Man

Mario GG Herrera-Marschitz Herrera-Marschitz

Profesor titular

UNIVERSIDAD DE CHILE, FACULTAD DE MEDICINA, PROGRAMA FARMACOLOGIA MOLECULAR & CLINICA, ICBM

Santiago, Chile

Líneas de Investigación


Pharmacology, Neurochemistry, Animal Models of Diseases, Perinatal Asphyxia, Addiction Biology, Treatments.

Educación

  •  Doctor Medical Sciences, KAROLINSKA INSTITUTE. Chile, 1986
  •  Docentship, KAROLINSKA INSTITUTE. Suecia, 1991
  •  Physiology & Psychology, COMENIUS UNIVERSITY. Eslovaquia, 1978

Experiencia Académica

  •   Profesor titular Full Time

    UNIVERSIDAD DE CHILE

    Facultad de Medicina

    Santiago, Chile

    2001 - A la fecha

  •   Professor Full Time

    KAROLINSKA INSTITUTE

    Medicine

    Stockholm, Suecia

    1999 - 2003

  •   Docent Full Time

    Medicine

    Stockholm, Chile

    1991 - 1999


 

Article (51)

Activated mesenchymal stem cell administration inhibits chronic alcohol drinking and surpesses relapse-like drinking in high drinker rats
Activation of mitochondrial aldehyde dehydrogenase (ALDH2) by ALDA-1 reduces both the acquisition and maintenance of ethanol intake in rats=> A dual mechanism?
Gold nanorods/si RNA complex administration for knockdown of PARP-1=> a potential treatment for perinatal asphyxia
Intranasal delivery of mesenchemycal stem cell-derived exosomes reduces oxidative stress and markedly inhibits ethanol consumption and post-deprivation relapse drinking.
Intravenous administration of anti-inflammatory mesenchymal stem cell spheroids reduces chronic alcohol intake and abolishes binge-drinking
Regionally impaired redox homeostasis in the brain of rats subjected to global perinatal asphyxia
Acquisition, maintenance and relapse-like alcohol drinking=> lessons from the UChB rat line
Racemic salsolinol and it enantiomers act as agonists of the mu-opioid receptor by activating the Gi protein-adenylate cyclase pathway
Vulnerability to a metabolic challenge following perinatal asphyxia evaluated by organotypic cultures=> effect of neonatal nicotinamide treatment
Vulnerability to a metabolic challenge following perinatal asphyxia evaluated by organotypic culturesL neonatal nicotinamide treatment
Beyond the "First Hit": Marked Inhibition by N-Acetyl Cysteine of Chronic Ethanol Intake But Not of Early Ethanol Intake. Parallel Effects on Ethanol-Induced Saccharin Motivation.
Long-term inhibition of ethanol intake by the administration of an aldehyde dehydrogenase-2 (ALDH2)-coding lentiviral vector into the ventral tegmental area of rats
Perinatal Asphyxia Leads to PARP-1 Overactivity, p65 Translocation, IL-1 beta and TNF-alpha Overexpression, and Apoptotic-Like Cell Death in Mesencephalon of Neonatal Rats: Prevention by Systemic Neonatal Nicotinamide Administration
Gene expression in superior temporal cortex of schizophrenia patients
Overexpression of Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels into the Ventral Tegmental Area Increases the Rewarding Effects of Ethanol in UChB Drinking Rats
Salsolinol, free of isosalsolinol, exerts ethanol-like motivational/sensitization effects leading to increases in ethanol intake
Additive effect of rimonabant and citalopram on extracellular serotonin levels monitored with in vivo microdialysis in rat brain
The Alcohol Deprivation Effect: Marked Inhibition by Anticatalase Gene Administration into the Ventral Tegmental Area in Rats
Further Studies on the Hypothesis of PARP-1 Inhibition as a Strategy for Lessening the Long-Term Effects Produced by Perinatal Asphyxia: Effects of Nicotinamide and Theophylline on PARP-1 Activity in Brain and Peripheral Tissue
Reward and Relapse: Complete Gene-Induced Dissociation in an Animal Model of Alcohol Dependence
Structural synaptic elements are differentially regulated in superior temporal cortex of schizophrenia patients
Ethanol as a Prodrug: Brain Metabolism of Ethanol Mediates its Reinforcing Effects
Perinatal asphyxia: current status and approaches towards neuroprotective strategies, with focus on sentinel proteins
Regulation of immune-modulatory genes in left superior temporal cortex of schizophrenia patients: a genome-wide microarray study
The hypoxic rat model for obstetric complications in schizophrenia
Differential expression of presynaptic genes in a rat model of postnatal hypoxia: relevance to schizophrenia
Nicotinamide prevents the long-term effects of perinatal asphyxia on apoptosis, non-spatial working memory and anxiety in rats
The rotational model and microdialysis: Significance for dopamine signalling, clinical studies, and beyond
Rat strain influences the use of egocentric learning strategies mediated by neostriatum
Acute perinatal asphyxia impairs non-spatial memory and alters motor coordination in adult male rats
Ethanol induces stronger dopamine release in nucleus accumbens (shell) of alcohol-preferring (bibulous) than in alcohol-avoiding (abstainer) rats
Dopamine release in the nucleus accumbens (shell) of two lines of rats selectively bred to prefer or avoid ethanol
Exploring neurocircuitries of the basal ganglia by intracerebral administration of selective neurotoxins
Nicotinamide prevents the effect of perinatal asphyxia on dopamine release evaluated with in vivo microdialysis 3 months after birth
Perinatal asphyxia induces neurogenesis in hippocampus: an organotypic culture study
Plasticity of basal ganglia neurocircuitries following perinatal asphyxia: effect of nicotinamide
Neurochemical and behavioural characterisation of alkoxyamphetamine derivatives in rats
Plasticity of the central nervous system (CNS) following perinatal asphyxia: Does nicotinamide provide neuroprotection?
Spatial cognition and memory: A reversible lesion lidocaine into the anteromedial/posterior parietal cortex (AM/PPC) affects differently working and long-term memory on two foraging tasks
Spatial cognition and memory: a reversible lesion with lidocaine into the anteromedial/posterior parietal cortex (AM/PPC) affects differently working and long-term memory on two foraging tasks
Effect of perinatal asphyxia on tyrosine hydroxylase and D2 and D1 dopamine receptor mRNA levels expressed during early postnatal development in rat brain
Effects of perinatal asphyxia on cell proliferation and neuronal phenotype evaluated with organotypic hippocampal cultures
Effects of perinatal asphyxia on cell survival, neuronal phenotype and neurite growth evaluated with organotypic triple cultures
Modulation of ventral pallidal dopamine and glutamate release by the intravenous anesthetic propofol studied by in vivo microdialysis
Effects of the DT-diaphorase inhibitor dicumarol on striatal monoamine levels in L-DOPA and L-deprenyl pre-treated rats
Nicotinamide prevents the long-term effects of perinatal asphyxia on basal ganglia monoamine systems in the rat
Perinatal asphyxia impairs connectivity and dopamine neurite branching in organotypic triple culture from rat substantia nigra, neostriatum and neocortex
Corticosterone differentially regulates bax, bcl-2 and bcl-x mRNA levels in the rat hippocampus
Effect of single and repeated methamphetamine treatment on neurotransmitter release in substantia nigra and neostriatum of the rat
Inhibition of DT-diaphorase is a requirement for Mn3+ to produce a 6-OH-dopamine like rotational behaviour
Comparison between hypothermia and glutamate antagonism treatments on the immediate outcome of perinatal asphyxia

Abstract (13)

AN ANTICATALASE LENTIVIRAL VECTOR REDUCED ETHANOL INTAKE IN DEVELOPMENTALLY-LEAD-EXPOSED RATS
SALSOLINOL, AN ALCOHOL-DERIVED METABOLITE, ACTS AS AN AGONIST OF THE MU-OPIOID RECEPTOR
A CLEAR PARADOX: AVERSIVE EFFECTS OF LIVER-GENERATED ACETALDEHYDE BUT REWARDING/REINFORCING EFFECTS OF ACETALDEHYDE GENERATED IN THE BRAIN
KNOCKDOWN OF HCN CHANNELS INTO THE VENTRAL TEGMENTAL AREA REDUCES ETHANOL CONSUMPTION IN UCHB DRINKING RATS
SALSOLINOL, FREE OF ISOSALSOLINOL, EXERTS ETHANOL- LIKE MOTIVATIONAL/SENSITIZATION EFFECTS LEADING TO INCREASES IN ETHANOL INTAKE
OVEREXPRESSION OF HCN CHANNELS INTO THE VENTRAL TEGMENTAL AREA INCREASES THE REWARDING EFFECTS OF ETHANOL
COMBINED INHIBITION OF REWARD AND CONDITIONING PREVENTS RELAPSE IN AN ANIMAL MODEL OF ALCOHOL DEPENDENCE
DIFFERENTIAL EXPRESSION OF STRUCTURAL SYNAPTIC ELEMENTS IN THE LEFT SUPERIOR TEMPORAL CORTEX OF SCHIZOPHRENIA PATIENTS
MICROINJECTION OF AN ANTI-CATALASE SHRNA-CODING LENTIVIRAL VECTOR INTO BRAIN VENTRAL TEGMENTAL AREA (VTA) VIRTUALLY ABOLISHES ETHANOL INTAKE BY RATS BRED AS HIGH ALCOHOL DRINKERS
ROLE OF ACETALDEHYDE ON THE MOTIVATIONAL PROPERTIES OF ETHANOL IN RATS BRED AS HEAVY DRINKERS
Acute and long-term neuronal loss induced by perinatal asphyxia: activation of pro-apoptotic, anti-apoptotic and sentinel proteins
Predictive diagnostics of long-term outcomes in perinatal asphyxia
Effect of poly(ADP-ribose) polymerase-1 (PARP-1) inhibition on metabolic insults occurring at birth: promises and limitations

EditorialMaterial (5)

On postnatal CNS plasticity
General introduction: Neurobiology at the 8(th) International Congress on Amino Acids and Proteins, Rome, Italy, September 2003
Introduction: Vulnerability of the CNS to metabolic and drug-related insults (Chapter 1)
Transport proteins: targets for glutamate pharmacology?
Amino acids in neurobiology: Neuroprotective and neurotoxic aspects of amino acids involved in neurotransmission and neuromodulation - General Introduction

Proyecto (12)

Mesenchymal stem cells-secretome provides protection in neonatal hypoxia-deoxygenation. Mechanisms and translational studies
The oxidative stress-neuroinflammation synergy=> role in the perpetuation of alcohol intake and therapeutic avenues.
REWARDING MOLECULES GENERATED FROM ETHANOL IN THE BRAIN
ASPHYXIA AT BIRTH PRIMES CNS DEVELOPMENT AND INCREASES THE VULNERABILITY TO SUBSEQUENT POSTNATAL INSULTS
MODULATION OF NEUROGENESIS BY PERINATAL ASPHYXIA=> ROLE OF DOPAMINE AND REGULATORS OF G-PROTEINS (RGS)
GENE SILENCING OF HCN CHANNELS AND ITS EFFECTS ON THE STIMULATING AND REWARDING EFFECTS OF ETHANOL
Millennium Institute in Bioneuroscience.
ETHANOL AS A PRODRUG
LONG-TERM CHANGES IN BRAIN NEUROCIRCUITRIES PRODUCED BY PERINATAL ASPHYXIA=> IS POLY(ADP-RIBOSE) POLYMERASE-1 (PARP-1) INHIBITION A STRATEGY FOR NEUROPROTECTION?
PLASTICITY OF THE CENTRAL NERVOUS SYSTEM=> EFFECTS OF PERINATAL ASPHYXIA AND METABOLIC INSULTS
Neurocircuitry of the basal ganglia studied with in vivo and in vitro models=> effects of intracerebral and perinatal asphyctic lesions
NEUROCIRCUITRY OF THE BASAL GANGLIA STUDIED WITH IN VIVO AND IN VITRO MODELS=> EFFECTS OF METABOLIC AND INTRACEREBRAL LESIONS

Review (4)

The "First Hit" Toward Alcohol Reinforcement: Role of Ethanol Metabolites
Perinatal asphyxia: CNS development and deficits with delayed onset
Gene specific modifications unravel ethanol and acetaldehyde actions
Plasticity of hippocampus following perinatal asphyxia: Effects on postnatal apoptosis and neurogenesis
62
Mario Herrera-Marschitz

Profesor titular

Mol. & Clin. Pharmacology

UNIVERSIDAD DE CHILE, FACULTAD DE MEDICINA, PROGRAMA FARMACOLOGIA MOLECULAR & CLINICA, ICBM

Santiago, Chile

32
Paola Morales

Profesor Asociado

Programa Farmacología Molecular & Clínica, ICBM,

Universidad de Chile

Santiago, Chile

12
Yedy Israel

Profesor Titular

Farmacologia Molecular y Clinica

UNIVERSIDAD DE CHILE, FACULTAD DE CS QUIMICAS Y FARMACÉUTICAS, LAB. FARMACOTERAPIA GÉNICA

Santiago, Chile

7
Eduardo Karahanian

Professor

INSTITUTO DE CIENCIAS BIOMEDICAS

UNIVERSIDAD AUTONOMA DE CHILE

Santiago, Chile

7
Eduardo Karahanian

Académico Investigador

Facultad de Ciencias de la Salud

Universidad Autónoma de Chile

Santiago, Chile

7
Maria Quintanilla

PROFESOR ASOCIADO

FARMACOLOGÍA MOLECULAR Y CLÍNICA

UNIVERSIDAD DE CHILE, FACULLTAD DE MEDICINA, INSTITUTO DE CIENCIAS BIOMÉDICAS, PROGRAMA DE FARMACOLOGÍA MOLECULAR Y CLÍNICA

Santiago, Chile

4
JENNY FIEDLER

LAB. NEUROPLASTICIDAD Y NEUROGENETICA. DEPTO BIOQUIMICA Y BIOLOGÍA MOLECULAR. FAC. CIENCIAS QUÍMICAS Y FARMACÉUTICAS. UNIVERSIDAD DE CHILE

Santiago, Chile

3
Edgardo Rojas

Académico e Investigador

Ciencias Químicas y Biológicas

Universidad Bernardo OHiggins

Santiago, Chile

3
Marianne Buscaglia

Estudiante de Doctorado en Ciencias Biológicas, mención Genética Molecular y Microbiología

Genética Molecular y Microbiología

Pontificia Universidad Católica de Chile

Santiago, Chile

2
Lisette Leyton

Full Professor

Cell and Molecular Biology

FACULTAD DE MEDICINA UNIVERSIDAD DE CHILE

Santiago, Chile

2
Sergio Cárdenas

Coordinador de Investigación e investigador

Centro de Ingeniería y desarrollo sostenible

Universidad Central de Chile

Santiago, Chile

1
jose valdes

Profesor Asociado

Neurociencia

UNIVERSIDAD DE CHILE

Santiago, Chile

1
Eduardo Parra

ACADÉMICO - ESCUELA DE MEDICINA

MEDICINA

UNIVERSIDAD DE TARAPACA

Arica, Chile

1
Gerald Zapata

DEPARTAMENTO DE QUÍMICA INORGÁNICA Y ANALÍTICA FACULTAD DE CIENCIAS QUÍMICAS Y FARMACÉUTICAS UNIVERSIDAD DE CHILE

Santiago, Chile

1
Ricardo Delgado

Profesor Adjunto

Biología

UNIVERSIDAD DE CHILE, FACULTAD DE CIENCIAS, DEPARTAMENTO DE BIOLOGIA

Santiago, Chile

1
Andrés Couve

Profesor Titular

Neurociencia

FACULTAD DE MEDICINA, UNIVERSIDAD DE CHILE

Santiago, Chile

1
Bruce Cassels

Profesor Titular

Departamento de Química

UNIVERSIDAD DE CHILE, FACULTAD DE CIENCIAS, DEPARTAMENTO DE QUÍMICA

Santiago, Chile

1
Marcela Hermoso

Full Professor

School of Medicine

UNIVERSIDAD DE CHILE

Santiago, Chile

1
Felipe Salech

Academic

Medicine

Universidad de Chile / Facultad de Medicina

Santiago, Chile

1
JAVIER BRAVO

PROFESOR ADJUNTO

INSTITUTO DE QUÍMICA

PONTIFICIA UNIVERSIDAD CATÓLICA DE VALPARAISO

VALPARAÍSO, Chile

1
Pablo Berríos

Asistente de investigación

Universidad del Desarrollo

Santiago, Chile