Man

Alfonso Humberto Paredes Vargas

UNIVERSIDAD DE CHILE

Santiago, Chile

Líneas de Investigación


Fisiología; Neuroendocrinologia; NEUROBIOCHEMISTRY; PHYSIOLOGY, PHARMACOLOGY; NEUROENDOCRINOLOGY; Farmacología molecular cardiovascular; fibrosis cardiaca; patologías cardiovascular; regulación neuroendocrina de la función ovárica; regulación neuroendocrina del envejecimiento ovarico


 

Article (41)

Effects of sympathectomy on ovarian follicular development and steroid secretion.
Ovarian function and reproductive senescence in the rat=> role of ovarian sympathetic innervation.
Ovarian function and reproductive senescence in the rat=> role of ovarian sympathetic innervation.
Kisspeptin is involved in ovarian follicular development during aging in rats
Kisspeptin is involved in ovarian follicular development during aging in rats.
Peripheral and Central Mechanisms Involved in the Hormonal Control of Male and Female Reproduction.
Maternal sympathetic stress impairs follicular development and puberty of the offspring
Ovarian localization of 11-beta-Hydroxysteroid Dehydrogenase (11-beta-HSD): Effects of ACTH stimulation and its relationship with bovine cystic ovarian disease.
Blocking of beta-Adrenergic Receptors During the Subfertile Period Inhibits Spontaneous Ovarian Cyst Formation in Rats
Blocking of beta-adrenergic receptors during the subfertile period inhibits spontaneous ovarian cyst formation in rats.
Evidence for a Celiac Ganglion-Ovarian Kisspeptin Neural Network in the Rat: Intraovarian Anti-Kisspeptin Delays Vaginal Opening and Alters Estrous Cyclicity
Evidence for a celiac ganglion-ovarian kisspeptin neural network in the rat: intraovarian anti-kisspeptin delays vaginal opening and alters estrous cyclicity.
Hormonal programming across the lifespan.
Expression of melanocortin receptors mRNA, and direct effects of ACTH on steroid secretion in the bovine ovary
Neurotrophins acting via TRKB receptors activate the JAGGED1-NOTCH2 cell-cell communication pathway to facilitate early ovarian development.
Neurotrophins acting via TRKB receptors activate the JAGGED1-NOTCH2 cell-cell communication pathway to facilitate early ovarian development.
Sympathetic nerve activity in normal and cystic follicles from isolated bovine ovary: local effect of beta-adrenergic stimulation on steroid secretion.
Tyrosine kinase A receptor (trkA): A potential marker in epithelial ovarian cancer
Excessive Ovarian Production of Nerve Growth Factor Facilitates Development of Cystic Ovarian Morphology in Mice and Is a Feature of Polycystic Ovarian Syndrome in Humans
Increases in norepinephrine release and ovarian cyst formation during ageing in the rat.
Increases in norepinephrine release and ovarian cyst formation during ageing in the rat.
NTRK1 and NTRK2 receptors facilitate follicle assembly and early follicular development in the mouse ovary
Catecholamine uptake, storage, and regulated release by ovarian granulosa cells
Fbxw15/Fbxo12J is an F-box protein-encoding gene selectively expressed in oocytes of the mouse ovary.
Functional development of the ovarian noradrenergic innervation
Neonatal exposure to estradiol valerate programs ovarian sympathetic innervation and follicular development in the adult rat
Loss of synaptonemal complex protein-1, a synaptonemal complex protein, contributes to the initiation of follicular assembly in the developing rat ovary
Loss of synaptonemal complex protein-1, a synaptonemal complex protein, contributes to the initiation of follicular assembly in the developing rat ovary.
Role of stress and sympathetic innervation in the development of polycystic ovary syndrome
TrkB receptors are required for follicular growth and oocyte survival in the mammalian ovary
alpha(2)-adrenoceptors control the release of noradrenaline but not neuropeptide Y from perivascular nerve terminals
Nerve growth factor induces the expression of functional FSH receptors in newly formed follicles of the rat ovary
Neurotrophic control of ovarian development
A conditional tetracycline-regulated increase in Gamma amino butyric acid production near luteinizing hormone-releasing hormone nerve terminals disrupts estrous cyclicity in the rat.
Adrenalectomy regulates apoptotic-associated genes in rat hippocampus
An increased intraovarian synthesis of nerve growth factor and its low affinity receptor is a principal component of steroid-induced polycystic ovary in the rat
Intraovarian excess of nerve growth factor increases androgen secretion and disrupts estrous cyclicity in the rat
Effects of adrenalectomy on the stress-induced changes in ovarian sympathetic tone in the rat.
Rise in endothelium-derived NO after stimulation of rat perivascular sympathetic mesenteric nerves.
Stress promotes development of ovarian cysts in rats: the possible role of sympathetic nerve activation.
Kisspeptin levels in rat ovary during aging is regulated by the sympathetic nervous system.

Proyecto (11)

Autonomic neural control of ovary function. Participation in the polycystic ovary development and fertility
Ovarian Sympathetic nerve and its activity in modulating infertility during aging..
Neuroendocrine regulation of the rat ovary. Prenatal exposure to sympathetic stress and its transgenerational effects on the reproductive function of the progeny
Participation of kisspeptin and the sympathetic nervous system in the ovarian follicular development of the rat during reproductive aging
Contribution of TrkA receptor isoforms to the cellular proliferation and angiogenesis of epithelial ovarian cancer=> potential targets for therapeutic intervention.
Participación de la Acetilcolina y de la Acetilcolinoesterasa en el desarrollo del síndrome de ovario poliquístico (PCOS)=> estudios en modelos maurinos y en células granulosa humana
Neonatal exposure to estradiol and stress in rats, activates neural genes and programs sympathetic nerve activity to determine changes in reproductive function and...
Participación de la actividad nerviosa extrínseca e intrínseca en el control del término de la función ovárica. Investigador Principal.
Participación del receptor trkA y su ligando, el factor de crecimiento nervioso (NGF), en la génesis y progresión del cáncer ovárico epitelial
Participación del factor de crecimiento neuronal (NGF) y el receptor de baja afinidad p75NTR en el desarrollo folicular ovárico al término del período reproductivo
Cambios en la actividad nerviosa simpática durante el desarrollo neonatal predispone el ovario poliquístico en la vida adulta

Review (2)

Long-Term Effects of Early-Life Exposure to Environmental Oestrogens on Ovarian Function: Role of Epigenetics
Hormonal Programming Across the Lifespan
21
Alfonso Paredes

UNIVERSIDAD DE CHILE

Santiago, Chile

17
Alfonso Paredes

Investigador principal

Bioquímica y Biología Molecular

University of Chile / Faculty of Chemical Sciences and Pharmacy

Santiago, Chile

4
Carmen Romero

Jefe Laboratorio Endocrinología y Biología Reproductiva

Obstetricia y Ginecología

HOSPITAL CLÍNICO UNIVERSIDAD DE CHILE

Santiago, Chile

3
Hernan Lara

Profesor Titular

Bioquimica y Biologia Molecular

U DE CHILE, FAC CIENCIAS QUIMICAS Y FARMACÉUTICAS

Santiago, Chile

2
Gonzalo Cruz

UNIVERSIDAD DE VALPARAISO

VALPARAISO, Chile

1
Maria Vega

Academico Profesora Titular

Obstetricia y Ginecologia Campus Norte

UNIVERSIDAD DE CHILE - FACULTAD DE MEDICINA

Santiago, Chile

1
Bredford Kerr

Profesor Asociado

CEBICEM

Universidad San Sebastián

Santiago, Chile

1
Ramón Sotomayor

Full Professor

Institute of Physiology

UNIVERSIDAD DE VALPARAÍSO, FACULTAD DE CIENCIAS, DEPARTAMENTO DE FISIOLOGÍA

Valparaíso, Chile

1
Andres Carvajal

Investigador

INIA

Osorno, Chile

1
rafael barra

Academico investigador

Escuela de Medicina

universidad de santiago de Chile

Santiago de Chile, Chile

1
JAVIER BRAVO

PROFESOR ADJUNTO

INSTITUTO DE QUÍMICA

PONTIFICIA UNIVERSIDAD CATÓLICA DE VALPARAISO

VALPARAÍSO, Chile

1
Sergio Cárdenas

Coordinador de Investigación e investigador

Centro de Ingeniería y desarrollo sostenible

Universidad Central de Chile

Santiago, Chile