Man

Luigi Devoto Canessa

PROFESOR TITULAR

INSTITUTO DE INVESTIGACIONES MATERNO INFANTIL,FACULTAD DE MEDICINA, UNIVERSIDAD DE CHILE

Santiago, Chile

Líneas de Investigación


Endocrinology and Gynecology; Reproductive Medicine - In Vitro Fertilization; Molecular endocrinology of ovary

Educación

  •  DOCTOR EN MEDICINA, UNIVERSIDAD DE CHILE. Chile, 1971
  •  OBSTETRICIA Y GINECOLOGIA, UNIVERSIDAD DE CHILE. Chile, 1974
  •  Obstetrics/gynecology, UNIVERSITY OF PENNSYLVANIA. Chile, 1978

Experiencia Académica

  •   PROFESOR TITULAR Full Time

    UNIVERSIDAD DE CHILE

    Medicina

    Santiago, Chile

    2002 - A la fecha

  •   Director Human Reproduction Division Full Time

    UNIVERSIDAD DE CHILE

    Medicina

    Santiago, Chile

    2010 - A la fecha

Experiencia Profesional

  •   PROFESOR TITULAR Full Time

    Universidad de Chile

    Santiago, Chile

    2002 - A la fecha

  •   Director Human Reproduction Unit Full Time

    Universidad de Chile

    Santiago, Chile

    2010 - A la fecha


 

Article (47)

Significance of pro-angiogenic estrogen metabolites in normal follicular development and follicular growth arrest in polycystic ovary syndrome
Molecular modelling predicts that 2-methoxyestradiol disrupts HIF function by binding to the PAS-B domain
Anti-Müllerian hormone in type 2 and gestational diabetes during the second half of pregnancy=> relationship with sexual steroid levels and metabolic parameters.
The endometria of women with endometriosis exhibit dysfunctional expression of complement regulatory proteins during the mid secretory phase.
hCG activates Epac-Erk1/2 signaling regulating Progesterone Receptor expression and function in human endometrial stromal cells.
hCG activates Epac-Erk1/2 signaling regulating Progesterone Receptor expression and function in human endometrial stromal cells.
In-vitro study of gonadotrophin signaling pathways in human granulosa cells in relation to progesterone receptor expression.
Pregestational type 2 diabetes and gestational diabetes exhibit different sexual steroid profiles during pregnancy.
The significance of estradiol metabolites in human corpus luteum physiology.
The significance of estradiol metabolites in human corpus luteum physiology.
Endometrial expression and in vitro modulation of the iron transporter divalent metal transporter-1=> implications for endometriosis.
Estrogen metabolites in human corpus luteum physiology=> differential effects on angiogenic activity.
Estrogen metabolites in human corpus luteum physiology=> differential effects on angiogenic activity.
Progesterone: From ovulation to pregnancy
Iron overload-modulated nuclear factor kappa-B activation in human endometrial stromal cells as a mechanism postulated in endometriosis pathogenesis
2-Methoxyestradiol in the human corpus luteum throughout the luteal phase and its influence on lutein cell steroidogenesis and angiogenic activity
Complement C3 and Decay-Accelerating Factor Expression Levels Are Modulated by Human Chorionic Gonadotropin in Endometrial Compartments During the Implantation Window
Human chorionic gonadotropin (hCG) modulation of TIMP1 secretion by human endometrial stromal cells facilitates extravillous trophoblast invasion in vitro
Silencing of tumor suppressor genes RASSF1A, SLIT2, and WIF1 by promoter hypermethylation in hereditary breast cancer
Nuclear factor-kappaB: a main regulator of inflammation and cell survival in endometriosis pathophysiology
Physiologic activation of nuclear factor kappa-B in the endometrium during the menstrual cycle is altered in endometriosis patients
Transient expression of progesterone receptor and cathepsin-l in human granulosa cells during the periovulatory period
Bioinformatic detection of E47, E2F1 and SREBP1 transcription factors as potential regulators of genes associated to acquisition of endometrial receptivity
A single midcycle dose of levonorgestrel similar to emergency contraceptive does not alter the expression of the L-selectin ligand or molecular markers of endometrial receptivity
Assessment of diagnostic competence of plasmatic androgens on polycystic ovary syndrome based on receiver operator characteristic curves
Association between motherhood postponement and socioeconomic status
Association between motherhood postponement and socioeconomic status [Postergación de la maternidad en chile: Una realidad oculta]
Involvement of the nuclear factor-kappa B pathway in the pathogenesis of endometriosis
Men's participation in psychologic counseling services offered during in vitro fertilization treatments
Postergación de la maternidad en Chile: Una realidad oculta
Human corpus luteum physiology and the luteal-phase dysfunction associated with ovarian stimulation
Activation of Cl(-) channels by human chorionic gonadotropin in luteinized granulosa cells of the human ovary modulates progesterone biosynthesis
Promoter hypermethylation of BRCA1 correlates with absence of expression in hereditary breast cancer tumors
Features of natural and gonadotropin-releasing hormone antagonist-induced corpus luteum regression and effects of in vivo human chorionic gonadotropin
Tumor necrosis factor-alpha activates nuclear factor-kappa B but does not regulate progesterone production in cultured human granulosa luteal cells
Differential expression of endometrial integrins and progesterone receptor during the window of implantation in normo-ovulatory women treated with clorniphene citrate
Pharmacokinetics and endometrial tissue levels of levonorgestrel after administration of a single 1.5-mg dose by the oral and vaginal route
Ultrastructural and biochemical evidence for the presence of mature steroidogenic acute regulatory protein (StAR) in the cytoplasm of human luteal cells
The steroidogenic response and corpus luteum expression of the steroidogenic acute regulatory protein after human chorionic gonadotropin administration at different times in the human luteal phase
Control of human luteal steroidogenesis
Molecular regulation of progesterone secretion by the human corpus luteum throughout the menstrual cycle
Effects of leptin, interleukin-1 alpha, interieukin-6, and transforming growth factor-beta on markers of trophoblast invasive phenotype
Expression of steroidogenic acute regulatory protein in the human corpus luteum throughout the luteal phase
Resumption of ovarian function during lactational amenorrhoea in breastfeeding women with polycystic ovarian syndrome: endocrine aspects
Endocrine and paracrine-autocrine regulation of the human corpus luteum during the mid-luteal phase
Leptin and leptin receptor are expressed in the human endometrium and endometrial leptin secretion is regulated by the human blastocyst
Nitric oxide induces apoptosis in the human corpus luteum in vitro

Abstract (9)

EUTOPIC ENDOMETRIUM FROM WOMEN WITH ENDOMETRIOSIS EXHIBITS DECREASED LEVELS OF COMPLEMENT DECAY- ACCELERATING FACTOR AND ABNORMAL EXPRESSION OF PROGESTERONE RECEPTOR DURING THE IMPLANTATION WINDOW
Signal transduction pathways activated by human chorionic gonadotropin (hCG) in human endometrial stromal cells (ESC)
Transvaginal ultrasound for diagnosis of deeply infiltrating endometriosis
Glucotransporters (GLUTs) expression and function in human endometrium from normal and Polycystic Ovary Syndrome women (PCOS): Effect of long term metformin (M) treatment
Human chorionic gonadotrophin (hCG) signaling in endometrial stromal cells modulates extracelular matrix (ECM) remodeling and increases trophoblast invasion in vitro
The endometrial expression of complement C3 is modulated by human chorionic gonadotropin during the implantation window
NF-kappaB-p65 and -RelB expression and activation in endometrium from endometriosis patients and healthy women throughout the menstrual cycle
THE alpha nu beta 3 INTEGRIN ASSOCIATES WITH COMPLEMENT REGULATORY PROTEIN DECAY ACCELERATING FACTOR (DAF/CD55) AND OSTEOPONTIN (OPN) IN ENDOMETRIAL CELLS DURING THE WINDOW OF IMPLANTATION.
Modulating effect of chloride efflux on hCG-induced progesterone release in primary cultures of human granulosa cells

ConferencePaper (2)

Outcome of in vitro fertilization in patients with advanced endometriosis; Role of endometrioma
Differential steroidogenic effect of pituitary hormones in primate corpus luteum

EditorialMaterial (4)

Link between metformin and the peroxisome proliferator-activated receptor gamma pathway in the uterine tissue of hyperandrogenized prepubertal mice
Endometrial progesterone receptors and levonorgestrel as emergency contraceptive
Luteal phase physiology and its relevance for steroids and human chorionic gonadotropin treatment
Pharmacokinetics of a single oral dose of 1.5-mg levonorgestrel when administered as 750-mu g tablets or as 30-mu g minipills

Proyecto (12)

ASSESSMENT OF COMPLEMENT SYSTEM PROTEINS IN RESPONSE YO HUMAN CHORIONIC GONADOTROPIN IN NORMAL ENDOMETRIUM FROM FERTILE WOMAN AND ABNORMAL ENDOMETRIUM FROM WOMEN WITH ENDOMETRIOSIS AND FROM CONTROLLED OVARIAN STIMULATED CYCLES FOR IN VITRO FE
ESTROGEN METABOLITES AND ITS SIGNIFICANCE IN HUMAN OVARIAN PHYSIOLOGY AND PATHOPHYSIOLOGY. CLINICAL IMPLICATION IN POLYCYSTIC OVARIAN SYNDROME.
EFECTO DE PROGESTERONA Y SU RECEPTOR SOBRE LA EXPRESION DE PROTEASAS INVOLUCRADAS EN LA DEGRADACION DE LA MATRIZ EXTRACELULAR OVARICA DURANTE EL PERIODO PERIOVULATORIO.
ASSESSMENT AND HANDLING OF LASER MICRODISSECTION FOR FUNCTIONAL EVALUATION OF THE EFFECT OF HUMAN CHORIONIC GONADOTROPIN ON ENDOMETRIUM FROM NORMAL FERTILE WOMEN
Search, isolation and characterization of adult stem cells in miomas”. Project University of Valencia, Spain (C. Simón, MD), University of Chile, Chile (L. Devoto, MD).
VALIDATION OF ENDOMETRIAL MARKERS WITH PREDICTIVE VALUE FOR EMBRYO IMPLANTATION FAILURE
AS900672-Enriched in ovulation induction
Phase III non-controlled study to determine the non-immunogenic properties and safety of ORG-36286 in patients undergoing repeated cycles of controlled ovarian hyperstimulation using multiple doses of GnRH antagonist
“Research training program in reproductive biology and medicine for latin american scientists”.
MODULADORES INTRALUTEOS DE LA BIOSINTESIS DE PROGESTERONA=> ROL EN LA LUTEOLISIS Y EN EL RESCATE DE LA FUNCION LUTEA EN MUJERES NORMALES Y CON ENDOMETRIOSIS
“Signalling transduction in the cells”. Signalling transduction in ovarian steroidogenesis
ROL DE LA PROTEINA REGULADORA DE LA ESTEROIDOGENESIS AGUDA "STAR", EN LA FISIOLOGIA DEL CUERPO LUTEO Y EN LA ANOVULACION CRONICA.

Review (5)

Neuroendocrinology and ovarian aging
The human corpus luteum: life cycle and function in natural cycles
Implantation of the human embryo: Research lines and models
Mechanism of action of hormonal preparations used for emergency contraception: a review of the literature
Leptin and reproduction
56
Luigi Devoto

PROFESOR TITULAR

INSTITUTO DE INVESTIGACIONES MATERNO INFANTIL,FACULTAD DE MEDICINA, UNIVERSIDAD DE CHILE

Santiago, Chile

12
Alvaro Muñoz

UNIVERSIDAD ANDRES BELLO

Santiago, Chile

8
Maria Vega

Academico Profesora Titular

Obstetricia y Ginecologia Campus Norte

UNIVERSIDAD DE CHILE - FACULTAD DE MEDICINA

Santiago, Chile

3
Claudio Villarroel

Sub-Director

INSTITUTO DE INVESTIGACIONES MATERNO INFANTIL (IDIMI)

Santiago, Chile

3
Pablo Céspedes

Director Programa Fertilizacion Asistida

IDIMI

Santiago, Chile

2
Pablo Olivero

Profesor Adjunto

Patologia y Fisiologia

Universidad de Valparaiso

Viña del Mar, Chile

2
Alejandro Tapia

Profesor Asistente

Facultad de Medicina

Universidad de Chile

Santiago, Chile

2
ALEJANDRO CORVALAN

Associate Professor

Hematology and Oncology

Pontificia Universidad Catolica de Chile

Santiago, Chile

2
Soledad Henriquez

Profesor Asistente

INSTITUTO DE INVESTIGACIONES MATERNO INFANTIL, FACULTAD DE MEDICINA, UNIVERSIDAD DE CHILE

Santiago, Chile

1
Frans Fuentes

STAFF

PROGRAMA DE REPRODUCCIÓN

IDIMI-FACULTAD DE MEDICINA-UNIVERSIDAD DE CHILE

Santiago, Chile

1
Darwin Leiva

Assistant professor

Biology

Universidad de Santiago de Chile

Santiago, Chile

1
Juan Marín

Profesor Asociado

Departamento de Ciencias Básicas

Universidad del Bio Bio

Chillán, Chile

1
Carolina Alvarez

Profesor Asociado Planta Especial Docente

PONTIFICIA UNIVERSIDAD CATÓLICA CHILE

Santiago, Chile

1
Marco Nuñez

Professor

Biology

Fac. Ciencias, Universidad de Chile

Santiago, Chile

1
Andres Stutzin

Full Professor

ICBM

FACULTAD DE MEDICINA UNIVERSIDAD DE CHILE

Santiago, Chile

1
Sergio Lavandero

Director

Advanced Center for Chronic Diseases (ACCDiS)

UNIVERSIDAD DE CHILE, FAC CIENCIAS QUÍMICAS Y FARMACÉUTICAS

Santiago, Chile

1
Clara Quiroga

Profesor Asistente Adjunto

División de Enfermedades Cardiovasculares

Pontificia Universidad Católica de Chile

Santiago, Chile

1
Felipe Del Canto

Profesor Asistente

Programa de Microbiologia y Micologia

FACULTAD DE MEDICINA, UNIVERSIDAD DE CHILE

SANTIAGO, Chile

1
Cristian Vilos

Profesor Jornada Completa

Medicina

Universidad de Talca

Talca, Chile

1
Veronica Eisner

Associate Professor

Cellular and Molecular Biology

Pontificia Universidad Católica de Chile

Santiago, Chile