Man

Darwin Elias Leiva Salcedo

Assistant professor

Universidad de Santiago de Chile

Santiago, Chile

Líneas de Investigación


Synaptic integration and neuronal excitability in cortical circuits

Educación

  •  Biomedical Science, UNIVERSIDAD DE CHILE. Chile, 2009
  •  Medical Technologist, UNIVERSIDAD DE CHILE. Chile, 2002

Experiencia Académica

  •   Postdoc Full Time

    NATIONAL INSTITUTE OF HEALTH

    National Institute of Child Health and development

    Bethesda, Estados Unidos

    2009 - 2014

  •   Assistant professor Full Time

    UNIVERSIDAD DE SANTIAGO DE CHILE

    Chemistry and Biology

    Santiago, Chile

    2014 - A la fecha

Experiencia Profesional

  •   Lecturer Part Time

    Universidad Mayor

    Santiago, Chile

    2007 - 2009

Formación de Capital Humano


2016 Thesis supervisor Ms. Tania Villalon, Biochemist, title “Participación de componentes de la vía secretora en la enfermedad de Niemann-Pick tipo C”, University of Santiago
2016 Thesis supervisor Mr. Hector Valenzuela, Biochemist, Title “La interacción funcional entre el canal trpm4 (transient receptor potential melastatin-4) y el canal hcn1 (hyperpolarization-activated cyclic nucleotide-gated channel 1) regula el aumento del calcio intracelular inducido por glutamato en neuronas corticales”, University of Santiago
2016 Supervisor of Dissertation to obtain the degree of Tecnico en Análisis Quimico y Fisico, Ms. Pilar Candia “Implementación de un método de detección e identificación de los ácidos nucleicos del virus de la necrosis pancreatica infecciosa mediante electroforesis”, University of Santiago
2017 Supervisor of dissertation to obtain the degree of Tecnico en Análisis Quimico y Fisico Mr. Ignacio Lopez, ”Método analítico de Pre- transferencia Pemetrexed 25 mg/mL concentrado para solución para infusión de Analytica LAB a Synthon Chile Ltda”, University of Santiago
2017 Supervisor of dissertation to obtain the degree of Tecnico en Análisis Quimico y Fisico Mr. Camilo Osorio. ”Técnicas microbiológicas para cuantificación de coliformes totales, fecales y escherichia coli en aguas residuales y potables”, University of Santiago
2018 Supervisor of Dissertation to obtain the degree of Tecnico en Análisis Quimico y Fisico Mr. Gustavo Bustamante, “Validación de actividad bactericida de los antisépticos y desinfectantes químicos, por método de dilución neutralización según la Norma Española UNE 1040:2006”, University of Santiago
2018 Supervisor of Dissertation to obtain the degree of Tecnico en Análisis Quimico y Fisico Mr. Luis Riquelme, “Verificación de la aptitud del método de recuento microbiano y microorganismos específicos acorde a usp 40 aplicado al producto aluminio hidróxido suspensíon 6%”, University of Santiago


Premios y Distinciones

  •   NICHD Mentors of the Year category postdoc

    NATIONAL INSTITUTE OF HEALTH

    Estados Unidos, 2014

    The NICHD Mentor of the Year Award is an opportunity to recognize individuals whose mentoring has made a difference in someone’s life at NIH. The two mentoring award categories are fellows and investigators. Nominations were invited from all trainee groups in NICHD, and each nominator had to write a statement, on which the selection committee based their decisions. The selection committee included NICHD clinical and postdoctoral fellows, and postbac fellows.


 

Article (23)

EB1-and EB2-dependent anterograde trafficking of TRPM4 regulates focal adhesion turnover and cell invasion
Lithraea caustic (Litre) Extract Promotes an Antitumor Response Against B16 Melanoma
Opposing Roles of Calcium and Intracellular ATP on Gating of the Purinergic P2X2 Receptor Channel.
Subcellular Localization and Activity of TRPM4 in Medial Prefrontal Cortex Layer 2/3
Dead Tumor Cells Expressing Infectious Salmon Anemia Virus Fusogenic Protein Favor Antigen Cross-Priming In Vitro
Neuregulin-2 ablation results in dopamine dysregulation and severe behavioral phenotypes relevant to psychiatric disorders
TRPM4 activation by chemically- and oxygen deprivation-induced ischemia and reperfusion triggers neuronal death
Calcium signaling properties of a thyrotroph cell line, mouse T?T1 cells
Casein kinase-mediated phosphorylation of serine 839 is necessary for basolateral localization of the Ca2+-activated non-selective cation channel TRPM4
TRPM4 Is a Novel Component of the Adhesome Required for Focal Adhesion Disassembly, Migration and Contractility
Neuregulin Directly Decreases Voltage-Gated Sodium Current in Hippocampal ErbB4-Expressing Interneurons
The Importance of the NRG-1/ErbB4 Pathway for Synaptic Plasticity and Behaviors Associated with Psychiatric Disorders
Lipopolysaccharide Inhibits the Channel Activity of the P2X7 Receptor
Hydrogen Peroxide Removes TRPM4 Current Desensitization Conferring Increased Vulnerability to Necrotic Cell Death
P2X4 Activation Modulates Volume-sensitive Outwardly Rectifying Chloride Channels in Rat Hepatoma Cells
Activation of Cl(-) channels by human chorionic gonadotropin in luteinized granulosa cells of the human ovary modulates progesterone biosynthesis
Diminished Acute Phase Response and Increased Hepatic Inflammation of Aged Rats in Response to Intraperitoneal Injection of Lipopolysaccharide
Activation of H2O2-induced VSOR CI(-)currents in HTC cells require phospholipase C gamma 1 phosphorylation and Ca2+ mobilisation
T-kininogen induces endothelial cell proliferation
T-kininogen: A biomarker of aging in fisher 344 rats with possible implications for the immune response
T-kininogen can either induce or inhibit proliferation in Balb/c 3T3 fibroblasts, depending on the route of administration
T-kininogen, a cystatin-like molecule, inhibits ERK-dependent lymphocyte proliferation
T-kininogen inhibits kinin-mediated activation of ERK in endothelial cells

Abstract (5)

TRPM4 channels regulate migration and invasiveness of melanoma cells.
TRPM4 channels are required for biomechanical remodeling during wound healing
The Ca2+ activated non-selective cationic channel TRPM4 enhances cellular migration and contractility by modulating the focal adhesions dynamics
Protons and calcium modulate the open probability of a non selective cation channel in epithelial cells
Critical role of histidines 120, 213, 245 and 319 for the potentiation of the P2X(2) receptor by copper or zinc

Proyecto (4)

Cholinergic modulation of dendritic excitability and synaptic integration in medial prefrontal cortex layer 2/3 through CAN and H channels
Fortalecimiento de la docencia en Bioquímica Clínica, Genética y postgrado de la Facultad de Qca y Biologia
Preclinical study on the participation of pannexin 1 (Panx1) in spinal cord circuitry and its role in the mechanisms of chronic pain
ROLE OF TRPM4 CHANNEL IN THE REGULATION OF FIRING PATTERNS AND EXCITABILITY OF THE PREFRONTAL CORTEX NEURONS

Review (1)

Regulation of ATP-Gated P2X Channels: From Redox Signaling to Interactions with Other Proteins
32
Darwin Leiva

Assistant professor

Biology

Universidad de Santiago de Chile

Santiago, Chile

8
Claudio Acuña

Profesosr Asociado

Biología

UNIVERSIDAD DE SANTIAGO DE CHILE

Santiago, Chile

7
Diego Varela

Profesor Asociado

Fisiología y Biofísica

FACULTAD DE MEDICINA, UNIVERSIDAD DE CHILE

Santiago, Chile

7
Felipe Simon

Profesor Titular

Department of Biological Sciences

UNIVERSIDAD ANDRES BELLO FAC DE CS BIOLOGICAS, DPTO DE CS BIOLOGICAS

Santiago, Chile

7
Andres Stutzin

Full Professor

ICBM

FACULTAD DE MEDICINA UNIVERSIDAD DE CHILE

Santiago, Chile

7
Oscar Cerda

Associate Professor

Molecular and Cellular Biology

Universidad de Chile

Santiago, Chile

4
Alicia Colombo

Profesor Asistente/Director Científico Biobanco de Tejidos y Fluidos de la Universidad de Chile

Departamento de Anatomía Patológica

Universidad de Chile

Santiago, Chile

4
Claudio Perez

Investigador PhD Fondef

Producción Animal

Universidad de Chile

Santiago, Chile

4
Denise Riquelme

Adjunct Professor

Biology

Universidad de Santiago

Santiago, Chile

3
Monica Caceres

Profesor asistente

Instituto de ciencias biomedicas

Universidad de Chile

Santiago, Chile

3
Ricardo Armisen

Associate Professor

Centro de Genética y Genómica

Universidad del Desarrollo

Santiago, Chile

3
Pablo Olivero

Profesor Adjunto

Patologia y Fisiologia

Universidad de Valparaiso

Viña del Mar, Chile

3
Cesar Gomez

Responsible for coordinating research projects between the Department and companies, universities and research institutions.

Department of Mining and Materials Engineering, Mineral Processing Group

McGill University

Montreal, Quebec, Canada

2
Claudio Coddou

Profesor Asociado

Departamento de Ciencias Biomédicas

Universidad Católica del Norte

Coquimbo, Chile

2
Carlos Barrera

Funcionario

Biología

Universidad de Santiago de Chile

Santiago, Chile

2
Claudio Coddou

Profesor Asociado

Ciencias Biomédicas

Universidad Católica del Norte

Coquimbo, Chile

2
Ricardo Fernandez

Profesor Asociado A

Salud

Universidad de Los Lagos

Osorno, Chile

2
Ricardo Fernández

Associate Professor

Health

Universidad de Los Lagos

Osorno, Chile

2
Antonello Penna

Profesor Asociado

Anestesiología y Medicina Perioperatoria

Universidad de Chile

Santiago, Chile

2
Alejandro Escobar

assistant professor

Institute for Research in Dental Sciences

UNIVERSIDAD DE CHILE

Santiago, Chile

2
Daniela Sauma

Academic and researcher

Biologia

Universidad de Chile

Santiago, Chile

2
Carmen Imarai

Profesor Titular

Biología

UNIVERSIDAD DE SANTIAGO DE CHILE

Santiago, Chile

2
Antonello Penna

Profesor Asociado

UNIVERSIDAD DE CHILE

Santiago, Chile

2
Margarita Montoya

Profesor Asociado

Biología

UNIVERSIDAD DE SANTIAGO DE CHILE, FACULTAD DE QUÍMICA Y BIOLOGÍA

Santiago, Chile

1
Camilo Campusano

Doctorante

Genética Molecular y Microbiología

Pontificia Universidad Católica de Chile

Santiago, Chile

1
Jorge Escobar

PONTIFICIA UNIVERSIDAD CATÓLICA DE VALPARAÍSO

Valparaíso, Chile

1
Leonel Rojo

Profesor Asociado

Departamento de Biología

Universidad de Santiago de Chile

Estación Central, Chile

1
Juan Pablo Garcia Huidobro

Full Professor

Biology

Universidad de Santiago de Chile

Santiago, Chile

1
Marcelo Cortez

Académico

Biología

UNIVERSIDAD DE SANTIAGO DE CHILE

Santiago, Chile

1
Ana Riveros

Profesor Asistente

Departamento de Química Farmacológica y Toxicológica

UNIVERSIDAD DE CHILE, FACULTAD DE CIENCIAS QUIMICAS Y FARMACÉUTICAS

Santiago, Chile

1
Luigi Devoto

PROFESOR TITULAR

INSTITUTO DE INVESTIGACIONES MATERNO INFANTIL,FACULTAD DE MEDICINA, UNIVERSIDAD DE CHILE

Santiago, Chile

1
Sofía Michelson

Asistente de Investigación

Biología

Universidad de Santiago de Chile

Santiago, Chile

1
Juan García-Huidobro

Profesor Titular

Biologia

Universidad de Santiago de Chile

Santiago de Chile, Chile

1
Rocio Santander

Encargada de Laboratorio, Equipos de UHPLC-MS y GC-MS/MS

Departamento de Ciencias del Ambiente, Facultad de Química y Biología

Universidad de Santiago de Chile

Santiago, Chile

1
Ariela Vergara

Assistant Professor

Bioinformatics

UNIVERSIDAD DE TALCA

Talca, Chile