmacist, UNIVERSIDAD DE CHILE. Chile, 2007
  •  Pharmaceutical Sciences , UNIVERSIDAD DE CHILE. Chile, 2013

Experiencia Académica

  •   Assistant Professor Full Time

    UNIVERSIDAD DE CHILE

    Medicina

    Santiago, Chile

    2018 - A la fecha

Experiencia Profesional

  •   Assistant Professor Full Time

    Universidad de Chile

    Santiago, Chile

    2018 - A la fecha

Formación de Capital Humano


Human capital training

Undergraduate Thesis Students (Last 5 years):

-BS, Universidad San Sebastián. Paz Díaz. “Role of polycystin-1 in the expression of calcium handling proteins and excitation/contraction of the cardiomyocytes”. 2016.
-BS, Universidad San Sebastián. Cecilia Anríquez. “Effect of the proteasome inhibition in the mitochondrial dynamic of the cardiomyocytes during ischemia/reperfusion". 2015 .

MSc Thesis students (Last 5 years)

MS-Universidad de Chile. Carolina Conejeros, "Participation of Miro1 in hypertrophy in neonatal rat cardiomyocytes ". 2017
MS- Universidad de Chile. Xavier Ahumada. “Effect of the inhibition of the chymotrypsin like activity of the proteosome during ischemia, in the mitochondrial structure of the rat isolated heart”. 2016
MS-Universidad de Chile. Stefanie Grace Chalmers. “Cardioprotective effect of N-acetylcysteine ??in the damage produced by ischemia, on the content of Mitofusin 2, in the isolated heart of rat". 2016


Difusión y Transferencia


Young Investigator Symposium "Participation of Miro1 in death induced by ischemia / reperfusion and in the induction of hypertrophy in cardiomyocytes", in the XXXIII Reunión Anual de la Sociedad Chilena de Ciencias Fisiológicas together with the International Society for Heart Research, Latin American Section: Huilo Huilo, 2018.

EXPLORA, Participation in the National Week of Science and Technology, 2018.

COMMUNICATIONS: Since 2014, seven posters at national and international meetings.



 

Article (19)

Inhibition of Chymotrypsin-Like Activity of the Proteasome by Ixazomib Prevents Mitochondrial Dysfunction During Myocardial Ischemia
Inhibition of the proteasome preserves Mitofusin-2 and mitochondrial integrity, protecting cardiomyocytes during ischemia-reperfusion injury.
Miro1 as a novel regulator of hypertrophy in neonatal rat cardiomyocytes
TGF-β1 Induced Up-Regulation of B1 Kinin Receptor Promotes Antifibrotic Activity in Rat Cardiac Myofibroblasts
Mechanical Stretch Increases L-type Calcium Channel Stability in Cardiomyocytes Through a polycystin-1/AKT-dependent Mechanism
Activation of Chymotrypsin-Like Activity of the Proteasome During Ischemia Induces Myocardial Dysfunction and Death
4-Phenylbutyric Acid Prevent Cytotoxicity Induced by Thapsigargin in Rat Cardiac Fibroblast
4-Phenylbutyric acid prevent cytotoxicity induced by thapsigargin in rat cardiac fibroblast
TGF-β1 Prevents Simulated ischemia/reperfusion-induced Cardiac Fibroblast Apoptosis by Activation of Both Canonical and Non-Canonical Signaling Pathways
EPAC Expression and Function in Cardiac Fibroblasts and Myofibroblasts
Cardiac fibroblast death by ischemia/reperfusion is partially inhibited by IGF-1 through both PI3K/Akt and MEK-ERK pathways
Differential regulation of collagen secretion by kinin receptors in cardiac fibroblast and myofibroblast
Simvastatin disrupts cytoskeleton and decreases cardiac fibroblast adhesion, migration and viability
Simvastatin induces apoptosis by a Rho-dependent mechanism in cultured cardiac fibroblasts and myofibroblasts
Bioaccumulation and toxicity of gold nanoparticles after repeated administration in mice
Multifunctionalized Gold Nanoparticles with Peptides Targeted to Gastrin-Releasing Peptide Receptor of a Tumor Cell Line
Gold Nanoparticles and Microwave Irradiation Inhibit Beta-Amyloid Amyloidogenesis
How changes in the sequence of the peptide CLPFFD-NH(2) can modify the conjugation and stability of gold nanoparticles and their affinity for beta-amyloid fibrils
Ni/Ni Oxides Nanoparticles with Potential Biomedical Applications Obtained by Displacement of a Nickel-Organometallic Complex

Abstract (2)

Kinin B1 and B2 receptor activation reduces collagen I secretion through PKC-PLA2-COX2 participation in rat neonate cardiac myofibroblast
TGF-beta 1 regulates EPAC-1 protein expression and function in cardiac fibroblasts and myofibroblasts

BookWhole (1)

Nanoparticles Functionalized with Bioactive Molecules: Biomedical Applications

Proyecto (6)

Red para el estudio de enfermedades cardiopulmonares de alta letalidad (REECPAL)
Miro1 regulates mitochondrial function and dynamics in cardiac hypertrophy induced by fructose
Miro1 regulates mitochondrial function and dynamics in cardiac hypertrophy induced by fructose
"Effects of proteasome inhibition on the content of Mitofusins 1 and 2 and the preservation of mitochondrial function following cardiac ischemia reperfusion"
"Participation of Miro proteins in mitochondrial function during cardiac ischemia reperfusion "
PARTICIPACION DE LAS PROTEINAS MIRO EN LA FUNCION MITOCONDRIAL DURANTE ISQUEMIA/REPERFUSION CARDIACA.

Review (1)

Peptides and metallic nanoparticles for biomedical applications
25
Ivonne Olmedo

Assistant Profesor

Programa de Fisiopatología

Universidad de Chile

Santiago, Chile

7
Marcelo Kogan

Academico

Quimica Farmacologica y Toxicologica

UNIVERSIDAD DE CHILE, FACULTAD DE CIENCIAS QUÍMICAS Y FARMACÉUTICAS

Santiago, Chile

4
Sergio Lavandero

Director

Advanced Center for Chronic Diseases (ACCDiS)

UNIVERSIDAD DE CHILE, FAC CIENCIAS QUÍMICAS Y FARMACÉUTICAS

Santiago, Chile

4
Raúl Vivar

Profesor Asistente

Universidad de Chile

Santiago, Chile

3
Eyleen Araya

Academic

Chemical Sciences

Universidad Andres Bello

santiago, Chile

2
Pablo Aránguiz

Postdoctorado

Fisiología y Biofísica

Universidad de Chile

Santiago, Chile

2
Yenniffer Ávalos

Profesor Asistente

Departamento de Biología

Universidad de Santiago de Chile

Santiago, Chile

2
Lisette Leyton

Full Professor

Cell and Molecular Biology

FACULTAD DE MEDICINA UNIVERSIDAD DE CHILE

Santiago, Chile

2
Mario Chiong

Profesor

Departamento de Bioquímica y Biología Molecular

Universidad de Chile

Santiago, Chile

1
Lorena Garcia

Assistant Professor

Bioquimica y Biologia Molecular

UNIVERSIDAD DE CHILE

Santiago, Chile

1
Simon Guerrero

Investigador

Instituto de Investigación Interdisciplinar en Ciencias Biomédicas SEK

Universidad SEK

Santiago, Chile

1
Claudia Muñoz

Postdoctorado

Universidad de Chile

Santiago, Chile

1
Ariel Contreras

assistance professor

Institute for Research in Dental Science

UNIVERSIDAD DE CHILE

Santiago, Chile

1
Pedro Toledo

Profesor Titular

Departamento Ingeniería Química

UNIVERSIDAD DE CONCEPCIÓN - DEPARTAMENTO DE INGENIERÍA QUÍMICA

Concepción, Chile