
Guillermo Antonio Díaz Araya
Académico
UNIVERSIDAD DE CHILE, FACULTAD DE CIENCIAS QUÍMICAS Y FARMACÉUTICAS
Santiago, Chile
Farmacología molecular cardiovascular; fibrosis cardiaca; patologias cardiovasculares; Inflamación; Estrés oxidativo
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Ciencias Biológicas, Universidad Autónoma de Madrid. España, 1992
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Académico Full Time
UNIVERSIDAD DE CHILE
Ciencias Químicas y Farmacéuticas
Santiago de Chile, Chile
1993 - A la fecha
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Académico Full Time
Universidad de Chile
Santiago, Chile
1994 - A la fecha
PhD thesis finished
1. Claudio Humeres Martínez: "Differential role of TLR4 on the adhesion and activation of m1 / m2 macrophages in fibroblasts and cardiac myofibroblasts". Doctorate Thesis in Pharmacology. Faculty of Chemical and Pharmaceutical Sciences, University of Chile. Completion date November 2016.
2. Pía Boza Fuentes: "New role of Angiotensin II: activates the inflammasome in fibroblasts and cardiac myofibroblasts". Doctorate Thesis in Pharmacology. Faculty of Chemical and Pharmaceutical Sciences, University of Chile. Completion date November 2016.
3. Samir Bolivar González. Interferon Beta decreases the expression of pro-inflammatory cytokines and the fibrotic response in the cardiac fibroblast of adult rats. Doctoral Thesis in Pharmaceutical Sciences. Faculty of Chemical and Pharmaceutical Sciences, University of Chile. Start date ended July 2018.
4. Glauben Landskron: "Role of extracellular ATP in the release of IL33 by cancer-associated fibroblasts and the effect of this cytokine on the epithelial-mesenchymal transition of a colorectal adenocarcinoma cell line", PhD Thesis in Biomedical Sciences. Faculty of Medicine, University of Chile. Completation date December 2018.
5. Claudia Muñoz Rodríguez: "Effect of LPS on the expression of receptors B1 and B2 of kinins in fibroblasts and cardiac myofibroblasts". Doctoral Thesis in Pharmaceutical Sciences. Faculty of Chemical and Pharmaceutical Sciences, University of Chile. ECompletatio date January 2019.
6. Viviana Pardo Jiménez: "Synthesis of new coumarin derivatives and evaluation of their inhibitory activity of histone deacetylase in cardiac fibroblasts". Doctoral Thesis in Pharmaceutical Sciences. Faculty of Chemical and Pharmaceutical Sciences, University of Chile. May 2019.
PhD Thesis in course
7. Pablo Parra: "Optimization of the treatment with Vitamin C, N-acetyl cysteine ??and Desferoxamine in the prevention of death by ischemia reperfusion in an in vivo and in vitro model in cardiac fibroblasts of adult rats. Doctorate Thesis in Pharmacology. Faculty of Chemical and Pharmaceutical Sciences, University of Chile. Start date September 2016.
8. Paula Valenzuela: Evaluación comparativa de la actividad cicatrizante cutánea de extractos concentrados en fenoles y en triterpenoides obtenidos de hojas de distintos genotipos de Ugni molinae Turcz. Doctorate Thesis in Pharmaceutical Sciences. Faculty of Chemical and Pharmaceutical Sciences, University of Chile. Start date September 2016.
9. Aimée Salas: Effect of Resolvin D1 on the proinflammatory effect triggered by Ang II in cardiac fibroblasts. Doctorate Thesis in Pharmacology. Faculty of Chemical and Pharmaceutical Sciences, University of Chile. Start date September 2017.
10. Francisco Olivares Silva: Resolvina D1 previene la hipertensión cardiaca inducida por Ang II. Doctorate Thesis in Pharmacology. Faculty of Chemical and Pharmaceutical Sciences, University of Chile. Start date April 2018.
12. Ileana Carrillo. Resolvina D1 gatillada por aspirina (AT-RvD1) limita el progreso de la Cardiomiopatía Chagásica Crónica, disminuyendo la expresión de TNF? y la apoptosis de células musculares cardíacas. Doctorate Thesis in Pharmacology. Faculty of Chemical and Pharmaceutical Sciences, University of Chile. Start date June 2019.
Undergraduate Thesis
Finished
2019
- Resolvina-D1 a través del receptor ALX/FPR2 aumenta la síntesis de colágeno en miofibroblastos cardiacos de rata adulta. Memory to obtain the title of Chemist-Pharmacist by Esteban Castro Carrasco. Faculty of Chemical and Pharmaceutical Sciences, University of Chile.
- Efecto de Angiotensina II sobre los niveles de mRNA de citoquinas y moléculas de adhesión en fibroblastos cardiacos. Memory to obtain the title of Chemist-Pharmacist by Francisca Bruggendieck. Faculty of Chemical and Pharmaceutical Sciences, University of Chile.
2018
- La Resolvina D1 previene el aumento de ICAM y VCAM inducido por heparan sulfato en fibroblastos cardiacos. Memory to obtain the title of Chemist-Pharmacist by Víctor Aaron Velarde Lipín. Faculty of Chemical and Pharmaceutical Sciences, University of Chile.
-Vías de señalización intracelulares activadas por Resolvina D1 y E1 en fibroblastos cardiacos. Memory to obtain the title of Chemist-Pharmacist by Jossete Cayupi Vivanco. Faculty of Chemical and Pharmaceutical Sciences, University of Chile.
- Resolvina E1 previene el aumento de ICAM-1 inducido por Ang II en fibroblastos cardiacos. Memory to obtain the title of Chemist-Pharmacist by Felipe Ruz Cortés. Faculty of Chemical and Pharmaceutical Sciences, University of Chile.
2017
• Effect of Resolvin D1 on the viability and expression of ICAM-1 in cardiac fibroblasts. Memory to obtain the title of Chemist-Pharmacist by Ninoska Ramírez. Faculty of Chemical and Pharmaceutical Sciences, University of Chile.
• Effect of Resolvin E1 on the expression of VCAM-1 in cardiac fibroblasts. Memory to obtain the title of Chemist-Pharmacist by Natalia Muñoz. Faculty of Chemical and Pharmaceutical Sciences, University of Chile.
• Transduction pathways activated by RvD1 and cardiac fibroblasts. Memory to obtain the title of Chemist-Pharmacist by Pablo Sepúlveda. Faculty of Chemical and Pharmaceutical Sciences, University of Chile.
2016
• Effect of Heparan sulfate on the expression of cytokines and chemokines in cardiac fibroblasts: effects on monocyte chemoattraction. Report to obtain the title of Chemist-Pharmacist by Francisco Olivares Silva. Faculty of Chemical and Pharmaceutical Sciences, University of Chile.
• Expression of E-selectin in cardiac fibroblasts: effects on neutrophil binding and activity of MMPs, and change in phenotype to myofibroblast. Memory to obtain the title of Chemist-Pharmacist by José Miguel Osorio. Faculty of Chemical and Pharmaceutical Sciences, University of Chile.
• Expression of IL-8 in cardiac fibroblasts: effects on the chemoattraction of neutrophils. Renatto Anfossi. Report to obtain the degree of Chemist-Pharmacist by Faculty of Chemical and Pharmaceutical Sciences, University of Chile.
• Expression of VCAM, ICAM by Bradykinins in cardiac fibroblasts: effects on the adhesion of neutrophils. Report to obtain the title of Chemist-Pharmacist by Samuel Fernández Sandoval. Faculty of Chemical and Pharmaceutical Sciences, University of Chile.
2015
• Transduction pathways activated by TLR4 that control the expression of VCAM and ICAM. Memory to obtain the title of Chemist-Pharmacist by Elias Inostroza. Faculty of Chemical and Pharmaceutical Sciences, University of Chile.
• Comparative study of the expression and activity of the NLRP3 inflammasome in fibroblasts and cardiac myofibroblasts. Memory to obtain the title of Chemist-Pharmacist by Felipe Tapia. Faculty of Chemical and Pharmaceutical Sciences, University of Chile
• Heparan Sulfate, through TLR4, triggers both the increase in IL-1?, ICAM and VCAM, and the decrease in ?-SMA. Memory to obtain the title of Chemist-Pharmacist by Rodolfo Landaeta. Faculty of Chemical and Pharmaceutical Sciences, University of Chile.
• Participation of TLR4 receptors in the protection against cardiac fibroblast death induced by hypoxia / reoxygenation. Memory to obtain the title of Chemist-Pharmacist by Cristian Queirolo. Faculty of Chemical and Pharmaceutical Sciences, University of Chile.
• Participation of TLR4 in the differentiation of fibroblast to myofibroblast. Memory to obtain the title of Chemist-Pharmacist by Roxana Santana. Faculty of Chemical and Pharmaceutical Sciences, University of Chile.
Proinflammaroty mechanisms in cardiovascular diseases: targets for pharmacological interference" |
Resolvin D1 and E1 novel pharmacological targets for preventing hypertension-dependent cardiac fibrosis: a focus on the proinflammatory role of cardiac fibroblasts |
Effect of Exercise Training in Inflammation, Oxidative Stress, Pro-fibrotic miRNA Levels and Left Ventricular Response to Exertion in Patients with Heart Failure with Preserved Ejection Fraction Hugo Verdejo / Guillermo Díaz Araya |
Centro Avanzado para las enfermedades crónicas ACCDiS |
OX-LDL/LOX-1/NADPH OXIDASE SIGNALING PATHWAY IN CARDIAC MYOFIBROBLAST=> NOVEL ROLE IN THE REGULATION OF AUTOPHAGY,SURVIVAL AND PROFIBROTIC RESPONSE |
Neuroendocrine regulation of the rat ovary: Prenatal exposure to sympathetic stress and its transgenerational effects on the reproductive function of the progeny |
ROLE OF TLR4 AND INFLAMMASOME IN THE DIFFERENTIATION AND ACQUISITION OF A PROINFLAMMATORY PHENOTYPE OF ADULT RAT CARDIAC MYOFIBROBLAST |
KININ AND BETA2-ADRENERGIC RECEPTORS IN CARDIAC MYOFIBROBLASTS AND THEIR RELATIONSHIPS WITH CARDIAC FIBROSIS |
Neonatal exposure to estradiol and stress in rats activates neural genes and programs sympathetic nerve activity to determine changes in reproductive function and polycystic ovary development. |
RESISTENCIA A INSULINA EN LA DIABETES TIPO II=> ESTUDIO DE NUEVOS MECANISMOS FISIOPATOLOGICOS ASOCIADOS AL DETERIORO DE LA FUNCION CARDIACA |
ANGIOTENSINA II Y SUS RECEPTORES SUBTIPOS AT1 Y AT2 EN LA REGULACION DE LA FUNCION Y SOBREVIDA DEL FIBROBLASTO Y MIOFIBROBLASTO CARDIACO. |
ESTRES OXIDATIVO, INFLAMACION Y DISFUNCION ENDOTELIAL EN LA INSUFICIENCIA CARDIACA CRONICA=>EFECTOS DE LA INHIBICION DE LA XANTINO-OXIDASA Y 3-HIDROXI-3-METILGLUTARIL-CoA REDUCTASA. |
ENZIMA CONVERTIDORA DE ANGIOTENSINA I HOMOLOGA (ECA-2) EN LA DISFUNCION VENTRICULAR IZQUIERDA EXPERIMENTAL |
Centro de estudios moleculares de la célula FONDAP CEMC |
FIBROSIS MIOCARDICA INDUCIDA POR CATECOLAMINAS=> INFLUENCIA DE LAS VARIANTES ALELICAS DEL GEN DE LA ENZIMA CONVERTIDORA DE ANGIOTENSINA-I (ECA) EN SU DESARROLLO. |
MECANISMOS DE TRANSDUCCION DE SENALES DEL IGF-1=>REGULACION DIFERENCIAL DE FACTORES TRANSCRIPCIONALES ASOCIADOS A LOS PROCESOS DE HIPERTROFIA Y APOPTOSIS DEL CARDIOMIOCITO |
DISOCIACION DE LAS DIFERENTES VIAS TRANSDUCCIONALES DEL FACTOR DE CRECIMIENTO ANALOGO A INSULINA TIPO-1 (IGF-1) EN LOS PROCESOS DE HIPERTROFIA X APOPTOSIS DEL CARBIOMIOCITO |
PARTICIPACION DEL IGF-I EN LA GENESIS Y DESARROLLO DE LA HIPERTROFIA CARDIACA PATOLOGICA EXPERIMENTAL=> ESTUDIO Y MODULACION FARMACOLOGICA DE SUS MECANISMOS DE TRANSDUCCION |
Silencing or not silencing p63 in cardiac fibroblast, risks and benefits |

Guillermo Díaz
Académico
Química Farmacológica y Toxicológica
UNIVERSIDAD DE CHILE, FACULTAD DE CIENCIAS QUÍMICAS Y FARMACÉUTICAS
Santiago, Chile

Sergio Lavandero
Director
Advanced Center for Chronic Diseases (ACCDiS)
UNIVERSIDAD DE CHILE, FAC CIENCIAS QUÍMICAS Y FARMACÉUTICAS
Santiago, Chile

Francisco Olivares
Pharmacology PhD(c)
Department of Pharmaceutical and Toxicological Chemistry
Universidad de Chile
Santiago, Chile

Viviana Pardo
Profesional docente
Química Farmacológica y Toxicológica
Universidad de Chile
Santiago, Chile

Santiago Sepúlveda
Profesional Tecnólogo Médico
Anatomía Patológica
Pontificia Universidad Católica de Chile
Santiago, Chile

IVAN GALLEGOS
PATHOLOGIST, LABORATORY DIRECTOR
PATHOLOGY
HOSPITAL CLINICO DE UNIVERSIDAD DE CHILE
SANTIAGO, Chile

Alfredo Criollo
Assistant professor
Research Institute in Dental Sciences
Facultad de Odontología, Universidad de Chile
Santiago, Chile

Hector Contreras
Academico
Oncologia Basico Clinica
UNIVERSIDAD DE CHILE, FACULTAD DE MEDICINA, INSTITUTO DE CIENCIAS BIOMÉDICAS, PROGRAMA DE FISIOLOGÍA Y BIOFÍSICA
Santiago, Chile

Daniela Parada
Asistente de investigación
Programa Disciplinario de Inmunología
Universidad de Chile
Santiago, Chile

Mario Chiong
Profesor
Departamento de Bioquímica y Biología Molecular
Universidad de Chile
Santiago, Chile

Maria Ocaranza
Asociate Professor
Cardiovascular Diseases Division
Pontificia Universidad Catolica de Chile
Santiago, Chile

Carolina Nazzal
Profesor Asociado
Instituto de Salud Poblacional
Universidad de Chile
Santiago, Chile

Zully Pedrozo
Assistant professor
Physiology and Biophysical
Universidad de Chile
SANTIAGO DE CHILE, Chile