Man

Paola Morales Retamales

Profesor Asociado

Universidad de Chile

Santiago, Chile

Líneas de Investigación


Neuropharmacology; Neurochemistry; Neuroplasticity; PathoPhysiology of Perinatal Asphyxia; Neuropharmacology of basal ganglia; Neurognesis postnatal; Plasticidad morfofuncional del sistema nervioso frente a injurias cerebrales; Muerte celular/Neuroprotección

Educación

  •  Biomedical Sciences-Neuroscience, UNIVERSIDAD DE CHILE. Chile, 2005
  •  Neurobiology and Behavioral sciences, UNIVERSIDAD DE CHILE. Chile, 1995
  •  Biology, UNIVERSIDAD DE CHILE. Chile, 1989

Experiencia Académica

  •   Instructor Part Time

    UNIVERSIDAD DE CHILE

    Medicina

    Santiago, Chile

    1996 - 1998

  •   Instructor Full Time

    Medicina

    Santiago, Chile

    1998 - 2000

  •   Instructor Full Time

    UNIVERSIDAD DE CHILE

    Medicina

    Santiago, Chile

    2000 - 2005

  •   Profesor Asistente Full Time

    UNIVERSIDAD DE CHILE

    Medicina

    Santiago, Chile

    2005 - 2009

  •   Profesor Asociado Full Time

    UNIVERSIDAD DE CHILE

    Medicina

    Santiago, Chile

    2009 - A la fecha

Experiencia Profesional

  •   Instructor Full Time

    Universidad de Chile

    Santiago, Chile

    1998 - 2005

  •   Profesor Asistente Full Time

    Universidad de Chile

    Santiago, Chile

    2005 - 2009

  •   Profesor Asociado Full Time

    Universidad de Chile

    Santiago, Chile

    2009 - A la fecha

  •   Instructor Part Time

    Universidad de Chile

    Santiago, Chile

    1996 - 1998

Formación de Capital Humano


Postdoctoral Student
Nancy Farfán Troncoso Mesenchymal stem cells-secretome to the rescue of mitochondrial integrity in perinatal asphyxia via NRF2. Fondecyt 3210771

Supervision de Tesis de Doctorado

Marta Zamorano Cataldo, PhD in Biochemistry, Faculty of Chemistry and Pharmacy, Universidad de Chile.Effect of Intranasal DFX-preconditioned Mesenchymal Stem Cell Secretome administration on perinatal asphyxia induced mitochondrial dysfunction and cell loss in rat hippocampus: Role of Nrf2 activation. In Progress (Supervisor)

Andrea Tapia Bustos, PhD in Pharmacology, Faculty of Chemistry and Pharmacy, Universidad de Chile. Perinatal asphyxia produces long-term oligodendrocyte damage and demyelination in rat brain: prevention by intranasal administration of stem cells. Co supervisor, Finished July 16 Julio 2020. (Supervisor)

Ronald Perez Lobos , PhD in Biochemistry, Faculty of Chemistry and Pharmacy, Universidad de Chile. The vulnerability of basal ganglia is due to a long-term impairment of mitochondrial dynamics: role of HIF-1alpha and PARP-1 signalling. In progress

Manuel Gutierrez Hernández , PhD in Biomedical Sciences (DCBM). Faculty of Medicine, University of Chile. RGS proteins associated to dopamine receptors: Modulation by unilateral 6-OHDA lesion and dopamine agonists in the basal ganglia of the rat. Finished August 2016 (Co-Supervisor)

Tanya Neira, Doctorate in Biomedical Sciences (DCBM). Faculty of Medicine, University of Chile. PARP-1 and inflammatory responses in mesencephalon of rat: Effects of perinatal asphyxia. Finished January 2015 (Co-Supervisor)

Edgardo Rojas Mancilla, Doctorate in Biomedical Sciences (DCBM). Faculty of Medicine, University of Chile. Severe perinatal asphyxia produces HIF-1? translocation and astrocyte reactivity: Morphological and functional changes in rat hippocampus. Finished July 31,2015(Co-supervisor)

Supervisión of Master thesis

Sofía Constanza Adasme Reyes, Master in Biochemistry, Faculty of Chemistry and Pharmacy, Universidad de Chile, Alda-1 administration decreases oxidative stress and brain neuroinflammation associated with chronic alcohol and nicotine consumption in UChB rats. In Progress 2021 (Co-supervisor)

Raúl Alvarado Rosas, Master in Neuroscience, Faculty of Medicine, University of Chile. The N-acetylcysteine-induced reduction of chronic alcohol
comsumption is associated to the activation of the Nrf2/ARE pathway in high-alcohol-drinking UChB rats. Finished March 22, 2021 (Co-supervisor)

Norton Contreras Paredes. Master in Neuroscience, Faculty of Medicine, University of Chile. Effect of treatment with mesenchymal stem cell-derived secretomes on cognitive deficits induced by a perinatal asphyxia model. In Progress (Co-Supervisor)

Martina Redel Master in Neurosciences, Faculty of Medicine, University of Chile. Effect of the administration of mesenchymal stem cell-derived secretomes on oligodendrocyte development in a perinatal asphyxia model. In Progress (Supervisor)

Jessica Sánchez Torres, Master in Neurosciences, Faculty of Medicine, University of Chile. Effect of the histamine H3 receptor antagonist on spatial memory, neurogenesis and hippocampal plasticity in rats with perinatal asphyxia. Finished March 19, 2018 (Co-Supervisor).

Javier Ignacio Silva García Master in Neuroscience, Faculty of Medicine, University of Chile. Effect of voluntary physical exercise on memory capacities in an animal model of perinatal asphyxia. Completed June 6, 2017 (Co-supervisor)

Marianne Alexandra Buscaglia Fernández Master in Biochemistry, Faculty of Medicine, University of Chile. Effect of acute administration of ethanol in the formation of protein-acetaldehydeadducts in the mesocorticolimbic dopaminergic system. Finished January 31, 2013 (Co-Supervisor).

Daniela Esmar Gutierrez Master in Neuroscience, Faculty of Medicine, University of Chile. Postnatal cell proliferation in the hippocampus is modulated by dopaminergic systems in the rat. Finished, December 6, 2013 Supervisor.

María José Díaz Latas, Master in Biochemistry, Andres Bello University. Quantitative Analysis of Copper in rat hippocampus. Finished May 2012 (Co-Supervisor)

María Mercedes Casas Alarcón, Master in Physiopathology, Medical Faculty, University of Chile. Involvement of ryanodine receptor-2 in memory associated with fear. Finished December 2011 (Co-Supervisor)

Verena Klawitter Melkonian, Master in Neuroscience, Medical Faculty, University of Chile (2004-2006). Effects of perinatal on basal ganglia neurocircuitry. Approved with honour on May 30, 2006 (selected among the 3 best thesis by the Chilean Society of Molecular and Cellular Biology, 2006) (Co-Supervision).

Undergraduate Student Supervisor

María José Ortega, Javiera Rojas Ríos, Effects of intranasal administration of secretomes derived from pre-conditioned stem cells on demyelination induced by perinatal asphyxia. TThesis to qualify for the degree of Medical Technologist. University Andrés Bello. Finished September 2020.

Araya M, Monzon E, Mesenchymal stem cell secretomas as treatment in perinatal asphyxia Thesis to qualify for the degree of Medical Technologist. Andres Bello University. Finished August 2019

Jorge Ruiz Campillay Study of mitochondrial function and neuronal vulnerability to recurrent metabolic insults in brain tissue exposed to perinatal asphyxia. Thesis to qualify for the degree of Medical Technologist, University of Chile Finished 2016 (Supervisor).

Mariana Rubio Effect of deafferentation of dopaminergic afferents on the expression of dopamine receptors, RGSs proteins and their relationship with the neurogenesis of the hippocampus of adult rats. Thesis to qualify for the degree of Medical Technologist, Universidad San Sebastian. Finished 2015 (Supervisor)

Marcos Sert Dependent vulnerability of perinatal asphyxia of dopaminergic neurons to postnatal metabolic insults ”Montanarer Perez Sofia, Effect of nperinatal asphyxia and dopaminergic de-afferentiation on the expression of SNGN in rat brain evaluated with immunohistochemistry, confocal microscopy and stereological quantification. TThesis to qualify for the degree of Medical Technologist. Andres Bello University, Completed December 2015

Paloma Saez Study of SOD2 expression in dopaminergic neurons of rat brains subjected to perinatal asphyxia. TThesis to qualify for the degree of Medical Technologist, Andres Bello University, Finished December 2015 (Supervisor).

Sofia Montanares Perez Effect of nperinatal asphyxia and dopaminergic de-afferentiation on the expression of SCGN in rat brain evaluated with immunohistochemistry, confocal microscopy and stereological quantification. Thesis to qualify for the degree of Medical Technologist, Andres Bello University, Finished December 2015 (Supervisor)

Benjamín Rivera, Characterization of RGSs proteins and dopamine receptors in the sub-ventricular zone (SVZ) in a rat perinatal asphyxia model. Thesis to qualify for the degree of Medical Technologist, University of Chile. Finished 2014 (Supervisor)

Belén Urqueta Herrera, Inflammation and microglial activation: Effects of perinatal asphyxia in neonatal rat hippocampus. Thesis to qualify for the degree of Medical Technologist. University of Chile. Finished 2013 (Supervisor).

Antonella Jara, Regulation of postnatal neurogenesis by the basic fibroblast growth factor, bFGF, in normal and brain injury conditions: role of the Spry, SEF and FLRT3 proteins. Thesis to qualify for the degree of Biochemistry, Catholic University of Valparaíso. Finished Dec 2010 (Supervisor)


Difusión y Transferencia


LUN (Diario Las Ultimas Noticias) Entrevista: Biofármaco previene el daño causado por la falta de oxigeno en recién nacidos. Octubre 21, 2020.

Entrevista radial Radio DUNA: Paola Morales y biofármaco para tratar asfixia en recién nacidos: “Hasta el momento hemos encontrado buenos resultados con una sola administración. Octubre 27, 2020 https://unlimited1-cl-vod.dps.live/vod/cl2/duna/618396/czoRpDX1u3o.mp3?nimblesessionid=39914391
https://www.duna.cl/programa/aire-fresco/2020/10/27/paola-morales-y-biofarmaco-para-tratar-asfixia-en-recien-nacidos-hasta-el-momento-hemos-encontrado-buenos-resultados-con-una-sola-administracion/

Conferencia ICBM-Depto Neurociencias, Facultad de Medicina, Universidad de Chile: Secretomas derivados de células madres mesenquimales: Una alternativa en el tratamiento de alteraciones metabólicas
al momento de nacer. Octubre 29, 2020 https://www.youtube.com/watch?v=TGoZjbpDGVY

Conferencia Programa Fisiopatología Facultad de Medicina campus oriente: “Mesenchymal stem cells as a
novel therapeutic strategy against neonatal asphyxia”. Septiembre 2, 2019.

Nota de prensa La tercera, Qué pasa: Científicos chilenos crean innovador spray nasal basado en células madre para revertir daños cerebrales. Abril, 23, 2019 https://www.latercera.com/que-pasa/noticia/cientificos-chilenos-crean-innovador-spray-nasal-basado-celulas-madre-revertir-danos-cerebrales/625695/

Nota de prensa EMOL, Vinculación con el medio: Investigan spray nasal que permitiría revertir los daños cerebrales de la asfixia al nacer. https://vcm.emol.com/5533/investigacion/danos-cerebrales-de-la-asfixia-al-nacer/ Abril 22, 2019.

Conferencia Mesenchymal stem cells as a novel therapeutic strategy against neonatal asphyxia. Pontificia Universidad Católica, Neonatología, Julio 27, 2019.

Nota de prensa TV Chilevision -CNN Más que un recuerdo de infancia: Dientes de leche podrían ser una solución médica gracias a las células madres https://www.futuro360.com/videos/dientes-leche-celulas-madres_20190410/ 1/10 Abril, 10, 2019

Conicyt 1000 cientificos 1000 aulas Título charla: Nuevas neuronas en el cerebro: implicancia en el aprendizaje y la reparación cerebral Fecha de la charla: 27-09-2019 02:00 Establecimiento: Escuela el Renoval, Concepción.

Nota de prensa Facultad de Medicina, Universidad de Chile Spray nasal basado en secretomas de células madres revierte los daños cerebrales inducidos por la asfixia perinatal Abril 12, 2019. http://www.medicina.uchile.cl/noticias/152768/spray-nasal-de-secretomas-revierte-dano-cerebral-por-asfixia-perinatal#

Nota de prensa Vista previa Noticias de la Facultad e Medicina Spray nasal basado en secretomas de células madres revierte los daños cerebrales inducidos por la asfixia perinatal. Abril 12, 2019.
http://www.uchile.cl/noticias/152974/spray-nasal-de-secretomas-revierte-dano-cerebral-por-asfixia-perinatal

Nota de Prensa Facultad de Medicina: Proyecto Fondecyt Regular 2019 Spray nasal basado en secretomas de células madres revierte los daños cerebrales inducidos por la asfixia perinatal. Abril 12, 2019. http://www.medicina.uchile.cl/noticias/spray-nasal-de-secretomas-revierte-dano-cerebral-por-asfixia-perinatal

Nota de Prensa Universidad de Chile: Avances médicos: Investigadora estudia spray nasal que permitiría revertir los daños cerebrales inducidos por la asfixia perinatal Abril 18, 2019. https://www.uchile.cl/noticias/152974/spray-nasal-de-secretomas-revierte-dano-cerebral-por-asfixia-perinatal

Nota de prensa Diario Publimetro: La salvación para muchos: científicos de la Universidad de Chile crearon un spray nasal para combatir el alcoholismo. Agosto, 28, 2018. https://www.publimetro.cl/cl/noticias/2018/08/28/la-salvacion-muchos-cientificos-la-universidad-chile-crearon-spray-nasal-combatir-alcoholismo.html?fbclid=IwAR1vcPCQHDoulM4qePdJ0j7pk87cRfIkvyn8hdrwvgzDnXjDqRfj5tJocd8

Nota de prensa Noticias Universidad de Chile: Científicos de la U. de Chile crean spray nasal para el tratamiento del alcoholismo. http://www.uchile.cl/noticias/146492/cientificos-de-la-ude-chile-crean-spray-nasal-para-tratar-alcoholismo. Agosto, 28, 2018.

Entrevista radial ADN radio: Científicos de la U. de Chile crean spray nasal para combatir el alcoholismo
Para obtener buenos resultados, los investigadores experimentaron con células madres en ratas. Agosto, 28, 2018. https://www.adnradio.cl/noticias/sociedad/cientificos-de-la-u-de-chile-crean-spray-nasal-para-combatir-el-alcoholismo/20180828/nota/3791903.aspx

Participation in scientific meetings of the National Service for the Prevention and Rehabilitation of Drug and Alcohol Consumption-SENDA (Ministry of the Interior & Public Security, Chile) Consultant scientist (2015-2017)

Diario la Tercera, Tendencias Científicos chilenos logran frenar consumo excesivo de alcohol con células madre Noviembre, 11, 2016. https://www.latercera.com/noticia/cientificos-chilenos-logran-frenar-consumo-excesivo-alcohol-celulas-madre/

Project Supervision and Scientific Research Unit Liceo de Niñas No 1, Santiago Chile (Program directed by Prof. Roxana Nahuelcura) (3 students, 2, 3 and 4 medium) 2016

Conference Program 1000 scientists 1000 classrooms, Conycyt Explora. Students 3-4 media. New neurons implication in learning and brain repair. Evangelical Education Center of Hualpén, Concepción, Oct 7, 2016. Explora Conicyt.

Participation Explora -Conicyt Prog 1000 scientists 1000 classrooms 2010-2016

La Tercera Daily : Article Chilean scientists succeed in stoped excessive alcohol consumption with stem cells, 11-10.2016

Communication Website of the Faculty of Medicine, University of Chile. With stem cells they are able to stop excessive alcohol consumption, 10-11-2016

Presentation of the conference ICBM for schools students: new neurons: learning and brain repair Extension program School of Medicine, University of Chile 9-28-2016

Conference: Effects of dopamine on the postnatal neurogenesis Karolinska Institutet, Stockholm Sweden, July-2015

Conference: Effects of perinatal asphyxia on the postnatal neurogenesis at Karolinska Institutet, Stockholm Sweden Jun-2014

Internship in Karolinska Institutet, Lab Ernest Arenas July-August, 2015 International collaboration and dissemination. High-throughput primary dopamine cell cultures. Neurogenesis and dopamine.

Internship in Karolinska Institutet, Lab Tomas Hokfeld June-July, 2014 International collaboration and dissemination. Study of secretagogin in neurogenic regions. Effect of dopaminergic denervation.

Interview Faculty of Medicine How the brain is repaired after perinatal asphyxia, August, 2011

Lecture: Acute and long-term effects induced by perinatal asphyxia focusing in neurogenesis at Central Institute of Mental Health, Dept. of Psychopharmacology, Mannheim, Germany. March 2011.

Internship at the European Neuroscience Institute Göttingen, University Goettingen, Germany, Lab Andre Fischer, Epigenetics and laser capture. June-July 2012

Internship in ZI Mannheim, LabPeter Gebicke-Haerter, Rainer Spanaguel Epigenetic study of samples obtained from rats with perinatal asphyxia and controls at different ages. Evaluation by qPCR, ChIP and confocal microscopy June 7-July 8 2011

Conferences: Pathophysiology of perinatal asphyxia: can we predict and improve individual outcomes ?. ZI Mannheim

Lecture Neurogenesis and Perinatal Asphyxia: a therapeutic strategy at European Neuroscience Institute Göttingen, University Goettingen, Germany June 11, 2011.

Interview Bioplanet Magazine Perinatal asphyxia: Role of dopamine receptors November 2011

Postdoc fellowship in Canada in the laboratory of Professor R. Andrew Tasker, Department of Biomedical Sciences, University of Prince Edward Island, Charlottetown, PEI, Canada. Study of the branching of the mossy fibers of the dentate gyrus of the hippocampus. January, 2007



 

Article (50)

Administration of N-acetylcysteine Plus Acetylsalicylic Acid Markedly Inhibits Nicotine Reinstatement Following Chronic Oral Nicotine Intake in Female Rats
Innate gut microbiota predisposes to high alcohol consumption
Intranasal delivery of interferon-beta-loaded nanoparticles induces control of neuroinflammation in a preclinical model of multiple sclerosis: A promising simple, effective, non-invasive, and low-cost therapy
Neonatal Mesenchymal Stem Cell Treatment Improves Myelination Impaired by Global Perinatal Asphyxia in Rats.
Intranasal Administration of Mesenchymal Stem Cell Secretome Reduces Hippocampal Oxidative Stress, Neuroinflammation and Cell Death, Improving the Behavioral Outcome Following Perinatal Asphyxia
N-Acetylcysteine and Acetylsalicylic Acid Inhibit Alcohol Consumption by Different Mechanisms: Combined Protection
Oxidative Stress and Neuroinflammation as a Pivot in Drug Abuse. A Focus on the Therapeutic Potential of Antioxidant and Anti-Inflammatory Agents and Biomolecules
Activated mesenchymal stem cell administration inhibits chronic alcohol drinking and suppresses relapse-like drinking in high-alcohol drinker rats
Commonality of Ethanol and Nicotine Reinforcement and Relapse in Wistar-Derived UChB Rats: Inhibition by N-Acetylcysteine
Gold nanorods/siRNA complex administration for knockdown of PARP-1: A potential treatment for perinatal asphyxia
Intranasal delivery of mesenchymal stem cell-derived exosomes reduces oxidative stress and markedly inhibits ethanol consumption and post-deprivation relapse drinking.
Intravenous administration of anti-inflammatory mesenchymal stem cell spheroids reduces chronic alcohol intake and abolishes binge-drinking
Regionally Impaired Redox Homeostasis in the Brain of Rats Subjected to Global Perinatal Asphyxia: Sustained Effect up to 14 Postnatal Days
Acquisition, Maintenance and Relapse-Like Alcohol Drinking: Lessons from the UChB Rat Line
Intracerebral Stem Cell Administration Inhibits Relapse-like Alcohol Drinking in Rats
Modulation of Postnatal Neurogenesis by Perinatal Asphyxia: Effect of D-1 and D-2 Dopamine Receptor Agonists
Vulnerability to a Metabolic Challenge Following Perinatal Asphyxia Evaluated by Organotypic Cultures: Neonatal Nicotinamide Treatment
Effect of perinatal asphyxia on tuberomammillary nucleus neuronal density and object recognition memory: A possible role for histamine?
Models of progressive neurological dysfunction originating early in life
Perinatal Asphyxia Leads to PARP-1 Overactivity, p65 Translocation, IL-1 beta and TNF-alpha Overexpression, and Apoptotic-Like Cell Death in Mesencephalon of Neonatal Rats: Prevention by Systemic Neonatal Nicotinamide Administration
Salsolinol, free of isosalsolinol, exerts ethanol-like motivational/sensitization effects leading to increases in ethanol intake
Gene specific modifications unravel ethanol and acetaldehyde actions.
Further Studies on the Hypothesis of PARP-1 Inhibition as a Strategy for Lessening the Long-Term Effects Produced by Perinatal Asphyxia: Effects of Nicotinamide and Theophylline on PARP-1 Activity in Brain and Peripheral Tissue
Ethanol as a Prodrug: Brain Metabolism of Ethanol Mediates its Reinforcing Effects
Pathophysiology of perinatal asphyxia: can we predict and improve individual outcomes?
Pathophysiology of perinatal asphyxia: can we predict and improve individual outcomes?
Perinatal asphyxia: current status and approaches towards neuroprotective strategies, with focus on sentinel proteins
Comparison of the antidepressant sertraline on differential depression-like behaviors elicited by restraint stress and repeated corticosterone administration
Nicotinamide prevents the long-term effects of perinatal asphyxia on apoptosis, non-spatial working memory and anxiety in rats
Desipramine prevents stress-induced changes in depressive-like behavior and hippocampal markers of neuroprotection
Rat strain influences the use of egocentric learning strategies mediated by neostriatum
Acute perinatal asphyxia impairs non-spatial memory and alters motor coordination in adult male rats
Long lasting structural changes in primary motor cortex after motor skill learning: a behavioural and stereological study
Plasticity of hippocampus following perinatal asphyxia: Effects on postnatal apoptosis and neurogenesis.
Plasticity of hippocampus following perinatal asphyxia: effects on postnatal apoptosis and neurogenesis.
Exploring neurocircuitries of the basal ganglia by intracerebral administration of selective neurotoxins
Nicotinamide prevents the effect of perinatal asphyxia on dopamine release evaluated with in vivo microdialysis 3 months after birth
Perinatal asphyxia induces neurogenesis in hippocampus: an organotypic culture study
Plasticity of basal ganglia neurocircuitries following perinatal asphyxia: effect of nicotinamide
Adrenalectomy promotes a permanent decrease of plasma corticoid levels and a transient increase of apoptosis and the expression of Transforming Growth Factor ?1 (TGF-?1) in hippocampus: Effect of a TGF-?1 oligo-antisense
Effects of long-term adrenalectomy on apoptosis and neuroprotection in the rat hippocampus
Plasticity of the central nervous system (CNS) following perinatal asphyxia: Does nicotinamide provide neuroprotection?
Spatial cognition and memory: a reversible lesion with lidocaine into the anteromedial/posterior parietal cortex (AM/PPC) affects differently working and long-term memory on two foraging tasks
Effects of perinatal asphyxia on cell proliferation and neuronal phenotype evaluated with organotypic hippocampal cultures
Effects of perinatal asphyxia on cell survival, neuronal phenotype and neurite growth evaluated with organotypic triple cultures
Perinatal asphyxia impairs connectivity and dopamine neurite branching in organotypic triple culture from rat substantia nigra, neostriatum and neocortex
Corticosterone differentially regulates bax, bcl-2 and bcl-x mRNA levels in the rat hippocampus
Methyl bromide decreases excitability without having immediate toxic effects in rat hippocampal CA1 neurons in vitro
Persistent neuronal density changes related to the establishment of a motor memory
Interleukin-1? does not increase synaptic inhibition in hippocampal CA3 pyramidal and dentate gyrus granule cells of the rat in vitro

Abstract (4)

KNOCKDOWN OF HCN CHANNELS INTO THE VENTRAL TEGMENTAL AREA REDUCES ETHANOL CONSUMPTION IN UCHB DRINKING RATS
MICROINJECTION OF AN ANTI-CATALASE SHRNA-CODING LENTIVIRAL VECTOR INTO BRAIN VENTRAL TEGMENTAL AREA (VTA) VIRTUALLY ABOLISHES ETHANOL INTAKE BY RATS BRED AS HIGH ALCOHOL DRINKERS
Acute and long-term neuronal loss induced by perinatal asphyxia: activation of pro-apoptotic, anti-apoptotic and sentinel proteins
Effect of poly(ADP-ribose) polymerase-1 (PARP-1) inhibition on metabolic insults occurring at birth: promises and limitations

BookWhole (1)

Short- and long-term consequences of perinatal asphyxia: Looking for neuroprotective strategies

Patent (3)

Pharmaceutical composition for the treatment of addiction to psychoactive substances and / or for the prevention of relapses to said addiction
Injectable or intranasal composition comprising unstimulated or preconditioned mesenchymal stem cells (MSC), culture media derived from preconditioned MSC or exosomes derived from their culture and excipients; and its use to reduce drug use or block relapse due to deprivation, in a person with addiction.
Composición inyectable o intranasal que comprende células madre mesenquimáticas sin estimular o precondicionadas, medios de cultivos derivados de MSC precondicionadas o exosomas derivados de su cultivo y excipientes; y su uso para reducir el consumo de drogas o bloquear recaída por privación en una persona con adicción

Proyecto (18)

Opioid addiction and associated cognitive damage: Inhibition by intranasal mesenchymal stem cell secretome administration
Mesenchymal stem cells-secretome provides protection in neonatal hypoxia-reoxygenation. Mechanisms and translational studies
MESENCHYMAL STEM CELLS-SECRETOME PROVIDES PROTECTION IN NEONATAL HYPOXIA-REOXYGENATION. MECHANISMS AND TRANSLATIONAL STUDIES
The Oxidative stress-neuroinflammation Synergy: Role in the perpetuation of alcohol intake and therapeutic avenues
THE OXIDATIVE STRESS-NEUROINFLAMMATION SYNERGY=> ROLE IN THE PERPETUATION OF ALCOHOL INTAKE.
NanolnmunoTerapia para esclerosis múltiple=> nueva estrategia terapéutlca para la entrega directa de inmunomoduladores en el sistema nervioso central.
ASPHYXIA AT BIRTH PRIMES CNS DEVELOPMENT AND INCREASES THE VULNERABILITY TO SUBSEQUENT POSTNATAL INSULTS
MODULATION OF NEUROGENESIS BY PERINATAL ASPHYXIA=> ROLE OF DOPAMINE AND REGULATORS OF G-PROTEINS (RGS)
Proyecto iniciativa Milenio Instituto Neurociencia
LONG-TERM CHANGES IN BRAIN NEUROCIRCUITRIES PRODUCED BY PERINATAL ASPHYXIA=> IS POLY(ADP-RIBOSE) POLYMERASE-1 (PARP-1) INHIBITION A STRATEGY FOR NEUROPROTECTION?
NEUROGENESIS POSTNATAL INDUCIDA POR INJURIAS CEREBRALES Y SU MODULACION POR VIAS DE SEÑALIZACION ASOCIADAS AL FACTOR DE CRECIMIENTO DE FIBROBLASTO BASICO (BFGF).
Effects of perinatal Asphyxia in the hippocampal Neurogenesis=> Basic fibroblast Growth factor bFGF modulation.
PLASTICITY OF THE CENTRAL NERVOUS SYSTEM=> EFFECTS OF PERINATAL ASPHYXIA AND METABOLIC INSULTS
MODULACION DE ACTIVIDAD NEURONAL INDUCIDA POR INTERLEUKINA-1 EN EL HIPOCAMPO.
MODULATION OF NEUROGENESIS BY PERINATAL ASPHYXIA: ROLE OF DOPAMINE AND REGULATORS OF G-PROTEINS (RGS)
NEUROGÉNESIS POSTNATAL INDUCIDA POR INJURIAS CEREBRALES Y SU MODULACIÓN POR VÍAS DE SEÑALIZACION ASOCIADAS AL FACTOR DE CRECIMIENTO DE FIBROBLASTO BASICO (bFGF).
Asphyxia at birth primes CNS development and increases the vulnerability to subsequent postnatal insults
Long-term changes in brain neurocircuitries produced by perinatal asphyxia: Is Poly (ADP-ribose) polimerase-1 (PARP-1) inhibition a strategy for neuroprotection?

Review (4)

Gene and cell therapy on the acquisition and relapse-like binge drinking in a model of alcoholism: translational options
Targeting Sentinel Proteins and Extrasynaptic Glutamate Receptors: a Therapeutic Strategy for Preventing the Effects Elicited by Perinatal Asphyxia?
Pharmacological models and approaches for pathophysiological conditions associated with hypoxia and oxidative stress
Perinatal asphyxia: CNS development and deficits with delayed onset
78
Paola Morales

Profesor Asociado

Programa Farmacología Molecular & Clínica, ICBM,

Universidad de Chile

Santiago, Chile

23
Mario Herrera-Marschitz

Profesor titular

Mol. & Clin. Pharmacology

UNIVERSIDAD DE CHILE, FACULTAD DE MEDICINA, PROGRAMA FARMACOLOGIA MOLECULAR & CLINICA, ICBM

Santiago, Chile

10
Fernando Ezquer

Full Professor

Center for Regenerative Medicine

Universidad del Desarrollo

Santiago, Chile

5
JENNY FIEDLER

LAB. NEUROPLASTICIDAD Y NEUROGENETICA. DEPTO BIOQUIMICA Y BIOLOGÍA MOLECULAR. FAC. CIENCIAS QUÍMICAS Y FARMACÉUTICAS. UNIVERSIDAD DE CHILE

Santiago, Chile

4
JAVIER BRAVO

PROFESOR ADJUNTO

INSTITUTO DE QUÍMICA

PONTIFICIA UNIVERSIDAD CATÓLICA DE VALPARAISO

VALPARAÍSO, Chile

4
Edgardo Rojas

Académico e Investigador

Ciencias Químicas y Biológicas

Universidad Bernardo OHiggins

Santiago, Chile

4
Maria Quintanilla

PROFESOR ASOCIADO

FARMACOLOGÍA MOLECULAR Y CLÍNICA

UNIVERSIDAD DE CHILE, FACULLTAD DE MEDICINA, INSTITUTO DE CIENCIAS BIOMÉDICAS, PROGRAMA DE FARMACOLOGÍA MOLECULAR Y CLÍNICA

Santiago, Chile

3
Lisette Leyton

Full Professor

Cell and Molecular Biology

FACULTAD DE MEDICINA UNIVERSIDAD DE CHILE

Santiago, Chile

3
Eduardo Karahanian

Académico Investigador

Facultad de Ciencias de la Salud

Universidad Autónoma de Chile

Santiago, Chile

2
Eduardo Ezquer

Director/Full Professor

Centro de Medicina Regenerativa

UNIVERSIDAD DEL DESARROLLO, FACULTAD DE MEDICINA, INSTITUTO DE CIENCIAS

Santiago, Chile

2
Eduardo Karahanian

Professor

INSTITUTO DE CIENCIAS BIOMEDICAS

UNIVERSIDAD AUTONOMA DE CHILE

Santiago, Chile

2
José Ulloa

Profesor asistente

Psicología

Universidad de Talca

Talca, Chile

2
Maria Olivares

Docente Investigador

Instituto de Ciencias e Innovación en Medicina

Universidad del Desarrollo

Santiago, Chile

2
Sergio Cárdenas

Coordinador de Investigación e investigador

Centro de Ingeniería y desarrollo sostenible

Universidad Central de Chile

Santiago, Chile

1
Gonzalo Cruz

UNIVERSIDAD DE VALPARAISO

VALPARAISO, Chile

1
Eyleen Araya

Academic

Chemical Sciences

Universidad Andres Bello

santiago, Chile

1
Rodrigo Castillo

Profesor Asistente

Medicina Interna Oriente

University of Chile

Santiago, Chile

1
Natalia Hassan

Coordinadora

Universidad Tecnológica Metropolitana

Santiago, Chile

1
Felipe Salech

Academic

Medicine

Universidad de Chile / Facultad de Medicina

Santiago, Chile

1
Marianne Buscaglia

Estudiante de Doctorado en Ciencias Biológicas, mención Genética Molecular y Microbiología

Genética Molecular y Microbiología

Pontificia Universidad Católica de Chile

Santiago, Chile

1
Ana Riveros

Profesor Asistente

Departamento de Química Farmacológica y Toxicológica

UNIVERSIDAD DE CHILE, FACULTAD DE CIENCIAS QUIMICAS Y FARMACÉUTICAS

Santiago, Chile

1
Ramón Sotomayor

Full Professor

Institute of Physiology

UNIVERSIDAD DE VALPARAÍSO, FACULTAD DE CIENCIAS, DEPARTAMENTO DE FISIOLOGÍA

Valparaíso, Chile

1
Emilio HERRERA

Full Professor

Faculty of Medicine, ICBM

Universidad de Chile

Santiago, Chile

1
Jorge Farias

Associate Professor A

Chemical Engineering

Universidad de La Frontera

Temuco, Chile

1
Marcela Hermoso

Full Professor

School of Medicine

UNIVERSIDAD DE CHILE

Santiago, Chile

1
Andrés Couve

Profesor Titular

Neurociencia

FACULTAD DE MEDICINA, UNIVERSIDAD DE CHILE

Santiago, Chile

1
Marcelo Kogan

Academico

Quimica Farmacologica y Toxicologica

UNIVERSIDAD DE CHILE, FACULTAD DE CIENCIAS QUÍMICAS Y FARMACÉUTICAS

Santiago, Chile

1
jose valdes

Profesor Asociado

Neurociencia

UNIVERSIDAD DE CHILE

Santiago, Chile

1
Yedy Israel

Profesor Titular

Farmacologia Molecular y Clinica

UNIVERSIDAD DE CHILE, FACULTAD DE CS QUIMICAS Y FARMACÉUTICAS, LAB. FARMACOTERAPIA GÉNICA

Santiago, Chile

1
Bruce Cassels

Profesor Titular

Departamento de Química

UNIVERSIDAD DE CHILE, FACULTAD DE CIENCIAS, DEPARTAMENTO DE QUÍMICA

Santiago, Chile

1
Hernan Lara

Profesor Titular

Bioquimica y Biologia Molecular

U DE CHILE, FAC CIENCIAS QUIMICAS Y FARMACÉUTICAS

Santiago, Chile

1
Pablo Berríos

Asistente de investigación

Universidad del Desarrollo

Santiago, Chile

1
Felipe Oyarzún

Profesor Asociado

Ciencias y Tecnología Farmacéuticas

UNIVERSIDAD DE CHILE

Santiago, Chile

1
Glauben Landskron

Academic Researcher

Escuela de Medicina

Universidad Finis Terrae

Santiago, Chile