Man

Claudio Eduardo Coddou Alvarez

Profesor Asociado

Universidad Católica del Norte

Coquimbo, Chile

Líneas de Investigación


P2X receptors; Ligand-gated ionic channels, purinergic signaling in cancer, purinergic signaling in pain

Educación

  •  Ciencias Biológicas, mención Ciencias Fisiológicas, PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE. Chile, 2007
  •  Ciencias Biológicas, PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE. Chile, 2000

Experiencia Académica

  •   Pofresor Asociado Full Time

    UNIVERSIDAD CATOLICA DEL NORTE

    Medicina

    Coquimbo, Chile

    2013 - A la fecha

  •   Postdoctorado Other

    UNIVERSIDAD DE SANTIAGO DE CHILE

    Química y Biología

    Santiago, Chile

    2007 - 2008

Experiencia Profesional

  •   Postdoctorado Full Time

    Universidad de Santiago de Chile

    Santiago, Chile

    2007 - 2008

  •   Postdoctoral fellow Full Time

    National Institutes of Healt

    Bethesda, Estados Unidos

    2009 - 2013


 

Article (36)

Activation of Intra-nodose Ganglion P2X7 Receptors Elicit Increases in Neuronal Activity

Alcayaga, Julio; Vera, Jorge; Covarrubias, Alejandra A. A.; Retamal, Mauricio A. A.

Article ISI
CELLULAR AND MOLECULAR NEUROBIOLOGY  (2023)

Understanding the Role of ATP Release through Connexins Hemichannels during Neurulation

Mariana Tovar, Lina; Felipe Burgos, Carlos; Catrupay, Claudio; Castro, Patricio A. A.

Article ISI
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES  (2023)

Inhibition of Caco-2 and MCF-7 cancer cells using chalcones: synthesis, biological evaluation and computational study

Aguilar, Luis F.

Article ISI
NATURAL PRODUCT RESEARCH  (2022)

Itch in Lichen Simplex Chronicus Is Associated with Localized Small Fiber Neuropathy

Sandoval, Mauricio; Parra, Julio; Rojas-Lechuga, Maria Jesus; Bennett, David L. H.

Article ISI
JOURNAL OF INVESTIGATIVE DERMATOLOGY  (2022)

QSAR-driven synthesis of antiproliferative chalcones against SH-SY5Y cancer cells: Design, biological evaluation, and redesign

Covarrubias, Alejandra A.; Aguilar, Luis F.; Mella, Jaime; Cuellar, Mauricio A.

Article ISI
ARCHIV DER PHARMAZIE  (2022)

Resveratrol-Schiff Base Hybrid Compounds with Selective Antibacterial Activity: Synthesis, Biological Activity, and Computational Study

Leyton, Patricio; Aguilar, Luis F.

Article ISI
MICROORGANISMS  (2022)

Roles of the Unsaturated Fatty Acid Docosahexaenoic Acid in the Central Nervous System: Molecular and Cellular Insights

Petermann, Ana B.

Article ISI
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES  (2022)

Transactivation of receptor tyrosine kinases by purinergic P2Y and adenosine receptors

Vazquez-Cuevas, F. G.; Reyna-Jeldes, M.; Velazquez-Miranda, E.; Coddou, C.

Article ISI
PURINERGIC SIGNALLING  (2022)

Purinergic P2Y2 and P2X4 Receptors Are Involved in the Epithelial-Mesenchymal Transition and Metastatic Potential of Gastric Cancer Derived Cell Lines

Velazquez-Miranda, Erandi; Vazquez-Cuevas, Francisco G.; CODDOU, Claudio

Article ISI
PHARMACEUTICS  (2021)

The Omega-3 fatty acid docosahexaenoic acid selectively induces apoptosis in tumor-derived cells and suppress tumor growth in gastric cancer

Castro, Patricio; CODDOU, Claudio

Article ISI
EUROPEAN JOURNAL OF PHARMACOLOGY  (2021)

Altered Glutaminase 1 Activity During Neurulation and Its Potential Implications in Neural Tube Defects

Retamal, Claudio; CODDOU, Claudio; Castro, Patricio A.

Article ISI
FRONTIERS IN PHARMACOLOGY  (2020)

Characterization of the antagonist actions of 5-BDBD at the rat P2X4 receptor

CODDOU, Claudio; Sandoval, Rodrigo; Jose Hevia, Maria; Stojilkovic, Stanko S.

Article ISI SCOPUS
NEUROSCIENCE LETTERS  (2019)

Differential Effects of Purinergic Signaling in Gastric Cancer-Derived Cells Through P2Y and P2X Receptors

Castro, Patricio; Andres Madariaga, Juan; CODDOU, Claudio

Article ISI SCOPUS
FRONTIERS IN PHARMACOLOGY  (2019)

Divalent metal modulation of Japanese flounder (Paralichthys olivaceus) purinergic P2X7 receptor

Chen, XL; Coddou, C.

Article ISI SCOPUS
FEBS OPEN BIO  (2018)

Opposing Roles of Calcium and Intracellular ATP on Gating of the Purinergic P2X2 Receptor Channel

Rokic, MB; Tomic M.; Stojilkovic, SS; Coddou, C.

Article ISI SCOPUS
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES  (2018)

Cyclin-dependent kinase 5 modulates the P2X2a receptor channel gating through phosphorylation of C-terminal threonine 372

Coddou, Claudio; Sandoval, Rodrigo; Castro, Patricio; Lazcano, Pablo; Hevia, María José; Rokic, Milos; Hall, Bradford; Terse, Anita; Gonzalez-Billault, Christian; Kulkarni, Ashok B.; Stojilkovic, Stanko S.; Utreras, Elias

Article
Pain  (2017)

Role of domain calcium in purinergic P2X2 receptor channel desensitization

Coddou, C.; Yan, ZH; Stojilkovic, SS

Article ISI SCOPUS
American Journal of Physiology - Cell Physiology  (2015)

Molecular Characterization and Expression Analysis of ATP-Gated P2X7 Receptor Involved in Japanese Flounder (Paralichthys olivaceus) Innate Immune Response

Li, S; Li, XJ; Coddou, C.; Geng, XY; Wei, JL; Sun, JS

Article ISI SCOPUS
PLOS ONE  (2014)

Gating properties of the P2X2a and P2X2b receptor channels: Experiments and mathematical modeling

Khadra, A; Yan, ZH; Coddou, C.; Tomic M.; Sherman, A; Stojilkovic, SS

Article ISI
JOURNAL OF GENERAL PHYSIOLOGY  (2012)

Small Molecule Positive Allosteric Modulation of TRPV1 Activation by Vanilloids and Acidic pH

Kaszas, K; Keller, JM; Coddou, C.; Mishra, SK; Hoon, MA; Stojilkovic S; Jacobson, KA; Iadarola, MJ

Article ISI
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS  (2012)

Allosteric modulation of ATP-gated P2X receptor channels

Coddou, C.; Stojilkovic, SS; Huidobro-Toro, JP

Article ISI SCOPUS
Reviews in the Neurosciences  (2011)

Lipopolysaccharide Inhibits the Channel Activity of the P2X7 Receptor

leiva-salcedo, e; Coddou, C.; Rodríguez FE; Penna, A; López, X; Neira, T; Fernández, R; Imarai, M.; Rios, M.; Escobar, J; et al.

Article ISI SCOPUS
Mediators of Inflammation  (2011)

Oxidative Damage in Lymphocytes of Copper Smelter Workers Correlated to Higher Levels of Excreted Arsenic

Escobar, J; Varela-Nallar, L; Coddou, C.; Nelson, P.; Maisey, K.; Valdes, D.; Aspée A.; Espinosa, V; Rozas, C.; Montoya, M; et al.

Article ISI SCOPUS
Mediators of Inflammation  (2010)

Alterations in cholinergic sensitivity of respiratory neurons induced by pre-natal nicotine: a mechanism for respiratory dysfunction in neonatal mice

Coddou, C.; Bravo, E; Eugenín J.

Article ISI SCOPUS
PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES  (2009)

Reactive Oxygen Species Potentiate the P2X(2) Receptor Activity through Intracellular Cys(430)

Coddou, C.; Codocedo JF; Li, S; Lillo JG; Acuna-Castillo, C; Bull, P; Stojilkovic, SS; Huidobro-Toro, JP

Article ISI SCOPUS
JOURNAL OF NEUROSCIENCE  (2009)

Prenatal to Early Postnatal Nicotine Exposure Impairs Central Chemoreception and Modifies Breathing Pattern in Mouse Neonates: A Probable Link to Sudden Infant Death Syndrome

Eugenín J.; Otarola, M; Bravo, E; Coddou, C.; Cerpa, V; Reyes-Parada, M; Llona I.; von Bernhardi R.

Article ISI SCOPUS
JOURNAL OF NEUROSCIENCE  (2008)

The release of sympathetic neurotransmitters is impaired in aged rats after an inflammatory stimulus: A possible link between cytokine production and sympathetic transmission

Donoso, V; Gomez, CR; Orriantia, MA; Pérez, V; Torres, C; Coddou, C.; Nelson, P.; Maisey, K.; Morales, B; Fernández, R; et al.

Article ISI SCOPUS
MECHANISMS OF AGEING AND DEVELOPMENT  (2008)

Differential role of extracellular histidines in copper, zinc, magnesium and proton modulation of the P2X(7) purinergic receptor

Acuna-Castillo, C; Coddou, C.; Bull, P; Brito, J; Huidobro-Toro, JP

Article ISI SCOPUS
JOURNAL OF NEUROCHEMISTRY  (2007)

Dissecting the facilitator and inhibitor allosteric metal sites of the P2X(4) receptor channel - Critical roles of Cys(132) for zinc potentiation and Asp(138) for copper inhibition

Coddou, C.; Acuna-Castillo, C; Bull, P; Huidobro-Toro, JP

Article ISI SCOPUS
JOURNAL OF BIOLOGICAL CHEMISTRY  (2007)

Extracellular histidine residues identify common structural determinants in the copper/zinc P2X(2) receptor modulation

Lorca RA; Coddou, C.; Gazitua, MC; Bull, P; Arredondo, C; Huidobro-Toro, JP

Article ISI SCOPUS
JOURNAL OF NEUROCHEMISTRY  (2005)

Heavy metals modulate the activity of the purinergic P2X(4) receptor

Coddou, C.; Lorca RA; Acuna-Castillo, C; Grauso, M; Rassendren, F; Huidobro-Toro, JP

Article ISI SCOPUS
TOXICOLOGY AND APPLIED PHARMACOLOGY  (2005)

Action of nereistoxin on recombinant neuronal nicotinic acetylcholine receptors expressed in Xenopus laevis oocytes

Delpech V.R.; Coddou, C.; Sattelle D.B.; Ihara M.; Matsuda, K

Article SCOPUS
Invertebrate Neuroscience  (2003)

Histidine 140 plays a key role in the inhibitory modulation of the P2X(4) nucleotide receptor by copper but not zinc

Coddou, C.; Morales, B; Gonzalez, J; Grauso, M; Gordillo F.; Bull, P; Rassendren, F; Huidobro-Toro, JP

Article ISI
JOURNAL OF BIOLOGICAL CHEMISTRY  (2003)

Neuromodulator role of zinc and copper during prolonged ATP applications to P2X(4) purinoceptors

Coddou, C.; Morales, B; Huidobro-Toro, JP

Article ISI SCOPUS
EUROPEAN JOURNAL OF PHARMACOLOGY  (2003)

The hypolipidemic drug metabolites nafenopin-CoA and ciprofibroyl-CoA are competitive P2Y(1) receptor antagonists

Coddou, C.; Loyola, G; Boyer, JL; Bronfman, M; Huidobro-Toro, JP

Article ISI SCOPUS
FEBS LETTERS  (2003)

Formation of camosine-Cu(II) complexes prevents and reverts the inhibitory action of copper in P2X(4) and P2X(7) receptors

Coddou, C.; Villalobos, C; Gonzalez, J; Acuna-Castillo, C; Loeb, B; Huidobro-Toro, JP

Article ISI
JOURNAL OF NEUROCHEMISTRY  (2002)

Abstract (5)

PURINERGIC SIGNALLING OF PRIMARY CULTURES FROM GASTRIC CANCER BIOPSIES

Coddou, C.; Hevia, MJ

Abstract ISI
 (2018)

Intracellular cys-430 is a target for mercury and reactive oxygen species in the P2X2 purinoceptor channel

Huidobro-Toro, JP; Coddou, C.; Bull, P

Abstract ISI
ACTA PHARMACOLOGICA SINICA  (2006)

Ivermectin is a selective modulator of the purinergic P2X(4) receptor

Godoy MF; Coddou, C.; Huidobro-Toro, JP

Abstract ISI
PLACENTA  (2006)

Carnosine, a brain dipeptide selectively blocks copper but not zinc modulation in P2X-ATP receptors

Coddou, C.; Villalobos, C; Huidobro-Toro, JP

Abstract ISI
JOURNAL OF NEUROCHEMISTRY  (2001)

Modulation of the P2X4 receptor by divalent metals

Coddou, C.; Acuña, C; Huidobro-Toro, JP

Abstract ISI
JOURNAL OF PHYSIOLOGY-LONDON  (2000)

Proyecto (4)

ROLE OF PURINERGIC SIGNALING ON THE PATHOPHYSIOLOGY OF GASTRIC CANCER

FONDECYT (1161490)

Proyecto
2016-2020
Inv. Responsable

Adquisición Microscopio Confocal para investigación básica y aplicada en Biomedicina

FONDEQUIP (EQM140100)

Proyecto
2014-2016
Inv. Responsable

Articulación y puesta en marcha de un Centro de Referencia de Salud Laboral y Ambiental de la Región de Coquimbo

FIC-R

Proyecto
2014-2016
Coinvestigador(a)

Loan of Scientific equipment for Research, "Regulation of P2X receptors by phosphorylation and dephosphorylation"

NIH (NIH Loan L-013-013-011)

Proyecto
2013-2016
Investigador(a)

Review (3)

Regulation of ATP-Gated P2X Channels: From Redox Signaling to Interactions with Other Proteins

Stojilkovic, SS; leiva-salcedo, e; Rokic, MB; Coddou, C.

Review ISI SCOPUS
ANTIOXIDANTS & REDOX SIGNALING  (2014)

Activation and Regulation of Purinergic P2X Receptor Channels

Coddou, C.; Yan, Z; Obsil, T.; Stojilkovic, S. S.

Review ISI SCOPUS
Pharmacological Reviews  (2011)

Trace metals in the brain: allosteric modulators of ligand-gated receptor channels, the case of ATP-gated P2X receptors

Huidobro-Toro, JP; Lorca RA; Coddou, C.

Review ISI
EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS  (2008)

2
Rommy von Bernhardi

Full Professor

Neurology

DEPT. NEUROLOGY, FAC. MEDICINE PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

1
Mauricio Cuellar

UNIVERSIDAD DE VALPARAÍSO

Valparaíso, Chile

2
Ricardo Fernández

Associate Professor

Salud

Universidad de Los Lagos

Osorno, Chile

1
Julio Alcayaga

Profesor Titular

Biología

UNIVERSIDAD DE CHILE, FAC. CIENCIAS, DEPTO. BIOLOGÍA

Santiago, Chile

1
Rodrigo Sandoval

Director de departamento

Ciencias Biomédicas

UNIVERSIDAD CATOLICA DEL NORTE

Coquimbo, Chile

1
JUAN VILLENA

FULL PROFESSOR

ANATOMY

FACULTA DE MEDICINA. UNIVERSIDAD DE VALPARAISO

VIÑA DEL MAR, Chile

1
JORGE FUENTEALBA

Dean

Physiology

UNIVERISDAD DE CONCEPCION

Concepcion, Chile

2
Jaime Eugenin

Full Professor

Biology

Universidad de Santiago de Chile

Santiago, Chile

1
Miguel Reyes

Full Professor

Facultad de Ciencias Médicas

UNIVERSIDAD DE SANTIAGO DE CHILE, FACULTAD DE CIENCIAS MÉDICAS, ESCUELA DE MEDICINA

Santiago, Chile

9
Claudio Acuña

Profesosr Asociado

Biología

UNIVERSIDAD DE SANTIAGO DE CHILE

Santiago, Chile

3
Bernardo Morales

Profesor titular

Biologia

Universidad de Santiago de Chile

Santiago, Chile

2
Alejandro Escobar

assistant professor

Institute for Research in Dental Sciences

UNIVERSIDAD DE CHILE

Santiago, Chile

2
Giuliano Bernal

Profesor Titular

Ciencias Biomédicas

UNIVERSIDAD CATÓLICA DEL NORTE

Coquimbo, Chile

2
Margarita Montoya

Profesor Asociado

Biología

UNIVERSIDAD DE SANTIAGO DE CHILE, FACULTAD DE QUÍMICA Y BIOLOGÍA

Santiago, Chile

3
Carmen Imarai

Profesor Titular

Biología

UNIVERSIDAD DE SANTIAGO DE CHILE

Santiago, Chile

2
ALEXIS ASPEE

Profesor Titular

Ciencias del Ambiente

UNIVERSIDAD DE SANTIAGO DE CHILE

Santiago, Chile

1
Katy Díaz

Investigador Joven

Química

UNIVERSIDAD TÉCNICA FEDERICO SANTA MARÍA

Valparaíso, Chile

2
Jorge Escobar

PONTIFICIA UNIVERSIDAD CATÓLICA DE VALPARAÍSO

Valparaíso, Chile

2
Caroline Weinstein

profesor titular

Facultad de Farmacia

UNIVERSIDAD DE VALPARAÍSO

Valparaíso, Chile

1
Victoria Espinosa

Academica titular, Vicedecana de Investigación FACIMED

Facultad de Ciencias Medicas

UNIVERSIDAD DE SANTIAGO DE CHILE

Santiago, Chile

1
PATRICIO LEYTON

Profesor Asociado

INSTITUTO DE QUÍMICA

PONTIFICIA UNIVERSIDAD CATÓLICA DE VALPARAÍSO

Valparaíso, Chile

43
Claudio Coddou

Profesor Asociado

Ciencias Biomédicas

Universidad Católica del Norte

Coquimbo, Chile

1
Felipe Gordillo

UNIVERSIDAD CATÒLICA DEL MAULE

Talca, Chile

1
Luisa Bascuñán

Profesora asistente

Botánica

Universidad de Concepción

Concepción, Chile

1
Mauricio Retamal

Associate Professor

Programa de Comunicación Celular en Cancer

Universidad del Desarrollo

Santiago, Chile

3
Gonzalo Yévenes

Associate Professor

Universidad de Concepcion

Concepcion, Chile

1
Lorena Varela

Assistant Professor

Biological Sciences

Universidad Andres Bello

Santiago, Chile

2
Eduardo Bravo

University of Iowa

Iowa City, Estados Unidos

1
Antonello Penna

Profesor Asociado

UNIVERSIDAD DE CHILE

Santiago, Chile

1
Patricio Castro

profesor asistente

fisiologia

UNIVERSIDAD Concepcion

concepcion, Chile

1
Gustavo Moraga

Assistant Professor

UNIVERSIDAD DE CONCEPCION

Chile

3
Erwin de la Fuente

PROFESOR ASOCIADO

CIENCIAS BIOMÉDICAS

UNIVERSIDAD CATOLICA DEL NORTE

Coquimbo, Chile

2
Kevin Maisey

Profesor Asistente

Centro de Biotecnología Acuícola

UNIVERSIDAD DE SANTIAGO DE CHILE

Santiago, Chile

3
Marco Mellado

Profesor / Investigador

Facultad de Medicina y Ciencias de la Salud

Universidad Central de Chile

Santiago, Chile

1
Maria Godoy

Jefa de Proyectos Internacionales

Universidad Andrés Bello

Santiago, Chile

1
Antonello Penna

Profesor Asociado

Anestesiología y Medicina Perioperatoria

Universidad de Chile

Santiago, Chile

3
Darwin Leiva

Associate professor

Biology

Universidad de Santiago de Chile

Santiago, Chile

31
Claudio Coddou

Profesor Asociado

Departamento de Ciencias Biomédicas

Universidad Católica del Norte

Coquimbo, Chile

3
Ricardo Fernandez

Profesor Asociado A

Salud

Universidad de Los Lagos

Osorno, Chile

1
JAIME MELLA

PROFESOR ADJUNTO

INSTITUTO DE QUIMICA Y BIOQUIMICA

UNIVERSIDAD DE VALPARAISO

VALPARAISO, Chile

1
CHRISTIAN MANDIOLA

Jefe de los laboratorios Integrados

Ciencias Naturales

UVM

VIÑA DEL MAR, Chile

1
Juan Madariaga

Jefe Unidad

Hospital Coquimbo

Coquimbo, Chile

1
Carlos Jara

Profesor adjunto

Universidad de Valparaíso

Reñaca, Chile

1
Hernan Diaz

1
Jocelyn Brito

Lab manager

Instituto de Ciencias Naturales Alexander von Humboldt

Universidad de Antofagasta

Antofagasta, Chile

2
SEBASTIAN RAMIREZ

Dr(c). Biología Aplicada

Ciencias Biomédicas

UNIVERSIDAD CATÓLICA DEL NORTE

Coquimbo, Chile

1
Maria Hevia

Prosefora

Ciencias Biomedicas

Universidad Cátolica del Norte

Coquimbo, Chile

1
Mauricio Reyna

Asistente de Investigación

Departamento de Ciencias Biomédicas

Universidad Católica del Norte

Coquimbo, Chile

1
Rodrigo Sánchez

Profesor Part-time

Pontificia Universidad Católica de Valparaíso

Valparaíso, Chile

1
Fernanda Espinoza

Encargada administrativa

Fisiología

Pontificia Universidad Católica de Chile

Santiago, Chile

1
Esteban Díaz

Assistant Professor

Universidad Autónoma de Chile

Santiago, Chile

1
DANIEL VALDES

Profesional

Facultad de Química y Biología

Universidad de Santiago de Chile

Santiago , Chile