Man

Claudio Eduardo Coddou Alvarez

Profesor Asociado

Universidad Católica del Norte

Coquimbo, Chile

Líneas de Investigación


P2X receptors; Ligand-gated ionic channels, purinergic signaling in cancer, purinergic signaling in pain

Educación

  •  Ciencias Biológicas, mención Ciencias Fisiológicas, PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE. Chile, 2007
  •  Ciencias Biológicas, PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE. Chile, 2000

Experiencia Académica

  •   Pofresor Asociado Full Time

    UNIVERSIDAD CATOLICA DEL NORTE

    Medicina

    Coquimbo, Chile

    2013 - A la fecha

  •   Postdoctorado Other

    UNIVERSIDAD DE SANTIAGO DE CHILE

    Química y Biología

    Santiago, Chile

    2007 - 2008

Experiencia Profesional

  •   Postdoctorado Full Time

    Universidad de Santiago de Chile

    Santiago, Chile

    2007 - 2008

  •   Postdoctoral fellow Full Time

    National Institutes of Healt

    Bethesda, Estados Unidos

    2009 - 2013


 

Article (36)

Activation of Intra-nodose Ganglion P2X7 Receptors Elicit Increases in Neuronal Activity

Alcayaga, Julio; Vera, Jorge; Reyna-Jeldes, Mauricio; Covarrubias, Alejandra A. A.; Coddou, Claudio; Diaz-Jara, Esteban; Del Rio, Rodrigo; Retamal, Mauricio A. A.

Article ISI
CELLULAR AND MOLECULAR NEUROBIOLOGY  (2023)

Understanding the Role of ATP Release through Connexins Hemichannels during Neurulation

Mariana Tovar, Lina; Felipe Burgos, Carlos; Yevenes, Gonzalo E.; Moraga-Cid, Gustavo; Fuentealba, Jorge; Coddou, Claudio; Bascunan-Godoy, Luisa; Catrupay, Claudio; Torres, Angel; Castro, Patricio A. A.

Article ISI
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES  (2023)

Inhibition of Caco-2 and MCF-7 cancer cells using chalcones: synthesis, biological evaluation and computational study

Mellado, Marco; Reyna-Jeldes, Mauricio; Weinstein-Oppenheimer, Caroline; Coddou, Claudio; Jara-Gutierrez, Carlos; Villena, Joan; Aguilar, Luis F.

Article ISI
NATURAL PRODUCT RESEARCH  (2022)

Itch in Lichen Simplex Chronicus Is Associated with Localized Small Fiber Neuropathy

Sandoval, Mauricio; Parra, Julio; Reyna-Jeldes, Mauricio; Curi-Tuma, Maximiliano; Espinoza, Fernanda; Munoz, Daniela; Rojas-Lechuga, Maria Jesus; Coddou, Claudio; Bennett, David L. H.; Calvo, Margarita

Article ISI
JOURNAL OF INVESTIGATIVE DERMATOLOGY  (2022)

QSAR-driven synthesis of antiproliferative chalcones against SH-SY5Y cancer cells: Design, biological evaluation, and redesign

Mellado, Marco; Reyna-Jeldes, Mauricio; Weinstein-Oppenheimer, Caroline; Covarrubias, Alejandra A.; Aguilar, Luis F.; Coddou, Claudio; Mella, Jaime; Cuellar, Mauricio A.

Article ISI
ARCHIV DER PHARMAZIE  (2022)

Resveratrol-Schiff Base Hybrid Compounds with Selective Antibacterial Activity: Synthesis, Biological Activity, and Computational Study

Sanchez-Gonzalez, Rodrigo; Leyton, Patricio; Aguilar, Luis F.; Reyna-Jeldes, Mauricio; Coddou, Claudio; Diaz, Katy; Mellado, Marco

Article ISI
MICROORGANISMS  (2022)

Roles of the Unsaturated Fatty Acid Docosahexaenoic Acid in the Central Nervous System: Molecular and Cellular Insights

Petermann, Ana B.; Reyna-Jeldes, Mauricio; Ortega, Lorena; Coddou, Claudio; Yevenes, Gonzalo E.

Article ISI
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES  (2022)

Transactivation of receptor tyrosine kinases by purinergic P2Y and adenosine receptors

Vazquez-Cuevas, F. G.; Reyna-Jeldes, M.; Velazquez-Miranda, E.; Coddou, C.

Article ISI
PURINERGIC SIGNALLING  (2022)

Purinergic P2Y2 and P2X4 Receptors Are Involved in the Epithelial-Mesenchymal Transition and Metastatic Potential of Gastric Cancer Derived Cell Lines

Reyna-Jeldes, Mauricio; De la Fuente-Ortega, Erwin; Cerda, Daniela; Velazquez-Miranda, Erandi; Pinto, Katherine; Vazquez-Cuevas, Francisco G.; CODDOU, Claudio

Article ISI
PHARMACEUTICS  (2021)

The Omega-3 fatty acid docosahexaenoic acid selectively induces apoptosis in tumor-derived cells and suppress tumor growth in gastric cancer

Ortega, Lorena; Lobos-Gonzalez, Lorena; Reyna-Jeldes, Mauricio; Cerda, Daniela; De la Fuente-Ortega, Erwin; Castro, Patricio; Bernal, Giuliano; CODDOU, Claudio

Article ISI
EUROPEAN JOURNAL OF PHARMACOLOGY  (2021)

Altered Glutaminase 1 Activity During Neurulation and Its Potential Implications in Neural Tube Defects

Benavides-Rivas, Camila; Tovar, Lina Mariana; Zuniga, Nicolas; Pinto-Borguero, Ingrid; Retamal, Claudio; Yevenes, Gonzalo E.; Moraga-Cid, Gustavo; Fuentealba, Jorge; Guzman, Leonardo; CODDOU, Claudio; Bascunan-Godoy, Luisa; Castro, Patricio A.

Article ISI
FRONTIERS IN PHARMACOLOGY  (2020)

Characterization of the antagonist actions of 5-BDBD at the rat P2X4 receptor

CODDOU, Claudio; Sandoval, Rodrigo; Jose Hevia, Maria; Stojilkovic, Stanko S.

Article ISI SCOPUS
NEUROSCIENCE LETTERS  (2019)

Differential Effects of Purinergic Signaling in Gastric Cancer-Derived Cells Through P2Y and P2X Receptors

Jose Hevia, Maria; Castro, Patricio; Pinto, Katherine; Reyna-Jeldes, Mauricio; Rodriguez-Tirado, Felipe; Robles-Planells, Claudia; Ramirez-Rivera, Sebastian; Andres Madariaga, Juan; Gutierrez, Felipe; Lopez, Javier; Barra, Marcelo; De la Fuente-Ortega, Erwin; Bernal, Giuliano; CODDOU, Claudio

Article ISI SCOPUS
FRONTIERS IN PHARMACOLOGY  (2019)

Divalent metal modulation of Japanese flounder (Paralichthys olivaceus) purinergic P2X7 receptor

Paredes, C; Li, S; Chen, XL; Coddou, C.

Article ISI SCOPUS
FEBS OPEN BIO  (2018)

Opposing Roles of Calcium and Intracellular ATP on Gating of the Purinergic P2X2 Receptor Channel

Rokic, MB; Castro, P; Leiva-Salcedo, E; Tomic M.; Stojilkovic, SS; Coddou, C.

Article ISI SCOPUS
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES  (2018)

Cyclin-dependent kinase 5 modulates the P2X2a receptor channel gating through phosphorylation of C-terminal threonine 372

Coddou, Claudio; Sandoval, Rodrigo; Castro, Patricio; Lazcano, Pablo; Hevia, María José; Rokic, Milos; Hall, Bradford; Terse, Anita; Gonzalez-Billault, Christian; Kulkarni, Ashok B.; Stojilkovic, Stanko S.; Utreras, Elias

Article
Pain  (2017)

Role of domain calcium in purinergic P2X2 receptor channel desensitization

Coddou, C.; Yan, ZH; Stojilkovic, SS

Article ISI SCOPUS
American Journal of Physiology - Cell Physiology  (2015)

Molecular Characterization and Expression Analysis of ATP-Gated P2X7 Receptor Involved in Japanese Flounder (Paralichthys olivaceus) Innate Immune Response

Li S.; Li, XJ; Coddou, C.; Geng, XY; Wei, JL; Sun, JS

Article ISI SCOPUS
PLOS ONE  (2014)

Gating properties of the P2X2a and P2X2b receptor channels: Experiments and mathematical modeling

Khadra, A; Yan, ZH; Coddou, C.; Tomic M.; Sherman, A; Stojilkovic, SS

Article ISI
JOURNAL OF GENERAL PHYSIOLOGY  (2012)

Small Molecule Positive Allosteric Modulation of TRPV1 Activation by Vanilloids and Acidic pH

Kaszas, K; Keller, JM; Coddou, C.; Mishra, SK; Hoon, MA; Stojilkovic S; Jacobson, KA; Iadarola, MJ

Article ISI
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS  (2012)

Allosteric modulation of ATP-gated P2X receptor channels

Coddou, C.; Stojilkovic, SS; Huidobro-Toro, JP

Article ISI SCOPUS
Reviews in the Neurosciences  (2011)

Lipopolysaccharide Inhibits the Channel Activity of the P2X7 Receptor

Leiva-Salcedo, E; Coddou, C.; Rodríguez FE; Penna, A; López, X; Neira, T; Fernandez, R.; Imarai M.; Rios M.; Escobar, J; Montoya, M; Huidobro-Toro, JP; Escobar A.; Acuna-Castillo, C

Article ISI SCOPUS
Mediators of Inflammation  (2011)

Oxidative Damage in Lymphocytes of Copper Smelter Workers Correlated to Higher Levels of Excreted Arsenic

Escobar, J; Varela-Nallar, L; Coddou, C.; Nelson, P.; Maisey, K; Valdes, D.; Aspée A.; Espinosa, V; Rozas C.; Montoya, M; Mandiola C.; Rodríguez FE; Acuna-Castillo, C; Escobar A.; Fernandez, R.; Diáz, H.; Sandoval M.; Imarai M.; Rios M.

Article ISI SCOPUS
Mediators of Inflammation  (2010)

Alterations in cholinergic sensitivity of respiratory neurons induced by pre-natal nicotine: a mechanism for respiratory dysfunction in neonatal mice

Coddou, C.; Bravo, E.; Eugenín J.

Article ISI SCOPUS
PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES  (2009)

Reactive Oxygen Species Potentiate the P2X(2) Receptor Activity through Intracellular Cys(430)

Coddou, C.; Codocedo JF; Li S.; Lillo JG; Acuna-Castillo, C; Bull, P; Stojilkovic, SS; Huidobro-Toro, JP

Article ISI SCOPUS
JOURNAL OF NEUROSCIENCE  (2009)

Prenatal to Early Postnatal Nicotine Exposure Impairs Central Chemoreception and Modifies Breathing Pattern in Mouse Neonates: A Probable Link to Sudden Infant Death Syndrome

Eugenín J.; Otarola, M; Bravo, E.; Coddou, C.; Cerpa, V; Reyes-Parada, M; Llona I.; von Bernhardi R.

Article ISI SCOPUS
JOURNAL OF NEUROSCIENCE  (2008)

The release of sympathetic neurotransmitters is impaired in aged rats after an inflammatory stimulus: A possible link between cytokine production and sympathetic transmission

Donoso, V; Gomez, CR; Orriantia, MA; Pérez V; Torres C.; Coddou, C.; Nelson, P.; Maisey, K; Morales, B; Fernandez, R.; Imarai M.; Huidobro-Toro, JP; Sierra, F; Acuna-Castillo, C

Article ISI SCOPUS
MECHANISMS OF AGEING AND DEVELOPMENT  (2008)

Differential role of extracellular histidines in copper, zinc, magnesium and proton modulation of the P2X(7) purinergic receptor

Acuna-Castillo, C; Coddou, C.; Bull, P; Brito, J; Huidobro-Toro, JP

Article ISI SCOPUS
JOURNAL OF NEUROCHEMISTRY  (2007)

Dissecting the facilitator and inhibitor allosteric metal sites of the P2X(4) receptor channel - Critical roles of Cys(132) for zinc potentiation and Asp(138) for copper inhibition

Coddou, C.; Acuna-Castillo, C; Bull, P; Huidobro-Toro, JP

Article ISI SCOPUS
JOURNAL OF BIOLOGICAL CHEMISTRY  (2007)

Extracellular histidine residues identify common structural determinants in the copper/zinc P2X(2) receptor modulation

Lorca RA; Coddou, C.; Gazitua, MC; Bull, P; Arredondo, C; Huidobro-Toro, JP

Article ISI SCOPUS
JOURNAL OF NEUROCHEMISTRY  (2005)

Heavy metals modulate the activity of the purinergic P2X(4) receptor

Coddou, C.; Lorca RA; Acuna-Castillo, C; Grauso, M; Rassendren, F; Huidobro-Toro, JP

Article ISI SCOPUS
TOXICOLOGY AND APPLIED PHARMACOLOGY  (2005)

Action of nereistoxin on recombinant neuronal nicotinic acetylcholine receptors expressed in Xenopus laevis oocytes

Delpech V.R.; Coddou, C.; Sattelle D.B.; Ihara M.; Matsuda, K

Article SCOPUS
Invertebrate Neuroscience  (2003)

Histidine 140 plays a key role in the inhibitory modulation of the P2X(4) nucleotide receptor by copper but not zinc

Coddou, C.; Morales, B; Gonzalez, J; Grauso, M; Gordillo F.; Bull, P; Rassendren, F; Huidobro-Toro, JP

Article ISI
JOURNAL OF BIOLOGICAL CHEMISTRY  (2003)

Neuromodulator role of zinc and copper during prolonged ATP applications to P2X(4) purinoceptors

Coddou, C.; Morales, B; Huidobro-Toro, JP

Article ISI SCOPUS
EUROPEAN JOURNAL OF PHARMACOLOGY  (2003)

The hypolipidemic drug metabolites nafenopin-CoA and ciprofibroyl-CoA are competitive P2Y(1) receptor antagonists

Coddou, C.; Loyola, G; Boyer, JL; Bronfman, M; Huidobro-Toro, JP

Article ISI SCOPUS
FEBS LETTERS  (2003)

Formation of camosine-Cu(II) complexes prevents and reverts the inhibitory action of copper in P2X(4) and P2X(7) receptors

Coddou, C.; Villalobos C.; Gonzalez, J; Acuna-Castillo, C; Loeb, B; Huidobro-Toro, JP

Article ISI
JOURNAL OF NEUROCHEMISTRY  (2002)

Abstract (5)

PURINERGIC SIGNALLING OF PRIMARY CULTURES FROM GASTRIC CANCER BIOPSIES

Coddou, C.; Hevia, MJ; Gutierrez, F; Bernal, G; Madariaga, JA; De la Fuente, E

Abstract ISI
 (2018)

Intracellular cys-430 is a target for mercury and reactive oxygen species in the P2X2 purinoceptor channel

Huidobro-Toro, JP; Coddou, C.; Bull, P

Abstract ISI
ACTA PHARMACOLOGICA SINICA  (2006)

Ivermectin is a selective modulator of the purinergic P2X(4) receptor

Godoy MF; Coddou, C.; Huidobro-Toro, JP

Abstract ISI
PLACENTA  (2006)

Carnosine, a brain dipeptide selectively blocks copper but not zinc modulation in P2X-ATP receptors

Coddou, C.; Villalobos C.; Huidobro-Toro, JP

Abstract ISI
JOURNAL OF NEUROCHEMISTRY  (2001)

Modulation of the P2X4 receptor by divalent metals

Coddou, C.; Acuna, C; Huidobro-Toro, JP

Abstract ISI
JOURNAL OF PHYSIOLOGY-LONDON  (2000)

Proyecto (4)

ROLE OF PURINERGIC SIGNALING ON THE PATHOPHYSIOLOGY OF GASTRIC CANCER

FONDECYT (1161490)

Proyecto
2016-2020
Inv. Responsable

Adquisición Microscopio Confocal para investigación básica y aplicada en Biomedicina

FONDEQUIP (EQM140100)

Proyecto
2014-2016
Inv. Responsable

Articulación y puesta en marcha de un Centro de Referencia de Salud Laboral y Ambiental de la Región de Coquimbo

FIC-R

Proyecto
2014-2016
Coinvestigador(a)

Loan of Scientific equipment for Research, "Regulation of P2X receptors by phosphorylation and dephosphorylation"

NIH (NIH Loan L-013-013-011)

Proyecto
2013-2016
Investigador(a)

Review (3)

Regulation of ATP-Gated P2X Channels: From Redox Signaling to Interactions with Other Proteins

Stojilkovic, SS; Leiva-Salcedo, E; Rokic, MB; Coddou, C.

Review ISI SCOPUS
ANTIOXIDANTS & REDOX SIGNALING  (2014)

Activation and Regulation of Purinergic P2X Receptor Channels

Coddou, C.; Yan, Z; Obsil, T.; Huidobro-Toro J.P.; Stojilkovic, S. S.

Review ISI SCOPUS
Pharmacological Reviews  (2011)

Trace metals in the brain: allosteric modulators of ligand-gated receptor channels, the case of ATP-gated P2X receptors

Huidobro-Toro, JP; Lorca RA; Coddou, C.

Review ISI
EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS  (2008)

43
Claudio Coddou

Profesor Asociado

Ciencias Biomédicas

Universidad Católica del Norte

Coquimbo, Chile

31
Claudio Coddou

Profesor Asociado

Departamento de Ciencias Biomédicas

Universidad Católica del Norte

Coquimbo, Chile

9
Claudio Acuña

Profesosr Asociado

Biología

UNIVERSIDAD DE SANTIAGO DE CHILE

Santiago, Chile

3
Ricardo Fernandez

Profesor Asociado A

Salud

Universidad de Los Lagos

Osorno, Chile

3
Bernardo Morales

Profesor titular

Biologia

Universidad de Santiago de Chile

Santiago, Chile

3
Erwin de la Fuente

PROFESOR/INVESTIGADOR

Ciencias Biomedicas

UNIVERSIDAD CATOLICA DEL NORTE

Coquimbo, Chile

3
Carmen Imarai

Profesor Titular

Biología

UNIVERSIDAD DE SANTIAGO DE CHILE

Santiago, Chile

2
ALEXIS ASPEE

Profesor Titular

Ciencias del Ambiente

UNIVERSIDAD DE SANTIAGO DE CHILE

Santiago, Chile

2
Rommy von Bernhardi

Full Professor

Neurology

DEPT. NEUROLOGY, FAC. MEDICINE PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

2
Jorge Escobar

PONTIFICIA UNIVERSIDAD CATÓLICA DE VALPARAÍSO

Valparaíso, Chile

2
Giuliano Bernal

Profesor Titular

Ciencias Biomédicas

UNIVERSIDAD CATÓLICA DEL NORTE

Coquimbo, Chile

2
Ricardo Fernández

Associate Professor

Salud

Universidad de Los Lagos

Osorno, Chile

2
SEBASTIAN RAMIREZ

Estudiante de Postgrado

Ciencias Biomédicas

UNIVERSIDAD CATÓLICA DEL NORTE

Coquimbo, Chile

2
Jaime Eugenin

Full Professor

Biology

Universidad de Santiago de Chile

Santiago, Chile

2
Margarita Montoya

Profesor Asociado

Biología

UNIVERSIDAD DE SANTIAGO DE CHILE, FACULTAD DE QUÍMICA Y BIOLOGÍA

Santiago, Chile

2
Eduardo Bravo

University of Iowa

Iowa City, Estados Unidos

2
Alejandro Escobar

assistant professor

Institute for Research in Dental Sciences

UNIVERSIDAD DE CHILE

Santiago, Chile

2
Kevin Maisey

Profesor Asistente

Centro de Biotecnología Acuícola

UNIVERSIDAD DE SANTIAGO DE CHILE

Santiago, Chile

2
Darwin Leiva

Assistant professor

Biology

Universidad de Santiago de Chile

Santiago, Chile

1
Antonello Penna

Profesor Asociado

Anestesiología y Medicina Perioperatoria

Universidad de Chile

Santiago, Chile

1
JAIME MELLA

PROFESOR ADJUNTO

INSTITUTO DE QUIMICA Y BIOQUIMICA

UNIVERSIDAD DE VALPARAISO

VALPARAISO, Chile

1
Mauricio Cuellar

UNIVERSIDAD DE VALPARAÍSO

Valparaíso, Chile

1
Hernan Diaz

1
Maria Godoy

Jefa de Proyectos Internacionales

Universidad Andrés Bello

Santiago, Chile

1
Jocelyn Brito

Lab manager

Instituto de Ciencias Naturales Alexander von Humboldt

Universidad de Antofagasta

Antofagasta, Chile

1
Rodrigo Sandoval

Director de departamento

Ciencias Biomédicas

UNIVERSIDAD CATOLICA DEL NORTE

Coquimbo, Chile

1
JUAN VILLENA

FULL PROFESSOR

ANATOMY

FACULTA DE MEDICINA. UNIVERSIDAD DE VALPARAISO

VIÑA DEL MAR, Chile

1
Juan Madariaga

Jefe Unidad

Hospital Coquimbo

Coquimbo, Chile

1
Miguel Reyes

Full Professor

Facultad de Ciencias Médicas

UNIVERSIDAD DE SANTIAGO DE CHILE, FACULTAD DE CIENCIAS MÉDICAS, ESCUELA DE MEDICINA

Santiago, Chile

1
Lorena Varela

Assistant Professor

Biological Sciences

Universidad Andres Bello

Santiago, Chile

1
Maria Hevia

Prosefora

Ciencias Biomedicas

Universidad Cátolica del Norte

Coquimbo, Chile

1
Victoria Espinosa

Academica titular, Vicedecana de Investigación FACIMED

Facultad de Ciencias Medicas

UNIVERSIDAD DE SANTIAGO DE CHILE

Santiago, Chile

1
Patricio Castro

profesor asistente

fisiologia

UNIVERSIDAD Concepcion

concepcion, Chile

1
Antonello Penna

Profesor Asociado

UNIVERSIDAD DE CHILE

Santiago, Chile

1
Mauricio Reyna

Asistente de Investigación

Departamento de Ciencias Biomédicas

Universidad Católica del Norte

Coquimbo, Chile

1
Gustavo Moraga

Assistant Professor

UNIVERSIDAD DE CONCEPCION

Chile

1
Gonzalo Yévenes

Associate Professor

Universidad de Concepcion

Concepcion, Chile

1
JORGE FUENTEALBA

Dean

Physiology

UNIVERISDAD DE CONCEPCION

Concepcion, Chile

1
Felipe Gordillo

UNIVERSIDAD CATÒLICA DEL MAULE

Talca, Chile

1
Luisa Bascuñán

Profesora asistente

Botánica

Universidad de Concepción

Concepción, Chile

1
Carlos Jara

Profesor adjunto

Universidad de Valparaíso

Reñaca, Chile