Foto_cv.jpg_thumb90

Pedro Segundo Ayala Jeria

Profesor investigador asistente

Pontificia Universidad Católica de Chile

Santiago, Chile

Líneas de Investigación


Mecanismos fisiopatológicos de la reparación y fibrosis pulmonar después de daño inducido por aspiración de contenido digestivo en ratas. Daño pulmonar agudo Modelamiento de la micro mecánica pulmonar en ratas.

Educación

  •  Farmacologia, UNIVERSIDAD DE CHILE. Chile, 2013
  •  Químico Farmacéutico, UNIVERSIDAD DE CHILE. Chile, 2009
  •  Docencia Universitaria, PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE. Chile, 2020
  •  Gestión de estudios clínicos, PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE. Chile, 2021

Experiencia Académica

  •   Profesor Investigador Asistente Full Time

    PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

    Facultad de Medicina

    Santiago, Chile

    2018 - A la fecha

  •   Profesor asociado Part Time

    Universidad Pedro de Valdivia

    Facultad de ciencias de la salud

    Chile

    2013 - 2013

  •   Apouo a la Investigacion Full Time

    PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

    Facultad de Medicina

    Chile

    2013 - 2018


 

Article (20)

Toll-Like Receptor 4 Activation Prevents Rat Cardiac Fibroblast Death Induced by Simulated Ischemia/Reperfusion
Near-Apneic Ventilation Decreases Lung Injury and Fibroproliferation in an Acute Respiratory Distress Syndrome Model with Extracorporeal Membrane Oxygenation
TGF-beta 1 induced up-regulation of B1 kinin receptor promotes antifibrotic activity in rat cardiac myofibroblasts
Acute lung injury by gastric fluid instillation=> activation of myofibroblast apoptosis during injury resolution.
Changes in the pattern of fibrosis in the rat lung with repetitive orotracheal instillations of gastric contents=> Evidence of persistent collagen accumulation.
Elastin degradation products in acute lung injury induced by gastric contents aspiration
Lipopolysaccharide Activates Toll-Like Receptor 4 and Prevents Cardiac Fibroblast-to-Myofibroblast Differentiation.
Acute lung injury induced by whole gastric fluid: hepatic acute phase response contributes to increase lung antiprotease protection.
Expression and function of toll-like receptor 4 and inflammasomes in cardiac fibroblasts and myofibroblasts: IL-1β synthesis, secretion, and degradation.
Resolution of lung injury after a single event of aspiration: a model of bilateral instillation of whole gastric fluid.
4-Phenylbutyric acid prevent cytotoxicity induced by thapsigargin in rat cardiac fibroblast
4-Phenylbutyric acid prevent cytotoxicity induced by thapsigargin in rat cardiac fibroblast.
A novel dihydropyridine with 3-aryl meta-hydroxyl substitution blocks L-type calcium channels in rat cardiomyocytes.
Angiotensin-(1-9) reverses experimental hypertension and cardiovascular damage by inhibition of the angiotensin converting enzyme/Ang II axis
EPAC expression and function in cardiac fibroblasts and myofibroblasts
TGF-beta 1 prevents simulated ischemia/reperfusion-induced cardiac fibroblast apoptosis by activation of both canonical and non-canonical signaling pathways
Attenuation of endoplasmic reticulum stress using the chemical chaperone 4-phenylbutyric acid prevents cardiac fibrosis induced by isoproterenol.
Cardiac fibroblast death by ischemia/reperfusion is partially inhibited by IGF-1 through both PI3K/Akt and MEK-ERK pathways.
Differential regulation of collagen secretion by kinin receptors in cardiac fibroblast and myofibroblast.
Differential Participation of Angiotensin II Type 1 and 2 Receptors in the Regulation of Cardiac Cell Death Triggered by Angiotensin II

Proyecto (6)

Computational Micromechanics of the Lung Parenchyma
MYOFIBROBLAST IN THE LUNG AFTER INSTILLATION OF WHOLE GASTRIC JUICE IN A RAT MODEL=> A NORMAL REPARATIVE PROCESS OR A STARTING POINT FOR THE DEVELOPMENT OF CHRONIC FIBROSIS?
ROLE OF TLR4 AND INFLAMMASOME IN THE DIFFERENTIATION AND ACQUISITION OF A PROINFLAMMATORY PHENOTYPE OF ADULT RAT CARDIAC MYOFIBROBLAST
SYSTEMIC INFLAMMATORY RESPONSE ELICITED BY BLEOMYCIN-INDUCED ACUTE LUNG INJURY AND GASTRIC FLUID-INDUCED ACUTE LUNG INJURY=> DO SPECIES DIFFERENCES IN ANTIPROTEASE LIVER SYNTHESIS INFLUENCE LUNG ANTIPROTEASE PROTECTION AND SEVERITY OF CHRONIC DAMAGE?
KININ AND BETA2-ADRENERGIC RECEPTORS IN CARDIAC MYOFIBROBLASTS AND THEIR RELATIONSHIPS WITH CARDIAC FIBROSIS
ANGIOTENSINA II Y SUS RECEPTORES SUBTIPOS AT1 Y AT2 EN LA REGULACION DE LA FUNCION Y SOBREVIDA DEL FIBROBLASTO Y MIOFIBROBLASTO CARDIACO.
4
Pedro Ayala

Profesor investigador asistente

Departamento de Enfermedades Respiratorias

Pontificia Universidad Católica de Chile

Santiago, Chile

1
Jaime Retamal

Profesor Asistente

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

Santiago, Chile

1
Sergio Lavandero

Director

Advanced Center for Chronic Diseases (ACCDiS)

UNIVERSIDAD DE CHILE, FAC CIENCIAS QUÍMICAS Y FARMACÉUTICAS

Santiago, Chile

1
Tania Medina

Enfermera clínica

Hospital El Carmen

Santiago, Chile

1
Rodrigo Cornejo

Jefe de Servicio

Medicina

UNIVERSAIDAD DE CHILE-HOSPITAL CLINICO UNIVERSIDAD DE CHILE

Santiago, Chile

1
Raúl Vivar

Profesor Asistente

Universidad de Chile

Santiago, Chile

1
Pablo Cruces

MEDICO RESIDENTE

PEDIATRIA

HOSPITAL EL CARMEN DE MAIPU

SANTIAGO, Chile

1
daniel hevia

Investigador PhD

Inmunologia

Universidad de Chile

santiago, Chile

1
Maria Ocaranza

Asociate Professor

Cardiovascular Diseases Division

Pontificia Universidad Catolica de Chile

Santiago, Chile

1
Luis Michea

PROFESOR ASOCIADO

PROGRAMA FISIOLOGIA Y BIOFISICA

UNIVERSIDAD DE CHILE

Santiago, Chile

1
Rodrigo Alzamora

ASSISTANT PROFESSOR

INSTITUTE OF BIOMEDICAL SCIENCES

UNIVERSIDAD DE CHILE

Santiago, Chile

1
Mario Chiong

Profesor

Departamento de Bioquímica y Biología Molecular

Universidad de Chile

Santiago, Chile