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Andrés Oscar Couve Correa

Profesor Titular

FACULTAD DE MEDICINA, UNIVERSIDAD DE CHILE

Santiago, Chile

Líneas de Investigación


Non-conventional mechanisms of local trafficking in dendrites and axons of central and peripheral neurons in mammals. Local trafficking in Drosophila axons. Neurosystems and technological applications. Value and societal impact of science.

Educación

  •  Cell Biology, MOUNT SINAI MEDICAL CENTER. Estados Unidos, 1997
  •  Cell Biology, PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE. Chile, 1991

Experiencia Académica

  •   Profesor Titular Full Time

    UNIVERSIDAD DE CHILE

    Medicina

    Santiago, Chile

    2012 - A la fecha

  •   Profesor Asociado Full Time

    UNIVERSIDAD DE CHILE

    Medicina

    Santiago, Chile

    2009 - 2012

  •   Assistant Professor Full Time

    UNIVERSIDAD DE CHILE

    Medicina

    Santiago, Chile

    2005 - 2009

  •   Investigador Full Time

    CENTRO DE ESTUDIOS CIENTIFICOS DE SANTIAGO

    Valdivia, Chile

    2004 - 2005

Experiencia Profesional

  •   Director Other

    Instituto Milenio de Neurociencia Biomédica (BNI)

    Santiago, Chile

    2011 - A la fecha

Formación de Capital Humano


Graduate training

2017: Science and society workshop at the Center for Interdisciplinary Research (CRI). The value of science, Paris, France.
2010-2016: Ph.D Program in Biomedicine Committee. Faculty of Medicine, Universidad de Chile.
2006-2012: Master in Cell Biology Committee. Faculty of Medicine, Universidad de Chile.

Supervision Postdoctoral Fellows

2016-present: Alejandro Luarte
2016-present: Víctor Hugo Cornejo
2016-present: Carolina González
2015-2016: José Cánovas
2011-2012: Viviana Valdés
2010-2013: Omar Ramírez

Supervision Ph.D. Students

2016-present: Supervisor, Ph.D. Thesis, Javiera Gallardo, Universidad de Chile, expected completion: 2019
2016-present: Supervisor, Ph.D. Thesis, Nataly Venegas, Universidad de Chile, expected completion: 2019
2016-present: Supervisor, Ph.D. Thesis, Francisca Bertín, Universidad de Chile, expected completion: 2018
2012-2016: Supervisor, Ph.D. Thesis, María de los Ángeles Juricic, Universidad de Chile, expected completion: October 2016
2012-2016: Supervisor, Ph.D. Thesis, Jorge Toledo, Universidad de Chile, expected completion: August 2016
2012-2016: Supervisor, Ph.D. Thesis, Daniela Salas, Universidad de Chile
2012-2016: Supervisor, Ph.D. Thesis, Cristian de Gregorio, Universidad de Chile
2011-2015: Supervisor, Ph.D. Thesis, Carolina Gonzalez, Universidad de Chile
2010-2014: Supervisor, Ph.D. Thesis, José Ignacio Valenzuela, Universidad de Chile
2009-2010: Supervisor, Ph.D. Thesis, Juan Manuel Rodríguez, Universidad de Chile
2008-2015: Supervisor, Ph.D. Thesis, Felipe Salech, MD, Universidad de Chile
2008-2012: Co-supervisor, Ph.D. Thesis, Oscar Lazo, Pontificia Universidad Católica de Chile
2006-2010: Supervisor, Ph.D. Thesis, Karina Vargas, Universidad Austral de Chile
2005-2009: Supervisor, Ph.D. Thesis, Omar Ramírez, Universidad de Chile
2004-2008: Supervisor, Ph.D. Thesis, René Vidal, Universidad Austral de Chile
1999-2002: Co-supervisor, Ph.D. Thesis, Benjamin Fairfax, Ph.D., University College London

Supervision Masters Students

2016-present: Supervisor Masters in Neuroscience Thesis, Renate Reisenegger, expected completion: 2017
2014-2015: Supervisor Masters in Neuroscience Thesis, Ignacio Herrera
2012-2014: Supervisor Masters in Neuroscience Thesis, Javiera Fresno
2010-2012: Supervisor, Masters Thesis, Consuelo Arias, Universidad de Chile

Supervision Undergraduate Students

2014-2017: Supervisor, Biochemistry Undergraduate Thesis, Macarena Díaz, Universidad de Chile, expected completion: 2016
2010-2013: Supervisor, Biochemistry Undergraduate Thesis, Antaris Varela, Universidad Católica de Valparaíso
2010-2012: Supervisor, Biochemistry Undergraduate Thesis, Matías Jaureguiberry, Universidad Andrés Bello
2006-2008: Supervisor, Biochemistry Undergraduate Thesis, José Valenzuela, Universidad de Chile
2006-2008: Supervisor, Biochemistry Undergraduate Thesis, Constanza Morales, Universidad de Chile
2005-2006: Supervisor, Biochemistry Undergraduate Thesis, Roger Koenig-Robert, Universidad de Chile
2004-2006: Supervisor, Biochemistry Undergraduate Thesis, Lisette Sandoval, Universidad Austral de Chile


Difusión y Transferencia


2018-present: Vice-President Fundación Puerto de Ideas
2016-present: Director Fundación Vive-Chile VTR
2015-2017: President Sociedad de Biología Celular de Chile
2015: Presidential Committee for the Development of Science, Technology and Innovation
2007-2009: Fondecyt Study Section Biology 2, Conicyt


Premios y Distinciones

  •   Andrés Couve

    Premio Andrés Concha, SOFOFA

    Chile, 2017

    Construcción de puentes entre ciencia e industria

  •   Andrés Couve

    Saint George's College

    Chile, 2016

    80th anniversary award in science


 

Article (48)

Golgi bypass for local delivery of axonal proteins, fact or fiction?
The axonal endoplasmic reticulum: One organelle-many functions in development, maintenance, and plasticity.
Drosophila Atlastin in motor neurons is required for locomotion and presynaptic function
Local Klotho Enhances Neuronal Progenitor Proliferation in the Adult Hippocampus
Axons provide the secretory machinery for trafficking of voltage-gated sodium channels in peripheral nerve
Axons provide the secretory machinery for trafficking of voltage-gated sodium channels in peripheral nerve.
Frizzled-1 receptor regulates adult hippocampal neurogenesis
Frizzled-1 receptor regulates adult hippocampal neurogenesis.
A RhoA Signaling Pathway Regulates Dendritic Golgi Outpost Formation
A RhoA Signaling Pathway Regulates Dendritic Golgi Outpost Formation.
Combining eye tracking and pupillary dilation analysis to identify Website Key Objects
Combining eye tracking and pupillary dilation analysis to identify Website Key Objects
Preface. Trafficking of organelles and proteins in the nervous system.
RESETing ER proteostasis: selective stress pathway hidden in the secretory route
The Axonal Endoplasmic Reticulum and Protein Trafficking: Cellular Bootlegging South of the Soma
Transport along the dendritic endoplasmic reticulum defines the trafficking modality for GABAB receptors
Transport along the dendritic endoplasmic reticulum mediates the trafficking of GABA(B) receptors
BDNF Regulates Rab11-Mediated Recycling Endosome Dynamics to Induce Dendritic Branching
BDNF regulates Rab11-mediated recycling endosome dynamics to induce dendritic branching.
Endoplasmic Reticulum Sorting and Kinesin-1 Command the Targeting of Axonal GABA(B) Receptors
Endoplasmic reticulum sorting and kinesin-1 command the targeting of axonal GABAB receptors
RNA interference of Marlin-1/Jakmip1 results in abnormal morphogenesis and migration of cortical pyramidal neurons
RNA interference of Marlin-1/Jakmip1 results in abnormal morphogenesis and migration of cortical pyramidal neurons
Converging pathways in the occurrence of endoplasmic reticulum (er) stress in Huntington s disease
Glutamate released spontaneously from astrocytes sets the threshold for synaptic plasticity
Location matters: the endoplasmic reticulum and protein trafficking in dendrites
Location matters: the endoplasmic reticulum and protein trafficking in dendrites
Neuronal protein trafficking: emerging consequences of ER dynamics
The endoplasmic reticulum and protein trafficking in dendrites and axons
Confined displacement algorithm determines true and random colocalization in fluorescence microscopy
Prolonged activation of NMDA receptors promotes dephosphorylation and alters postendocytic sorting of GABA(B) receptors
Role of AMPA and NMDA Receptors and Back-Propagating Action Potentials in Spike Timing-Dependent Plasticity
Wnt-5a Modulates Recycling of Functional GABA(A) Receptors on Hippocampal Neurons
Cellular and subcellular localization of Marlin-1 in the brain
Deficits in spatial memory correlate with modified ?-aminobutyric acid type A receptor tyrosine phosphorylation in the hippocampus
Deficits in spatial memory correlate with modified gamma-aminobutyric acid type A receptor tyrosine phosphorylation in the hippocampus
Dendritic assembly of heteromeric ?-aminobutyric acid type B receptor subunits in hippocampal neurons
Dendritic Assembly of Heteromeric gamma-Aminobutyric Acid Type B Receptor Subunits in Hippocampal Neurons
Marlin-1 is expressed in testis and associates to the cytoskeleton and GABA B receptors
Marlin-1 is expressed ion testis and associates to the cytoskeleton and GABA(B) receptors
The Availability of Surface GABA(B) Receptors Is Independent of gamma-Aminobutyric Acid but Controlled by Glutamate in Central Neurons
The availability of surface GABAB receptors is independent of ?-aminobutyric acid but controlled by glutamate in central neurons
Marlin-1 and conventional kinesin link GABA(B) receptors to the cytoskeleton and regulate receptor transport
Marlin-1 and conventional kinesin link GABAB receptors to the cytoskeleton and regulate receptor transport
Multiple motifs regulate the trafficking of GABA(B) receptors at distinct checkpoints within the secretory pathway
Marlin-1, A Novel RNA-binding Protein Associates with GABAB Receptors
Phosphorylation and Chronic Agonist Treatment Atypically Modulate GABA B Receptor Cell Surface Stability
Unravelling the unusual signalling properties of the GABA(B) receptor

Abstract (2)

The Dendritic Endoplasmic Reticulum and Conventional Kinesin Define a Non Canonical Trafficking Modality for GABAB Receptors
Effect of poly(ADP-ribose) polymerase-1 (PARP-1) inhibition on metabolic insults occurring at birth: promises and limitations

EditorialMaterial (2)

Preface
RESETing ER proteostasis: selective stress pathway hidden in the secretory route

Letter (1)

Reply to Meredith and Groen: Role of AMPA and NMDA Receptors and Back-Propagating Action Potentials in Spike Timing-Dependent Plasticity

Review (5)

Global and local mechanisms sustain axonal proteostasis of transmembrane proteins
The axonal endoplasmic reticulum and protein trafficking: Cellular bootlegging south of the soma
Converging Pathways in the Occurrence of Endoplasmic Reticulum (ER) Stress in Huntington's Disease
Neuronal protein trafficking: Emerging consequences of endoplasmic reticulum dynamics
The endoplasmic reticulum and protein trafficking in dendrites and axons
55
Andrés Couve

Profesor Titular

Neurociencia

FACULTAD DE MEDICINA, UNIVERSIDAD DE CHILE

Santiago, Chile

9
Marco Fuenzalida

Full Professor

Physiology

UNIVERSIDAD DE VALPARAÍSO

Valparaíso, Chile

6
Steffen Härtel

Full Professor

Instituto de Ciencias Biomédicas

University of Chile

Santiago, Chile

6
JOSÉ VALENZUELA

INSTITUT CURIE

PARIS, Francia

5
Matias Jaureguiberry

Head of Science and Product Development

Cellter

Santiago, Chile

3
DOMINGO BONANSCO

Profesor Titular

Instituto de Fisiologia

UNIVERSIDAD DE VALPARAISO, FACULTAD DE CIENCIAS

Valparaiso, Chile

2
Nibaldo Inestrosa

Full Professor

PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE

Santiago, Chile

2
René Vidal

Profesor Asistente

Universidad Mayor

Santiago, Chile

2
Felipe Salech

Academic

Medicine

Universidad de Chile / Facultad de Medicina

Santiago, Chile

1
Juan Godoy

Tecnologo Medico

Laboratorio Clinico Cruz del Sur

Santiago, Chile

1
Maria Behrens

Profesor Titular

Neurología y Neurocirugía, y de Neurociencia

Hospital Clínico Universidad de Chile

Santiago, Chile

1
Ricardo Delgado

Profesor Adjunto

Biología

UNIVERSIDAD DE CHILE, FACULTAD DE CIENCIAS, DEPARTAMENTO DE BIOLOGIA

Santiago, Chile

1
Pedro Maldonado

Profesor Titular

Departamento de Neurociencias

FACULTAD DE MEDICINA. U. DE CHILE

Santiago, Chile

1
Maria Paz Marzolo

Profesor Titular

Departamento de Biología Celular y Molecular

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE, FAC. CIENCIAS BIOLOGICAS, DEPTO. BIOLOGIA

Santiago, Chile

1
Mario Herrera-Marschitz

Profesor titular

Mol. & Clin. Pharmacology

UNIVERSIDAD DE CHILE, FACULTAD DE MEDICINA, PROGRAMA FARMACOLOGIA MOLECULAR & CLINICA, ICBM

Santiago, Chile

1
Paola Morales

Profesor Asociado

Programa Farmacología Molecular & Clínica, ICBM,

Universidad de Chile

Santiago, Chile

1
Maria Otero

Profesor Asociado

UNIVERSIDAD ANDRES BELLO

Santiago, Chile

1
Francisca Bronfman

Full Professor

Instituto de Ciencias Biomédicas

Universidad Andrés Bello

Santiago, Chile

1
Ilona Concha

UNIVERSIDAD AUSTRAL DE CHILE

Valdivia, Chile

1
Loreto Cuitiño

Investigador Asociado

Oftalmología

Hospital Clínico Universidad de Chile

229788866, Chile

1
MANUEL VARAS

Research Professor

UNIVERSIDAD SAN SEBASTIÁN

Santiago, Chile

1
Alfredo Ramírez

Profesor Asociado

Instituto de Ciencia Animal

UNIVERSIDAD AUSTRAL DE CHILE

Valdivia, Chile