Man

Germán Francisco Iñiguez Vila

INSTITUTO DE INVESTIGACIONES MATERNO INFANTIL, FACULTAD DE MEDICINA, UNIVERSIDAD DE CHILE

Santiago, Chile

Líneas de Investigación


Perinatal Conditioning of Adult Diseases. A Role for the Endocannabinoid System. Neonatal Programming; Endocannabinoid/Cannabinoid Receptors-Mediated Cellular Events. Function in Different Tissues.; Nutrition-Pollution Interactions. Toxic elements in Placentas and Health Consequences in the Offspring; EFECTO DE ACIDO FOLICO EN LA SALUD; NUTRICION Y ENVEJECIMIENTO; NUTRICION Y DAÑO HEPATICO; Fetal programming; Nutrition-pollution interaction; Endocrine disruptors; Eje somatotrófico placentario; Alteraciones en crecimiento pre y postnatal; Pubertad


 

Article (85)

Klotho Gene and Protein in Human Placentas According to Birth Weight and Gestational Age.
Patterns of Infancy Growth and Metabolic Hormonal Profile Are Different in Very-Low-Birth-Weight Preterm Infants Born Small for Gestational Age Compared to Those Born Appropriate for Gestational Age.
High DHEAS Is Associated With Earlier Pubertal Events in Girls But Not in Boys.
Hyperandrogenism in adolescent girls=> relationship with the somatotrophic axis.
Hyperandrogenism in adolescent girls=> relationship with the somatotrophic axis.
Long-term metabolic risk among children born premature or small for gestational age.
C-Reactive protein and insulin growth factor1 serum levels during the menstrual cycle in adolescents with Type 1 diabetes
Relationship between folate transporters expression in human placentas at term and birth weights
Elevation of C-reactive protein during the luteal phase in healthy adolescents
Hirsutism and oligomenorrhea are appropriate screening criteria for polycystic ovary syndrome in adolescents
Insulin autoimmune syndrome. Report of two cases
Insulin autoimmune syndrome. Report of two cases [Síndrome de hipoglicemia autoinmune. Primeros casos en Chile]
Leuprolide acetate-stimulated androgen response during female puberty
Severe vitamin D deficiency in children from Punta Arenas, Chile: Influence of nutritional status on the response to supplementation [Deficiencia severa de vitamina D en niños de Punta Arenas, Chile: Influencia de estado  nutricional en la respuesta a suplementación]
Effects of levothyroxine on growth hormone (gh) sensitivity in children with idiopathic short stature
Effects of thyroid hormone on the GH signal transduction pathway
IGF-IR Signal Transduction Protein Content and Its Activation by IGF-I in Human Placentas: Relationship with Gestational Age and Birth Weight
Serum Fibroblast Growth Factor 21 Levels Are Inversely Associated with Growth Rates in Infancy
Testicular function during adolescence in boys with type 1 diabetes mellitus ( T1D): absence of hypogonadism and differences in endocrine profile at the beginning and end of puberty
Accelerated early pubertal progression, ovarian morphology, and ovarian function in prospectively followed low birth weight (LBW) girls
Cortisol hyporesponsiveness to the low dose ACTH test is a frequent finding in a pediatric population with type 1 diabetes mellitus
Differences in Body Composition and Resting Energy Expenditure in Childhood in Preterm Children Born with Very Low Birth Weight
Effects of smoking on plasma antimullerian hormone concentrations among infertile women
El hábito de fumar se asocia a baja concentración plasmática de hormona antimülleriana en mujeres infértiles
Metformin for the Treatment of Hyperandrogenism in Adolescents with Type 1 Diabetes Mellitus
Microstructural Brain and Multivoxel Spectroscopy in Very Low Birth Weight Infants Related to Insulin-Like Growth Factor Concentration and Early Growth
Phosphotyrosine phosphatases in GH-stimulated skin fibroblasts from children with idiopathic short stature
Expression of SOCS1, SOCS2, and SOCS3 in growth hormone-stimulated skin fibroblasts from children with idiopathic short stature
Leptin and IGF-I/II during the first weeks of life determine body composition at 2 years in infants born with very low birth weight
Acid-Labile Subunit (ALS) Gene Expression and Protein Content in Human Placentas: Differences According to Birth Weight
Bone mass and sex steroids in postmenarcheal adolescents and adult women with Type 1 diabetes mellitus
Early onset of primary hypogonadism revealed by serum anti-Mullerian hormone determination during infancy and childhood in trisomy 21
Effects of Prenatal Ethanol Exposure on Postnatal Growth and the Insulin-Like Growth Factor Axis
Elevated anti-Mullerian hormone (AMH) and inhibin B levels in prepubertal girls with type 1 diabetes mellitus
Ghrelin Plasma Levels in Patients with Idiopathic Short Stature
Hipovitaminosis D en pacientes pediátricos en terapia de sustitución renal
Hypovitaminosis D in pediatric patients on renal replacement therapy
Ovarian function in adolescents with McCune-Albright syndrome
Ovulation rate in adolescents with type 1 diabetes mellitus
Polycystic ovarian morphology in adolescents with regular menstrual cycles is associated with elevated anti-Mullerian hormone
Polycystic ovarian morphology in postmenarchal adolescents
Expression and Protein Content of IGF-I and IGF-I Receptor in Placentas from Small, Adequate and Large for Gestational Age Newborns
Leuprolide acetate gonadotrophin response patterns during female puberty
Pancreatic VIPoma. Report of one case
Anti-Mullerian hormone and inhibin B levels as markers of premature ovarian aging and transition to menopause in type 1 diabetes mellitus
Changes in Nocturnal Leptin and Insulin Concentrations in Prepubertal Low Birth Weight Children after Administration of the IGF-I/IGFBP-3 Complex
Comparison of three doses of leuprolide acetate in the treatment of central precocious puberty: preliminary results
Differences in Body Composition and Energy Expenditure in Prepubertal Children Born Term or Preterm Appropriate or Small for Gestational Age
Differences in expression and activity of 11 beta-hydroxysteroid dehydrogenase type 1 and 2 in human placentas of term pregnancies according to birth weight and gender
Expression and Activity of 11 beta-Hydroxysteroid Dehydrogenase Type 1 Enzyme in Subcutaneous and Visceral Adipose Tissue of Prepubertal Children
IGF-IR/ERK content and response to IGF-I and insulin in adipocytes from small for gestational age children
The IGF-I Response to Growth Hormone Is Related to Body Mass Index in Short Children with Normal Weight
Adiponectin serum levels and their relationships to androgen concentrations and ovarian volume during puberty in girls with type 1 diabetes mellitus
Ala54Thr polymorphism of the fatty acid-binding protein 2 gene (intestinal-type FABP) is associated with changes in insulin sensitivity in SGA pubertal girls
Carotid Intima-Media Thickness as a Cardiovascular Risk Marker in Pediatric End-Stage Renal Disease Patients on Dialysis and in Renal Transplantation
Relationship between insulin sensitivity and IGF-I sensitivity in low birth weight prepubertal children
Adrenarche in Prader-Willi syndrome appears not related to insulin sensitivity and serum adiponectin
Comparison of leptin levels, body composition and insulin sensitivity and secretion by OGTT in healthy, early pubertal girls born at either appropriate- or small-for-gestational age
Gonadal function in low birth weight infants: A pilot study
Hormonal profile in women with polycystic ovarian syndrome with or without type 1 diabetes mellitus
Relationship between nocturnal growth hormone concentrations, serum IGF-I/IGFBP-3 levels, insulin sensitivity and GH receptor allelic variant in small for gestational age children
Comparison of clinical, ultrasonographic, and biochemical differences at the beginning of puberty in healthy girls born either small for gestational age or appropriate for gestational age: Preliminary results
Diagnostic criteria for polycystic ovary syndrome and ovarian morphology in women with type 1 diabetes mellitus
Effects of the IGF-I/IGFBP-3 complex on GH and ghrelin nocturnal concentrations in low birth weight children
IGF-I sensitivity in small for gestational age children
Longitudinal changes in insulin-like growth factor-I, insulin sensitivity, and secretion from birth to age three years in small-for-gestational-age children
Treatment of central precocious puberty with triptorelin 11.25 mg depot formulation
Hormonal profile and endometrial morphology in letrozole-controlled ovarian hyperstimulation in ovulatory infertile patients
Longitudinal changes in insulin sensitivity and secretion from birth to age three years in small- and appropriate-for-gestational-age children
Low risk of impaired testicular sertoli and Leydig cell functions in boys with isolated hypospadias
Ovarian function during puberty in girls with type 1 diabetes mellitus: Response to Leuprolide
Adiponectin levels in the first two years of life in a prospective cohort: Relations with weight gain, leptin levels and insulin sensitivity
Determinants of insulin sensitivity and secretion in very-low-birth-weight children
Molecular study of the 3 beta-hydroxysteroid dehydrogenase gene type II in patients with hypospadias
Selective intra arterial calcium stimulation for the localization of insulinomas. Report of two cases
TGF-I and insulin sensitivity and secretion in small for gestational age (SGA) versus appropriate for gestational age (AGA) at 1 year
Glucose and lipid metabolism in small for gestational age infants at 48 hours of age
Insulin sensitivity and secretion are related to catch-up growth in small-for-gestational-age infants at age 1 year: Results from a prospective cohort
Fasting and post-glucose ghrelin levels in SGA infants: Relationships with size and weight gain at one year of age
Regulation of steroid synthesis and apoptosis by insulin-like growth factor I and insulin-like growth factor binding protein 3 in human corpus luteum during the midluteal phase
Effect of nitric oxide on the expression of insulin-like growth factors and insulin-like growth factor binding proteins throughout the lifespan of the human corpus luteum
Effect of nitrix oxide on the expression of insulin-like growth factors and insulin-like growth factor binding proteins throughout the lifespan of the human corpus luteum
Normative values of growth hormone binding protein (GHBP) for a Chilean pediatric population
Nitric oxide induces apoptosis in the human corpus luteum in vitro
Relationship between serum growth hormone binding protein levels and height in young men

Abstract (31)

Multifollicular ovaries (MFO) diagnosed during adolescence: clinical findings, and hormonal profile, including anti-mullerian (AMH) hormone and inhibin b (INHB) levels
STEROID WITHDRAWAL IMMUNOSUPPRESSION IN FGF23/KLOTHO AND IGF-I/IGFBP3 AXIS IN PEDIATRIC KIDNEY TRANSPLANTATION
ANTI-MULLERIAN HORMONE AND INHIBIN B LEVELS ARE ELEVATED IN NON-HYPERANDROGENIC ADOLESCENTS WITH POLYCYSTIC OVARIAN MORPHOLOGY (PCOM)
DIFFERENCES IN PLACENTAL INSULIN-LIKE GROWTH FACTOR-II DISTRIBUTION IN PREGNANT DIABETIC RATS
Polycystic ovary morphology is a frequent finding in healthy postmenarchal adolescents during the second decade of life
Serum Levels of Anti-Mullerian Hormone (AMH) and Inhibin during Puberty in Healthy Girls Born Either Small for Gestational Age (SGA) or Appropriate for Gestational Age (AGA).
Age at menarche in Chilean adolescents with polycycstic ovary syndrome (PCOS)
Changes in somatotrophic hormone concentrations in cord blood from small (SGA), appropriate (AGA) and large (LGA) for gestational age newborns
Clinical and gonadal hormones characteristic during puberty in unselected girls born ether small for gestational age (SGA) or appropiate for gestational age (AGA)
Differences in IGF-I/IGF-IR/IRS-1/ERK/AKT protein contents in human term placentas according birth weight
Intracellular response to IGF-I in fibroblast cultures from children with idiopathic short stature
Metformin for the treatment of hyperandrogenism in adolescents with type 1 diabetes mellitus: a double blind randomized study
Polycystic ovary morphology (PCOM) does not affect ovulatory function in healthy postmenarcheal adolescents
Androgen receptor CAG/GGC repeats in prepubertal girls with hypertricosis
Differences in the intracellular signal transduction components for IGF-IR in human term placentas from small, adequate and large for gestational age new borns
Expression and activity of 11 beta-OH-steroid dehydrogenase (11 beta-HSDs) type 1 and 2 enzymes in human term placenta from small (SGA), appropriate (AGA) and large (LGA) for gestational age new borns
Expression of 11 beta-hydroxysteroid dehydrogenase (11 beta HSD) type 1 and 2 enzymes in human term placenta from small (SGA), adecuate (AGA) and large (LGA) for gestational age new borns
Expression of IGF-I and IGF-I receptor (IGF-IR) in placentas from small for gestational age newborns: Relation with birth length
Nocturnal concentrations of free T3 (fT3) and free T4 (fT4) increase after the administration of the IGF-I/IGFBP-3 complex (Iplex) in small for gestational age prepubertal children
NTproCNP plasma levels in patients with idiopathic short stature
Placental P450 aromatase (Arom) expression in deliveries of male and female children born adequate (Aga) or small for gestational age (Sga)
Pubertal characteristic in healthy girls small for gestational age (SGA) compared with girls appropriate for gestational age (AGA)
Expression of 11 beta-OH-steroid dehydrogenase (11 beta-HSDS) type 1 and 2 enzymes in human term placenta from small (SGA), appropriate (AGA) and large (LGA) for gestational age new borns
Frequency of ovulatory cycles in young adolescents with type 1 diabetes Mellitus
GH sensitivity is related to nutritional status in children with normal BMI
Higher expression of IGF-I and IGF-I receptor (IGF-IR) in placentas from small for gestational age newborns: Relation with birth length
Increased ovarian volume in girls with isolated precocious pubarche
Leptin nocturnal concentrations increase after the administration of the IGF-I/IGFBP-3 complex in small for gestational age prepubertal children
Lower number of GGC androgen receptor gene repeats in prepubertal girls with hypertricosis
Ovulation in normal postmenarcheal adolescents with polycystic ovary morphology (PCOM)
Controlled study of arginine-supplemented diet in burn pediatric patients: Immunological and metabolic effect

CaseReport (1)

VIPoma pancreático: Caso clínico

ConferencePaper (1)

Controlled study of enteral arginine-supplemention in burned children: IGF-I effect

Proyecto (17)

Premature adrenarche. Unanswered questions
Contraception in Type I Diabetes
PREMATURE ANDRENARCHE AND EFFECTS ON OVARIAN FUNCTION, PUBERTAL TEMPO AND METABOLIC RISK
FOLATE-RELATED ONE CARBON METABOLISM REGULATES THE EXPRESSION OF GENES INVOLVED IN FETAL GROWTH AND STRESS IN HUMAN PLACENTA. A LINK TO FETAL PROGRAMMING?
INTRACELLULAR SIGNALING INDUCED BY IGF-I IN HUMAN PRETERM AND TERM PLACENTAS. MODULATION BY THE KLOTHO/FGF SYSTEM
ESTROGENS AND TYPE 1 DIABETES MELLITUS
EFECTOS DE LA EDAD, GENERO Y DESARROLLO PUBERAL SOBRE LA SENSIBILIDAD A HORMONA DEL CRECIMIENTO EN EL SER HUMANO.
ESTUDIO DE CRECIMIENTO LONGITUDINAL Y DETERMINANTES DE LA SENSIBILIDAD A INSULINA EN NIQOS PREMATUROS DE MUY BAJO PESO ( LT; DE 1500 GRS) NACIDOS ADECUADOS O PEQUEQOS PARA LA EDAD GESTACIONAL
"TRANSDUCCION DE SEÑAL PARA HORMONA DEL CRECIMIENTO E IGF-I EN NIÑOS CON TALLA BAJA IDIOPATICA".
RELACION ENTRE EL SISTEMA SOMATOTROFICO PLACENTARIO Y EL CRECIMIENTO PRE Y POSTNATAL EN HUMANOS.
FUNCION OVARICA EN ADOLESCENTES CON DIABETES MELLITUS TIPO 1.
IMPACTO DEL RETRASO DE CRECIMIENTO INTRAUTERINO EN LA FUNCION GONADAL Y SU RELACION CON LA COMPOSICION CORPORAL EN EL SEXO FEMENINO.
ESTUDIO DE SUSTRATOS INTRACELULARES PARA IGF-1 E INSULINA EN NINOS CON RETARDO DEL CRECIMIENTO INTRAUTERINO.
MUTACIONES DE LA ENZIMA 3 B HIDROXIESTEROIDE DESHIDROGENASA EN PACIENTES CON HIPOSPADIAS IDIOPATICA.
EFECTOS DE LA SUPLEMENTACION CON ZINC SOBRE EL EJE DE HORMONA DE CRECIMIENTO-EFECTOR, EN NINOS CON TALLA BAJA IDIOPATICA.
DIAGNOSTICO PRECOZ DE GESTACION EN BOVINOS MEDIANTE LA DETECCION DE UNA NUEVA PROTEINA PLACENTARIA BOVINA (BUTPH) ESTUDIO DE FACTIBILIDAD EN TERRENO
CARACTERIZACION Y DETECCION DE UNA NUEVA PROTEINA PLACENTARIA=> HORMONA UTEROTR UTEROTROFICA PLACENTARIA (UTPH) PARA EL DIAGNOSTICO PRECOZ DE GESTACION EN VACUNO.
112
Germán Iñiguez

INSTITUTO DE INVESTIGACIONES MATERNO INFANTIL, FACULTAD DE MEDICINA, UNIVERSIDAD DE CHILE

Santiago, Chile

27
Maria Mericq

Profesor Titular

IDIMI

Universidad de Chile

Santiago, Chile

10
Claudio Villarroel

Sub-Director

INSTITUTO DE INVESTIGACIONES MATERNO INFANTIL (IDIMI)

Santiago, Chile

8
Sylvia Asenjo

Profesor Titular

Pediatría

Universidad de Concepción

Concepción, Chile

5
Maria Vega

Academico Profesora Titular

Obstetricia y Ginecologia Campus Norte

UNIVERSIDAD DE CHILE - FACULTAD DE MEDICINA

Santiago, Chile

5
Gabriel Cavada

Académico, Jefe de Programa

Instituto de Salud Poblacional

Universidad de Chile

Santiago, Chile

2
LORENA RODRIGUEZ

Academic

Public Health School

Universidad de Chile

Santiago, Chile

2
Alejandra Lanas

Profesor asistente

Medicina Interna

Hospital Clínico de la Universidad de Chile

Santiago, Chile

2
Paulina Merino

INSTITUTO DE INVESTIGACIONES MATERNO INFANTIL (IDIMI), UNIV CHILE

Santiago, Chile

2
Enrica Pittaluga

Médico asistencial

Pediatría

Complejo asistencial Dr Sótero del Río

Santiago, Chile

2
Carolina Gonzalez

médico

Pediatría

Clínica Alemana de Santiago

Santiago, Chile

2
Fernando Carrasco

Médico nutriólogo

Nutrición y Vida Saludable

Clínica Las Condes

Santiago, Chile

1
daniel hevia

Investigador PhD

Inmunologia

Universidad de Chile

santiago, Chile

1
Julián Varas

Coordinador Médico Centro de Simulación, miembro directorio Simulación UC

Departamento de Cirugía Digestiva

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

Santiago, Chile

1
Paulina Ormazábal

Docente investigador

Facultad de Ciencias para el cuidado de la Salud

Universidad San Sebastián

Santiago, Chile

1
Viola Pinto

Jefe

Hospital de niños Dr. Exequiel González Cortés

Santiago, Chile

1
Frans Fuentes

STAFF

PROGRAMA DE REPRODUCCIÓN

IDIMI-FACULTAD DE MEDICINA-UNIVERSIDAD DE CHILE

Santiago, Chile

1
Bárbara Echiburú

Profesor Asistente

Medicina Interna

Universidad de Chile

Santiago, Chile

1
Pablo Céspedes

Director Programa Fertilizacion Asistida

IDIMI

Santiago, Chile

1
Arturo Borzutzky

Chief; Associate Professor

Department of Pediatric Infectious Diseases and Immunology

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

1
Sandra Hirsch

planta

ECRAN

INTA, UNIVERSIDAD DE CHILE

Santiago, Chile

1
Claudia Urquidi

Profesor Asociado

Salud Publica y Epidemiología

UNIVERSIDAD DE LOS ANDES

Santiago, Chile

1
Nicolas Crisosto

Profesor Asistente

Medicina Interna Occidente

Universidad de Chile

Santiago, Chile

1
Karl Pingelll

Information and Management Control

Associative Research Program

CONICYT

Santiago, Chile

1
Sebastian San Martin

Profesor Titular

Anatomía

UNIVERSIDAD DE VALPARAISO

Valparaiso, Chile

1
Erika Kopplin

Investigador de apoyo

Escuela de Psicología

Pontificia Universidad Católica de Chile

Las Condes, Chile

1
Alejandro Martinez

Profesor Asociado

Pediatría

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago de Chile, Chile

1
Luigi Devoto

PROFESOR TITULAR

INSTITUTO DE INVESTIGACIONES MATERNO INFANTIL,FACULTAD DE MEDICINA, UNIVERSIDAD DE CHILE

Santiago, Chile

1
IVAN CASTILLO

PATOLOGO

HOSPITAL REGIONAL DE TALCA

TALCA, Chile