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DOMINGO CHRISTIAN BONANSCO HERRERA

Profesor Titular

UNIVERSIDAD DE VALPARAISO, FACULTAD DE CIENCIAS

Valparaiso, Chile

Líneas de Investigación


Synaptic Plasticity; Learning and Memory; Astroglial Modulation of Synaptic Plasticity mediated by Gliotransmitters ; Electrophysiology of synaptic transmission in neurological and neurodegenerative diseases.

Educación

  •  Neurobiologia y Cs. de la Conducta, UNIVERSIDAD DE CHILE. Chile, 1993
  •  Neurociencia Celular y Molecular, Universidad Complutense, Insto. Cajal CSIC. España, 1998
  •  Licenciado en Biologia, UNIVERSIDAD DE CHILE. Chile, 1986

Experiencia Académica

  •   Assistant Profesor Full Time

    UNIVERSIDAD DE PLAYA ANCHA DE CIENCIAS DE LA EDUCACION

    Sciences

    Valparaiso, Chile

    1988 - 2000

  •   Full professor Full Time

    UNIVERSIDAD DE VALPARAISO

    Sciences

    Valparaiso, Chile

    2000 - A la fecha

Experiencia Profesional

  •   Director and Full Professor Full Time

    Universidad de Valparaiso, Facultad de Ciencias; Instituto de Fisiologia

    Valparaiso, Chile

    2000 - A la fecha

  •   Assistant Professor Full Time

    U. de PLaya Ancha, Fac. Ciencias, Depto. Biología

    Valparaiso, Chile

    1988 - 2000

Formación de Capital Humano


ALTERACIONES EN LA EXCITABILIDAD NEURONAL Y ASTROGLIAL EN RATAS EPILÉPTICAS MODIFICAN LA PLASTICIDAD SINÁPTICA, JUAN CARLOS MORALES, PROGRAMA DE DOCTORADO EN CIENCIAS, MENCIÓN NEUROCIENCIA, FACULTAD DE CIENCIAS, U. VALPARAÍSO, 2013. (Director, EN CURSO).

PAPEL DE LA ASTROGLIA EN LA EPILEPTOGÉNESIS, CARLA ALVARES FERRADAS, PROGRAMA DE DOCTORADO EN CIENCIAS, MENCIÓN NEUROCIENCIA, FACULTAD DE CIENCIAS, U. VALPARAÍSO, 2012. (Director, EN CURSO).

SEÑALIZACIÓN ASTROCITO–ASTROCITO Y PLASTICIDAD SINÁPTICA, MARIO WELLMANN, PROGRAMA DE MAGÍSTER EN CIENCIAS, MENCIÓN NEUROCIENCIA, FACULTAD DE CIENCIAS, U. VALPARAÍSO, 2012. (Director, EN CURSO).

"EFECTOS DE WNT-5a EN LA NEUROTRANSMISIÓN GABAÉRGICA EN UN MODELO MURINO DE DISTROFIA MUSCULAR DE DUCHENNE, CLAUDIA ESPINOZA MARTINEZ, MAGISTER CS. BIOLÓGICAS M/ NEUROCIENCIA, FAC. CIENCIAS U. VALPARAÍSO, 2011 (Co-Director)

“Participación de la vía Wnt en transducción de señales de la función sináptica y su papel en la enfermedad de Alzheimer”, Waldo Cerpa, PROGRAMA DE DOCTORADO EN CIENCIAS, MENCIÓN BIOLOGÍA CELULAR Y MOLECULAR, FACULTAD DE CIENCIAS BIOLÓGICAS, PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE, 2009. (Co-Director).

“Modulación de la actividad sináptica gabaérgica por coactivación de receptores para endocanabinodes y acetilcolina en el hipocampo”, Alejandro Couve, PROGRAMA DE MAGÍSTER EN CIENCIAS, MENCIÓN NEUROCIENCIA, FACULTAD DE CIENCIAS, U. VALPARAÍSO, 2010. (Co-Director).

“Efectos de la Gliotoxina Fluorocitrato sobre la transmisión sináptica CA3-CA1 en Hipocampo”, Juan Cristian Rojas, MAGISTER CS. BIOLÓGICAS M/ NEUROCIENCIA, FAC. CIENCIAS U. VALPARAÍSO, 2010 (Director).

“Maduración de las Propiedades de Excitabilidad y Eficacia Sinaptica en las Respuestas Reflejas en Médula Espinal Aislada del Mutante taiep”, Marco Fuenzalida Nuñez, MAGISTER CS. BIOLÓGICAS M/ NEUROCIENCIA, FAC. CIENCIAS U. VALPARAÍSO, 2002 (Director).


Premios y Distinciones

  •   EMINENT SCIENTIST OF THE YEAR 2008 FOR SOUTH AMERICA

    World Scientists Forum of the International Research Promotion Council (IRPC)

    Chile, 2008

    Neurology and Neurobiology area


 

Article (41)

Gliotransmission: A Novel Target for the Development of Antiseizure Drugs
Programming of Dopaminergic Neurons by Early Exposure to Sex Hormones=> Effects on Morphine-Induced Accumbens Dopamine Release, Reward, and Locomotor Behavior in Male and Female Rats
Astroglial Ca 2+ -dependent hyperexcitability requires p2y 1 purinergic receptors and pannexin-1 channel activation in a chronic model of epilepsy
Astroglial Ca 2+ -dependent hyperexcitability requires p2y 1 purinergic receptors and pannexin-1 channel activation in a chronic model of epilepsy
Neonatal exposure to oestradiol increases dopaminergic transmission in nucleus accumbens and morphine-induced conditioned place preference in adult female rats
SVCT2 Expression and Function in Reactive Astrocytes Is a Common Event in Different Brain Pathologies
Plasticity of Hippocampal Excitatory-Inhibitory Balance: Missing the Synaptic Control in the Epileptic Brain.
Enhanced astroglial Ca2+ signaling increases excitatory synaptic strength in the epileptic brain.
A new rapid kindling variant for induction of cortical epileptogenesis in freely moving rats
A new rapid kindling variant for induction of cortical epileptogenesis in freely moving rats
Glutamate released spontaneously from astrocytes sets the threshold for synaptic plasticity
HYPEREXCITABLE ASTROCYTES INCREASE THE PROBABILITY OF GLUTAMATE RELEASE AT CA3-CA1 SYNAPSES IN SLICES FROM KINDLED EPILEPTIC RATS
HYPEREXCITABLE ASTROCYTES INCREASE THE PROBABILITY OF GLUTAMATE RELEASE AT CA3-CA1 SYNAPSES IN SLICES FROM KINDLED EPILEPTIC RATS
Wnt-5a Modulates Recycling of Functional GABA(A) Receptors on Hippocampal Neurons
Wnt-5a Modulates Recycling of Functional GABA(A) Receptors on Hippocampal Neurons
Wnt-5a occludes A beta oligomer-induced depression of glutamatergic transmission in hippocampal neurons
Wnt-5a occludes A beta oligomer-induced depression of glutamatergic transmission in hippocampal neurons
CHANGES OF RELEASE PROPERTIES ON CA3-CA1 SYNAPSES INDUCED BY METABOLIC ARREST OF ASTROCYTES IN HIPPOCAMPAL SLICES
Developmental Increase of Asynchronic Glutamate Release From Hippocampal Synapses in Mutant taiep Rat
Developmental Increase of Asynchronic Glutamate Release From Hippocampal Synapses in Mutant taiep Rat
Developmental Increase of Asynchronic Glutamate Release From Hippocampal Synapses in Mutant taiep Rat
Wnt-5a/JNK Signaling Promotes the Clustering of PSD-95 in Hippocampal Neurons
beta-amyloid oligomers affect the structure and function of the postsynaptic region: Role of the Wnt signaling pathway
beta-amyloid oligomers affect the structure and function of the postsynaptic region: Role of the Wnt signaling pathway
beta-amyloid oligomers affect the structure and function of the postsynaptic region=> Role of the Wnt signaling pathway
Wnt-7a modulates the synaptic vesicle cycle and synaptic transmission in hippocampal neurons
Asynchronic transmission in the CA3-CA1 hippocampal synapses in the neurological mutant taiep rat
Developmental impairment of compound action potential in the optic nerve of myelin mutant taiep rats
Developmental impairment of compound action potential in the optic nerve of myelin mutant taiep rats
Altered synaptic and electrical properties of lumbar motoneurons in the neurological glial mutant taiep rat
Altered synaptic and electrical properties of lumbar motoneurons in the neurological glial mutant taiep rat
Immature developmental pattern of the monosynaptic reflex in isolated spinal cord of glial mutant taiep rats
Immature developmental pattern of the monosynaptic reflex in isolated spinal cord of glial mutant taiep rats
Asynchronous excitatory post synaptic currents evoked in hippocampal CA1 pyramidal cells of the glial mutant taiep rat
Cellular mechanisms underlying the rhythmic bursts induced by NMDA microiontophoresis at the apical dendrites of CA1 pyramidal neurons
Synaptic and electrical properties of lumbar motoneurons in the glial mutant Taiep rat along the neonatal period
Tetanic stimulation of schaffer collaterals induces rhythmic bursts via NMDA receptor activation in rat CA1 pyramidal neurons
Voltage-clamp analysis of the potentiation of the slow Ca2+-activated K+ current in hippocampal pyramidal neurons
The activity-dependent potentiation of the slow Ca2+-activated K+ current regulates synaptic efficacy in rat CA1 pyramidal neurons
Ionic components of the electrical response of chromaffin cells from the toad (Caudiverbera caudiverbera) adrenal gland.
IONIC COMPONENTS OF THE ELECTRICAL RESPONSE OF CHROMAFFIN CELLS FROM THE TOAD (CAUDIVERBERA-CAUDIVERBERA) ADRENAL-GLAND

Abstract (4)

CHANGES OF RELEASE PROPERTIES ON CA3-CA1 SYNAPSES INDUCED BY METABOLIC ARREST OF ASTROCYTES IN HIPPOCAMPAL SLICES
Asynchronous excitatory post synaptic currents evoked in hippocampal CA1 pyramidal cells of the glial mutant taiep rat
Myelin mutant taiep rat show an alteration in the spinal cord (SC) monosynaptic responses
Synaptic and electrical properties of lumbar motoneurons in the glial mutant Taiep rat along the neonatal period

ConferencePaper (1)

?-amyloid oligomers affect the structure and function of the postsynaptic region: Role of the Wnt signaling pathway

Proyecto (8)

GABAergic neurotransmission is critical for controlling the prefrontal cortex spike timing dependent plasticity in schizophrenia
NEONATAL PROGRAMMING=> SEX HORMONES EXCESS DISRUPTS MIDBRAIN DOPAMINE FUNCTION IN THE ADULTHOOD.
REGULATION OF LONG-TERM PLASTICITY AT INHIBITORY CIRCUITS BY ACETYLCHOLINE=> NEW ROLE OF PARVALBUMIN-POSITIVE INTERNEURONS IN THE HIPPOCAMPAL FUNCTION AND MEMORY
THE ROLE OF ASTROGLIAL EXCITABILITY ON THE MODULATION OF SYNAPTIC PLASTICITY DURING THE PROGRESSION OF HIPPOCAMPAL EPILEPSY
ROLE OF MTOR PATHWAY AND L-BDNF TRANSCRIPT IN THE VALPROATE MODEL OF AUTISM
CONTRIBUTION OF GLUTAMATE RELEASED BY ASTROCYTES TO HIPPOCAMPAL EPILEPTOGENESIS
MODULACION PRESINAPTICA MEDIADA POR ASTROCITOS EN NEURONAS PIRAMIDALES DE CA1 DEL HIPOCAMPO.
NEUROBIOLOGIA DEL MUTANTE MIELINICO TAIEP.ALTERACIONES EN LA INTERACCION NEURONA-GLIA DURANTE EL DESARROLLO Y SUS EFECTOS SOBRE LA EXCITABILIDAD DE TRACTOS Y SINAPSIS CENTRALES

Review (1)

Priming of GABAergic Long-term Potentiation by Muscarinic Receptors
28
DOMINGO BONANSCO

Profesor Titular

Instituto de Fisiologia

UNIVERSIDAD DE VALPARAISO, FACULTAD DE CIENCIAS

Valparaiso, Chile

18
Marco Fuenzalida

Full Professor

Physiology

UNIVERSIDAD DE VALPARAÍSO

Valparaíso, Chile

5
Nibaldo Inestrosa

Full Professor

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

4
Juan Godoy

Tecnologo Medico

Laboratorio Clinico Cruz del Sur

Santiago, Chile

4
Ivan Alfaro

Associate Professor, Director of Innovation and Technology Development

Faculty of Medicine

Universidad del Desarrollo

Santiago, Chile

4
Waldo Cerpa

Profesor Asociado

Biología Celular y Molecular

Pontificia Universidad Catolica de Chile

Santiago, Chile

4
Andrés Couve

Profesor Titular

Neurociencia

FACULTAD DE MEDICINA, UNIVERSIDAD DE CHILE

Santiago, Chile

2
Ramón Sotomayor

Full Professor

Institute of Physiology

UNIVERSIDAD DE VALPARAÍSO, FACULTAD DE CIENCIAS, DEPARTAMENTO DE FISIOLOGÍA

Valparaíso, Chile

2
Virginia Olivares

profesor auxiliar

fonoaudiologia / audiologia

universidad de valparaiso

Vina del mar, Chile

1
Pablo Roncagliolo

Director

Universidad de Valparaíso

Valparaíso, Chile

1
Maria Andres

Full Professor

Cellular and Molecular Biology

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

1
Rodrigo Fuentealba

Postdoctoral Research Associate

Departamento de Inmunología Clínica y Reumatología / Facultad de Medicina

Pontificia Universidad Católica

Santiago, Chile

1
Esteban Aliaga

Profesor

Kinesiología

Universidad Católica el Maule

Talca, Chile

1
FRANCISCO NUALART

Full Professor and Scientific Director

Cellular Biology and Center for Advanced Microscopy CMA BIO-BIO

UNIVERSIDAD DE CONCEPCION

Concepcion, Chile

1
Jonathan Martínez

Profesor ayudante

UNIVERSIDAD DE VALPARAISO

Valparasiso, Chile

1
Pablo Moya

Full Professor

Physiology

Universidad de Valparaiso

Valparaiso, Chile

1
Juan Saez

Professor

Instituto de Neurociencias

Universidad de Valparaiso

Valparaíso, Chile

1
Loreto Cuitiño

Investigador Asociado

Oftalmología

Hospital Clínico Universidad de Chile

229788866, Chile