Man

Raúl Fabián Vivar Sánchez

Profesor Asistente

Universidad de Chile

Santiago, Chile

Líneas de Investigación


Farmacología Cardiovascular; Fibrosis Cardiaca; Estrés metabólico y diabetes; Biología molecular; Señalización celular

Educación

  •  Farmacología, UNIVERSIDAD DE CHILE. Chile, 2012
  •  Químico Farmaceútico, UNIVERSIDAD DE CHILE. Chile, 2007

Experiencia Académica

  •   Profesor Asistente Full Time

    UNIVERSIDAD DE CHILE

    Medicina

    Santiago, Chile

    2016 - A la fecha


 

Article (26)

Role of FoxO3a as a negative regulator of the cardiac myofibroblast conversion induced by TGF-?1
TGF-beta 1 induced up-regulation of B1 kinin receptor promotes antifibrotic activity in rat cardiac myofibroblasts
The Association of Ascorbic Acid, Deferoxamine and N-Acetylcysteine Improves Cardiac Fibroblast Viability and Cellular Function Associated with Tissue Repair Damaged by Simulated Ischemia/Reperfusion
Acute lung injury by gastric fluid instillation: activation of myofibroblast apoptosis during injury resolution
Changes in the pattern of fibrosis in the rat lung with repetitive orotracheal instillations of gastric contents=> evidence of persistent collagen accumulation.
Elastin degradation products in acute lung injury induced by gastric contents aspiration.
Expression and function of TLR4-induced B1R bradykinin receptor on cardiac fibroblasts
Heparan sulfate potentiates leukocyte adhesion on cardiac fibroblast by enhancing Vcam-1 and Icam-1 expression
IFN-beta Plays Both Pro- and Anti-inflammatory Roles in the Rat Cardiac Fibroblast Through Differential STAT Protein Activation
Lipopolysaccharide Activates Toll-Like Receptor 4 and Prevents Cardiac Fibroblast-to-Myofibroblast Differentiation.
Transforming growth factor-beta and Forkhead box O transcription factors as cardiac fibroblast regulators.
Cardiac fibroblast cytokine profiles induced by proinflammatory or profibrotic stimuli promote monocyte recruitment and modulate macrophage M1/M2 balance in vitro.
Expression and function of toll-like receptor 4 and inflammasomes in cardiac fibroblasts and myofibroblasts: IL-1? synthesis, secretion, and degradation
FoxO1 mediates TGF-beta1-dependent cardiac myofibroblast differentiation
4-Phenylbutyric acid prevent cytotoxicity induced by thapsigargin in rat cardiac fibroblast
EPAC expression and function in cardiac fibroblasts and myofibroblasts
TGF-beta 1 prevents simulated ischemia/reperfusion-induced cardiac fibroblast apoptosis by activation of both canonical and non-canonical signaling pathways
Attenuation of endoplasmic reticulum stress using the chemical chaperone 4-phenylbutyric acid prevents cardiac fibrosis induced by isoproterenol
Cardiac fibroblast death by ischemia/reperfusion is partially inhibited by IGF-1 through both PI3K/Akt and MEK-ERK pathways
Differential regulation of collagen secretion by kinin receptors in cardiac fibroblast and myofibroblast
Simvastatin disrupts cytoskeleton and decreases cardiac fibroblast adhesion, migration and viability
Simvastatin induces apoptosis by a Rho-dependent mechanism in cultured cardiac fibroblasts and myofibroblasts
Early expression of monocyte chemoattractant protein-1 correlates with the onset of isoproterenol-induced cardiac fibrosis in rats with distinct angiotensin-converting enzyme polymorphism
Inflamación y disfunción endotelial en pacientes con insuficiencia cardiaca crónica
Inflammation and endothelial dysfunction in patients with chronic heart failure
Phospholipase C/protein kinase C pathway mediates angiotensin II-dependent apoptosis in neonatal rat cardiac fibroblasts expressing AT1 receptor

Proyecto (6)

Resolvins D1 and E1 novel pharmacological targets to prevent hypertension-dependent cardiac fibrosis=> a focus on cardiac fibroblast pro-inflammatory role
HYPERGLYCEMIA REQUIRES FOXO1, CTGF AND TGF-?1 TO INDUCE A PROFIBROTIC AND PROINFLAMMATORY PHENOTYPE IN CARDIAC FIBROBLASTS=> NEW ANTIDIABETIC ROLE OF LIPOXINA4.
Myofibroblast in the lung after instillation of whole gastric juice in a rat model=> A normal reparative process or a starting point for the development of chronic fibrosis?
Role of TLR4 and inflammasome in the differentiation and acquisition of a proinflammatory phenotype of adult rat cardiac myofibroblast
LA REGULACION DIFERENCIAL DE FOXO1 Y FOXO3A POR TGF-BETA1, MODULA TANTO LA DIFERENCIACION COMO EL AUMENTO DE LA ACTIVIDAD ANTIAPOPTOTICA/ANTIOXIDANTE DE FIBROBLASTOS CARDIACOS
TGF-beta1 inhibe la apoptosis de fibroblastos cardiacos sometidos a isquemia/reperfusión simulada, a través de la activación de las vías canónica y no canónica

Review (1)

Cardiac fibroblasts as sentinel cells in cardiac tissue: Receptors, signaling pathways and cellular functions
21
Raúl Vivar

Profesor Asistente

Universidad de Chile

Santiago, Chile

12
Sergio Lavandero

Director

Advanced Center for Chronic Diseases (ACCDiS)

UNIVERSIDAD DE CHILE, FAC CIENCIAS QUÍMICAS Y FARMACÉUTICAS

Santiago, Chile

9
Claudia Muñoz

Postdoctorado

Universidad de Chile

Santiago, Chile

7
Lorena Garcia

Assistant Professor

Bioquimica y Biologia Molecular

UNIVERSIDAD DE CHILE

Santiago, Chile

6
Pablo Aránguiz

Postdoctorado

Fisiología y Biofísica

Universidad de Chile

Santiago, Chile

5
Mario Chiong

Profesor

Departamento de Bioquímica y Biología Molecular

Universidad de Chile

Santiago, Chile

5
Guillermo Díaz

Académico

Química Farmacológica y Toxicológica

UNIVERSIDAD DE CHILE, FACULTAD DE CIENCIAS QUÍMICAS Y FARMACÉUTICAS

Santiago, Chile

4
Ivonne Olmedo

Assistant Profesor

Programa de Fisiopatología

Universidad de Chile

Santiago, Chile

3
Francisco Olivares

Pharmacology PhD(c)

Department of Pharmaceutical and Toxicological Chemistry

Universidad de Chile

Santiago, Chile

2
Yenniffer Ávalos

Profesor Asistente

Departamento de Biología

Universidad de Santiago de Chile

Santiago, Chile

2
Douglas Greig

Médico Jefe

Cardiología

P. Universidad Católica de Chile

Santiago, Chile

2
Lisette Leyton

Full Professor

Cell and Molecular Biology

FACULTAD DE MEDICINA UNIVERSIDAD DE CHILE

Santiago, Chile

2
Rosemarie Mellado

Jefe de carrera / Académica

Farmacia

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

2
Hugo Verdejo

Profesor Asistente

División de Enferemedades Cardiovasculares

Pontificia Universidad Católica de Chile

Santiago, Chile

1
Rodrigo Troncoso

Associate Professor

Instituto de Nutrición y Tecnología de los Alimentos

Santiago, Chile

1
Mabel Catalán

Profesora Asistente

Instituto de Ciencias Biomédicas

Universidad de Chile

Santiago, Chile

1
Marcela Hermoso

Full Professor

School of Medicine

UNIVERSIDAD DE CHILE

Santiago, Chile

1
Patricio Baeza

adjunt profesor

PONTIFICIA UNIVERSIDAD CATOLICA DE VALPARAISO

Valparaiso, Chile

1
Luigi Gabrielli

Profesor Asistente

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

Chile

1
Rodrigo Troncoso

Assistant professor

Universidad de Chile, Instituto de Nutrición y Tecnología de los Alimentos

Santiago de Chile, Chile

1
Paula Valenzuela

Investigadora

Aintech SpA

Santiago, Chile

1
Ariel Contreras

assistance professor

Institute for Research in Dental Science

UNIVERSIDAD DE CHILE

Santiago, Chile

1
Pedro Ayala

Profesor investigador asistente

Departamento de Enfermedades Respiratorias

Pontificia Universidad Católica de Chile

Santiago, Chile

1
Viviana Pardo

Profesional docente

Química Farmacológica y Toxicológica

Universidad de Chile

Santiago, Chile

1
Pablo Castro

JEFE DIVISION

DIVISION ENFERMEDADES CARDIOVASCULARES

Pontificia Universidad Católica de Chile

SANTIAGO, Chile

1
Zully Pedrozo

Assistant professor

Physiology and Biophysical

Universidad de Chile

SANTIAGO DE CHILE, Chile