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JAVIER ANDRÉS BRAVO VIVALLO

PROFESOR ADJUNTO

PONTIFICIA UNIVERSIDAD CATÓLICA DE VALPARAISO

VALPARAÍSO, Chile

BIOCHEMISTRY; NEUROSCIENCE; NEUROGASTROPHARMACOLOGY; Biochemistry and pharmacology of gastrointestinal system; Endocrinology of brain-gut axis

Biochemistry, UNIVERSIDAD DE CHILE. Chile, 2007
Biochemist, UNIVERSIDAD DE CHILE. Chile, 2002
Biochemistry, UNIVERSIDAD DE CHILE. Chile, 2001

Profesor Adjunto Full Time

PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

Facultad de Ciencias

VALPARAÍSO, Chile

2012 - A la fecha
POST-DOCTORAL FELOW Full Time

UNIVERSITY COLLEGE CORK

ALIMENTARY PHARMABIOTIC CENTRE (APC)

CORK, Irlanda

2007 - 2011
LECTURER Part Time

UNIVERSIDAD DE CHILE

FACULTAD DE CIENCIAS QUÍMICAS Y FARMACÉUTICAS

SANTIAGO, Chile

2006 - 2006

PROFESOR ADJUNTO Full Time

PONTIFICIA UNIVERSIDAD CATÓLICA DE VALPARAÍSO

VALPARAÍSO, Chile

2012 - A la fecha
POST-DOCTORAL FELLOW Full Time

UNIVERSITY COLLEGE CORK

CORK, Irlanda

2007 - 2011
LECTURER Part Time

UNIVERSIDAD DE CHILE

SANTIAGO, Chile

2006 - 2006


Increased amygdalar metabotropic glutamate receptor 7 mRNA in a genetic mouse model of impaired fear extinction. O'Connor, Richard M; McCafferty, Cian P; Bravo, Javier A; Singewald, Nicolas; Holmes, Andrew; Cryan, John F Article Psychopharmacology (2019)
Do Obese Bacteria Make us “Want them”? Intestinal Microbiota, Mesocorticolimbic Circuit and Non-Homeostatic Feeding Urrutia-Piñones, J; Illanes-González, J; López-Aguilera, A; Julio-Pieper, M; Bravo, JA Article Current Behavioral Neuroscience Reports (2018)
ANXIOGENIC EFFECTS OF A LACTOBACILLUS, INULIN AND THE SYNBIOTIC ON HEALTHY JUVENILE RATS Barrera-Bugueño, Camila; Realini, Ornella; Escobar-Luna, Jorge; Sotomayor-Zárate, Ramón; Gotteland, Martin; Julio-Pieper, Marcela; Bravo, Javier A. Article ISI SCOPUS NEUROSCIENCE (2017)
Protein Malnutrition During Juvenile Age Increases Ileal and Colonic Permeability in Rats Eyzaguirre-Velásquez, Johana; Olavarría-Ramírez, Loreto; González-Arancibia, Camila; Díaz-Merino, Camila; Ariz, Raúl; López, Silvana; Quiroz, Waldo; Beltrán, Caroll J.; Bravo, Javier A.; Julio-Pieper, Marcela Article ISI SCOPUS JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION (2017)
Intestinal Barrier and Behavior. Julio-Pieper, M; Bravo, J A Article International review of neurobiology (2016)
What goes around comes around=> novel pharmacological targets in the gut-brain axis. González-Arancibia, Camila; Escobar-Luna, Jorge; Barrera-Bugueño, Camila; Díaz-Zepeda, Camilo; González-Toro, María P; Olavarría-Ramírez, Loreto; Zanelli-Massai, Francesca; Gotteland, Martin; Bravo, Javier A; Julio-Pieper, Marcela Article Therapeutic advances in gastroenterology (2016)
Association of N-cadherin levels and downstream effectors of Rho GTPases with dendritic spine loss induced by chronic stress in rat hippocampal neurons Castañeda P; Munoz M.; Garcia-Rojo, G; Ulloa, JL.; Bravo, JA; Marquez R.; Garcia-Perez, MA; Arancibia D.; Araneda, K; Rojas, PS; Mondaca-Ruff, D; Diaz-Veliz, G; Mora S.; Aliaga, E; Fiedler, JL Article ISI SCOPUS Journal of Neuroscience Research (2015)
Blancos Farmacológicos en el eje intestino-cerebro Díaz-Cepeda, C; Escobar-Luna, J; González-Arancibia, C; González-Toro, MP; Olavarría-Ramirez, L; Zanelli-Massai, F; Bravo, JA; Julio-Pieper, M Article <Revista de Farmacologia de Chile (2015)
Short-term effects of Poly(I:C) on gut permeability Moyano-Porcile, V; Olavarria-Ramirez, L; Gonzalez-Arancibia, C; Bravo, JA; Julio-Pieper, M Article ISI SCOPUS Pharmacological Research (2015)
Early-life stress induces persistent alterations in 5-HT1A receptor and serotonin transporter mRNA expression in the adult rat brain Bravo, JA; Dinan, TG; Cryan, JF Article ISI SCOPUS FRONTIERS IN MOLECULAR NEUROSCIENCE (2014)
GABAB(1) receptor subunit isoforms differentially regulate stress resilience O'Leary O.F.; Felice D.; Galimberti S.; Savignac H.M.; Bravo J.A.; Crowley T.; El Yacoubi M.; Vaugeois J.-M.; Gassmann M.; Bettler B.; Dinan T.G.; Cryan J.F. Article SCOPUS Proceedings of the National Academy of Sciences of the United States of America (2014)
Review article: intestinal barrier dysfunction and central nervous system disorders - a controversial association Julio-Pieper, M; Bravo, J.A.; Aliaga, E; Gotteland, M Article Aliment Pharmacol Ther (2014)
Differential visceral nociceptive, behavioural and neurochemical responses to an immune challenge in the stress-sensitive Wistar Kyoto rat strain O’Mahony SM, Clarke G, McKernan D, Bravo JA, Dinan TG, Cryan JF Article Behav Brain Res (2013)
Chronic stress-induced alterations in mouse colonic 5-HT and defecation responses are strain dependent Julio-Pieper, M; O'Mahony, CM; Clarke, G; Bravo, JA; Dinan, TG; Cryan, JF Article ISI STRESS-THE INTERNATIONAL JOURNAL ON THE BIOLOGY OF STRESS (2012)
Communication between gastrointestinal bacteria and the nervous system Bravo J.A.; Julio-Pieper, M; Forsythe P.; Kunze W.; Dinan T.G.; Bienenstock J.; Cryan J.F. Article ISI SCOPUS Current Opinion in Pharmacology (2012)
Genetic strain differences in fear inhibition associate with variation in neuroendocrine, autonomic and amygdala dendritic phenotypes Camp M, Martin K, Lederle L, Graybeal C, Gaburro S, Debrouse, L, Ihne J, Bravo JA, O’Connor R, Ciocchi S, Wellman C, Lüthi A, Cryan JF, Singewald N, Holmes A Article Neuropsychopharmacology (2012)
Hippocampal group III mGlu receptor mRNA levels are not altered in specific mouse models of stress, depression and antidepressant action O'Connor RM, Pusceddu M, O'Leary OF, Savignac HM, Bravo JA, El Yacoubi M, Vaugeois JM, Dinan TG, Cryan JF Article Pharmacol Biochem Behav (2012)
Chronic stress-induced alterations in mouse colonic 5-HT and defecation responses are strain dependent Julio-Pieper M, O’Mahony CM, Clarke G, Bravo JA, Dinan TG, Cryan JF Article Stress (2011)
MicroRNAs: a novel therapeutic target for schizophrenia. Bravo JA, Dinan TG Article Current Pharma Design (2011)
The Gut-Brain Axis: Ingestion of a Lactobacillus Strain Regulates Emotional Behaviour and Central GABA Receptor Expression in the Mouse via the Vagus Nerve. Bravo JA, Forsythe P, Chew M, Escaravage E, Savignac HM, Dinan TG, Bienenstock J, Cryan JF. Article PNAS (2011)
A novel role for mGluR7: modulation of faecal water content and colonic electrolyte transport in the Mouse Julio-Pieper M, Hyland NH, Bravo JA, Dinan TG, Cryan JF Article Brit J Pharmacol (2010)
A novel role for the metabotropic glutamate receptor-7: modulation of faecal water content and colonic electrolyte transport in the mouse Julio-Pieper, M; Hyland, NP; Bravo, JA; Dinan, TG; Cryan, JF Article ISI BRITISH JOURNAL OF PHARMACOLOGY (2010)
Alterations in the Central CRF System of Two Different Rat Models of Comorbid Depression and Functional Gastrointestinal Disorders Bravo JA, Dinan TG, Cryan JF Article Intl J Neuropshycopharma (2010)
Comparison of hippocampal metabotropic glutamate receptor 7 (mGlu7) mRNA levels in two animal models of depression O’Mahony CM, Bravo JA, Dinan TG, Cryan JF Article Neurosci Lett (2010)
Comparison of the antidepressant sertraline on differential depression-like behaviors elicited by restraint stress and repeated corticosterone administration Ulloa, JL.; Castañeda P; Berríos C.; Diaz-Veliz, G; Mora S.; Bravo, JA; Araneda, K; Menares C.; Morales P.; Fiedler, JL Article ISI SCOPUS Pharmacology Biochemistry and Behavior (2010)
Desipramine prevents stress-induced changes in depressive-like behavior and hippocampal markers of neuroprotection Bravo, JA; Diaz-Veliz, G; Mora S.; Ulloa, JL.; Berthoud VM.; Morales P.; Arancibia S.; Fiedler, JL Article ISI SCOPUS BEHAVIOURAL PHARMACOLOGY (2009)
Adrenalectomy promotes a permanent decrease of plasma corticoid levels and a transient increase of apoptosis and the expression of Transforming Growth Factor Î²1 (TGF-Î²1) in hippocampus: Effect of a TGF-Î²1 oligo-antisense Bravo J.A.; Parra C.S.; Andres S.; Lara H.E.; Fiedler J.L.; Arancibia S.; Morales P.; Herrera-Marschitz M.; Herrera L. Article SCOPUS BMC NEUROSCIENCE (2006)
Effects of long-term adrenalectomy on apoptosis and neuroprotection in the rat hippocampus Andres S; Cardenas, S; Parra C.; Bravo, J.; Greiner M.; Rojas P.; Morales P.; Lara, H; Fiedler J. Article ISI SCOPUS ENDOCRINE (2006)
Effects of nerve growth factor (NGF) on blood vessels area and expression of the angiogenic factors VEGF and TGFbetaI in the rat ovary Julio-Pieper, M; Lara, HE; Bravo, JA; Romero C. Article ISI SCOPUS REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY (2006)
Corticosterone differentially regulates bax, bcl-2 and bcl-x mRNA levels in the rat hippocampus Cardenas sp; Parra C.; Bravo, J.; Morales P.; Lara, HE; Herrera-Marschitz, M; Fiedler, JL Article ISI SCOPUS NEUROSCIENCE LETTERS (2002)
Adrenalectomy regulates apoptotic-associated genes in rat hippocampus Greiner M.; Cardenas, S; Parra C.; Bravo, J.; Avalos, AM; Paredes A.; Lara, HE; Fiedler, JL Article ISI SCOPUS ENDOCRINE (2001)


The Future of Prebiotics and Probiotics Brunser, O; Bravo, JA; Gotteland, M; Otles, S BookSection (2014)
What are the possible consequences of chronic stress in central nevous system? Fiedler, JL; Bravo, J; Ulloa, JL; Aboitiz F.; Dagnino-Subiabre, A BookSection (2007)


Microbiota Intestinal y Estrés Bravo, JA ConferencePaper (2013)
Microbiota intestinal y sistema nervioso Bravo, JA ConferencePaper (2013)
Microbiota y su impacto en la salud mental Bravo, JA ConferencePaper (2013)
Probióticos y Sistema Nervioso Central Bravo, JA ConferencePaper (2013)
The Influence of Intestinal Microbiota on Human Behaviour Bravo, JA ConferencePaper (2013)


Anxiogenic effects of probiotics, prebiotics and synbiotic son healthy juvenile rats Bravo, JA; Barrera-Bugueño, C; Escobar-Luna, J; Realini, O; Sotomayor- Zárate, R; Gotteland, M; Julio-Pieper, M ConferencePoster (2016)
Differential effects of SSRIs on rat intestinal permeability and immune response markers Julio-Pieper, M; Eyzaguirre-Velásquez, J; González-Arancibia, C; Olavarría-Ramirez, L; Escobar-Luna, J; Barrera-Bugueño, C; Bravo, JA ConferencePoster (2016)
Early-life dysbiosis and its effects on anxiety-like behaviors in the infant rat Bravo, JA; Ponce-Guequen, E; Barrera-Bugueño, C; Escobar-Luna, J; Gotteland, M; Julio-Pieper, M ConferencePoster (2015)
Early-life dysbiosis in infant sprague-dawley rats: effect on anxiety-like behaviors and plasma corticosterone levels Ponce-Guequen, E; Barrera-Bugueño, C; Eyzaguirre-Velásquez, J; Escobar-Luna, J; Olavarría-Ramirez, L; Gotteland, M; Julio-Pieper, M; Bravo, JA ConferencePoster (2015)
Early-life intestinal dysbiosis and its impact on stress-related behaviours in young rats (SIMPOSIO) Bravo, JA ConferencePoster (2015)
Ex-vivo effects of fluoxetine on the rat intestinal barrier: Relevance to disorders of the brain-gut axis Julio-Pieper, M; González-Arancibia, C; González-Toro, MP; Bravo, JA ConferencePoster (2015)
Increased intestinal permeability induced by diet modification: a novel animal model for pharmacological studies of the gut barrier Eyzaguirre-Velásquez, J; Olavarría-Ramírez, L; González-Arancibia, C; Escobar-Luna, J; Díaz-Merino, C; Barrera-Bugueño, C; Bravo, JA; Julio-Pieper, M ConferencePoster (2015)
Rats exposed prenatally to valproate display decreased colonic permeability to macromolecules Olavarría-Ramirez, L; Moyano-Porcile, V; González-Arancibia, C; Díaz-Cepeda, C; Valencia, M; Aliaga, E; Bravo, JA; Julio-Pieper, M ConferencePoster (2015)


Effects of early-life intestinal dysbiosis on the rat’s mesocorticolimbic circuit FONDECYT (1190729) Proyecto 2019-2022 Inv. Principal
OBESITY AND ALTERATIONS OF COLON SUBMUCOSAL NEURONS FONDECYT (1181019) Proyecto 2018-2021 Coinvestigador(a)
THE EFFECT OF ANTIBIOTICS IN EARLY-LIFE ON BRAIN FUNCTION AND BEHAVIOUR CANADIAN INSTITUTES OF HEALTH RESEARCH / IDRC (108189) Proyecto 2016-2019 Coinvestigador(a)
Aumento de la permeabilidad intestinal y activación de neuronas entéricas en ratas con malnutrición VICERRECTORÍA DE INVESTIGACIÓN Y ESTUDIOSAVANZADOS (VRIEA), PONTIFICIA UNIVERSIDAD CATÓLICA DEVALPARAÍSO Proyecto 2015-2015 Coinvestigador(a)
EARLY-LIFE ALTERATIONS OF GUT MICROBIOTA AND ITS IMPACT ON INFANT RAT INTESTINAL BARRIER FUNCTION AND STRESS-RELATED BEHAVIOUR FONDECYT (1140776) Proyecto 2014-2017 Inv. Principal
LA ACTIVACIÓN DEL RECEPTOR TLR-2 MODULA LA PRODUCCIÓN DE UROCORTINA II EN CÉLULAS EPITELIALES HUMANAS DE COLON VICERRECTORÍA DE INVESTIGACIÓN Y ESTUDIOS AVANZADOS, PONTIFICIA UNIVERSIDAD CATÓLICA DE VALPARAÍSO, CHILE (37.386/2014) Proyecto 2014-2014 Inv. Responsable
ALTERACIONES EN LA FUNCIÓN BARRERA INTESTINAL EN UN MODELO ANIMAL DE AUTISMO VICERRECTORÍA DE INVESTIGACIÓN Y ESTUDIOSAVANZADOS (VRIEA), PONTIFICIA UNIVERSIDAD CATÓLICA DEVALPARAÍSO (037.302/2013) Proyecto 2013-2013 Coinvestigador(a)
EFECTO DEL ESTRÉS POR SEPARACIÓN MATERNA EN LA EXPRESIÓN DE ARNM DEL RECEPTOR 5-HT1A Y TRANSPORTADOR DE SEROTONINA EN EL CEREBRO DE RATA VICERRECTORÍA DE INVESTIGACIÓN Y ESTUDIOSAVANZADOS (VRIEA), PONTIFICIA UNIVERSIDAD CATÓLICA DEVALPARAÍSO (037.499/2013) Proyecto 2013-2013 Inv. Responsable
USE OF ANTIDEPRESSANTS TO PROTECT INTESTINAL BARRIER FUNCTION FONDECYT (1130213) Proyecto 2013-2015 Coinvestigador(a)
ALTERACIONES EN LA FUNCIÓN BARRERA INTESTINAL EN UN MODELO ANIMAL DE AUTISMO Julio-Pieper, M; Bravo, JA; Aliaga, E Proyecto (0)
Aumento de la permeabilidad intestinal y activación de neuronas entéricas en ratas con malnutrición Julio-Pieper, M; Bravo, JA; Quiroz, W; Beltran, C Proyecto (0)
EARLY-LIFE ALTERATIONS OF GUT MICROBIOTA AND ITS IMPACT ON INFANT RAT INTESTINAL BARRIER FUNCTION AND STRESS-RELATED BEHAVIOUR Bravo, JA; Julio-Pieper, M Proyecto (0)
EFECTO DE LA MODULACIÓN COLINÉRGICA SOBRE MARCADORES DE INFLAMACIÓN: RELEVANCIA PARA EL SÍNDROME DE INTESTINO IRRITABLE Bravo, JA Proyecto (0)
EFECTO DEL ESTRÉS POR SEPARACIÓN MATERNA EN LA EXPRESIÓN DE ARNM DEL RECEPTOR 5-HT1A Y TRANSPORTADOR DE SEROTONINA EN EL CEREBRO DE RATA Bravo, JA Proyecto (0)
Efectos de prebióticos y probióticos en el sistema nervioso central de la rata juvenil Bravo, JA; Julio-Pieper, M; Sotomayor-Zarate, R Proyecto (0)
USE OF ANTIDEPRESSANTS TO PROTECT INTESTINAL BARRIER FUNCTION Julio-Pieper, M; Bravo, JA Proyecto (0)


Do your gut microbes affect your brain dopamine? GonzÃ¡lez-Arancibia C.; Urrutia-PiÃ±ones J.; Illanes-GonzÃ¡lez J.; Martinez-Pinto J.; Sotomayor-ZÃ¡rate R.; Julio-Pieper M.; Bravo J.A. Review ISI SCOPUS PSYCHOPHARMACOLOGY (2019)
Investigating Gut Permeability in Animal Models of Disease Gonzalez-Gonzalez, M; Diaz-Zepeda, C; Eyzaguirre-Velasquez, J; Gonzalez-Arancibia, C; Bravo, JA; Julio-Pieper, M Review ISI SCOPUS FRONTIERS IN PHYSIOLOGY (2019)
What goes around comes around: Novel pharmacological targets in the gut-brain axis González-Arancibia C.; Escobar-Luna J.; Barrera-Bugueño C.; Díaz-Zepeda C.; González-Toro M.P.; Olavarría-Ramírez L.; Zanelli-Massai F.; Gotteland M.; Bravo J.A.; Julio-Pieper, M Review SCOPUS Therapeutic Advances in Gastroenterology (2015)
Review article: intestinal barrier dysfunction and central nervous system disorders - a controversial association Julio-Pieper, M; Bravo, JA; Aliaga, E; Gotteland M. Review ISI SCOPUS ALIMENTARY PHARMACOLOGY & THERAPEUTICS (2014)