Waldo_cebima.jpg_thumb90

Waldo Francisco Cerpa Nebott

Profesor Asociado

Pontificia Universidad Catolica de Chile

Santiago, Chile

Líneas de Investigación


To study biology of glutamatergic receptors including distribution, properties and modulation, with emphasis in events related to synaptic plasticity in physiological and pathological conditions including neurodegenerative conditions.

Educación

  •  Ciencias Biologicas, PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE. Chile, 2009
  •  Bioquímico, PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE. Chile, 2004

Experiencia Académica

  •   Post doctoral fellow Full Time

    UNIVERSITY OF WASHINGTON-SEATTLE

    Seattle, Estados Unidos

    2010 - 2013

  •   Assistant professor Full Time

    PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

    Ciencias Biologicas

    Santiago, Chile

    2013 - 2018

  •   Associate Professor Full Time

    PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

    Ciencias Biológicas

    Santiago, Chile

    2019 - A la fecha

Experiencia Profesional

  •   director departamento de biologia celular y molecular Part Time

    Pontificia Universidad Catolica de Chile

    santiago, Chile

    2018 - 2019

  •   sub director Part Time

    Centro de Excelencia en biomedicina de Magallanes (CEBIMA)

    Punta Arenas, Chile

    2019 - A la fecha

Formación de Capital Humano


Francisco Carvajal, PhD Student, Biological Science, Biología Celular y Molecular, Pontificia Universidad Catolica de Chile
Matias Lira, PhD Student, Biological Science, Biología Celular y Molecular, Pontificia Universidad Catolica de Chile
Rodrigo Mira, undergraduate Student, Biochemistry, Pontificia Universidad Catolica de Chile
Camila Arce, undergraduate Student, Biochemistry, Pontificia Universidad Catolica de Chile
Eugenio Diaz Urbina, undergraduate Student, Biochemistry, Pontificia Universidad Catolica de Chile
Patricio Orrego, postdoctoral research, grant BMBF20150065
Rodrigo Mira, PhD Student, Biological Science, Biología Celular y Molecular, Pontificia Universidad Catolica de Chile
Constanza Caceres, undergraduate Student, Biochemistry, Pontificia Universidad Catolica de Chile


Difusión y Transferencia


Charla “Como estudiar el cerebro” colegio José Agustín Alfonso (SIP), Pedro Aguirre Cerda. Septiembre 2014
Participación en Feria Científica Colegio Rosa Elvira Matte de Prieto (SIP), Lo Espejo. Charla “Como estudiar el cerebro” y jurado feria. Octubre 2015
Participación proyecto “el próximo puedes ser tu”, Colegio Rosa Elvira Matte de Prieto (SIP), Octubre 2016
Participación como jurado en Encuentro Científico – Tecnológico Interescolar de la Sociedad de Instrucción Primaria (SIP). Noviembre 2016.
Comentario: Una memoria prodigiosa es la clave de los genios del ajedrez. Cuerpo A el mercurio, 30 de noviembre 2016.
Charla "Nuestro Cerebro: efecto del alcohol", Colegio San Agustín, el Bosque, 28 de Junio 2017
Participación en panel de expertos en 10 actividades (2018 a 2019) del plan de difusión de la corte de Apelaciones de San Miguel Tema: Drogas y Delitos, información y riesgos.
Entrevista televisiva en canal Mega Plus, programa Vanguardia, 26 de Marzo 2019 Tema: Trauma cerebral inducido por golpe en futbolistas
Entrevista radial en radio pauta, programa la invención del futuro, 28 de Marzo 2019, Tema: Trauma cerebral inducido por golpe en futbolistas
Invitado a entrevista televisiva en canal Fox Sport, programa Fox sport radio, 11 de abril 2019, Tema: Trauma cerebral inducido por golpe en futbolistas
Entrevista en los medios escritos en relación al Tema: Trauma cerebral inducido por golpe en futbolistas
Las ultimas noticias, 20 de Marzo 2019
El mostrador, 25 de Marzo 2019
El dia,24 de Marzo 2019
CHV Noticias, 24 de Marzo 2019
El mercurio de Valparaiso, 25 de Marzo 2019
AlAirelibre.cl (deportes cooperativa), 24 de Marzo 2019
El espectador (Colombia),24 de Marzo 2019
Hoy (Los Angeles, USA), 24 de Marzo 2019
montevideo portal (Uruguay), 24 de Marzo 2019
el diario de yucatan (Mexico), 25 de Marzo 2019
Noticias 24 (venezuela), 24 de Marzo 2019
Univision (USA), 24 de Marzo 2019
Acento (Santo Domingo) , 24 de Marzo 2019
Sin embargo (México), 24 de Marzo 2019
2001.com (Venezuela), 24 de Marzo 2019
el nacional (Venezuela), 27 de Marzo 2019

Generación de la aplicación movil de Trivia, ¿Quien quiere ser nobel?, para estudiantes de bioquímica de la pontificia Universidad Católica de Chile


Premios y Distinciones

  •   Scopus-Elsevier Award

    Scopus-Elsevier

    Chile, 2013

    Scopus-Elsevier Award, Scientific production, Young scientist (2013)

  •   64th Lindau Nobel Laureate Meeting

    64th Lindau Nobel Laureate Fundation

    Alemania, 2014

    Selected to participates in 64th Lindau Nobel Laureate Meeting, Germany (2014)


 

Article (42)

Exo70 intracellular redistribution after repeated mild traumatic brain injury
Tau Deletion Prevents Cognitive Impairment and Mitochondrial Dysfunction Age Associated by a Mechanism Dependent on Cyclophilin-D
Alcohol consumption during adolescence alters the hippocampal response to traumatic brain injury
Building a Bridge Between NMDAR-Mediated Excitotoxicity and Mitochondrial Dysfunction in Chronic and Acute Diseases
Glutamatergic Receptor Trafficking and Delivery: Role of the Exocyst Complex
Neuronal surface P antigen (NSPA) modulates postsynaptic NMDAR stability through ubiquitination of tyrosine phosphatase PTPMEG
Stimulation of Melanocortin Receptor-4 (MC4R) Prevents Mitochondrial Damage Induced by Binge Ethanol Protocol in Adolescent Rat Hippocampus
Adolescent Binge Alcohol Exposure Affects the Brain Function Through Mitochondrial Impairment (vol 55, pg 4473, 2018)
Adolescent Binge Alcohol Exposure Affects the Brain Function Through Mitochondrial Impairment.
Age-related NMDA signaling alterations in SOD2 deficient mice
Amyloid-beta oligomers synaptotoxicity: The emerging role of EphA4/c-Abl signaling in Alzheimers disease
Genetic ablation of tau improves mitochondrial function and cognitive abilities in the hippocampus
Heavy Alcohol Exposure Activates Astroglial Hemichannels and Pannexons in the Hippocampus of Adolescent Rats: Effects on Neuroinflammation and Astrocyte Arborization
The inhibition of CTGF/CCN2 activity improves muscle and locomotor function in a murine ALS model.
Adolescent Binge Alcohol Exposure Affects the Brain Function Through Mitochondrial Impairment
New Implications for the Melanocortin System in Alcohol Drinking Behavior in Adolescents: The Glial Dysfunction Hypothesis
Quercetin Exerts Differential Neuroprotective Effects Against H2O2 and A beta Aggregates in Hippocampal Neurons: the Role of Mitochondria
Modulation of the NMDA Receptor Through Secreted Soluble Factors
Role of NMDA Receptor-Mediated Glutamatergic Signaling in Chronic and Acute Neuropathologies
RoR2 functions as a noncanonical Wnt receptor that regulates NMDAR-mediated synaptic transmission
Wnt5a inhibits K+ currents in hippocampal synapses through nitric oxide production
Andrographolide reduces cognitive impairment in young and mature A beta PPswe/PS-1 mice
Wnt-5 alpha increases NO and modulates NMDA receptor in rat hippocampal neurons
Regulation of NMDA-Receptor Synaptic Transmission by Wnt Signaling
Amyloid-beta Peptide Fibrils Induce Nitro-Oxidative Stress in Neuronal Cells
The Hyperforin Derivative IDN5706 Occludes Spatial Memory Impairments and Neuropathological Changes in a Double Transgenic Alzheimer's Mouse Model
Wnt Signaling Modulates Pre- and Postsynaptic Maturation: Therapeutic Considerations
Wnt-5a occludes A beta oligomer-induced depression of glutamatergic transmission in hippocampal neurons
Overexpression of amyloid precursor protein increases copper content in HEK293 cells
THE ROLE OF WNT SIGNALING IN NEUROPROTECTION
Wnt-5a/JNK Signaling Promotes the Clustering of PSD-95 in Hippocampal Neurons
beta-amyloid oligomers affect the structure and function of the postsynaptic region: Role of the Wnt signaling pathway
Release of acetylcholinesterase (AChE) from beta-amyloid plaques assemblies improves the spatial memory impairments in APP-transgenic mice
Structure-function implications in Alzheimer s disease: Effect of a oligomers A beta central synapses
Wnt-7a modulates the synaptic vesicle cycle and synaptic transmission in hippocampal neurons
Hyperforin prevents beta-amyloid neurotoxicity and spatial memory impairments by disaggregation of Alzheimer's amyloid-beta-deposits
Copper brain homeostasis: role of amyloid precursor protein and prion protein
Human-like rodent amyloid-beta-peptide determines Alzheimer pathology in aged wild-type Octodon degu
Is there a role for copper in neurodegenerative diseases?
Acetylcholinesterase-A beta complexes are more toxic than A beta fibrils in rat hippocampus - Effect on rat beta-amyloid aggregation, laminin expression, reactive astrocytosis, and neuronal cell loss
The N-terminal copper-binding domain of the amyloid precursor protein protects against Cu2+ neurotoxicity in vivo
THE N-TERMINAL COPPER-BINDING DOMAIN OF THE AMYLOID PRECURSOR PROTEIN PROTECTS AGAINST Cu2+ NEUROTOXICITY IN VIVO

Proyecto (8)

Role of Mitochondrial oxidative stress in abnormal synaptic transmission induced by traumatic brain Injury=> a look from the perspective of the tripartite synapse
Truncated tau by caspase 3 induces synaptic dysfunction and cognitive failure through the impairment of mitochondrial dynamics. Implications for the pathogenesis of Alzheimer´s disease
C-ABL IS A KEY CELLULAR AND SYNAPTIC HOMEOSTASIS REGULATOR. ITS DYSREGULATION IS INVOLVED IN EARLY ALZHEIMER DISEASE PATHOLOGY
Centro de Investigación para el estudio de la conducta del consumo de alcohol en adolescentes=> De la molécula a la función cerebral y el metabolismo periférico
Neuroplastin goes presynaptic ­ implications for endo­/exocytosis and the exocyst complex
PARTICIPATION OF NMDA RECEPTORS DISTRIBUTION IN OXIDATIVE STRESS=> ROLE OF BALANCE BETWEEN SYNAPTIC PLASTICITY AND SYNAPTOTOXICITY
PARTICIPATION OF NMDA RECEPTORS DISTRIBUTION IN OXIDATIVE STRESS=> ROLE OF BALANCE BETWEEN SYNAPTIC PLASTICITY AND SYNAPTOTOXICITY
Regulation of NMDA-receptor synaptic transmission by Wnt signaling

Review (6)

Effect of Alcohol on Hippocampal-Dependent Plasticity and Behavior: Role of Glutamatergic Synaptic Transmission
Alcohol impairs hippocampal function: From NMDA receptor synaptic transmission to mitochondrial function
Wnt Signaling Modulates Pre- and Postsynaptic Maturation: Therapeutic Considerations
Structure-function implications in Alzheimer's disease: Effect of a oligomers A beta central synapses
Copper brain homeostasis: Role of amyloid precursor protein and prion protein
Is there a role for copper in neurodegenerative diseases?
43
Waldo Cerpa

Profesor Asociado

Biología Celular y Molecular

Pontificia Universidad Catolica de Chile

Santiago, Chile

20
Nibaldo Inestrosa

Full Professor

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

11
Rodrigo Quintanilla

Associate professor

Universidad Autónoma de Chile

Santiago, Chile

6
Juan Godoy

Tecnologo Medico

Laboratorio Clinico Cruz del Sur

Santiago, Chile

5
Lorena Varela

Assistant Professor

Biological Sciences

Universidad Andres Bello

Santiago, Chile

5
Cheril Tapia

Profesor Asistente

Facultad de Medicina y Ciencia

Universidad San Sebastián

Santiago, Chile

5
Ivan Alfaro

Associate Professor, Director of Innovation and Technology Development

Faculty of Medicine

Universidad del Desarrollo

Santiago, Chile

5
Francisco Carvajal

asistente de investigacion

Universidad de Magallanes

punta arenas, Chile

5
Juan Orellana

Associate Professor

Departamento de Neurología

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

4
DOMINGO BONANSCO

Profesor Titular

Instituto de Fisiologia

UNIVERSIDAD DE VALPARAISO, FACULTAD DE CIENCIAS

Valparaiso, Chile

4
Matías Lira

Postdoc

Universidad San Sebastián

Santiago, Chile

3
Marco Fuenzalida

Full Professor

Physiology

UNIVERSIDAD DE VALPARAÍSO

Valparaíso, Chile

2
Ariel Reyes

Director de Departamento

Ciencias Biológicas

UNIVERSIDAD ANDRÉS BELLO

Santiago, Chile

2
Christian Hodar

ASSISTANT PROFESSOR

BIOINFORMATICS & GENEXPRESSION LAB - INTA

UNIVERSIDAD DE CHILE

Santiago, Chile

2
Veronica Cambiazo

Profesora titular

Unidad de Nutrición Básica

UNIVERSIDAD DE CHILE - INTA

Santiago, Chile

2
PEDRO ZAMORANO

Profesor Asociado

Depto Biomédico

Universidad de Antofagasta

Antofagasta, Chile

2
Alicia Nogueras

Profesor Asociado Adjunto

Departamento de Biología Celular y Molecular

P. UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

2
Marcelo Chacon

Postdoc

Neurology

UTHealth

Houston, Estados Unidos

1
Aldo Villalon

Director Académico/Profesor Asistente

Ciencias de la Salud

Universidad de Aysén

Coyhaique, Chile

1
Nicole Salgado

Coordinador

Facultad de Ciencias Biologicas

Pontificia Universidad Católica de Chile

Santiago, Chile

1
MANUEL VARAS

Research Professor

UNIVERSIDAD SAN SEBASTIÁN

Santiago, Chile

1
Juan Oyarzún

Investigador postdoctoral

Pontificia Universidad Católica de Chile

Santiago, Chile

1
Inge Wyneken

Full Professor

Medicina

UNIVERSIDAD DE LOS ANDES

Santiago, Chile

1
Eduardo Karahanian

Professor

INSTITUTO DE CIENCIAS BIOMEDICAS

UNIVERSIDAD AUTONOMA DE CHILE

Santiago, Chile

1
Rodrigo Fuentealba

Postdoctoral Research Associate

Departamento de Inmunología Clínica y Reumatología / Facultad de Medicina

Pontificia Universidad Católica

Santiago, Chile

1
Genevieve Merabachvili

Profesor Asistente

salud

Universidad Santo Tomás

Santiago, Chile

1
Jorge Parodi

Director de laboratorio

Universidad Mayor de Chile

Temuco, Chile

1
David Rovegno

PROFESOR ASISTENTE ADJUNTO

Medicina Intensiva

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

Santiago, Chile

1
Luis González

Full Professor

School of Medicine

Universidad San Sebastián

Santiago, Chile

1
Alejandra Alvarez

Full professor

Cell and Molecular Biology

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE, FACULTAD DE CIENCIAS BIOLÓGICAS

Santiago, Chile

1
Alejandro Rojas

Assistant Professor

UNIVERSIDAD AUSTRAL DE CHILE

Valdivia, Chile

1
Mauricio Gonzalez

Profesor Titular

INTA

UNIVERSIDAD DE CHILE - INSTITUTO DE NUTRICION Y TECNOLOGIA DE ALIMENTOS

Santiago, Chile

1
Daniela Rebolledo

Académico

Centro de Excelencia en Biomedicina de Magallanes

Punta Arenas, Chile

1
Fabián Segovia

Assistant professor

Department of Cell Biology

Universidad de Concepción

Concepción, Chile

1
María Barake

Becaria Postdoctoral

Facultad de Medicina y ciencia

Universidad San Sebastián

Santiago, Chile

1
Francisco Aboitiz

Profesor

Psychiatry

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

santiago, Chile

1
Francisco Bozinovic

Full professor

Ecology

Pontifical Catholic University of Chile

Santiago, Chile

1
Rebeca Aldunate

Profesor Titular

Ciencias

UNIVERSIDAD SANTO TOMÁS

Santiago, Chile

1
Juan Montiel

Profesor Titular

FACULTAD DE MEDICINA

UNIVERSIDAD DIEGO PORTALES

Santiago, Chile