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Pedro Segundo Ayala Jeria

Profesor investigador asistente

Pontificia Universidad Católica de Chile

Santiago, Chile

Mecanismos fisiopatológicos de la reparación y fibrosis pulmonar después de daño inducido por aspiración de contenido digestivo en ratas. Daño pulmonar agudo Modelamiento de la micro mecánica pulmonar en ratas.

Farmacologia, UNIVERSIDAD DE CHILE. Chile, 2013
Químico Farmacéutico, UNIVERSIDAD DE CHILE. Chile, 2009
Docencia Universitaria, PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE. Chile, 2020
Gestión de estudios clínicos, PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE. Chile, 2021

Profesor Investigador Asistente Full Time

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

Facultad de Medicina

Santiago, Chile

2018 - A la fecha
Profesor asociado Part Time

Universidad Pedro de Valdivia

Facultad de ciencias de la salud

Chile

2013 - 2013
Apouo a la Investigacion Full Time

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

Facultad de Medicina

Chile

2013 - 2018


Toll-Like Receptor 4 Activation Prevents Rat Cardiac Fibroblast Death Induced by Simulated Ischemia/Reperfusion Parra-Flores, Pablo; Espitia-Corredor, Jenaro; Espinoza-Perez, Claudio; Queirolo, Cristian; Ayala, Pedro; Bruggendieck, Francisca; Salas-Hernandez, Aimee; Pardo-Jimenez, Viviana; Diaz-Araya, Guillermo Article ISI Frontiers in cardiovascular medicine (2021)
Near-Apneic Ventilation Decreases Lung Injury and Fibroproliferation in an Acute Respiratory Distress Syndrome Model with Extracorporeal Membrane Oxygenation Araos, Joaquin; Alegria, Leyla; Garcia, Patricio; Cruces, Pablo.; Soto, Dagoberto.; Erranz, Benjamin; Amthauer, Macarena; Salomon, Tatiana; Medina, Tania; Rodriguez, Felipe; Ayala, Pedro; Borzone, Gisella R.; Meneses, Manuel; Damiani, Felipe; Retamal, Jaime.; Cornejo, Rodrigo; Bugedo, Guillermo.; Bruhn, Alejandro. Article ISI SCOPUS AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2019)
TGF-beta 1 induced up-regulation of B1 kinin receptor promotes antifibrotic activity in rat cardiac myofibroblasts Catalán, Mabel; Aránguiz, Pablo; Boza, Pía; Olmedo, Ivonne; Humeres, Claudio; Vivar, Raúl; Anfossi, Renatto; Ayala, Pedro; Espinoza, Claudio; Lavandero, Sergio; Díaz-Araya, Guillermo Article ISI SCOPUS MOLECULAR BIOLOGY REPORTS (2019)
Acute lung injury by gastric fluid instillation=> activation of myofibroblast apoptosis during injury resolution. Ayala, Pedro; Torres, Jorge; Vivar, Raúl; Meneses, Manuel; Olmos, Pablo; San Martin, Tamara; Borzone, Gisella R Article Respiratory research (2018)
Changes in the pattern of fibrosis in the rat lung with repetitive orotracheal instillations of gastric contents=> Evidence of persistent collagen accumulation. Ayala, Pedro; Torres, Jorge; Vivar, Raul; Olmos, Pablo R; Meneses, Manuel; Borzone, Gisella R Article American journal of physiology. Lung cellular and molecular physiology (2018)
Elastin degradation products in acute lung injury induced by gastric contents aspiration Ayala, P; Vivar, R; Montalva, R; Olmos, P; Meneses, M; Borzone, GR Article RESPIRATORY RESEARCH (2018)
Lipopolysaccharide Activates Toll-Like Receptor 4 and Prevents Cardiac Fibroblast-to-Myofibroblast Differentiation. Bolívar, Samir; Santana, Roxana; Ayala, Pedro; Landaeta, Rodolfo; Boza, Pía; Humeres, Claudio; Vivar, Raúl; Muñoz, Claudia; Pardo, Viviana; Fernandez, Samuel; Anfossi, Renatto; Diaz-Araya, Guillermo Article Cardiovascular toxicology (2017)
Acute lung injury induced by whole gastric fluid: hepatic acute phase response contributes to increase lung antiprotease protection. Ayala, Pedro; Meneses, Manuel; Olmos, Pablo; Montalva, Rebeca; Droguett, Karla; Ríos, Mariana; Borzone, Gisella Article Respiratory research (2016)
Expression and function of toll-like receptor 4 and inflammasomes in cardiac fibroblasts and myofibroblasts: IL-1Î² synthesis, secretion, and degradation. Boza, Pia; Ayala, Pedro; Vivar, Raúl; Humeres, Claudio; Cáceres, Felipe Tapia; Muñoz, Claudia; García, Lorena; Hermoso, Marcela A; Díaz-Araya, Guillermo Article Molecular immunology (2016)
Resolution of lung injury after a single event of aspiration: a model of bilateral instillation of whole gastric fluid. Araos, Joaquín D; Ayala, Pedro S; Meneses, Manuel; Contreras, Rafael; Cutiño, Andrea; Montalva, Rebeca M; Tazelaar, Henry D; Borzone, Gisella R Article The American journal of pathology (2015)
4-Phenylbutyric acid prevent cytotoxicity induced by thapsigargin in rat cardiac fibroblast Humeres C.; Montenegro J.; Varela M.; Ayala P.; Vivar R.; Letelier A.; Olmedo I.; Catalán M.; Rivas C.; Baeza P.; Muñoz C.; García L.; Lavandero S.; Diaz-Araya, G Article TOXICOLOGY IN VITRO (2014)
4-Phenylbutyric acid prevent cytotoxicity induced by thapsigargin in rat cardiac fibroblast. Humeres, C; Montenegro, J; Varela, M; Ayala, P; Vivar, R; Letelier, A; Olmedo, I; Catalán, M; Rivas, C; Baeza, P; Muñoz, C; García, L; Lavandero, S; Díaz-Araya, G Article Toxicology in vitro : an international journal published in association with BIBRA (2014)
A novel dihydropyridine with 3-aryl meta-hydroxyl substitution blocks L-type calcium channels in rat cardiomyocytes. Galvis-Pareja, David; Zapata-Torres, Gerald; Hidalgo, Jorge; Ayala, Pedro; Pedrozo, Zully; Ibarra, Cristián; Diaz-Araya, Guillermo; Hall, Andrew R; Vicencio, Jose Miguel; Nuñez-Vergara, Luis; Lavandero, Sergio Article Toxicology and applied pharmacology (2014)
Angiotensin-(1-9) reverses experimental hypertension and cardiovascular damage by inhibition of the angiotensin converting enzyme/Ang II axis Ocaranza, Maria Paz; Moya, Jackeline; Barrientos, Victor; Alzamora, Rodrigo; Hevia, Daniel; Morales, Cristobal; Pinto, Melissa; Escudero, Nicolas; Garcia, Lorena; Novoa, Ulises; Ayala, Pedro; Diaz-Araya, Guillermo; Godoy, Ivan; Chiong, Mario; Lavandero, Sergio; Jalil, Jorge E.; Michea, Luis Article ISI SCOPUS JOURNAL OF HYPERTENSION (2014)
EPAC expression and function in cardiac fibroblasts and myofibroblasts Olmedo I.; Muñoz C.; Guzmán N.; Catalán M.; Vivar R.; Ayala P.; Humeres C.; Aranguiz, P; García L.; Velarde V; Diaz-Araya, G Article TOXICOLOGY AND APPLIED PHARMACOLOGY (2013)
TGF-beta 1 prevents simulated ischemia/reperfusion-induced cardiac fibroblast apoptosis by activation of both canonical and non-canonical signaling pathways Vivar R.; Humeres C.; Ayala P.; Olmedo I.; Catalán M.; García L.; Lavandero S.; Diaz-Araya, G Article BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (2013)
Attenuation of endoplasmic reticulum stress using the chemical chaperone 4-phenylbutyric acid prevents cardiac fibrosis induced by isoproterenol. Ayala, Pedro; Montenegro, José; Vivar, Raúl; Letelier, Alan; Urroz, Pablo Aránguiz; Copaja, Miguel; Pivet, Deisy; Humeres, Claudio; Troncoso, Rodrigo; Vicencio, José Miguel; Lavandero, Sergio; Díaz-Araya, Guillermo Article Experimental and molecular pathology (2012)
Cardiac fibroblast death by ischemia/reperfusion is partially inhibited by IGF-1 through both PI3K/Akt and MEK-ERK pathways. Vivar, Raúl; Humeres, Claudio; Varela, Marcelo; Ayala, Pedro; Guzmán, Nancy; Olmedo, Ivonne; Catalán, Mabel; Boza, Pía; Muñoz, Claudia; Díaz Araya, Guillermo Article Experimental and molecular pathology (2012)
Differential regulation of collagen secretion by kinin receptors in cardiac fibroblast and myofibroblast. Catalán, Mabel; Smolic, Christian; Contreras, Ariel; Ayala, Pedro; Olmedo, Ivonne; Copaja, Miguel; Boza, Pía; Vivar, Raúl; Avalos, Yennifer; Lavandero, Sergio; Velarde, Victoria; Díaz-Araya, Guillermo Article Toxicology and applied pharmacology (2012)
Differential Participation of Angiotensin II Type 1 and 2 Receptors in the Regulation of Cardiac Cell Death Triggered by Angiotensin II Aranguiz-Urroz, P; Soto D.; Contreras A.; Troncoso R.; Chiong M.; Montenegro J.; Venegas, D.; Smolic, C; Ayala P.; Thomas, WG; Lavandero S.; Diaz-Araya, G Article AMERICAN JOURNAL OF HYPERTENSION (2009)


Computational Micromechanics of the Lung Parenchyma FONDECYT (1180832) Proyecto 2018-2021 Coinvestigador(a)
MYOFIBROBLAST IN THE LUNG AFTER INSTILLATION OF WHOLE GASTRIC JUICE IN A RAT MODEL=> A NORMAL REPARATIVE PROCESS OR A STARTING POINT FOR THE DEVELOPMENT OF CHRONIC FIBROSIS? FONDECYT (11140913) Proyecto 2014-2017 Inv. Responsable
ROLE OF TLR4 AND INFLAMMASOME IN THE DIFFERENTIATION AND ACQUISITION OF A PROINFLAMMATORY PHENOTYPE OF ADULT RAT CARDIAC MYOFIBROBLAST FONDECYT (1130300) Proyecto 2013-2017 Personal técnico y/o de apoyo
SYSTEMIC INFLAMMATORY RESPONSE ELICITED BY BLEOMYCIN-INDUCED ACUTE LUNG INJURY AND GASTRIC FLUID-INDUCED ACUTE LUNG INJURY=> DO SPECIES DIFFERENCES IN ANTIPROTEASE LIVER SYNTHESIS INFLUENCE LUNG ANTIPROTEASE PROTECTION AND SEVERITY OF CHRONIC DAMAGE? FONDECYT (1120943) Proyecto 2012-2015 Personal técnico y/o de apoyo
KININ AND BETA2-ADRENERGIC RECEPTORS IN CARDIAC MYOFIBROBLASTS AND THEIR RELATIONSHIPS WITH CARDIAC FIBROSIS FONDECYT (1100443) Proyecto 2010-2013 Tesista
ANGIOTENSINA II Y SUS RECEPTORES SUBTIPOS AT1 Y AT2 EN LA REGULACION DE LA FUNCION Y SOBREVIDA DEL FIBROBLASTO Y MIOFIBROBLASTO CARDIACO. FONDECYT (1061059) Proyecto 2006-2009 Tesista