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Raúl Fabián Vivar Sánchez

Profesor Asistente

Universidad de Chile

Santiago, Chile

Farmacología Cardiovascular; Fibrosis Cardiaca; Estrés metabólico y diabetes; Biología molecular; Señalización celular

Farmacología, UNIVERSIDAD DE CHILE. Chile, 2012
Químico Farmaceútico, UNIVERSIDAD DE CHILE. Chile, 2007

Profesor Asistente Full Time

UNIVERSIDAD DE CHILE

Medicina

Santiago, Chile

2016 - A la fecha


Role of FoxO3a as a negative regulator of the cardiac myofibroblast conversion induced by TGF-?1 Humeres, C.; Bolivar S. Article ISI SCOPUS Biochimica et Biophysica Acta - Molecular Cell Research (2020)
TGF-beta 1 induced up-regulation of B1 kinin receptor promotes antifibrotic activity in rat cardiac myofibroblasts Ayala, Pedro Article ISI SCOPUS MOLECULAR BIOLOGY REPORTS (2019)
The Association of Ascorbic Acid, Deferoxamine and N-Acetylcysteine Improves Cardiac Fibroblast Viability and Cellular Function Associated with Tissue Repair Damaged by Simulated Ischemia/Reperfusion Riquelme, J. A.; Leiva-Navarrete S.; Cayupi-Vivanco J.; Espinoza-PÃ©rez C.; Ruz-CortÃ©s F. Article ISI SCOPUS ANTIOXIDANTS (2019)
Acute lung injury by gastric fluid instillation: activation of myofibroblast apoptosis during injury resolution Ayala, P; Vivar, R; Olmos, P; Martin, TS; Borzone, GR Article ISI SCOPUS RESPIRATORY RESEARCH (2018)
Changes in the pattern of fibrosis in the rat lung with repetitive orotracheal instillations of gastric contents=> evidence of persistent collagen accumulation. Ayala, Pedro; Torres, Jorge; Vivar, Raúl; Olmos, Pablo R; Meneses, Manuel; Borzone, Gisella R Article American journal of physiology. Lung cellular and molecular physiology (2018)
Elastin degradation products in acute lung injury induced by gastric contents aspiration. Ayala, Pedro; Vivar, Raúl; Montalva, Rebeca; Olmos, Pablo; Meneses, Manuel; Borzone, Gisella R Article Respiratory research (2018)
Expression and function of TLR4-induced B1R bradykinin receptor on cardiac fibroblasts Munoz-Rodriguez, Claudia; Fernandez, Samuel; Miguel Osorio, Jose; Olivares, Francisco; Vivar, Raul; Hemmings, Karen E.; Turner, Neil A. Article ISI SCOPUS TOXICOLOGY AND APPLIED PHARMACOLOGY (2018)
Heparan sulfate potentiates leukocyte adhesion on cardiac fibroblast by enhancing Vcam-1 and Icam-1 expression Aranguiz, Pablo; Vivar, Raul Article ISI SCOPUS BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (2018)
IFN-beta Plays Both Pro- and Anti-inflammatory Roles in the Rat Cardiac Fibroblast Through Differential STAT Protein Activation Vivar, Raul Article ISI SCOPUS FRONTIERS IN PHARMACOLOGY (2018)
Lipopolysaccharide Activates Toll-Like Receptor 4 and Prevents Cardiac Fibroblast-to-Myofibroblast Differentiation. Bolívar, Samir; Santana, Roxana; Ayala, Pedro; Landaeta, Rodolfo; Boza, Pía; Humeres, Claudio; Vivar, Raúl; Muñoz, Claudia; Pardo, Viviana; Fernandez, Samuel; Anfossi, Renatto; Diaz-Araya, Guillermo Article Cardiovascular toxicology (2017)
Transforming growth factor-beta and Forkhead box O transcription factors as cardiac fibroblast regulators. Norambuena-Soto, Ignacio; Núñez-Soto, Constanza; Sanhueza-Olivares, Fernanda; Cancino-Arenas, Nicole; Mondaca-Ruff, David; Vivar, Raul; Díaz-Araya, Guillermo; Mellado, Rosemarie; Chiong, Mario Article Bioscience trends (2017)
Cardiac fibroblast cytokine profiles induced by proinflammatory or profibrotic stimuli promote monocyte recruitment and modulate macrophage M1/M2 balance in vitro. Humeres, Claudio; Vivar, Raúl; Boza, Pia; Muñoz, Claudia; Bolivar, Samir; Anfossi, Renatto; Osorio, Jose Miguel; Olivares-Silva, Francisco; García, Lorena; Díaz-Araya, Guillermo Article Journal of molecular and cellular cardiology (2016)
Expression and function of toll-like receptor 4 and inflammasomes in cardiac fibroblasts and myofibroblasts: IL-1 beta synthesis, secretion, and degradation Boza P.; Ayala, P; Vivar, R; Humeres, C.; Cáceres F.T.; Munoz, C; Garcia, L.; Hermoso M.A. Article ISI SCOPUS MOLECULAR IMMUNOLOGY (2016)
FoxO1 mediates TGF-beta1-dependent cardiac myofibroblast differentiation Vivar, R; Humeres, C.; Munoz, C; Boza P.; Bolivar S.; Tapia, F; Lavandero S.; Chiong M.; Diaz-Araya, G Article ISI SCOPUS BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH (2016)
4-Phenylbutyric acid prevent cytotoxicity induced by thapsigargin in rat cardiac fibroblast Humeres, C.; Montenegro, J.; Varela, M.; Ayala, P; Vivar, R; Letelier, A; Olmedo, I; Catalán M.; Rivas, C; Baeza, P; et al. Article ISI SCOPUS TOXICOLOGY IN VITRO (2014)
EPAC expression and function in cardiac fibroblasts and myofibroblasts Olmedo, I; Munoz, C; Guzmán N.; Catalán M.; Vivar, R; Ayala, P; Humeres, C.; Aranguiz, P; Garcia, L.; Velarde, V; et al. Article ISI SCOPUS Toxicology and Applied Pharmacology (2013)
TGF-beta 1 prevents simulated ischemia/reperfusion-induced cardiac fibroblast apoptosis by activation of both canonical and non-canonical signaling pathways Vivar, R; Humeres, C.; Ayala, P; Olmedo, I; Catalán M.; Garcia, L.; Lavandero S.; Diaz-Araya, G Article ISI SCOPUS Biochimica et Biophysica Acta - Molecular Basis of Disease (2013)
Attenuation of endoplasmic reticulum stress using the chemical chaperone 4-phenylbutyric acid prevents cardiac fibrosis induced by isoproterenol Ayala, P; Montenegro, J.; Vivar, R; Letelier, A; Urroz P.A.; Copaja M; Pivet, D; Humeres, C.; Troncoso R.; Vicencio J.M.; et al. Article ISI SCOPUS Experimental and Molecular Pathology (2012)
Cardiac fibroblast death by ischemia/reperfusion is partially inhibited by IGF-1 through both PI3K/Akt and MEK-ERK pathways Vivar, R; Humeres, C.; Varela, M.; Ayala, P; Guzmán N.; Olmedo, I; Catalán M.; Boza P.; Munoz, C; Diaz-Araya, G Article ISI SCOPUS Experimental and Molecular Pathology (2012)
Differential regulation of collagen secretion by kinin receptors in cardiac fibroblast and myofibroblast Catalán M.; Smolic, C; Contreras, A; Ayala, P; Olmedo, I; Copaja M; Boza P.; Vivar, R; Avalos, Y; Lavandero S.; et al. Article ISI SCOPUS Toxicology and Applied Pharmacology (2012)
Simvastatin disrupts cytoskeleton and decreases cardiac fibroblast adhesion, migration and viability Copaja M; Venegas, D; Aranguiz, P; Canales, J; Vivar, R; Avalos, Y; Garcia, L.; Chiong M.; Olmedo, I; Catalán M.; et al. Article ISI SCOPUS Toxicology (2012)
Simvastatin induces apoptosis by a Rho-dependent mechanism in cultured cardiac fibroblasts and myofibroblasts Copaja M; Venegas, D; Aranguiz, P; Canales, J; Vivar, R; Catalán M.; Olmedo, I; Rodríguez, AE; Chiong M.; Leyton, L.; et al. Article ISI SCOPUS Toxicology and Applied Pharmacology (2011)
Early expression of monocyte chemoattractant protein-1 correlates with the onset of isoproterenol-induced cardiac fibrosis in rats with distinct angiotensin-converting enzyme polymorphism Copaja Soto M, Valenzuela R, Saldaña A, Paz Ocaranza M, Jalil JE, Vio C, Lijnen P, Ordenes GE, Vivar Sanchez R, Lavandero S, Díaz-Araya G. Article J Renin Angiotensin Aldosterone Syst (2008)
Inflamación y disfunción endotelial en pacientes con insuficiencia cardiaca crónica Greig, Douglas; Castro, Pablo; Gabrielli, Luigi; Miranda, Rodrigo; Verdejo, Hugo; Alcaino, Hernan; Bustos, Carlos; Chiong, Mario; Godoy, Ivan; Mellado, Rosemarie; et al. Article SCIELO REVISTA MEDICA DE CHILE (2008)
Inflammation and endothelial dysfunction in patients with chronic heart failure greig d.; Castro P. ; Gabrielli, L; Miranda, R.; Verdejo H.; Alcaino H; Bustos C.; Chiong M.; Godoy, I.; Mellado R.; et al. Article ISI REVISTA MEDICA DE CHILE (2008)
Phospholipase C/protein kinase C pathway mediates angiotensin II-dependent apoptosis in neonatal rat cardiac fibroblasts expressing AT1 receptor Vivar, R; Soto C.; Copaja M; Mateluna, F; Aranguiz, P; Munoz, JP; Chiong M.; Garcia, L.; Letelier, A; Thomas, WG; et al. Article ISI SCOPUS JOURNAL OF CARDIOVASCULAR PHARMACOLOGY (2008)


Resolvins D1 and E1 novel pharmacological targets to prevent hypertension-dependent cardiac fibrosis=> a focus on cardiac fibroblast pro-inflammatory role FONDECYT (1170425) Proyecto 2017-2021 Coinvestigador(a)
HYPERGLYCEMIA REQUIRES FOXO1, CTGF AND TGF-?1 TO INDUCE A PROFIBROTIC AND PROINFLAMMATORY PHENOTYPE IN CARDIAC FIBROBLASTS=> NEW ANTIDIABETIC ROLE OF LIPOXINA4. FONDECYT (11160531) Proyecto 2016-2019 Inv. Responsable
Myofibroblast in the lung after instillation of whole gastric juice in a rat model=> A normal reparative process or a starting point for the development of chronic fibrosis? FONDECYT (11140913) Proyecto 2014-2017 Personal técnico y/o de apoyo
Role of TLR4 and inflammasome in the differentiation and acquisition of a proinflammatory phenotype of adult rat cardiac myofibroblast FONDECYT (1130300) Proyecto 2013-2015 Personal técnico y/o de apoyo
LA REGULACION DIFERENCIAL DE FOXO1 Y FOXO3A POR TGF-BETA1, MODULA TANTO LA DIFERENCIACION COMO EL AUMENTO DE LA ACTIVIDAD ANTIAPOPTOTICA/ANTIOXIDANTE DE FIBROBLASTOS CARDIACOS FONDECYT (3130657) Proyecto 2012-2015 Inv. Responsable
TGF-beta1 inhibe la apoptosis de fibroblastos cardiacos sometidos a isquemia/reperfusión simulada, a través de la activación de las vías canónica y no canónica PFCHA (21080518) Proyecto 2008-2012 Inv. Responsable


Cardiac fibroblasts as sentinel cells in cardiac tissue: Receptors, signaling pathways and cellular functions Diaz-Araya, G; Vivar, R; Humeres, C.; Boza P.; Bolivar S.; Munoz, C Review ISI SCOPUS Pharmacological Research (2015)

Marcela Hermoso

Full Professor

School of Medicine

UNIVERSIDAD DE CHILE

Santiago, Chile

Guillermo Díaz

Académico

Química Farmacológica y Toxicológica

UNIVERSIDAD DE CHILE, FACULTAD DE CIENCIAS QUÍMICAS Y FARMACÉUTICAS

Santiago, Chile

SERGIO LAVANDERO

Director

Advanced Center for Chronic Diseases (ACCDiS)

UNIVERSIDAD DE CHILE, FAC CIENCIAS QUÍMICAS Y FARMACÉUTICAS

Santiago, Chile

Mario Chiong

Profesor

Departamento de Bioquímica y Biología Molecular

Universidad de Chile

Santiago, Chile

Rosemarie Mellado

Jefe de carrera / Académica

Farmacia

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

Patricio Baeza

adjunt profesor

PONTIFICIA UNIVERSIDAD CATOLICA DE VALPARAISO

Valparaiso, Chile

Lorena Garcia

Assistant Professor

Bioquimica y Biologia Molecular

UNIVERSIDAD DE CHILE

Santiago, Chile

Rodrigo Troncoso

Assistant professor

Universidad de Chile, Instituto de Nutrición y Tecnología de los Alimentos

Santiago de Chile, Chile

Lisette Leyton

Full Professor

Cell and Molecular Biology

FACULTAD DE MEDICINA UNIVERSIDAD DE CHILE

Santiago, Chile

Raúl Vivar

Profesor Asistente

Universidad de Chile

Santiago, Chile

Ariel Contreras

assistance professor

Institute for Research in Dental Science

UNIVERSIDAD DE CHILE

Santiago, Chile

Jaime Riquelme

Assistant Professor

Química Farmacológica y Toxicológica

Universidad de Chile

Santiago, Chile

Pablo Aránguiz

Jefe de Carrera

Escuela de Ciencias de la Salud

Universidad Vina del Mar

Viña del Mar, Chile

Luigi Gabrielli

Profesor Asistente

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

Chile

Yenniffer Ávalos

Profesor Asistente

Departamento de Biología

Universidad de Santiago de Chile

Santiago, Chile

Ivonne Olmedo

Assistant Profesor

Programa de Fisiopatología

Universidad de Chile

Santiago, Chile

Rodrigo Troncoso

Associate Professor

Instituto de Nutrición y Tecnología de los Alimentos

Santiago, Chile

Zully Pedrozo

Associated Professor

Physiology and Biophysical

Universidad de Chile

SANTIAGO DE CHILE, Chile

Hugo Verdejo

Profesor Asociado

División de Enferemedades Cardiovasculares

Pontificia Universidad Católica de Chile

Santiago, Chile

Daniela Salas

Renatto Anfossi

Coordinador de Investigación

Unidad de Investigación

Hospital Regional Libertador Bernardo O'Higgins

Rancagua, Chile

Francisco Olivares

Pharmacology PhD(c)

Department of Pharmaceutical and Toxicological Chemistry

Universidad de Chile

Santiago, Chile

Paula Valenzuela

Senior Researcher

Nuevos Materiales Avanzados

Leitat Chile

Santiago, Chile

Douglas Greig

Médico Jefe

Cardiología

P. Universidad Católica de Chile

Santiago, Chile

Pedro Ayala

Profesor investigador asistente

Departamento de Enfermedades Respiratorias

Pontificia Universidad Católica de Chile

Santiago, Chile

Claudia Muñoz

Postdoctorado

Universidad de Chile

Santiago, Chile

Viviana Pardo

Profesional docente

Química Farmacológica y Toxicológica

Universidad de Chile

Santiago, Chile

Pablo Castro

JEFE DIVISION

DIVISION ENFERMEDADES CARDIOVASCULARES

Pontificia Universidad Católica de Chile

SANTIAGO, Chile

Sebastián Leiva

Lab Manager

Bioquímica y Biología Molecular

Universidad de Chile

Santiago, Chile

Raúl Fabián Vivar Sánchez

Líneas de Investigación

Educación

Farmacología, UNIVERSIDAD DE CHILE. Chile, 2012

Químico Farmaceútico, UNIVERSIDAD DE CHILE. Chile, 2007

Experiencia Académica

Profesor Asistente Full Time

Article (26)

Proyecto (6)

Resolvins D1 and E1 novel pharmacological targets to prevent hypertension-dependent cardiac fibrosis=> a focus on cardiac fibroblast pro-inflammatory role

HYPERGLYCEMIA REQUIRES FOXO1, CTGF AND TGF-?1 TO INDUCE A PROFIBROTIC AND PROINFLAMMATORY PHENOTYPE IN CARDIAC FIBROBLASTS=> NEW ANTIDIABETIC ROLE OF LIPOXINA4.

Myofibroblast in the lung after instillation of whole gastric juice in a rat model=> A normal reparative process or a starting point for the development of chronic fibrosis?

Role of TLR4 and inflammasome in the differentiation and acquisition of a proinflammatory phenotype of adult rat cardiac myofibroblast

LA REGULACION DIFERENCIAL DE FOXO1 Y FOXO3A POR TGF-BETA1, MODULA TANTO LA DIFERENCIACION COMO EL AUMENTO DE LA ACTIVIDAD ANTIAPOPTOTICA/ANTIOXIDANTE DE FIBROBLASTOS CARDIACOS

TGF-beta1 inhibe la apoptosis de fibroblastos cardiacos sometidos a isquemia/reperfusión simulada, a través de la activación de las vías canónica y no canónica

Review (1)