Man

Raúl Fabián Vivar Sánchez

Profesor Asistente

Universidad de Chile

Santiago, Chile

Líneas de Investigación


Farmacología Cardiovascular; Fibrosis Cardiaca; Estrés metabólico y diabetes; Biología molecular; Señalización celular

Educación

  •  Farmacología, UNIVERSIDAD DE CHILE. Chile, 2012
  •  Químico Farmaceútico, UNIVERSIDAD DE CHILE. Chile, 2007

Experiencia Académica

  •   Profesor Asistente Full Time

    UNIVERSIDAD DE CHILE

    Medicina

    Santiago, Chile

    2016 - A la fecha


 

Article (20)

Role of FoxO3a as a negative regulator of the cardiac myofibroblast conversion induced by TGF-beta 1

Humeres, C.; Bolivar, S

Article ISI SCOPUS
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH  (2020)

TGF-beta 1 induced up-regulation of B1 kinin receptor promotes antifibrotic activity in rat cardiac myofibroblasts

Ayala, Pedro

Article ISI SCOPUS
MOLECULAR BIOLOGY REPORTS  (2019)

The Association of Ascorbic Acid, Deferoxamine and N-Acetylcysteine Improves Cardiac Fibroblast Viability and Cellular Function Associated with Tissue Repair Damaged by Simulated Ischemia/Reperfusion

Riquelme, J. A.; Leiva-Navarrete S.; Cayupi-Vivanco J.; Espinoza-Pérez C.; Ruz-Cortés F.

Article ISI SCOPUS
ANTIOXIDANTS  (2019)

Acute lung injury by gastric fluid instillation: activation of myofibroblast apoptosis during injury resolution

Ayala, P; Vivar, R; Olmos, P; Martin, TS; Borzone, GR

Article ISI SCOPUS
RESPIRATORY RESEARCH  (2018)

Expression and function of TLR4-induced B1R bradykinin receptor on cardiac fibroblasts

Munoz-Rodriguez, Claudia; Fernandez, Samuel; Miguel Osorio, Jose; Olivares, Francisco; Vivar, Raul; Hemmings, Karen E.; Turner, Neil A.

Article ISI SCOPUS
TOXICOLOGY AND APPLIED PHARMACOLOGY  (2018)

Heparan sulfate potentiates leukocyte adhesion on cardiac fibroblast by enhancing Vcam-1 and Icam-1 expression

Aranguiz, Pablo; Vivar, Raul

Article ISI SCOPUS
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE  (2018)

IFN-beta Plays Both Pro- and Anti-inflammatory Roles in the Rat Cardiac Fibroblast Through Differential STAT Protein Activation

Vivar, Raul

Article ISI SCOPUS
FRONTIERS IN PHARMACOLOGY  (2018)

Expression and function of toll-like receptor 4 and inflammasomes in cardiac fibroblasts and myofibroblasts: IL-1 beta synthesis, secretion, and degradation

Boza P.; Ayala, P; Vivar, R; Humeres, C.; Cáceres F.T.; Munoz, C; Garcia, L; Hermoso, MA

Article ISI SCOPUS
MOLECULAR IMMUNOLOGY  (2016)

FoxO1 mediates TGF-beta1-dependent cardiac myofibroblast differentiation

Vivar, R; Humeres, C.; Munoz, C; Boza P.; Bolivar, S; Tapia, F; Lavandero, S; Chiong, M; Díaz-Araya, G

Article ISI SCOPUS
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH  (2016)

4-Phenylbutyric acid prevent cytotoxicity induced by thapsigargin in rat cardiac fibroblast

Humeres, C.; Montenegro, J; Varela, M; Ayala, P; Vivar, R; Letelier, A; Olmedo, I; Catalán, M; Rivas, C; Baeza, P; et al.

Article ISI SCOPUS
TOXICOLOGY IN VITRO  (2014)

EPAC expression and function in cardiac fibroblasts and myofibroblasts

Olmedo, I; Munoz, C; Guzmán, N; Catalán, M; Vivar, R; Ayala, P; Humeres, C.; Aránguiz, P; Garcia, L; Velarde, V; et al.

Article ISI SCOPUS
Toxicology and Applied Pharmacology  (2013)

TGF-beta 1 prevents simulated ischemia/reperfusion-induced cardiac fibroblast apoptosis by activation of both canonical and non-canonical signaling pathways

Vivar, R; Humeres, C.; Ayala, P; Olmedo, I; Catalán, M; Garcia, L; Lavandero, S; Díaz-Araya, G

Article ISI SCOPUS
Biochimica et Biophysica Acta - Molecular Basis of Disease  (2013)

Attenuation of endoplasmic reticulum stress using the chemical chaperone 4-phenylbutyric acid prevents cardiac fibrosis induced by isoproterenol

Ayala, P; Montenegro, J; Vivar, R; Letelier, A; Urroz P.A.; Copaja M; Pivet, D; Humeres, C.; Troncoso, R; Vicencio J.M.; et al.

Article ISI SCOPUS
Experimental and Molecular Pathology  (2012)

Cardiac fibroblast death by ischemia/reperfusion is partially inhibited by IGF-1 through both PI3K/Akt and MEK-ERK pathways

Vivar, R; Humeres, C.; Varela, M; Ayala, P; Guzmán, N; Olmedo, I; Catalán, M; Boza P.; Munoz, C; Díaz-Araya, G

Article ISI SCOPUS
Experimental and Molecular Pathology  (2012)

Differential regulation of collagen secretion by kinin receptors in cardiac fibroblast and myofibroblast

Catalán, M; Smolic, C; Contreras, A; Ayala, P; Olmedo, I; Copaja M; Boza P.; Vivar, R; Avalos, Y; Lavandero, S; et al.

Article ISI SCOPUS
Toxicology and Applied Pharmacology  (2012)

Simvastatin disrupts cytoskeleton and decreases cardiac fibroblast adhesion, migration and viability

Copaja M; Venegas, D; Aránguiz, P; Canales, J; Vivar, R; Avalos, Y; Garcia, L; Chiong, M; Olmedo, I; Catalán, M; et al.

Article ISI SCOPUS
Toxicology  (2012)

Simvastatin induces apoptosis by a Rho-dependent mechanism in cultured cardiac fibroblasts and myofibroblasts

Copaja M; Venegas, D; Aránguiz, P; Canales, J; Vivar, R; Catalán, M; Olmedo, I; Rodríguez, AE; Chiong, M; Leyton, L; et al.

Article ISI SCOPUS
Toxicology and Applied Pharmacology  (2011)

Inflamación y disfunción endotelial en pacientes con insuficiencia cardiaca crónica

Greig, Douglas; Castro, Pablo; Gabrielli, Luigi; Miranda, Rodrigo; Verdejo, Hugo; Alcaino, Hernan; Bustos, Carlos; Chiong, Mario; Godoy, Ivan; Mellado, Rosemarie; et al.

Article SCIELO
REVISTA MEDICA DE CHILE  (2008)

Inflammation and endothelial dysfunction in patients with chronic heart failure

Greig, D; Castro, P; Gabrielli, L; Miranda, R; Verdejo, H; Alcaino H; Bustos, C; Chiong, M; Godoy, I; Mellado, R; et al.

Article ISI
REVISTA MEDICA DE CHILE  (2008)

Phospholipase C/protein kinase C pathway mediates angiotensin II-dependent apoptosis in neonatal rat cardiac fibroblasts expressing AT1 receptor

Vivar, R; Soto, C; Copaja M; Mateluna, F; Aránguiz, P; Muñoz, JP; Chiong, M; Garcia, L; Letelier, A; Thomas, WG; et al.

Article ISI SCOPUS
JOURNAL OF CARDIOVASCULAR PHARMACOLOGY  (2008)

Review (1)

Cardiac fibroblasts as sentinel cells in cardiac tissue: Receptors, signaling pathways and cellular functions

Díaz-Araya, G; Vivar, R; Humeres, C.; Boza P.; Bolivar, S; Munoz, C

Review ISI SCOPUS
Pharmacological Research  (2015)

1
Marcela Hermoso

Full Professor

School of Medicine

UNIVERSIDAD DE CHILE

Santiago, Chile

5
Guillermo Díaz

Académico

Química Farmacológica y Toxicológica

UNIVERSIDAD DE CHILE, FACULTAD DE CIENCIAS QUÍMICAS Y FARMACÉUTICAS

Santiago, Chile

12
SERGIO LAVANDERO

Director

Advanced Center for Chronic Diseases (ACCDiS)

UNIVERSIDAD DE CHILE, FAC CIENCIAS QUÍMICAS Y FARMACÉUTICAS

Santiago, Chile

6
Mario Chiong

Profesor

Departamento de Bioquímica y Biología Molecular

Universidad de Chile

Santiago, Chile

2
Rosemarie Mellado

Jefe de carrera / Académica

Farmacia

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

1
Patricio Baeza

adjunt profesor

PONTIFICIA UNIVERSIDAD CATOLICA DE VALPARAISO

Valparaiso, Chile

7
Lorena Garcia

Assistant Professor

Bioquimica y Biologia Molecular

UNIVERSIDAD DE CHILE

Santiago, Chile

1
Rodrigo Troncoso

Assistant professor

Universidad de Chile, Instituto de Nutrición y Tecnología de los Alimentos

Santiago de Chile, Chile

2
Lisette Leyton

Full Professor

Núcleo Interdisciplinario Biología y Genética

FACULTAD DE MEDICINA UNIVERSIDAD DE CHILE

Santiago, Chile

1
Francisco Tapia

Investigador

Intihuasi

INSTITUTO DE INVESTIGACIONES AGROPECUARIAS (INIA)

La Serena, Chile

21
Raúl Vivar

Profesor Asistente

Universidad de Chile

Santiago, Chile

1
Ariel Contreras

assistance professor

Institute for Research in Dental Science

UNIVERSIDAD DE CHILE

Santiago, Chile

1
Jaime Riquelme

Assistant Professor

Química Farmacológica y Toxicológica

Universidad de Chile

Santiago, Chile

7
Pablo Aránguiz

Jefe de Carrera

Escuela de Ciencias de la Salud

Universidad Vina del Mar

Viña del Mar, Chile

1
Luigi Gabrielli

Profesor Asistente

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

Chile

2
Yenniffer Ávalos

Profesor Asistente

Departamento de Biología

Universidad de Santiago de Chile

Santiago, Chile

4
Ivonne Olmedo

Assistant Profesor

Programa de Fisiopatología

Universidad de Chile

Santiago, Chile

1
Rodrigo Troncoso

Associate Professor

Instituto de Nutrición y Tecnología de los Alimentos

Santiago, Chile

1
Zully Pedrozo

Associated Professor

Physiology and Biophysical

Universidad de Chile

SANTIAGO DE CHILE, Chile

2
Hugo Verdejo

Profesor Asociado

División de Enferemedades Cardiovasculares

Pontificia Universidad Católica de Chile

Santiago, Chile

2
Daniela Salas

5
Renatto Anfossi

Jefe de Investigación

Departamento de Investigación

Hospital Regional Libertador Bernardo O'Higgins

Rancagua, Chile

3
Francisco Olivares

Pharmacology PhD(c)

Department of Pharmaceutical and Toxicological Chemistry

Universidad de Chile

Santiago, Chile

1
Paula Valenzuela

Senior Researcher

Nuevos Materiales Avanzados

Leitat Chile

Santiago, Chile

2
Douglas Greig

Médico Jefe

Cardiología

P. Universidad Católica de Chile

Santiago, Chile

1
Pedro Ayala

Profesor investigador asistente

Departamento de Enfermedades Respiratorias

Pontificia Universidad Católica de Chile

Santiago, Chile

9
Claudia Muñoz

Postdoctorado

Universidad de Chile

Santiago, Chile

1
Viviana Pardo

Profesional docente

Química Farmacológica y Toxicológica

Universidad de Chile

Santiago, Chile

1
Pablo Castro

JEFE DIVISION

DIVISION ENFERMEDADES CARDIOVASCULARES

Pontificia Universidad Católica de Chile

SANTIAGO, Chile

1
Sebastián Leiva

Lab Manager

Bioquímica y Biología Molecular

Universidad de Chile

Santiago, Chile