Man

Maria Veronica Mericq Guila

Profesor Titular

Universidad de Chile

Santiago, Chile

Líneas de Investigación


Prenatal and postnatal growth and metabolism determinants. I have explored the impact of being born small for gestational age and premature in growth and metabolism and currently exploring the role of exaggerated adrenarche in these targets

Educación

  •  Medical Doctor, UNIVERSIDAD DE VALPARAISO. Chile, 1988
  •  Pediatra, UNIVERSIDAD DE CHILE. Chile, 1992
  •  Endocrinologia Infantil , UNIVERSIDAD DE CHILE. Chile, 1995
  •  Endocrinologia Infantil , NATIONAL INSTITUTE OF HEALTH. Estados Unidos, 1998

Experiencia Académica

  •   Professor Part Time

    UNIVERSIDAD DE CHILE

    Medicine

    Santiago, Chile

    1998 - A la fecha

Experiencia Profesional

  •   Medico Pediatra endocrinologo infantil Other

    Clinica Las condes

    Santiago, Chile

    1998 - A la fecha


 

Article (131)

Increased Burden of Rare Sequence Variants in GnRH-Associated Genes in Women With Hypothalamic Amenorrhea.
Phenotypic continuum between Waardenburg syndrome and idiopathic hypogonadotropic hypogonadism in humans with SOX10 variants
Total and Central Adiposity Are Associated With Age at Gonadarche and Incidence of Precocious Gonadarche in Boys
.- High DHEAS in girls associates to earlier pubertal maturation ,mild increase in androgens throughout puberty without affecting post menarche ovarian morphology,
A Polygenic Risk Score Suggests Shared Genetic Architecture of Voice Break With Early Markers of Pubertal Onset in Boys
Disease characteristics of MCT8 deficiency: an international, retrospective, multicentre cohort study
Early Obesity: Risk Factor for Fatty Liver Disease
Neonatal Diabetesdue to potasiumchannel mutation: response to sulfonylurea according to the genotype
Obesity and Related Metabolic Biomarkers and Its Association with Serum Levels of Estrogen in Pre-pubertal Chilean Girls
Reproductive Hormones During Pubertal Transition in Girls With Transient Thelarche
Age at Pubertal Development in a Hispanic-Latina Female Population: Should the Definitions Be Revisited?
Glucocorticoids Decrease Longitudinal Bone Growth in Pediatric Kidney Transplant Recipients by Stimulating the FGF23/FGFR3 Signaling Pathway
Impact of route of administration on genotoxic oestrogens concentrations using oral vs transdermal oestradiol in girls with Turner syndrome
Intrauterine Twin Discordancy and Partial Postnatal Catch-up Growth in a Girl with a Pathogenic IGF1R Mutation
Klotho Gene and Protein in Human Placentas According to Birth Weight and Gestational Age
Psychometric performance of the Quality of Life in Short Stature Youth (QoLISSY) questionnaire in a randomized open-label comparator trial in idiopathic short stature
Quality of Life in Adolescent Boys with Idiopathic Short Stature: Positive Impact of Growth Hormone and Aromatase Inhibitors
Role of the Androgen Receptor Gene CAG Repeat Polymorphism on the Sequence of Pubertal Events and Adiposity in Girls with High Dehydroepiandrosterone Sulfate Level
Use of Gonadotropin-Releasing Hormone Analogs in Children: Update by an International Consortium
Childhood and adolescent phenol and phthalate exposure and the age of menarche in Latina girls
Discordance in the Dependence on Kisspeptin Signaling in Mini Puberty vs Adolescent Puberty: Human Genetic Evidence
Faster ticking rate of the epigenetic clock is associated with faster pubertal development in girls
Inverse association between estrogen receptor-alpha DNA methylation and breast composition in adolescent Chilean girls
Is There a Difference between Ultrasonographic (US) Uterine Changes of Oral Versus Transdermal (TD) 17? Estradiol (17? E2) in Girls with Turner Syndrome (TS)? Own Experience and Literature Review
Patterns of Infancy Growth and Metabolic Hormonal Profile Are Different in Very-Low-Birth-Weight Preterm Infants Born Small for Gestational Age Compared to Those Born Appropriate for Gestational Age
Precocious pubertal events in Chilean children: ethnic disparities
Early BMI Gain and Later Height Growth Predicts Higher DHEAS Concentrations in 7-Year-Old Chilean Children
Genetic Variation of Follicle-Stimulating Hormone Action Is Associated With Age at Testicular Growth in Boys
High DHEAS Is Associated With Earlier Pubertal Events in Girls But Not in Boys
Pseudoautosomal abnormalities in terminal AZFb plus c deletions are associated with isochromosomes Yp and may lead to abnormal growth and neuropsychiatric function
Pseudohypoparathyroidism type 1B associated with assisted reproductive technology
Copy number variation analysis in adults with catatonia confirms haploinsufficiency of SHANK3 as a predisposing factor
Factors associated with post-menarcheal growth: results of a longitudinal study in Chilean girls from different socioeconomic statuses
Prepubertal Adiposity, Vitamin D Status, and Insulin Resistance
Prospective functional classification of all possible missense variants in PPARG
Randomized Trial of Aromatase Inhibitors, Growth Hormone, or Combination in Pubertal Boys with Idiopathic, Short Stature
The effects of pre-pregnancy BMI and maternal factors on the timing of adiposity rebound in offspring.
A Deletion of More than 800 kb Is the Most Recurrent Mutation in Chilean Patients with SHOX Gene Defects
An XRCC4 Splice Mutation Associated With Severe Short Stature, Gonadal Failure, and Early-Onset Metabolic Syndrome
Heterozygous Mutations in Natriuretic Peptide Receptor-B (NPR2) Gene as a Cause of Short Stature
Leuprolide acetate-stimulated androgen response during female puberty
Ultrasensitive estrogen levels at 7 years of age predict earlier thelarche: evidence from girls of the growth and obesity Chilean cohort
24-Month Use of Once-Weekly GH, LB03002, in Prepubertal Children With GH Deficiency
Breast bud detection: a validation study in the Chilean Growth Obesity Cohort Study
Copy number variants in patients with short stature
Functionally compromised CHD7 alleles in patients with isolated GnRH deficiency
IGF-IR Signal Transduction Protein Content and Its Activation by IGF-I in Human Placentas: Relationship with Gestational Age and Birth Weight
Serum Fibroblast Growth Factor 21 Levels Are Inversely Associated with Growth Rates in Infancy
Accelerated early pubertal progression, ovarian morphology, and ovarian function in prospectively followed low birth weight (LBW) girls
Cortisol hyporesponsiveness to the low dose ACTH test is a frequent finding in a pediatric population with type 1 diabetes mellitus
Differences in Body Composition and Resting Energy Expenditure in Childhood in Preterm Children Born with Very Low Birth Weight
Metabolic Effects of Oral Versus Transdermal 17 beta-Estradiol (E-2): A Randomized Clinical Trial in Girls With Turner Syndrome
Microstructural Brain and Multivoxel Spectroscopy in Very Low Birth Weight Infants Related to Insulin-Like Growth Factor Concentration and Early Growth
Obesity is positively associated with dehydroepiandrosterone sulfate concentrations at 7 y in Chilean children of normal birth weight
Steroid Withdrawal in Pediatric Kidney Transplant Allows Better Growth, Lipids and Body Composition: A Randomized Controlled Trial
The phenotype of Floating-Harbor syndrome: clinical characterization of 52 individuals with mutations in exon 34 of SRCAP
CBG Santiago: A Novel CBG Mutation
Clinical and genetic characteristics and effects of long-term growth hormone therapy in a girl with Floating-Harbor syndrome
How to Optimally Manage Growth Hormone Therapy: Survey of Chilean Pediatric Endocrinologists
Intereses y perspectiva sobre la carrera de medicina: un contraste entre estudiantes de medicina de primero y séptimo año
Leptin and IGF-I/II during the first weeks of life determine body composition at 2 years in infants born with very low birth weight
Prevalence of components of the metabolic syndrome according to birthweight among overweight and obese children and adolescents
When Genetic Load Does Not Correlate with Phenotypic Spectrum: Lessons from the GnRH Receptor (GNRHR)
Benefits of Supplemented Preterm Formulas on Insulin Sensitivity and Body Composition after Discharge from the Neonatal Intensive Care Unit
Comparative analysis of clinical, biochemical and genetic aspects associated with bone mineral density in small for gestational age children
Expanding the Phenotype and Genotype of Female GnRH Deficiency
Frequency of Familial Hyperaldosteronism Type 1 in a Hypertensive Pediatric Population Clinical and Biochemical Presentation
Ghrelin Plasma Levels in Patients with Idiopathic Short Stature
Latin American Consensus: Children Born Small for Gestational Age
Genetic variations of follicle stimulating hormone receptor are associated with polycystic ovary syndrome
Haplotype Analysis of the Promoter Region of Phosphodiesterase Type 8B (PDE8B) in Correlation with Inactivating PDE8B Mutation and the Serum Thyroid-Stimulating Hormone Levels
Insulin resistance in children: Consensus, perspective, and future directions
Leuprolide acetate gonadotrophin response patterns during female puberty
Maternally Transmitted and Food-Derived Glycotoxins A factor preconditioning the young to diabetes?
An Intronic Mutation is Associated with Prolactinoma in a Young Boy, Decreased Penetrance in his Large Family, and Variable Effects on MEN1 mRNA and Protein
Comparison of three doses of leuprolide acetate in the treatment of central precocious puberty: preliminary results
Differences in expression and activity of 11 beta-hydroxysteroid dehydrogenase type 1 and 2 in human placentas of term pregnancies according to birth weight and gender
Expression and Activity of 11 beta-Hydroxysteroid Dehydrogenase Type 1 Enzyme in Subcutaneous and Visceral Adipose Tissue of Prepubertal Children
Familial Tumoral Calcinosis Caused by a Novel FGF23 Mutation: Response to Induction of Tubular Renal Acidosis with Acetazolamide and the Non-Calcium Phosphate Binder Sevelamer
Mild fasting hyperglycemia in children: high rate of glucokinase mutations and some risk of developing type 1 diabetes mellitus
E180splice Mutation in the Growth Hormone Receptor Gene in a Chilean Family with Growth Hormone Insensitivity: A Probable Common Mediterranean Ancestor
Impact of being born small for gestational age on onset and progression of puberty
Relationship between insulin sensitivity and IGF-I sensitivity in low birth weight prepubertal children
Adiposidad visceral y su asociación con lípidos séricos e insulinemis en adolescentes obesas
Adrenarche in Prader-Willi syndrome appears not related to insulin sensitivity and serum adiponectin
Comparison of leptin levels, body composition and insulin sensitivity and secretion by OGTT in healthy, early pubertal girls born at either appropriate- or small-for-gestational age
Corticosteroid-induced osteoporosis in children: outcome after two-year follow-up, risk factors, densitometric predictive cut-off values for vertebral fractures
Relationship between nocturnal growth hormone concentrations, serum IGF-I/IGFBP-3 levels, insulin sensitivity and GH receptor allelic variant in small for gestational age children
Comparison of clinical, ultrasonographic, and biochemical differences at the beginning of puberty in healthy girls born either small for gestational age or appropriate for gestational age: Preliminary results
Effectiveness of leuprolide acetate therapy every three months in central precocious puberty
Longitudinal changes in insulin-like growth factor-I, insulin sensitivity, and secretion from birth to age three years in small-for-gestational-age children
Prematurity and insulin sensitivity
Longitudinal changes in insulin sensitivity and secretion from birth to age three years in small- and appropriate-for-gestational-age children
Restricción del crecimiento fetal e insulinorresistencia: Nuevos hallazgos y revisión de la literatura
Adiponectin levels in the first two years of life in a prospective cohort: Relations with weight gain, leptin levels and insulin sensitivity
Determinants of insulin sensitivity and secretion in very-low-birth-weight children
Drugs and hormones used to treat pediatric and adolescent reproductive endocrine disorders.
Nuevos esquemas de tratamiento con insulina en niños y dolescentes con Diabetes Mellitus tipo 1 (DM1) en un Hospital Público
Glucose and lipid metabolism in small for gestational age infants at 48 hours of age
Insulin gene VNTR genotype is associated with insulin sensitivity and secretion in infancy
Insulin sensitivity and secretion are related to catch-up growth in small-for-gestational-age infants at age 1 year: Results from a prospective cohort
Resultados de un programa multidisciplinario de tratamiento intensificado de la Diabetes Mellitus tipo 1 (DM1) en un Hospital Público
Effects of treatment with growth hormone alone or in combination with LHRH-analog on bone mineral density in pubertal growth hormone deficient patients
Fasting and post-glucose ghrelin levels in SGA infants: Relationships with size and weight gain at one year of age
.- Study of growth hormone sensitivity in chilean patients with idiopathic short stature
Effects of oral administration of ibutamoren mesylate, a nonpeptide growth hormone secretagogue, on the growth hormone-insulin-like growth factor I axis in growth hormone-deficient children
Estudio clínico-molecular de pacientes chilenas con síndrome de McCune-Albright
Normative values of growth hormone binding protein (GHBP) for a Chilean pediatric population
Normative values of growth hormone binding protein (GHBP) for a Chilean pediatric population Valores de referencia para proteína transportadora de hormona de crecimiento en una población pediátrica normal
Regulation of growth plate chondrogenesis by bone morphogenetic protein-2
Study of GH sensitivity in Chilean patients with idiopathic short stature
Near final height in pubertal growth hormone (GH)-deficient patients treated with GH alone or in combination with luteinizing hormone-releasing hormone analog: Results of a prospective, randomized trial
Near final height in pubertal growth hormone deficient patients treated with growth hormone alone or in combination with lhrh-a: results of a prospective, randomized trial. Mericq V, Eggers M, Avila A, Cutler GB ,Cassorla F
Regulation of Fetal Rat Bone Growth by C-Type Natriuretic Peptide and cGMP,.
Relationship between serum growth hormone binding protein levels and height in young men
Retinoic acid is a potent regulator of growth plate chondrogenesis
Autosomal dominant hypoparathyroidism associated with short stature and premature osteoarthritis
Estrogen levels in girls with premature thelarche compared to normal prepubertal girls as determined by an ultrasensitive recombinant cell bioassay.
Usefulness of the Measurement of Insulin-Like Growth Factor (IGF-I) and IGF-1 Binding protein-3 (IGFBP-3) for the Diagnosis of Growth Hormone (GH) Deficiency in Children
Effects of eight months treatment with graded doses of a growth – hormone releasing peptide in GH- deficient children
High fluid intake increases urine free cortisol excretion in normal subjects
Optimizing growth hormone therapy during therapy
Two 5’ splice site mutations in the growth hormone gene,causing autosomal dominant growth hormone deficiency
Effects of LHRH-Analog induced pubertal delay in growth hormone deficient children treated with growth hormone : preliminary results.
Growth hormone responses to growth hormone releasing peptide (GHRP) and to growth hormone releasing hormone (GHRH) in growth hormone deficient children
The effect of a Beta 1- Adrenergic Blocking agent enhances the growth response to growth hormone releasing hormone (GHRH) therapy in growth hormone (GH) deficient Children
Effects of Ketoconazole on Rat Ovarian Steroidogenic enzimatic activities
Direct effect of the Luteinizing Hormone Releasing Hormone Analog D-Trp6-PRO9-NET-LHRH on Ratt Ovarian Steroidogenesis
The effects of Prolactin (PRL) on rat testicular Steroidogenic Enzyme Activities
Direct effects of the Luteinizing Hormone Releasing Hormone Analog d-Trp6-Pro9-NET-LHRH on rat Testicular Steroidogenesis
The effects of Prolactin on Rat Ovarian function

Errata (1)

Growth Retardation in Children with Kidney Disease (vol 2013, 970946, 2013)

Letter (3)

Hypoglycaemia following diabetes remission in patients with 6q24 methylation defects: expanding the clinical phenotype
Mutation in PDE8B, a cyclic AMP-specific phosphodiesterase in adrenal hyperplasia
Premature birth and insulin resistance [3](multiple letters)

Review (5)

Long-term metabolic risk among children born premature or small for gestational age
Growth Retardation in Children with Kidney Disease
Metabolic syndrome in children born small-for-gestational age [Síndrome metabólica em crianças nascidas pequenas para a idade gestacional]
Insulin Resistance Markers in Children
Nutrition, child growth, and chronic disease prevention
140
Maria Mericq

Profesor Titular

IDIMI

Universidad de Chile

Santiago, Chile

15
Camila Corvalan

Assistant Professor

UNIVERSIDAD DE CHILE, INTA

SANTIAGO, Chile

9
Ana Pereira

Profesor Asistente

INSTITUTO NUTRICIÓN Y TECNOLOGÍA DE LOS ALIMENTOS, UNIVERSIDAD DE CHILE

Santiago, Chile

5
Gabriel Cavada

Académico, Jefe de Programa

Instituto de Salud Poblacional

Universidad de Chile

Santiago, Chile

4
JOSE SANTOS

Full Professor

Department of Nutrition, Diabetes and Metabolism

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

Santiago, Chile

4
Sylvia Asenjo

Profesor Titular

Pediatría

Universidad de Concepción

Concepción, Chile

3
Ricardo Uauy

Professor

Pontificia Universidad Catolica de Chile

Santiago, Chile

3
Viola Pinto

Jefe

Hospital de niños Dr. Exequiel González Cortés

Santiago, Chile

3
Enrica Pittaluga

Médico asistencial

Pediatría

Complejo asistencial Dr Sótero del Río

Santiago, Chile

3
Claudia Urquidi

Profesor Asociado

Salud Publica y Epidemiología

UNIVERSIDAD DE LOS ANDES

Santiago, Chile

2
Luis Michea

PROFESOR ASOCIADO

PROGRAMA FISIOLOGIA Y BIOFISICA

UNIVERSIDAD DE CHILE

Santiago, Chile

2
Alejandro Martinez

Profesor Asociado

Pediatría

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago de Chile, Chile

2
Maria Garmendia

ACADEMICO

INSTITUTO DE NUTRICION Y TECNOLOGIA DE LSO ALIMENTOS

UNIVERSIDAD DE CHILE

SANTIAGO, Chile

2
Juliana Kain

Profesor Asociado

INTA

UNIVERSIDAD DE CHILE

SANTIAGO, Chile

2
Marcela Sjoberg

Assistant professor

Biología Celular y Molecular

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

Santiago, Chile

2
Alexies Dagnino

Full Professor

Physiology

UNIVERSIDAD DE VALPARAÍSO

Valparaíso, Chile

1
Martha Flórez

Profesional

Medicina

Instituto de Investigación Materno Infantil

Santiago, Chile

1
Erika Kopplin

Investigador de apoyo

Escuela de Psicología

Pontificia Universidad Católica de Chile

Las Condes, Chile

1
Lillian Bolte

Medico Staff

Pediatria

Hospital Roberto del Río

Santiago, Chile

1
Gustavo Cediel

POST DOCTORADO

NUTRITION

UNIVERSIDAD DE SAO PAULO

SAO PAULO, Brasil

1
Cristian Carvajal

Associate Professor

Endocrinologia

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

1
Fernando Carrasco

Médico nutriólogo

Nutrición y Vida Saludable

Clínica Las Condes

Santiago, Chile

1
Pamela Trejo

Endocrinologist

Internal Medicine

Clinica Alemana Santiago

Santiago, Chile

1
Marta Arriaza

Medico staff

Pediatría

Hospital Dr. Gustavo Fricke

Viña del Mar, Chile

1
Luis Toro

Profesor Asistente

Departamento de Medicina

Universidad de Chile

Santiago, Chile

1
Teresa Aravena

Profesor asistente

Medicina

UNIVERSIDAD DE CHILE

santiago, Chile

1
Helena Poggi

Coordinadora de Investiagción

División de Pediatría

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

1
Juan Gana

Gastroenterólogo Pediatra

Departamento de Gastroenterología y Nutrición Pediátrica.

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

1
Alberto Toso

Médico asistencial

Neonatología

Pontificia Universidad Católica de Chile

Santiago, Chile

1
Maria Taboada

Profesor Titular

Facultad de Ingeniería

UNIVERSIDAD DE ANTOFAGASTA

Antofagasta, Chile

1
JOSE MIRANDA

Estudiante de Doctorado

Nutrición, Diabetes y Metabolismo

Pontificia Universidad Católica de Chile

Santiago, Chile

1
Gigliola Alberti

profesora asistente

gastroenterologia y nutricion pediatrica

pontificia universidad católica de chile

santiago, Chile

1
Carlos Fardella

Profesor Titular

Endocrinología

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

1
Paulina Merino

INSTITUTO DE INVESTIGACIONES MATERNO INFANTIL (IDIMI), UNIV CHILE

Santiago, Chile

1
Pablo León

Asistente de Investigación

Ciencias Biomedicas

Universidad de Chile

Santiago, Chile

1
Alejandro Maturana

PROFESOR ASISTENTE DE PSIQUIATRIA

PSIQUIATRIA

Universidad de Chile

SATIAGO, Chile

1
Carolina Loureiro

Instructor Adjunto

Pediatria

Pontificia Universidad Católica de Chile

Santiago, Chile

1
Sebastian San Martin

Profesor Titular

Anatomía

UNIVERSIDAD DE VALPARAISO

Valparaiso, Chile