Man

Rodrigo Arthur Quintanilla Gomez

Associate professor

Universidad Autónoma de Chile

Santiago, Chile

Líneas de Investigación


Neurodegenerative diseases Mitochondria function Confocal microscopy Neuroscience

Educación

  •  Biomedical Sciences, UNIVERSIDAD DE CHILE. Chile, 2005
  •  Biochemistry, UNIVERSIDAD DE CHILE. Chile, 1999

Experiencia Académica

  •   PhD Student Full Time

    UNIVERSIDAD DE CHILE

    Ciencias

    Santiago, Chile

    2000 - 2004

  •   Postdoctoral Associate Full Time

    PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

    Ciencias Biológicas

    Santiago, Chile

    2004 - 2005

  •   Senior Postdoctoral Associate Full Time

    UNIVERSITY OF ROCHESTER

    Rochester, Chile

    2007 - 2009

  •   Postdoctoral Associate Full Time

    UNIVERSITY OF ALABAMA AT BIRMINGHAM

    Birmingham, Chile

    2005 - 2007

  •   Senior Postdoctoral Associate Full Time

    UNIVERSITY OF ROCHESTER

    Rochester, Chile

    2009 - 2010

  •   Research Assistant Professor Full Time

    UNIVERSITY OF ROCHESTER

    Rochester, Chile

    2010 - 2011

  •   Assistant Professor Full Time

    PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

    Medicina

    Santiago, Chile

    2011 - 2013

  •   Associate Professor Full Time

    UNIVERSIDAD AUTONOMA DE CHILE

    Ciencias de la Salud

    Santiago, Chile

    2014 - A la fecha

Experiencia Profesional

  •   Coordinator and Instructor Other

    Millennium Institute for Advanced Studies in Cell Biology (CBB), Faculty of Sciences, Universidad de Chile

    Santiago, Chile

    2002 - 2002

  •   Instructor Other

    EMBO-CBB, Faculty of Sciences, Universidad de Chile

    Santiago, Chile

    2003 - 2003

  •   Instructor Other

    Millennium Institute for Advanced Studies in Cell Biology (CBB), Faculty of Sciences, Universidad de Chile

    Santiago, Chile

    2003 - 2003

  •   Instructor Other

    Confocal Imaging Facility, CRCP Biomedical Center, Fac. Cs Biológicas, PUC

    Santiago, Chile

    2004 - 2005

  •   Adviser Other

    Department of Pathology, University of Rochester Medical Center, Rochester, NY, USA

    Rochester, Estados Unidos

    2009 - 2009

  •   Professor Full Time

    Facultad de Médicina, Pontifícia Universidad Católica de Chile

    Santiago, Chile

    2012 - 2013

  •   Professor Full Time

    Facultad de Ciencias de la Salud, Universidad Autónoma de Chile.

    Santiago, Chile

    2014 - A la fecha

  •   Cell Biology Professor and coordinator Full Time

    Postgraduate Program in Biomedical Sciences, Universidad Autónoma de Chile

    Santiago, Chile

    2014 - A la fecha

Formación de Capital Humano


Tutorial research students since 2011
Graduate:
-2008-2009 Ph. D. Thesis, Ph. D. in Cell Biology, Tory A. Mattews-Roberson, Title: “Caspase-cleaved tau expression results in mitochondrial dysfunction in cortical neurons”, University of Alabama at Birmingham, Birmingham, AL, USA.
-2015-2018 . Pérez M.J., PhD in Biomedical Sciences, Title: "Caracterrización del perfil de disfunción mitocondrial en fibroblastos de pacientes con enfremedad de Alzheimer, Universidad Autónoma de Chile
-2015- 2018. Jara C., PhD in Biomedical Sciences, Title: "Efectos de la proteína tau sobre la disfunción mitocondrial y el deterioro cognitivo en el envejecimiento", Universidad Autónoma de Chile
-2016- 2018. Alarcon Illesca F., Master in Neuroscience, Title: "Estudio de las modificaciones oxidativas presentes en fibroblastos de pacientes con enfermedad de Alzheimer", Universidad Autónoma de Chile
-2016-2018. Marchant-Fuentealba R., Master in Neuroscience, Title: "Análisis genetico de proteínas mitocondriales en pacientes con enfermedad de Alzheimer" Autónoma de Chile.

Undergraduate thesis direction since 2011
-2014-2015 Vergara-Pulgar, K, B.C. Biotechnology, Universidad Santo Tomás, Santiago, Chile
-2015-2016 Vargas A, Kinesiology, UMCE, Santiago, Chile 2016.
-2015-2016 Herrera A, Kinesiology, UMCE, Santiago, Chile
-2015-2016 Molina A, Kinesiology, UMCE, Santiago, Chile
-2017-2018 Loyola R, Kinesiology, UMCE, Santiago, Chile
-2017-2018 Canelo F, Kinesiology, UMCE, Santiago, Chile
-2017-2018 Torres A, Biochemistry, P. Universidad Catolica, Santiago, Chile

Postdoctoral direction since 2011
2016-2018 Dr. Cheril Tapia. Project “Alcohol consumption affects mitochondrial function in the brain”

PhD committee
2016, PhD thesis, Osvaldo Flores, PhD program in Biomedical Sciences, thesis title: “ Neuroinflamación y sistema de melanocortinas en el consumo de alcohol”, Universidad Autónoma, Santiago, Chile.
2017, PhD thesis, Claudia Lucero, PhD program in biomedical Sciences, thesis title: "Rol de la simpatoexcitación en la deslocalización de Cx43 en el cardiomiocito y la arritmogénesis durante la insuficiencia cardiaca crónica", Universidad Autonoma, Santiago, Chile.
2019, PhD thesis, Nicolas Plaza, PhD program in Biomedical Sciences, thesis title: "Caracterización del nuevo efector VPA1328 y su contribución a la inhibición de la vía de señalización NF-kB por Vibrio parahaemolyticus", Universidad Autonoma, Santiago, Chile.
2019, Ph thesis, Rodrigo Mira, PhD program in Cellular and Mollecular Biology, thesis title: "Deterioro de la transmisión sináptica glutamatérgica en trauma cerebral inducido por golpe: Papel de la permeabilidad mitocondrial”, P. Universidad Catolica de Chile, Santiago, Chile.

Courses
-2002 Coordinator and Instructor, International Course: “New advanced co-culture techniques in neuroscience”, Millennium Institute for Advanced Studies in Cell Biology (CBB), Faculty of Sciences, Universidad de Chile, June 2002, Santiago, Chile.
-2003 Instructor, International Course: “Advanced Microscopy in Cell Biology”, EMBO-CBB, Faculty of Sciences, Universidad de Chile, Jan 2003, Santiago, Chile.
-2003 Instructor, “SEMILLA” program, “The Use of Basic Microscopy Techniques for Chilean High School Teachers”, Millennium Institute for Advanced Studies in Cell Biology (CBB), Faculty of Sciences, Universidad de Chile, March 2003, Santiago, Chile.
-2004-2005 Instructor, Confocal Imaging Facility, CRCP Biomedical Center, Fac. Cs Biológicas, PUC, Santiago, Chile.2009 Adviser, Confocal and Imaging Facility, Department of Pathology, University of Rochester Medical Center, Rochester, NY, USA.
-2012-2013 Professor, Program for Ph.D. in Medical Sciences, Course: “La interacción Celular en la Enfermedad: Mecanismos y Funciones”, Facultad de Médicina, Pontifícia Universidad Católica de Chile, Santiago, Chile.
-2014-present Cell Biology Professor, Facultad de Ciencias de la Salud, Universidad Autónoma de Chile.
-2014-present Cell Biology Professor and coordinator, Postgraduate Program in Biomedical Sciences, Universidad Autónoma de Chile.

Ad Hoc Reviewer
Ad hoc reviewer for following journals: Progress in Neurobiology, Acta Neuropathologica, Neurobiology of Aging, Neurobiology of Disease, Journal of Biological Chemistry, Journal of Neurochemistry, Journal of Neuroscience, Free Radical Biology and Medicine, Cellular and Molecular Neurobiology, British Journal of Pharmacology, Neuroscience Letters, Cellular Physiology and Biochemistry, Neurochemistry International and Neuroscience.

Ad hoc reviewer for international grants and postdoctoral fellowships from Alzheimer´s Society, UK, Alzheimer´s Association, USA, and Neurological Foundation of New Zealand, Auckland, New Zealand.

AD-Hoc Committee
-2008 Consultant, Morphology Imaging Core Facility, Department of Pathology, University of Rochester Medical Center, Rochester, New York, USA.
-2009-2014 Editor, ISRN Toxicology, Hindawi Publishing Corporation.
-2014-present Academic Coordinator, Postgraduate Program in Biomedical Sciences, Universidad Autónoma de Chile.

Membership of scientific societies
2006-present Society for Neuroscience, Regular Member;
2014-present Chilean Society for Cell Biology, Regular Member


Difusión y Transferencia


International Meetings since 2011 (*corresponding author)

-J. R. Hom, R. A. Quintanilla, D. L. Hoffman, K. L. Bentley, J. D. Molkentin, S. S. Sheu, G. A. Porter (2011). The embryonic mitochondrial permeability transition pore controls cardiac myocyte mitochondrial maturation and differentiation. 55 Annual Meeting Biophysical Society, Baltimore, MA, March 5-9, 2011, USA.
-R. A. Quintanilla and G. V. W. Johnson (2011). Truncated tau and Ab cooperatively impair mitochondrial biology in cortical neurons. Mitochondrial biology symposium: advances in mitochondrial dynamics and mitochondrial-cytosolic communications, NIH, Bethesda, MA, May 16-17, 2011, USA.
-J. R. Hom, R. Quintanilla, D. L. Hoffman, K. L. Bentley, J. D. Molkentin, S. S. Sheu, G. A. Porter (2011). The permeability transition pore controls cardiac mitochondrial maturation and myocyte differentiation. Mitochondrial biology symposium: advances in mitochondrial dynamics and mitochondrial-cytosolic communications, NIH, Bethesda, MA, May 16-17, 2011, USA.
-S. M. Pritchard, R. A. Quintanilla, and G. V. W. Johnson (2011). Tau may exacerbate mitochondrial dysfunction induced by beta-amyloid or kainic acid. 41th Annual Meeting for Society for Neuroscience, Washington, DC, November 12-16, 2011, USA.
-B. C. Avendaño, S. Contreras-Duarte, R. A. Quintanilla, V. Velarde, J. C. Sáez, and J. A. Orellana (2013). Cx43 hemichannel activity induced by cytokines and high glucose inhibit the glucose transport sensitive to insulin in human endothelial cells. LVI Reunión Anual Sociedad de Biología de Chile, Puerto Varas, Nov 9-14, Chile.
-R. A Quintanilla*, J. A. Godoy, R. von Bernhardi, N. C. Inestrosa, G. V.W. Johnson (2014). Phosphorylated tau potentiates A?-induced mitochondrial damage in mature neurons. XXVIII Reunión Anual Sociedad de Biología Celular de Chile, Puerto Varas, Nov 26-30, Chile.
-R. A. Quintanilla*, K. A. Vergara, F. Cabezas-Opázo (2015). Pathological forms of tau affects mitochondrial dynamics. 45th Annual Meeting for American Society of Neuroscience, Chicago, Oct 17-21, USA.
-C. Jara O., J. A. Godoy, N. C. Inestrosa, G. V.W. Johnson, and R. A. Quintanilla* (2015). Expression of truncated tau affects synaptic function in cultured neurons. XXIX Reunión Anual Sociedad de Biología Celular de Chile, Puerto Varas, Oct 25-30, Chile.
-K. Vergara and R. A. Quintanilla* (2015). Pathological forms of tau affects mitochondrial dynamics in Alzheimer’s disease. XXIX Reunión Anual Sociedad de Biología Celular de Chile, Puerto Varas, Oct 25-30, Chile.
-M. J. Pérez, D. P. Ponce, C. Osorio-Fuentealba, A. Elorza, M. I. Behrens, and R. A. Quintanilla* (2015). Evaluation of mitochondrial function in Alzheimer’s disease fibroblasts. XXIX Reunión Anual Sociedad de Biología Celular de Chile, Puerto Varas, Oct 25-30, Chile.
-M. J. Pérez, D. Ponce, C. Osorio-Fuentealba, M. I. Behrens, and R. A. Quintanilla* (2016). Mitochondrial dysfunction in fibroblasts of patients with sporadic Alzheimer`s disease. International Symposium Biology of Neuropsychiatric Disorders, April 27-29, Valparaiso, Chile.
-C. Jara, M. J. Pérez, K. Vergara, and R. A. Quintanilla* (2016). Tau pathology enhances mitochondrial dynamics impairment induced by A? in Alzheimer´s disease. International Symposium Biology of Neuropsychiatric Disrorders, April 27-29, Valparaiso, Chile.
-M. J. Pérez, D. Ponce, C. Osorio-Fuentealba, M. I. Behrens, and R. A. Quintanilla* (2016). Mitochondrial dysfunction in fibroblasts of patients with sporadic Alzheimer`s disease. Mitochondrial Medicine: Developing new treatments for mitochondrial disease, Wellcome Genome Campus, Hinxton, Cambridge, May 4-6, UK.
-R. A. Quintanilla* (2016). Pathological forms of tau affect mitochondrial function. Implications for the pathogenesis of Alzheimer´s disease. 7th World Congress on Targeting Mitochondria, Oct 24-26, Berlin, Germany.
-Ch. Tapia-Rojas, F. J. Carvajal, R. Mira, W. Cerpa, J. A. Orellana and R. A. Quintanilla* (2016). Adolescent binge-drinking alcohol consumption alters the mitochondrial dynamics and bioenergetics in the hippocampus of adult brain. XXX Reunión Anual Sociedad de Biología Celular de Chile, Puerto Varas, Nov 2-6, Chile.
-M. J. Pérez, D. Ponce, C. Osorio-Fuentealba, M.I. Behrens, R. A. Quintanilla* (2016). Alzheimer`s disease fibroblasts present a characteristic mitochondrial dysfunction profile. XXX Reunión Anual Sociedad de Biología Celular de Chile, Puerto Varas, Nov 2-6, Chile.
-C. Jara, M. J. Pérez, I. Morales , and R. A. Quintanilla (2016). Truncated tau induces mitochondrial dynamics impairment in Alzheimer`s disease. XXX Reunión Anual Sociedad de Biología Celular de Chile, Puerto Varas, Nov 2-6, Chile.
-C. Jara and R. A Quintanilla* (2016). Expression of pathological forms of tau affects synaptic function in cultured neurons. 46 th Annual Meeting for American Society of Neuroscience, San Diego, Nov 12-16, USA.
-M.J Pérez, D. Ponce, M.I. Behrens, R.A. Quintanilla* (2017). Proteolytic Processing of OPA1 is Altered in Fibroblasts Patients with Sporadic Alzheimer´s Disease. International meeting on mitochondrial pathology (EuroMit), Cologne June 11-15, 2017.
-C. Tapia-Rojas, A. Torres, F. Carvajal, R. Mira, C. Arce, W. Cerpa, R. A. Quintanilla* (2017). Adolescent binge alcohol consumption affects hippocampal function through the impairment of mitochondrial dynamics and bioenergetics in the adulthood. 47th Annual Meeting for American Society of Neuroscience, Washington DC, Nov 11-15, USA.
-R. A. Quintanilla*, C. Jara, C. Tapia-Rojas, E. Vergara-Hernandez (2017). Genetic ablation of tau reduces oxidaive damage and improves mitochondrial bioenergetics during the aging. 47th Annual Meeting for American Society of Neuroscience, Washington DC, Nov 11-15, USA.
-M. J. Perez, D. Ponce, M. I. Behrens, R. A. Quintanilla* (2018). Mitochondrial permeability transition pore leads to mitochondrial dysfunction in fibroblasts of patients with Alzheimer´s disease. Cell Symposia Multifaceted Mitochondria, San Diego, Jun 4-6, USA.
-R. A. Quintanilla*, C. Tapia-Rojas, W. Cerpa, J. A. Orellana, E. Karahanian, C. Osorio-Fuentealba (2018). Adolescent binge alcohol consumption affects neuronal communication through the impairment of mitochondrial function in the adulthood. RSA 2018 Annual Meeting, San Diego, Jun 16-20, USA.

Talks and Symposia since 2011:

-2011 Atlantic Health, Department of Neurosciences, title of the presentation: “Truncated tau and Abeta cooperatively impair mitochondria function. Implications for the pathogenesis of Alzheimer’s disease”, Morristown, New Jersey, USA, May 2011.
-2012 Facultad de Médicina, Pontifícia Universidad Católica de Chile, title of the presentation: “Estudio de la función y biología mitocondrial en biomedicina”, Santiago, Chile, October.
-2013 Facultad de Medicina, Pontificia Universidad Católica de Chile, title of the presentation: “Defectos en la proteínas tau y huntingtina afectan la función mitocondrial. Implicancias en la patogénesis de la enfermedad de Alzheimer y Huntington”, Santiago, Chile, December.
-2014 Facultad de Ciencias, Universidad de Chile, title of the presentation: Defectos en la proteína tau afectan la función mitocondrial. Implicancias en la patogénesis de la enfermedad de Alzheimer ”, Santiago, Chile, April.
-2014 Centro de Investigación Biomédica, Universidad Autónoma de Chile, title of the presentation: “ Estudio de la función mitocondrial en enfermedades del envejecimiento”, Santiago, Chile, November.
-2015 Programa Disciplinario de Fisiopatología, ICBM, Facultad de Medicina, Universidad de Chile, title of the presentation: “Formas patológicas de la proteína tau afectan la función mitocondrial. Implicaciones en la patogénesis de la enfermedad de Alzheimer”, Santiago, Chile, August.
-2016 International symposium: Alzheimer´s disease, Challenges and new vistas, Universidad Autonoma de Chile, title of the presentation: “New avenues for diagnostic and treatment against Alzheimer´s disease. The Mitochondrial Approach”, Santiago, Chile, August.
-2016 Seminario Internacional de Políticas Públicas en Alcohol, Universidad Diego Portales, title of presentation:”Nuevas implicancias del sistema de melanocortinas en el consumo de alcohol por atracón en adolescentes”, Santiago, Chile, October.
-2017 Department of Pharmacology and Physiology, University of Rochester, title of the presentation: “Adolescent alcohol consumption impairs brain function through mitochondrial failure”, Rochester, New York, November-
-2018 Congreso del Futuro Maule, Talca, Chile, title of presentation: "Cerebro y energia", Talca, Enero.
-2018 Seminario Actualizaciones en la neurobiologia del alcohol y cannabis, Universidad Autonoma-P. Universidad Catolica, title of the presentation: "Abuso de alcohol en adolescentes. Consecuencias sobre la función y el metabolismo neuronal", Santiago, Chile, Septiembre.
-2018 Seminario Departamento de Biología Celular y Molecular, Facultad de Ciencias, P. Universidad Catolica de Chile, title of the presentation: "Contribución de la proteína tau y la disfunción mitocondrial al deterioro cognitivo presente en el envejecimiento", Santiago, Chile, Octubre.


Premios y Distinciones

  •   PhD Fellowship

    INSTITUTO MILENIO DE ESTUDIOS AVANZADOS EN BIOLOGIA CELULAR Y BIOTECNOLOGIA

    Chile, 2000

    Fellowship to complete graduate students in Biomedical Sciences, Universidad de Chile

  •   Young Latin American Scholars Award

    American Society for Neurochemistry

    Estados Unidos, 2005

    Award to attend to Annual Meeting o fAmerican Society for Neurochemistry, 2005

  •   IBRO TRAVEL AWARD

    IBRO

    Estados Unidos, 2007

    Travel aware for IBRO Neuroscience Meeting, Melbourne, Australia


 

Article (48)

Tau Deletion Prevents Cognitive Impairment and Mitochondrial Dysfunction Age Associated by a Mechanism Dependent on Cyclophilin-D
Alcohol consumption during adolescence alters the hippocampal response to traumatic brain injury
Cardiac remodeling and arrhythmogenesis are ameliorated by administration of Cx43 mimetic peptide Gap27 in heart failure rats
Dietary supplementation of a sulforaphane-enriched broccoli extract protects the heart from acute cardiac stress
Stimulation of Melanocortin Receptor-4 (MC4R) Prevents Mitochondrial Damage Induced by Binge Ethanol Protocol in Adolescent Rat Hippocampus
Adolescence binge alcohol consumption induces hippocampal mitochondrial impairment that persists during the adulthood
Connexin 43 hemichannels and pannexin-1 channels contribute to the alpha-synuclein-induced dysfunction and death of astrocytes
Connexin 43 hemichannels and pannexin-1 channels contribute to the α-synuclein-induced dysfunction and death of astrocytes
Adolescent Binge Alcohol Exposure Affects the Brain Function Through Mitochondrial Impairment
Adolescent Binge Alcohol Exposure Affects the Brain Function Through Mitochondrial Impairment (vol 55, pg 4473, 2018)
Adolescent Binge Alcohol Exposure Affects the Brain Function Through Mitochondrial Impairment.
Caspase-Cleaved Tau Impairs Mitochondrial Dynamics in Alzheimers Disease
Contribution of Tau Pathology to Mitochondrial Impairment in Neurodegeneration
Genetic ablation of tau improves mitochondrial function and cognitive abilities in the hippocampus
Heavy Alcohol Exposure Activates Astroglial Hemichannels and Pannexons in the Hippocampus of Adolescent Rats: Effects on Neuroinflammation and Astrocyte Arborization
Mitochondrial permeability transition pore contributes to mitochondrial dysfunction in fibroblasts of patients with sporadic Alzheimers disease
Revisiting the physiological effects of exercise training on autonomic regulation and chemoreflex control in heart failure: does ejection fraction matter?
Ventilatory and Autonomic Regulation in Sleep Apnea Syndrome: A Potential Protective Role for Erythropoietin?
Adolescent Binge Alcohol Exposure Affects the Brain Function Through Mitochondrial Impairment
Caspase-Cleaved Tau Impairs Mitochondrial Dynamics in Alzheimer’s Disease
Development or disease: duality of the mitochondrial permeability transition pore
Mitochondrial Bioenergetics Is Altered in Fibroblasts from Patients with Sporadic Alzheimer's Disease
New Implications for the Melanocortin System in Alcohol Drinking Behavior in Adolescents: The Glial Dysfunction Hypothesis
Quercetin Exerts Differential Neuroprotective Effects Against H2O2 and A beta Aggregates in Hippocampal Neurons: the Role of Mitochondria
Neuron-Glia crosstalk in the autonomic nervous system and its possible role in the progression of metabolic syndrome: A new hypothesis
Quercetin Affects Erythropoiesis and Heart Mitochondrial Function in Mice
Phosphorylated tau potentiates A beta-induced mitochondrial damage in mature neurons
Mitochondrial permeability transition pore induces mitochondria injury in Huntington disease
Thiazolidinediones Promote Axonal Growth through the Activation of the JNK Pathway
Truncated tau and Abeta cooperatively impair mitochondria in primary neurons.
Bioenergetics, mitochondria, and cardiac myocyte differentiation.
The permeability transition pore controls cardiac mitochondrial maturation and myocyte differentiation.
Amyloid-beta-Acetylcholinesterase complexes potentiate neurodegenerative changes induced by the A beta peptide. Implications for the pathogenesis of Alzheimer's disease
Caspase-cleaved tau expression induces mitochondrial dysfunction in immortalized cortical neurons: implications for the pathogenesis of Alzheimer disease.
Role of mitochondrial dysfunction in the pathogenesis of Huntington's disease.
Immortalized cortical neurons expressing caspase-cleaved tau are sensitized to endoplasmic reticulum stress induced cell death.
Rosiglitazone treatment prevents mitochondrial dysfunction in mutant huntingtin-expressing cells - Possible role of peroxisome proliferator-activated receptor-gamma (PPAR gamma) in the pathogenesis of Huntington disease
Mitochondrial-targeted active Akt protects SH-SY5Y neuroblastoma cells from staurosporine-induced apoptotic cell death.
Neuroprotective effect of TNF alpha against the beta-amyloid neurotoxicity mediated by CDK5 kinase
Peroxisome proliferator-activated receptor gamma up-regulates the Bcl-2 anti-apoptotic protein in neurons and induces mitochondrial stabilization and protection against oxidative stress and apoptosis
Type 2 transglutaminase differentially modulates striatal cell death in the presence of wild type or mutant huntingtin.
Mutant huntingtin expression induces mitochondrial calcium handling defects in clonal striatal cells: Functional consequences
Peroxisomal proliferation protects from beta-amyloid neurodegeneration
Peroxisome proliferator-activated receptor gamma is expressed in hippocampal neurons and its activation prevents beta-amyloid neurodegeneration: role of Wnt signaling
Role of the JAKs/STATs pathway in the intracellular calcium changes induced by interleukin-6 in hippocampal neurons
Trolox and 17beta-estradiol protect against amyloid beta-peptide neurotoxicity by a mechanism that involves modulation of the Wnt signaling pathway.
Interleukin-6 induces Alzheimer-type phosphorylation of tau protein by deregulating the cdk5/p35 pathway
Cytosolic [Ca2+] modulates basal GLUT1 activity and plays a permissive role in its activation by metabolic stress and insulin in rat epithelial cells

Abstract (2)

Peroxisomal proliferation prevents beta-amyloid-neurotoxicity in rat hippocampal neurons
Interleukin-6 induces Alzheimer's type phosphorylation of tau protein by the cdk5/p35 pathway

BookSection (3)

Alcohol consumption affects neuronal function: Role of the mitochondria
Chapter 13: Stimulation of tau degradation
Chapter 14. New targets for diagnostic and treatment against Alzheimer`s disease. The mitochondrial approach

ConferencePaper (1)

Peroxisomal proliferation prevents beta-amyloid neurodegeneration

Proyecto (18)

CONTRIBUTION OF THE MITOCHONDRIAL PERMEABILITY TRANSITION PORE TO THE BIOENERGETICS FAILURE AND COGNITIVE IMPAIRMENT INDUCED BY TRUNCATED TAU IN ALZHEIMER´S DISEASE
Role and regulation of mitochondrial function in abnormal synaptic transmission induced by traumatic brain injury
Role and regulation of mitochopndrial function in abnormal synaptic transmission induced by traumatic brain injury
Truncated tau by caspase 3 induces synaptic dysfunction and cognitive failure through the impairment of mitochondrial dynamics. Implications for the pathogenesis of Alzheimer´s disease
TRUNCATED TAU BY CASPASE 3 INDUCES SYNAPTIC DYSFUNCTION AND COGNITIVE FAILURE THROUGH THE IMPAIRMENT OF MITOCHONDRIAL DYNAMICS. IMPLICATIONS FOR THE PATHOGENESIS OF ALZHEIMER´S DISEASE.
Centro de investigación para el estudio cae la conducta del consumo de alcohol en adolescentes: De la molécula a la función cerebral y el metabolismo periférico
Centro de Investigación para el estudio de la conducta del consumo de alcohol en adolescentes=> De la molécula a la función cerebral y el metabolismo periférico
Uncovering the role of hemichannels by alpha-synuclein
UNCOVERING THE ROLE OF HEMICHANNELS IN GLIAL AND NEURONAL DYSFUNCTION INDUCED BY ALPHA-SYNUCLEIN
Pathological forms of tau impairs mitochondrial function in Alzheimer's disease
PATHOLOGICAL FORMS OF TAU IMPAIRS MITOCHONDRIAL FUNCTION IN ALZHEIMER´S DISEASE
PARTICIPATION OF SCAVENGER RECEPTOR A IN THE INFLAMMATORY ACTIVATION OF GLIAL CELLS=> A POTENTIAL TARGET FOR THERAPEUTIC INTERVENTION IN ALZHEIMERS DISEASE.
Understanding the role of mitochondrial dysfunction and Aβ in the pathogenesis of Alzheimer’s disease
Understanding the role of tau and Abeta in the pathogenesis of Azlheimer's disease"
Pilot funding=> “Improving Mitochondrial Health in Alzheimer’s disease”
ESTUDIO LONGITUDINAL DE TAU, AB ( 1-42 ) Y DEL GENOTIPO APO-E4 COMO MARCADORES DIAGNOSTICOS EN PACIENTES CON DEMENCIA CUESTIONABLE Y CON ENFERMEDAD DE ALZHEIMER
MECANISMOS MOLECULARES DE LA INHIBICION DE LA QUINASA ERK POR EL CININOGENO
Improving Mitochondrial Health in Alzheimer’s disease

Review (10)

Effect of Alcohol on Hippocampal-Dependent Plasticity and Behavior: Role of Glutamatergic Synaptic Transmission
Alcohol impairs hippocampal function: From NMDA receptor synaptic transmission to mitochondrial function
It's all about tau
Alcohol consumption during adolescence: A link between mitochondrial damage and ethanol brain intoxication
Possible role of mitochondrial permeability transition pore in the pathogenesis of Huntington disease
Mitochondrial Dysfunction Contributes to the Pathogenesis of Alzheimer's Disease
Therapeutic Actions of the Thiazolidinediones in Alzheimer's Disease
Role of PPAR gamma in the Differentiation and Function of Neurons
Understanding Risk Factors for Alzheimer's Disease: Interplay of Neuroinflammation, Connexin-based Communication and Oxidative Stress
Trolox and 17 beta-estradiol protect against amyloid beta-peptide neurotoxicity by a mechanism that involves modulation of the Wnt signaling pathway
64
Rodrigo Quintanilla

Associate professor

Universidad Autónoma de Chile

Santiago, Chile

11
Waldo Cerpa

Profesor Asociado

Biología Celular y Molecular

Pontificia Universidad Catolica de Chile

Santiago, Chile

8
Nibaldo Inestrosa

Full Professor

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

8
Cheril Tapia

Profesor Asistente

Facultad de Medicina y Ciencia

Universidad San Sebastián

Santiago, Chile

8
Juan Orellana

Associate Professor

Departamento de Neurología

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

6
Juan Godoy

Tecnologo Medico

Laboratorio Clinico Cruz del Sur

Santiago, Chile

5
Rodrigo Del Rio

Assistant Professor

Physiology

Pontificia Universidad Católica de Chile

Santiago, Chile

4
Rommy von Bernhardi

Full Professor

Neurology

DEPT. NEUROLOGY, FAC. MEDICINE PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

3
David Andrade

Profesor Asistente

Biomedico

Universidad de Antofagasta

Antofagasta, Chile

3
Ricardo Maccioni

DIRECTOR

RESEARCH AND DEVELOPMENT

CENTRO INTERNACIONAL DE BIOMEDICINA (ICC)

SANTIAGO, Chile

3
Hugo Diaz

PhD

Fisiología

Pontificia Universidad Católica de Chile

Santiago, Chile

2
Maria Behrens

Profesor Titular

Neurología y Neurocirugía, y de Neurociencia

Hospital Clínico Universidad de Chile

Santiago, Chile

2
Christian Gonzalez

Full Professor

Biology

Universidad de Chile

Santiago, Chile

2
Daniela Ponce

Coordinadora de investigación

Universidad de Chile

Santiago, Chile

2
Nicole Salgado

Coordinador tecnico

Facultad de Ciencias Biologicas

Pontificia Universidad Católica de Chile

Santiago, Chile

2
Francisco Carvajal

asistente de investigacion

Universidad de Magallanes

punta arenas, Chile

2
Juan Oyarzún

Investigador postdoctoral

Pontificia Universidad Católica de Chile

Santiago, Chile

2
Karen Fuenzalida

Encargado de confirmación diagnóstica de Errores Innatos del Metabolismo (EIM) mediante técnicas GCMS y LCMSMS

Instituto de Nutrición y Tecnología de Alimentos

Universidad de Chile

Santiago, Chile

1
ANDREA MAHN

Profesor Titular

Ingeniería Química

UNIVERSIDAD DE SANTIAGO DE CHILE

Santiago, Chile

1
Rodrigo Fuentealba

Postdoctoral Research Associate

Departamento de Inmunología Clínica y Reumatología / Facultad de Medicina

Pontificia Universidad Católica

Santiago, Chile

1
Eduardo Karahanian

Professor

INSTITUTO DE CIENCIAS BIOMEDICAS

UNIVERSIDAD AUTONOMA DE CHILE

Santiago, Chile

1
Celia Salazar

Postdoctorado

Universidad Autónoma de Chile

Talca, Chile

1
Luis Barros

Principal Research

Laboratorio Biología Molecular

CENTRO DE ESTUDIOS CIENTÍFICOS

Valdivia, Chile

1
Elias Utreras

Profesor Asistente

Biologia

Universidad de Chile

Santiago, Chile

1
Mauricio Retamal

Associate Professor

Centro de Fisiología Celular e Integrativa

Universidad del Desarrollo

Santiago, Chile

1
César Osorio

Associate Professor

Kinesiología

Universidad Metropolitana de Ciencias de la Educación

Santiago, Chile

1
Alvaro Elorza

ASSOCIATE PROFESSOR

INSTITUTE OF BIOMEDICAL SCIENCES

UNIVERSIDAD ANDRES BELLO

Santiago, Chile

1
William Tiznado

Full professor

Chemical Sciences

UNIVERSIDAD ANDRES BELLO

Santiago, Chile

1
Rodrigo Iturriaga

Chairman of the Department of Physiology

Physiology

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

Santiago, Chile

1
Marlén Barreto

Profesor asociado

UNIVERSIDAD AUTONOMA DE CHILE

Santiago de Chile, Chile

1
Ivan Alfaro

Associate Professor, Director of Innovation and Technology Development

Faculty of Medicine

Universidad del Desarrollo

Santiago, Chile

1
Gonzalo Olivares

ASSISTANT PROFESSOR

NEUROCIENCIA

Universidad de Chile

SANTIAGO, Chile

1
Daniela Rebolledo

Académico

Centro de Excelencia en Biomedicina de Magallanes

Punta Arenas, Chile

1
Omar Porras

Assistant professor

Lab. Biología Celular

UNIVERSIDAD DE CHILE

Santiago, Chile

1
Patricio Ramos

academico

Instituto de ciencias biológicas

UNIVERSIDAD DE TALCA

Talca, Chile