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Ricardo Benjamin Maccioni Baraona

DIRECTOR

CENTRO INTERNACIONAL DE BIOMEDICINA (ICC)

SANTIAGO, Chile

NEUROSCIENCES; BIOMEDICINE; CELLULAR AND MOLECULAR BIOLOGY; MOLECULAR/CELLULAR STUDIES ON ALZHEIMER´S DISEASE; DEVELOPMENT OF EARLY DIAGNOSIS TOOLS FOR ALZHEIMER'S DISEASE.

Biochemist, UNIVERSIDAD DE CHILE. Chile, 1969
PhD in Biomedical Science, UNIVERSIDAD DE CHILE. Chile, 1975
Postdoctoral fellowship in Neurological science, NATIONAL INSTITUTE OF HEALTH. Estados Unidos, 1976
Postdoctoral fellowship in Neuroscience, UNIVERSITY OF COLORADO HEALTH SCIENCE CENTER. Estados Unidos, 1978

ASISTANT PROFESSOR Full Time

UNIVERSITY OF COLORADO

HEALTH SCIENCE CENTER

Denver, CO, Estados Unidos

1981 - 1985
Associate Professor Full Time

UNIVERSITY OF COLORADO

HEALTH SCIENCE CENTER

Denver, CO, Chile

1986 - 1990
Associate Professor Part Time

UNIVERSITY OF COLORADO

HEALTH SCIENCE CENTER

Denver, CO, Chile

1986 - 1990
Full Professor of Neurology Part Time

UNIVERSIDAD DE CHILE

Medicine

SANTIAGO, Chile

2005 - A la fecha
Full Professor Full Time

UNIVERSIDAD DE CHILE

Science

SANTIAGO, Chile

1990 - A la fecha
DIRECTOR Other

INTERNATIONAL CENTER FOR BIOMEDICINE ICC

NEUROSCIENCE

Santiago, Chile

1990 - A la fecha

Director Part Time

International Center for Biomedicine ICC

Santiago, Chile

1989 - A la fecha
Director Part Time

Millennium Institute for Advanced Studies (CBB)

Santiago, Chile

1999 - 2005
Director Part Time

Mind and Brain Program of the ICC

Santiago, Chile

2006 - A la fecha

One of the major strength in Academic Career has been the Human Capital Training. Participated as tesis Director of 57 graduate students and 30 biochemists and biotechnologists. In addition, directed 18 International courses in the fields of Neuroscience and Cell Biology.

Among the many outreach activities are:
-The organization of over 40 international symposiums and conferences held in Chile, USA and Europe. This includes the Millennium Conference of Dr. Craig Venter in 2003, Santiago - Chile; The EMBO Workshop Symposium in advanced Micrioscopy in Cell Biology, sponsored by EMBO, European Molecular Biology Organization 2003, Santiago - Chile; Scientific Creativity in Alzheimer's Disease 2018, Santiago - Chile; International Conference in Cognitive Neurology 2018, Warsaw - Poland.

-"Workshops series on quality of life for the elderly" 2005-2010, Santiago - Chile, focused on biology of aging and the environmental and nutritional aspects, and style of life for optimal quality of life for the elderly.

- The "Seeds program for education of the high school teachers in science" directed to around 3,000 teachers in the whole country, Chile 2005-2012.

International NIH Postdoctoral Fellowship Award

UNIVERSITY OF COLORADO HEALTH SCIENCES

Estados Unidos, 1975

Postdoctoral Fellowship Award
Senior EMBO Fellow

European Molecular Biology Organization (EMBO)

Alemania, 1984

Senior EMBO Fellow
Presidential Chair in Science

President of Chile

Chile, 1998

An award to distinguish excellence in cutting-edge research in the area of cell biology and biomedicine. Among most important investigator in Chile.
Alzheimer Award

Alzheimer's Association

Estados Unidos, 1999

An award to distinguish outstanding investigation on the molecular basis of Alzheimer's disease and diagnostic tools for these brain disorders.
Tribute to outstanding research in Alzheimer's disease

HARVARD UNIVERSITY

Canada, 2019

Main keynote speaker and plenary lecturer at the conference "2nd International Conference on Dementia & Dementia Care" Toronto, Canada.


Scaling the Andean Shilajit: A Novel Neuroprotective Agent for Alzheimer's Disease Article ISI SCOPUS Pharmaceuticals (2023)
Alzheimer's Disease and Tau Self-Assembly: In the Search of the Missing Link González, Andrea; Kumar Singh, Sandeep Article ISI INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)
Glucose metabolism and AD: evidence for a potential diabetes type 3 González, Andrea; Churruca, Macarena Article ISI Alzheimers Research & Therapy (2022)
Novel Nutraceutical Compounds in Alzheimer Prevention Maccioni, Ricardo Benjamin; González, Andrea; Luettges, Valentina Article ISI BIOMOLECULES (2022)
Biomarkers for Alzheimer's Disease Fuentes, Patricio; Navarrete, Leonardo P. Article ISI SCOPUS CURRENT ALZHEIMER RESEARCH (2019)
CDK5: A Unique CDK and Its Multiple Roles in the Nervous System González, Andrea; Maccioni, Ricardo B Article ISI SCOPUS JOURNAL OF ALZHEIMERS DISEASE (2019)
The Alz-tau Biomarker for Alzheimer's Disease: Study in a Caucasian Population Tapia, Jose; González, Andrea; Maccioni, Ricardo B Article ISI SCOPUS JOURNAL OF ALZHEIMERS DISEASE (2019)
Alzheimer´s Disease in the Perspective of Neuroimmunology Maccioni, Ricardo B; González, Andrea; Andrade, Victor; Cortes, Nicole; Tapia, Jose P. Article ISI Open Neurol J. (2018)
The Natural Product Curcumin as a Potential Coadjuvant in Alzheimer's Treatment Article ISI SCOPUS JOURNAL OF ALZHEIMERS DISEASE (2017)
Neuroinmmunomodulation in neurodegenerative diseases: New scientific evidence [La teoría de la neuroinmunomodulación en enfermedades neurodegenerativas: Nuevas evidencias científicas] Morales I; Arata, L; Maccioni, R. B. Article SCOPUS Revista Chilena de Neuro-Psiquiatria (2015)
Neuroinflammation in the pathogenesis of Alzheimer's disease. A rational framework for the search of novel therapeutic approaches Morales I; Farías G.A.; Maccioni, R. B. Article SCOPUS Frontiers in Cellular Neuroscience (2014)
Tau Oligomers and Fibrils Induce Activation of Microglial Cells Morales I; Jimenez, JM; Mancilla, M; Maccioni, RB Article ISI SCOPUS Journal of Alzheimer's Disease (2013)
Fibrillar Amyloid-beta(1-42) Modifies Actin Organization Affecting the Cofilin Phosphorylation State: A Role for Rac1/cdc42 Effector Proteins and the Slingshot Phosphatase Mendoza-Naranjo, A; Contreras-Vallejos, E; Otth, C; Bamburg, JR; Maccioni, RB; González-Billault, C Article ISI JOURNAL OF ALZHEIMERS DISEASE (2012)
Molecules of the Quinoline Family Block Tau Self-Aggregation: Implications Toward a Therapeutic Approach for Alzheimer's Disease Guzmán, L; San Martín, A; Astudillo Saavedra L.; Maccioni, R. B. Article ISI SCOPUS Journal of Alzheimer's Disease (2012)
Platelet Tau Pattern Correlates with Cognitive Status in Alzheimer's Disease Farías, G; Pérez, P; Maccioni, R. B. Article ISI SCOPUS Journal of Alzheimer's Disease (2012)
Shilajit: A natural phytocomplex with potential procognitive activity Carrasco-Gallardo C.; Guzmán, L; Maccioni, R. B. Article SCOPUS International Journal of Alzheimer's Disease (2012)
Fulvic Acid Inhibits Aggregation and Promotes Disassembly of Tau Fibrils Associated with Alzheimer's Disease Cornejo, A; Jimenez, JM; Caballero, L; Melo, F; Maccioni, RB Article ISI SCOPUS Journal of Alzheimer's Disease (2011)
Human Platelet Tau: A Potential Peripheral Marker for Alzheimer's Disease Neumann K; Farías, G; Slachevsky, A; Pérez, P; Maccioni, RB Article ISI SCOPUS Journal of Alzheimer's Disease (2011)
Mechanisms of tau self-aggregation and neurotoxicity Maccioni, R. B. Article ISI SCOPUS Current alzheimer Research (2011)
Molecular Targets in the Rational Design of AD Specific PET Tracers: Tau or Amyloid Aggregates? Rojo, LE; Gaspar, PA; Maccioni, RB Article ISI CURRENT ALZHEIMER RESEARCH (2011)
Novel Drugs Affecting Tau Behavior in the Treatment of Alzheimer's Disease and Tauopathies Navarrete, LP; Pérez, P; Morales I; Maccioni, RB Article ISI SCOPUS Current alzheimer Research (2011)
IL-3 Control Tau Modifications and Protects Cortical Neurons from Neurodegeneration Zambrano, A; Otth, C; Maccioni, RB Article ISI CURRENT ALZHEIMER RESEARCH (2010)
Neuroimmunomodulation in the Pathogenesis of Alzheimer's Disease Morales I; Farías, G; Maccioni, RB Article ISI SCOPUS NeuroImmunoModulation (2010)
Selective Interaction of Lansoprazole and Astemizole with Tau Polymers: Potential New Clinical Use in Diagnosis of Alzheimer's Disease Rojo, LE; Alzate-Morales, J; Davies, P.; Maccioni, RB Article ISI SCOPUS Journal of Alzheimer's Disease (2010)
CYCLIN-DEPENDENT KINASE 5 ACTIVATOR p35 OVER-EXPRESSION AND AMYLOID BETA SYNERGISM INCREASE APOPTOSIS IN CULTURED NEURONAL CELLS Utreras, E; Maccioni, R; González-Billault, C Article ISI SCOPUS NEUROSCIENCE (2009)
In vivo effects of 3-iodocytisine: Pharmacological and genetic analysis of hypothermia and evaluation of chronic treatment on nicotinic binding sites Zambrano, CA; Marks, MJ; Maccioni, RB Article ISI SCOPUS NEUROPHARMACOLOGY (2009)
Tau Phosphorylation by cdk5 and Fyn in Response to Amyloid Peptide A beta(25-35): Involvement of Lipid Rafts Hernández, P; Lee, G; Sjoberg, M; Maccioni, RB Article ISI SCOPUS JOURNAL OF ALZHEIMERS DISEASE (2009)
The Role of Neuroimmunomodulation in Alzheimer's Disease Maccioni, RB; Rojo, LE; Fernandez, JA; Kuljis, RO Article ISI SCOPUS Annals of the New York Academy of Sciences (2009)
Cognitive impairment and Alzheimer's disease: Links with oxidative stress and cholesterol metabolism Maccioni, R. B.; Rojo L.; Pastene, E; Fuentes, P; Slachevsky, A Article SCOPUS NEUROPSYCHIATRIC DISEASE AND TREATMENT (2008)
Microtubule-associated protein 1B interaction with tubulin tyrosine ligase contributes to the control of microtubule tyrosination Utreras, E; Jimenez-Mateos, EM; Contreras-Vallejos, E; Tortosa E.; Perez, M; Rojas, S; Saragoni, L; Maccioni, RB; Avila, J; González-Billault, C Article ISI SCOPUS DEVELOPMENTAL NEUROSCIENCE (2008)
Mild cognitive impairment and Alzheimer patients display different levels of redox-active CSF iron Lavados M.; Guillon M.; Rojo, LE; Fuentes, P; Maccioni, RB Article ISI SCOPUS JOURNAL OF ALZHEIMERS DISEASE (2008)
The damage signals hypothesis of Alzheimer's disease pathogenesis Fernandez, JA; Rojo L.; Kuljisa, RO; Maccioni, RB Article ISI JOURNAL OF ALZHEIMERS DISEASE (2008)
A beta(1-42) stimulates actin polymerization in hippocampal neurons through Rac1 and Cdc42 Rho GTPases Mendoza-Naranjo, A; González-Billault, C; Maccioni, RB Article ISI SCOPUS JOURNAL OF CELL SCIENCE (2007)
cdk5 Modulates beta- and delta-catenin/Pin1 interactions in neuronal cells Muñoz, JP; Huichalaf, CH; Orellana, D.; Maccioni, RB Article ISI SCOPUS JOURNAL OF CELLULAR BIOCHEMISTRY (2007)
Interleukin-3 prevents neuronal death induced by amyloid peptide Zambrano, A; Otth, C; Mujica, L; Maccioni, RB Article ISI SCOPUS BMC NEUROSCIENCE (2007)
Neuroprotective effect of TNF alpha against the beta-amyloid neurotoxicity mediated by CDK5 kinase Orellana, DI; Quintanilla, RA; Maccioni, RB Article ISI SCOPUS BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH (2007)
Anomalously phosphorylated tau and A beta fragments in the CSF correlates with cognitive impairment in MCI subjects Maccioni, RB; Lavados M.; Guillon M.; Mujica, C; Bosch, R; Farías, G; Fuentes, P Article ISI SCOPUS NEUROBIOLOGY OF AGING (2006)
Production of nerve growth factor by beta-amyloid-stimulated astrocytes induces p75(NTR)-dependent tau hyperphosphorylation in cultured hippocampal neurons Saez, ET; Pehar, M; Vargas, MR; Barbeito, L; Maccioni, RB Article ISI SCOPUS JOURNAL OF NEUROSCIENCE RESEARCH (2006)
Tau protein binds to pericentromeric DNA: a putative role for nuclear tau in nucleolar organization Sjoberg, MK; Shestakova, E; Mansuroglu, Z; Maccioni, RB; Bonnefoy, E Article ISI SCOPUS JOURNAL OF CELL SCIENCE (2006)
ApoE alleles and tau markers in patients with different levels of cognitive impairment Lavados M.; FarÃas G.; Rothhammer, F; Guillon M.; Mujica M.C.; Maccioni C.; Maccioni, R. B. Article ISI SCOPUS ARCHIVES OF MEDICAL RESEARCH (2005)
Role of the JAKs/STATs pathway in the intracellular calcium changes induced by interleukin-6 in hippocampal neurons Article ISI SCOPUS NEUROTOXICITY RESEARCH (2005)
Astrocytic nitric oxide triggers tau hyperphosphorylation in hippocampal neurons Saez, TE; Pehar, M; Vargas, M; Barbeito, L; Maccioni, RB Article ISI SCOPUS IN VIVO (2004)
DIMENSIONES BIOÉTICAS DE LA INVESTIGACIÓN SOBRE EL GENOMA HUMANO Maccioni, Ricardo B; Munoz, Juan P.; Maccioni, Cristóbal Article SCIELO ACTA BIOETHICA (2004)
Effects of natural flavones and flavonols on the kinase activity of Cdk5 Zapata-Torres, G; Opazo, F; Salgado, C; Muñoz, JP; Krautwurst, H; Mascayano, C; Sepulveda-Boza, S; Maccioni, RB Article ISI SCOPUS JOURNAL OF NATURAL PRODUCTS (2004)
Interleukin-6 induces Alzheimer-type phosphorylation of tau protein by deregulating the cdk5/p35 pathway Quintanilla, RA; Orellana, DI; González-Billault, C; Maccioni, RB Article ISI SCOPUS EXPERIMENTAL CELL RESEARCH (2004)
Oxidative stress promotes T dephosphorylation in neuronal cells: The roles of cdk5 and pp1 Zambrano, CA; Egaña, JT; Maccioni, RB; González-Billault, C Article ISI SCOPUS FREE RADICAL BIOLOGY AND MEDICINE (2004)
Iron-activated iron uptake: A positive feedback loop mediated by iron regulatory protein 1 Nunez-Millacura, C; Tapia, V; Muñoz, P; Mazariegos, D; Arredondo, M; Mura, C; Maccioni, RB Article ISI BIOMETALS (2003)
Iron-induced oxidative stress modify tau phosphorylation patterns in hippocampal cell cultures Egaña, JT; Zambrano, C.; González-Billault, C; Maccioni, RB Article ISI BIOMETALS (2003)
Modulation of the JNK and p38 pathways by cdk5 protein kinase in a transgenic mouse model of Alzheimer's disease Otth, C; Mendoza-Naranjo, A; Mujica, L; Zambrano, A; Maccioni, RB Article ISI NEUROREPORT (2003)
New paradigms in the study of the pathogenesis of Alzheimer's disease Nuevos paradigmas en el estudio de la patogénesis de la enfermedad de Alzheimer Maccioni, R; Maccioni C.; Arzola M.E.; Mujica, L Article SCOPUS Revista Chilena de Neuro-Psiquiatria (2003)
Nuevos paradigmas en el estudio de la patogénesis de la enfermedad de Alzheimer Maccioni, Cristóbal; Arzola, María E.; Mujica, Lorena; maccioni, ricardo Article SCIELO Revista chilena de neuro-psiquiatrï¿½a (2003)
Regulation of p27 in the process of neuroblastoma N2A differentiation Muñoz, JP; Sanchez, JR; Maccioni, RB Article ISI SCOPUS JOURNAL OF CELLULAR BIOCHEMISTRY (2003)
An oxidative stress-mediated positive-feedback iron uptake loop in neuronal cells Nunez-Millacura, C; Tapia, V; Muñoz, P; Maccioni, RB Article ISI JOURNAL OF NEUROCHEMISTRY (2002)
Tubulin, actin, and tau protein interactions and the study of their macromolecular assemblies Muñoz, JP; Garrido, J; Maccioni, RB Article ISI SCOPUS JOURNAL OF CELLULAR BIOCHEMISTRY (2002)
A cdk5-p35 stable complex is involved in the beta-amyloid-induced deregulation of cdk5 activity in hippocampal neurons Alvarez, A; Muñoz, JP; Maccioni, RB Article ISI SCOPUS EXPERIMENTAL CELL RESEARCH (2001)
Expression pattern of DMAP-85 during Drosophila embryonic development Cambiazo, V; GonzÃ¡lez M; Maccioni, RB Article ISI SCOPUS MECHANISMS OF DEVELOPMENT (2001)
Differential association of tau with subsets of microtubules containing posttranslationally-modified tubulin variants in neuroblastoma cells Saragoni, L; Hernández, P; Maccioni, RB Article ISI SCOPUS NEUROCHEMICAL RESEARCH (2000)
Increase in the expression of the neuronal cyclin-dependent protein kinase cdk-5 during differentiation of N2A neuroblastoma cells Muñoz, JP; Alvarez, A; Maccioni, RB Article ISI SCOPUS NEUROREPORT (2000)
Nuclear and cytoplasmic tau proteins from human nonneuronal cells share common structural and functional features with brain tau Cross, DC; Muñoz, JP; Hernández, P; Maccioni, RB Article ISI SCOPUS JOURNAL OF CELLULAR BIOCHEMISTRY (2000)


Tau Platelets Biomarker Correlates with Clinical Features of Alzheimer's Disease Slachevsky, A; Delgado, C; Guzmán, L; Reyes, P; Farías, G; Lopez, O; Becker, J; Munoz-Neira, C; Bravo, E; Flores, P; et al. Abstract ISI NEUROLOGY (2013)
Might paretin have effect against tau protein? Cornejo, A; Areche, C; Perez, E; Sepúlveda, B; Maccioni, RB Abstract ISI PLANTA MEDICA (2012)
Tau Oligomers Promote Microglial Activation. The Neuroimmunomodulation Hypothesis of Alzheimer's Disease (AD) Morales I; Jimenez, J; Maccioni, RB Abstract ISI NEUROIMMUNOMODULATION (2011)
DEREGULATION OF p27 PROTEIN IN THE NEUROBLASTOMA N2A Muñoz, JP; Sánchez, J; Maccioni, RB Abstract ISI Anticancer research. (2004)
Phosphorylation dependent control of oxidative modification in Alzheimer disease Liu, Q; Smith, MA; Siedlak, SL; Harris, PL; Maccioni, RB; Sayre, LM; Perry, G Abstract ISI NEUROBIOLOGY OF AGING (2004)
Phosphorylation modulated oxidative modification of neurofilament protein. Liu, Q; Smith, MA; Siedlak, SL; Harris, PL; Maccioni, RB; Sayre, LM; Perry, G Abstract ISI JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY (2004)
A beta PP transgenic mice Tg2576 induces Cdk5-dependent tau hyperphosphorylation Otth, C; Zambrano, A; Arendt, T; Stieler, J; Schliebs, R; González-Billault, C; Maccioni, RB Abstract ISI MOLECULAR BIOLOGY OF THE CELL (2002)
Interleukin-3 promotes neuronal survival in mouse neuroblastoma N2A cells Zambrano, A; Otth, C; Maccioni, RB Abstract ISI MOLECULAR BIOLOGY OF THE CELL (2002)
Interleukin-6 induces Alzheimer's type phosphorylation of tau protein by the cdk5/p35 pathway Quintanilla, RA; Orellana, D.; González-Billault, C; Maccioni, RB Abstract ISI MOLECULAR BIOLOGY OF THE CELL (2002)
Iron and oxidative stress: A positive-feedback iron uptake loop in neuronal cells. Nunez-Millacura, C; Tapia, V; Muñoz, P; Maccioni, RB Abstract ISI FREE RADICAL BIOLOGY AND MEDICINE (2002)
Regulation of brain tau phosphorylation by the CDK5/P35 system under oxidative stress and iron overload conditions Zambrano, C.; Egana, T; González-Billault, C; Maccioni, RB Abstract ISI FREE RADICAL BIOLOGY AND MEDICINE (2002)
Regulation of tau protein by cdk5 during neuritic development Muñoz, JP; Hernandez, PA; Sanchez, JR; Maccioni, RB Abstract ISI MOLECULAR BIOLOGY OF THE CELL (2000)


The Promise for Alzheimer Disease Treatment. Bioactive Compounds Andrade, Victor; Guzman-Martinez, Leonardo; Cortes, Nicole and Macchioni, Ricardo B.; Ghosh, Dilip; Mukherjee, Pulok K. BookSection (2019)
Pore forming neurotoxin-like mechanism for Aβ-induced synaptic failure. Aguayo, Luis; Parodi, Jorge; Sepúlveda, Fernando J.; Opazo, Carlos; Perry, George; maccioni, ricardo BookSection (2009)


Current hypotheses and research milestones in Alzheimer's disease Maccioni, R. B.; Perry, G BookWhole SCOPUS CURRENT HYPOTHESES AND RESEARCH MILESTONES IN ALZHEIMER'S DISEASE (2009)


Central Nervous System Inflammation and Cholesterol Metabolism Alterations in the Pathogenesis of Alzheimer's Disease and Their Diagnostic and Therapeutic Implications Rojo, LE; Fernández, J; Jimenez, J; Maccioni, AA; Sekler, A; Kuljis, RO; Maccioni, RB ConferencePaper ISI SCOPUS CURRENT HYPOTHESES AND RESEARCH MILESTONES IN ALZHEIMER'S DISEASE (2009)
What Have We Learned from the Tau Hypothesis? Maccioni, RB; Rojo, LE; Sekler, MA; Kujis, RO ConferencePaper ISI SCOPUS CURRENT HYPOTHESES AND RESEARCH MILESTONES IN ALZHEIMER'S DISEASE (2009)


Pathway to Tau Modifications and the Origins of Alzheimers Disease EditorialMaterial ISI SCOPUS ARCHIVES OF MEDICAL RESEARCH (2018)
SPECIAL ISSUE Alzheimer Disease Introductory Remarks Maccioni, RB EditorialMaterial ISI ARCHIVES OF MEDICAL RESEARCH (2012)
The Revitalized Tau Hypothesis on Alzheimer's Disease Maccioni, RB; Farías, G; Morales I; Navarrete, L EditorialMaterial ISI SCOPUS Archives of Medical Research (2010)
Regulation of brain tau phosphorylation by the CDK5/P35 complex under oxidative stress conditions Zambrano, C.; Egana, T; González-Billault, C; Maccioni, RB EditorialMaterial ISI BIOMETALS (2003)
Cdk5 Maccioni, RB EditorialMaterial ISI EUROPEAN JOURNAL OF BIOCHEMISTRY (2001)


Opinion on the journal Maccioni, RB Letter ISI ARCHIVES OF MEDICAL RESEARCH (2002)


New compounds derived from piridinmetilsulfinilbenzoxazoles and piridinmetilsulfinibenzotiazoles, radiolabelled or fluorescently and compositions, as specific biomarkers for the diagnosis of neurodegenerative diseases and involved in tau protein diseases. Ricardo Maccioni; Leonel Rojo; Luis Quiñones Sepúlveda Patent (2018)
Innovative blood platelets biomarker for early diagnosis of alzheimer's disease Abstract Ricardo Maccioni; Gonzalo Farias Patent Grant Number: 09012237 (2015)
Method for inhibiting tau protein aggregation and treatment of alzheimer's disease with a compound derived from quinoline Ricardo Maccioni; Leonardo Navarrete; Aurelio San Martin Patent USA Grant Number: 08198300 (2011)
Benzimidazole-derived compounds used as markers in the case of neurodegenerative diseases Ricardo Maccioni Baraona; Leonel Rojo; Rodrigo Kuljis Azocar Patent USA Grant Number: 08916132 (2010)
Nutraceutical composition that comprises extract of shilajit, folic acid, vitamin B12 and vitamin B6 and the use thereof for preventing and/or treating neurodegenerative diseases and/or the cognitive deterioration associated with cerebral ageing. Maccioni, Ricardo Benjamin; Saavedra Ivan; Sandoval, Victor Patent Concedida USA


Escalamiento Nacional del biomarcador Alz-tau® para la detección temprana y apoyo al diagnóstico de la enfermedad de Alzheimer Proyecto (2022)
Nutracéuticos en Alzheimer Proyecto (2022)
Pilot Study for the implementation of a novel Biomarker for early detection and diagnosis of Alzheimer´s Disease in a Hospital of Santiago, Chile and it’s applicability on a routine basis Proyecto (2020)
Advanced clinical trials and molecular composition of the internationally-positioned formula BrainUp-10 Proyecto (2014)
EMPAQUETAMIENTO DEL NUTRACEUTICO BRAIN UP-10 Proyecto (2012)
CELLULAR AND MOLECULAR ASPECTS OF NEUROIMMUNOMODULATION IN THE ALZHEIMER S TYPE NEURONAL DEGENERATION Proyecto (2011)
PROTOTIPO DE KIT DE DIAGNÓSTICO USANDO BIOMARCADOR NO INVASIVO PARA LA DETECCIÓN TEMPRANA DE LA ENFERMEDAD DE ALZHEIMER Proyecto (2010)
Technology transfer of nutraceutical products of economical relevance for Chile Centro Internacional de Biomedicina ICC Proyecto (2010)
Validation of neuropsychological tests and biomarkers for the diagnosis of mild Alzheimer Disease Slachevsky, Andrea Proyecto (2010)
Benzimidazoles as neuroimaging radiotracers for early diagnosis of Alzheimer´s disease Proyecto (2008)
Search for tau binding molecules as radiotracer for neuroimaging of Alzheimer´s disease University of Chile Proyecto (2008)
International Cooperation for Centers of Excellence Centro Internacional de Biomedicina ICC Proyecto (2007)
Biological basis of neurodegenrative disorders: an integrative view of the cellular and molecular signals que control neuron-glia interactions Proyecto (2005)
Design, synthesis and evaluation of possible subtype-selective agonits and allosteric modulators of nicotinic acetylcholine receptors Proyecto (2004)
Millennium Institute for Advanced Studies in Cell Biology and Biotechnology (CBB) Proyecto (2003)
Celullar and molecular basis of neurodegenerative disorders Proyecto (2002)
Studies at the cellular and molecular levels of neuronal differentiation Proyecto (2002)
SEEDS PROJECT FOR IMPROVEMENT OF EDUCATION IN BIOLOGICAL SCIENCES Proyecto (2001)
Regulatory functions of microtubule associated proteins in the cytoskeleton organization Proyecto (1999)
Genesis of paired helical filaments (PHF) in the Alzheimer´s disease Proyecto (1998)
Studies on the regulatory roles of DMAP-85 on the dynamics of microtubules. Moculation by kinases Proyecto (1998)
Roles of microtubule associated protein tau in the regulation of the cytoskeletal filamentous network Proyecto (1997)
Celullar and molecular basis of neurodegenerative disorders: an integrative view from the perspective of the neuronal cytoskeleton Proyecto INTERNATIONAL COOPERATIVE PROJECT (0)


Neuroinflammation as a Common Feature of Neurodegenerative Disorders Maccioni, R. B.; Pastor M.G.; Ramos-Escobar N. Review ISI SCOPUS FRONTIERS IN PHARMACOLOGY (2019)
Behavioral and Neuropsychiatric Disorders in Alzheimers Disease Cortes, N; Andrade, V; Maccioni, RB Review ISI SCOPUS JOURNAL OF ALZHEIMERS DISEASE (2018)
Neuroimmune Tau Mechanisms: Their Role in the Progression of Neuronal Degeneration Cortes, N; Estrella, M Review ISI SCOPUS INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2018)
Nutraceuticals: A Novel Concept in Prevention and Treatment of Alzheimer's Disease and Related Disorders Farías, Gonzalo A.; Guzmán-Martínez, Leonardo; Delgado, Carolina; Maccioni, Ricardo B Review ISI SCOPUS JOURNAL OF ALZHEIMERS DISEASE (2014)
Tau oligomers as potential targets for Alzheimer's diagnosis and novel drugs Guzman-Martinez, L; Maccioni, RB Review ISI FRONTIERS IN NEUROLOGY (2013)
Can Nutraceuticals Prevent Alzheimer's Disease? Potential Therapeutic Role of a Formulation Containing Shilajit and Complex B Vitamins Carrasco-Gallardo C.; Farías G.A.; Fuentes, P; Crespo, F; Maccioni, R. B. Review ISI SCOPUS Archives of Medical Research (2012)
Emerging Noninvasive Biomarkers for Early Detection of Alzheimer's Disease Guzman-Martinez, L; Farías G.A.; Maccioni, R. B. Review ISI SCOPUS Archives of Medical Research (2012)
Insulin Resistance and Alzheimer's Disease: Molecular Links & Clinical Implications Neumann KF; Rojo L.; Navarrete, LP; Farías, G; Reyes, P; Maccioni, RB Review ISI SCOPUS CURRENT ALZHEIMER RESEARCH (2008)
Neuroinflammation: Implications for the pathogenesis and molecular diagnosis of Alzheimer's disease Rojo, LE; Fernandez, JA; Maccioni, AA; Jimenez, JM; Maccioni, RB Review ISI ARCHIVES OF MEDICAL RESEARCH (2008)
Roles of cholesterol and lipids in the etiopathogenesis of Alzheimer's disease Rojo L.; Sjoberg, MK; Hernández, P; Zambrano, C.; Maccioni, RB Review ISI SCOPUS JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY (2006)
The molecular bases of Alzheimer's disease and other neurodegenerative disorders Maccioni, RB; Muñoz, JP; Barbeito, L Review ISI ARCHIVES OF MEDICAL RESEARCH (2001)
The protein kinase Cdk5 - Structural aspects, roles in neurogenesis and involvement in Alzheimer's pathology Maccioni, RB; Otth, C; Muñoz, JP Review ISI EUROPEAN JOURNAL OF BIOCHEMISTRY (2001)

Edgar Pastene

Profesor

Ciencias Básias

Universidad del Bío-Bío

Chillán, Chile

Fernando Crespo

Académico e Investigador

Gestión y Negocios

Universidad Alberto Hurtado

Santiago, Chile

CAROLA OTTH

profesor titular

microbiologia clinica

UNIVERSIDAD AUSTRAL DE CHILE. FACULTAD DE MEDICINA. INSTITUTO DE MICROBIOLOGIA CLINICA

VALDIVIA, Chile

122

Ricardo Maccioni

DIRECTOR

RESEARCH AND DEVELOPMENT

CENTRO INTERNACIONAL DE BIOMEDICINA (ICC)

SANTIAGO, Chile

Gerald Zapata

Profesor Asociado

Química Inorgánica y Analítica

Universidad de Chile

Santiago, Chile

CAROLINA DELGADO

ASSOCIATE PROFESSOR

NEUROLOGÍA y neurocirugía

HOSPITAL CLINICO UNIVERSIDAD DE CHILE

SANTIAGO, Chile

Carolina Mascayano

Académico

Ciencias del Ambiente

UNIVERSIDAD DE SANTIAGO DE CHILE, FACULTAD DE QUÍMICA Y BIOLOGIA

santiago, Chile

Marco Nuñez

Professor

Biology

Fac. Ciencias, Universidad de Chile

Santiago, Chile

AURELIO SAN MARTIN

Profesor Asociado (media jornada)

de Ciencias y Recursos Naturales

FACULTAD DE CIENCIAS

Punta Arenas, Chile

Alberto Cornejo

ICC

Santiago, Chile

Daniel Henriquez

Director Ciencia Transversal

Fundación Centro MERI

Santiago, Chile

Jans Alzate

Associate Professor

Departamento de Bioinformática

UNIVERSIDAD DE TALCA

Talca, Chile

Mauricio Gonzalez

Profesor Titular

INTA

UNIVERSIDAD DE CHILE - INSTITUTO DE NUTRICION Y TECNOLOGIA DE ALIMENTOS

Santiago, Chile

Veronica Cambiazo

Profesora titular

Unidad de Nutrición Básica

UNIVERSIDAD DE CHILE - INTA

Santiago, Chile

Angara Zambrano

Assistant Professor

Biochemistry and Microbiology

UNIVERSIDAD AUSTRAL DE CHILE

Valdivia, Chile

Andrea Slachevsky

Associate Professor

ICBM

UNIVERSIDAD DE CHILE

Chile, Chile

Luis Aguayo

Full Professor

Department of Physiology

Universidad de Concepcion

Concepcion, Chile

Gonzalo Farías

Profesor Asistente

Departamento de Neurología y Neurocirugía Norte y Departamento de Neurociencias

Facultad de Medicina, Universidad de Chile

Santiago, Chile

Rodrigo Kuljis

Founder and President

Office of the President

Zdrav Mozak Limitada

Santiago, Chile

Christian Gonzalez

Full Professor

Biologia

Universidad de Chile

Santiago, Chile

Francisco Melo

FULL PROFESSOR

FISICA

UNIVERSIDAD DE SANTIAGO DE CHILE

SANTIAGO, Chile

Rodrigo Quintanilla

Associate professor

Universidad Autónoma de Chile

Santiago, Chile

Andrea González

Investigadora Asociada

CENTRO INTERNACIONAL DE BIOMEDICINA (ICC)

Santiago, Chile

Jose Egana

Profesor asociado

Instituto de Ingeniería Biológica y Médica

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

Santiago, Chile

Marcela Sjoberg

Assistant professor

Biología Celular y Molecular

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

Santiago, Chile

Pablo Gaspar

Profesor Asociado

Psiquiatria Norte

Universidad de Chile

santiago, Chile

Elias Utreras

Profesor Asistente

Biologia

Universidad de Chile

Santiago, Chile

Felipe Opazo

Group Leader

Center for Biostructural Imaging of Neuodegeneration (BIN)

Göttingen, Alemania

Nicole Cortés

Coordinadora de Estudios Clínicos

Laboratorio de Biología Celular, Molecular y Neurociencias, Corporación Centro Internacional de Biomedicina, ICC

Santiago, Chile

Leonardo Guzman

Investigador Asociado

Diagnóstico

Centro Internacional de Biomedicina ICC

Santiago, Chile

Leonel Rojo

Profesor Asociado

Departamento de Biología

Universidad de Santiago de Chile

Estación Central, Chile

Fernando Crespo

Director

Facultad de Ingeniería, Ciencias y Tecnología

Universidad Bernardo O'Higgins

Santiago, Chile

José Tapia

Ingeniero de Proyectos

Corporación Centro Internacional de Biomedicina

Santiago, Chile

Maria Sekler

Investigadora

Neuroinnovation Ltda

Santiago, Chile

Marcela Mancilla

Docente

Ciencias Básicas

Universidad de Viña del Mar

Viña del Mar, Chile

Karen Neumann

PhD

Producción Animal

Universidad de Chile

Santiago, Chile

Patricio Fuentes

Medico Neurologo

Medicina

Hospital Clínico Universidad de Chile

Santiago, Chile

Francisco Rothhammer

Camila Calfío

Investigador PhD/Jefe de Proyectos

Corp. Centro Internacional de Biomedicina ICC

Santiago, Chile

José Jiménez

Postdoc

Investigación

Fundacion Ciencia y Vida

Santiago, Chile

Leonardo Navarrete

Jefe de Laboratorio

Centro Internacional de Biomedicina

Santiago, Chile

Ricardo Benjamin Maccioni Baraona

Líneas de Investigación

Educación

Biochemist, UNIVERSIDAD DE CHILE. Chile, 1969

PhD in Biomedical Science, UNIVERSIDAD DE CHILE. Chile, 1975

Postdoctoral fellowship in Neurological science, NATIONAL INSTITUTE OF HEALTH. Estados Unidos, 1976

Postdoctoral fellowship in Neuroscience, UNIVERSITY OF COLORADO HEALTH SCIENCE CENTER. Estados Unidos, 1978

Experiencia Académica

ASISTANT PROFESSOR Full Time

Associate Professor Full Time

Associate Professor Part Time

Full Professor of Neurology Part Time

Full Professor Full Time

DIRECTOR Other

Experiencia Profesional

Director Part Time

Director Part Time

Director Part Time

Formación de Capital Humano

Difusión y Transferencia

Premios y Distinciones

International NIH Postdoctoral Fellowship Award

Senior EMBO Fellow

Presidential Chair in Science

Alzheimer Award

Tribute to outstanding research in Alzheimer's disease

Article (59)

Abstract (12)

BookSection (2)

BookWhole (1)

ConferencePaper (2)

EditorialMaterial (5)

Letter (1)

Patent (5)

Proyecto (23)

Review (12)