PDI - Resultado de Búsqueda

Luigi Devoto Canessa

PROFESOR TITULAR

INSTITUTO DE INVESTIGACIONES MATERNO INFANTIL,FACULTAD DE MEDICINA, UNIVERSIDAD DE CHILE

Santiago, Chile

Endocrinology and Gynecology; Reproductive Medicine - In Vitro Fertilization; Molecular endocrinology of ovary

DOCTOR EN MEDICINA, UNIVERSIDAD DE CHILE. Chile, 1971
OBSTETRICIA Y GINECOLOGIA, UNIVERSIDAD DE CHILE. Chile, 1974
Obstetrics/gynecology, UNIVERSITY OF PENNSYLVANIA. Chile, 1978

PROFESOR TITULAR Full Time

UNIVERSIDAD DE CHILE

Medicina

Santiago, Chile

2002 - A la fecha
Director Human Reproduction Division Full Time

UNIVERSIDAD DE CHILE

Medicina

Santiago, Chile

2010 - A la fecha

PROFESOR TITULAR Full Time

Universidad de Chile

Santiago, Chile

2002 - A la fecha
Director Human Reproduction Unit Full Time

Universidad de Chile

Santiago, Chile

2010 - A la fecha


Significance of pro-angiogenic estrogen metabolites in normal follicular development and follicular growth arrest in polycystic ovary syndrome Henríquez, Soledad; Kohen, Paulina; Xu, Xia; Villarroel, Claudio; Muñoz, Alex; Godoy, Ana; Strauss, Jerome F; Devoto, Luigi Article Human Reproduction (2020)
Molecular modelling predicts that 2-methoxyestradiol disrupts HIF function by binding to the PAS-B domain Poch, Andrea; Villanelo, Felipe; Henriquez, Soledad; Kohen, Paulina; Muñoz, Alex; Strauss, Jerome F.; Devoto, Luigi Article ISI SCOPUS STEROIDS (2019)
Anti-MÃ¼llerian hormone in type 2 and gestational diabetes during the second half of pregnancy=> relationship with sexual steroid levels and metabolic parameters. Villarroel, Claudio; Salinas, Abril; López, Patricia; Kohen, Paulina; Rencoret, Gustavo; Devoto, Luigi; Codner, Ethel Article Gynecological endocrinology => the official journal of the International Society of Gynecological Endocrinology (2018)
The endometria of women with endometriosis exhibit dysfunctional expression of complement regulatory proteins during the mid secretory phase. Palomino, Wilder A; Tayade, Chandrakant; Argandoña, Felipe; Devoto, Luigi; Young, Steven L; Lessey, Bruce A Article Journal of reproductive immunology (2018)
hCG activates Epac-Erk1/2 signaling regulating Progesterone Receptor expression and function in human endometrial stromal cells. Tapia-Pizarro, Alejandro; Archiles, Sebastián; Argandoña, Felipe; Valencia, Cecilia; Zavaleta, Keyla; Cecilia Johnson, M; González-Ramos, Reinaldo; Devoto, Luigi Article Molecular human reproduction (2017)
hCG activates Epac-Erk1/2 signaling regulating Progesterone Receptor expression and function in human endometrial stromal cells. Tapia-Pizarro, Alejandro; Archiles, Sebastián; Argandoña, Felipe; Valencia, Cecilia; Zavaleta, Keyla; Cecilia Johnson, M; González-Ramos, Reinaldo; Devoto, Luigi Article Molecular human reproduction (2017)
In-vitro study of gonadotrophin signaling pathways in human granulosa cells in relation to progesterone receptor expression. Henríquez S, Kohen P; Muñoz A, Godoy A; Orge F, Strauss JF 3rd Article REPRODUCTIVE BIOMEDICINE ONLINE (2017)
Pregestational type 2 diabetes and gestational diabetes exhibit different sexual steroid profiles during pregnancy. Villarroel, Claudio; Salinas, Abril; López, Patricia; Kohen, Paulina; Rencoret, Gustavo; Devoto, Luigi; Codner, Ethel Article Gynecological endocrinology => the official journal of the International Society of Gynecological Endocrinology (2017)
The significance of estradiol metabolites in human corpus luteum physiology. Devoto, Luigi; Henríquez, Soledad; Kohen, Paulina; Strauss, Jerome F Article Steroids (2017)
The significance of estradiol metabolites in human corpus luteum physiology. Devoto L, Henríquez S; Kohen P, Strauss JF 3rd. Article STEROIDS (2017)
Endometrial expression and inÂ vitro modulation of the iron transporter divalent metal transporter-1=> implications for endometriosis. Alvarado-Díaz, Carlos Patricio; Núñez, Marco Tulio; Devoto, Luigi; González-Ramos, Reinaldo Article Fertility and sterility (2016)
Estrogen metabolites in human corpus luteum physiology=> differential effects on angiogenic activity. Henríquez, Soledad; Kohen, Paulina; Xu, Xia; Veenstra, Timothy D; Muñoz, Alex; Palomino, Wilder A; Strauss, Jerome F; Devoto, Luigi Article Fertility and sterility (2016)
Estrogen metabolites in human corpus luteum physiology=> differential effects on angiogenic activity. Henríquez S, Kohen P; Xu X, Veenstra TD; Muñoz A, Palomino WA; Strauss JF 3rd, Devoto L. Article FERTILITY AND STERILITY (2016)
Progesterone: From ovulation to pregnancy Devoto L. Article SCOPUS Giornale Italiano di Ostetricia e Ginecologia (2016)
Iron overload-modulated nuclear factor kappa-B activation in human endometrial stromal cells as a mechanism postulated in endometriosis pathogenesis Alvarado-Diaz C.P.; Núñez M.T.; Devoto L.; Gonzalez-Ramos, R Article ISI SCOPUS FERTILITY AND STERILITY (2015)
2-Methoxyestradiol in the human corpus luteum throughout the luteal phase and its influence on lutein cell steroidogenesis and angiogenic activity Kohen P.; Henríquez S.; Rojas C.; Gerk, PM; Palomino, WA; Strauss, JF; Devoto L. Article ISI SCOPUS Fertility and Sterility (2013)
Complement C3 and Decay-Accelerating Factor Expression Levels Are Modulated by Human Chorionic Gonadotropin in Endometrial Compartments During the Implantation Window Palomino, WA; Argandona, F; Azua, R; Kohen P.; Devoto L. Article ISI SCOPUS Reproductive Sciences (2013)
Human chorionic gonadotropin (hCG) modulation of TIMP1 secretion by human endometrial stromal cells facilitates extravillous trophoblast invasion in vitro Tapia-Pizarro, A; Argandona, F; Palomino, WA; Devoto L. Article ISI SCOPUS Human Reproduction (2013)
Silencing of tumor suppressor genes RASSF1A, SLIT2, and WIF1 by promoter hypermethylation in hereditary breast cancer Alvarez C.; Tapia, T.; Cornejo, V; Fernandez, W; MuÑoz A.; Camus, M; Alvarez M.; Devoto L.; Carvallo, P. Article ISI SCOPUS Molecular Carcinogenesis (2013)
Nuclear factor-kappaB: a main regulator of inflammation and cell survival in endometriosis pathophysiology Gonzalez-Ramos, R; Defrere, S; Devoto L. Article ISI SCOPUS Fertility and Sterility (2012)
Physiologic activation of nuclear factor kappa-B in the endometrium during the menstrual cycle is altered in endometriosis patients Gonzalez-Ramos, R; Rocco J.; Rojas C.; Sovino H.; Poch, A; Kohen P.; Alvarado-Diaz C.; Devoto L. Article ISI SCOPUS Fertility and Sterility (2012)
Transient expression of progesterone receptor and cathepsin-l in human granulosa cells during the periovulatory period garcia, v; Kohen P.; Maldonado, C; Sierralta W.; MuÑoz A.; villarroel, c; Strauss J.F.; Devoto L. Article ISI SCOPUS Fertility and Sterility (2012)
Bioinformatic detection of E47, E2F1 and SREBP1 transcription factors as potential regulators of genes associated to acquisition of endometrial receptivity Tapia, A; Devoto L.; Vilos C.; Croxatto H.B.; Marín J.C. Article ISI SCOPUS Reproductive Biology and Endocrinology (2011)
A single midcycle dose of levonorgestrel similar to emergency contraceptive does not alter the expression of the L-selectin ligand or molecular markers of endometrial receptivity Palomino, WA; Kohen P.; Devoto L. Article ISI SCOPUS Fertility and Sterility (2010)
Assessment of diagnostic competence of plasmatic androgens on polycystic ovary syndrome based on receiver operator characteristic curves villarroel, c; Trejo, L; MuÑoz A.; Kohen P.; Fuentes, A.; Devoto L. Article ISI SCOPUS Gynecological Endocrinology (2010)
Association between motherhood postponement and socioeconomic status Fuentes, A.; Jesam C.; Devoto L.; Angarita B.; Galleguillos A.; Torres A.; MacKenna A. Article ISI REVISTA MEDICA DE CHILE (2010)
Association between motherhood postponement and socioeconomic status [Postergación de la maternidad en chile: Una realidad oculta] Fuentes A.; Jesam C.; Devoto L.; Angarita B.; Galleguillos A.; Torres A.; MacKenna A. Article SCOPUS Revista Medica de Chile (2010)
Involvement of the nuclear factor-kappa B pathway in the pathogenesis of endometriosis Gonzalez-Ramos, R; Van Langendonckt A.; Defrere, S; Lousse, JC; Colette S.; Devoto L.; Donnez J. Article ISI SCOPUS Fertility and Sterility (2010)
Men's participation in psychologic counseling services offered during in vitro fertilization treatments Furman I.; Parra, L; Fuentes, A.; Devoto L. Article ISI SCOPUS Fertility and Sterility (2010)
Postergación de la maternidad en Chile: Una realidad oculta Fuentes, Ariel; JESAM, CRISTIAN; Devoto, Luigi; ANGARITA, BLANCA; GALLEGUILLOS, ANDREA; Torres, Andrea; Mackenna, Antonio Article SCIELO REVISTA MEDICA DE CHILE (2010)
Human corpus luteum physiology and the luteal-phase dysfunction associated with ovarian stimulation Devoto L.; Kohen P.; MuÑoz A.; Strauss, JF Article ISI SCOPUS REPRODUCTIVE BIOMEDICINE ONLINE (2009)
Activation of Cl(-) channels by human chorionic gonadotropin in luteinized granulosa cells of the human ovary modulates progesterone biosynthesis Olivero P.; Leiva-Salcedo, E; Devoto L.; Stutzin A. Article ISI SCOPUS ENDOCRINOLOGY (2008)
Promoter hypermethylation of BRCA1 correlates with absence of expression in hereditary breast cancer tumors Tapia, T.; Smalley SV; Kohen P.; MuÑoz A.; Solis, LM; Corvalan, A; Faundez, P; Devoto L.; Camus, M; Alvarez M.; Carvallo, P. Article ISI SCOPUS EPIGENETICS (2008)
Features of natural and gonadotropin-releasing hormone antagonist-induced corpus luteum regression and effects of in vivo human chorionic gonadotropin Del Canto, F; Sierralta W.; Kohen P.; MuÑoz A.; Strauss, JF; Devoto L. Article ISI SCOPUS JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2007)
Tumor necrosis factor-alpha activates nuclear factor-kappa B but does not regulate progesterone production in cultured human granulosa luteal cells Gonzalez-Navarrete, F; Eisner V.; Morales P.; Castro O.; Pommer R.; Quiroga, C; Lavandero S.; Devoto L. Article ISI SCOPUS GYNECOLOGICAL ENDOCRINOLOGY (2007)
Differential expression of endometrial integrins and progesterone receptor during the window of implantation in normo-ovulatory women treated with clorniphene citrate Palomino, WA; Fuentes, A.; González RR; Gabler F.; Boric, MA; Vega M.; Devoto L. Article ISI SCOPUS FERTILITY AND STERILITY (2005)
Pharmacokinetics and endometrial tissue levels of levonorgestrel after administration of a single 1.5-mg dose by the oral and vaginal route Devoto L.; Fuentes, A.; Palomino A.; Espinoza, A.; Kohen P.; Ranta, S; von Hertzen, H Article ISI SCOPUS FERTILITY AND STERILITY (2005)
Ultrastructural and biochemical evidence for the presence of mature steroidogenic acute regulatory protein (StAR) in the cytoplasm of human luteal cells Sierralta WD; Kohen P.; Castro O.; MuÑoz A.; Strauss, JF; Devoto L. Article ISI SCOPUS MOLECULAR AND CELLULAR ENDOCRINOLOGY (2005)
The steroidogenic response and corpus luteum expression of the steroidogenic acute regulatory protein after human chorionic gonadotropin administration at different times in the human luteal phase Kohen P.; Castro O.; Palomino A.; MuÑoz A.; Christenson, LK; Sierralta W.; Carvallo, P.; Strauss, JF; Devoto L. Article ISI SCOPUS JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2003)
Control of human luteal steroidogenesis Devoto L.; Kohen P.; Vega M.; Castro O.; González RR; Retamales, I; Carvallo, P.; Christenson, LK; Strauss, JF Article ISI MOLECULAR AND CELLULAR ENDOCRINOLOGY (2002)
Molecular regulation of progesterone secretion by the human corpus luteum throughout the menstrual cycle Devoto L.; Vega M.; Kohen P.; Castro O.; Carvallo, P.; Palomino A. Article ISI JOURNAL OF REPRODUCTIVE IMMUNOLOGY (2002)
Effects of leptin, interleukin-1 alpha, interieukin-6, and transforming growth factor-beta on markers of trophoblast invasive phenotype González RR; Devoto L.; Campana, A; Bischof, P Article ISI ENDOCRINE (2001)
Expression of steroidogenic acute regulatory protein in the human corpus luteum throughout the luteal phase Devoto L.; Kohen P.; González RR; Castro O.; Retamales, I; Vega M.; Carvallo, P.; Chrisenson, LK; Strauss, JF Article ISI SCOPUS JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2001)
Resumption of ovarian function during lactational amenorrhoea in breastfeeding women with polycystic ovarian syndrome: endocrine aspects Sir Petermann T; Devoto L.; Maliqueo, M; Peirano P.; Recabarren SE; Wildt L. Article ISI SCOPUS HUMAN REPRODUCTION (2001)
Endocrine and paracrine-autocrine regulation of the human corpus luteum during the mid-luteal phase Devoto L.; Vega M.; Kohen P.; Castro A.; Castro O.; Christenson, LK; Carvallo, P.; Strauss, JF Article ISI JOURNAL OF REPRODUCTION AND FERTILITY (2000)
Leptin and leptin receptor are expressed in the human endometrium and endometrial leptin secretion is regulated by the human blastocyst González RR; Caballero-Campo, P; Jasper, M; Mercader, A; Devoto L.; Pellicer, A; Simon C. Article ISI SCOPUS JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2000)
Nitric oxide induces apoptosis in the human corpus luteum in vitro Vega M.; Urrutia L.; Iñiguez G.; Gabler F.; Devoto L.; Johnson, MC Article ISI SCOPUS MOLECULAR HUMAN REPRODUCTION (2000)


EUTOPIC ENDOMETRIUM FROM WOMEN WITH ENDOMETRIOSIS EXHIBITS DECREASED LEVELS OF COMPLEMENT DECAY- ACCELERATING FACTOR AND ABNORMAL EXPRESSION OF PROGESTERONE RECEPTOR DURING THE IMPLANTATION WINDOW Palomino, WA; Aguilar S.; Ortiz, M; Argandona, FA; Kohen P.; Devoto L. Abstract ISI PLACENTA (2015)
Signal transduction pathways activated by human chorionic gonadotropin (hCG) in human endometrial stromal cells (ESC) Tapia-Pizarro, A; Archiles, S; Argandona, F; Devoto L. Abstract ISI HUMAN REPRODUCTION (2013)
Transvaginal ultrasound for diagnosis of deeply infiltrating endometriosis Scarella A.; Chamy v; Devoto L.; Abrao, M; Sovino H. Abstract ISI HUMAN REPRODUCTION (2013)
Glucotransporters (GLUTs) expression and function in human endometrium from normal and Polycystic Ovary Syndrome women (PCOS): Effect of long term metformin (M) treatment Pustovrh C.; villarroel, c; Arriagada C.; MuÑoz A.; Kohen P.; Nestler, JE; Devoto L. Abstract ISI HUMAN REPRODUCTION (2012)
Human chorionic gonadotrophin (hCG) signaling in endometrial stromal cells modulates extracelular matrix (ECM) remodeling and increases trophoblast invasion in vitro Tapia-Pizarro, A; Argandona, F; Archiles, S; Devoto L. Abstract ISI HUMAN REPRODUCTION (2012)
The endometrial expression of complement C3 is modulated by human chorionic gonadotropin during the implantation window Palomino, WA; Argandona, F; Kohen P.; Azua, R; Scarella A.; Devoto L. Abstract ISI HUMAN REPRODUCTION (2011)
NF-kappaB-p65 and -RelB expression and activation in endometrium from endometriosis patients and healthy women throughout the menstrual cycle Gonzalez-Ramos, R; Rojas C.; Rocco J.; Poch, A; Sovino H.; Kohen P.; MuÑoz A.; Devoto L. Abstract ISI HUMAN REPRODUCTION (2010)
THE alpha nu beta 3 INTEGRIN ASSOCIATES WITH COMPLEMENT REGULATORY PROTEIN DECAY ACCELERATING FACTOR (DAF/CD55) AND OSTEOPONTIN (OPN) IN ENDOMETRIAL CELLS DURING THE WINDOW OF IMPLANTATION. Palomino, WA; Young, SL; Barros D.; Kohen P.; Devoto L.; Lessey, BA Abstract ISI FERTILITY AND STERILITY (2010)
Modulating effect of chloride efflux on hCG-induced progesterone release in primary cultures of human granulosa cells Olivero P.; Castro O.; Devoto L.; Stutzin A. Abstract ISI PLACENTA (2006)


Outcome of in vitro fertilization in patients with advanced endometriosis; Role of endometrioma Diaz, E.; Pommer R.; Sovino H.; Cespedes P; Fuentes, A.; Arguello, B; Espinoza, A.; Devoto L. ConferencePaper ISI PROCEEDINGS OF THE 14TH WORLD CONGRESS ON IN VITRO FERTILIZATION & 3RD WORLD CONGRESS ON IN VITRO MATURATION (2007)
Differential steroidogenic effect of pituitary hormones in primate corpus luteum Devoto L.; Kohen P.; Castro O.; Palomino A.; Vega M. ConferencePaper ISI ADVANCES IN GYNECOLOGICAL ENDOCRINOLOGY (2002)


Link between metformin and the peroxisome proliferator-activated receptor gamma pathway in the uterine tissue of hyperandrogenized prepubertal mice Elia, EM; Pustovrh C.; Amalfi S.; Devoto L.; Motta, AB EditorialMaterial ISI SCOPUS Fertility and Sterility (2011)
Endometrial progesterone receptors and levonorgestrel as emergency contraceptive Palomino, WA; Devoto L. EditorialMaterial ISI SCOPUS Gynecological Endocrinology (2010)
Luteal phase physiology and its relevance for steroids and human chorionic gonadotropin treatment Devoto L. EditorialMaterial ISI GYNECOLOGICAL ENDOCRINOLOGY (2008)
Pharmacokinetics of a single oral dose of 1.5-mg levonorgestrel when administered as 750-mu g tablets or as 30-mu g minipills Devoto L.; Espinoza, A.; MuÑoz A.; Fuentes, A.; von Hertzen, H EditorialMaterial ISI SCOPUS FERTILITY AND STERILITY (2007)


ASSESSMENT OF COMPLEMENT SYSTEM PROTEINS IN RESPONSE YO HUMAN CHORIONIC GONADOTROPIN IN NORMAL ENDOMETRIUM FROM FERTILE WOMAN AND ABNORMAL ENDOMETRIUM FROM WOMEN WITH ENDOMETRIOSIS AND FROM CONTROLLED OVARIAN STIMULATED CYCLES FOR IN VITRO FE FONDECYT (1140688) Proyecto 2014-2017 Coinvestigador(a)
ESTROGEN METABOLITES AND ITS SIGNIFICANCE IN HUMAN OVARIAN PHYSIOLOGY AND PATHOPHYSIOLOGY. CLINICAL IMPLICATION IN POLYCYSTIC OVARIAN SYNDROME. FONDECYT (1140693) Proyecto 2014-2017 Inv. Responsable
EFECTO DE PROGESTERONA Y SU RECEPTOR SOBRE LA EXPRESION DE PROTEASAS INVOLUCRADAS EN LA DEGRADACION DE LA MATRIZ EXTRACELULAR OVARICA DURANTE EL PERIODO PERIOVULATORIO. FONDECYT (3130551) Proyecto 2012-2015 Inv. Patrocinante
ASSESSMENT AND HANDLING OF LASER MICRODISSECTION FOR FUNCTIONAL EVALUATION OF THE EFFECT OF HUMAN CHORIONIC GONADOTROPIN ON ENDOMETRIUM FROM NORMAL FERTILE WOMEN FONDECYT (1100217) Proyecto 2010-2012 Coinvestigador(a)
Search, isolation and characterization of adult stem cells in miomas”. Project University of Valencia, Spain (C. Simón, MD), University of Chile, Chile (L. Devoto, MD). Agencia Iberoamericana de Cooperación Internacional (AICI-A/018463-08) Proyecto 2009-2010 Inv. Principal
VALIDATION OF ENDOMETRIAL MARKERS WITH PREDICTIVE VALUE FOR EMBRYO IMPLANTATION FAILURE FONDECYT (3090075) Proyecto 2008-2010 Inv. Patrocinante
AS900672-Enriched in ovulation induction Merck-SERONO, Chile (Serono-27818) Proyecto 2007-2010 Inv. Principal
Phase III non-controlled study to determine the non-immunogenic properties and safety of ORG-36286 in patients undergoing repeated cycles of controlled ovarian hyperstimulation using multiple doses of GnRH antagonist AKZO-Nobel, Organon, Chile (Protocolo Trust 38825) Proyecto 2007-2009 Inv. Principal
“Research training program in reproductive biology and medicine for latin american scientists”. Fogarty-NIH. Virginia Commonwealth University, USA -University of Chile, Chile. (RFA-TW-05-002) Proyecto 2006-2011 Inv. Principal
MODULADORES INTRALUTEOS DE LA BIOSINTESIS DE PROGESTERONA=> ROL EN LA LUTEOLISIS Y EN EL RESCATE DE LA FUNCION LUTEA EN MUJERES NORMALES Y CON ENDOMETRIOSIS FONDECYT (1020092) Proyecto 2002-2003 Inv. Responsable
“Signalling transduction in the cells”. Signalling transduction in ovarian steroidogenesis FONDAP (15010003.) Proyecto 2002-2012 Inv. Principal
ROL DE LA PROTEINA REGULADORA DE LA ESTEROIDOGENESIS AGUDA "STAR", EN LA FISIOLOGIA DEL CUERPO LUTEO Y EN LA ANOVULACION CRONICA. FONDECYT (1990042) Proyecto 1999-2002 Inv. Responsable


Neuroendocrinology and ovarian aging Devoto L.; Palomino A.; Cespedes P; Kohen P. Review ISI SCOPUS Gynecological Endocrinology (2012)
The human corpus luteum: life cycle and function in natural cycles Devoto L.; Fuentes, A.; Kohen P.; Cespedes P; Palomino A.; Pommer R.; MuÑoz A.; Strauss, JF Review ISI SCOPUS FERTILITY AND STERILITY (2009)
Implantation of the human embryo: Research lines and models Bischof, P; Aplin, JD; Bentin-Ley, U; Brannstrom, M; Casslen, B; Castrillo, JL; Classen-Linke, I; Critchley, HOD; Devoto L.; D'Hooghe, T; Horcajadas, JA; Groothuis, P; Ivell, R; Pongrantz, I; Macklon, NS; Sharkey, A; Vicovac, L; White, JO; Winterhager, E; Von Wolff M.; Simon C.; Stavreus-Evers, A Review ISI GYNECOLOGIC AND OBSTETRIC INVESTIGATION (2006)
Mechanism of action of hormonal preparations used for emergency contraception: a review of the literature Croxatto HB; Devoto L.; Durand M.; Ezcurra, E.; Larrea, F; Nagle, C; Ortiz ME; Vantman D; Vega M.; von Hertzen, H Review ISI CONTRACEPTION (2001)
Leptin and reproduction González RR; Simon C.; Caballero-Campo, P; Norman, RJ; Chardonnens, D; Devoto L.; Bischof, P Review ISI HUMAN REPRODUCTION UPDATE (2000)