Farmacología molecular cardiovascular; fibrosis cardiaca; patologias cardiovasculares; Inflamación; Estrés oxidativo

PhD thesis finished

1. Claudio Humeres Martínez: "Differential role of TLR4 on the adhesion and activation of m1 / m2 macrophages in fibroblasts and cardiac myofibroblasts". Doctorate Thesis in Pharmacology. Faculty of Chemical and Pharmaceutical Sciences, University of Chile. Completion date November 2016.

2. Pía Boza Fuentes: "New role of Angiotensin II: activates the inflammasome in fibroblasts and cardiac myofibroblasts". Doctorate Thesis in Pharmacology. Faculty of Chemical and Pharmaceutical Sciences, University of Chile. Completion date November 2016.

3. Samir Bolivar González. Interferon Beta decreases the expression of pro-inflammatory cytokines and the fibrotic response in the cardiac fibroblast of adult rats. Doctoral Thesis in Pharmaceutical Sciences. Faculty of Chemical and Pharmaceutical Sciences, University of Chile. Start date ended July 2018.

4. Glauben Landskron: "Role of extracellular ATP in the release of IL33 by cancer-associated fibroblasts and the effect of this cytokine on the epithelial-mesenchymal transition of a colorectal adenocarcinoma cell line", PhD Thesis in Biomedical Sciences. Faculty of Medicine, University of Chile. Completation date December 2018.

5. Claudia Muñoz Rodríguez: "Effect of LPS on the expression of receptors B1 and B2 of kinins in fibroblasts and cardiac myofibroblasts". Doctoral Thesis in Pharmaceutical Sciences. Faculty of Chemical and Pharmaceutical Sciences, University of Chile. ECompletatio date January 2019.

6. Viviana Pardo Jiménez: "Synthesis of new coumarin derivatives and evaluation of their inhibitory activity of histone deacetylase in cardiac fibroblasts". Doctoral Thesis in Pharmaceutical Sciences. Faculty of Chemical and Pharmaceutical Sciences, University of Chile. May 2019.

PhD Thesis in course

7. Pablo Parra: "Optimization of the treatment with Vitamin C, N-acetyl cysteine ??and Desferoxamine in the prevention of death by ischemia reperfusion in an in vivo and in vitro model in cardiac fibroblasts of adult rats. Doctorate Thesis in Pharmacology. Faculty of Chemical and Pharmaceutical Sciences, University of Chile. Start date September 2016.

8. Paula Valenzuela: Evaluación comparativa de la actividad cicatrizante cutánea de extractos concentrados en fenoles y en triterpenoides obtenidos de hojas de distintos genotipos de Ugni molinae Turcz. Doctorate Thesis in Pharmaceutical Sciences. Faculty of Chemical and Pharmaceutical Sciences, University of Chile. Start date September 2016.

9. Aimée Salas: Effect of Resolvin D1 on the proinflammatory effect triggered by Ang II in cardiac fibroblasts. Doctorate Thesis in Pharmacology. Faculty of Chemical and Pharmaceutical Sciences, University of Chile. Start date September 2017.

10. Francisco Olivares Silva: Resolvina D1 previene la hipertensión cardiaca inducida por Ang II. Doctorate Thesis in Pharmacology. Faculty of Chemical and Pharmaceutical Sciences, University of Chile. Start date April 2018.

12. Ileana Carrillo. Resolvina D1 gatillada por aspirina (AT-RvD1) limita el progreso de la Cardiomiopatía Chagásica Crónica, disminuyendo la expresión de TNF? y la apoptosis de células musculares cardíacas. Doctorate Thesis in Pharmacology. Faculty of Chemical and Pharmaceutical Sciences, University of Chile. Start date June 2019.

Undergraduate Thesis

Finished
2019
- Resolvina-D1 a través del receptor ALX/FPR2 aumenta la síntesis de colágeno en miofibroblastos cardiacos de rata adulta. Memory to obtain the title of Chemist-Pharmacist by Esteban Castro Carrasco. Faculty of Chemical and Pharmaceutical Sciences, University of Chile.

- Efecto de Angiotensina II sobre los niveles de mRNA de citoquinas y moléculas de adhesión en fibroblastos cardiacos. Memory to obtain the title of Chemist-Pharmacist by Francisca Bruggendieck. Faculty of Chemical and Pharmaceutical Sciences, University of Chile.

2018
- La Resolvina D1 previene el aumento de ICAM y VCAM inducido por heparan sulfato en fibroblastos cardiacos. Memory to obtain the title of Chemist-Pharmacist by Víctor Aaron Velarde Lipín. Faculty of Chemical and Pharmaceutical Sciences, University of Chile.

-Vías de señalización intracelulares activadas por Resolvina D1 y E1 en fibroblastos cardiacos. Memory to obtain the title of Chemist-Pharmacist by Jossete Cayupi Vivanco. Faculty of Chemical and Pharmaceutical Sciences, University of Chile.

- Resolvina E1 previene el aumento de ICAM-1 inducido por Ang II en fibroblastos cardiacos. Memory to obtain the title of Chemist-Pharmacist by Felipe Ruz Cortés. Faculty of Chemical and Pharmaceutical Sciences, University of Chile.

 2017
• Effect of Resolvin D1 on the viability and expression of ICAM-1 in cardiac fibroblasts. Memory to obtain the title of Chemist-Pharmacist by Ninoska Ramírez. Faculty of Chemical and Pharmaceutical Sciences, University of Chile.

• Effect of Resolvin E1 on the expression of VCAM-1 in cardiac fibroblasts. Memory to obtain the title of Chemist-Pharmacist by Natalia Muñoz. Faculty of Chemical and Pharmaceutical Sciences, University of Chile.

• Transduction pathways activated by RvD1 and cardiac fibroblasts. Memory to obtain the title of Chemist-Pharmacist by Pablo Sepúlveda. Faculty of Chemical and Pharmaceutical Sciences, University of Chile.

2016
• Effect of Heparan sulfate on the expression of cytokines and chemokines in cardiac fibroblasts: effects on monocyte chemoattraction. Report to obtain the title of Chemist-Pharmacist by Francisco Olivares Silva. Faculty of Chemical and Pharmaceutical Sciences, University of Chile.

• Expression of E-selectin in cardiac fibroblasts: effects on neutrophil binding and activity of MMPs, and change in phenotype to myofibroblast. Memory to obtain the title of Chemist-Pharmacist by José Miguel Osorio. Faculty of Chemical and Pharmaceutical Sciences, University of Chile.

• Expression of IL-8 in cardiac fibroblasts: effects on the chemoattraction of neutrophils. Renatto Anfossi. Report to obtain the degree of Chemist-Pharmacist by Faculty of Chemical and Pharmaceutical Sciences, University of Chile.

• Expression of VCAM, ICAM by Bradykinins in cardiac fibroblasts: effects on the adhesion of neutrophils. Report to obtain the title of Chemist-Pharmacist by Samuel Fernández Sandoval. Faculty of Chemical and Pharmaceutical Sciences, University of Chile.
    
2015
• Transduction pathways activated by TLR4 that control the expression of VCAM and ICAM. Memory to obtain the title of Chemist-Pharmacist by Elias Inostroza. Faculty of Chemical and Pharmaceutical Sciences, University of Chile.

• Comparative study of the expression and activity of the NLRP3 inflammasome in fibroblasts and cardiac myofibroblasts. Memory to obtain the title of Chemist-Pharmacist by Felipe Tapia. Faculty of Chemical and Pharmaceutical Sciences, University of Chile

• Heparan Sulfate, through TLR4, triggers both the increase in IL-1?, ICAM and VCAM, and the decrease in ?-SMA. Memory to obtain the title of Chemist-Pharmacist by Rodolfo Landaeta. Faculty of Chemical and Pharmaceutical Sciences, University of Chile.

• Participation of TLR4 receptors in the protection against cardiac fibroblast death induced by hypoxia / reoxygenation. Memory to obtain the title of Chemist-Pharmacist by Cristian Queirolo. Faculty of Chemical and Pharmaceutical Sciences, University of Chile.

• Participation of TLR4 in the differentiation of fibroblast to myofibroblast. Memory to obtain the title of Chemist-Pharmacist by Roxana Santana. Faculty of Chemical and Pharmaceutical Sciences, University of Chile.