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Marcela Katherine Sjoberg Herrera

Assistant professor

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

Santiago, Chile

Epigenetic mechanisms regulating gene expression; Dynamics of DNA methylation in the immune system; Non-coding RNAs; Interplay between metabolic sensors and regulators of genome function; Mapping immune cell diversity using across Latin America

Doctor en Biología Celular, Molecular y Neurociencias , UNIVERSIDAD DE CHILE. Chile, 2006
Ingeniero en Biotecnología Molecular, UNIVERSIDAD DE CHILE. Chile, 2002

Assistant professor Full Time

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

Facultad de Ciencias Biológicas

Santiago, Chile

2016 - A la fecha
Associate professor Full Time

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

Facultad de Ciencias Biológicas

Santiago, Chile

2023 - A la fecha

Ayudante curso Biología Celular

Universidad de Chile

Chile

1997 - 1998
Asistente de investigación proyecto Fondecyt 1970276

Universidad Católica de Chile

Chile

1999 - 1999
Estadía de investigación

René Descartes University

Francia

2003 - 2003
Estadía de investigación

Case Western Reserve University

Estados Unidos

2005 - 2005
Estudiante de Doctorado

Universidad de Chile

Chile

2001 - 2006
Postdoctorado - Career development fellow

IMPERIAL COLLEGE OF SCIENCE, TECHNOLOGY & MEDICINE

Reino Unido

2006 - 2010
Research Associate

University of Cambridge

Reino Unido

2012 - 2016
Postdoctoral Scientist

Wellcome Trust Sanger Institute

Reino Unido

2012 - 2016

Autor(es):Rojas, Pamela
Título: "Characterization of the effects induced by ADAR1 over long non-coding RNAs A-to-I editing and expression levels in breast cancer",
Institución: PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE, Doctorado/PhD, 2020

Autor(es):Rivera, Carlos
Título: "Unveiling non canonical roles for RCOR1 and RCOR2 transcriptional co-repressors",
Institución: PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE, Doctorado/PhD, 2020

Autor(es):Ballesteros, Rocío
Título: "La metilcitosina dioxigenasa Tet1: Factores de transcripción que regulan su expresión, isoformas y localización subcelular",
Institución: PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE, Magíster/Master/DEA, 2022

Autor(es):Villalobos, Daniela
Título: "Investigating TET proteins partners that control hydroxymetylated genes in the adaptive immune system",
Institución: PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE, Licenciatura/Bachillerato/Bachelor, 2020

Autor(es):Reinoso, María Javiera
Título: "Examining the binding of Tet1 and histone H3K4 trimethylation enzymes and their association to 5hmc marked genes in naïve CD4+ T cells",
Institución: PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE, Licenciatura/Bachillerato/Bachelor, 2020

Autor(es):Hernández, Macarena
Título: "Estudio de la asociación de proteínas lectoras de DNA metilado a genes hidroximetilados en linfocitos T CD4+ naïve",
Institución: PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE, Magíster/Master/DEA, 2019

Beca Doctorado

COMISION NACIONAL DE INVESTIGACION CIENTIFICA Y TECNOLOGICA

Chile, 2002

Beca CONICYT para financiar estudios de Doctorado en Chile
Beca Doctorado

COMISION NACIONAL DE INVESTIGACION CIENTIFICA Y TECNOLOGICA

Chile, 2001

Beca Instituto Milenio CBB P99-031-F para financiar estudios de doctorado en Chile
Postdoctoral Fellowship

MEDICAL RESEARCH COUNCIL

Reino Unido, 2006

MRC Career development fellowship of postdoctoral researcher


Modeling methyl-sensitive transcription factor motifs with an expanded epigenetic alphabet Viner, Coby; Ishak, Charles A.; Johnson, James; Walker, Nicolas J.; Shen, Shu Yi; Lardo, Santana M.; Ferguson-Smith, Anne C.; De Carvalho, Daniel D.; Hainer, Sarah J.; Bailey, Timothy L.; et al. Article ISI GENOME BIOLOGY (2024)
<i>OPA1</i> disease-causing mutants have domain-specific effects on mitochondrial ultrastructure and fusion Sjoberg-Herrera, Marcela K.; Eisnera, Veronica Article ISI PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2023)
Unveiling RCOR1 as a rheostat at transcriptionally permissive chromatin Rivera, Carlos; Lee, Hun-Goo; Lappala, Anna; Wang, Danni; Noches, Veronica; Olivares-Costa, Montserrat; Sjoberg-Herrera, Marcela Article ISI NATURE COMMUNICATIONS (2022)
Immune-related IncRNA LINC00944 responds to variations in ADAR1 levels and it is associated with breast cancer prognosis Article ISI LIFE SCIENCES (2021)
Needs for a Curricular Change in Primary and Secondary Education From the One Health Perspective: A Pilot Study on Pneumonia in Schools Pilar Sanchez, Maria; Duprat, Ximena G.; Mena, Alejandro; Cabal, Soledad; Figueroa, Daniela P. Article ISI FRONTIERS IN PUBLIC HEALTH (2021)
Comparative genomics reveals that loss of lunatic fringe (LFNG) promotes melanoma metastasis Velasco-Herrera, MD; van der Weyden, L; Nsengimana, J; Speak, AO; Bishop, DT; Jonsson, G; Newton-Bishop, J Article ISI SCOPUS Molecular Oncology (2018)
Identification, Characterization, and Heritability of Murine Metastable Epialleles: Implications for Non-genetic Inheritance Kazachenka, A; Bertozzi, TM; Sjoberg-Herrera, MK; Walker, N.; Gunning, R; Pahita, E; Adams S.; Adams, D. Article ISI CELL (2018)
Simulation-based benchmarking of isoform quantification in single-cell RNA-seq Westoby J.; Herrera, M.S.; Ferguson-Smith A.C. Article ISI SCOPUS Genome Biology (2018)
Sixteen diverse laboratory mouse reference genomes define strain-specific haplotypes and novel functional loci Lilue J.; Doran A.G.; Fiddes I.T.; Abrudan M.; Armstrong J.; Bennett R.; Chow W.; Collins J.; Czechanski A.; Danecek P.; et al. Article ISI SCOPUS Nature Genetics (2018)
The BRAF Pseudogene Functions as a Competitive Endogenous RNA and Induces Lymphoma In Vivo Karreth, Florian A.; Sjoberg, Marcela; Keane, Thomas M.; Velasco-Herrera, Martin Del Castillo; Rodig, Scott J.; Shipp, Margaret A.; Adams, David J.; Pandolfi, Pier Paolo Article ISI CELL (2015)
The BRAF pseudogene functions as a competitive endogenous RNA and induces lymphoma in vivo. Karreth, Florian A; Reschke, Markus; Ruocco, Anna; Ng, Christopher; Chapuy, Bjoern; Léopold, Valentine; Sjoberg, Marcela; Keane, Thomas M; Verma, Akanksha; Ala, Ugo; Tay, Yvonne; Wu, David; Seitzer, Nina; Velasco-Herrera, Martin Del Castillo; Bothmer, Anne; Fung, Jacqueline; Langellotto, Fernanda; Rodig, Scott J; Elemento, Olivier; Shipp, Margaret A; Adams, David J; Chiarle, Roberto; Pandolfi, Pier Paolo Article Cell (2015)
An H3K9/S10 methyl-phospho switch modulates Polycomb and Pol II binding at repressed genes during differentiation Sjoberg, Marcela Article ISI MOLECULAR BIOLOGY OF THE CELL (2014)
An H3K9/S10 methyl-phospho switch modulates Polycomb and Pol II binding at repressed genes during differentiation. Sabbattini, Pierangela; Sjoberg, Marcela; Nikic, Svetlana; Frangini, Alberto; Holmqvist, Per-Henrik; Kunowska, Natalia; Carroll, Tom; Brookes, Emily; Arthur, Simon J; Pombo, Ana; Dillon, Niall Article Molecular biology of the cell (2014)
The Aurora B Kinase and the Polycomb Protein Ring1B Combine to Regulate Active Promoters in Quiescent Lymphocytes Sjoeberg, Marcela; Malumbres, Marcos Article ISI MOLECULAR CELL (2013)
The aurora B kinase and the polycomb protein ring1B combine to regulate active promoters in quiescent lymphocytes. Frangini, Alberto; Sjöberg, Marcela; Roman-Trufero, Monica; Dharmalingam, Gopuraja; Haberle, Vanja; Bartke, Till; Lenhard, Boris; Malumbres, Marcos; Vidal, Miguel; Dillon, Niall Article Molecular cell (2013)
Tau Phosphorylation by cdk5 and Fyn in Response to Amyloid Peptide A beta(25-35): Involvement of Lipid Rafts Hernández P.; Lee G.; Sjoberg, M; Maccioni, RB Article ISI SCOPUS JOURNAL OF ALZHEIMERS DISEASE (2009)
Tau phosphorylation by cdk5 and Fyn in response to amyloid peptide Abeta (25-35): involvement of lipid rafts. Hernandez, Paula; Lee, Gloria; Sjoberg, Marcela; Maccioni, Ricardo B Article Journal of Alzheimer's disease : JAD (2009)
E180splice Mutation in the Growth Hormone Receptor Gene in a Chilean Family with Growth Hormone Insensitivity: A Probable Common Mediterranean Ancestor Espinosa, C; Sjoberg, M; Salazar, T.; Rodriguez, A.; Cassorla, FG; mericq mv; Carvallo, P. Article ISI SCOPUS JOURNAL OF PEDIATRIC ENDOCRINOLOGY & METABOLISM (2008)
E180splice mutation in the growth hormone receptor gene in a Chilean family with growth hormone insensitivity: a probable common Mediterranean ancestor. Espinosa, Claudia; Sjoberg, Marcela; Salazar, Teresa; Rodriguez, Adrian; Cassorla, Fernando G; Mericq, M Veronica; Carvallo, Pilar Article Journal of pediatric endocrinology & metabolism : JPEM (2008)
A novel role for the Aurora B kinase in epigenetic marking of silent chromatin in differentiated postmitotic cells. Sabbattini, Pierangela; Canzonetta, Claudia; Sjoberg, Marcela; Nikic, Svetlana; Georgiou, Andrew; Kemball-Cook, Geoffrey; Auner, Holger W; Dillon, Niall Article The EMBO journal (2007)
Novel role for the Aurora B kinase in epigenetic marking of silent chromatin in differentiated postmitotic cells Canzonetta, Claudia; Sjoberg, Marcela; Georgiou, Andrew; Kemball-Cook, Geoffrey; Auner, Holger W. Article ISI EMBO JOURNAL (2007)
Roles of cholesterol and lipids in the etiopathogenesis of Alzheimer's disease. Rojo, Leonel; Sjöberg, Marcela K; Hernández, Paula; Zambrano, Cristian; Maccioni, Ricardo B Article Journal of biomedicine & biotechnology (2006)
Tau protein binds to pericentromeric DNA: a putative role for nuclear tau in nucleolar organization Sjoberg, MK; Shestakova, E; Mansuroglu, Z; Maccioni, RB; Bonnefoy, E Article ISI SCOPUS JOURNAL OF CELL SCIENCE (2006)
Study of GH sensitivity in Chilean patients with idiopathic short stature Sjoberg, M; Salazar, T.; Espinosa, C; Dagnino, A; Avila, A; Eggers, M; Cassorla F.; Carvallo, P.; mericq mv Article ISI SCOPUS JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2001)


OPA1 GTPase and GE Domain-Specific Mutations Differentially Alter Mitochondrial Fusion Dynamics and Calcium Homeostasis Burte, F; Sjoberg, M; Hajnoczky, G Abstract ISI BIOPHYSICAL JOURNAL (2020)


Revealing the effect of SCFA on the crosstalk between TET enzymes and the glucose sensor OGT that underpins the transcriptional reprogramming for T cell differentiation Alvarez, Carolina Soledad Proyecto (2024)
Project Jaguar: mapping immune cell diversity across Latin America Trinka, Gosia; Sjöberg Herrera, Marcela Katherine Proyecto This project will use single-cell technologies (scATAC-seq, scRNA-seq, CITE-seq) to identify how diverse ancestries impact gene expression and the composition of immune cells. This research will contribute to greater understanding of genetic and environmental influences on immune human traits. (2022)
DNA hydroxymethylation in the T cell lineage: examining the role of the DNA hydroxylase Tet1 and hydroxymethylation in bookmarking key genes for function and development Sjoberg-Herrera, Marcela Katherine Proyecto (2017)
Blueprint Epigenome Project European Union's Seventh Framework Programme (FP7/2007-2013) (Grant agreement n° 282510) Proyecto 2011-2016 Investigador(a)
Estudio de la proteína tau nuclear=> caracterización, análisis del estado de fosforilación, localización y funciones de la proteína en el núcleo celular FONDECYT (403120) Proyecto 2003-2005 Tesista
Instituto Milenio de Estudios Avanzados en Biología Celular y Biotecnología (CBB) MIDEPLAN (NO APLICA) Proyecto 1999-2005 Tesista
Bases moleculares de la insensibilidad a la hormona de crecimiento en pacientes chilenos. FONDEF (1970276) Proyecto 1997-2000 Tesista


Roles of cholesterol and lipids in the etiopathogenesis of Alzheimer's disease Rojo L.; Sjoberg, MK; Hernández P.; Zambrano C.; Maccioni, RB Review ISI SCOPUS JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY (2006)