Man

Claudio Eduardo Coddou Alvarez

Profesor Asociado

Universidad Católica del Norte

Coquimbo, Chile

Líneas de Investigación


P2X receptors; Ligand-gated ionic channels, purinergic signaling in cancer, purinergic signaling in pain

Educación

  •  Ciencias Biológicas, mención Ciencias Fisiológicas, PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE. Chile, 2007
  •  Ciencias Biológicas, PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE. Chile, 2000

Experiencia Académica

  •   Pofresor Asociado Full Time

    UNIVERSIDAD CATOLICA DEL NORTE

    Medicina

    Coquimbo, Chile

    2013 - A la fecha

  •   Postdoctorado Other

    UNIVERSIDAD DE SANTIAGO DE CHILE

    Química y Biología

    Santiago, Chile

    2007 - 2008

Experiencia Profesional

  •   Postdoctorado Full Time

    Universidad de Santiago de Chile

    Santiago, Chile

    2007 - 2008

  •   Postdoctoral fellow Full Time

    National Institutes of Healt

    Bethesda, Estados Unidos

    2009 - 2013


 

Article (26)

Altered Glutaminase 1 Activity During Neurulation and Its Potential Implications in Neural Tube Defects
Characterization of the antagonist actions of 5-BDBD at the rat P2X4 receptor
Differential Effects of Purinergic Signaling in Gastric Cancer-Derived Cells Through P2Y and P2X Receptors
Divalent metal modulation of Japanese flounder (Paralichthys olivaceus) purinergic P2X7 receptor
Opposing Roles of Calcium and Intracellular ATP on Gating of the Purinergic P2X2 Receptor Channel
Cyclin-dependent kinase 5 modulates the P2X2a receptor channel gating through phosphorylation of C-terminal threonine 372
Role of domain calcium in purinergic P2X2 receptor channel desensitization
Molecular Characterization and Expression Analysis of ATP-Gated P2X7 Receptor Involved in Japanese Flounder (Paralichthys olivaceus) Innate Immune Response
Gating properties of the P2X2a and P2X2b receptor channels: Experiments and mathematical modeling
Small Molecule Positive Allosteric Modulation of TRPV1 Activation by Vanilloids and Acidic pH
Allosteric modulation of ATP-gated P2X receptor channels
Lipopolysaccharide Inhibits the Channel Activity of the P2X7 Receptor
Oxidative Damage in Lymphocytes of Copper Smelter Workers Correlated to Higher Levels of Excreted Arsenic
Alterations in cholinergic sensitivity of respiratory neurons induced by pre-natal nicotine: a mechanism for respiratory dysfunction in neonatal mice
Reactive Oxygen Species Potentiate the P2X(2) Receptor Activity through Intracellular Cys(430)
Prenatal to Early Postnatal Nicotine Exposure Impairs Central Chemoreception and Modifies Breathing Pattern in Mouse Neonates: A Probable Link to Sudden Infant Death Syndrome
The release of sympathetic neurotransmitters is impaired in aged rats after an inflammatory stimulus: A possible link between cytokine production and sympathetic transmission
Differential role of extracellular histidines in copper, zinc, magnesium and proton modulation of the P2X(7) purinergic receptor
Dissecting the facilitator and inhibitor allosteric metal sites of the P2X(4) receptor channel - Critical roles of Cys(132) for zinc potentiation and Asp(138) for copper inhibition
Extracellular histidine residues identify common structural determinants in the copper/zinc P2X(2) receptor modulation
Heavy metals modulate the activity of the purinergic P2X(4) receptor
Action of nereistoxin on recombinant neuronal nicotinic acetylcholine receptors expressed in Xenopus laevis oocytes
Histidine 140 plays a key role in the inhibitory modulation of the P2X(4) nucleotide receptor by copper but not zinc
Neuromodulator role of zinc and copper during prolonged ATP applications to P2X(4) purinoceptors
The hypolipidemic drug metabolites nafenopin-CoA and ciprofibroyl-CoA are competitive P2Y(1) receptor antagonists
Formation of camosine-Cu(II) complexes prevents and reverts the inhibitory action of copper in P2X(4) and P2X(7) receptors

Abstract (5)

PURINERGIC SIGNALLING OF PRIMARY CULTURES FROM GASTRIC CANCER BIOPSIES
Intracellular cys-430 is a target for mercury and reactive oxygen species in the P2X2 purinoceptor channel
Ivermectin is a selective modulator of the purinergic P2X(4) receptor
Carnosine, a brain dipeptide selectively blocks copper but not zinc modulation in P2X-ATP receptors
Modulation of the P2X4 receptor by divalent metals

Proyecto (4)

ROLE OF PURINERGIC SIGNALING ON THE PATHOPHYSIOLOGY OF GASTRIC CANCER
Adquisición Microscopio Confocal para investigación básica y aplicada en Biomedicina
Articulación y puesta en marcha de un Centro de Referencia de Salud Laboral y Ambiental de la Región de Coquimbo
Loan of Scientific equipment for Research, "Regulation of P2X receptors by phosphorylation and dephosphorylation"

Review (3)

Regulation of ATP-Gated P2X Channels: From Redox Signaling to Interactions with Other Proteins
Activation and Regulation of Purinergic P2X Receptor Channels
Trace metals in the brain: allosteric modulators of ligand-gated receptor channels, the case of ATP-gated P2X receptors
33
Claudio Coddou

Profesor Asociado

Ciencias Biomédicas

Universidad Católica del Norte

Coquimbo, Chile

31
Claudio Coddou

Profesor Asociado

Departamento de Ciencias Biomédicas

Universidad Católica del Norte

Coquimbo, Chile

9
Claudio Acuña

Profesosr Asociado

Biología

UNIVERSIDAD DE SANTIAGO DE CHILE

Santiago, Chile

3
Carmen Imarai

Profesor Titular

Biología

UNIVERSIDAD DE SANTIAGO DE CHILE

Santiago, Chile

3
Bernardo Morales

Profesor titular

Biologia

Universidad de Santiago de Chile

Santiago, Chile

3
Ricardo Fernandez

Profesor Asociado A

Salud

Universidad de Los Lagos

Osorno, Chile

2
Kevin Maisey

Profesor Asistente

Centro de Biotecnología Acuícola

UNIVERSIDAD DE SANTIAGO DE CHILE

Santiago, Chile

2
Eduardo Bravo

University of Iowa

Iowa City, Estados Unidos

2
Jaime Eugenin

Full Professor

Biology

Universidad de Santiago de Chile

Santiago, Chile

2
Rommy von Bernhardi

Full Professor

Neurology

DEPT. NEUROLOGY, FAC. MEDICINE PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

2
Ricardo Fernández

Associate Professor

Health

Universidad de Los Lagos

Osorno, Chile

2
Darwin Leiva

Assistant professor

Biology

Universidad de Santiago de Chile

Santiago, Chile

2
Jorge Escobar

PONTIFICIA UNIVERSIDAD CATÓLICA DE VALPARAÍSO

Valparaíso, Chile

2
SEBASTIAN RAMIREZ

Encargado de Laboratorio

Ciencias Biomédicas

UNIVERSIDAD CATÓLICA DEL NORTE

Coquimbo, Chile

2
ALEXIS ASPEE

Profesor Titular

Ciencias del Ambiente

UNIVERSIDAD DE SANTIAGO DE CHILE

Santiago, Chile

2
Margarita Montoya

Profesor Asociado

Biología

UNIVERSIDAD DE SANTIAGO DE CHILE, FACULTAD DE QUÍMICA Y BIOLOGÍA

Santiago, Chile

2
Alejandro Escobar

assistant professor

Institute for Research in Dental Sciences

UNIVERSIDAD DE CHILE

Santiago, Chile

1
Juan Madariaga

Jefe Unidad

Hospital Coquimbo

Coquimbo, Chile

1
Patricio Castro

profesor asistente

fisiologia

UNIVERSIDAD Concepcion

concepcion, Chile

1
Maria Hevia

Prosefora

Ciencias Biomedicas

Universidad Cátolica del Norte

Coquimbo, Chile

1
Miguel Reyes

Full Professor

Facultad de Ciencias Médicas

UNIVERSIDAD DE SANTIAGO DE CHILE, FACULTAD DE CIENCIAS MÉDICAS, ESCUELA DE MEDICINA

Santiago, Chile

1
Lorena Varela

Assistant Professor

Biological Sciences

Universidad Andres Bello

Santiago, Chile

1
Maria Godoy

Coordinadora Científica

ANID

Santiago, Chile

1
Victoria Espinosa

Academica titular, Vicedecana de Investigación FACIMED

Facultad de Ciencias Medicas

UNIVERSIDAD DE SANTIAGO DE CHILE

Santiago, Chile

1
Antonello Penna

Profesor Asociado

Anestesiología y Medicina Perioperatoria

Universidad de Chile

Santiago, Chile

1
Erwin de la Fuente

PROFESOR/INVESTIGADOR

Ciencias Biomedicas

UNIVERSIDAD CATOLICA DEL NORTE

Coquimbo, Chile

1
Giuliano Bernal

Profesor Titular

Ciencias Biomédicas

UNIVERSIDAD CATÓLICA DEL NORTE

Coquimbo, Chile

1
Jocelyn Brito

Lab manager

Instituto de Ciencias Naturales Alexander von Humboldt

Universidad de Antofagasta

Antofagasta, Chile

1
Rodrigo Sandoval

Director de departamento

Ciencias Biomédicas

UNIVERSIDAD CATOLICA DEL NORTE

Coquimbo, Chile

1
Felipe Gordillo

UNIVERSIDAD CATÒLICA DEL MAULE

Talca, Chile

1
Antonello Penna

Profesor Asociado

UNIVERSIDAD DE CHILE

Santiago, Chile

1
Mauricio Reyna

Asistente de Investigación

Departamento de Ciencias Biomédicas

Universidad Católica del Norte

Coquimbo, Chile