Man

Gonzalo Yévenes

Associate Professor

Universidad de Concepcion

Concepcion, Chile

Líneas de Investigación


Neuropharmacology - Cell biology - Molecular Biology - Signal transduction

Educación

  •  Biochemist, Universidad de Concepcion. Chile, 2002
  •  Neuroscience/Molecular Biology, Universidad de Concepcion. Chile, 2007
  •  Doctor en ciencias biológicas, UNIVERSIDAD DE CONCEPCION. Chile, 2007

Experiencia Académica

  •   Assistant Professor Full Time

    UNIVERSIDAD DE CONCEPCION

    Faculty of Biological Sciences

    Concepcion, Chile

    2013 - 2018

  •   Postdoctoral Fellow Full Time

    UNIVERSITY OF ZURICH

    Zurich, Suiza

    2008 - 2013

  •   Associate Professor Full Time

    UNIVERSIDAD DE CONCEPCION

    Faculty of Biological Sciences

    Chile

    2019 - A la fecha

Experiencia Profesional

  •   Associate professor Full Time

    Universidad de Concepcion

    Concepcion, Chile

    2018 - A la fecha

Formación de Capital Humano


1. Participation in regular undergraduate courses of General Physiology (Univ. of Concepcion): Medicine, Nutrition, Dentistry, Pharmacy, Bioengineering, Biomedical Engineering, Biochemistry, Nursery, Psychology, Kinesiology, among others.
2. Participation in regular postgraduate courses (Univ. of Concepcion): Master in Neurobiology Program (Advanced Neuroscience),Master Program on Human physiology (Advanced Physiology I and II), PhD program on Cell and molecular biology (Cell biology).
3. Head of the Master of Neurobiology Program (Univ. of Concepcion)
4. Human resources formation as thesis supervisor:
4.1 Undergraduate thesis projects: 4 completed,
4.2 Master thesis projects: 6 completed, 2 ongoing
4.3 PhD thesis projects: 3 ongoing


Difusión y Transferencia


1. Participation on the National Program “1000 Scientists,1000 Classrooms” of the National Week of Science and Technology
• How we feel pain? Jorge Alessandri Rodríguez C-88 School, San Fabián de Alico, Provincia de Ñuble, VIII región. 2014
• How we feel pain? Teresa de los Andes School, Bulnes, Provincia de Ñuble, VIII región. 2014
• Marihuana within our body? Monseñor Alfredo Silva Santiago Special School, Concepción, VIII región. 2014
• Marihuana within our body? Municipal Schhol of Nacimiento, Provincia de Ñuble, VIII región. 2015
• Marihuana within our body? Aurora de Chile Sur School, Chiguayante, VIII región. 2015
• Marihuana within our body? Liceo Industrial de Concepción, VIII región. 11 de Octubre 2017
• Marihuana within our body? Liceo El Arrayan, San Pedro de la Paz, VIII región. 17 de Octubre 2017
• How we feel pain?Colegio Santa Bernardita, Talcahuano, VIII Región, 19 de Octubre de 2017
2. Radio Interview on “Voices of Science” program, in Universidad de Concepción Radio. 2015.
3. Interview in "El Mercurio" newspaper. Article “New testings of novel analgesics for chronic pain”. August 2, 2016. Link: http://impresa.elmercurio.com/Pages/NewsDetail.aspx?dt=2016-08-02&dtB=02-08-2016%200:00:00&PaginaId=10&bodyid=1
4. Interview in "Concepción Newspaper". Artícle “Pharmacology testing to improve the quality of life”August 16, 2016. Link: http://www.diarioconcepcion.cl/2016/08/21/#13/z
5. “Brain Awareness week” March 2018, 2019. talk: How we feel pain? Activity organized by DANA foundation and SFN. Concepcion, Chile.


Premios y Distinciones

  •   Best Undergraduate Thesis

    Foundation of Cell Biology and the Chilean Society for Cell Biology

    Chile, 2002

    Awarded the Best Undergraduate and Master Thesis performed in Chile by the Foundation of Cell Biology and the Chilean Society for Cell Biology, 2002.

  •   Best PhD Thesis

    Foundation of Cell Biology and the Chilean Society for Cell Biology

    Chile, 2007

    Awarded the Best Doctoral Thesis of the year by the Foundation of Cell Biology and the Chilean Society for Cell Biology, 2007.

  •   “Chile Bicentennial Award”

    Chilean Ministry of Education and Bicentennial Committee

    Chile, 2007

    Awarded the “Chile Bicentennial Award” as the Best Chilean PhD thesis of the year (on all the fields of Basic Science) by the Chilean Ministry of Education and Bicentennial Committee, 2007.

  •   Best Poster Presentation

    UNIVERSITY OF ZURICH

    Suiza, 2011

    Awarded the Best poster in the “Zurich Pharmacology & Toxicology Day " by the University of Zurich, 2011

  •   Elly Lilly Chapter Travel Award

    Society of Neuroscience

    Estados Unidos, 2005

    Support for Assistance to SFN 2005, given by the Society for Neuroscience, USA.


 

Article (44)

Altered Glutaminase 1 Activity During Neurulation and Its Potential Implications in Neural Tube Defects
Changes in PGC-1 alpha/SIRT1 Signaling Impact on Mitochondrial Homeostasis in Amyloid-Beta Peptide Toxicity Model
Editorial: Celebrating 40 Years of the Chilean Society of Pharmacology
Inhibition of the Glycine Receptor alpha 3 Function by Colchicine
Modulation of glycine receptor single-channel conductance by intracellular phosphorylation
Modulation of glycine receptor single-channel conductance by intracellular phosphorylation.
Stereospecific Inhibition of Ethanol Potentiation on Glycine Receptor by M554 Stereoisomers
17 Oxo Sparteine and Lupanine, Obtained from Cytisus scoparius, Exert a Neuroprotection against Soluble Oligomers of Amyloid-beta Toxicity by Nicotinic Acetylcholine Receptors
Inhibitory Actions of Tropeines on the alpha 3 Glycine Receptor Function
Inhibitory Actions of Tropeines on the alpha3 Glycine Receptor Function.
Large Intracellular Domain-Dependent Effects of Positive Allosteric Modulators on Glycine Receptors
Cytotoxicity and in vivo plasma kinetic behavior of surface-functionalized PAMAM dendrimers
P2X receptor overexpression induced by soluble oligomers of amyloid beta peptide potentiates synaptic failure and neuronal dyshomeostasis in cellular models of Alzheimer's disease
Presence of Inhibitory Glycinergic Transmission in Medium Spiny Neurons in the Nucleus Accumbens
Prevention of Synaptic Alterations and Neurotoxic Effects of PAMAM Dendrimers by Surface Functionalization
Functional modulation of glycine receptors by the alkaloid gelsemine
Functional modulation of glycine receptors by the alkaloid gelsemine.
Phosphorylation state-dependent modulation of spinal glycine receptors alleviates inflammatory pain.
Phosphorylation state?dependent modulation of spinal glycine receptors alleviates inflammatory pain
Reversal of Ethanol-induced Intoxication by a Novel Modulator of G?? Protein Potentiation of the Glycine Receptor
Several posttranslational modifications act in concert to regulate gephyrin scaffolding and GABAergic transmission
Structure and Pharmacologic Modulation of Inhibitory Glycine Receptors
Control of Ethanol Sensitivity of the Glycine Receptor alpha 3 Subunit by Transmembrane 2, the Intracellular Splice Cassette and C-Terminal Domain
Antihyperalgesia by alpha 2-GABA(A) Receptors Occurs Via a Genuine Spinal Action and Does Not Involve Supraspinal Sites
Antihyperalgesia by α2-GABAA receptors occurs via a genuine spinal action and does not involve supraspinal sites.
Ischemia-like oxygen and glucose deprivation mediates down-regulation of cell surface γ-aminobutyric acidB receptors via the endoplasmic reticulum (ER) stress-induced transcription factor CCAAT/enhancer-binding protein (C/EBP)-homologous protein (CHOP).
Endoplasmic reticulum-associated degradation controls cell surface expression of γ-aminobutyric acid, type B receptors.
Extracellular signal-regulated kinase and glycogen synthase kinase 3β regulate gephyrin postsynaptic aggregation and GABAergic synaptic function in a calpain-dependent mechanism.
Chronic pain states: pharmacological strategies to restore diminished inhibitory spinal pain control.
Fast synaptic inhibition in spinal sensory processing and pain control.
The Basic Property of Lys385 Is Important for Potentiation of the Human alpha 1 Glycine Receptor by Ethanol
A Single Phenylalanine Residue in the Main Intracellular Loop of alpha 1 gamma-Aminobutyric Acid Type A and Glycine Receptors Influences Their Sensitivity to Propofol
Activated G Protein alpha(s) Subunits Increase the Ethanol Sensitivity of Human Glycine Receptors
Allosteric modulation of glycine receptors.
Molecular sites for the positive allosteric modulation of glycine receptors by endocannabinoids.
Potentiation and inhibition of glycine receptors by tutin
Regulation of GABAergic synapse formation and plasticity by GSK3beta-dependent phosphorylation of gephyrin.
Molecular Requirements for Ethanol Differential Allosteric Modulation of Glycine Receptors Based on Selective G beta gamma Modulation
Blockade of ethanol-induced potentiation of glycine receptors by a peptide that interferes with Gbetagamma binding.
A selective G betagamma-linked intracellular mechanism for modulation of a ligand-gated ion channel by ethanol.
Molecular determinants for G protein betagamma modulation of ionotropic glycine receptors.
Modulation of glycine-activated ion channel function by G-protein betagamma subunits.
GABA(A) receptors as molecular sites of ethanol action. Direct or indirect actions?
Glycine receptors involved in synaptic transmission are selectively regulated by the cytoskeleton in mouse spinal neurons.

ConferencePoster (17)

Identification of molecular sites associated with the modulation of the glycine receptor by the natural alkaloid gelsemine
Modulation of recombinant and native glycine receptors by Gelsemium genus alkaloids
Molecular mechanisms underlying the functional inhibition of the glycine receptor alpha3 subunit by PKA-mediated phosphorylation
Molecular sites for the modulation of glycine receptors by the analgesic alkaloid gelsemine
Relevance of the S346 residue for the functional modulation of the glycine receptor alfa3 subunit by protein kinase A
The alkaloids Gelsemine and Koumine modify the function of native and spinal glycine receptors
Characterization of a molecular site for the modulation of the glycine receptor alpha3 subunit by 2,6-di-tert-butylphenol
Conformation-specific modulation of synaptic alpha3-containing glycine receptors alleviates chronic inflammatory pain
Effects of the alkaloid gelsemine on recombinant glycine receptors
Exploring the molecular mechanisms underlying the functional inhibition of the glycine receptor alpha3 subunit by PKA-mediated phosphorylation
Modulation of spinal glycine receptors by the alkaloid gelsemine
Molecular sites for the modulation of the glycine receptor alpha3 by 2,6-di-tert-butylphenol
Functional effects of the alkaloid gelsemine on glycine receptor subtypes
Molecular sites for glycine receptor modulation by propofol analogs
Pharmacological modulation of spinal glycine receptors in chronic pain
Pharmacological modulation of spinal synaptic alpha3-containing glycine receptors in inflammatory pain
Phospho-specific potentiation of synaptic heteromeric alpha3-glycine receptors by 2,6-di-tert-butylphenol

ConferenceProceedingWhole (1)

State-dependent modulation of spinal glycine receptors

Proyecto (14)

Targeting glycine receptors for the treatment of chronic pain, hyperekplexia and anxiety: development of novel modulators based on recent structural and pharmacological insights
Deciphering the functional and structural properties of the large intracellular domain of the pentameric ligand gated receptors
Understanding ALS Disease Mechanisms using human induced pluripotent stem cells derived motor neurons (iMNs)
“Deciphering the functional and structural properties of the large intracellular domain of the pentameric ligand gated receptors”
“Understanding ALS Disease Mechanisms using human induced pluripotent stem cells derived motor neurons (iMNs).”
Characterization of glycine receptor molecular determinants and alcohol depressant action
Characterization of Glycine Receptor Molecular Determinants and Alcohol Depressant Action
Modulation of spinal glycine receptor subtypes as a strategy against pain sensitization
MODULATION OF SPINAL GLYCINE RECEPTOR SUBTYPES AS A STRATEGY AGAINST PAIN SENSITIZATION
“Molecular Determinants for Glycine Receptor Allosteric Modulation by Cannabinoid Ligands”
Molecular Determinants for Glycine Receptor Allosteric Modulation by Cannabinoid Ligands”
“ Control of Spinal Pain Processing by GABAA and Strychnine-Sensitive Glycine Receptors”
“Modulation of glycine receptor by ethanol”
Regulación de Receptores de Glicina por Proteinas G y etanol

Review (2)

Pentameric Ligand-Gated Ion Channels as Pharmacological Targets Against Chronic Pain
Glycine receptors and glycine transporters: targets for novel analgesics?
64
Gonzalo Yévenes

Associate Professor

Universidad de Concepcion

Concepcion, Chile

12
JORGE FUENTEALBA

Dean

Physiology

UNIVERISDAD DE CONCEPCION

Concepcion, Chile

10
JOSE GUZMAN

Full professor

Fisiología

Universidad de Concepción

Concepcion, Chile

9
Luis Aguayo

Full Professor

Department of Physiology

Universidad de Concepcion

Concepcion, Chile

9
Carlos Burgos

Profesor Asistente

Fisiología

UNIVERSIDAD DE CONCEPCION

Concepción, Chile

9
Gustavo Moraga

Profesor Asistente

Departamento de Fisiología

Universidad De Concepción

Concepción, Chile

7
Patricio Castro

profesor asistente

fisiologia

UNIVERSIDAD Concepcion

concepcion, Chile

4
Gustavo Moraga

Assistant Professor

UNIVERSIDAD DE CONCEPCION

Chile

3
Ana Marileo

Tesista de Doctorado

De Fisiología

Universidad de Concepción

Concepción, Chile

3
Carola Muñoz

Profesor Asistente

Fisiología

UNIVERSIDAD DE CONCEPCION

Concepcion, Chile

3
Pamela Godoy

Colaboradora académica

Fisiología

Universidad de Concepción

Concepcion, Chile

2
Jessica Panes

Alumna de Doctorado

Fisiología

Universidad de Concepción

Concepcion, Chile

2
Victoria San Martín

Tesista Doctorado

Fisiologia

Universidad de Concepción

Concepción, Chile

2
Oscar Ramírez

Estudiante de Doctorado

Fisiología

Universidad de Concepción

Concepción, Chile

2
Maximiliano Figueroa

Assstant Professor

Universidad de Concepción

Concepción, Chile

2
Javiera Gavilán

Estudiante de Doctorado

Fisiología

Universidad de Concepción

Concepcion, Chile

2
Veronica Jimenez

Assistant Professor

Chemistry

Universidad Andres Bello

Talcahuano, Chile

2
Claudia Perez

Academic

Botany

University of Concepción

Concepción, Chile

2
Carola Díaz

Investigadora Fondecyt Postdoctoral

Departamento de Química

Universidad Andrés Bello

Talcahuano, Chile

2
Maximiliano Figueroa

Profesor Asociado

Bioquímica y Biología Molecular

UNIVERSIDAD DE CONCEPCIÓN

Concepción, Chile

2
Joel Alderete

Full Professor

Universidad de Talca

Talca, Chile

1
Pablo Murath

PhDc y COLABORADOR ACADÉMICO

CIENCIA Y TECNOLOGÍA DE LOS ALIMENTOS

UNIVERSIDAD DE CONCEPCIÓN

Concepción , Chile

1
Trinidad Mariqueo

Profesor Conferenciante

Escuela de Medicina

Universidad de Talca

Talca, Chile

1
Luis Barraza

ACADEMICO-INVESTIGADOR

DEPARTAMENTO DE CIENCIAS QUIMICAS

UNIVERSIDAD DE ANDRES BELLO

Concepción, Chile

1
JOSE BECERRA

Professor

Botany Department

UNIVERSIDAD DE CONCEPCIÓN

Concepción, Chile

1
Monica Carrasco

Profesor Asociado

Escuela de Medicina

UNIVERSIDAD DE TALCA

Talca, Chile

1
Patricio Godoy

Group leader

System sToxicology

Leibniz Research Centre for Working Environment and Human Factors at the TU Dortmund

Dortmund, Alemania

1
Claudio Coddou

Profesor Asociado

Ciencias Biomédicas

Universidad Católica del Norte

Coquimbo, Chile

1
Ramón Sotomayor

Full Professor

Institute of Physiology

UNIVERSIDAD DE VALPARAÍSO, FACULTAD DE CIENCIAS, DEPARTAMENTO DE FISIOLOGÍA

Valparaíso, Chile

1
Luisa Bascuñán

Profesora asistente

Botánica

Universidad de Concepción

Concepción, Chile

1
Andrea Sanchez

Profesor Asociado

Bioquímica Clínica e Inmunología

UNIVERSIDAD DE CONCEPCION

concepcion, Chile

1
Guillermo Díaz

Académico

Química Farmacológica y Toxicológica

UNIVERSIDAD DE CHILE, FACULTAD DE CIENCIAS QUÍMICAS Y FARMACÉUTICAS

Santiago, Chile

1
Daniela Mennickent

Colaboradora académica

Departamento de Análisis Instrumental

Universidad de Concepción

Concepción, Chile