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Hernan Enrique Lara Peñaloza

Profesor Titular

U DE CHILE, FAC CIENCIAS QUIMICAS Y FARMACÉUTICAS

Santiago, Chile

Líneas de Investigación


NEUROBIOCHEMISTRY; PHYSIOLOGY, PHARMACOLOGY; NEUROENDOCRINOLOGY; Reg neuroendocrina de la funcion ovarica y envejecimiento ovarico; Farmacologia endocrina; Fisiologi­a; Neuroendocrinologia

Educación

  •  Neuroendocrinologia, UNIVERSIDAD DE CHILE. Chile, 1985
  •  Neuroendocrinologia, UNIVERSIDAD DE CHILE. Chile, 1985

Experiencia Académica

  •   Profesor Titular Full Time

    UNIVERSIDAD DE CHILE

    Ciencias Quimicas y Farmaceuticas

    Santiago, Chile

    1978 - A la fecha


 

Article (35)

Effect of Superior Ovarian Nerve and Plexus Nerve Sympathetic Denervation on Ovarian-Derived Infertility Provoked by Estradiol Exposure to Rats
Role of ovarian sympathetic nerves and cholinergic local system during cold stress
High-Frequency Electrical Modulation of the Superior Ovarian Nerve as a Treatment of Polycystic Ovary Syndrome in the Rat.
Neonatal exposure to estradiol valerate reprograms the rat ovary androgen receptor and anti-Müllerian hormone to a polycystic ovary phenotype.
Role of RFRP-3 in the development of cold stress-induced polycystic ovary phenotype in rats
Developmental and Functional Effects of Steroid Hormones on the Neuroendocrine Axis and Spinal Cord.
In vivo blockade of acetylcholinesterase increases intraovarian acetylcholine and enhances follicular development and fertility in the rat.
In vivo blockade of acetylcholinesterase increases intraovarian acetylcholine and enhances follicular development and fertility in the rat.
Kisspeptin is involved in ovarian follicular development during aging in rats.
Postnatal administration of allopregnanolone modifies glutamate release but not BDNF content in striatum samples of rats prenatally exposed to ethanol.
Readthrough acetylcholinesterase (AChE-R) and regulated necrosis: pharmacological targets for the regulation of ovarian functions?
Dopamine in human follicular fluid is associated with cellular uptake and metabolism-dependent generation of reactive oxygen species in granulosa cells: implications for physiology and pathology
Estrous cycle disruptor effect of an ethanolic extract from Buddleja globosa leaves and its main component (verbascoside)
Estrous cycle disruptor effect of an ethanolic extract from Buddleja globosa leaves and its main component (verbascoside) [Efecto disruptor del ciclo estral de un extracto etanólico de hojas de Buddleja globosa y de su componente principal (verbascósido)]
Long-term impact of early life events on physiology and behaviour.
Placental steroidogenesis in pregnant women with polycystic ovary syndrome.
Transitory activation of the central and ovarian norepinephrine systems during cold stress-induced polycystic ovary in rats.
Blocking of beta-Adrenergic Receptors During the Subfertile Period Inhibits Spontaneous Ovarian Cyst Formation in Rats
Evidence for a Celiac Ganglion-Ovarian Kisspeptin Neural Network in the Rat: Intraovarian Anti-Kisspeptin Delays Vaginal Opening and Alters Estrous Cyclicity
In Vivo beta-Adrenergic Blockade by Propranolol Prevents Isoproterenol-induced Polycystic Ovary in Adult Rats
Targeting Serous Epithelial Ovarian Cancer with Designer Zinc Finger Transcription Factors
Temporal window in which exposure to estradiol permanently modifies ovarian function causing polycystic ovary morphology in rats
Beta(2)-adrenergic receptor regulates cardiac fibroblast autophagy and collagen degradation
Expression of melanocortin receptors mRNA, and direct effects of ACTH on steroid secretion in the bovine ovary.
Neonatal exposure to single doses of estradiol or testosterone programs ovarian follicular development-modified hypothalamic neurotransmitters and causes polycystic ovary during adulthood in the rat.
Sympathetic nerve activity in normal and cystic follicles from isolated bovine ovary: local effect of beta-adrenergic stimulation on steroid secretion.
Cold-induced glutamate release in vivo from the magnocellular region of the paraventricular nucleus is involved in ovarian sympathetic activation.
Chronic-intermittent cold stress in rats induces selective ovarian insulin resistance.
Increases in norepinephrine release and ovarian cyst formation during ageing in the rat.
Testosterone-induced downregulation of anti-Müllerian hormone expression in granulosa cells from small bovine follicles.
Catecholamine uptake, storage, and regulated release by ovarian granulosa cells.
Locus coeruleus mediates cold stress-induced polycystic ovary in rats.
Effects of long-term adrenalectomy on apoptosis and neuroprotection in the rat hippocampus
Distinct protein kinases regulate SNAP-25 expression in chromaffin cells
Multiple calcium pathways induce the expression of SNAP-25 protein in chromaffin cells

Abstract (3)

Gestational sympathetic stress decreases noradrenaline placental transporter an program the offspring fertility, a third generation study
Acetylcholinesterase in the ovary
NGF increases the expression of VEGF in epithelial ovarian carcinoma.

EditorialMaterial (2)

Neuroendocrine Regulation and Homeostasis
Advances in Neuroendocrine Mechanisms

Proyecto (18)

AUTONOMIC NEURAL CONTROL OF OVARY FUNCTION. PARTICIPATION IN THE POLYCYSTIC OVARY DEVELOPMENT AND FERTILITY
NEUROENDOCRINE REGULATION OF THE RAT OVARY=> PRENATAL EXPOSURE TO SYMPATHETIC STRESS AND ITS TRANSGENERATIONAL EFFECTS ON THE REPRODUCTIVE FUNCTION OF THE PROGENY.
PARTICIPATION OF KISSPEPTIN AND THE SYMPATHETIC NERVOUS SYSTEM IN THE OVARIAN FOLLICULAR DEVELOPMENT OF THE RAT DURING REPRODUCTIVE AGING.
Role of Acetylcholine and Acetylcholine esterasa in the development of the polycystic ovarian syndrome (PCOS) – rat model and human granulosa cells
REPRODUCTIVE AND METABOLIC FEATURES DURING THE MENOPAUSAL TRANSITION AND THE EARLY POSTMENOPAUSAL PERIOD IN WOMEN WITH POLYCYSTIC OVARY SYNDROME (PCOS)=> DEEPENING INTO THE PATHOPHYSIOLOGY OF PCOS.
NEONATAL EXPOSURE TO ESTRADIOL AND STRESS IN RATS, ACTIVATES NEURAL GENES AND PROGRAMS SYMPATHETIC NERVE ACTIVITY TO DETERMINE CHANGES IN REPRODUCTIVE FUNCTION AND POLYCYSTIC OVARY DEVELOPMENT.
PARTICIPACION DE LA ACTIVIDAD NERVIOSA EXTRINSECA E INTRINSECA EN EL CONTROL DEL TERMINO DE LA FUNCION OVARICA
EVALUACION DE LA FUNCION Y RESERVA OVARICA EN HIJAS DE MUJERES CON SINDROME DE OVARIO POLIQUISTICO=> POSIBLE IMPACTO DEL AMBIENTE PRENATAL
CAMBIOS EN LA ACTIVIDAD NERVIOSA SIMPATICA DURANTE EL DESARROLLO NEONATAL PREDISPONE EL OVARIO POLIQUISTICO EN LA VIDA ADULTA.
CAMBIOS EN LA ACTIVIDAD NERVIOSA SIMPATICA DURANTE EL DESARROLLO NEONATAL PREDISPONE EL OVARIO POLIQUISTICO EN LA VIDA ADULTA.
MARCADORES MOLECULARES COMO ELEMENTOS PREDICTIVOS TEMPRANOS DE LA EFICACIA DEL TRATAMIENTO CON ANTIDEPRESIVOS
PARTICIPACION DEL FACTOR DE CRECIMIENTO NERVIOSO(NGF) Y SU RELACION CON EL FACTOR DE CRECIMIENTO DEL EPITELIO VASCULAR(VEGF) EN LA ANGIOGENESIS DEL OVARIO. ESTUDIO EN OVARIO NORMAL Y CANCER EPITELIAL
REGULACION NEUROENDOCRINA DE LA FUNCION OVARICA. ESTUDIOS DE LOS MECANISMOS CENTRALES Y PERIFERICOS QUE PARTICIPAN EN LOS CAMBIOS DE LA ACTIVIDAD NERVIOSA SIMPATICA RESPONSABLES DE LA FORMACION DE OVARIO POLIQUISTICO
REGULACION NEUROENDOCRINA DE LA FUNCION OVARICA. PARTICIPACION DE LAS NEUROTROFINAS EN LA FORMACION DE QUISTES OVARICOS INDUCIDOS POR CAMBIOS EN LA ACTIVIDAD DE LOS NERVIOS SIMPATICOS
REGULACION DE LA FUNCION OVARICA POR CAMBIOS EN LA ACTIVIDAD DE LOS NERVIOS SIMPATICOS. ESTUDIOS BIOQUIMICOS Y MOLECULARES SOBRE SU PARTICIPACION EN EL DESARROLLO O MANTENCION DEL OVARIO POLIQUISTICO.
ESTUDIOS NEUROENDOCRINOS Y MOLECULARES SOBRE LA PARTICIPACION NERVIOSA EN EL DESARROLLO DEL SINDROME DEL OVARIO POLIOUISTICO
PARTICIPACION DEL NEUROPEPTIDO TIROSINA (NPY) EN LA NEUROTRANSMISION CATECOLAMINERGICA CENTRAL Y PERIFERICA
INFLUENCIAS NEUROENDOCRINAS EN EL OVARIO POLIQUISTICO. ESTUDIOS NEUROQUIMICOS EN LA RATA.

Review (2)

Stress and the Reproductive Axis
Hormonal Programming Across the Lifespan
23
Hernan Lara

Profesor Titular

Bioquimica y Biologia Molecular

U DE CHILE, FAC CIENCIAS QUIMICAS Y FARMACÉUTICAS

Santiago, Chile

3
Alfonso Paredes

UNIVERSIDAD DE CHILE

Santiago, Chile

2
Sergio Lavandero

Director

Advanced Center for Chronic Diseases (ACCDiS)

UNIVERSIDAD DE CHILE, FAC CIENCIAS QUÍMICAS Y FARMACÉUTICAS

Santiago, Chile

2
Rodrigo Troncoso

Assistant professor

Universidad de Chile, Instituto de Nutrición y Tecnología de los Alimentos

Santiago de Chile, Chile

2
Carmen Romero

Jefe Laboratorio Endocrinología y Biología Reproductiva

Obstetricia y Ginecología

HOSPITAL CLÍNICO UNIVERSIDAD DE CHILE

Santiago, Chile

2
Carla Delporte

Profesor titular

Química Farmacológica y Toxicológica

UNIVERSIDAD DE CHILE, FACULTAD CIENCIAS QUÍMICAS Y FARMACÉUTICAS

SANTIAGO, Chile

1
DONALD BROWN

PROFESOR TITULAR

FACULTAD DE CIENCIAS

UNIVERSIDAD DE VALPARAÍSO

Valparaíso, Chile

1
Rodrigo Troncoso

Associate Professor

Instituto de Nutrición y Tecnología de los Alimentos

Santiago, Chile

1
Ramón Sotomayor

Full Professor

Institute of Physiology

UNIVERSIDAD DE VALPARAÍSO, FACULTAD DE CIENCIAS, DEPARTAMENTO DE FISIOLOGÍA

Valparaíso, Chile

1
Pablo Aránguiz

Postdoctorado

Fisiología y Biofísica

Universidad de Chile

Santiago, Chile

1
rafael barra

Academico investigador

Escuela de Medicina

universidad de santiago de Chile

Santiago de Chile, Chile

1
Gonzalo Cruz

UNIVERSIDAD DE VALPARAISO

VALPARAISO, Chile

1
Sergio Cárdenas

Coordinador de Investigación e investigador

Centro de Ingeniería y desarrollo sostenible

Universidad Central de Chile

Santiago, Chile

1
Miguel del Campo

Investigador Adjunto Proyecto FONDECYT 151337

Fundación Ciencia y Tecnología para el Desarrollo

Santiago, Chile

1
JENNY FIEDLER

LAB. NEUROPLASTICIDAD Y NEUROGENETICA. DEPTO BIOQUIMICA Y BIOLOGÍA MOLECULAR. FAC. CIENCIAS QUÍMICAS Y FARMACÉUTICAS. UNIVERSIDAD DE CHILE

Santiago, Chile

1
Paola Morales

Profesor Asociado

Programa Farmacología Molecular & Clínica, ICBM,

Universidad de Chile

Santiago, Chile

1
JAVIER BRAVO

PROFESOR ADJUNTO

INSTITUTO DE QUÍMICA

PONTIFICIA UNIVERSIDAD CATÓLICA DE VALPARAISO

VALPARAÍSO, Chile

1
Selva Luna

Profesor Titular

Facultad de Farmacia

Universidad de Valparaíso

VALPARAISO, Chile