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Alfonso Humberto Paredes Vargas

UNIVERSIDAD DE CHILE

Santiago, Chile

FisiologÃa; Neuroendocrinologia; NEUROBIOCHEMISTRY; PHYSIOLOGY, PHARMACOLOGY; NEUROENDOCRINOLOGY; FarmacologÃa molecular cardiovascular; fibrosis cardiaca; patologÃas cardiovascular; regulaciÃ³n neuroendocrina de la funciÃ³n ovÃ¡rica; regulaciÃ³n neuroendocrina del envejecimiento ovarico


Effects of sympathectomy on ovarian follicular development and steroid secretion. Garrido, Maritza P; Fernandois, Daniela; Venegas, Mauricio; Paredes, Alfonso H Article Reproduction (Cambridge, England) (2018)
Ovarian function and reproductive senescence in the rat=> role of ovarian sympathetic innervation. Cruz, Gonzalo; Fernandois, Daniela; Paredes, Alfonso H Article Reproduction (Cambridge, England) (2017)
Ovarian function and reproductive senescence in the rat=> role of ovarian sympathetic innervation. Cruz, G; Fernandois, D; Paredes, A. Article REPRODUCTION (2017)
Kisspeptin is involved in ovarian follicular development during aging in rats Fernandois, D; Na, E; Cuevas, F; Cruz, G; Lara, HE; Paredes, AH. Article JOURNAL OF ENDOCRINOLOGY (2016)
Kisspeptin is involved in ovarian follicular development during aging in rats. Fernandois, D; Na, E; Cuevas, F; Cruz, G; Lara, H E; Paredes, A H Article The Journal of endocrinology (2016)
Peripheral and Central Mechanisms Involved in the Hormonal Control of Male and Female Reproduction. Rudolph, L M; Bentley, G E; Calandra, R S; Paredes, A H; Tesone, M; Wu, T J; Micevych, P E Article Journal of neuroendocrinology (2016)
Maternal sympathetic stress impairs follicular development and puberty of the offspring Barra, R; Cruz, G.; Mayerhofer A.; Paredes A.; Lara, HE Article ISI SCOPUS REPRODUCTION (2014)
Ovarian localization of 11-beta-Hydroxysteroid Dehydrogenase (11-beta-HSD): Effects of ACTH stimulation and its relationship with bovine cystic ovarian disease. Amweg AN, Salvettia NR, Stangaferro ML, Paredes AH, Lara HE, Rodrígueza FM. Ortega HH. Article Domestic Animal Endocrinology (2013)
Blocking of beta-Adrenergic Receptors During the Subfertile Period Inhibits Spontaneous Ovarian Cyst Formation in Rats Fernandois, D; Lara H.E.; Paredes A.H. Article ISI SCOPUS Hormone and Metabolic Research (2012)
Blocking of beta-adrenergic receptors during the subfertile period inhibits spontaneous ovarian cyst formation in rats. Fernandois D, Lara HE, Paredes AH Article Horm Metab Res (2012)
Evidence for a Celiac Ganglion-Ovarian Kisspeptin Neural Network in the Rat: Intraovarian Anti-Kisspeptin Delays Vaginal Opening and Alters Estrous Cyclicity Ricu M.A.; Ramirez V.D.; Paredes A.H.; Lara H.E. Article ISI SCOPUS Endocrinology (2012)
Evidence for a celiac ganglion-ovarian kisspeptin neural network in the rat: intraovarian anti-kisspeptin delays vaginal opening and alters estrous cyclicity. Ricu, Manuel A; Ramirez, Victor D; Paredes, Alfonso H; Lara, Hernan E Article Endocrinology (2012)
Hormonal programming across the lifespan. Nugent, B M; Tobet, S A; Lara, H E; Lucion, A B; Wilson, M E; Recabarren, S E; Paredes, A H Article Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et meÌ�tabolisme (2012)
Expression of melanocortin receptors mRNA, and direct effects of ACTH on steroid secretion in the bovine ovary Amweg, AN; Paredes A.; Salvetti, NR; Lara, HE; Ortega, HH Article ISI SCOPUS Theriogenology (2011)
Neurotrophins acting via TRKB receptors activate the JAGGED1-NOTCH2 cell-cell communication pathway to facilitate early ovarian development. Dorfman,M=> Kerr; B, Garcia-Rudaz; C, Paredes; AH, Dissen; GA, Ojeda SR. Article ENDOCRINOLOGY (2011)
Neurotrophins acting via TRKB receptors activate the JAGGED1-NOTCH2 cell-cell communication pathway to facilitate early ovarian development. Dorfman, Mauricio D; Kerr, Bredford; Garcia-Rudaz, Cecilia; Paredes, Alfonso H; Dissen, Gregory A; Ojeda, Sergio R Article Endocrinology (2011)
Sympathetic nerve activity in normal and cystic follicles from isolated bovine ovary: local effect of beta-adrenergic stimulation on steroid secretion. Paredes, Alfonso H; Salvetti, Natalia R; Diaz, Ariel E; Dallard, Bibiana E; Ortega, Hugo H; Lara, Hernan E Article Reproductive biology and endocrinology : RB&E (2011)
Tyrosine kinase A receptor (trkA): A potential marker in epithelial ovarian cancer Tapia, V; Gabler F.; Munoz M.; Yazigi R.; Paredes A.; Selman A.; Vega M.; Romero C. Article ISI SCOPUS Gynecologic Oncology (2011)
Excessive Ovarian Production of Nerve Growth Factor Facilitates Development of Cystic Ovarian Morphology in Mice and Is a Feature of Polycystic Ovarian Syndrome in Humans Dissen, GA; Garcia-Rudaz, C; Paredes A.; Mayer C.; Mayerhofer A.; Ojeda, SR Article ISI SCOPUS ENDOCRINOLOGY (2009)
Increases in norepinephrine release and ovarian cyst formation during ageing in the rat. Acuña, Eric; Fornes, Romina; Fernandois, Daniela; Garrido, Maritza P; Greiner, Monika; Lara, Hernan E; Paredes, Alfonso H Article Reproductive biology and endocrinology : RB&E (2009)
Increases in norepinephrine release and ovarian cyst formation during ageing in the rat. Acuña, E; Fornes, R; Fernandois, D; Garrido, MP; Greiner, M; Lara, HE; Paredes, AH. Article Reproductive Biology and Endocrinology (2009)
NTRK1 and NTRK2 receptors facilitate follicle assembly and early follicular development in the mouse ovary Kerr, B.; Garcia-Rudaz, C; Dorfman, M; Paredes A.; Ojeda, SR Article ISI SCOPUS REPRODUCTION (2009)
Catecholamine uptake, storage, and regulated release by ovarian granulosa cells Greiner M.; Paredes A.; Rey-Ares, V; Saller, S; Mayerhofer A.; Lara, HE Article ISI SCOPUS ENDOCRINOLOGY (2008)
Fbxw15/Fbxo12J is an F-box protein-encoding gene selectively expressed in oocytes of the mouse ovary. De La Chesnaye, Elsa; Kerr, Bredford; Paredes, Alfonso; Merchant-Larios, Horacio; Méndez, Juan Pablo; Ojeda, Sergio R Article Biology of reproduction (2008)
Functional development of the ovarian noradrenergic innervation Ricu, M; Paredes A.; Greiner M.; Ojeda, SR; Lara, HE Article ISI SCOPUS ENDOCRINOLOGY (2008)
Neonatal exposure to estradiol valerate programs ovarian sympathetic innervation and follicular development in the adult rat Sotomayor-Zarate, R; Dorfman, M; Paredes A.; Lara, HE Article ISI SCOPUS BIOLOGY OF REPRODUCTION (2008)
Loss of synaptonemal complex protein-1, a synaptonemal complex protein, contributes to the initiation of follicular assembly in the developing rat ovary Paredes A.; Garcia-Rudaz, C; Kerr, B.; Tapia, V; Dissen G.A.; Costa M.E.; Cornea A.; Ojeda S.R. Article ISI SCOPUS ENDOCRINOLOGY (2005)
Loss of synaptonemal complex protein-1, a synaptonemal complex protein, contributes to the initiation of follicular assembly in the developing rat ovary. Paredes, Alfonso; Garcia-Rudaz, Cecilia; Kerr, Bredford; Tapia, Veronica; Dissen, Gregory A; Costa, Maria E; Cornea, Anda; Ojeda, Sergio R Article Endocrinology (2005)
Role of stress and sympathetic innervation in the development of polycystic ovary syndrome Greiner M.; Paredes A.; Araya, V; Lara, HE Article ISI SCOPUS ENDOCRINE (2005)
TrkB receptors are required for follicular growth and oocyte survival in the mammalian ovary Paredes A.; Romero C.; Dissen G.A.; Cornea A.; Ojeda S.R.; DeChiara T.M.; Reichardt L.; Xu, B. Article SCOPUS DEVELOPMENTAL BIOLOGY (2004)
alpha(2)-adrenoceptors control the release of noradrenaline but not neuropeptide Y from perivascular nerve terminals Donoso, MV; Carvajal A.; Paredes A.; Tomic A.; Koenig, CS; Huidobro-Toro, JP Article ISI SCOPUS PEPTIDES (2002)
Nerve growth factor induces the expression of functional FSH receptors in newly formed follicles of the rat ovary Paredes A.; Dissen G.A.; Ojeda S.R.; Romero C. Article SCOPUS ENDOCRINOLOGY (2002)
Neurotrophic control of ovarian development Dissen, GA; Romero C.; Paredes A.; Ojeda, SR Article ISI MICROSCOPY RESEARCH AND TECHNIQUE (2002)
A conditional tetracycline-regulated increase in Gamma amino butyric acid production near luteinizing hormone-releasing hormone nerve terminals disrupts estrous cyclicity in the rat. Bilger, M; Heger, S; Brann, D W; Paredes, A; Ojeda, S R Article Endocrinology (2001)
Adrenalectomy regulates apoptotic-associated genes in rat hippocampus Greiner M.; Cardenas, S; Parra C.; Bravo, J.; Avalos, AM; Paredes A.; Lara, HE; Fiedler, JL Article ISI SCOPUS ENDOCRINE (2001)
An increased intraovarian synthesis of nerve growth factor and its low affinity receptor is a principal component of steroid-induced polycystic ovary in the rat Lara, HE; Dissen, GA; Leyton, V; Paredes A.; Fuenzalida H.; Fiedler, JL; Ojeda, SR Article ISI SCOPUS ENDOCRINOLOGY (2000)
Intraovarian excess of nerve growth factor increases androgen secretion and disrupts estrous cyclicity in the rat Dissen, GA; Lara, HE; Leyton, V; Paredes A.; Hill, DF; Costa, ME; Martinez-Serrano, A; Ojeda, SR Article ISI SCOPUS ENDOCRINOLOGY (2000)
Effects of adrenalectomy on the stress-induced changes in ovarian sympathetic tone in the rat. Gálvez, A; Paredes, A; Fiedler, J L; Venegas, M; Lara, H E Article Endocrine (1999)
Rise in endothelium-derived NO after stimulation of rat perivascular sympathetic mesenteric nerves. Boric, M P; Figueroa, X F; Donoso, M V; Paredes, A; Poblete, I; Huidobro-Toro, J P Article The American journal of physiology (1999)
Stress promotes development of ovarian cysts in rats: the possible role of sympathetic nerve activation. Paredes, A; Gálvez, A; Leyton, V; Aravena, G; Fiedler, J L; Bustamante, D; Lara, H E Article Endocrine (1998)
Kisspeptin levels in rat ovary during aging is regulated by the sympathetic nervous system. Daniela Fernandois, Gonzalo Cruz, Eun Kyung Na, Hernán E. Lara and Alfonso H. Paredes Article JOURNAL OF ENDOCRINOLOGY (0)


Autonomic neural control of ovary function. Participation in the polycystic ovary development and fertility FONDECYT (1170291) Proyecto 2017-2020 Coinvestigador(a)
Ovarian Sympathetic nerve and its activity in modulating infertility during aging.. glaxosmithkline (2014-560) Proyecto 2014-2015 Inv. Responsable
Neuroendocrine regulation of the rat ovary. Prenatal exposure to sympathetic stress and its transgenerational effects on the reproductive function of the progeny FONDECYT (1130039) Proyecto 2013-2016 Coinvestigador(a)
Participation of kisspeptin and the sympathetic nervous system in the ovarian follicular development of the rat during reproductive aging FONDECYT (1120147) Proyecto 2012-2014 Inv. Responsable
Contribution of TrkA receptor isoforms to the cellular proliferation and angiogenesis of epithelial ovarian cancer=> potential targets for therapeutic intervention. FONDECYT (1110372) Proyecto 2011-2014 Coinvestigador(a)
Participación de la Acetilcolina y de la Acetilcolinoesterasa en el desarrollo del síndrome de ovario poliquístico (PCOS)=> estudios en modelos maurinos y en células granulosa humana PIA (DFG-10) Proyecto 2011-2012 Coinvestigador(a)
Neonatal exposure to estradiol and stress in rats, activates neural genes and programs sympathetic nerve activity to determine changes in reproductive function and... FONDECYT (1090036) Proyecto 2009-2013 Coinvestigador(a)
Participación de la actividad nerviosa extrínseca e intrínseca en el control del término de la función ovárica. Investigador Principal. FONDECYT (1090159) Proyecto 2009-2012 Inv. Responsable
Participación del receptor trkA y su ligando, el factor de crecimiento nervioso (NGF), en la génesis y progresión del cáncer ovárico epitelial FONDECYT (1071036) Proyecto 2007-2010 Coinvestigador(a)
Participación del factor de crecimiento neuronal (NGF) y el receptor de baja afinidad p75NTR en el desarrollo folicular ovárico al término del período reproductivo FONDECYT (1061143) Proyecto 2006-2008 Inv. Responsable
Cambios en la actividad nerviosa simpática durante el desarrollo neonatal predispone el ovario poliquístico en la vida adulta FONDECYT (1050765) Proyecto 2005-2008 Coinvestigador(a)


Long-Term Effects of Early-Life Exposure to Environmental Oestrogens on Ovarian Function: Role of Epigenetics Cruz, G.; Foster, W; Paredes A.; Yi, KD; Uzumcu, M Review ISI SCOPUS JOURNAL OF NEUROENDOCRINOLOGY (2014)
Hormonal Programming Across the Lifespan Nugent B.M.; Tobet S.A.; Lara H.E.; Lucion A.B.; Wilson M.E.; Recabarren S.E.; Paredes A.H. Review ISI SCOPUS Hormone and Metabolic Research (2012)